JP6312605B2 - Stacked integrated component media insert for ophthalmic devices - Google Patents

Description

  The present invention relates to a method of forming a laminated integrated component media insert for an ophthalmic lens and a laminated integrated component media insert for an ophthalmic lens.

  Traditionally, ophthalmic devices such as contact lenses, intraocular lenses, or punctal plugs have included biocompatible devices having corrective, cosmetic, or therapeutic properties. For example, a contact lens can provide one or more of a vision correction function, a cosmetic effect, and a therapeutic effect. Each function is given by the physical properties of the lens. According to the design in which the refractive property is incorporated into the lens, a vision correction function can be provided. A cosmetic effect can be given by incorporating a pigment into the lens. Incorporating an active agent into the lens can provide a therapeutic effect. These physical properties are realized without the lens being energized.

  More recently, it has been theorized that active elements can be incorporated into contact lenses. Some elements include semiconductor devices. There are several examples showing semiconductor devices embedded in contact lenses that are placed in the animal's eyes. However, such devices lack a permanent energy application mechanism. Although the wire can be routed from the lens to the battery to power such a semiconductor device, it has been theorized that this device can be powered wirelessly. The mechanism for wireless power is not available.

  Thus, energized to a suitable degree to provide one or more functions to the ophthalmic lens and a controlled change in the optical characteristics of the ophthalmic lens or other biomedical device, It would be desirable to have additional methods and devices that contribute to the formation of ophthalmic lenses.

  According to an aspect of the present invention, a method of forming a laminated integrated component media insert for an ophthalmic lens is provided. The method includes the steps of forming a functional base material layer, assembling the base material layer, forming an electrical interconnect between the base material layers, and in a molded ophthalmic lens body. Encapsulating the laminating mechanism with a bonding material.

  The base material layer may be assembled into a circular annular shape or one shape of a part of the annular shape.

  The laminated functional layer can be adhered to the insulating layer to form a lamination mechanism.

  The second stacked integrated component layer may be molded into at least a portion of a circular ring having a smaller outer radius than the first layer.

  One or more layers may comprise a metallic feature surface.

  The solder film may be placed on the surface of one or more layers with metallic characteristics.

  The method may include placing a battery on the stacked integrated component media insert, the battery being rechargeable via one or more of radio frequency and magnetic inductance.

  The method may include placing a thin film battery on the stacked integrated component media insert and changing the surface of the battery to define the appearance of the battery.

  The substrate layer may be flexible.

  According to a further aspect, a method is provided that includes forming a stacked integrated component media insert and coupling the media insert into an ophthalmic lens.

  According to a further aspect, a stacked integrated component layer insert is provided. The insert includes a functional substrate layer that is assembled to form an electrical interconnect between the substrate layers and that provides a laminating mechanism to provide a laminating mechanism. The mechanism is encapsulated with a bonding material within the body of the molded ophthalmic lens.

  The base material layer may be assembled into a circular annular shape or one shape of a part of the annular shape.

  The laminated functional layer can be adhered to the insulating layer to form a lamination mechanism.

  The laminated integrated component layer insert may include a second laminated integrated component layer that is molded into at least a portion of a circular ring having a smaller outer radius than the first layer.

  One or more layers may comprise a metallic feature surface.

  The laminated integrated component layer insert may include a solder film placed on the surface of one or more layers with metallic features.

  The stacked integrated component layer insert may include a battery configured to be rechargeable via one or more of radio frequency and magnetic inductance.

  The laminated integrated component layer insert may include a thin film battery, and the surface of the thin film battery is configured to define a predetermined appearance.

  The substrate layer may be flexible.

  According to a further aspect, an ophthalmic lens is provided that includes a laminated integrated component layer insert coupled therein.

  Media inserts that are energized and that can be incorporated into ophthalmic devices, such as contact lenses or punctal plugs, are described herein. In addition, a method and apparatus for forming an ophthalmic lens having an energized media insert is shown. In some exemplary embodiments, the energized media can provide power to components that can draw current. The components can include, for example, one or more of variable optical lens elements, semiconductor devices, and active or passive electrical devices. Some examples may also include a cast molded silicone hydrogel contact lens with a rigid or moldable, energized insert housed in a biocompatible ophthalmic lens.

  Described herein are an ophthalmic lens having an energized media portion, an apparatus for forming an ophthalmic lens having an energized media portion, and a method for making the same. An energy source may be deposited on the media insert and the insert may be placed proximal to one or both of the first mold portion and the second mold portion. A reactive monomer mixture is placed between the first mold part and the second mold part. Positioning the first mold part proximate to the second mold part results in the formation of a lens cavity with at least some of the energized media insert and reactive monomer mixture therein, the reactive monomer. An ophthalmic lens is formed by exposing the mixture to actinic radiation. The lens is formed through control of actinic radiation to which the reactive monomer mixture is exposed.

1 illustrates a mold assembly apparatus according to an embodiment of the present invention. Fig. 3 illustrates various media inserts that can be placed in an ophthalmic lens according to embodiments of the present invention. Fig. 3 illustrates various media inserts that can be placed in an ophthalmic lens according to embodiments of the present invention. Fig. 3 illustrates various media inserts that can be placed in an ophthalmic lens according to embodiments of the present invention. Fig. 3 illustrates various media inserts that can be placed in an ophthalmic lens according to embodiments of the present invention. 1 illustrates an apparatus for placing an energy source within an ophthalmic lens mold part. Fig. 4 illustrates a method step according to an embodiment of the invention. Fig. 4 illustrates method steps according to some further aspects of the invention. Fig. 4 illustrates a processor that may be used to perform a method according to an embodiment of the invention. 2 illustrates a representative media insert depiction. 2 illustrates a cross-sectional view of a representative media insert. FIG. 6 illustrates a cross-sectional view of a stacked integrated component device with a stacked integrated component media insert energized according to an embodiment of the present invention. Figure 3 illustrates a stacked integrated component media insert in a representative ophthalmic lens.

  The present invention relates to a media insert and a method for forming a media insert for an ophthalmic lens. In addition, the media insert may be incorporated into an ophthalmic lens.

  The energized lens 100 includes an embedded media insert and an energy source, eg, an electrochemical cell or battery as an energy storage means, and optionally an energy source from the environment in which the ophthalmic lens is placed. It may be formed as having encapsulating and separating material.

  In some exemplary embodiments, the media insert also includes a pattern of circuits, components, and energy sources. Media inserts that place patterns of circuitry, components, and energy sources may be included around the periphery of the optical zone through which the lens wearer will see, but as an alternative, contact Patterns of circuits, components, and energy sources that are small enough not to adversely affect the lens wearer's field of view are included, so that the media insert can position them within or outside the optical zone.

  Generally, the media insert is integrated into the interior of the ophthalmic lens via automation, which places the energy source in the desired location relative to the mold part used to mold the lens.

  In some exemplary embodiments, the energy source is placed in electrical communication with components included in the ophthalmic lens that can be activated by command and draw current from the energy source. Components include, for example, semiconductor devices, active or passive electrical devices, or electrically activated equipment (eg, including microelectromechanical systems (MEMS), nanoelectromechanical systems (NEMS), or micromachines). May be included. After placement of the energy source and components, the reaction mixture can be shaped by the mold part and polymerized to form an ophthalmic lens.

  The following sections provide a detailed description of each embodiment of the invention. It is understood that the descriptions of the preferred and alternative embodiments are merely exemplary embodiments, and that variations, modifications, and changes may be apparent to those skilled in the art. Thus, it should be understood that these exemplary embodiments do not limit the scope of the underlying invention.

Glossary In this description and claims directed to the present invention, various terms may be used to which the following definitions apply.
A component, as used herein, refers to a device that can draw current from an energy source to cause one or more changes in logical or physical state.

  Energized, as used herein, refers to a state that can supply current or have electrical energy stored therein.

  Energy, as used herein, refers to the ability of a physical system to do work. Many of the cases used in the present invention may be related to the ability to perform electrical actions when working.

  An energy source, as used herein, refers to a device that can provide energy or leave a biomedical device energized.

  An energy harvester, as used herein, refers to a device that can extract energy from the environment and convert it to electrical energy.

  A lens refers to any ophthalmic device that is placed in or on the surface of the eye. These devices may provide optical correction or may be cosmetic. For example, the term lens refers to contact lenses, intraocular lenses, overlay lenses, eyeball inserts, optical inserts, or cosmetic vision that is corrected or altered thereby, or the physiological properties of the eye do not interfere with vision. It may refer to other similar devices that are emphasized (eg, iris color). Preferred lenses are soft contact lenses made from silicone elastomers or hydrogels.

  A lens-forming mixture, or “reactive mixture” or “RMM” (reactive monomer mixture), as used herein, can be cured and crosslinked, or crosslinked to form an ophthalmic lens. Refers to a monomeric or prepolymeric material that can be. The lens-forming mixture contains one or more additives such as UV blocking agents, dyes, photoinitiators, or catalysts, and other additives that may be desired in ophthalmic lenses such as contacts or intraocular lenses. Can be included.

  The lens forming surface refers to a surface used for molding a lens. Any such surface can have an optical quality surface finish, which is a lens surface made by polymerization of lens forming material that is sufficiently smooth in surface and in contact with the molding surface. It shows that it is formed so as to be optically acceptable. Further, the lens forming surfaces 103-104 may include, but are not limited to, spherical, aspheric, and cylindrical powers, wavefront aberration correction, corneal topography correction, and any combination thereof. It is possible to have the geometrical shape necessary for imparting the following optical properties.

  A lithium ion battery refers to an electrochemical cell that generates electrical energy by the movement of lithium ions through the cell. This electrochemical cell, typically called a battery, can be re-energized or recharged to its normal state.

  Media insert, as used herein, refers to a shapeable or rigid substrate that can support an energy source within an ophthalmic lens. The media insert can also support one or more components.

  Mold refers to a rigid or semi-rigid object that can be used to form a lens from an uncured formulation. Some preferred molds include two mold parts that form a front curve mold part and a back curve mold part.

  An optical zone, as used herein, refers to the area of an ophthalmic lens through which an ophthalmic lens wearer sees.

  Electric power, as used herein, refers to work performed per unit time or energy transferred.

  Re-energizable or rechargeable, as used herein, refers to the ability to recover to a higher ability state to do work. In many cases in the present invention, the ability to conduct current at a particular rate and for a particular re-restored time can be used in the context of a recoverable ability.

  Re-energizing or recharging refers to restoring to a state of higher ability to work. In the present invention, it can often be used in connection with restoring a device so that current can flow at a specific rate and for a specific re-recovered time.

  Removed from the mold is either that the lens is completely separated from the mold or is only slightly attached so that it can be removed by light vibrations or pushed off with a cotton swab. Means that.

  A “stacked integrated component device” as used herein and sometimes referred to as a “SIC device” refers to a product having packaging technology capable of assembling thin layers of a substrate, wherein at least a portion of each layer is interconnected. By stacking on top of each other, the electrical and electromechanical devices can be housed in an operable integrated device. Each layer may include various types, materials, shapes and sizes of component devices. Further, the layers may be made by a variety of device production techniques that conform to and take on the various contours that may be desired for the layer.

Molding Referring now to FIG. 1, an illustration of a molding apparatus 100 for an ophthalmic lens is illustrated as having a media insert 111. As used herein, the term mold device 100 refers to dispensing a lens-forming mixture therein such that an ophthalmic lens of the desired shape is produced upon reaction or curing of the lens-forming mixture. A plastic formed in the shape of the cavity 105. The mold and mold assembly 100 of the present invention are composed of a plurality of “mold parts” or “mold pieces” 101 to 102. The mold parts 101-102 can be combined to form a cavity 105 between the mold parts 101-102 in which a lens can be formed. Such a combination of mold parts 101 to 102 is preferably temporary. Once the lens is formed, the mold parts 101-102 can be separated again to remove the lens.

  At least one mold part 101-102 has at least a portion of its surface 103-104 in contact with the lens-forming mixture, and the surface 103-104 is desired upon reaction or curing of the lens-forming mixture. The shape and form are brought to the lens part where the surface is in contact. The same applies to at least one other mold part 101-102.

  Therefore, for example, the mold apparatus 100 includes two portions 101 to 102, that is, a female concave piece (front piece) 102 and a male convex piece (rear piece) 101 (a cavity is formed between them. Is formed). The portion of the concave surface 104 that contacts the lens-forming mixture has the curvature of the front curved portion of the ophthalmic lens produced in the mold apparatus 100 and is sufficiently smooth and in contact with the concave surface 104. The surface of the ophthalmic lens formed by polymerization of the lens forming mixture is formed to be optically acceptable.

  The front mold piece 102 can also include an annular flange that is integral with and surrounds the circular peripheral edge, extending from the flange in a plane extending perpendicular to the axis and extending from the flange (not shown).

  The lens forming surface can include surfaces 103-104 with an optical quality surface finish, which is made by polymerization of a lens forming material that is sufficiently smooth in surface and in contact with the molding surface. It shows that the lens surface is formed to be optically acceptable. Further, the lens forming surfaces 103-104 may include, but are not limited to, spherical, aspheric, and cylindrical powers, wavefront aberration correction, corneal topography correction, and any combination thereof. It is possible to have the geometrical shape necessary for imparting the following optical properties.

  At 111, an energy source 109 and a media insert on which the component 108 is mounted are illustrated. The media insert 111 may be any receptive material on which the energy source 109 may be placed, electrically connecting the circuit path, components, and energy source 109 to the component 108, where the component is energized. Other embodiments useful for allowing current to be drawn from the source 109 may be included.

  The media insert 111 may include a flexible substrate. Additional embodiments may include a rigid media insert 111, such as a silicon wafer. The rigid insert may include an optical zone that provides visual characteristics (such as those utilized for visual correction) and a non-optical zone portion. The energy source may be placed in one or both of the optical zone and the non-optical zone of the insert. Still other embodiments may include an annular insert that is either rigid or formable, or any shape that bypasses the optical zone through which the user sees.

  Another example includes a media insert 111 formed of a clear coat of material that is incorporated into the lens when the lens is formed. The transparent coating can include, for example, pigments, monomers, or other biocompatible materials, as described below.

  The energy source 109 may be placed on the media insert 111 prior to placing the media insert 111 in the mold part used to form the lens. Medium 111 may also include one or more components that receive charge from energy source 109.

  The lens with the media insert 111 may include a flexible skirt design in the rigid center, where the central rigid optical element is in direct contact with the corneal surface at the atmosphere and at each front and back surface; A flexible skirt of lens material (typically a hydrogel material) is attached to the periphery of the rigid optical element, which also acts as a media insert that provides energy and functionality to the resulting ophthalmic lens To do.

  Some examples include a media insert 111, which is a rigid lens insert that is fully encapsulated within a hydrogel matrix. The media insert 111, which is a rigid lens insert, can be manufactured using, for example, a microinjection molding method. For example, poly (4-methylpenta-) having a diameter of about 6 mm to 10 mm, a front surface radius of about 6 mm to 10 mm, and a back surface radius of about 6 mm to 10 mm, and a center thickness of about 0.050 mm to 0.5 mm. 1-ene copolymer resin may be included, a diameter of about 8.9 mm, a front surface radius of about 7.9 mm, a back surface radius of about 7.8 mm, a center thickness of about 0.100 mm, and about 0.050 An insert having a radial edge profile may be included, and a micro-molding machine may include the Microsystem 50 5-ton system provided by Battenfield Inc.

  The media insert can be placed in the mold parts 101-102 utilized to form the ophthalmic lens.

  Examples of the material of the mold parts 101 to 102 may include one or more polyolefins among polypropylene, polystyrene, polyethylene, polymethyl methacrylate, and modified polyolefin. Other molds can also include ceramic or metallic materials.

  Other mold materials that may be combined with one or more additives to form an ophthalmic lens mold include, for example, Zieglar-Natta polypropylene resin (sometimes referred to as znPP). , Purified random copolymers for clean molding according to FDA regulation 21 CFR (c) 3.2, random copolymers with ethylene groups (znPP).

  Still further, the mold may include polymers such as polypropylene, polyethylene, polystyrene, polymethylmethacrylate, modified polyolefins containing alicyclic moieties in the main chain, and cyclic polyolefins. This blend can be used on one or both of the mold halves. Preferably, this blend is used on the back curve, and the front curve is made of an alicyclic copolymer.

  Some preferred methods of making the mold 100 may use injection molding according to known techniques, including molds made by other techniques including, for example, lathe machining, diamond cutting, or laser cutting. Can also be included.

  Typically, the lens is formed on at least one surface of both mold parts 101-102. However, one surface of the lens may be formed from mold parts 101-102, and the other surface of the lens may be formed using a lathe method or other methods.

Lenses Referring now to FIGS. 2A-2D, exemplary designs of media inserts 211-214 are illustrated. FIG. 2A illustrates an annular media insert 211. Other media inserts can be of various shapes that contribute to placement with the ophthalmic lens. Some preferred shapes include shapes having an arcuate design that matches a portion of the overall shape of the ophthalmic lens. FIG. 2B illustrates a media insert 212 that includes approximately half the area of a complete annular design and includes an arcuate region that can surround the optical zone of the lens in which the media insert 212 is placed. . Similarly, FIG. 2C includes a media insert 213 that is approximately one third of the annular design. FIG. 2D illustrates an annular design 214 having a number of separate portions 215, 216, 21 of the media insert 214. Separate portions 215, 216, 21 may be useful for separating the various functions by individual portions 215, 216, 21. For example, one separate portion 215, 216, 21 may include one or more energy sources, and another separate portion 215, 216, 21 may include a component.

  The media inserts 211-214 may optionally have an optical zone that includes variable optics that are powered by an energy source located in the media inserts 211-214. Media inserts 211-214 may also include circuitry for controlling variable optical components contained within optical zones 211-214. In this description, the variable optical component can be recognized as a component.

  The energy source can be in electrical communication with the component. A component may include any device that reacts to charge upon a change of state, such as, for example, a semiconductor chip, a passive electrical device, or an optical device such as a crystalline lens.

  Energy sources include, for example, batteries or other electrochemical cells, capacitors, ultracapacitors, supercapacitors, or other storage components. Lithium ion batteries are located in the media inserts 211-214 around the ophthalmic lens outside the optical zone and are deposited by inkjet via one or more of radio frequency and magnetic inductance. It may be chargeable to the source.

  A preferable lens type includes a lens containing a silicone-containing component. A “silicone-containing component” is a component that contains at least one [—Si—O] unit in a monomer, macromer or prepolymer. Preferably, the total Si and bonds O are present in the silicone-containing component in an amount greater than about 20%, more preferably greater than 30% by weight of the total molecular weight of the silicone-containing component. Useful silicone-containing components preferably include polymerizable functional groups such as acrylate, methacrylate, acrylamide, methacrylamide, vinyl, N-vinyl lactam, N-vinylamide, and styryl functional groups.

式中、
Ｒ^１は、独立して、一価反応性基、一価アルキル基、又は一価アリール基から選択され、前述のいずれかは、ヒドロキシ、アミノ、オキサ、カルボキシ、アルキルカルボキシ、アルコキシ、アミド、カルバメート、カーボネート、ハロゲン、又はこれらの組み合わせから選択される官能基を更に含むこともあり、１−１００ Ｓｉ−Ｏの反復単位を含む一価シロキサン鎖は、アルキル、ヒドロキシ、アミノ、オキサ、カルボキシ、アルキルカルボキシ、アルコキシ、アミド、カルバメート、ハロゲン、又はこれらの組み合わせから選択される官能基を更に含むこともあり、
ｂ＝０〜５００であり、ここでｂが０以外であるとき、ｂの分布が表示値に等しいモードを有すると理解され、少なくとも１つのＲ^１が一価反応性基を含み、いくつかの実施例では、１〜３つのＲ^１が一価反応性基を含む。 Suitable silicone-containing components include compounds of formula I:

Where
R ¹ is independently selected from a monovalent reactive group, a monovalent alkyl group, or a monovalent aryl group, and any of the foregoing is hydroxy, amino, oxa, carboxy, alkylcarboxy, alkoxy, amide, carbamate The monovalent siloxane chain containing repeating units of 1-100 Si-O may further comprise a functional group selected from carbonate, halogen, or a combination thereof, and may be alkyl, hydroxy, amino, oxa, carboxy, alkyl May further comprise a functional group selected from carboxy, alkoxy, amide, carbamate, halogen, or combinations thereof;
When b = 0 to 500, where b is non-zero, it is understood that the distribution of b has a mode equal to the indicated value, at least one R ¹ contains a monovalent reactive group, In the examples, 1-3 R ¹ contain a monovalent reactive group.

As used herein, a “monovalent reactive group” is a group that can undergo free radical and / or cationic polymerization. Non-limiting examples of free radical reactive groups include (meth) acrylate, styryl, vinyl, vinyl ether, C _1-6 alkyl (meth) acrylate, (meth) acrylamide, C _1-6 alkyl (meth) acrylamide, N-vinyl lactam, N-vinyl amide, C _2-12 alkenyl, C _2-12 alkenyl phenyl, C _2-12 alkenyl naphthyl, C _2-6 alkenyl phenyl C _1-6 alkyl, O-vinyl carbamate and O-vinyl carbonate Is mentioned. Non-limiting examples of cation reactive groups include vinyl ether or epoxide groups and mixtures thereof. In one embodiment, the free radical reactive group includes (meth) acrylate, acrylicoxy, (meth) acrylamide, and mixtures thereof.

Suitable monovalent alkyl and aryl groups include unsubstituted monovalent C ₁ such as substituted and unsubstituted methyl, ethyl, propyl, butyl, 2-hydroxypropyl, propoxypropyl, polyethyleneoxypropyl, combinations thereof, and the like. -C ₁₆ alkyl groups _include C 6 _{-C 14} aryl group.

In one example, b is zero, one R ¹ is a monovalent reactive group, at least three R ¹ are selected from monovalent alkyl groups having ¹ to 16 carbon atoms; In another embodiment, it is selected from monovalent alkyl groups having 1 to 6 carbon atoms. Non-limiting examples of silicone components include 2-methyl-, 2-hydroxy-3- [3- [1,3,3,3-tetramethyl-1-[(trimethylsilyl) oxy] disiloxanyl] propoxy] propyl ester ( “SiGMA”),
2-hydroxy-3-methacryloxypropyloxypropyl-tri (trimethylsiloxy) silane,
3-methacryloxypropyltris (trimethylsiloxy) silane ("TRIS"),
3-methacryloxypropylbis (trimethylsiloxy) methylsilane, and 3-methacryloxypropylpentamethyldisiloxane are included.

In another example, b is 2-20, 3-15, or 3-10, at least one terminal R ¹ contains a monovalent reactive group, and the remaining R ¹ is 1-16 Selected from monovalent alkyl groups having carbon atoms, and in another embodiment, selected from monovalent alkyl groups having 1 to 6 carbon atoms. In yet another embodiment, b is 3-15, one terminal R ¹ contains a monovalent reactive group, and the other terminal R ¹ contains a monovalent alkyl group having 1-6 carbon atoms. The remaining R ¹ comprises a monovalent alkyl group having ¹ to 3 carbon atoms. Non-limiting examples of silicone components include (mono- (2-hydroxy-3-methacryloxypropyl) -propyl ether terminated polydimethylsiloxane (400-1000 MW)) (“OH-mPDMS”), monomethacryloxypropyl terminated mono -N-butyl terminated polydimethylsiloxane (800-1000 MW), ("mPDMS").

In another embodiment, b is 5 to 400 or from 10 to 300, both terminal ^{R 1} comprises a monovalent reactive group and the remaining ^{R 1} is independently an ether bond between the carbon atoms It is selected from monovalent alkyl groups having 1 to 18 carbon atoms that may have and may further contain halogen.

  In one example, if a silicone hydrogel lens is desired, the lens is at least about 20 wt%, preferably about 20-70 wt% silicone-containing component, based on the total weight of reactive monomer components from which the polymer is made. From a reaction mixture comprising

式中、ＹはＯ−、Ｓ−又はＮＨ−を意味し、
Ｒは、水素又はメチルを意味し、ｄは１、２、３又は４であり、ｑは０又は１である。 In another embodiment, 1-4 R ¹ comprise a vinyl carbonate or vinyl carbamate of the formula:

In the formula, Y means O-, S- or NH-,
R means hydrogen or methyl, d is 1, 2, 3 or 4 and q is 0 or 1.

を含む。 Specific examples of the silicone-containing vinyl carbonate or vinyl carbamate monomer include 1,3-bis [4- (vinyloxycarbonyloxy) but-1-yl] tetramethyl-disiloxane, 3- (vinyloxycarbonylthio) propyl. -[Tris (trimethylsiloxy) silane], 3- [tris (trimethylsiloxy) silyl] propylallylcarbamate, 3- [tris (trimethylsiloxy) silyl] propylvinylcarbamate, trimethylsilylethylvinylcarbonate, trimethylsilylmethylvinylcarbonate, and

including.

When a biomedical device having an elastic modulus of about 200 or less is desired, only one R ¹ will contain monovalent reactive groups, and no more than two of the remaining R ¹ groups will contain monovalent siloxanes. Contains groups.

Ｒ^１１は独立して、アルキル又は１〜１０個の炭素原子を有するフルオロ置換アルキル基を意味し、これには炭素原子間にエーテル結合を含んでよく、ｙは少なくとも１であり、ｐは４００〜１０，０００の部分重量を提供し、Ｅ及びＥ^１はそれぞれ独立して、次式に示される重合性不飽和有機ラジカルを意味する。

式中、Ｒ^１２は水素又はメチルであり、Ｒ^１３は水素、１〜６個の炭素原子を有するアルキルラジカル又はａ−ＣＯ−Ｙ−Ｒ^１５ラジカルであり、Ｙは−Ｏ−、Ｙ−Ｓ−、又は−ＮＨ−であり、Ｒ^１４は１〜１２個の炭素原子を有する二価ラジカルであり、Ｘは−ＣＯ−又は−ＯＣＯ−を意味し、Ｚは−Ｏ−又は−ＮＨ−を意味し、Ａｒは６〜３０個の炭素原子を有する芳香族ラジカルを意味し、ｗは０〜６であり、ｘは０又は１であり、ｙは０又は１であり、ｚは０又は１である。 Another class of silicone-containing components includes polyurethane macromers of the formula:
Formulas IV-VI
^{(* D * A * D *} G) a * D * D * E 1;
E ( ^* D ^* G ^* D ^* A) _a ^* D ^* G ^* D ^* E ¹ or;
E ( ^* D ^* A ^* D ^* G) _a ^* D ^* A ^* D ^* E ¹
Where
D represents an alkyl diradical, alkylcycloalkyl diradical, cycloalkyl diradical, aryl diradical or alkylaryl diradical having 6 to 30 carbon atoms;
G represents an alkyl diradical, cycloalkyl diradical, alkylcycloalkyl diradical, aryl dialkyl radical or alkylaryl diradical having 1 to 40 carbon atoms, which contains an ether, thio or amine linkage in the main chain. Good.
^* Means urethane or ureido bond,
_a is at least 1,
A means a divalent polymerization radical of the following formula.

R ¹¹ independently represents alkyl or a fluoro-substituted alkyl group having 1 to 10 carbon atoms, which may include an ether bond between carbon atoms, y is at least 1, and p is 400 Providing a partial weight of from 10,000 to 10,000, E and E ¹ each independently represent a polymerizable unsaturated organic radical represented by the following formula:

Wherein R ¹² is hydrogen or methyl, R ¹³ is hydrogen, an alkyl radical having 1 to 6 carbon atoms or an a-CO—Y—R ¹⁵ radical, and Y is —O—, Y—S. —, Or —NH—, R ¹⁴ is a divalent radical having 1 to 12 carbon atoms, X means —CO— or —OCO—, and Z represents —O— or —NH—. Means Ar is an aromatic radical having 6 to 30 carbon atoms, w is 0 to 6, x is 0 or 1, y is 0 or 1, and z is 0 or 1. It is.

Ｒ^１６は、イソホロンジイソシアネートのジラジカルなどのイソシアネート基除去後のジイソシアネートのジラジカルである。別の好適なシリコーン含有マクロマーは、フルオロエーテル、ヒドロキシ末端ポリジメチルシロキサン、イソホロンジイソシアネート及びイソシアネートエチルメタクリレートの反応によって形成される式Ｘ（式中、ｘ＋ｙは１０〜３０の範囲の数である）の化合物である。

One preferred silicone-containing component is a polyurethane macromer represented by the following formula:

R ¹⁶ is a diradical of a diisocyanate after removal of an isocyanate group such as a diradical of isophorone diisocyanate. Another suitable silicone-containing macromer is a compound of formula X formed by the reaction of fluoroether, hydroxy-terminated polydimethylsiloxane, isophorone diisocyanate and isocyanate ethyl methacrylate, where x + y is a number in the range of 10-30. It is.

  Other silicone-containing components suitable for use in the present invention include polysiloxanes, polyalkylene ethers, diisocyanates, polyfluorinated hydrocarbons, polyfluorinated ethers, and macromers containing polysaccharide groups, substituted with terminal difluoro. Polysiloxanes with polar fluorinated grafts or side groups having hydrogen atoms bonded to carbon atoms, hydrophilic siloxanyl methacrylates containing ethers, and siloxanyl bonds and crosslinking monomers containing polyethers and polysiloxanyl groups included. Any of the aforementioned polysiloxanes can also be used in the present invention as a silicone-containing component.

Process The following method steps are given as examples of processes that may be performed according to some aspects of the present invention. It should be understood that the order in which the steps of the method are presented is not intended to be limiting and that the invention may be practiced using other orders. In addition, not all steps are required to practice the present invention, and various embodiments of the present invention may include additional steps.

  Referring now to FIG. 4, a flowchart illustrates steps that may be used to implement the present invention, where an energy source is placed on a media insert at 401. The media insert may or may not include one or more components.

  At 402, a reactive monomer mixture can be deposited in the first mold part.

  At 403, the media insert is placed in a cavity formed by the first mold part. The media insert 111 may be placed in the mold parts 101-102 by mechanical placement. Mechanical placement may include, for example, a robot or other automated operator, such as those known in the industry to place surface mount components. Human placement of the media insert 111 is also within the scope of the present invention. Thus, to place the media insert 111 along with the energy source 109 in the mold portion such that the polymerization of the reactive mixture 110 contained in the mold portion includes the energy source 109 in the resulting ophthalmic lens. Arbitrary mechanical placement is effective.

  A processor device, MEMS, NEMS, or other component may also be mounted on the media insert and in electrical communication with the energy source.

  At 404, a first mold part is placed adjacent to a second mold part to form a lens to form a lens forming cavity with at least some of the reactive monomer mixture and an energy source therein. be able to. At 405, the reactive monomer mixture in the cavity can be polymerized. Polymerization can be accomplished, for example, by exposure to either or both actinic radiation and heat. At 406, the lens is removed from the mold portion.

  While the present invention can be used to provide hard or soft contact lenses made from any known lens material, or materials suitable for the manufacture of such lenses, preferably the lenses of the present invention are about A soft contact lens having a moisture content of 0 to about 90 percent. More preferably, the lens is made from monomer-containing hydroxy groups, carboxyl groups, or both, or from silicone-containing polymers such as siloxanes, hydrogels, silicone hydrogels, and combinations thereof. Materials useful for forming the lenses of the present invention can be made by reacting blends of macromers, monomers, and combinations thereof, in addition to additives such as polymerization initiators. Suitable materials include, but are not limited to, silicone hydrogels made from silicone macromers and hydrophilic monomers.

  Referring again to FIG. 4, at 402, the reactive mixture is placed between the first mold portion and the second mold portion, and at 403, the media insert is positioned in contact with the reactive mixture. . At 404, a first mold part is placed adjacent to a second mold part to form a lens cavity with a reactive monomer mixture and medium therein.

  At 405, the reaction mixture is polymerized, such as through exposure to actinic radiation and / or heat. At 406, the ophthalmic device incorporating the media insert and the energy source is removed from the mold portion used to form the ophthalmic device.

  Referring now to FIG. 5, in another aspect of the present invention, a media insert incorporated into an ophthalmic device can be powered by an incorporated energy source. At 501, a media insert is placed in an ophthalmic lens as described above. At 502, the media insert is incorporated into the media insert or otherwise placed in electrical communication with components included in the ophthalmic lens 105. Electrical continuity can be achieved, for example, by circuitry incorporated within the media insert or by ink jets or otherwise formed in the lens material directly.

  At 503, energy is directed to components incorporated into the ophthalmic lens. The energy can be directed, for example, by an electrical circuit that can conduct charge. At 504, the component performs certain operations based on the energy directed to the component. The functions may include certain information processing operations, including one or more of mechanical operations that affect the lens, or receiving, transmitting, storing, and manipulating information. Embodiments will include information that is processed and stored as digital values.

  At 505, information can be transmitted from components incorporated in the lens.

Apparatus Referring now to FIG. 3, an automated apparatus 310 is illustrated as having a transport boundary 311 for one or more media inserts 314. As illustrated, a number of mold sections, each with an associated media insert 314, are received on a pallet 313 and sent to a media transport boundary 311. Embodiments can include a single boundary for individually placing media inserts 314, or multiple boundaries for placing media inserts 314 simultaneously in multiple mold sections (in some embodiments, in each mold). Part (not shown).

  Another aspect includes an apparatus that supports the media insert 314 while simultaneously molding the body of the ophthalmic lens around these components. The energy source may be attached to a holding point of a lens mold (not illustrated). The holding point may be fixed by the same kind of polymer material as that forming the lens body.

  Referring now to FIG. 6, a controller 600 that can be used in some embodiments of the present invention is illustrated. Controller 600 includes one or more processors 610 that may include one or more processor components coupled to communication device 620. In some embodiments, the controller 600 can be used to transfer energy to an energy source that is placed in the ophthalmic lens.

  The processor 610 is coupled to a communication device configured to transfer energy via a communication channel. The communication device is an automation used to place a medium having an energy source in an ophthalmic lens mold part, as well as to components mounted on the medium and placed in the ophthalmic lens mold part. And can be used to electrically control one or more of the transmission of digital data from now on or to control components incorporated within an ophthalmic lens.

  The communication device 620 may also be used to communicate with, for example, one or more controller devices or manufacturing equipment components.

  The processor 610 also communicates with the storage device 630. Storage device 630 includes any magnetic storage device (eg, magnetic tape and hard disk drive), optical storage device, and / or semiconductor storage device such as a random access memory (RAM) device and a read only memory (ROM) device. An appropriate information storage device may be provided.

  The storage device 630 can store a program 640 for controlling the processor 610. The processor 610 executes the instructions of the software program 640 and thereby operates according to the present invention. For example, the processor 610 may receive information describing media insert placement, component placement, and the like. The storage device 630 may also store ophthalmic related data in one or more databases 650 and 660. The database can include customized media insert designs, metrological data, and specific control sequences for controlling energy entering and exiting the media insert.

  Referring to FIG. 7, a top-down depiction of the media insert 700 is shown. In this depiction, the energy source 710 is illustrated in the peripheral portion 711 of the media insert 700. The energy source 710 may include, for example, a thin film rechargeable lithium ion battery. An energy source 710 may be connected with the contact point 714 to allow interconnection. The wire may be wire bonded to the contact point 714 and connect the energy source 710 to a photocell 715 that may be used to reapply energy to the battery energy source 710. Additional wires may connect the energy source 710 to the flexible circuit interconnect through wire-connected contacts.

  Media insert 700 may include a flexible substrate. This flexible substrate can be formed into a shape similar to that of a typical lens in the same manner as described above. However, to add additional flexibility, media insert 700 may include additional shape features along its length, such as radial cuts. Various electrical components 712 may also be included, such as integrated circuits, separate components, passive components, and such devices.

  An optical zone 713 is also illustrated. The optical zone may be optically passive with no optical changes, or it may have defined optical characteristics, such as defined optical corrections. Still other embodiments of the lens include an optical zone having variable optical components that can be varied by command.

  Referring to FIG. 8, a cross-sectional view of media insert 800 is illustrated. The media insert 800 may include the optical zone 830 described above, and also one or more peripheral portions 810-820. Media inserts and components may be placed in the peripheral portions 810-820.

  In some embodiments, there may be methods that affect the appearance of the ophthalmic lens. The aesthetics of the thin film microbattery surface can be altered in a variety of ways, which exhibit a particular appearance when embedded in an electroactive contact lens or molded hydrogel article. For example, a thin film microbattery may be manufactured to have a packaging material that has an aesthetically pleasing pattern and / or color, which provides a subdued appearance of thin film microbattery or otherwise. Provides a light purple-like color pattern, colorless and / or mixed color pattern, reflective design, nacreous design, metallic design, or potentially any other aesthetic design or pattern Can function to. In other embodiments, the thin film battery is made up of other components in the lens, such as a photovoltaic chip attached to the front surface of the battery, or alternatively all or part of the flexible circuit. It may be partially hidden by placing the battery on the rear side. Further, the thin film battery may be systematically arranged such that the upper or lower ridge partially or entirely hides the battery visibility. It will be apparent to those skilled in the art that there are many examples of the appearance of energized ophthalmic devices and how to define them.

  There can be many examples of how to form the various types of energized ophthalmic devices described. Certain embodiments described herein may include assembling specific energy-supplied ophthalmic lens sub-components in separate steps. For advantageously shaped thin film microcells, flexible circuits, interconnects, microelectronic components, and / or other electroactive components used with biocompatible, inert, conformal coatings The “offline” assembly provides a single package that is comprehensive and embeddable that can simply be incorporated into standard contact lens manufacturing processes. Flexible circuits may include those made from copper-coated polyimide film, or other similar substrates. For conformal coatings, parylene (grades N, C, D, HT, and any combination thereof), poly (p-xylylene), insulating coating, silicone conformal coating, or any other advantageous biocompatible Non-limiting coatings.

  Some examples of the present invention may be methods that direct the shape design of thin film microcells that are shaped to accommodate embodiments within and / or encapsulated by ophthalmic lens materials. Other examples include hydrogels, silicone hydrogels, rigid gas permeable “RGP” contact lens materials, silicones, thermoplastic polymers, thermoplastic elastomers, thermoset polymers, conformal insulation / dielectric coatings, and hermetic barrier coatings. Can include methods of incorporating thin film microbatteries into various materials, including but not limited to.

  Other embodiments may include a method of planned placement of an energy source within an ophthalmic lens shape. Specifically, the energy source can be a translucent article. Since the energy source may not interfere with the transmission of light through the ophthalmic lens, the design method ensures that the center 5-8 mm of the contact lens cannot be obstructed by any translucent part of the energy source. Can be sure. It can be apparent to those skilled in the art that there can be many different embodiments related to the design of various energy sources to interact well with the optically relevant parts of the ophthalmic lens.

  The volume and density of the energy source can also work with other lens stabilization zones that are designed in the body of the ophthalmic lens so that the energy source described above can also stabilize the lens rotatably on the eye. As such, design can be facilitated. Examples of such include, but are not limited to, astigmatism correction, improved comfort on the eye, or stable / controlled placement of other components within the energized ophthalmic lens. It can be advantageous in many applications.

  In addition, the energy source is placed in a fixed position from the outer edge of the contact lens to provide good comfort and at the same time minimize the occurrence of adverse events. An advantageous design may be possible. Examples of such adverse events to be avoided include epithelial arcuate lesions or giant papillary conjunctivitis.

  As a non-limiting example, the cathode, electrolyte, and anode features of an embedded electrochemical cell can be formed by a suitable printed ink that is shaped to define such cathode, electrolyte, and anode areas. Batteries thus formed can be rechargeable based on lithium chemistry similar to that of, for example, manganese oxide and zinc chemistry, and thin film battery chemistry described above. Both thin batteries can be included. It can be apparent to those skilled in the art that various mechanisms of energy-supplied ophthalmic lenses, and various different embodiments of forming methods, can include the use of printing techniques.

  In addition, an energy harvester may be included and placed in electrical conduction in a manner that allows the energy harvester to charge one or more energy sources. For example, the energy harvester may include a photovoltaic cell, a thermoelectric cell, or a piezoelectric cell. Harvesters have a positive aspect in that they can absorb energy from the environment and thus provide electrical energy without an external wired connection. The harvester may include an energy source in an energized ophthalmic lens. However, the energy harvester may be combined with other energy sources that can store energy in the form of electricity.

  Another type of energy source involves the use of capacitor type devices. It can be apparent that the capacitor can provide a solution with an energy density higher than that of the energy harvester but lower than that of the battery.

  Capacitors are a type of energy source that stores energy in the form of electricity, and thus can be one of the energy sources that can be combined with an energy harvester to create a wireless energy source capable of storing energy. In general, capacitors have an advantage over batteries in that they generally have a higher power density than batteries. There are many different types of capacitors ranging from standard electrical thin film capacitors to Mylar capacitors, electrolytic capacitors, and relatively new, more advanced technology, high density nano-sized capacitors, or supercapacitor technologies.

  Further, an energy source including an electrochemical cell or battery can define a relatively desirable operating point. The battery has many advantageous features. For example, batteries store energy in a form that is directly converted to electrical energy. Some batteries may recharge or re-apply energy and thus may present another category of energy source that can be coupled with an energy harvester. Batteries are generally capable of relatively high energy densities, and energy battery storage can perform functions with relatively high energy requirements compared to other miniaturized energy sources. In addition, the battery can be assembled into a flexible shape. It may be known to those skilled in the art that for applications requiring high electrical capability, the battery can also be coupled to a capacitor. There can be many embodiments that include a battery as at least a portion of the energy source in the energized lens.

  A fuel cell may be included as an energy source. Fuel cells produce electricity by consuming a chemical fuel source, which in turn produces by-products including electricity and thermal energy. The energy source of a fuel cell may be possible by using a bioavailable material as the fuel source.

  There are many different types of batteries that can be included in an energized ophthalmic lens. For example, single use batteries can be formed from various cathode and anode materials. As non-limiting examples, these materials can include one or more of zinc, carbon, silver, manganese, cobalt, lithium, and silicon. Yet another embodiment is obtained through the use of a rechargeable battery. Such batteries can in turn be made from one or more of lithium ion technology, silver technology, magnesium technology, niobium technology, or other current supplying materials. It will be apparent to those skilled in the art that various current battery technologies for single use or rechargeable battery systems can include an energy source for an energized ophthalmic lens.

  The physical and dimensional constraints of the contact lens environment can contribute to thin film batteries. Thin film batteries can occupy a small space compatible with human ophthalmic embodiments. In addition, they may be formed on a flexible substrate, allowing the body of both the ophthalmic lens and the included battery to flex freely with the substrate.

  In the case of thin film batteries, examples may include single charge and rechargeable forms. Rechargeable batteries provide a longer usable product life, and thus a higher energy consumption capability. Many development activities have focused on technologies for producing electrically energized ophthalmic lenses with rechargeable thin film batteries, however, the technology of the present invention falls into this subclass. It is not limited.

  Rechargeable thin film batteries are commercially available, for example Oak Ridge National Laboratory, which has been manufactured in various forms since the early 1990s. Current commercial manufacturers of such batteries include Excelcellon Solid State, LLC (Atlanta, GA), Infinite Power Solutions (Littleton, CO), and Cyberbet Corporation (Elk River, MN). In this technology, the use of including flat thin film batteries is currently dominant. Use of such a battery can include forming the thin film battery into a three-dimensional shape having, for example, a spherical radius of curvature. Many shapes and forms of such three-dimensional batteries are within the scope of the present invention.

Stacked integrated component media inserts Thin film batteries and / or energized electronic elements may be included in a media insert in the form of a stacked integrated component. Proceeding to FIG. 9, a cross-sectional view of this type of item 900, which is a non-limiting example, is provided. Media inserts may include many different types of layers that are encapsulated in a form that is compatible with the ocular environment they occupy. Inserts having these stacked integrated component layers may take the overall shape of the insert, as shown in the various representative shapes of FIGS. 2A, 2B, 2C, and 2D. Alternatively, in some cases, the media insert may take a shape such that the stacked integrated component occupies only a partial volume of the overall shape.

  Continuing with the example of item 900, the stacked integrated component media insert may have many functional aspects. As shown in FIG. 9, a thin film battery may include one or more layers stacked on top of each other, where layers 906 and 907 represent battery layers having multiple components in the layers. obtain. One such battery component can be found as item 940. As can be seen in almost all layers, two layers stacked on top of each other may be interconnected. In the state of the art, there can be many ways to make these interconnections, but they may be interconnected by solder ball interconnections between layers 907 and 908 as shown in items 930 and 931. In some cases, only these connections may be required, but in other cases the solder balls may contact other interconnect elements, for example by layer vias. In the components in layer 907 having interconnects 930 and 931, there may be through substrate vias passing electrical connections from one side of the components to the other in the body of the thin film battery component. Next, some of these pass-through substrate components form another interlayer connection to the layer above this component, as is the case with component 940, on the other layers of the substrate. Good.

  In other layers of the stacked integrated component media insert, there may be a layer dedicated to interconnecting the various components in the interconnect layer, such as layer 905. This layer may include vias and routing lines that carry signals from various components to other components. For example, 905 can provide various battery element connections to a power management device that can be present in the technology layer component of layer 904. The interconnect layer can also be connected to components outside the technology layer, as can be present in an integrated passive element component, such as shown in item 920, as well as being able to connect between components in the technology layer. Can connect. There can be many ways in which electrical signal routing can be supported by the presence of a dedicated interconnect layer.

  There are two features, items 904 and 902, identified as technology layers. These features represent a variety of technology options that can be included in the media insert. One of the layers may include CMOS, BiCMOS, bipolar, or memory based technologies, while the other layer may include different technologies. Alternatively, the two layers may represent different technology lines within the same overall lineage, for example, layer 902 may include electronic elements made using 0.5 micrometer CMOS technology, and layer 904 May include elements fabricated using 20 nanometer CMOS technology. It will be apparent that many other combinations of various types of electronics technologies fit within the technology described herein.

  There may be additional interconnect layers similar to layer 905. The additional layer may be another interconnect full layer, as shown in item 903. Alternatively, the additional layer may be part of a stack, as shown in item 910. In some cases, these additional elements may provide electrical interconnects, while on the other hand may be structural interconnects implemented by the presence of layers. Both structural and electronic interconnects may be included between the various layers.

  As described above, the media insert may include a region for electrical interconnection to components outside the insert. However, in other embodiments, the media insert may include interconnections to external components in a wireless manner. In such a case, a typical method of wireless communication can be provided by using an antenna. As shown in item 901, there may be a layer in which such a representative antenna may be supported within the layer. In many cases, such an antenna layer can be located at the top or bottom of the stacked integrated component device within the media insert. As shown in item 908, such a layer at the top or bottom does not include an antenna for wireless communication and can therefore be used as a support substrate on which a stacked device is made.

  In some examples shown herein, battery elements may be included as elements in the at least one stack itself. It may also be noted that other embodiments where the battery element is located outside the stacked integrated component layer may be possible. Still further, individual batteries or other energy supply components may be present in the media insert, or these individual energy supply components may be located external to the media insert.

  Proceeding to FIG. 10, item 1040 is depicted in item 1000 of the laminated integrated component media insert, item 1030 ophthalmic lens. The media insert material boundary is delineated by a feature labeled 1040. In this example, the stacked integrated component layer shown as item 1010 is located within the media insert. In some such examples, an electroactive lens can be represented as item 1020 within the ophthalmic lens 1030, but outside the media insert. Control signals for the components in the lens can be generated from the radio signal. Also, the stacked component layers in the media insert can receive this wireless signal, and in some cases adjust the electrical signal routed to the wire that goes outside of the media insert 1040 to activate the electrical activity. Connected to lens 1020. There may be many options for using and interfacing media inserts that include stacked integrated components within an ophthalmic lens, and in a non-limiting sense, various types of energy-supplied other than ophthalmic lenses. It will be apparent that stacked integrated components may be included in devices such as biomedical devices.

  Various embodiments and aspects of the invention are described below.

  A method of forming a laminated integrated component media insert for an ophthalmic lens is provided. The method includes the steps of forming a functional base material layer, assembling the base material layer, forming an electrical interconnect between the base material layers, and in a molded ophthalmic lens body. Encapsulating the laminating mechanism with a bonding material.

  One of the layers of the stacked integrated component media insert may comprise a solid energy source.

  The stacked integrated component media insert may comprise an annular shape.

  The stacked integrated component media insert may comprise an arcuate shape.

  The method may additionally include placing a variable focus lens proximate to the stacked integrated component media insert.

  The variable focus lens may be secured to the laminated integrated component media insert.

  At least some of the one or more layers may comprise an adhesive film.

  Two or more layers may be adhered to each other with at least a portion of one or more layers via an adhesive film.

  The laminate may be encapsulated with one or more materials that can be bonded into the body of the ophthalmic lens.

  One or more of the encapsulating materials may include a polysilicone-based polymer.

  The layer may comprise a semiconductor substrate having an electronic circuit proximate to the first surface.

  The method may additionally include a layer having one or more substrates having a layer for the electrochemical energy supply component.

  At least one layer in the stacked integrated component media insert may include a semiconductor layer with electronic circuitry capable of controlling the flow of current from the electrochemical cell.

  The method may additionally include an electroactive lens component within the ophthalmic device.

  The electronic circuit may be electrically connected to an electroactive lens component in the ophthalmic device.

  The layer may comprise one or more metal layers that function as an antenna.

  The base material layer may be assembled into a circular annular shape or one shape of a part of the annular shape.

  The stacked functional layer can be adhered to the insulating layer to form a stacking mechanism.

  The integrated component layer insert may include one or more layers that are molded into at least a portion of the circular annulus.

  One or more layers may be electrically connected to the second layer with at least one solder ball located between them.

  One or more layers may be electrically connected to the second layer with at least a wire bond between the contact pads located between them.

  The second stacked integrated component layer may be molded into at least a portion of a circular ring having a smaller outer radius than the first layer.

  One or more layers may comprise a metallic feature surface.

  The solder film may be placed on the surface of one or more layers with metallic characteristics.

  A laminated integrated component layer insert is provided. The laminated integrated component layer insert includes a substrate layer having functionality, the substrate layer being assembled to form an electrical interconnect between the substrate layers and providing a lamination mechanism, the lamination mechanism Is encapsulated with a binding material within the body of the molded ophthalmic lens.

  One of the stacked integrated component layers, ie the layer of media insert, may comprise a solid energy source.

  The laminated integrated component layer, i.e. the media insert, may comprise an annular shape.

  The laminated integrated component layer, ie the media insert, may comprise an arcuate shape.

  The laminated integrated component layer insert may additionally include placing the variable focus lens proximate to the laminated integrated component layer, ie, the media insert.

  The variable focus lens is fixed to the laminated integrated component layer, ie the media insert.

  At least some of the one or more layers may comprise an adhesive film.

  Two or more layers may be adhered to each other with at least a portion of one or more layers via an adhesive film.

  The laminate may be encapsulated with one or more materials that can be bonded into the body of the ophthalmic lens.

  One or more of the encapsulating materials may include a polysilicone-based polymer.

  The layer may comprise a semiconductor substrate having an electronic circuit proximate to the first surface.

  The laminated integrated component layer insert may additionally include a layer having one or more substrates having layers for electrochemical energy supply components.

  The stacked integrated component layer, i.e., at least one layer in the media insert, may comprise a semiconductor layer with electronic circuitry capable of controlling the flow of current from the electrochemical cell.

  The laminated integrated component layer insert may additionally include an electroactive lens component within the ophthalmic device.

  The electronic circuit is electrically connected to an electroactive lens component in the ophthalmic device.

  The layer may comprise one or more metal layers that function as an antenna.

  The base material layer may be assembled into a circular annular shape or one shape of a part of the annular shape.

  The stacked functional layer can be adhered to the insulating layer to form a stacking mechanism.

  The integrated component layer insert may include one or more layers that are molded into at least a portion of the circular annulus.

  One or more layers may be electrically connected to the second layer with at least one solder ball located between them.

  One or more layers may be electrically connected to the second layer with at least a wire bond between the contact pads located between them.

  The second stacked integrated component layer may be molded into at least a portion of a circular ring having a smaller outer radius than the first layer.

  One or more layers may comprise a metallic feature surface.

  The solder film may be placed on the surface of one or more layers with metallic characteristics.

  An apparatus for manufacturing a stacked integrated component media insert is described. The device has a generally conical rigid protruding surface, a shelf along the edge of the protruding surface that serves to support the placement of a thin layer on the exposed surface of the shelf, and an orientation of the conical protruding surface. An alignment feature along.

  At least a portion of the protruding surface may be coated with a non-adhesive surface film.

  The non-adhesive surface film may be a Teflon formulation.

  This device may additionally be equipped with automation for the in-place treatment of the pieces laminated to the protruding surface.

  The device is a digital storage device including automation control processor and software executable on demand, such software working with the processor to place the functionalized layer insert in the mold part. And a digital storage device.

  The processor may be capable of receiving a programmed command set from a network that is logically connected to such processor.

CONCLUSION As described above and as further defined in the claims below, a method of forming a media insert, a media insert and apparatus for performing such a method, and a media insert A formed ophthalmic lens is provided.

Embodiment
(1) A method for forming a laminated integrated component media insert for an ophthalmic lens comprising:
Forming a functional base material layer;
Assembling the base material layer;
Forming an electrical interconnect between the substrate layers;
Encapsulating a lamination mechanism with a bonding material within the body of a molded ophthalmic lens.
(2) The method according to embodiment 1, wherein the base material layer is assembled into one of a circular annular shape or a part of the annular shape.
(3) The method according to embodiment 1 or 2, wherein the laminated functional layer is adhered to an insulating layer to form a lamination mechanism.
(4) The method according to any of embodiments 1-3, wherein the second laminated integrated component layer is formed into at least a portion of a circular ring having a smaller outer radius than the first layer.
(5) A method according to any of embodiments 1-4, wherein one or more of the layers comprises a metallic feature surface.

6. The method of embodiment 5, wherein a solder film is placed on the surface of the one or more layers with metallic characteristics.
(7) Embodiment 1 comprising disposing a battery on the stacked integrated component media insert, wherein the battery is rechargeable via one or more of radio frequency and magnetic inductance. The method in any one of -6.
(8) In any of the embodiments 1-7, comprising the steps of disposing a thin film battery on the stacked integrated component medium insert and changing the surface of the battery to define the appearance of the battery. The method described.
(9) The method according to any one of embodiments 1 to 8, wherein the base material layer is flexible.
10. A method comprising: forming a laminated integrated component media insert according to any of embodiments 1-9; and coupling the media insert into an ophthalmic lens.

(11) A laminated integrated component layer insert,
A functional substrate layer assembled to form an electrical interconnect between the substrate layers and providing a laminating mechanism;
A laminated integrated component layer insert, wherein the lamination mechanism is encapsulated with a bonding material within the body of a molded ophthalmic lens.
(12) The laminated integrated component layer insert according to embodiment 11, wherein the substrate layer is assembled into one of a circular annular shape or a part of an annular shape.
(13) The stacked integrated component layer insert according to embodiment 11 or 12, wherein the stacked functional layer is bonded to an insulating layer to form a stacking mechanism.
14. The stack of any of embodiments 11, 12, or 13, wherein the second stacked integrated component layer is molded into at least a portion of a circular ring having an outer radius that is smaller than the first layer. Mold integration component layer insert.
15. The stacked integrated component layer insert according to any of embodiments 11, 12, or 13, wherein one or more layers comprise a metallic feature surface.

16. The stacked integrated component layer insert of embodiment 15, wherein a solder film is placed on the surface of the one or more layers comprising metallic features.
(17) Any of embodiments 11, 12, 13, 14, 15, or 16 comprising a battery configured to be rechargeable via one or more of radio frequency and magnetic inductance. A laminated integrated component layer insert as described.
(18) The stacked type according to any one of embodiments 11, 12, 13, 14, 15, 16, or 17, which includes a thin film battery, and the surface of the thin film battery is configured to define a predetermined appearance. Integrated component layer insert.
(19) The laminated integrated component layer insert according to any of embodiments 11, 12, 13, 14, 15, 16, 17, or 18, wherein the substrate layer is flexible.
(20) An ophthalmic lens comprising the laminated integrated component layer insert according to any of embodiments 11-19 coupled therein.

Claims (20)

A laminated integrated component layer media insert for an ophthalmic lens comprising :
A plurality of base material layers forming the laminated and stacked mechanism, each of the base layer, the energy source, or include an electrically connected functional component to the energy source, the plurality of substrates At least one of the layers includes the energy source, the plurality of substrate layers are laminated to each other, the at least two substrate layers have different sizes, and the laminated integrated component layer media insert is an ophthalmic lens When the substrate layer located in the rear has a larger outer diameter than the substrate layer located in the front, the region defined by the substrate layer located in the front of the substrate layer located in the rear A plurality of base material layers overlapping at a position included in a predetermined region ;
A conductive connection for connecting the energy source on the plurality of substrate layers to the functional component;
A layer of material encapsulating the stacking mechanism;
A laminated integrated component layer media insert comprising:   The laminated integrated component layer media insert of claim 1, wherein the plurality of substrate layers have an annular shape or one of a portion of an annular shape.   The laminated integrated component layer media insert according to claim 1 or 2, wherein the plurality of substrate layers are adhered to one or more insulating layers. At least two of the base material layers have at least a part of an annular shape, and one outer diameter of the annular base material layer is smaller than another outer diameter of the other annular base material layer. The at least two base layers are disposed outside an optical zone of the ophthalmic lens when disposed in the ophthalmic lens. A laminated integrated component layer media insert as described.   The laminated integrated component layer media insert of any one of claims 1, 2, 3, or 4, wherein the one or more substrate layers comprise a metal surface.   6. The laminated integrated component layer media insert of claim 5, wherein a solder film is placed on the metal surface of the one or more substrate layers.   The battery according to any one of claims 1, 2, 3, 4, 5, or 6, further comprising a battery configured to be rechargeable via at least one of radio frequency and magnetic inductance. Stacked integrated component layer media insert.   The laminated type according to any one of claims 1, 2, 3, 4, 5, 6, or 7, further comprising a thin film battery, wherein the surface of the thin film battery is configured to define a predetermined appearance. Integrated component layer media insert.   The laminated integrated component layer media insert according to any one of claims 1, 2, 3, 4, 5, 7, or 8, wherein the plurality of substrate layers are flexible.   An ophthalmic lens comprising a laminated integrated component layer media insert according to any one of claims 1 to 9 coupled therein. A method for forming a laminated integrated component layer media insert for an ophthalmic lens comprising:
And forming a plurality of substrate layers, the energy source, each of the base layer, or comprise a functional component, at least one of the plurality of base material layers but includes the energy source, at least two The base material layer has a different outer diameter , forming a plurality of base material layers;
When the laminated integrated component layer medium insert is placed in an ophthalmic lens, the base layer positioned rearward has a larger outer diameter than the base layer positioned forward and the base layer positioned forward A step of laminating the base material layers one after another so that the region defined by is overlapped at a position included in the region defined by the base material layer located behind, and assembling the plurality of base material layers into a laminating mechanism;
Forming a conductive connection between the energy source and the functional component on the plurality of substrate layers, and electrically connecting the functional component to the energy source ;
Encapsulating the stacking mechanism with a single layer of material;
Including a method.   The method of claim 11, wherein the plurality of substrate layers are assembled into an annular shape or one of a portion of an annular shape.   13. The method of claim 11 or 12, further comprising the step of adhering the plurality of substrate layers to one or more insulating layers. At least two of the base material layers have at least a part of an annular shape, and one outer diameter of the annular base material layer is smaller than another outer diameter of the other annular base material layer. 14. The method according to any one of claims 11 to 13, wherein the at least two substrate layers are disposed outside an optical zone of the ophthalmic lens when disposed in the ophthalmic lens. .   15. A method according to any one of claims 11 to 14, wherein one or more of the substrate layers comprises a metal surface.   The method of claim 15, further comprising placing a solder film on the metal surface of the one or more substrate layers. Disposing a battery on one of the substrate layers of the laminated integrated component layer media insert;
The method according to any one of claims 11 to 16, wherein the battery is chargeable via at least one of radio frequency and magnetic inductance. Disposing a thin film battery on one of the substrate layers of the laminated integrated component layer media insert;
Modifying the surface of the thin film battery to define its appearance;
The method according to any one of claims 11 to 17, further comprising:   The method according to claim 11, wherein the plurality of base material layers are flexible. Forming the laminated integrated component layer media insert of any one of claims 11-19;
Coupling the laminated integrated component layer media insert into an ophthalmic lens;
Including methods.

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