JP6322531B2 - Liquid composition for soft capsule filling - Google Patents

Description

  The present invention relates to a liquid composition for filling soft capsules.

  Soft capsules containing a hardly oil-soluble or powdery active ingredient are generally produced by filling a capsule having gelatin as a coating with a dispersion prepared by dispersing an active ingredient in edible fats and oils. At that time, glycerin fatty acid esters and beeswax have been conventionally used as dispersants for stably dispersing active ingredients in edible fats and oils (see Patent Document 1).

  However, it is known that soft capsules using beeswax as a dispersant have difficulty in elution of active ingredients in vivo, and the effects of active ingredients may not be sufficiently exhibited in vivo. Therefore, a liquid composition for filling soft capsules in which a hardly oil-soluble component is dispersed in edible fats and oils by using a combination of a plurality of emulsifiers such as reactive monoglyceride and distilled monoglyceride without using beeswax (Patent Documents 2 and 2). 5)) has been proposed.

  However, the liquid composition for filling soft capsules still has room for improvement in the dispersibility of the hardly oil-soluble component in edible fats and oils. Some of these soft capsule filling liquid compositions have increased hardness during storage. Once the hardness is increased, filling the soft capsule with the composition requires a treatment to reduce the hardness by stirring or the like, which is not preferable from the viewpoint of production efficiency.

JP 7-138151 A JP 2009-079011 A JP 2009-079012 A JP 2009-242334 A JP 2011-057566 A

  The present invention is a liquid composition for filling soft capsules in which a hardly oil-soluble component is dispersed as an active ingredient in an edible oil and fat, the dispersibility of the hardly oil-soluble component in the edible oil and fat is further improved, and the composition is being stored It is an object of the present invention to provide a soft capsule filling liquid composition in which an increase in hardness is suppressed.

  As a result of intensive studies in order to solve the above problems, the present inventor has found that the above problems can be solved by using four specific types of food emulsifiers, and the present invention is made based on this finding. It came to.

That is, the present invention is a composition in which a hardly oil-soluble component is dispersed in an edible oil and fat, and is a composition in which a hardly oil-soluble component is dispersed in an edible oil and fat, and (a) carbon of a main constituent fatty acid. A reaction monoglyceride having 16 to 20 carbon atoms, (b) a reaction monoglyceride having 22 carbon atoms in the main constituent fatty acid, (c) distilled monoglyceride, and (d) a polyglycerol fatty acid ester having 22 carbon atoms in the main constituent fatty acid. A liquid composition for filling soft capsules,
It is made up of.

The liquid composition for filling soft capsules of the present invention has good dispersion stability of the hardly oil-soluble component in edible fats and oils.
The liquid composition for filling soft capsules of the present invention suppresses the increase in hardness during storage, and therefore does not require a treatment for reducing the hardness in order to fill the soft capsules with the composition.

  Examples of edible oils and fats used in the present invention include rice oil, corn oil, canola oil, olive oil, rice bran oil, soybean oil, soybean white oil, safflower oil, sesame oil, palm oil, palm kernel oil, coconut oil, Sunflower oil, cottonseed oil, rapeseed oil, rapeseed white squeezed oil, vegetable oils such as peanut oil, grape seed oil, and perilla oil, animal fats such as beef fat, pork fat, fish oil, milk fat or lard, medium chain fatty acid triglyceride (MCT) And transesterified oils, fractionated oils, hydrogenated oils, propylene glycol difatty acid esters, and the like. These edible fats and oils can be used alone or in combination of two or more.

  The hardly oil-soluble component used in the present invention is composed of a substance having low lipophilicity and constitutes an active component of the liquid composition for filling soft capsules of the present invention. Specifically, the hardly oil-soluble component in the present invention refers to a substance that is in the form of powder and does not dissolve within 30 minutes when 1 g of the powder is added to 100 g of edible oil and fat and mixed at 20 ° C. .

  Examples of such hardly oil-soluble ingredients include vitamins (especially water-soluble vitamins such as ascorbic acid, vitamins B1, B2, B6, and B12), nutritional supplements such as citric acid, hyaluronic acid, and calcium powder; royal jelly extract Powder (Powder), Propolis Extract Powder, Blueberry Extract Powder, Agaricus Extract Powder, Shark Cartilage Extract Extract Powder, Turmeric Powder, Ginkgo Leaf Extract Powder, Gymnema Extract Powder, Other Animal and Plant Powders, Lactose, Oligosaccharide, Chitosan, Dietary Fiber, etc. Or other medicinal ingredients such as herbal extract powder, Chinese medicine, and pharmaceutical compositions. These hardly oil-soluble components can be used alone or in combination of two or more.

  The reaction monoglyceride referred to in the present invention is obtained by removing as much as possible unreacted glycerin from the esterification reaction product of glycerin and fatty acid or the transesterification reaction product of glycerin and fat (triglyceride). , Monoglyceride (glycerin monofatty acid ester), diglyceride (glycerin difatty acid ester) and triglyceride (glycerin trifatty acid ester). The content of monoglyceride in 100% of the reaction monoglyceride is usually 40 to 60%, preferably 45 to 55%. The content of diglyceride in 100% of the reaction monoglyceride is usually 25 to 45%, preferably 35 to 45%. The content of triglyceride in 100% of the reaction monoglyceride is usually 1 to 15%, preferably 1 to 10%.

The composition of the reaction monoglyceride, that is, the contents of monoglyceride, diglyceride and triglyceride in the reaction monoglyceride can be determined by analyzing the reaction monoglyceride by HPLC (high performance liquid chromatography). Specifically, the reaction moglyceride is analyzed under the analysis conditions shown below, and after the analysis, the peak corresponding to each component of the test sample recorded on the chromatogram by the data processor is used with an integrator. Measure the peak area. Based on the measured peak area, the monoglyceride content, the diglyceride content, and the triglyceride content can be obtained as area percentages.
The HPLC analysis conditions are shown below.

(HPLC analysis conditions)
Apparatus: Shimadzu high-performance liquid chromatograph data processing software (model: LC solution ver. 1.0; manufactured by Shimadzu Corporation)
Pump (Model: LC-20AD; manufactured by Shimadzu Corporation)
Column oven (model: CTO-20A; manufactured by Shimadzu Corporation)
Autosampler (model: SIL-20A; manufactured by Shimadzu Corporation)
Detector: RI detector (model: RID-10A; manufactured by Shimadzu Corporation)
Column: GPC column (model: SHODEX KF-801; manufactured by Showa Denko KK) and GPC column (model: SHODEX KF-802; manufactured by Showa Denko KK), two-linked mobile phase: THF (tetrahydrofuran)
Flow rate: 1.0 mL / min
Column temperature: 40 ° C
Sample concentration: 0.01 g / 1 mL THF
Sample injection volume: 20 μL (in THF)

  As a manufacturing method of the said reaction monoglyceride, the manufacturing method by (1) esterification reaction of glycerol and fats and oils and (2) the manufacturing method by esterification reaction of glycerol and a fatty acid are mentioned, for example. The outline of these production methods is shown in the following (1) and (2), respectively.

(1) Production method of reaction monoglyceride by transesterification For example, in a normal reaction vessel equipped with a stirrer, a heating jacket, a baffle plate, etc., glycerin and fats and oils are charged in a molar ratio of 2: 1. For example, sodium hydroxide is added and stirred and mixed, and the ester exchange reaction is carried out by heating at a temperature of 180 to 260 ° C., preferably 200 to 250 ° C., for 0.5 to 15 hours, preferably 1 to 3 hours in a nitrogen gas atmosphere. Do. The reaction pressure condition is preferably normal pressure or reduced pressure. The obtained reaction liquid is a mixture containing glycerin, monoglyceride, diglyceride, triglyceride and the like.
After completion of the reaction, the catalyst remaining in the reaction solution is neutralized, and then the reaction solution is preferably distilled under reduced pressure to distill off the remaining glycerin. If necessary, desalting, decolorization, filtration, etc. Finally, a reaction monoglyceride containing 40-60% monoglyceride and 25-45% diglyceride is obtained.

(2) Production method of reaction monoglyceride by esterification reaction For example, a normal reaction vessel equipped with a stirrer, a heating jacket, a baffle plate and the like is charged with glycerin and fatty acid at a molar ratio of 1: 1, and an acid or Alkali is added as a catalyst and under any inert gas atmosphere such as nitrogen or carbon dioxide, for example in the range of 180-260 ° C, preferably 200-250 ° C for 0.5-5 hours, preferably 1-3 hours. Esterification reaction is performed by heating. The obtained reaction liquid is a mixture containing glycerin, monoglyceride, diglyceride, triglyceride and the like.
After completion of the reaction, the catalyst remaining in the reaction solution is neutralized, and then the reaction solution is preferably distilled under reduced pressure to distill off the remaining glycerin. If necessary, desalting, decolorization, filtration, etc. Finally, a reaction monoglyceride containing 40-60% monoglyceride and 25-45% diglyceride is obtained.

  In the present invention, among the above-mentioned reaction monoglycerides, a reaction monoglyceride having 16 to 20 carbon atoms in the main constituent fatty acid and a reaction monoglyceride having 22 carbon atoms in the main constituent fatty acid are used in combination. Examples of the reactive monoglyceride having 16 to 20 carbon atoms in the main constituent fatty acid include, for example, a reactive monoglyceride in which the main constituent fatty acid is palmitic acid (16 carbon atoms), a reactive monoglyceride in which the main constituent fatty acid is stearic acid (18 carbon atoms), and a main constituent fatty acid. Is a reaction monoglyceride of arachidic acid (carbon number 20). Among them, a reaction monoglyceride in which the main constituent fatty acid is palmitic acid and / or stearic acid is preferable. Moreover, as a reaction monoglyceride whose carbon number of a main constituent fatty acid is 22, the reaction monoglyceride whose main constituent fatty acid is behenic acid is mentioned.

  In the present invention, the “main constituent fatty acid” in the reaction monoglyceride means a fatty acid occupying 60% by mass or more, preferably 75% by mass or more, in 100% by mass of the total fatty acids constituting the reaction monoglyceride. Therefore, for example, the reaction monoglyceride having 16 to 18 carbon atoms of the main constituent fatty acid is one in which the fatty acid contained in the range of 16 to 18 carbon atoms occupies 60 mass% or more in 100 mass% of all fatty acids constituting the reaction monoglyceride. means. Similarly, the reaction monoglyceride having 18 carbon atoms of the main constituent fatty acid means that the fatty acid having 18 carbon atoms (that is, stearic acid, etc.) accounts for 60 mass% or more in 100 mass% of the total fatty acids constituting the reaction monoglyceride. To do. The definition of “main constituent fatty acid” for the distilled monoglyceride and polyglycerin fatty acid ester described later is the same as this.

  Examples of the reaction monoglyceride having 16 to 20 carbon atoms of the main constituent fatty acid include Poem P-200 (product name; 16 to 18 carbon atoms of the main constituent fatty acid; monoglyceride content: about 52%; manufactured by Riken Vitamin Co., Ltd.), Poem V-200 (product name; carbon number of main constituent fatty acid: 18; monoglyceride content: about 50%; manufactured by Riken Vitamin Co., Ltd.) and the like are commercially produced and sold. In the present invention, these commercially available products may be used. it can. In addition, as the reaction monoglyceride having 22 carbon atoms in the main constituent fatty acid, Poem B-200 (product name; monoglyceride content: about 47%; manufactured by Riken Vitamin Co., Ltd.) is commercially produced and sold. Then, these commercially available products can be used.

  The distilled monoglyceride used in the present invention is obtained by purifying the reaction monoglyceride obtained by the above-described production method and increasing the monoglyceride content. The content of monoglyceride in 100% of the distilled monoglyceride is usually 90% or more. Although there is no restriction | limiting in particular in the fatty acid which comprises the distilled monoglyceride used by this invention, For example, a C6-C24 linear saturated fatty acid (for example, caproic acid, caprylic acid, capric acid originated from edible animal and vegetable fats and oils) Lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignoceric acid) and the like, more preferably palmitic acid, stearic acid, and behenic acid.

  The content of monoglyceride in 100% of the distilled monoglyceride is determined by analyzing using HPLC under the above analysis conditions. Specifically, after analyzing the distilled monoglyceride under the above HPLC analysis conditions, the peak area corresponding to each component of the test sample recorded on the chromatogram by the data processor is measured using an integrator, Based on the measured peak area, the monoglyceride content can be determined as an area percentage.

  The distilled monoglyceride used in the present invention can be produced by purifying the above-described reaction monoglyceride. Examples of the purification method include a vacuum distillation method using a falling film molecular distillation apparatus or a centrifugal molecular distillation apparatus. By purifying using these methods, a distilled monoglyceride containing 90% or more of the whole monoglyceride can be obtained. The upper limit of the monoglyceride content in the distilled monoglyceride is usually about 99%.

  Examples of the distilled monoglyceride include Emulsy P-100 (product name: 16 to 18 carbon atoms of main constituent fatty acid; monoglyceride content: about 98%; manufactured by Riken Vitamin Co., Ltd.), Poem S-100 (product name: main constituent fatty acid) Carbon number 18; monoglyceride content about 98%; manufactured by Riken Vitamin Co., Ltd.), Poem B-100 (product name; carbon number 22 of main constituent fatty acid; monoglyceride content about 96%; manufactured by Riken Vitamin Co., Ltd.) These are manufactured and sold and can be used in the present invention.

  The polyglycerol fatty acid ester having 22 carbon atoms of the main constituent fatty acid used in the present invention is an esterification reaction product of polyglycerol and behenic acid and can be produced by a method known per se such as an esterification reaction.

  As the polyglycerol used as a raw material of the polyglycerol fatty acid ester having 22 carbon atoms of the main constituent fatty acid used in the present invention, a small amount of acid or alkali is usually added to glycerol as a catalyst, and any of nitrogen, carbon dioxide and the like For example, a mixture of polyglycerin having different degrees of polymerization obtained by heating at a temperature of about 180 ° C. or higher under an inert gas atmosphere to cause a polycondensation reaction may be mentioned. Polyglycerin may be obtained using glycidol or epichlorohydrin as a raw material. After completion of the reaction, a treatment such as neutralization, desalting or decolorization may be performed if necessary. Examples of the polyglycerin include polyglycerin having an average degree of polymerization of glycerin of usually about 2 to 20, preferably about 2 to 15. Specifically, for example, diglycerin (average polymerization degree: about 2.0), triglycerin (average polymerization degree: about 3.0), tetraglycerin (average polymerization degree: about 4.0), hexaglycerin (average polymerization) Degree: about 6.0), octaglycerin (average degree of polymerization: about 8.0), decaglycerin (average degree of polymerization: about 10.0) and the like, and triglycerin and tetraglycerin are particularly preferred.

  The behenic acid used as a raw material for the polyglycerol fatty acid ester having 22 carbon atoms of the main constituent fatty acid used in the present invention is not particularly limited, but preferably has a purity of 50% or more. When the purity is 50% or more, sufficient dispersion stability of the hardly oil-soluble component can be obtained.

  The outline of the preferable manufacturing method of the polyglycerol fatty acid ester whose carbon number of the main constituent fatty acid used in the present invention is 22 is as follows. For example, when triglycerin is used as polyglycerin, triglycerin and behenic acid are charged in a molar ratio of about 1: 2 to 1: 3 in a normal reaction vessel equipped with a stirrer, a heating jacket, a baffle plate, and the like. Usually, sodium hydroxide is added as a catalyst and stirred and mixed, and heated at a predetermined temperature in a nitrogen gas atmosphere while removing water generated by the esterification reaction out of the system. The reaction temperature is usually in the range of 180 to 260 ° C, preferably in the range of 200 to 250 ° C. The reaction pressure condition is normal pressure or reduced pressure, and the reaction time is 0.5 to 15 hours, preferably 1 to 3 hours. The end point of the reaction is usually determined by measuring the acid value of the reaction mixture and about 12 or less.

  After completion of the esterification reaction, the catalyst remaining in the reaction mixture is neutralized as necessary, and if necessary, treatments such as desalting, decoloring, and filtration are performed, and finally, the carbon of the main constituent fatty acid of the present invention A polyglycerol fatty acid ester of 22 is obtained.

  Examples of the polyglycerol fatty acid ester having 22 main constituent fatty acids include Poem HB (trade name; triglycerin fatty acid ester; manufactured by Riken Vitamin Co., Ltd.), Poem J-46B (trade name; tetraglycerin fatty acid ester; RIKEN vitamin) Etc.) are commercially produced and sold, and these can be used in the present invention.

  As long as the liquid composition for filling soft capsules of the present invention exhibits the effects of the present invention, the edible oil and fat, the hardly oil-soluble component, the reactive monoglyceride having 16 to 20 carbon atoms of the main constituent fatty acid, Other components other than the reaction monoglyceride having 22 carbon atoms, the distilled monoglyceride, and the polyglycerol fatty acid ester having 22 carbon atoms of the main constituent fatty acid may be included.

  Examples of other components include diglycerin fatty acid esters having a monoester content of 50% or more, antioxidants (for example, extracted tocopherol, ascorbyl palmitate), and the like. Other components can be used alone or in combination of two or more.

  In addition, when the diglycerin fatty acid ester having a monoester content of 50% or more is used as the other component in the soft capsule filling liquid composition of the present invention, when the soft capsule filled with the composition is ingested, It is preferable because the hardly oil-soluble component is easily dispersed in the gastric juice and the absorption of the active ingredient into the living body can be expected to be accelerated.

  The liquid composition for filling soft capsules of the present invention comprises the above edible oil and fat, a hardly oil-soluble component, a reactive monoglyceride having 16 to 20 carbon atoms in the main constituent fatty acid, a reactive monoglyceride having 22 carbon atoms in the main constituent fatty acid, a distilled monoglyceride, It is produced by uniformly dispersing these components while mixing and stirring a polyglycerol fatty acid ester having 22 carbon atoms in the constituent fatty acid and, if necessary, a diester fatty acid ester having a monoester content of 50% or more. The Specifically, for example, edible fats and oils, a reaction monoglyceride having 16 to 20 carbon atoms in the main constituent fatty acid, a reaction monoglyceride having 22 carbon atoms in the main constituent fatty acid, a distilled monoglyceride, and a polyglycerol having 22 carbon atoms in the main constituent fatty acid. Fatty acid esters and diglycerin fatty acid esters having a monoester content of 50% or more as necessary are heated to, for example, 60 to 90 ° C., preferably 70 to 80 ° C., and uniformly mixed and stirred to obtain a solution. After the preparation, the solution is cooled to 40 to 60 ° C., for example, and the hardly oil-soluble component is added, mixed and stirred, and the hardly oil-soluble component is uniformly dispersed. In addition, the reaction monoglyceride having 16 to 20 carbon atoms of the main constituent fatty acid, the reaction monoglyceride having 22 carbon atoms of the main constituent fatty acid, the distilled monoglyceride, the polyglycerol fatty acid ester having the main constituent fatty acid of 22 carbon atoms, and the monoester content However, the diglycerin fatty acid ester of 50% or more may be prepared by mixing these in advance and heating and melting them. Although there is no restriction | limiting in particular in the apparatus for mixing and stirring, For example, high-speed stirrers, such as a biomixer and a homojetter, or a high-speed grinder can be used.

  The content of the edible fat / oil in 100% by mass of the liquid composition for filling soft capsules of the present invention is not particularly limited, but is usually 20 to 95% by mass, preferably 25 to 90% by mass, and more preferably 30 to 80% by mass. It is. In the present invention, if the content of the edible oil / fat is in the above range, the hardly oil-soluble component can be sufficiently dispersed in the edible oil / fat, and the dispersion stability of the hardly oil-soluble component in the edible oil / fat is good.

  The content of the hardly oil-soluble component in 100% by mass of the liquid composition for filling soft capsules of the present invention is not particularly limited, but is usually 1 to 70% by mass, preferably 3 to 60% by mass, more preferably 10 to 10% by mass. 50% by mass. If content of a hardly oil-soluble component is the said range in this invention, a hardly oil-soluble component can fully be disperse | distributed in edible fats and oils. Moreover, since the dispersion stability of the hardly oil-soluble component in the edible fat is good, the hardly oil-soluble component is not separated in the soft capsule.

  The content of the reaction monoglyceride having 16 to 20 carbon atoms of the main constituent fatty acid in 100% by mass of the liquid composition for filling soft capsules of the present invention is not particularly limited, but is usually 0.25 to 14% by mass, preferably, for example. It is 0.25-10 mass%, More preferably, it is 0.5-8 mass%. In the present invention, if the content of the reactive monoglyceride is in the above range, the dispersion stability of the hardly oil-soluble component in the edible fat is good, so that the hardly oil-soluble component is not separated in the soft capsule. In addition, an increase in hardness during storage of the liquid composition for filling soft capsules is suppressed, and the process of filling the soft capsules with the composition becomes easy.

  The content of the reaction monoglyceride having 22 carbon atoms of the main constituent fatty acid in 100% by mass of the liquid composition for filling soft capsules of the present invention is not particularly limited, but is usually 0.25 to 14% by mass, preferably 0.00. It is 25-10 mass%, More preferably, it is 0.5-8 mass%. In the present invention, if the content of the reactive monoglyceride is in the above range, the dispersion stability of the hardly oil-soluble component in the edible fat is good, so that the hardly oil-soluble component is not separated in the soft capsule. In addition, an increase in hardness during storage of the liquid composition for filling soft capsules is suppressed, and the process of filling the soft capsules with the composition becomes easy.

  The content of the distilled monoglyceride in 100% by mass of the liquid composition for filling soft capsules of the present invention is not particularly limited, but is usually 0.5 to 15% by mass, preferably 0.5 to 10% by mass, and more preferably. 1 to 8% by mass. In the present invention, when the content of the distilled monoglyceride is in the above range, the dispersion stability of the hardly oil-soluble component in the edible fat is good, and therefore the hardly oil-soluble component is not separated in the soft capsule. In addition, an increase in hardness during storage of the liquid composition for filling soft capsules is suppressed, and the process of filling the soft capsules with the composition becomes easy.

  The content of the polyglycerol fatty acid ester having 22 carbon atoms of the main constituent fatty acid in 100% by mass of the liquid composition for filling soft capsules of the present invention is not particularly limited, but is usually 0.25 to 14% by mass, preferably, for example. It is 0.25-10 mass%, More preferably, it is 0.5-8 mass%. In the present invention, when the content of the distilled monoglyceride is in the above range, the dispersion stability of the hardly oil-soluble component in the edible fat is good, and therefore the hardly oil-soluble component is not separated in the soft capsule. In addition, an increase in hardness during storage of the liquid composition for filling soft capsules is suppressed, and the process of filling the soft capsules with the composition becomes easy.

  When a diglycerin fatty acid ester having a monoester content of 50% or more is used in the liquid composition for filling soft capsules of the present invention, the diglycerin fatty acid having a monoester content of 50% or more in 100% by mass of the composition is used. Although content of ester is not specifically limited, For example, it is 0.05-1.5 mass% normally, Preferably, it is 0.05-1 mass%, More preferably, it is 0.1-1 mass%. In the present invention, when the content of the diglycerin fatty acid ester is within the above range, the poorly oil-soluble component is sufficiently dispersed in the living body (for example, in the gastric juice). It can be expected to be fully used.

  Soft capsules can be produced by wrapping the thus obtained liquid composition for filling soft capsules with a film mainly composed of gelatin according to a conventional method. Specifically, for example, a soft capsule can be produced by a method of injecting a predetermined amount of a liquid composition for filling a soft capsule between two gelatin sheets and punching it out.

  Hereinafter, the present invention will be described more specifically based on examples, but the present invention is not limited thereto.

[Preparation of liquid composition for soft capsule filling]
(1) Raw materials for preparation of liquid composition for soft capsule filling 1) Rapeseed salad oil (manufactured by J-Oil Mills)
2) Corn starch (manufactured by Sanwa Starch Kogyo Co., Ltd.)
3) Riboflavin (manufactured by Riken Vitamin)
4) Reaction monoglyceride having 16 to 18 carbon atoms of main constituent fatty acid (trade name: Poem P-200; monoglyceride content: about 52%; manufactured by Riken Vitamin Co., Ltd.)
5) Reaction monoglyceride whose main constituent fatty acid has 18 carbon atoms (trade name: Poem V-200; monoglyceride content: about 50%; manufactured by Riken Vitamin Co., Ltd.)
6) Reaction monoglyceride whose main constituent fatty acid has 22 carbon atoms (trade name: Poem B-200; monoglyceride content: about 47%; manufactured by Riken Vitamin Co., Ltd.)
7) Distilled monoglyceride (trade name: Emulsy P-100; monoglyceride content: about 98%; manufactured by Riken Vitamin Co., Ltd.)
8) Distilled monoglyceride (trade name: Poem S-100; monoglyceride content: about 98%; manufactured by Riken Vitamin Co., Ltd.)
9) Polyglycerin fatty acid ester having 22 carbon atoms in the main constituent fatty acid (trade name: Poem HB; triglycerin fatty acid ester; manufactured by Riken Vitamin Co., Ltd.)
10) Polyglycerin fatty acid ester having 22 main constituent fatty acids (trade name: Poem J-46B; tetraglycerin fatty acid ester; manufactured by Riken Vitamin Co., Ltd.)

(2) Composition of raw materials Table 1 shows the composition of raw materials used for the preparation of liquid compositions for filling soft capsules (Examples 1 to 4 and Comparative products 1 to 5). Of these, Examples 1 to 4 are examples according to the present invention, and Comparative Examples 1 to 5 are comparative examples for them.

(3) Preparation of liquid composition for filling soft capsules Based on the formulation shown in Table 1, a liquid composition for filling soft capsules was prepared. That is, a reaction monoglyceride having 16 to 20 carbon atoms of the main constituent fatty acid, a reaction monoglyceride having 22 carbon atoms of the main constituent fatty acid, a distilled monoglyceride, and a polyglycerol fatty acid ester having 22 carbon atoms of the main constituent fatty acid are added to the rapeseed salad oil, This was heated to 80 ° C. and stirred to dissolve these food emulsifiers in the salad oil. The obtained lysate was cooled to 50 ° C. in a water bath, and this was stirred at 8000 rpm using a mixer (model: Ultra Turrax T-25 Basic; manufactured by IKA Japan) at room temperature. In addition, the mixture was further stirred at 8000 rpm for 10 minutes to obtain a dispersion in which corn starch and riboflavin were dispersed in salad oil. At this time, the temperature of the solution or dispersion was appropriately adjusted using hot water or cold water so that the temperature of the solution or dispersion was 40 to 50 ° C. The obtained dispersion was vacuum degassed and then cooled to 25 ° C. in a water bath to obtain about 150 g of a liquid composition for filling soft capsules (Examples 1 to 4 and Comparative products 1 to 5).

(4) Evaluation of liquid composition for filling soft capsules The following evaluation tests were performed on each of the liquid compositions for filling soft capsules (Examples 1 to 4 and Comparative Examples 1 to 5) prepared by the above-described method. The results are shown in Table 2.

[Evaluation of separation of hardly oil-soluble components]
50 g of each of the liquid compositions for filling soft capsules (implemented products 1 to 4 and comparative products 1 to 5) is put into a centrifuge tube (capacity 50 mL; made of plastic), and this is centrifuged (model: SL-IV; manufactured by Sakuma Seisakusho). ), And centrifuged at 3000 rpm for 15 minutes. Thereafter, the centrifuge tube was taken out from the centrifuge, and the presence or absence of separation of the hardly oil-soluble components (corn starch and riboflavin) was visually observed in the centrifuge tube sample.

[Evaluation of hardness]
Each of the liquid compositions for filling soft capsules (Examples 1 to 4 and Comparative products 1 to 5) was filled into a plastic truncated cone-shaped container (capacity 90 mL; inner diameter: upper part 65 mm, bottom part 45 mm) at 25 ° C. After storage for 24 hours, the hardness was measured. For the measurement of hardness, a texture analyzer (model: EZ-Test; φ14 cylindrical jig mounted; entry speed 120 mm / min; manufactured by Shimadzu Corporation) was used, and the cylindrical jig was placed 10 mm from the surface of the composition to the inside. The maximum stress (N) measured before entering was determined as the hardness.

  As is clear from the results in Table 2, none of the Examples 1 to 4 caused separation of the hardly oil-soluble component, and their hardness was suppressed to 1.21 N at the maximum. On the other hand, in comparative products 1 to 4, separation of the hardly oil-soluble component occurred, and in particular, the hardness of comparative product 4 increased to 2.52N. Further, in Comparative product 5, the hardly oil-soluble component was not separated, but the hardness increased to 2.00 N. That is, Comparative products 1 to 5 were all unsuitable for use in soft capsules.

Claims (1)

  A composition in which a hardly oil-soluble component is dispersed in an edible fat, and (a) a reactive monoglyceride having 16 to 20 carbon atoms in the main constituent fatty acid, (b) a reactive monoglyceride having 22 carbon atoms in the main constituent fatty acid, A liquid composition for filling soft capsules comprising (c) distilled monoglyceride and (d) a polyglycerol fatty acid ester having 22 main constituent fatty acids.