JP6293885B2 - ネコの水和レベルの向上 - Google Patents
ネコの水和レベルの向上 Download PDFInfo
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- JP6293885B2 JP6293885B2 JP2016527339A JP2016527339A JP6293885B2 JP 6293885 B2 JP6293885 B2 JP 6293885B2 JP 2016527339 A JP2016527339 A JP 2016527339A JP 2016527339 A JP2016527339 A JP 2016527339A JP 6293885 B2 JP6293885 B2 JP 6293885B2
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- Investigating Or Analysing Biological Materials (AREA)
Description
1.1 前記食事が水、及びネコにとって味がよく栄養が完全なキャットフード組成物からなり、前記食物組成物がアラキドン酸及びエイコサペンタエン酸を含み、エイコサペンタエン酸に対するアラキドン酸の比が3:1以上、例えば少なくとも5:1、例えば少なくとも10:1であり、かつ前記組成物中のアラキドン酸の量が0.05〜0.5乾燥重量%である、方法1。
1.2 前記食事が、栄養が完全なキャットフードと共に、アラキドン酸を含む有効量の栄養補助食品を含む、方法1。
1.3 前記食事が、乾燥質量において、重量比で10:1以上の、ω−6及びω−3脂肪酸を含む、方法1、1.1、または1.2。
1.4 前記組成物中の、ω−3脂肪酸に対するω−6脂肪酸の、乾燥質量での比が10:1〜20:1、例えば12:1〜18:1である、方法1.3。
1.5 前記ネコが大人のネコである、前述の方法のいずれか。
1.6 前記ネコがオスネコである、前述の方法のいずれか。
1.7 前記ネコがかかる治療を必要とする、低水和より生じるネコの疾患または状態の治療方法である前述の方法のいずれか。
1.8 前記疾患または状態が、尿路結石(膀胱結石または腎臓結石を含む)、猫特発性膀胱炎、及びFLUTDの進行から選択される、方法1.7。
1.9 前記ネコは低水和より生じる疾患または状態、例えば尿路結石(膀胱結石もしくは腎臓結石を含む)、猫特発性膀胱炎、及びFLUTDの進行から選択される疾患または状態の、進行のリスクが増加したことが特定されており、前記リスクは(a)前記ネコの尿比重により評価され、少なくとも1.05、例えば1.06より大きい、例えば1.07より大きい尿比重を有するネコはリスクが増加したと考えられ、かつ/または(b)前記ネコはリスクの増加と関係するPTGES3遺伝子内でSNPもしくは変異を発現する、方法1.7または1.8。
1.10 前記ネコが、chrB4.101464677、chrB4.101341304及びchrB4.101438741から選択される1種以上の一塩基変異多型(SNP)を提示することに基づき、リスクが増加していると特定されている、方法1.9。
1.11 前記ネコの初期尿比重が1.055より大きい、例えば1.06より大きい、前述の方法のいずれか。
1.12 前記方法の実践の1ヶ月後、例えば3ヶ月後、例えば6ヶ月後における前記ネコの尿比重が、例えば前記ネコの初期尿比重と比較して、例えば1.055未満に低下している、前述の方法のいずれか。
1.13 前記ネコがPTGES3遺伝子中に変異を有する、前述の方法のいずれか。
1.14 前記ネコが、chrB4.101464677、chrB4.101341304及びchrB4.101438741から選択される1種以上の一塩基変異多型(SNP)を示す、前述の方法のいずれか。
1.15 前記ネコが少なくとも1ヶ月、例えば少なくとも3ヶ月、例えば少なくとも6ヶ月間、前記食事を維持する、前述の方法のいずれか。
1.16 前記ネコにおける前記向上した水和が、尿比重の低下として測定される、前述の方法のいずれか。
1.17 前記ネコにおける前記向上した水和が、血液浸透圧の低下として測定される、前述の方法のいずれか。
1.18 前記方法がプロスタグランジンE2レベルの増加を引き起こす、前述の方法のいずれか。
1.19 前記方法にしたがった食事を受ける前記ネコが水分摂取の増加を示すが、塩化ナトリウム摂取の増加を示さない、前述の方法のいずれか。
1.20 前記食事を受ける前記ネコが、少なくとも2歳、例えば少なくとも5歳である、前述の方法のいずれか。
1.21 前記ネコの食事が、以下で説明する組成物1(以下参照)のいずれかを含む、前述の方法のいずれか。
を提供する。
1.1 アラキドン酸の量が0.05〜0.5乾燥重量%である、組成物1。
1.2 前記組成物が少なくとも5%、例えば少なくとも7乾燥重量%の家禽肝、例えばニワトリの肝臓、及び1乾燥重量%未満の魚油を含む、組成物1または1.1。
1.3 以下の実施例3の食事Bで説明する実質的な成分を含む、前述の組成物のいずれか(「説明する実質的な」とは、一覧表に記載されている各成分が、乾燥重量基準で説明した量の±5%、例えば±2%の量で前記組成物中に存在することを意味する)。
1.4 乾燥食物、例えばキブル製品の形態の、前述の組成物のいずれか。
1.5 方法1のいずれか(以下参照)での使用のための組成物1または1.1。
を提供する。
表1:ネコの尿比重の全ゲノム関連研究に使用したジェノタイピングアッセイの説明
表2:ネコの尿比重に関係する最も有意なSNP
表3:ネコの尿比重に関係する最も有意な3つのSNPはプロスタグランジンEシンターゼ遺伝子(PTGES3)に隣接する
表4:ネコゲノムにおけるプロスタグランジンEシンターゼ3(PTGES3)遺伝子の説明
chrB4.101464677 [T/C]
ATTTTAGAAATCTACCACCGTATGGAGGCAAGTGTAGAGGGATTCTTAGCCGAGGGTAGAAGAACTATTAGGAAATGATAGCAATAGCCTGTTCAGGTGG[T/C]TCTCAGTTAAGGCAGTGGCATTAGGAATGAAGCAATGGGGGGATAAACAGAAAATATTTAGAAAGTAAATATAGTAGGGAATGGCTATGAAGAAGTCTGT(配列番号:1)
chrB4.101341304 [A/G]
ATAAATTAAACTTCTGTCCAAGATGATGAGTGCATGCAAGAAAGCACCACTCACAAAAAAATGGGATAGGGACACCATAATGGAGTGAGGACCTTTACTC[A/G]GGCTGGGAAATCTTCCCACCCTCCAGTCTGGAAGTTTTATTTTGGTGAACCCTCTAAAGATACAAGGTACAGGAACACCAGCTTCCAGCACCATAAAAAT(配列番号:2)
chrB4.101438741 [A/G]
CAGTGGAGAGTCGAAGTTTGTGGGAATGGGGAGATGAGATGAGGACACTCCTTGTCTTCAGGCACATCATTAGGGGGAGAAGGTTACCCATCTGTTTTCA[A/G]CCATTATCTCTTGAACTGCCGCTTTGTCCCTTGAACGTGGTTGGGCTGTAATGAGGGATAGTAACCAAGAGAATGAAAACAGTACTTACTGCCTATTGTA(配列番号:3)
実施例2:EPAに対するAAの異なる比率を使用した、成熟ネコの調査
表5:高齢のネコにおける尿比重の変化
表6:成熟したネコにおいて、EPAに対するAAの高い比率が血液浸透圧を低下させる
実施例3:EPAに対するAAの異なる比率を用いた子ネコの給餌調査
表7:子ネコの尿比重の変化
実施例4
AA及びEPAと、シュウ酸カルシウムRSSとの相関関係
CORR手順
変数付き2つ:AA、EPA
1つの変数:シュウ酸カルシウムRSS
ピアソン相関係数
H0:Rho=0において、確率>|r|
観測結果の数
AA −0.44188
<.0001
97
GLMの手順
従属変数:シュウ酸カルシウムRSS
変数付き1つ:比率
1つの変数:シュウ酸カルシウムRSS
ピアソン相関係数
H0:Rho=0において、確率>|r|
観測結果の数
比率 −0.38885
<.0001
96
血液中のAAの増加はRSSの低下と関係がある一方、EPA濃度の増加はRSSの増加と関係があるという点で、有意な関係が存在する。
Claims (6)
- ネコの水和レベルを向上させることにより、治療を必要とする、低水和より生じるネコの疾患または状態を治療する方法であって、この疾患または状態は、尿路結石、猫特発性膀胱炎、及びFLUTDの進行から選択されるものであり、該方法は、前記ネコに、アラキドン酸及びエイコサペンタエン酸を含む食事を提供することを含み、エイコサペンタエン酸に対するアラキドン酸の比率は、乾燥重量基準で3:1またはこれより大きく、前記食事中のω−3脂肪酸に対するω−6脂肪酸の比率は、乾燥重量基準で10:1〜20:1未満であり、前記アラキドン酸の量が前記食事の乾燥重量の0.05〜0.5%であり、また、前記食事は、総脂肪の0.01%未満のエイコサペンタエン酸を含む前記方法。
- 前記食事は、水と、ネコにとって味がよく、栄養が完全なキャットフード組成物とからなり、前記キャットフード組成物はアラキドン酸及びエイコサペンタエン酸を含み、エイコサペンタエン酸に対するアラキドン酸の比率は、乾燥重量基準で3:1またはこれより大きく、前記組成物中のω−3脂肪酸に対するω−6脂肪酸の比率は、乾燥重量基準で10:1〜20:1未満であり、前記アラキドン酸の量が前記組成物の乾燥重量の0.05〜0.5%であり、また、前記組成物は、総脂肪の0.01%未満のエイコサペンタエン酸を含む請求項1に記載の方法。
- 前記食事が、栄養が完全なキャットフードと共に、アラキドン酸を含む有効量の栄養補助食品を含む請求項1に記載の方法。
- 前記方法の実践の1ヶ月後の、前記ネコの尿比重が、前記ネコの初期尿比重と比較して低下している請求項1〜3のいずれかに記載の方法。
- 前記ネコが前記食事を少なくとも1ヶ月間継続する請求項1〜4のいずれかに記載の方法。
- 前記食事または前記組成物が、乾燥重量で少なくとも5%の家禽肝と、乾燥重量で1%未満の魚油とを含む請求項1〜5のいずれかに記載の方法。
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US20210337830A1 (en) * | 2018-09-10 | 2021-11-04 | Mars, Incorporated | Compositions containing linoleic acid |
AU2018447678B2 (en) | 2018-11-02 | 2022-04-21 | Hill's Pet Nutrition, Inc. | Pet food compositions, method of treating an inflammatory condition and method of reducing ciculatpro-inflammatory cytokines |
CN110037167A (zh) * | 2019-01-24 | 2019-07-23 | 玫斯江苏宠物食品科技有限公司 | 一种下泌尿道护理成年期猫粮及其制备方法 |
CA3127592A1 (en) * | 2019-01-25 | 2020-07-30 | Hill's Pet Nutrition, Inc. | Methods for identifying a companion animal susceptible to treatment that reduces the risk of stone formation and compositions for reducing such risk |
US20230015727A1 (en) * | 2019-12-16 | 2023-01-19 | Hill's Pet Nutrition, Inc. | Methods, Kits and Compositions for Diagnosing and Treating Renal Disease |
CA3164205A1 (en) * | 2019-12-18 | 2021-06-24 | Hill's Pet Nutrition, Inc. | Methods for identifying a companion animal at risk of calcium oxalate stone formation and treatments and compositions for reducing the risk |
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US6946488B2 (en) | 2000-05-01 | 2005-09-20 | The Iams Company | Pet food composition for reducing inflammatory response in cats |
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US9884035B2 (en) | 2018-02-06 |
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BR112016010014A2 (pt) | 2017-12-05 |
CA3106605C (en) | 2022-09-20 |
US20160296486A1 (en) | 2016-10-13 |
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MX369318B (es) | 2019-11-05 |
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AU2013405193B2 (en) | 2017-04-20 |
RU2651472C1 (ru) | 2018-04-19 |
CA3106605A1 (en) | 2015-05-21 |
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