JP6359198B1 - がん細胞の代謝の特異性に基づく新規抗悪性腫瘍剤 - Google Patents
がん細胞の代謝の特異性に基づく新規抗悪性腫瘍剤 Download PDFInfo
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Abstract
Description
また、本発明は、がんの治療又は寛解のための尿のアルカリ化剤とビタミンCとメトホルミンの組み合せの使用に関する。
[1] がんの治療又は寛解に使用するための、尿のアルカリ化剤とビタミンCとを含む組み合わせ医薬。
[2] 尿のアルカリ化剤が、炭酸水素ナトリウム、炭酸ナトリウム、炭酸カルシウム、クエン酸ナトリウム、クエン酸カリウム、酢酸ナトリウム、乳酸ナトリウム、乳酸カリウム、酸化マグネシウム、水酸化マグネシウム、水酸化アルミニウム、ケイ酸アルミニウムからなる群から選択される一又は二以上を含む、[1]の医薬。
[3] 炭酸水素ナトリウムが3〜15g/日の用量にて経口投与される、[2]の医薬。
[4] ビタミンCが25〜50g/日の用量にて非経口投与される、[1]〜[3]のいずれかの医薬。
[5] さらに、メトホルミンを含む[1]〜[4]のいずれかの医薬。
[6] メトホルミンが250mg〜500mg/日の用量にて経口投与される、[5]の医薬。
[7] さらに、抗がん剤を含む[1]〜[6]のいずれかの医薬。
[8] がんが進行及び/又は末期のがんである、[1]〜[7]のいずれかの医薬。
[9] がんの治療又は寛解に使用するための、ビタミンCと併用投与される尿のアルカリ化剤を含む医薬組成物。
[10] がんの治療又は寛解に使用するための、尿のアルカリ化剤と併用投与されるビタミンCを含む医薬組成物。
[12] 尿のアルカリ化剤が、炭酸水素ナトリウム、炭酸ナトリウム、炭酸カルシウム、クエン酸ナトリウム、クエン酸カリウム、酢酸ナトリウム、乳酸ナトリウム、乳酸カリウム、酸化マグネシウム、水酸化マグネシウム、水酸化アルミニウム、ケイ酸アルミニウムからなる群から選択される一又は二以上を含む、[9]〜[11]のいずれかの医薬組成物。
[13] 炭酸水素ナトリウムが3〜15g/日の用量にて経口投与される、[12]の医薬組成物。
[14] ビタミンCが25〜50g/日の用量にて非経口投与される、[9]〜[13]のいずれかの医薬組成物。
[15] メトホルミンが250mg〜500mg/日の用量にて経口投与される、[11]の医薬組成物。
[16] 抗がん剤と併用投与される[9]〜[15]のいずれかの医薬組成物。
[17] がんが進行及び/又は末期のがんである、[9]〜[16]のいずれかの医薬組成物。
[18] がんの治療又は寛解の方法において、ビタミンCと共に、使用するための尿のアルカリ化剤。
[19] 尿のアルカリ化剤が、炭酸水素ナトリウム、炭酸ナトリウム、炭酸カルシウム、クエン酸ナトリウム、クエン酸カリウム、酢酸ナトリウム、乳酸ナトリウム、乳酸カリウム、酸化マグネシウム、水酸化マグネシウム、水酸化アルミニウム、ケイ酸アルミニウムからなる群から選択される一又は二以上を含む、[18]の尿のアルカリ化剤。
[20] 炭酸水素ナトリウムが3〜15g/日の用量にて経口投与される、[19]の尿のアルカリ化剤。
[22] 前記方法において、さらに抗がん剤と共に、使用するための[18]〜[21]のいずれかの尿のアルカリ化剤。
[23] がんが進行及び/又は末期のがんである、[18]〜[22]のいずれかの尿のアルカリ化剤。
[24] がんの治療又は寛解の方法において、尿のアルカリ化剤と共に、使用するためのビタミンC。
[25] 25〜50g/日の用量にて非経口投与される、[24]のビタミンC。
[26] 尿のアルカリ化剤が、炭酸水素ナトリウム、炭酸ナトリウム、炭酸カルシウム、クエン酸ナトリウム、クエン酸カリウム、酢酸ナトリウム、乳酸ナトリウム、乳酸カリウム、酸化マグネシウム、水酸化マグネシウム、水酸化アルミニウム、ケイ酸アルミニウムからなる群から選択される一又は二以上を含む、[24]又は[25]のビタミンC。
[27] 炭酸水素ナトリウムが3〜15g/日の用量にて経口投与される、[26]のビタミンC。
[28] 前記方法において、さらに抗がん剤と共に、使用するための[24]〜[27]のいずれかのビタミンC。
[29] がんが進行及び/又は末期のがんである、[24]〜[28]のいずれかのビタミンC。
[30] がんの治療又は寛解の方法において、尿のアルカリ化剤及びビタミンCと共に、使用するためのメトホルミン。
[32] ビタミンCが25〜50g/日の用量にて非経口投与される、[30]又は[31]のメトホルミン。
[33] 尿のアルカリ化剤が、炭酸水素ナトリウム、炭酸ナトリウム、炭酸カルシウム、クエン酸ナトリウム、クエン酸カリウム、酢酸ナトリウム、乳酸ナトリウム、乳酸カリウム、酸化マグネシウム、水酸化マグネシウム、水酸化アルミニウム、ケイ酸アルミニウムからなる群から選択される一又は二以上を含む、[30]〜[32]のいずれかのメトホルミン。
[34] 炭酸水素ナトリウムが3〜15g/日の用量にて経口投与される、[33]のメトホルミン。
[35] 前記方法において、さらに抗がん剤と共に、使用するための[30]〜[34]のいずれかのメトホルミン。
[36] がんが進行及び/又は末期のがんである、[30]〜[35]のいずれかのメトホルミン。
[37] がんの治療又は寛解のための方法であって、がん患者に尿のアルカリ化剤とビタミンCとを投与することを含む、方法。
[38] 尿のアルカリ化剤が、炭酸水素ナトリウム、炭酸ナトリウム、炭酸カルシウム、クエン酸ナトリウム、クエン酸カリウム、酢酸ナトリウム、乳酸ナトリウム、乳酸カリウム、酸化マグネシウム、水酸化マグネシウム、水酸化アルミニウム、ケイ酸アルミニウムからなる群から選択される一又は二以上を含む、[37]の方法。
[39] 炭酸水素ナトリウムが3〜15g/日の用量にて経口投与される、[38]の方法。
[40] ビタミンCが25〜50g/日の用量にて非経口投与される、[37]〜[39]のいずれかの方法。
[42] メトホルミンが250mg〜500mg/日の用量にて経口投与される、[41]の方法。
[43] さらに、抗がん剤を投与することを含む、[37]〜[42]のいずれかの方法。
[44] がんが進行及び/又は末期のがんである、[37]〜[43]のいずれかの方法。
[45] がん患者に尿のアルカリ化剤とビタミンCとを投与することを含むがんの治療又は寛解のための方法において使用するための医薬の製造における、尿のアルカリ化剤及び/又はビタミンCの使用。
[46] 前記方法において、さらにメトホルミンを投与することを含む、[45]の使用。
[47] がん患者に尿のアルカリ化剤とビタミンCとメトホルミンとを投与することを含むがんの治療又は寛解のための方法において使用するための医薬の製造における、メトホルミンの使用。
[48] 尿のアルカリ化剤が、炭酸水素ナトリウム、炭酸ナトリウム、炭酸カルシウム、クエン酸ナトリウム、クエン酸カリウム、酢酸ナトリウム、乳酸ナトリウム、乳酸カリウム、酸化マグネシウム、水酸化マグネシウム、水酸化アルミニウム、ケイ酸アルミニウムからなる群から選択される一又は二以上を含む、[45]〜[47]のいずれかの使用。
[49] 炭酸水素ナトリウムが3〜15g/日の用量にて経口投与される、[48]の使用。
[50] ビタミンCが25〜50g/日の用量にて非経口投与される、[45]〜[49]のいずれかの使用。
[52] 前記方法において、さらに抗がん剤を投与することを含む、[45]〜[51]のいずれかの使用。
[53] がんが進行及び/又は末期のがんである、[45]〜[52]のいずれかの使用。
切除不能進行膵臓がん(Stage IVb)の患者(男性、78歳)
再発した膵臓がん(膵体部がん)(Stage IVa)の患者(男性、67歳)
非小細胞肺がん(腺がん)(Stage IV)の患者(男性、80歳)
悪性胸膜中皮腫の患者(男性、67歳)
膵臓がん(膵体部がん)(Stage IVb)の患者(女性、66歳)
膵臓がん(膵体部がん)(Stage IVb)の患者(男性、54歳)
延命効果
Claims (11)
- 進行及び/又は末期の膵臓がん、非小細胞肺がん、又は胸膜中皮腫の治療又は寛解に使用するための、尿のアルカリ化剤とビタミンCとを含む組み合わせ医薬であって、尿のアルカリ化剤が尿をアルカリ化する3〜15g/日の用量にて毎日経口投与され、ビタミンCが25〜50g/日の用量にて非経口投与される、医薬。
- 尿のアルカリ化剤が、炭酸水素ナトリウム、炭酸ナトリウム、炭酸カルシウム、クエン酸ナトリウム、クエン酸カリウム、酢酸ナトリウム、乳酸ナトリウム、乳酸カリウム、酸化マグネシウム、水酸化マグネシウム、水酸化アルミニウム、ケイ酸アルミニウムからなる群から選択される一又は二以上を含む、請求項1に記載の医薬。
- さらに、メトホルミンを含む請求項1又は2に記載の医薬。
- メトホルミンが250mg〜500mg/日の用量にて経口投与される、請求項3に記載の医薬。
- さらに、抗がん剤を含む請求項1〜4のいずれか1項に記載の医薬。
- 進行及び/又は末期の膵臓がん、非小細胞肺がん、又は胸膜中皮腫の治療又は寛解に使用するための、25〜50g/日の用量にて非経口投与されるビタミンCと併用投与され、尿をアルカリ化する3〜15g/日の用量にて毎日経口投与される尿のアルカリ化剤を含む医薬組成物。
- 進行及び/又は末期の膵臓がん、非小細胞肺がん、又は胸膜中皮腫の治療又は寛解に使用するための、尿をアルカリ化する3〜15g/日の用量にて毎日経口投与される尿のアルカリ化剤と併用投与され、かつ25〜50g/日の用量にて非経口投与されるビタミンCを含む医薬組成物。
- 進行及び/又は末期の膵臓がん、非小細胞肺がん、又は胸膜中皮腫の治療又は寛解に使用するための、尿をアルカリ化する3〜15g/日の用量にて毎日経口投与される尿のアルカリ化剤及び25〜50g/日の用量にて非経口投与されるビタミンCと併用投与されるメトホルミンを含む医薬組成物。
- 尿のアルカリ化剤が、炭酸水素ナトリウム、炭酸ナトリウム、炭酸カルシウム、クエン酸ナトリウム、クエン酸カリウム、酢酸ナトリウム、乳酸ナトリウム、乳酸カリウム、酸化マグネシウム、水酸化マグネシウム、水酸化アルミニウム、ケイ酸アルミニウムからなる群から選択される一又は二以上を含む、請求項6〜8のいずれか1項に記載の医薬組成物。
- メトホルミンが250mg〜500mg/日の用量にて経口投与される、請求項8に記載の医薬組成物。
- 抗がん剤と併用投与される請求項6〜10のいずれか1項に記載の医薬組成物。
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WO2019142490A1 (ja) * | 2018-01-19 | 2019-07-25 | Delta-Fly Pharma株式会社 | がん患者の治療に有用な尿のアルカリ剤 |
US11246847B2 (en) | 2019-07-18 | 2022-02-15 | Delta-Fly Pharma, Inc. | Anticancer drug effect enhancer |
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JP6937065B1 (ja) * | 2021-03-10 | 2021-09-22 | 株式会社Wikom研究所 | 間質性肺炎の治療剤 |
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WO2019142490A1 (ja) * | 2018-01-19 | 2019-07-25 | Delta-Fly Pharma株式会社 | がん患者の治療に有用な尿のアルカリ剤 |
US11622976B2 (en) | 2018-01-19 | 2023-04-11 | Delta-Fly Pharma, Inc. | Urine alkali agent useful for treatment of cancer patient |
US11246847B2 (en) | 2019-07-18 | 2022-02-15 | Delta-Fly Pharma, Inc. | Anticancer drug effect enhancer |
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CN109641055A (zh) | 2019-04-16 |
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EP3456354A4 (en) | 2020-02-26 |
EP3456354A1 (en) | 2019-03-20 |
WO2019016928A1 (ja) | 2019-01-24 |
TW201907916A (zh) | 2019-03-01 |
US20200138855A1 (en) | 2020-05-07 |
TWI726133B (zh) | 2021-05-01 |
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