JP6370785B2 - 前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法 - Google Patents

前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法 Download PDF

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JP6370785B2
JP6370785B2 JP2015527444A JP2015527444A JP6370785B2 JP 6370785 B2 JP6370785 B2 JP 6370785B2 JP 2015527444 A JP2015527444 A JP 2015527444A JP 2015527444 A JP2015527444 A JP 2015527444A JP 6370785 B2 JP6370785 B2 JP 6370785B2
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agent
specific antigen
imaging
prostate
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JP2015532641A (ja
JP2015532641A5 (enExample
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グオジエ ホー,
グオジエ ホー,
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ビセン メディカル, インコーポレイテッド
ビセン メディカル, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056Peptides, proteins, polyamino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2015527444A 2012-08-15 2013-03-15 前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法 Active JP6370785B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261683305P 2012-08-15 2012-08-15
US61/683,305 2012-08-15
PCT/US2013/032200 WO2014028057A1 (en) 2012-08-15 2013-03-15 Prostate specific antigen agents and methods of using same for prostate cancer imaging

Publications (3)

Publication Number Publication Date
JP2015532641A JP2015532641A (ja) 2015-11-12
JP2015532641A5 JP2015532641A5 (enExample) 2016-05-12
JP6370785B2 true JP6370785B2 (ja) 2018-08-08

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JP2015527444A Active JP6370785B2 (ja) 2012-08-15 2013-03-15 前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法

Country Status (7)

Country Link
US (1) US9371362B2 (enExample)
EP (1) EP2885006B1 (enExample)
JP (1) JP6370785B2 (enExample)
CN (1) CN104955484B (enExample)
AU (1) AU2013303233C1 (enExample)
CA (1) CA2882019C (enExample)
WO (1) WO2014028057A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5106397B2 (ja) 2005-09-02 2012-12-26 ビセン メディカル, インコーポレイテッド 生体適合性n,n−二置換スルホンアミド含有蛍光色素標識
EP1973575B1 (en) 2005-12-22 2019-07-24 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
AU2009205950C1 (en) 2008-01-18 2015-08-06 Visen Medical, Inc. Fluorescent imaging agents
AU2012253502C1 (en) 2011-05-09 2017-12-14 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
WO2013148319A1 (en) 2012-03-30 2013-10-03 Visen Medical, Inc. Bacterial imaging agents and methods of using same
AU2013303233C1 (en) 2012-08-15 2018-08-23 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
AU2014228504C1 (en) 2013-03-15 2019-10-03 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
CA2901000C (en) 2013-03-15 2023-03-14 Visen Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
US9713649B2 (en) 2014-01-24 2017-07-25 The Cleveland Clinic Foundation PSMA-targeting imaging agents
EP3827846B1 (en) 2015-08-18 2024-10-02 Rakuten Medical, Inc. Compositions, combinations and related methods for photoimmunotherapy
CN114699525A (zh) 2015-08-18 2022-07-05 乐天医药生技股份有限公司 酞菁染料偶联物的制造方法及稳定偶联物
KR102764076B1 (ko) * 2017-10-23 2025-02-05 더 존스 홉킨스 유니버시티 섬유아세포 활성 단백질-α(FAP-α)를 표적하는 영상화 및 방사선치료제
WO2024181456A1 (ja) * 2023-02-27 2024-09-06 富士フイルム株式会社 化合物及びこれを用いた標識生体物質
WO2024181454A1 (ja) * 2023-02-27 2024-09-06 富士フイルム株式会社 化合物及びこれを用いた標識生体物質
JPWO2024181455A1 (enExample) * 2023-02-27 2024-09-06

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5627027A (en) 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5569587A (en) 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US4981977A (en) 1989-06-09 1991-01-01 Carnegie-Mellon University Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups
JPH08501097A (ja) 1992-09-04 1996-02-06 ザ ゼネラル ホスピタル コーポレーション 臨床診断及び治療用部分を含む生体適合性ポリマー
US5808044A (en) 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
US5866679A (en) 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US6127134A (en) 1995-04-20 2000-10-03 Carnegie Mellon University Difference gel electrophoresis using matched multiple dyes
US6008373A (en) 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
IT1276833B1 (it) 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
US6004536A (en) 1995-11-14 1999-12-21 Molecular Probes, Inc. Lipophilic cyanine dyes with enchanced aqueous solubilty
WO1997040104A1 (en) 1996-04-19 1997-10-30 Amersham Pharmacia Biotech Uk Limited Squarate dyes and their use in fluorescent sequencing method
US6177404B1 (en) 1996-10-15 2001-01-23 Merck & Co., Inc. Conjugates useful in the treatment of benign prostatic hyperplasia
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US5877310A (en) 1997-04-25 1999-03-02 Carnegie Mellon University Glycoconjugated fluorescent labeling reagents
US6127333A (en) 1997-07-10 2000-10-03 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
ZA9810974B (en) 1997-12-02 1999-06-03 Merck & Co Inc Conjugates useful in the treatment of prostate cancer
ID24735A (id) * 1997-12-02 2000-08-03 Merck & Co Ltd Konjugat-konjugat yang berguna pada pengobatan kanker prostat
US6133445A (en) 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
WO1999051702A1 (en) 1998-04-08 1999-10-14 Terpetschnig Ewald A Luminescent compounds
US6002003A (en) 1998-04-14 1999-12-14 Beckman Instruments, Inc. Cyanine dye activating group with improved coupling selectivity
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6083486A (en) 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6174858B1 (en) * 1998-11-17 2001-01-16 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
DE69941067D1 (de) 1999-07-02 2009-08-13 Visen Medical Inc Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied
WO2001021624A1 (en) 1999-09-20 2001-03-29 Fuji Photo Film Co., Ltd. Compounds for fluorescence labeling
EP1341557A2 (en) 2000-10-27 2003-09-10 Beth Israel Deaconess Medical Center Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
EP1209205A1 (en) 2000-11-28 2002-05-29 Innosense S.r.l. Improved process and method for the preparation of asymetric monofunctionalised indocyanine labelling reagents and obtained compounds
EP1221465A1 (en) 2001-01-03 2002-07-10 Innosense S.r.l. Symmetric, monofunctionalised polymethine dyes labelling reagents
US20030044353A1 (en) 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
WO2003057175A2 (en) 2002-01-02 2003-07-17 Visen Medical, Inc. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
WO2003061711A2 (en) 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
EP1485716A1 (en) 2002-03-11 2004-12-15 Visen Medical, Inc. Optical imaging probes
EP1514093B1 (en) 2002-06-04 2021-04-28 Visen Medical, Inc. Imaging volumes with arbitrary geometries in non-contact tomography
US20060239916A1 (en) 2005-01-07 2006-10-26 Kai Licha Use of cyanine dyes for the diagnosis of proliferative diseases
TW200624440A (en) * 2005-01-07 2006-07-16 Univ Kaohsiung Medical Prostate-specific antigen (psa) probes for optical imaging
US8173819B2 (en) 2005-09-02 2012-05-08 Visen Medical, Inc. Nicotinic and picolinic acid derived near-infrared fluorophores
US7947256B2 (en) 2005-09-02 2011-05-24 Visen Medical, Inc. Biocompatible fluorescent imaging agents
JP5106397B2 (ja) 2005-09-02 2012-12-26 ビセン メディカル, インコーポレイテッド 生体適合性n,n−二置換スルホンアミド含有蛍光色素標識
EP1973575B1 (en) 2005-12-22 2019-07-24 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
WO2007109364A2 (en) 2006-03-20 2007-09-27 The General Hospital Corporation Intramolecularly quenched fluorochrome conjugates and methods of use
ES2670852T3 (es) 2007-02-09 2018-06-01 Visen Medical, Inc. Colorantes con policiclo y uso de los mismos
WO2008109832A2 (en) 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
AU2009205950C1 (en) * 2008-01-18 2015-08-06 Visen Medical, Inc. Fluorescent imaging agents
WO2009114776A2 (en) 2008-03-14 2009-09-17 Visen Medical, Inc. Integrin targeting agents and methods of using same
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
WO2011146143A2 (en) * 2010-05-21 2011-11-24 Ohmx Corporation Detection of cancer by assaying psa enzymatic activity
AU2012253502C1 (en) 2011-05-09 2017-12-14 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
AU2013303233C1 (en) 2012-08-15 2018-08-23 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging

Also Published As

Publication number Publication date
AU2013303233C1 (en) 2018-08-23
JP2015532641A (ja) 2015-11-12
US20140050662A1 (en) 2014-02-20
CN104955484A (zh) 2015-09-30
AU2013303233A1 (en) 2015-03-05
AU2013303233B2 (en) 2018-05-17
US9371362B2 (en) 2016-06-21
EP2885006A1 (en) 2015-06-24
CN104955484B (zh) 2019-01-15
WO2014028057A1 (en) 2014-02-20
EP2885006B1 (en) 2018-08-08
CA2882019C (en) 2021-02-09
CA2882019A1 (en) 2014-02-20

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