JP6326557B1 - 被験物質又は物品が皮膚に与える影響を評価する方法 - Google Patents
被験物質又は物品が皮膚に与える影響を評価する方法 Download PDFInfo
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- JP6326557B1 JP6326557B1 JP2017547588A JP2017547588A JP6326557B1 JP 6326557 B1 JP6326557 B1 JP 6326557B1 JP 2017547588 A JP2017547588 A JP 2017547588A JP 2017547588 A JP2017547588 A JP 2017547588A JP 6326557 B1 JP6326557 B1 JP 6326557B1
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- 239000000126 substance Substances 0.000 title claims abstract description 302
- 238000012360 testing method Methods 0.000 title claims abstract description 228
- 238000000034 method Methods 0.000 title claims abstract description 92
- 230000000694 effects Effects 0.000 title claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 195
- 238000009826 distribution Methods 0.000 claims abstract description 143
- 230000004888 barrier function Effects 0.000 claims abstract description 100
- 230000008859 change Effects 0.000 claims abstract description 72
- 230000008591 skin barrier function Effects 0.000 claims abstract description 39
- 210000003491 skin Anatomy 0.000 claims description 540
- 210000000434 stratum corneum Anatomy 0.000 claims description 78
- 230000035699 permeability Effects 0.000 claims description 75
- 230000002745 absorbent Effects 0.000 claims description 61
- 239000002250 absorbent Substances 0.000 claims description 61
- 238000001069 Raman spectroscopy Methods 0.000 claims description 55
- YNBADRVTZLEFNH-UHFFFAOYSA-N methyl nicotinate Chemical group COC(=O)C1=CC=CN=C1 YNBADRVTZLEFNH-UHFFFAOYSA-N 0.000 claims description 54
- 238000011156 evaluation Methods 0.000 claims description 39
- 239000007864 aqueous solution Substances 0.000 claims description 29
- 229960001238 methylnicotinate Drugs 0.000 claims description 27
- 239000002537 cosmetic Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 12
- 210000002700 urine Anatomy 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 9
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 8
- 239000004615 ingredient Substances 0.000 claims description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000004909 Moisturizer Substances 0.000 claims description 6
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 6
- 230000001333 moisturizer Effects 0.000 claims description 6
- 239000002504 physiological saline solution Substances 0.000 claims description 6
- CELKVAQKCIJCLK-UHFFFAOYSA-N [9-(2-carboxyphenyl)-6-(diethylamino)xanthen-3-ylidene]-diethylazanium;octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC([O-])=O.C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O CELKVAQKCIJCLK-UHFFFAOYSA-N 0.000 claims description 5
- 230000028327 secretion Effects 0.000 claims description 5
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 4
- 235000021466 carotenoid Nutrition 0.000 claims description 4
- 150000001747 carotenoids Chemical class 0.000 claims description 4
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims description 4
- RVYGVBZGSFLJKH-UHFFFAOYSA-N hexyl pyridine-3-carboxylate Chemical compound CCCCCCOC(=O)C1=CC=CN=C1 RVYGVBZGSFLJKH-UHFFFAOYSA-N 0.000 claims description 4
- 229940051295 hexylnicotinate Drugs 0.000 claims description 4
- 235000014655 lactic acid Nutrition 0.000 claims description 4
- 239000004310 lactic acid Substances 0.000 claims description 4
- 229960000448 lactic acid Drugs 0.000 claims description 4
- 239000002953 phosphate buffered saline Substances 0.000 claims description 4
- 229960003471 retinol Drugs 0.000 claims description 4
- 235000020944 retinol Nutrition 0.000 claims description 4
- 239000011607 retinol Substances 0.000 claims description 4
- 238000004566 IR spectroscopy Methods 0.000 claims description 3
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims description 3
- 238000004497 NIR spectroscopy Methods 0.000 claims description 3
- 229960001948 caffeine Drugs 0.000 claims description 3
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 230000001012 protector Effects 0.000 claims 1
- 229920000742 Cotton Polymers 0.000 description 27
- 239000000463 material Substances 0.000 description 25
- 238000005259 measurement Methods 0.000 description 23
- 210000000245 forearm Anatomy 0.000 description 18
- 238000001237 Raman spectrum Methods 0.000 description 16
- 206010015150 Erythema Diseases 0.000 description 12
- 231100000321 erythema Toxicity 0.000 description 12
- 150000002632 lipids Chemical class 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
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- 210000002374 sebum Anatomy 0.000 description 6
- 210000004243 sweat Anatomy 0.000 description 6
- 239000002352 surface water Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
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- 239000012153 distilled water Substances 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
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- 230000029142 excretion Effects 0.000 description 2
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- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
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- 230000005808 skin problem Effects 0.000 description 2
- 239000002344 surface layer Substances 0.000 description 2
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- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 206010012444 Dermatitis diaper Diseases 0.000 description 1
- 208000003105 Diaper Rash Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 238000012888 cubic function Methods 0.000 description 1
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 1
- 229960000943 tartrazine Drugs 0.000 description 1
- 235000012756 tartrazine Nutrition 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2017/015796 WO2018193565A1 (fr) | 2017-04-19 | 2017-04-19 | Procédé d'évaluation de l'impact d'une substance ou d'un produit d'essai sur la peau |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP6326557B1 true JP6326557B1 (ja) | 2018-05-16 |
| JPWO2018193565A1 JPWO2018193565A1 (ja) | 2019-04-25 |
Family
ID=62143843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547588A Active JP6326557B1 (ja) | 2017-04-19 | 2017-04-19 | 被験物質又は物品が皮膚に与える影響を評価する方法 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP6326557B1 (fr) |
| WO (1) | WO2018193565A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020176977A (ja) * | 2019-04-22 | 2020-10-29 | 花王株式会社 | 皮膚バリア機能に与える影響の評価方法 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020193915A (ja) * | 2019-05-29 | 2020-12-03 | 花王株式会社 | 乳幼児の皮膚状態の評価方法 |
| WO2024000232A1 (fr) * | 2022-06-29 | 2024-01-04 | L'oreal | Procédé et dispositif informatique permettant d'évaluer l'effet de protection d'une composition protectrice à appliquer sur la matière kératinique d'un utilisateur |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008510003A (ja) * | 2004-08-19 | 2008-04-03 | アプライド・ジェネティクス・インコーポレーテッド・ダーマティクス | 炎症改善のための生体模倣エボジアルテカルパ果実抽出物 |
| JP2008188302A (ja) * | 2007-02-06 | 2008-08-21 | Shiseido Co Ltd | 美容方法の評価方法 |
| JP2009244259A (ja) * | 2008-03-12 | 2009-10-22 | Kao Corp | 水分量測定方法およびコンタクト剤 |
| JP2014167058A (ja) * | 2013-02-28 | 2014-09-11 | Euglena Co Ltd | 多糖体，皮膚バリア機能改善剤及び皮膚保湿剤 |
-
2017
- 2017-04-19 WO PCT/JP2017/015796 patent/WO2018193565A1/fr active Application Filing
- 2017-04-19 JP JP2017547588A patent/JP6326557B1/ja active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008510003A (ja) * | 2004-08-19 | 2008-04-03 | アプライド・ジェネティクス・インコーポレーテッド・ダーマティクス | 炎症改善のための生体模倣エボジアルテカルパ果実抽出物 |
| JP2008188302A (ja) * | 2007-02-06 | 2008-08-21 | Shiseido Co Ltd | 美容方法の評価方法 |
| JP2009244259A (ja) * | 2008-03-12 | 2009-10-22 | Kao Corp | 水分量測定方法およびコンタクト剤 |
| JP2014167058A (ja) * | 2013-02-28 | 2014-09-11 | Euglena Co Ltd | 多糖体，皮膚バリア機能改善剤及び皮膚保湿剤 |
Non-Patent Citations (1)
| Title |
|---|
| ZHAI, H. ET AL.: "Hydration vs. skin permeability to nicotinates in man", SKIN RESEARCH AND TECHNOLOGY, vol. 8, no. 1, JPN6017026700, February 2002 (2002-02-01), pages 13 - 18, XP055551793, ISSN: 0003683590 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020176977A (ja) * | 2019-04-22 | 2020-10-29 | 花王株式会社 | 皮膚バリア機能に与える影響の評価方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018193565A1 (fr) | 2018-10-25 |
| JPWO2018193565A1 (ja) | 2019-04-25 |
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |