JP6332622B2 - Antibacterial / preservative and composition for external use - Google Patents
Antibacterial / preservative and composition for external use Download PDFInfo
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- JP6332622B2 JP6332622B2 JP2014114379A JP2014114379A JP6332622B2 JP 6332622 B2 JP6332622 B2 JP 6332622B2 JP 2014114379 A JP2014114379 A JP 2014114379A JP 2014114379 A JP2014114379 A JP 2014114379A JP 6332622 B2 JP6332622 B2 JP 6332622B2
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本発明は、ヒバ油と銅化合物との混合物を含有する抗菌・防腐剤および外用組成物に関する。 The present invention relates to an antibacterial / preservative containing a mixture of hiba oil and a copper compound and a composition for external use.
従来より、ヒノキチオールは医薬や化粧品の防腐剤として用いられている。また、ヒノキチオールと銅化合物との混合物、反応物についても同様に防腐剤として用いられることが知られている。たとえば、特許文献1、2には、銅化合物とヒノキチオールとを含有する組成物の抗微生物効果、殺菌効果が開示されている。 Conventionally, hinokitiol has been used as a preservative for pharmaceuticals and cosmetics. Further, it is known that a mixture of hinokitiol and a copper compound and a reaction product are similarly used as a preservative. For example, Patent Documents 1 and 2 disclose the antimicrobial effect and bactericidal effect of a composition containing a copper compound and hinokitiol.
しかしながら、特許文献1、2に記載のヒノキチオール/銅化合物では、抗菌・防腐力が十分でなく、より少量で即効性を有する抗菌・防腐剤が望まれている。 However, the hinokitiol / copper compounds described in Patent Documents 1 and 2 have insufficient antibacterial / preservative power, and an antibacterial / preservative having immediate effect in a smaller amount is desired.
本発明は、上記問題点に鑑みなされたものであり、ヒバ油と銅化合物とを含有する抗菌・防腐剤およびそれを用いた外用組成物を提供することを目的とする。 This invention is made | formed in view of the said problem, and it aims at providing the antibacterial and antiseptic | preservative containing a Hiba oil and a copper compound, and the external composition using the same.
本発明者らは、ヒバ油と、銅化合物との混合させることにより、抗菌・防腐性が向上し、低濃度で効果があることを見出し、本発明を完成するに至った。
すなわち、本発明の抗菌・防腐剤は、ヒバ油および銅化合物を含むことを特徴としている。The present inventors have found that antibacterial and antiseptic properties are improved by mixing Hiba oil and a copper compound and are effective at a low concentration, and the present invention has been completed.
That is, the antibacterial / preservative of the present invention is characterized by containing hiba oil and a copper compound.
本発明の抗菌・防腐剤は、低濃度で且つ即効性に優れるため、この抗菌・防腐剤を含有する組成物において優れた抗菌・防腐効果を有する。 Since the antibacterial / preservative of the present invention is low in concentration and excellent in immediate effect, the composition containing this antibacterial / preservative has an excellent antibacterial / preservative effect.
以下、本発明の実施形態について説明する。 Hereinafter, embodiments of the present invention will be described.
本発明の抗菌・防腐剤は、ヒバ油と銅化合物との混合物を含有することを特徴としている。
上記ヒバ油と銅化合物との混合物は、驚くべきことに、低濃度においても良好な抗菌・防腐性を有し、特にカンジダ アルビカンスに対して低濃度においても特異的に抗菌・防腐性を有する。The antibacterial / preservative of the present invention is characterized by containing a mixture of hiba oil and a copper compound.
Surprisingly, the mixture of Hiba oil and copper compound has good antibacterial and antiseptic properties even at low concentrations, and specifically has antibacterial and antiseptic properties even at low concentrations against Candida albicans.
本発明で用いられるヒバ油は、タイワンヒノキや青森ヒバから抽出された精油であり、ヒノキチオールと、それ以外の天然成分を含む混合物である。 The hiba oil used in the present invention is an essential oil extracted from Taiwan Hinoki and Aomori hiba, and is a mixture containing Hinokithiol and other natural ingredients.
上記銅化合物としては、特に限定がなく従来公知のものを広く使用できるが、例えば塩化銅(I)、酢酸銅(II)、塩化アンモニウム銅(II)、臭化銅(I)、臭化銅(II)、臭化銅(I)−硫化ジメチル錯体、炭酸銅(II)、クエン酸銅(II)、シアン化銅(I)、4−シクロヘキシル酪酸銅、塩化二アンモニウム銅(II)、二燐酸銅(II)、弗化銅(II)、蟻酸銅(II)、グルコン酸銅(II)、水酸化銅(II)、沃化銅(I)、ナフテン酸銅、硝酸銅(II)、オレイン酸銅(II)、蓚酸銅(II)、酸化銅(II)、燐酸銅(II)、フタル酸銅(II)、塩化カリウム銅(II)、ロダン化銅(I)、硫酸銅(II)、硫化銅(II)、チオシアン酸銅(I)、ウスニン酸銅(II)、アデノシン三リン酸銅、アセチルメチオニン銅、アスパラギン酸銅、銅クロロフィル、銅クロロフィリンナトリウム、ピロリドンカルボン酸銅、ヒノキチオール銅、ニコチン酸銅化合物、ニコチン酸アミド銅化合物、ピコリン酸銅化合物、ピコリン酸アミド銅化合物、青銅、孔雀石、孔雀石抽出物、ならびにアミノ酸、ペプチドから選ばれる化合物の銅塩、銅錯体および銅複合体等を挙げることができる。アミノ酸、ペプチドから選ばれる化合物の銅塩、銅錯体及び銅複合体としては、たとえば、アスパラギン酸、アセチルメチオニン銅、トリペプチド−1銅、酢酸ビス(トリペプチド−1)銅、塩基性炭酸銅、(銀/銅)ゼオライト、(銅クロロフィリンNa/亜硫酸水素Na)複合物、PCA銅メチルシラノール、アセチルチロシネートメチルシラノール銅、サッカロミセス/銅培養物、EDTA−2Na/銅等が挙げられる。本発明では、これら銅化合物を1種単独で使用してもよいし、2種以上混合して使用してもよい。上記銅化合物の中でも、孔雀石抽出物、グルコン酸銅が好ましいものとして挙げられる。 The copper compound is not particularly limited and conventionally known ones can be widely used. For example, copper chloride (I), copper acetate (II), ammonium copper (II) chloride, copper bromide (I), copper bromide. (II), copper bromide (I) -dimethyl sulfide complex, copper (II) carbonate, copper (II) citrate, copper (I) cyanide, copper 4-cyclohexylbutyrate, copper diammonium chloride (II), two Copper (II) phosphate, copper (II) fluoride, copper (II) formate, copper (II) gluconate, copper (II) hydroxide, copper (I) iodide, copper naphthenate, copper (II) nitrate, Copper (II) oleate, copper (II) oxalate, copper (II) oxide, copper (II) phosphate, copper (II) phthalate, copper (II) potassium chloride, copper (I) rhodanide, copper sulfate (II) ), Copper sulfide (II), copper thiocyanate (I), copper (II) usnate, adenosine triphosphate , Copper acetylmethionine, copper aspartate, copper chlorophyll, copper chlorophyllin sodium, copper pyrrolidone carboxylate, copper hinokitiol, copper nicotinate, copper nicotinate, copper picolinate, copper picolinate, bronze, peacock stone And peacock stone extract, and copper salts, copper complexes and copper complexes of compounds selected from amino acids and peptides. Examples of the copper salt, copper complex and copper complex of a compound selected from amino acids and peptides include aspartic acid, acetylmethionine copper, tripeptide-1 copper, bis (tripeptide-1) copper, basic copper carbonate, (Silver / copper) zeolite, (copper chlorophyllin Na / hydrogen sulfite Na) composite, PCA copper methylsilanol, acetyl tyrosinate methylsilanol copper, Saccharomyces / copper culture, EDTA-2Na / copper and the like. In this invention, these copper compounds may be used individually by 1 type, and 2 or more types may be mixed and used for them. Among the above copper compounds, peacock stone extract and copper gluconate are preferable.
上記ヒバ油と銅化合物との混合物においては、ヒバ油に含まれるヒノキチオールと銅とのモル比が1:0.8〜1:1.2であることが好ましい。この範囲では、ヒバ油に含まれるヒノキチオールと銅とが塩や錯体を形成しやすくなる。
外用組成物に上記ヒバ油と銅化合物との混合物を添加する場合には、防腐力を十分発揮させるために、ヒノキチオールの割合が、0.00001〜0.01重量%であることが好ましく、0.0001〜0.005重量%であることがより好ましい。In the mixture of the said Hiba oil and a copper compound, it is preferable that the molar ratio of hinokitiol and copper contained in Hiba oil is 1: 0.8 to 1: 1.2. Within this range, hinokitiol and copper contained in the hiba oil are likely to form a salt or complex.
In the case of adding a mixture of the above Hiba oil and copper compound to the composition for external use, the ratio of hinokitiol is preferably 0.00001 to 0.01% by weight in order to sufficiently exhibit the antiseptic power, More preferably, it is 0.0001 to 0.005% by weight.
上記ヒバ油と銅化合物との混合物を、水性組成物に配合する際には、界面活性剤で可溶化させて使用することが好ましい。上記界面活性剤としては、特に限定されるものではないが、例えば、陰イオン界面活性剤、非イオン界面活性剤、両性界面活性剤又は陽イオン界面活性剤を挙げることできる。中でも、非イオン界面活性剤が好ましく、可溶化の観点から特にショ糖脂肪酸エステルが好ましい。
上記ショ糖脂肪酸エステルにおける脂肪酸としては、炭素数8〜22の飽和、不飽和のいずれの脂肪酸でも良く、直鎖状、分岐状のいずれでも良く、また、これらの混合物でも良い。これらの脂肪酸としては、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、イソステアリン酸、オレイン酸などが挙げられる。
上記界面活性剤のHLBは、可溶化の観点から16以上であることが好ましい。また、エステル化度は特に限定されず、数種類のエステル化度の混合物でも良い。
本発明で使用される界面活性剤中でも特に好ましいものとしては、ショ糖ラウリン酸エステルが挙げられる。When the mixture of the above Hiba oil and the copper compound is blended in the aqueous composition, it is preferably used after being solubilized with a surfactant. Although it does not specifically limit as said surfactant, For example, anionic surfactant, a nonionic surfactant, an amphoteric surfactant, or a cationic surfactant can be mentioned. Among these, nonionic surfactants are preferable, and sucrose fatty acid esters are particularly preferable from the viewpoint of solubilization.
The fatty acid in the sucrose fatty acid ester may be a saturated or unsaturated fatty acid having 8 to 22 carbon atoms, may be linear or branched, or may be a mixture thereof. Examples of these fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, and oleic acid.
The HLB of the surfactant is preferably 16 or more from the viewpoint of solubilization. The degree of esterification is not particularly limited, and a mixture of several kinds of esterification degrees may be used.
Among the surfactants used in the present invention, sucrose laurate is particularly preferable.
本発明の防腐剤および外用組成物に使用される溶剤としては、水、エタノール、1,3−プロパンジオール、グリセリン、1,3−ブチレングリコール、プロピレングリコール、ジグリセリン、カルビトール、ヘキシレングリコール、PEG、イソプロパノール等が挙げられる。
また、本発明の外用組成物におけるpHは、3〜9が好ましい。このpHの調整は、従来公知の方法にて、塩酸、クエン酸等の酸や、水酸化ナトリウム、アルギニン等の塩基により調整すればよい。さらに、安定性の観点から、クエン酸緩衝液、リン酸緩衝液等の緩衝液にてpHを一定に保つことが好ましい。Examples of the solvent used in the preservative and the external composition of the present invention include water, ethanol, 1,3-propanediol, glycerin, 1,3-butylene glycol, propylene glycol, diglycerin, carbitol, hexylene glycol, Examples thereof include PEG and isopropanol.
Moreover, as for pH in the external composition of this invention, 3-9 are preferable. The pH may be adjusted by a conventionally known method using an acid such as hydrochloric acid or citric acid, or a base such as sodium hydroxide or arginine. Furthermore, from the viewpoint of stability, it is preferable to keep the pH constant with a buffer solution such as a citrate buffer solution or a phosphate buffer solution.
本発明の防腐剤は、通常外用剤や化粧料に用いられる原料、例えば香料、色素、界面活性剤、油分、保湿剤、アルコール類、増粘剤、酸化防止剤、金属イオン封鎖剤、着色防止剤、紫外線吸収・散乱剤、ビタミン類、アミノ酸類、栄養剤、抗炎症剤、血管拡張剤、ホルモン剤、収斂剤、抗ヒスタミン剤、皮脂抑制剤、角質剥離・溶解剤、抗脂漏剤、鎮痒剤などの薬剤を配合してもよい。これにより、化粧料や外用医薬として好適に使用できる。つまり、本発明の防腐剤は、他の化粧品や原料等に添加して使用される。
本発明の外用組成物は、そのままで、化粧料や外用医薬として使用できる。また、化粧料としては、化粧水、乳液、クリーム、ヘアトニック等に適用される。The preservative of the present invention is a raw material usually used for external preparations and cosmetics, such as fragrances, pigments, surfactants, oils, moisturizers, alcohols, thickeners, antioxidants, sequestering agents, anti-coloring agents. Agents, UV absorbers / scatterers, vitamins, amino acids, nutrients, anti-inflammatory agents, vasodilators, hormone agents, astringents, antihistamines, sebum suppressants, exfoliating / dissolving agents, antiseborrheic agents, antipruritic agents You may mix | blend medicines, such as. Thereby, it can be conveniently used as cosmetics or external medicine. That is, the preservative of the present invention is used by adding to other cosmetics and raw materials.
The external composition of the present invention can be used as it is as a cosmetic or external medicine. Moreover, as cosmetics, it is applied to lotion, milky lotion, cream, hair tonic and the like.
以下、実施例によって本発明を具体的に説明するが、これらは本発明の範囲を限定するものではない。 EXAMPLES Hereinafter, the present invention will be specifically described by way of examples, but these do not limit the scope of the present invention.
<抗菌・防腐剤の調製>
下記表1の組成に基づき、抗菌・防腐剤A〜Fを調製した。
Based on the composition shown in Table 1 below, antibacterial / preservatives A to F were prepared.
<実施例、比較例>
上記抗菌・防腐剤A〜Fを用い、下記表2の組成に基づき、実施例および比較例に係る組成物を得た。これらの実施例、比較例の組成物を検体として、ハロー試験を実施した。ハロー試験は、50μLの検体を浸み込ませて室温で乾燥させた8mmの円形のろ紙を、菌濃度を106個/mL〜107個/mLに調製した試験菌液と十分混釈し凝固させた寒天培地上に置き、35℃〜37℃で36時間培養後に、ハローを測定した。菌としては、黄色ブドウ球菌(SCD寒天培地)、カンジダ アルビカンス(GP寒天培地)のそれぞれで行った。
その結果を測定方法は表2に示す。<Examples and comparative examples>
Using the antibacterial / preservatives A to F, compositions according to Examples and Comparative Examples were obtained based on the compositions shown in Table 2 below. A halo test was conducted using the compositions of these Examples and Comparative Examples as specimens. In the halo test, an 8 mm circular filter paper soaked with 50 μL of sample and dried at room temperature was sufficiently mixed with the test bacterial solution prepared at a bacterial concentration of 10 6 cells / mL to 10 7 cells / mL. After placing on a coagulated agar medium and culturing at 35 ° C. to 37 ° C. for 36 hours, halo was measured. As the bacteria, S. aureus (SCD agar medium) and Candida albicans (GP agar medium) were used.
The measurement method is shown in Table 2.
驚くべきことに、ヒバ油と銅化合物との混合系においてのみ、上記低濃度にて、カンジダ アルビカンスに対してもハローが観察された。つまり、このヒバ油と銅化合物との混合系では、低濃度で抗菌・防腐力が高いことが明らかとなった。 Surprisingly, halo was also observed against Candida albicans at the low concentration only in the mixed system of Hiba oil and copper compound. In other words, it became clear that the mixed system of Hiba oil and copper compound has high antibacterial and antiseptic power at low concentrations.
本発明の抗菌・防腐剤および外用組成物は、ヒバ油と銅化合物との混合物を含んでおり、少量にて抗菌・防腐効果を有するため、汎用性に富む。したがって、化粧品、医薬品等の種々の製品に適用することができる。 The antibacterial / preservative and the composition for external use of the present invention contain a mixture of Hiba oil and a copper compound and have an antibacterial / preservative effect in a small amount. Therefore, it can be applied to various products such as cosmetics and pharmaceuticals.
Claims (5)
前記銅化合物は、孔雀石抽出物またはグルコン酸銅であることを特徴とする防腐剤。A preservative containing a mixture of hiba oil and a copper compound ,
The preservative , wherein the copper compound is a peacock stone extract or copper gluconate .
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