JP6322530B2 - Liquid composition for soft capsule filling - Google Patents
Liquid composition for soft capsule filling Download PDFInfo
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- JP6322530B2 JP6322530B2 JP2014187555A JP2014187555A JP6322530B2 JP 6322530 B2 JP6322530 B2 JP 6322530B2 JP 2014187555 A JP2014187555 A JP 2014187555A JP 2014187555 A JP2014187555 A JP 2014187555A JP 6322530 B2 JP6322530 B2 JP 6322530B2
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- monoglyceride
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- 239000000203 mixture Substances 0.000 title claims description 59
- 239000007901 soft capsule Substances 0.000 title claims description 56
- 238000011049 filling Methods 0.000 title claims description 43
- 239000007788 liquid Substances 0.000 title claims description 39
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 113
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 70
- 229930195729 fatty acid Natural products 0.000 claims description 70
- 239000000194 fatty acid Substances 0.000 claims description 70
- 150000004665 fatty acids Chemical class 0.000 claims description 56
- 239000000470 constituent Substances 0.000 claims description 46
- 125000004432 carbon atom Chemical group C* 0.000 claims description 40
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 description 42
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 31
- 239000003925 fat Substances 0.000 description 31
- 235000019197 fats Nutrition 0.000 description 30
- 239000003921 oil Substances 0.000 description 22
- 235000019198 oils Nutrition 0.000 description 21
- 239000000047 product Substances 0.000 description 19
- 229940088594 vitamin Drugs 0.000 description 18
- 229930003231 vitamin Natural products 0.000 description 18
- -1 glycerin fatty acid esters Chemical class 0.000 description 16
- 235000011187 glycerol Nutrition 0.000 description 15
- 238000004519 manufacturing process Methods 0.000 description 14
- 239000000843 powder Substances 0.000 description 14
- 238000000034 method Methods 0.000 description 13
- 239000006185 dispersion Substances 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 11
- 239000008157 edible vegetable oil Substances 0.000 description 10
- 229940105990 diglycerin Drugs 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 8
- 238000004128 high performance liquid chromatography Methods 0.000 description 8
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 238000005886 esterification reaction Methods 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
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- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 4
- 240000008415 Lactuca sativa Species 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
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- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
- 238000000199 molecular distillation Methods 0.000 description 4
- 235000019192 riboflavin Nutrition 0.000 description 4
- 229960002477 riboflavin Drugs 0.000 description 4
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- 235000012045 salad Nutrition 0.000 description 4
- 240000002791 Brassica napus Species 0.000 description 3
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 235000021355 Stearic acid Nutrition 0.000 description 3
- 235000013871 bee wax Nutrition 0.000 description 3
- 239000012166 beeswax Substances 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000008117 stearic acid Substances 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 235000021357 Behenic acid Nutrition 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 235000021314 Palmitic acid Nutrition 0.000 description 2
- 229940116226 behenic acid Drugs 0.000 description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 238000004042 decolorization Methods 0.000 description 2
- 238000011033 desalting Methods 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 239000011552 falling film Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 235000003084 food emulsifier Nutrition 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- 238000005809 transesterification reaction Methods 0.000 description 2
- 238000005292 vacuum distillation Methods 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 241000222518 Agaricus Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 244000163122 Curcuma domestica Species 0.000 description 1
- 235000003392 Curcuma domestica Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000009429 Ginkgo biloba extract Substances 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 241000208251 Gymnema Species 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 235000021353 Lignoceric acid Nutrition 0.000 description 1
- CQXMAMUUWHYSIY-UHFFFAOYSA-N Lignoceric acid Natural products CCCCCCCCCCCCCCCCCCCCCCCC(=O)OCCC1=CC=C(O)C=C1 CQXMAMUUWHYSIY-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 241000241413 Propolis Species 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 235000019774 Rice Bran oil Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 229940055416 blueberry extract Drugs 0.000 description 1
- 235000019216 blueberry extract Nutrition 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000000828 canola oil Substances 0.000 description 1
- 235000019519 canola oil Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
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- 235000003373 curcuma longa Nutrition 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- FARYTWBWLZAXNK-WAYWQWQTSA-N ethyl (z)-3-(methylamino)but-2-enoate Chemical compound CCOC(=O)\C=C(\C)NC FARYTWBWLZAXNK-WAYWQWQTSA-N 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000008169 grapeseed oil Substances 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 235000021243 milk fat Nutrition 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
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- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
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- 238000004080 punching Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 229940007115 shark cartilage extract Drugs 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Description
本発明は、ソフトカプセル充填用液状組成物に関する。 The present invention relates to a liquid composition for filling soft capsules.
難油溶性や粉末状の有効成分を含有するソフトカプセル剤は、一般に、有効成分を食用油脂に分散して調製した分散液を、ゼラチンを皮膜とするカプセルに充填して製造される。その際、有効成分を食用油脂中に安定に分散させるための分散剤として、従来グリセリン脂肪酸エステルやミツロウが使用されている（特許文献１参照）。 Soft capsules containing a hardly oil-soluble or powdery active ingredient are generally produced by filling a capsule having gelatin as a coating with a dispersion prepared by dispersing an active ingredient in edible fats and oils. At that time, glycerin fatty acid esters and beeswax have been conventionally used as dispersants for stably dispersing active ingredients in edible fats and oils (see Patent Document 1).
しかし、分散剤にミツロウを使用したソフトカプセル剤は、生体内での有効成分の溶出に難があり、有効成分の効果が生体内で十分に発揮されないおそれがあることが知られている。そこで、ミツロウを使用せず、反応モノグリセライドや蒸留モノグリセライド等の複数種類の乳化剤を組合せて使用することにより、食用油脂中に難油溶性成分を分散せしめたソフトカプセル充填用液状組成物（特許文献２〜５参照）等が提案されている。 However, it is known that soft capsules using beeswax as a dispersant have difficulty in elution of active ingredients in vivo, and the effects of active ingredients may not be sufficiently exhibited in vivo. Therefore, a liquid composition for filling soft capsules in which a hardly oil-soluble component is dispersed in edible fats and oils by using a combination of a plurality of emulsifiers such as reactive monoglyceride and distilled monoglyceride without using beeswax (Patent Documents 2 and 2). 5)) has been proposed.
しかし、上記ソフトカプセル充填用液状組成物は、食用油脂中の難油溶性成分の分散性において、なお改善の余地が残されている。また、このようなソフトカプセル充填用液状組成物には、保存中に硬度が上昇するものがある。一旦硬度が上昇すると、該組成物をソフトカプセルに充填するには、撹拌等により硬度を低減させる処理が必要になるため、製造効率の点から好ましくない。 However, the liquid composition for filling soft capsules still has room for improvement in the dispersibility of the hardly oil-soluble component in edible fats and oils. Some of these soft capsule filling liquid compositions have increased hardness during storage. Once the hardness is increased, filling the soft capsule with the composition requires a treatment to reduce the hardness by stirring or the like, which is not preferable from the viewpoint of production efficiency.
本発明は、食用油脂中に有効成分として難油溶性成分を分散せしめたソフトカプセル充填用液状組成物であって、食用油脂中での難油溶性成分の分散性がさらに改善され、且つ保存中の硬度の上昇が抑制されたソフトカプセル充填用液状組成物を提供することを課題とする。 The present invention is a liquid composition for filling soft capsules in which a hardly oil-soluble component is dispersed as an active ingredient in an edible oil and fat, the dispersibility of the hardly oil-soluble component in the edible oil and fat is further improved, and the composition is being stored It is an object of the present invention to provide a soft capsule filling liquid composition in which an increase in hardness is suppressed.
本発明者は、上記課題を解決するため、鋭意検討した結果、特定の３種類の食品用乳化剤を使用することにより、上記課題が解決されることを見出し、この知見に基づいて本発明をなすに至った。 As a result of intensive studies to solve the above problems, the present inventors have found that the above problems can be solved by using three specific types of food emulsifiers. The present invention is made based on this finding. It came to.
即ち、本発明は、食用油脂中に難油溶性成分を分散せしめた組成物であって、（ａ）反応モノグリセライド、（ｂ）主構成脂肪酸の炭素数が１６〜２０の蒸留モノグリセライド及び（ｃ）主構成脂肪酸の炭素数が２２の蒸留モノグリセライドを含有することを特徴とするソフトカプセル充填用液状組成物、
からなっている。
That is, the present invention is a composition in which a hardly oil-soluble component is dispersed in an edible fat, and (a) a reactive monoglyceride, (b) a distilled monoglyceride having 16 to 20 carbon atoms in a main constituent fatty acid, and (c) A liquid composition for filling soft capsules, characterized in that it contains a distilled monoglyceride whose main constituent fatty acid has 22 carbon atoms,
It is made up of.
本発明のソフトカプセル充填用液状組成物は、食用油脂中での難油溶性成分の分散安定性が良好である。
本発明のソフトカプセル充填用液状組成物は、保存中の硬度の上昇が抑制されているため、該組成物をソフトカプセルに充填するために硬度を低減させる処理が不要である。
The liquid composition for filling soft capsules of the present invention has good dispersion stability of the hardly oil-soluble component in edible fats and oils.
The liquid composition for filling soft capsules of the present invention suppresses the increase in hardness during storage, and therefore does not require a treatment for reducing the hardness in order to fill the soft capsules with the composition.
本発明で用いられる食用油脂としては、例えばコメ油、コーン油、キャノーラ油、オリーブ油、米ぬか油、大豆油、大豆白絞油、サフラワー油、ごま油、パーム油、パーム核油、やし油、ヒマワリ油、綿実油、菜種油、菜種白絞油、落花生油、グレープシード油、しそ油等の植物性油脂、牛脂、豚脂、魚油、乳脂又はラード等の動物性油脂、中鎖脂肪酸トリグリセリド（ＭＣＴ）及びこれらのエステル交換油、分別油、水素添加油又はプロピレングリコールジ脂肪酸エステル等が挙げられる。これら食用油脂は、１種又は２種以上を任意に組み合わせて用いることができる。 Examples of edible oils and fats used in the present invention include rice oil, corn oil, canola oil, olive oil, rice bran oil, soybean oil, soybean white oil, safflower oil, sesame oil, palm oil, palm kernel oil, coconut oil, Sunflower oil, cottonseed oil, rapeseed oil, rapeseed white squeezed oil, vegetable oils such as peanut oil, grape seed oil, and perilla oil, animal fats such as beef fat, pork fat, fish oil, milk fat or lard, medium chain fatty acid triglyceride (MCT) And transesterified oils, fractionated oils, hydrogenated oils, propylene glycol difatty acid esters, and the like. These edible fats and oils can be used alone or in combination of two or more.
本発明で用いられる難油溶性成分は、親油性の低い物質から構成され、本発明のソフトカプセル充填用液状組成物の有効成分を構成するものである。具体的には、本発明における難油溶性成分とは、粉末の形態であって、食用油脂１００ｇに該粉末１ｇを入れ２０℃で混合したとき、３０分以内に溶解しない物質を指すものとする。 The hardly oil-soluble component used in the present invention is composed of a substance having low lipophilicity and constitutes an active component of the liquid composition for filling soft capsules of the present invention. Specifically, the hardly oil-soluble component in the present invention refers to a substance that is in the form of powder and does not dissolve within 30 minutes when 1 g of the powder is added to 100 g of edible oil and fat and mixed at 20 ° C. .
このような難油溶性成分としては、例えば、ビタミン類（特にアスコルビン酸、ビタミンＢ１、Ｂ２、Ｂ６、Ｂ１２等の水溶性ビタミン）、クエン酸、ヒアルロン酸、カルシウムパウダー等の栄養補助成分；ローヤルゼリーエキス末（粉末）、プロポリスエキス末、ブルーベリーエキス末、アガリクスエキス末、サメ軟骨抽出エキス末、ウコン末、イチョウ葉エキス末、ギムネマエキス末、その他の動植物粉末、乳糖、オリゴ糖、キトサン、食物繊維等の健康食品成分；或いは生薬エキス末、漢方、医薬組成物等の薬効成分が挙げられる。これら難油溶性成分は１種又は２種以上を任意に組み合わせて用いることができる。 Examples of such hardly oil-soluble ingredients include vitamins (especially water-soluble vitamins such as ascorbic acid, vitamins B1, B2, B6, and B12), nutritional supplements such as citric acid, hyaluronic acid, and calcium powder; royal jelly extract Powder (Powder), Propolis Extract Powder, Blueberry Extract Powder, Agaricus Extract Powder, Shark Cartilage Extract Powder, Turmeric Powder, Ginkgo Leaf Extract Powder, Gymnema Extract Powder, Other Animal and Plant Powders, Lactose, Oligosaccharide, Chitosan, Dietary Fiber, etc. Or other medicinal ingredients such as herbal extract powder, Chinese medicine, and pharmaceutical compositions. These hardly oil-soluble components can be used alone or in combination of two or more.
本発明で用いられる反応モノグリセライドは、グリセリンと脂肪酸とのエステル化反応生成物又はグリセリンと油脂（トリグリセライド）とのエステル交換反応生成物から未反応のグリセリンを可及的に除去したものであって、モノグリセライド（グリセリンモノ脂肪酸エステル）、ジグリセライド（グリセリンジ脂肪酸エステル）及びトリグリセライド（グリセリントリ脂肪酸エステル）を含有する混合物である。該反応モノグリセライド１００％中のモノグリセライドの含有量は、通常４０〜６０％であり、好ましくは４５〜５５％である。また、反応モノグリセライド１００％中のジグリセライドの含有量は、通常２５〜４５％であり、好ましくは３５〜４５％である。反応モノグリセライド１００％中のトリグリセライドの含有量は、通常１〜１５％であり、好ましくは１〜１０％である。 The reaction monoglyceride used in the present invention is obtained by removing as much as possible unreacted glycerin from the esterification reaction product of glycerin and fatty acid or the transesterification reaction product of glycerin and fat (triglyceride), It is a mixture containing monoglyceride (glycerin monofatty acid ester), diglyceride (glycerin difatty acid ester) and triglyceride (glycerin trifatty acid ester). The content of monoglyceride in 100% of the reaction monoglyceride is usually 40 to 60%, preferably 45 to 55%. Further, the content of diglyceride in 100% of the reaction monoglyceride is usually 25 to 45%, preferably 35 to 45%. The content of triglyceride in 100% of the reaction monoglyceride is usually 1 to 15%, preferably 1 to 10%.
上記反応モノグリセライドの組成、すなわち反応モノグリセライド中のモノグリセライド、ジグリセライド及びトリグリセライドの含有量は、反応モノグリセライドをＨＰＬＣ（高速液体クロマトグラフィー）で分析することにより求められる。具体的には、以下に示す分析条件にて反応モグリセライドを分析し、分析後、データ処理装置によりクロマトグラム上に記録された被検試料の各成分に対応するピークについて、積分計を用いてピーク面積を測定する。測定されたピーク面積に基づいて、面積百分率としてモノグリセライド含有量、ジグリセライド含有量及びトリグリセライド含有量を求めることができる。
ＨＰＬＣ分析条件を以下に示す。
The composition of the reaction monoglyceride, that is, the contents of monoglyceride, diglyceride and triglyceride in the reaction monoglyceride can be determined by analyzing the reaction monoglyceride by HPLC (high performance liquid chromatography). Specifically, the reaction moglyceride is analyzed under the analysis conditions shown below, and after the analysis, the peak corresponding to each component of the test sample recorded on the chromatogram by the data processor is used with an integrator. Measure the peak area. Based on the measured peak area, the monoglyceride content, the diglyceride content, and the triglyceride content can be obtained as area percentages.
The HPLC analysis conditions are shown below.
（ＨＰＬＣ分析条件）
装置：島津高速液体クロマトグラフ
データ処理ソフトウェア（型式：ＬＣｓｏｌｕｔｉｏｎ ｖｅｒ．１．０；島津製作所社製）
ポンプ（型式：ＬＣ−２０ＡＤ；島津製作所社製）
カラムオーブン（型式：ＣＴＯ−２０Ａ；島津製作所社製）
オートサンプラ（型式：ＳＩＬ−２０Ａ；島津製作所社製）
検出器：ＲＩ検出器（型式：ＲＩＤ−１０Ａ；島津製作所社製）
カラム：ＧＰＣカラム（型式：ＳＨＯＤＥＸ ＫＦ−８０１；昭和電工社製）及びＧＰＣカラム（型式：ＳＨＯＤＥＸ ＫＦ−８０２；昭和電工社製）の２本連結
移動相：ＴＨＦ（テトラヒドロフラン）
流量：１．０ｍＬ／ｍｉｎ
カラム温度：４０℃
サンプル濃度：０．０１ｇ／１ｍＬＴＨＦ
サンプル注入量：２０μＬ（ｉｎ ＴＨＦ）
(HPLC analysis conditions)
Apparatus: Shimadzu high-performance liquid chromatograph data processing software (model: LC solution ver. 1.0; manufactured by Shimadzu Corporation)
Pump (Model: LC-20AD; manufactured by Shimadzu Corporation)
Column oven (model: CTO-20A; manufactured by Shimadzu Corporation)
Autosampler (model: SIL-20A; manufactured by Shimadzu Corporation)
Detector: RI detector (model: RID-10A; manufactured by Shimadzu Corporation)
Column: GPC column (model: SHODEX KF-801; manufactured by Showa Denko KK) and GPC column (model: SHODEX KF-802; manufactured by Showa Denko KK), two-linked mobile phase: THF (tetrahydrofuran)
Flow rate: 1.0 mL / min
Column temperature: 40 ° C
Sample concentration: 0.01 g / 1 mL THF
Sample injection volume: 20 μL (in THF)
本発明で用いられる反応モノグリセライドを構成する脂肪酸としては、好ましくは食用可能な動植物油脂を起源とする炭素数６〜２４の直鎖の飽和脂肪酸（例えば、カプロン酸、カプリル酸、カプリン酸、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、アラキジン酸、ベヘン酸、リグノセリン酸）等が挙げられ、より好ましくはパルミチン酸、ステアリン酸若しくはベヘン酸又はこれらの混合物である。 The fatty acid constituting the reactive monoglyceride used in the present invention is preferably a linear saturated fatty acid having 6 to 24 carbon atoms derived from edible animal and vegetable oils and fats (for example, caproic acid, caprylic acid, capric acid, lauric acid). , Myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignoceric acid), etc., more preferably palmitic acid, stearic acid, behenic acid or a mixture thereof.
本発明で用いられる反応モノグリセライドの製法としては、例えば、（１）グリセリンと油脂とのエステル交換反応による製法、（２）グリセリンと脂肪酸とのエステル化反応による製法が挙げられる。これら製法の概略を、以下の（１）及び（２）にそれぞれ示す。 As a manufacturing method of the reaction monoglyceride used by this invention, the manufacturing method by (1) esterification reaction of glycerol and fats and oils and (2) the manufacturing method by esterification reaction of glycerol and a fatty acid are mentioned, for example. The outline of these production methods is shown in the following (1) and (2), respectively.
（１）エステル交換反応による反応モノグリセライドの製法
例えば、撹拌機、加熱用のジャケット、邪魔板等を備えた通常の反応容器に、グリセリン及び油脂を２：１のモル比で仕込み、通常触媒として、例えば水酸化ナトリウムを加えて撹拌混合し、窒素ガス雰囲気下、例えば１８０〜２６０℃、好ましくは２００〜２５０℃で、０．５〜１５時間、好ましくは１〜３時間加熱してエステル交換反応を行う。反応圧力条件は、常圧下又は減圧下が好ましい。得られた反応液は、グリセリン、モノグリセライド、ジグリセライド、トリグリセライド等を含む混合物である。
反応終了後、反応液中に残存する触媒を中和し、次に反応液を、好ましくは、減圧下で蒸留して残存するグリセリンを留去し、必要であれば脱塩、脱色、ろ過等の処理を行い、最終的に、全体に対してモノグリセライドを４０〜６０％、ジグリセライドを２５〜４５％含む反応モノグリセライドを得る。
(1) Production method of reaction monoglyceride by transesterification For example, in a normal reaction vessel equipped with a stirrer, a heating jacket, a baffle plate, etc., glycerin and fats and oils are charged in a molar ratio of 2: 1. For example, sodium hydroxide is added and stirred and mixed, and the ester exchange reaction is carried out by heating at a temperature of 180 to 260 ° C., preferably 200 to 250 ° C., for 0.5 to 15 hours, preferably 1 to 3 hours in a nitrogen gas atmosphere. Do. The reaction pressure condition is preferably normal pressure or reduced pressure. The obtained reaction liquid is a mixture containing glycerin, monoglyceride, diglyceride, triglyceride and the like.
After completion of the reaction, the catalyst remaining in the reaction solution is neutralized, and then the reaction solution is preferably distilled under reduced pressure to distill off the remaining glycerin. If necessary, desalting, decolorization, filtration, etc. Finally, a reaction monoglyceride containing 40-60% monoglyceride and 25-45% diglyceride is obtained.
（２）エステル化反応による反応モノグリセライドの製法
例えば、撹拌機、加熱用のジャケット、邪魔板等を備えた通常の反応容器にグリセリン及び脂肪酸を１：１のモル比で仕込み、必要に応じ酸又はアルカリを触媒として添加し、窒素又は二酸化炭素等の任意の不活性ガス雰囲気下で、例えば１８０〜２６０℃の範囲、好ましくは２００〜２５０℃で０．５〜５時間、好ましくは１〜３時間加熱してエステル化反応を行う。得られた反応液は、グリセリン、モノグリセライド、ジグリセライド、トリグリセライド等を含む混合物である。
反応終了後、反応液中に残存する触媒を中和し、次に反応液を、好ましくは、減圧下で蒸留して残存するグリセリンを留去し、必要であれば脱塩、脱色、ろ過等の処理を行い、最終的に、全体に対してモノグリセライドを４０〜６０％、ジグリセライドを２５〜４５％含む反応モノグリセライドを得る。
(2) Production method of reaction monoglyceride by esterification reaction For example, a normal reaction vessel equipped with a stirrer, a heating jacket, a baffle plate and the like is charged with glycerin and fatty acid at a molar ratio of 1: 1, and an acid or Alkali is added as a catalyst and under any inert gas atmosphere such as nitrogen or carbon dioxide, for example in the range of 180-260 ° C, preferably 200-250 ° C for 0.5-5 hours, preferably 1-3 hours. Esterification reaction is performed by heating. The obtained reaction liquid is a mixture containing glycerin, monoglyceride, diglyceride, triglyceride and the like.
After completion of the reaction, the catalyst remaining in the reaction solution is neutralized, and then the reaction solution is preferably distilled under reduced pressure to distill off the remaining glycerin. If necessary, desalting, decolorization, filtration, etc. Finally, a reaction monoglyceride containing 40-60% monoglyceride and 25-45% diglyceride is obtained.
ここで、本発明においては、構成脂肪酸の炭素数が異なる２種以上の反応モノグリセライドを併用してもよい。例えば、主構成脂肪酸の炭素数が１６〜１８の反応モノグリセライドと主構成脂肪酸の炭素数が２２の反応モノグリセライドを併用することができる。これにより、製造直後のソフトカプセル充填用液状組成物の２５℃における粘度が好ましい範囲（例えば、８〜２０パスカル秒）に調整される。ソフトカプセル充填用液状組成物の粘度がこのような範囲であると、食用油脂中での難油溶性成分の分散安定性が良好であり、ソフトカプセル剤を製造する工程およびソフトカプセル剤を製造後において難油溶性成分と食用油脂の分離が抑制されるため好ましい。また、該組成物をソフトカプセルに充填し、ソフトカプセル剤を製造する工程において不良品の発生が低減し、歩留りが改善されるため好ましい。 Here, in this invention, you may use together 2 or more types of reaction monoglycerides from which carbon number of a constituent fatty acid differs. For example, a reaction monoglyceride having 16 to 18 carbon atoms in the main constituent fatty acid and a reaction monoglyceride having 22 carbon atoms in the main constituent fatty acid can be used in combination. Thereby, the viscosity in 25 degreeC of the liquid composition for soft capsule filling immediately after manufacture is adjusted to the preferable range (for example, 8-20 pascal second). When the viscosity of the liquid composition for filling soft capsules is in such a range, the dispersion stability of the hardly oil-soluble component in the edible oil and fat is good, and the process for producing the soft capsule and the soft oil after production of the soft capsule are difficult. This is preferable because the separation of the soluble component and the edible fat is suppressed. In addition, the composition is preferably filled in soft capsules, and in the process of producing soft capsules, the occurrence of defective products is reduced and the yield is improved, which is preferable.
なお、上記粘度の測定は、１００ｍＬ容量トールビーカーにソフトカプセル充填用液状組成物を１００ｇ量り採り、該組成物の温度を恒温水槽中で２５℃に調整した後、回転粘度計（型式：ＴＶＢ−１０Ｍ；Ｍ４ローター装着；東機産業社製）を使用し、１分間に１２回転の速度での回転開始から１分が経過した時点の測定値を記録することにより実施できる。 The viscosity is measured by weighing 100 g of the soft capsule filling liquid composition into a 100 mL capacity tall beaker, adjusting the temperature of the composition to 25 ° C. in a constant temperature water bath, and then rotating the viscometer (model: TVB-10M). M4 rotor installed; manufactured by Toki Sangyo Co., Ltd.), and recording the measured value at the time when 1 minute has elapsed from the start of rotation at a speed of 12 revolutions per minute.
ここで、反応モノグリセライドについて「主構成脂肪酸」とは、反応モノグリセライドを構成する全脂肪酸１００質量％中、６０質量％以上、好ましくは７５質量％以上を占める脂肪酸をいう。従って、例えば主構成脂肪酸の炭素数１６〜１８の反応モノグリセライドは、該反応モノグリセライドを構成する全脂肪酸１００質量％中、炭素数１６〜１８の範囲に含まれる脂肪酸が６０質量％以上を占めるものを意味する。同様に、主構成脂肪酸の炭素数１８の反応モノグリセライドは、該反応モノグリセライドを構成する全脂肪酸１００質量％中、炭素数１８の脂肪酸（即ち、ステアリン酸等）が６０質量％以上を占めるものを意味する。また、後述の蒸留モノグリセライドについての「主構成脂肪酸」の定義もこれと同じである。 Here, with respect to the reactive monoglyceride, the “main constituent fatty acid” refers to a fatty acid occupying 60% by mass or more, preferably 75% by mass or more in 100% by mass of the total fatty acids constituting the reactive monoglyceride. Therefore, for example, the reaction monoglyceride having 16 to 18 carbon atoms of the main constituent fatty acid is one in which the fatty acid contained in the range of 16 to 18 carbon atoms occupies 60 mass% or more in 100 mass% of all fatty acids constituting the reaction monoglyceride. means. Similarly, the reaction monoglyceride having 18 carbon atoms of the main constituent fatty acid means that the fatty acid having 18 carbon atoms (that is, stearic acid, etc.) accounts for 60 mass% or more in 100 mass% of the total fatty acids constituting the reaction monoglyceride. To do. The definition of “main constituent fatty acid” for the distilled monoglyceride described later is the same as this.
反応モノグリセライドとしては、例えば、ポエムＰ−２００（製品名；主構成脂肪酸の炭素数１６〜１８；モノグリセライド含有量約５２％；理研ビタミン社製）、ポエムＶ−２００（製品名；主構成脂肪酸の炭素数１８；モノグリセライド含有量約５０％；理研ビタミン社製）及びポエムＢ−２００（製品名；主構成脂肪酸の炭素数２２；モノグリセライド含有量約４７％；理研ビタミン社製）等が商業的に製造及び販売されており、本発明ではこれらの市販品を反応モノグリセライドとして用いることができる。 Examples of the reactive monoglyceride include Poem P-200 (product name: 16 to 18 carbon atoms of main constituent fatty acid; monoglyceride content: about 52%; manufactured by Riken Vitamin Co., Ltd.), Poem V-200 (product name: main constituent fatty acid). Carbon number 18; monoglyceride content: about 50%; manufactured by Riken Vitamin Co., Ltd.) and Poem B-200 (product name: carbon number of main constituent fatty acid: 22; monoglyceride content: about 47%; manufactured by Riken Vitamin Co., Ltd.) Manufactured and sold, and in the present invention, these commercially available products can be used as the reaction monoglyceride.
本発明で用いられる主構成脂肪酸の炭素数が１６〜２０（好ましくは炭素数が１６〜１８）の蒸留モノグリセライドは、主構成脂肪酸の炭素数が１６〜２０（好ましくは炭素数が１６〜１８）の反応モノグリセライドを精製し、モノグリセライドの含有量を高めたものである。該蒸留モノグリセライド１００％中のモノグリセライドの含有量は、通常９０％以上である。 Distilled monoglycerides having 16 to 20 carbon atoms (preferably 16 to 18 carbon atoms) of the main constituent fatty acid used in the present invention have 16 to 20 carbon atoms (preferably 16 to 18 carbon atoms) of the main constituent fatty acid. The reaction monoglyceride was purified to increase the monoglyceride content. The content of monoglyceride in 100% of the distilled monoglyceride is usually 90% or more.
主構成脂肪酸の炭素数が１６〜２０の蒸留モノグリセライド１００％中のモノグリセライドの含有量は、上記分析条件にてＨＰＬＣを用いて分析することにより求められる。具体的には、蒸留モノグリセライドを上記ＨＰＬＣ分析条件で分析後、データ処理装置によりクロマトグラム上に記録された被検試料の各成分に対応するピークについて、積分計を用いてピーク面積を測定し、測定されたピーク面積に基づいて、面積百分率としてモノグリセライドの含有量を求めることができる。 The content of monoglyceride in 100% distilled monoglyceride having 16 to 20 carbon atoms of the main constituent fatty acid is determined by analyzing using HPLC under the above analysis conditions. Specifically, after analyzing the distilled monoglyceride under the above HPLC analysis conditions, the peak area corresponding to each component of the test sample recorded on the chromatogram by the data processor is measured using an integrator, Based on the measured peak area, the monoglyceride content can be determined as an area percentage.
主構成脂肪酸の炭素数が１６〜２０の蒸留モノグリセライドの製造方法としては、上記反応モノグリセライドの製造方法に従い、主構成脂肪酸の炭素数が１６〜２０の反応モノグリセライドを製造し、該反応モノグリセライドを精製することにより製造することができる。精製方法としては、例えば流下薄膜式分子蒸留装置又は遠心式分子蒸留装置等を用いて真空蒸留する方法が挙げられる。これらの方法を用いて精製することにより、モノグリセライドを全体の約９０％以上含む蒸留モノグリセライドであって、主構成脂肪酸の炭素数が１６〜２０のものを得ることができる。該蒸留モノグリセライド中のモノグリセライド含有量の上限は、通常９９％程度である。 As a method for producing a distilled monoglyceride having 16 to 20 carbon atoms in the main constituent fatty acid, a reaction monoglyceride having 16 to 20 carbon atoms in the main constituent fatty acid is produced in accordance with the method for producing a reaction monoglyceride, and the reaction monoglyceride is purified. Can be manufactured. Examples of the purification method include a vacuum distillation method using a falling film molecular distillation apparatus or a centrifugal molecular distillation apparatus. By refine | purifying using these methods, it is the distillation monoglyceride which contains about 90% or more of the whole monoglyceride, Comprising: The carbon number of the main constituent fatty acid of 16-20 can be obtained. The upper limit of the monoglyceride content in the distilled monoglyceride is usually about 99%.
主構成脂肪酸の炭素数が１６〜２０の蒸留モノグリセライドとしては、例えば、エマルジーＰ−１００（製品名；主構成脂肪酸の炭素数１６〜１８；モノグリセライド含有量約９８％；理研ビタミン社製）、ポエムＳ−１００（製品名；主構成脂肪酸の炭素数１８；モノグリセライド含有量約９８％；理研ビタミン社製）等が商業的に製造及び販売されており、本発明ではこれらを用いることができる。 Examples of the distilled monoglyceride having 16 to 20 carbon atoms of the main constituent fatty acid include Emulsy P-100 (product name; 16 to 18 carbon atoms of the main constituent fatty acid; monoglyceride content: about 98%; manufactured by Riken Vitamin Co., Ltd.), Poem S-100 (product name; carbon number of main constituent fatty acid: 18; monoglyceride content: about 98%; manufactured by Riken Vitamin Co., Ltd.) and the like are commercially produced and sold, and these can be used in the present invention.
本発明で用いられる主構成脂肪酸の炭素数が２２の蒸留モノグリセライドは、主構成脂肪酸の炭素数が２２の反応モノグリセライドを精製し、モノグリセライドの含有量を高めたものである。該蒸留モノグリセライド１００％中のモノグリセライドの含有量は、通常９０％以上である。 Distilled monoglyceride having 22 carbon atoms in the main constituent fatty acid used in the present invention is obtained by purifying a reaction monoglyceride having 22 carbon atoms in the main constituent fatty acid to increase the monoglyceride content. The content of monoglyceride in 100% of the distilled monoglyceride is usually 90% or more.
主構成脂肪酸の炭素数が２２の蒸留モノグリセライド１００％中のモノグリセライドの含有量は、上記分析条件にてＨＰＬＣを用いて分析することにより求められる。具体的には、蒸留モノグリセライドを上記ＨＰＬＣ分析条件で分析後、データ処理装置によりクロマトグラム上に記録された被検試料の各成分に対応するピークについて、積分計を用いてピーク面積を測定し、測定されたピーク面積に基づいて、面積百分率としてモノグリセライドの含有量を求めることができる。 The content of monoglyceride in 100% distilled monoglyceride having 22 carbon atoms of the main constituent fatty acid is determined by analyzing using HPLC under the above analysis conditions. Specifically, after analyzing the distilled monoglyceride under the above HPLC analysis conditions, the peak area corresponding to each component of the test sample recorded on the chromatogram by the data processor is measured using an integrator, Based on the measured peak area, the monoglyceride content can be determined as an area percentage.
主構成脂肪酸の炭素数が２２の蒸留モノグリセライドの製造方法としては、上記反応モノグリセライドの製造方法に従い、主構成脂肪酸の炭素数が２２の反応モノグリセライドを製造し、該反応モノグリセライドを精製することにより製造することができる。精製方法としては、例えば流下薄膜式分子蒸留装置又は遠心式分子蒸留装置等を用いて真空蒸留する方法が挙げられる。これらの方法を用いて精製することにより、モノグリセライドを全体の約９０％以上含む蒸留モノグリセライドであって、主構成脂肪酸の炭素数が２２のものを得ることができる。該蒸留モノグリセライド中のモノグリセライド含有量の上限は、通常９９％程度である。 As a method for producing a distilled monoglyceride having 22 carbon atoms in the main constituent fatty acid, a reaction monoglyceride having 22 carbon atoms in the main constituent fatty acid is produced by purifying the reaction monoglyceride in accordance with the production method of the reaction monoglyceride. be able to. Examples of the purification method include a vacuum distillation method using a falling film molecular distillation apparatus or a centrifugal molecular distillation apparatus. By refine | purifying using these methods, it is the distillation monoglyceride which contains about 90% or more of the whole monoglyceride, Comprising: The carbon number of the main constituent fatty acid 22 can be obtained. The upper limit of the monoglyceride content in the distilled monoglyceride is usually about 99%.
主構成脂肪酸の炭素数が２２の蒸留モノグリセライドとしては、例えば、ポエムＢ−１００（製品名；主構成脂肪酸の炭素数２２；モノグリセライド含有量約９６％；理研ビタミン社製）等が商業的に製造及び販売されており、本発明ではこれを用いることができる。 For example, Poem B-100 (product name; carbon number of main constituent fatty acid: 22; monoglyceride content: about 96%; manufactured by Riken Vitamin Co., Ltd.) is commercially produced as a distilled monoglyceride having 22 main constituent fatty acids. Which can be used in the present invention.
本発明のソフトカプセル充填用液状組成物は、本発明の効果を奏する限り、必要に応じて上記食用油脂、難油溶性成分、反応モノグリセライド、主構成脂肪酸の炭素数が１６〜２０の蒸留モノグリセライド及び主構成脂肪酸の炭素数が２２の蒸留モノグリセライド以外のその他の成分を含んでもよい。その他の成分としては、モノエステル体含有量が５０％以上のジグリセリン脂肪酸エステル、酸化防止剤（例えば、抽出トコフェロール、アスコルビン酸パルミチン酸エステル）等が挙げられる。その他の成分は１種又は２種以上を組み合わせて用いることができる。 As long as the liquid composition for filling soft capsules of the present invention exerts the effects of the present invention, the edible oil and fat, the hardly oil-soluble component, the reactive monoglyceride, the distilled monoglyceride having 16 to 20 carbon atoms of the main constituent fatty acid, and the main component as necessary. Other components other than the distilled monoglyceride having 22 carbon atoms in the constituent fatty acid may be included. Examples of other components include diglycerin fatty acid esters having a monoester content of 50% or more, antioxidants (for example, extracted tocopherol, ascorbyl palmitate), and the like. Other components can be used alone or in combination of two or more.
本発明のソフトカプセル充填用液状組成物は、上記食用油脂、難油溶性成分、反応モノグリセライド、主構成脂肪酸の炭素数が１６〜２０の蒸留モノグリセライド、主構成脂肪酸の炭素数が２２の蒸留モノグリセライド及び必要に応じてモノエステル体含有量が５０％以上のジグリセリン脂肪酸エステルを混合及び撹拌しながら、これらの成分を均一に分散させることにより製造される。具体的には、例えば、食用油脂、反応モノグリセライド、主構成脂肪酸の炭素数が１６〜２０の蒸留モノグリセライド、主構成脂肪酸の炭素数が２２の蒸留モノグリセライド及び必要に応じてモノエステル体含有量が５０％以上のジグリセリン脂肪酸エステルを、例えば、６０〜９０℃、好ましくは７０〜８０℃に加熱して均一に混合及び撹拌して溶解液を調製した後、該溶解液を例えば４０〜６０℃に冷却し、更に難油溶性成分を加えて混合及び撹拌し、該難油溶性成分を均一に分散して製造される。なお、反応モノグリセライド、主構成脂肪酸の炭素数が１６〜２０の蒸留モノグリセライド、主構成脂肪酸の炭素数が２２の蒸留モノグリセライド及びモノエステル体含有量が５０％以上のジグリセリン脂肪酸エステルは、これらを予め混合し、加熱して溶融させたものを使用することができる。混合及び撹拌するための装置に特に制限はないが、例えば、バイオミキサー、ホモジェッター等の高速撹拌機又は高速粉砕機を用いることができる。 The liquid composition for filling soft capsules of the present invention includes the above edible oil and fat, a hardly oil-soluble component, a reactive monoglyceride, a distilled monoglyceride having 16 to 20 carbon atoms of the main constituent fatty acid, a distilled monoglyceride having 22 carbon atoms of the main constituent fatty acid, and necessary. Accordingly, the diglycerin fatty acid ester having a monoester content of 50% or more is mixed and stirred to uniformly disperse these components. Specifically, for example, edible fats and oils, reaction monoglyceride, distilled monoglyceride having 16 to 20 carbon atoms in the main constituent fatty acid, distilled monoglyceride having 22 carbon atoms in the main constituent fatty acid, and optionally a monoester content of 50. % Of diglycerin fatty acid ester is heated to, for example, 60 to 90 ° C., preferably 70 to 80 ° C., and uniformly mixed and stirred to prepare a solution, and then the solution is heated to, for example, 40 to 60 ° C. It is cooled, and further, a hardly oil-soluble component is added, mixed and stirred, and the hardly oil-soluble component is uniformly dispersed. The reaction monoglyceride, the distilled monoglyceride having 16 to 20 carbon atoms of the main constituent fatty acid, the distilled monoglyceride having 22 carbon atoms of the main constituent fatty acid, and the diglycerin fatty acid ester having a monoester content of 50% or more are pre- What was mixed and heated and melted can be used. Although there is no restriction | limiting in particular in the apparatus for mixing and stirring, For example, high-speed stirrers, such as a biomixer and a homojetter, or a high-speed grinder can be used.
本発明のソフトカプセル充填用液状組成物１００質量％中の食用油脂の含有量は特に限定されないが、例えば、通常２０〜９５質量％、好ましくは２５〜９０質量％、より好ましくは３０〜８０質量％である。本発明において食用油脂の含有量が上記範囲であれば、難油溶性成分を食用油脂中に十分に分散させることができるとともに、食用油脂中における難油溶性成分の分散安定性が良好である。 The content of the edible fat / oil in 100% by mass of the liquid composition for filling soft capsules of the present invention is not particularly limited, but is usually 20 to 95% by mass, preferably 25 to 90% by mass, and more preferably 30 to 80% by mass. It is. In the present invention, if the content of the edible oil / fat is in the above range, the hardly oil-soluble component can be sufficiently dispersed in the edible oil / fat, and the dispersion stability of the hardly oil-soluble component in the edible oil / fat is good.
本発明のソフトカプセル充填用液状組成物１００質量％中の難油溶性成分の含有量は、特に限定されないが、例えば、通常１〜７０質量％、好ましくは３〜６０質量％、より好ましくは１０〜５０質量％である。本発明において難油溶性成分の含有量が上記範囲であれば、難油溶性成分を食用油脂中に十分に分散させることができる。また、食用油脂中での難油溶性成分の分散安定性が良好であるため、ソフトカプセル剤中で難油溶性成分の分離が生じない。 The content of the hardly oil-soluble component in 100% by mass of the liquid composition for filling soft capsules of the present invention is not particularly limited, but is usually 1 to 70% by mass, preferably 3 to 60% by mass, more preferably 10 to 10% by mass. 50% by mass. If content of a hardly oil-soluble component is the said range in this invention, a hardly oil-soluble component can fully be disperse | distributed in edible fats and oils. Moreover, since the dispersion stability of the hardly oil-soluble component in the edible fat is good, the hardly oil-soluble component is not separated in the soft capsule.
本発明のソフトカプセル充填用液状組成物１００質量％中の反応モノグリセライドの含有量は、特に限定されないが、例えば、通常０．５〜１５質量％、好ましくは０．５〜１０質量％、より好ましくは１〜８質量％である。本発明において該反応モノグリセライドの含有量が上記範囲であれば、食用油脂中での難油溶性成分の分散安定性が良好であるため、ソフトカプセル剤中で難油溶性成分の分離が生じない。また、ソフトカプセル充填用液状組成物の保存中における硬度の上昇が抑制され、該組成物をソフトカプセルに充填する工程が容易になる。 The content of the reactive monoglyceride in 100% by mass of the liquid composition for filling soft capsules of the present invention is not particularly limited, but is usually 0.5 to 15% by mass, preferably 0.5 to 10% by mass, and more preferably. 1 to 8% by mass. In the present invention, if the content of the reactive monoglyceride is in the above range, the dispersion stability of the hardly oil-soluble component in the edible fat is good, so that the hardly oil-soluble component is not separated in the soft capsule. In addition, an increase in hardness during storage of the liquid composition for filling soft capsules is suppressed, and the process of filling the soft capsules with the composition becomes easy.
本発明のソフトカプセル充填用液状組成物１００質量％中の主構成脂肪酸の炭素数が１６〜２０の蒸留モノグリセライドの含有量は、特に限定されないが、例えば、通常０．５〜１５質量％、好ましくは０．５〜１０質量％、より好ましくは１〜８質量％である。本発明において該蒸留モノグリセライドの含有量が上記範囲であれば、食用油脂中での難油溶性成分の分散安定性が良好であるため、ソフトカプセル剤中で難油溶性成分の分離が生じない。また、ソフトカプセル充填用液状組成物の保存中における硬度の上昇が抑制され、該組成物をソフトカプセルに充填する工程が容易になる。 The content of the distilled monoglyceride having 16 to 20 carbon atoms of the main constituent fatty acid in 100% by mass of the liquid composition for filling soft capsules of the present invention is not particularly limited, but is usually 0.5 to 15% by mass, preferably, for example. It is 0.5-10 mass%, More preferably, it is 1-8 mass%. In the present invention, when the content of the distilled monoglyceride is in the above range, the dispersion stability of the hardly oil-soluble component in the edible fat is good, and therefore the hardly oil-soluble component is not separated in the soft capsule. In addition, an increase in hardness during storage of the liquid composition for filling soft capsules is suppressed, and the process of filling the soft capsules with the composition becomes easy.
本発明のソフトカプセル充填用液状組成物１００質量％中の主構成脂肪酸の炭素数が２２の蒸留モノグリセライドの含有量は、特に限定されないが、例えば、通常０．５〜１５質量％、好ましくは０．５〜１０質量％、より好ましくは１〜８質量％である。本発明において該蒸留モノグリセライドの含有量が上記範囲であれば、食用油脂中での難油溶性成分の分散安定性が良好であるため、ソフトカプセル剤中で難油溶性成分の分離が生じない。また、ソフトカプセル充填用液状組成物の保存中における硬度の上昇が抑制され、該組成物をソフトカプセルに充填する工程が容易になる。 The content of the distilled monoglyceride having 22 carbon atoms of the main constituent fatty acid in 100% by mass of the liquid composition for filling soft capsules of the present invention is not particularly limited, but is usually 0.5 to 15% by mass, preferably 0.00. It is 5-10 mass%, More preferably, it is 1-8 mass%. In the present invention, when the content of the distilled monoglyceride is in the above range, the dispersion stability of the hardly oil-soluble component in the edible fat is good, and therefore the hardly oil-soluble component is not separated in the soft capsule. In addition, an increase in hardness during storage of the liquid composition for filling soft capsules is suppressed, and the process of filling the soft capsules with the composition becomes easy.
また、本発明のソフトカプセル充填用液状組成物にモノエステル体含有量５０％以上のジグリセリン脂肪酸エステルを使用する場合、該組成物１００質量％中のモノエステル体含有量５０％以上のジグリセリン脂肪酸エステルの含有量は、特に限定されないが、例えば、通常０．０５〜１．５質量％、好ましくは、０．０５〜１質量％、より好ましくは０．１〜１質量％である。本発明において該ジグリセリン脂肪酸エステルの含有量が上記範囲であれば、つまり、生体内（例えば、胃液中）において難油溶性成分が十分に分散するため、ソフトカプセル剤の摂取により難油溶性成分の効果が十分に発揮されることが期待できる。 When a diglycerin fatty acid ester having a monoester content of 50% or more is used in the liquid composition for filling soft capsules of the present invention, the diglycerin fatty acid having a monoester content of 50% or more in 100% by mass of the composition is used. Although content of ester is not specifically limited, For example, it is 0.05-1.5 mass% normally, Preferably, it is 0.05-1 mass%, More preferably, it is 0.1-1 mass%. In the present invention, if the content of the diglycerin fatty acid ester is in the above range, that is, the poorly oil-soluble component is sufficiently dispersed in the living body (for example, in the gastric juice), It can be expected that the effect is fully exhibited.
このようにして得られるソフトカプセル充填用液状組成物を、常法に従い、ゼラチンを主成分とする皮膜で包み込むことによりソフトカプセル剤を製造することができる。具体的には、例えば、２枚のゼラチンシートの間に内容物としてソフトカプセル充填用液状組成物を一定量注入して打ち抜く方法によりソフトカプセル剤を製造することができる。 Soft capsules can be produced by wrapping the thus obtained liquid composition for filling soft capsules with a film mainly composed of gelatin according to a conventional method. Specifically, for example, a soft capsule can be produced by a method of injecting a predetermined amount of a liquid composition for filling a soft capsule between two gelatin sheets and punching it out.
以下に本発明を実施例に基づいてより具体的に説明するが、本発明はこれらに限定されるものではない。 Hereinafter, the present invention will be described more specifically based on examples, but the present invention is not limited thereto.
［ソフトカプセル充填用液状組成物の作製］
（１）ソフトカプセル充填用液状組成物作製のための原材料
１）菜種サラダ油（Ｊ−オイルミルズ社製）
２）コーンスターチ（三和澱粉工業社製）
３）リボフラビン（理研ビタミン社製）
４）反応モノグリセライド（商品名：ポエムＰ−２００；モノグリセライド含有量約５２％；理研ビタミン社製）
５）反応モノグリセライド（商品名：ポエムＶ−２００；モノグリセライド含有量約５０％；理研ビタミン社製）
６）反応モノグリセライド（商品名：ポエムＢ−２００；モノグリセライド含有量約４７％；理研ビタミン社製）
７）主構成脂肪酸の炭素数が１６〜１８の蒸留モノグリセライド（商品名：エマルジーＰ−１００；モノグリセライド含有量約９８％；理研ビタミン社製）
８）主構成脂肪酸の炭素数が１８の蒸留モノグリセライド（商品名：ポエムＳ−１００；モノグリセライド含有量約９８％；理研ビタミン社製）
９）主構成脂肪酸の炭素数が２２の蒸留モノグリセライド（商品名：ポエムＢ−１００；モノグリセライド含有量約９６％；理研ビタミン社製）
１０）ジグリセリン脂肪酸エステル（商品名：ポエムＤＭ−１００；モノエステル体含有量約８１％；理研ビタミン社製）
１１）トリグリセリン脂肪酸エステル（商品名：ポエムＨＢ；理研ビタミン社製）
１２）テトラグリセリン脂肪酸エステル（商品名：ポエムＪ−４６Ｂ；理研ビタミン社製）
[Preparation of liquid composition for soft capsule filling]
(1) Raw materials for preparation of liquid composition for soft capsule filling 1) Rapeseed salad oil (manufactured by J-Oil Mills)
2) Corn starch (manufactured by Sanwa Starch Kogyo Co., Ltd.)
3) Riboflavin (manufactured by Riken Vitamin)
4) Reactive monoglyceride (trade name: Poem P-200; monoglyceride content: about 52%; manufactured by Riken Vitamin Co., Ltd.)
5) Reactive monoglyceride (trade name: Poem V-200; monoglyceride content: about 50%; manufactured by Riken Vitamin Co., Ltd.)
6) Reactive monoglyceride (trade name: Poem B-200; monoglyceride content: about 47%; manufactured by Riken Vitamin Co., Ltd.)
7) Distilled monoglyceride having 16 to 18 carbon atoms of main constituent fatty acid (trade name: Emulsy P-100; monoglyceride content: about 98%; manufactured by Riken Vitamin Co., Ltd.)
8) Distilled monoglyceride whose main constituent fatty acid has 18 carbon atoms (trade name: Poem S-100; monoglyceride content: about 98%; manufactured by Riken Vitamin Co., Ltd.)
9) Distilled monoglyceride whose main constituent fatty acid has 22 carbon atoms (trade name: Poem B-100; monoglyceride content: about 96%; manufactured by Riken Vitamin Co., Ltd.)
10) Diglycerin fatty acid ester (trade name: Poem DM-100; monoester content: about 81%; manufactured by Riken Vitamin Co., Ltd.)
11) Triglycerin fatty acid ester (trade name: Poem HB; manufactured by Riken Vitamin Co., Ltd.)
12) Tetraglycerin fatty acid ester (trade name: Poem J-46B; manufactured by Riken Vitamin Co., Ltd.)
（２）原材料の配合組成
ソフトカプセル充填用液状組成物（実施品１〜６及び比較品１〜７）の作製に使用した原材料の配合組成を表１及び表２に示した。この内、実施品１〜６は本発明に係る実施例であり、比較品１〜７はそれらに対する比較例である。
(2) Blending composition of raw materials Tables 1 and 2 show blending compositions of raw materials used for the preparation of liquid compositions for filling soft capsules (Examples 1 to 6 and Comparative products 1 to 7). Of these, Examples 1 to 6 are examples according to the present invention, and Comparative Examples 1 to 7 are comparative examples for them.
（３）ソフトカプセル充填用液状組成物の作製
表１及び表２に示した配合組成に基づいてソフトカプセル充填用液状組成物を作製した。即ち、反応モノグリセライド、主構成脂肪酸の炭素数が１６〜２０の蒸留モノグリセライド、主構成脂肪酸の炭素数が２２の蒸留モノグリセライド、ジグリセリン脂肪酸エステル、トリグリセリン脂肪酸エステル、テトラグリセリン脂肪酸エステルを菜種サラダ油に加え、これを８０℃に加熱して撹拌し、これらの食品用乳化剤を該サラダ油中に溶解させた。得られた溶解液を水浴中で５０℃まで冷却し、これを室温下でミキサー（型式：ウルトラタラックスＴ−２５ベーシック；ＩＫＡジャパン社製）を使用して８０００ｒｐｍで撹拌しながらコーンスターチ及びリボフラビンを加えて、さらに８０００ｒｐｍで１０分間撹拌し、コーンスターチ及びリボフラビンがサラダ油中に分散した分散液を得た。このとき、溶解液ないし分散液の温度が４０〜５０℃になるように温水または冷水を使用して適宜温度調整した。得られた分散液を真空脱泡処理した後、水浴中で２５℃まで冷却し、ソフトカプセル充填用液状組成物約１５０ｇ（実施品１〜６及び比較品１〜７）を得た。
(3) Production of liquid composition for filling soft capsules A liquid composition for filling soft capsules was produced based on the composition shown in Tables 1 and 2. That is, a reaction monoglyceride, a distilled monoglyceride having 16 to 20 carbon atoms in the main constituent fatty acid, a distilled monoglyceride having 22 carbon atoms in the main constituent fatty acid, a diglycerin fatty acid ester, a triglycerin fatty acid ester, and a tetraglycerin fatty acid ester are added to the rapeseed salad oil. This was heated to 80 ° C. and stirred to dissolve these food emulsifiers in the salad oil. The obtained lysate was cooled to 50 ° C. in a water bath, and corn starch and riboflavin were stirred at 8000 rpm using a mixer (model: Ultra Turrax T-25 Basic; manufactured by IKA Japan) at room temperature. In addition, the mixture was further stirred at 8000 rpm for 10 minutes to obtain a dispersion in which corn starch and riboflavin were dispersed in salad oil. At this time, the temperature of the solution or dispersion was appropriately adjusted using hot water or cold water so that the temperature of the solution or dispersion was 40 to 50 ° C. The obtained dispersion was vacuum degassed and then cooled to 25 ° C. in a water bath to obtain about 150 g of a liquid composition for filling soft capsules (Examples 1 to 6 and Comparative products 1 to 7).
（４）ソフトカプセル充填用液状組成物の評価
上述した方法により作製したソフトカプセル充填用液状組成物（実施品１〜６及び比較品１〜７）の各々について下記の評価試験を実施した。結果を表３に示した。
(4) Evaluation of liquid composition for filling soft capsules The following evaluation tests were carried out for each of the liquid compositions for filling soft capsules (Examples 1 to 6 and Comparative products 1 to 7) prepared by the above-described method. The results are shown in Table 3.
[難油溶性成分の分離の評価]
ソフトカプセル充填用液状組成物（実施品１〜６及び比較品１〜７）の各々を遠沈管（容量５０ｍＬ；プラスチック製）に４０ｇ入れ、これを遠心機（型式：ＳＬ−ＩＶ；佐久間製作所社製）を用いて回転数３０００ｒｐｍで１５分間遠心した。その後、遠心分離機から遠沈管を取り出し、遠沈管の試料について、難油溶性成分（コーンスターチ及びリボフラビン）の分離の有無を目視により観察した。
[Evaluation of separation of hardly oil-soluble components]
40 g of each of the liquid compositions for filling soft capsules (implemented products 1 to 6 and comparative products 1 to 7) is placed in a centrifuge tube (capacity 50 mL; made of plastic), and this is centrifuged (model: SL-IV; manufactured by Sakuma Seisakusho). ), And centrifuged at 3000 rpm for 15 minutes. Thereafter, the centrifuge tube was taken out from the centrifuge, and the presence or absence of separation of the hardly oil-soluble components (corn starch and riboflavin) was visually observed in the centrifuge tube sample.
[硬度の評価]
ソフトカプセル充填用液状組成物（実施品１〜６及び比較品１〜７）の各々をプラスチック製の円錐台形状の容器（容量９０ｍＬ；内径：上部６５ｍｍ、底部４５ｍｍ）に５０ｇ充填し、２５℃で２４時間保存した後、硬度を測定した。硬度の測定では、テクスチャアナライザ（型式：ＥＺ−Ｔｅｓｔ；φ１４円柱型治具装着；進入速度１２０ｍｍ／ｍｉｎ；島津製作所社製）を使用し、円柱型治具を組成物の表面からその内部に１０ｍｍ進入させるまでの間に測定される最大応力（Ｎ）を硬度とした。
[Evaluation of hardness]
50 g of each of the soft capsule filling liquid compositions (Examples 1 to 6 and Comparative products 1 to 7) is filled into a plastic truncated cone container (capacity 90 mL; inner diameter: upper part 65 mm, bottom part 45 mm) at 25 ° C. After storage for 24 hours, the hardness was measured. For the measurement of hardness, a texture analyzer (model: EZ-Test; φ14 cylindrical jig mounted; entry speed 120 mm / min; manufactured by Shimadzu Corporation) was used, and the cylindrical jig was placed 10 mm from the surface of the composition to the inside. The maximum stress (N) measured before entering was determined as the hardness.
表３の結果から明らかなように、実施品１〜６のいずれも、難油溶性成分の分離が生じておらず、また、硬度が１．００Ｎ未満に抑制されていた。一方、比較品１〜４及び比較品６〜７では、難油溶性成分の分離が生じていた。また、比較品５では、難油溶性成分の分離は生じなかったが、その硬度は２．００Ｎにまで上昇していた。即ち、比較品１〜７は、いずれもソフトカプセル剤への使用に適さないものであった。 As is clear from the results in Table 3, none of the practical products 1 to 6 caused the separation of the hardly oil-soluble component, and the hardness was suppressed to less than 1.00 N. On the other hand, in the comparative products 1 to 4 and the comparative products 6 to 7, separation of the hardly oil-soluble component occurred. Further, in Comparative product 5, the hardly oil-soluble component was not separated, but the hardness increased to 2.00 N. That is, Comparative products 1 to 7 were all unsuitable for use in soft capsules.
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