JP6333506B2 - Method for producing blood-derived component-containing substance, and blood-derived component-containing substance - Google Patents

Description

  The present invention relates to a substance containing a blood-derived component.

  Patent Document 1 describes that a constituent element of a human body is carbonized and then graphitized to produce an artificial diamond from the graphite. This artificial diamond is manufactured from the components of the human body. Therefore, the ornament using the artificial diamond can be a souvenir depending on the recipient.

International Publication No. 2004/105540

  As described in Patent Document 1, it is possible to produce artificial diamond from human body components. However, if an artificial diamond large enough to be a souvenir is to be manufactured, a large amount of the raw material is required. For example, when manufacturing artificial diamond based on blood, it is necessary to remove each component in blood and extract only carbon.

  Artificial diamond is produced only from carbon. Therefore, the person who receives the artificial diamond is manufactured from a substance derived from a specific person, or a substance derived from another (from an unrelated person, other animal, plant, etc.) It is difficult to determine whether it is produced from extracted carbon or the like. Therefore, the recipient of the artificial diamond can only get a sense of security by having the manufacturer guarantee that the diamond is an artificial diamond manufactured from a material derived from a specific person.

  In addition, in order to produce an artificial diamond large enough to be used as a decoration, a large amount of blood is required, and it is necessary to maintain it under a high pressure for a long time. As described above, there are various problems in producing a decorative article using a carbon component in blood.

  Then, an object of this invention is to manufacture easily the substance which can become a decoration using the component contained in the blood.

In order to solve the above-described problem, in one embodiment of the present invention, a step of extracting an inorganic component by reducing an organic component from a material containing blood, and a component different from the extracted inorganic component and the inorganic component are included. A step of mixing or bringing into contact with the mother substance, and heating in a state where the mother substance and the inorganic component are mixed or brought into contact with each other to introduce the inorganic component into the substance obtained from the mother substance A step of melting and crystallizing the base material and adding the inorganic component as an impurity to a crystal obtained from the base material , wherein the inorganic component is distributed as an impurity at least over the entire surface of the crystal. and optionally provides a process for the preparation of blood-derived component-containing substances, characterized in Rukoto.

  In another preferred embodiment, in the extracting step, the organic component may be reduced by baking the blood-containing material at 600 ° C. or higher.

  In another preferred embodiment, in the extracting step, the blood-containing material is fired so that the organic component is reduced to a weight of 0.4% or less with respect to the weight before firing. May be.

In another preferred embodiment, when the base material is melted and crystallized, it may be crystallized in a state where it does not come into contact with a solid other than the base material and the inorganic component. In another preferred embodiment, a crystal obtained from the parent material using the inorganic component as an impurity may be different in color from a crystal obtained when the inorganic component is not included.

  In another preferred embodiment, the crystal obtained from the parent material may be rutile, spinel or corundum.

  In another preferred embodiment, the blood may be cord blood.

In one embodiment of the present invention, a crystalline substance and an inorganic component contained in blood, introduced as an impurity into the crystalline substance, and at least as an impurity on the entire surface of the crystalline substance. The present invention provides a blood-derived component-containing substance characterized by containing a distributed inorganic component.

  In another preferred embodiment, the crystalline substance into which the inorganic component has been introduced may be transparent to light having at least a part of wavelengths included in visible light.

  In another preferred embodiment, the inorganic component may contain at least iron (Fe) and sodium (Na).

  According to the present invention, it is possible to easily produce a substance that can be used as a decorative product using components contained in blood.

It is a figure explaining the manufacturing method of the blood origin component containing substance in the embodiment of this invention, and the manufacturing method of a decorative article. It is a figure which shows the relationship between the baking temperature of the blood in embodiment of this invention, and the volume of the residue after baking. It is a photograph of the blood origin component containing rutile manufactured by the method of Example 1 of this invention. It is a figure which shows the fluorescence X-ray spectrum of the blood origin component containing rutile manufactured by the method of Example 1 of this invention. It is the photograph according to preparation conditions of the blood origin component containing rutile manufactured by the method of Example 1 of this invention. It is a figure which shows the fluorescence X-ray spectrum according to preparation conditions of the blood origin component containing rutile manufactured by the method of Example 1 of this invention. It is a figure which shows the spectrum of the iron by the LA-ICP-MS analysis according to preparation conditions of the blood origin component containing rutile manufactured by the method of Example 1 of this invention.

  The present inventors have found that a substance that can be used as a decorative article can be easily manufactured using an inorganic component contained in blood in view of the problems that occur in conventional artificial diamond using blood components.

<Embodiment>
The blood-derived component-containing substance in the embodiment of the present invention is a crystalline substance into which an inorganic component (inorganic component extracted from blood) derived from human or animal blood is introduced as an impurity. In this example, the crystalline substance is corundum, spinel, rutile, diamond, garnet, crystal, emerald, aquamarine, topaz, tourmaline, zirconia, etc. It is desirable that there is a crystal that is transparent (hereinafter referred to as “light transmitting”) with respect to light having at least a part of the wavelengths. Note that the crystalline inorganic material is not limited to jewelry, and may not have light transmittance. Moreover, crystalline is not only a single crystal but also a concept including polycrystal. In the following description, a substance that is a raw material for a crystalline substance is referred to as a parent substance.

  FIG. 1 is a diagram for explaining a method for producing a blood-derived component-containing substance and a method for producing a decorative article in an embodiment of the present invention. First, a material containing blood (hereinafter referred to as blood-containing material) is acquired (step S101). Blood corresponds to a blood-containing material. The blood may be umbilical cord blood. When the blood is umbilical cord blood, for example, placenta, umbilical cord and the like correspond to the blood-containing material. Note that blood may be in a liquid state or may be in a dry state. Therefore, even dry blood, umbilical cord, and the like fall under the blood-containing material.

  Subsequently, inorganic components contained in blood are extracted from the blood-containing material (step S111). In this example, the blood-containing material is fired. By this decomposition, the organic component contained in the blood-containing material is decomposed and the ratio of the organic component to the inorganic component is reduced, thereby extracting the inorganic component contained in the blood.

  FIG. 2 is a diagram showing the relationship between the baking temperature of blood and the volume of the residue after baking in the embodiment of the present invention. In this example, it is assumed that the blood-containing material is blood. In addition, the firing is performed in an air atmosphere. The residue is obtained as a result of baking blood. In this figure, the volume “100%” indicates the volume of blood (residue) after baking at 400 ° C., not the volume of blood before baking. Although blood contains a large amount of water, the blood baked at 400 ° C. has already almost evaporated. Therefore, the blood baked at 400 ° C. is greatly reduced from the blood volume before baking.

  As shown in FIG. 2, the blood baked at 600 ° C. or higher has a significantly reduced volume than the blood baked at 400 ° C. This indicates that organic components contained in blood are decomposed and evaporated by baking at 600 ° C. or higher. Therefore, in step S111, baking is preferably performed at 600 ° C. or higher. Since it is possible to further reduce the organic component, it is more desirable to bake at 900 ° C. or higher.

  In the example shown in FIG. 2, the case where blood is baked in an air atmosphere has been described. However, when the atmosphere during baking changes (for example, oxygen concentration, pressure, etc.), the temperature at which the organic component starts to change also changes. As described above, the appropriate baking temperature may vary depending on the baking conditions. In any case, the baking temperature is such that the weight of blood after baking is 0.4% or less of the blood before baking. It is desirable that the firing atmosphere is determined. More desirably, the firing temperature and firing atmosphere are determined so as to be 0.25% or less. If the organic component is reduced to this extent, crystallization in step S113 described later is facilitated.

  Returning to FIG. 1, the description will be continued. Subsequent to step S111, the inorganic component extracted from blood is mixed with the mother substance (step S112). In the following description, “inorganic component” refers to a residue obtained by firing in step S111. Therefore, when the organic component is not completely removed from the blood, the organic component may remain in the inorganic component (residue).

  The inorganic component extracted from the blood is a powdery substance, and when mixed with the powdery mother substance, they are in contact with each other and can react. In addition, since it is sufficient that the inorganic component and the base material can be made to react with each other, it is not limited to the case of mixing, and it may be simply placed on the base material and brought into contact. Further, the base material may not be in the form of powder, and may be in the form of a lump such as a crystallized state or a compression-molded state. Also in this case, the base material and the inorganic component may be brought into contact with each other by placing the inorganic component on the base material.

  The amount of the inorganic component relative to the base material can be variously set according to the content of the process in step S113, and the settable range may differ depending on the base material. For example, when the crystallization in step S113 is performed by the floating zone (FZ) method, the amount of the inorganic component relative to the parent material is determined as follows.

  For example, when the crystal obtained from the base material is rutile, the inorganic component is desirably 0.0001 g or more and 0.05 g or less with respect to 1 g of the rutile base material. More preferably, it is 006 g or less. Further, when the crystal obtained from the base material is spinel, the inorganic component is desirably 0.001 g or more and 0.1 g or less with respect to 1 g of the spinel base material. It is further desirable that it is not more than 02 g.

  Subsequently, the base material and the inorganic component are heated in a mixed state, and the inorganic component is introduced into the crystalline material obtained from the base material (step S113). In this example, a crystallized substance (blood-derived component-containing substance) is obtained by heating at a temperature exceeding the melting point of the mother substance to melt the mother substance and then gradually cooling it. Thereby, an inorganic component is introduced into the crystallized substance. In this crystallization, various known methods such as a floating zone method, a Czochralski method, a Bernoulli method, a flux method, a hydrothermal synthesis method, and a stationary slow cooling method can be used. The blood-derived component-containing substance is manufactured through the processes up to step S113.

  Subsequently, the blood-derived component-containing substance is processed (step S121). In this process, the blood-derived component-containing substance is cut, polished, etc., and arranged to give a beautiful appearance. The shape after processing may be a polyhedron shape, may include a curved surface in part, or may be spherical. This process produces a decorative article such as a cut jewel. In addition to jewelry, such as earrings, necklaces, bracelets, watches, and glasses, and processed jewelry containing blood-derived component-containing substances are also attached to decorations such as table clocks, jewelry boxes, figurines, furniture, etc. Good.

  Of the inorganic components (inorganic components extracted from blood) as impurities contained in the blood-derived component-containing material thus obtained, iron (Fe) and sodium (Na) are used as the inorganic components of blood. Many are included. Therefore, it is desirable that at least iron (Fe) and sodium (Na) have concentrations that can be detected by nondestructive analysis. More desirably, it is also possible to detect magnesium (Mg) contained in blood in a relatively large amount.

  Nondestructive analysis includes, for example, XRF (fluorescence X-ray analysis), XPS (X-ray photoelectron spectroscopy), EDX (energy dispersive X-ray analysis), and the like. If non-destructive analysis can be performed, even when it is a decorative product, it can be confirmed that the blood-derived component is introduced into the blood-derived component-containing substance without deteriorating its value. In addition, if the concentration can be measured by a highly accurate method, the difference in the concentration ratio between iron and sodium by each person may be confirmed. For example, analysis by ICP-MS (inductively coupled plasma mass spectrometry) is also possible. In this case, although it is not strictly non-destructive, it is analyzed using a method in which the surface of the decorative article is evaporated to such an extent that it cannot be visually recognized (several microns to several tens of microns) by laser ablation (LA-ICP-MS (laser Ablation inductively coupled plasma mass spectrometry mass spectrometry)). Therefore, even if it is not non-destructive, it rarely loses its value as a decoration. Therefore, a person who receives this ornament as a souvenir can have an attachment to the souvenir.

<Example>
[Example 1]
As an example of the above-described method for producing a blood-derived component-containing substance, a case where a parent substance is crystallized using a floating zone method will be described. Here, the crystal is rutile (TiO ₂ ).

(1) Put blood in a heat-resistant container, and perform baking in an air atmosphere at 950 ° C. for 15 minutes. As a result, 0.002 g of a powdery residue (inorganic component) per 1 ml of blood was obtained. Even with about 5 ml of blood, a residue sufficient to obtain several carat crystals can be obtained.
(2) Titanium oxide (TiO ₂ ) powder, which is the base material of rutile, was mixed with the residue obtained in (1). When mixing, the amount of the residue was 0.004 g with respect to 1 g of the base material.
(3) In order to produce a raw material rod from the mixture produced in (2), this mixture was compression molded and fired at 1200 ° C.
(4) The raw material rod produced in (3) was crystallized by the floating zone method to obtain rutile containing a blood-derived component. At this time, the crystal growth atmosphere was O ₂ /0.45 mpa, and the crystal growth rate was 3 mm / h.

  FIG. 3 is a photograph of a blood-derived component-containing rutile produced by the method of Example 1 of the present invention. Fig.3 (a) is a photograph which shows the rutile obtained in said (4). FIG.3 (b) cuts the rutile of Fig.3 (a), and makes it the shape of a jewel. Moreover, FIG.3 (c) is an example at the time of mixing the quantity of the residue in said (2) as a ratio of 0.006g with respect to 1g of base materials.

  In FIGS. 3 (a) and 3 (b), it is a clear light yellow rutile. In FIG. 3 (c), the color is darker than that in FIG. 3 (b), resulting in reddish brown rutile. In the production condition (4) above, when no residue is used, rutile that is nearly colorless and transparent is obtained. When the amount of the residue in (2) is mixed at a rate of 0.002 g with respect to 1 g of the base material, a colored product is observed. On the other hand, when the amount of the residue is mixed at a ratio of 0.008 g with respect to 1 g of the base material, it becomes dark brown and light transmittance can be lowered. Thus, rutile can be colored by using a residue containing a lot of inorganic components contained in blood.

FIG. 4 is a diagram showing a fluorescent X-ray spectrum of blood-containing component-containing rutile produced by the method of Example 1 of the present invention. FIG. 4 shows the result of analyzing rutile when the amount of the residue in (2) is mixed at a ratio of 0.008 g with respect to 1 g of the base material by fluorescent X-ray (JEOL Ltd. Fluorescent X (Measured with JSX-3201M line analyzer). From this spectrum, iron (Fe) and sodium (Na) are detected in addition to titanium contained in titanium oxide (TiO ₂ ) as a base material, and magnesium (Mg) is also detected. Even when the amount of the residue is mixed at a ratio of 0.002 g with respect to 1 g of the base material, iron and sodium can be detected by using an analysis method with high detection accuracy.

[Example 2]
In Example 1, the crystallized crystal was rutile, but in Example 2, a case where spinel (MgAl ₂ O ₄ ) is used will be described.

(1) Put blood in a heat-resistant container, and perform baking in an air atmosphere at 950 ° C. for 15 minutes. As a result, 0.002 g of a powdery residue (inorganic component) per 1 ml of blood was obtained. Even with about 5 ml of blood, a residue sufficient to obtain several carat crystals can be obtained.
(2) Magnesium oxide (MgO) and aluminum oxide (Al ₂ O ₃ ) powders, which are spinel mother materials, were mixed with the residue obtained in (1). When mixing, the amount of the residue was 0.02 g with respect to 1 g of the base material.
(3) In order to produce a raw material rod from the mixture produced in (2), this mixture was compression molded and fired at 1400 ° C.
(4) The raw material rod produced in (3) was crystallized by the floating zone method to obtain a spinel containing blood-derived components. At this time, the crystal growth atmosphere was O ₂ /0.45 mpa, and the crystal growth rate was 5 mm / h.

  When produced in this way, a light gray spinel is obtained. In the production condition (4) above, spinel that is almost colorless and transparent is obtained when no residue is used. Thus, spinel can be colored by using a residue containing a lot of inorganic components contained in blood.

[Example 3]
In Example 1, the crystallized crystal was rutile, and in Example 2, it was spinel. In Example 3, the case of corundum (Al ₂ O ₃ ) will be described.

(1) Put blood in a heat-resistant container, and perform baking in an air atmosphere at 950 ° C. for 15 minutes. As a result, 0.002 g of a powdery residue (inorganic component) per 1 ml of blood was obtained. Even with about 5 ml of blood, a residue sufficient to obtain several carat crystals can be obtained.
(2) A powder of aluminum oxide (Al ₂ O ₃ ) serving as a corundum base material and the residue obtained in (1) were mixed. When mixing, the amount of the residue was set to a ratio of 0.1 g to 1 g of the base material.
(3) In order to produce a raw material rod from the mixture produced in (2), this mixture was compression molded and fired at 1500 ° C.
(4) The raw material rod produced in (3) was crystallized by the floating zone method to obtain corundum containing blood-derived components. I wrote corundum here, but corundum is a term used to describe the crystal structure. From the point of view of jewelry, corundum can be rephrased as ruby for red coloring and sapphire for other coloring or colorless. It is noted. At this time, the crystal growth atmosphere was O ₂ /0.45 mpa, and the crystal growth rate was 5 mm / h.

  When produced in this way, a light gray corundum is obtained. In the production condition (4) above, when no residue is used, corundum that is almost colorless and transparent is obtained. Thus, corundum can be colored by using a residue containing a lot of inorganic components contained in blood.

[Analysis result comparison]
In the step (2) of Example 1 described above, when the residue is not mixed with the base material (hereinafter referred to as condition (a)), the amount of the residue is 0.004 g with respect to 1 g of the base material ( Hereinafter, the condition (b)), and the amount of the residue is 0.006 g with respect to 1 g of the base material (hereinafter referred to as the condition (c)) will be described for comparison of the results of two types of analysis. To do. The two types of analysis are the XRF analysis (measured by JEOL Ltd. XRF fluorescence analyzer JSX-3201M) and LA-ICP-MS analysis (measured by Agilent ICP mass spectrometer 7500A). . And as an analysis object element, it shall be iron contained in a lot of residue components.

  FIG. 5 is photographs according to production conditions of blood-derived component-containing rutile produced by the method of Example 1 of the present invention. FIG. 5 (a) shows a condition (a), FIG. 5 (b) shows a condition (b), and FIG. 5 (c) shows a decorative article using rutile produced under the condition (c). As shown in FIG. 5, the manufactured decorative article is almost colorless and transparent under the condition (a), yellow under the condition (b), and darker yellow under the condition (c).

  FIG. 6 is a diagram showing fluorescent X-ray spectra according to production conditions of blood-derived component-containing rutile produced by the method of Example 1 of the present invention. 6 (a) shows the condition (a), FIG. 6 (b) shows the condition (b), and FIG. 6 (c) shows the X-ray fluorescence of the rutile (decorative product shown in FIG. 5) prepared under the condition (c). The spectrum (horizontal axis: energy, vertical axis: intensity) obtained by analysis is shown. Under conditions (a) and (b), the peak of iron (Fe) is hidden behind the background level. On the other hand, in the condition (c), an iron (Fe) peak (particularly a 6.4 keV Kα line) is clearly observed. Thus, in the fluorescent X-ray analysis, it is considered that there is a detection lower limit between the condition (b) and the condition (c). However, since the lower limit of detection differs depending on the analysis environment (such as the measurement accuracy of the apparatus), it may be possible to detect iron even in condition (b) and even when a residual component is contained in a smaller proportion.

  FIG. 7 is a diagram showing iron spectra by LA-ICP-MS analysis according to production conditions of blood-derived component-containing rutile produced by the method of Example 1 of the present invention. FIG. 7 (a) shows the condition (a), FIG. 7 (b) shows the condition (b), and FIG. 7 (c) shows the rutile (decorative product shown in FIG. 5) prepared under the condition (c) by ICP analysis. The spectrum of the obtained iron (Fe) (horizontal axis: time, vertical axis: intensity) is shown. In condition (a), iron is not detected, but in conditions (b) and (c), iron is detected.

  In this way, iron contained in a large amount of residual components can be detected by non-destructive analysis or almost non-destructive analysis (destructive analysis not visible). Therefore, it is possible to directly prove to the client who manufactures the decorative product that the blood-derived component is contained in the decorative product itself by performing analysis after processing the blood-derived component-containing substance as the decorative product. it can. Furthermore, the non-destructive or almost non-destructive analysis allows the ornament to be delivered to the client without losing its value as an ornament.

<Modification>
As mentioned above, although embodiment of this invention and its Example were demonstrated, this invention can be implemented in various aspects as follows.

[Modification 1]
In the above-described embodiment, the substance obtained from the parent material is a crystalline inorganic substance, but may be an amorphous inorganic substance such as glass. In this case, in the process of step S113, the base material is not crystallized by heating it to its melting point or higher and gradually cooling it, but it is heated to a temperature higher than the glass transition point to lower the temperature. Get the substance. For example, silicon dioxide (SiO ₂ ) may be used as the amorphous substance.

[Modification 2]
In the above-described step S113, when the base material is crystallized, the color state of crystals obtained from the base material can be controlled by controlling the gas atmosphere during heating and cooling. In addition, the coloring state can be controlled by adding a substance composed of another element to the base material. For example, when the crystal is corundum, aluminum oxide (Al ₂ O ₃ ) serves as a base material, but if further added with chromium oxide (Cr ₂ O ₃ ) is used as a base material, the inorganic component to be introduced Regardless, it can be colored red.

  According to Examples 1 and 2 described above, the crystals in which the inorganic component is introduced are colored, that is, the optical characteristics are different from the crystals in which the inorganic component is not introduced. Therefore, it was recognized that the inorganic component was introduced into the crystal, but when it was colored with another additive as in this modification, it was not possible to recognize whether or not the inorganic component was introduced by coloring. On the other hand, as shown in FIG. 4, FIG. 6, and FIG. Therefore, in the spectrum obtained from the result of analysis such as X-ray fluorescence analysis, the additive element should be set so that the peak obtained by the additive for coloring does not overlap the peak obtained by the presence of iron and sodium. It is desirable to decide.

[Modification 3]
In the process of step S111 described above, the inorganic component was extracted by baking the material containing blood to reduce the amount of the organic component, but the inorganic component was extracted by chemical treatment such as using chemicals. Also good.

Claims (9)

Extracting inorganic components by reducing organic components from blood-containing materials; and
Mixing or contacting the extracted inorganic component and a base material having a component different from the inorganic component;
The step of introducing the inorganic component into a substance obtained from the parent material by mixing or heating the mother material and the inorganic component in contact with each other, and melting and crystallizing the parent material A step of containing the inorganic component as an impurity in a crystal obtained from the parent material,
The inorganic component is distributed as an impurity at least over the entire surface of the crystal ;
The method for producing a blood-derived component-containing substance, wherein the crystal into which the inorganic component is introduced has transparency to light having at least a part of wavelengths included in visible light .   2. The method for producing a blood-derived component-containing substance according to claim 1, wherein in the extracting step, the organic component is decreased by baking the material containing blood at 600 ° C. or higher.   The material containing blood is baked in the extracting step so that the weight of the organic component is reduced to 0.4% or less with respect to the weight before baking. A method for producing a blood-derived component-containing substance according to claim 1 or 2.   The blood according to any one of claims 1 to 3, wherein when the mother substance is melted and crystallized, it is crystallized in a state where it does not come into contact with a solid other than the mother substance and the inorganic component. A method for producing a derived component-containing substance.   The method for producing a blood-derived component-containing substance according to any one of claims 1 to 4, wherein the crystal obtained from the matrix is rutile, spinel or corundum.   6. The method for producing a blood-derived component-containing substance according to any one of claims 1 to 5, wherein the blood is umbilical cord blood.   The blood-derived crystal according to any one of claims 1 to 6, wherein a crystal obtained from the parent material with the inorganic component as an impurity is different in color from a crystal obtained when the inorganic component is not included. A method for producing an ingredient-containing material. A crystalline substance,
An inorganic component contained in blood, see contains an inorganic component wherein is introduced as an impurity into the crystalline materials are distributed as an impurity in the entire surface of at least the crystalline material,
The blood-derived component-containing substance, wherein the crystalline substance into which the inorganic component has been introduced is transmissive to light having at least a part of wavelengths included in visible light . The blood-derived component-containing substance according to claim 8 , wherein the inorganic component contains at least iron (Fe) and sodium (Na).