JP6289398B2 - applicator - Google Patents

Description

  The present invention relates to an applicator for filling a bone defect or damaged part with a paste-like bone regeneration material obtained by kneading a powder and an aqueous medium.

  Conventionally, a paste-like bone filling material in which calcium phosphate granules are suspended in an aqueous medium has been used for the treatment of bone defects or damaged parts (for example, Patent Documents 1 to 3). This paste-like bone filling material is filled in a bone defect or damage, and is cured after filling and fixed to the bone defect or damage.

  However, the above-described paste-like bone filling material merely compensates for a bone defect or damage, and does not promote bone regeneration. Indeed, bone regeneration is limited to the surface of the filled bone prosthetic material. In addition, the above paste-like bone filling material does not contain organic components such as collagen fibers of bone tissue, and therefore has a decisive disadvantage of being inferior in elastic modulus and toughness.

  Accordingly, the present inventors have developed a paste-like bone regeneration material that can compensate for the above-mentioned drawbacks. This pasty bone regeneration material can be obtained by kneading a powder and an aqueous medium. The powder contains fine particles made of calcium salt adsorbed on the surface of inositol phosphate or a salt thereof, and fine particles made of a bioabsorbable polymer. The aqueous medium is, for example, water for injection, bone marrow fluid, or cell suspension. Further, the aqueous medium contains a small amount of a water-soluble polymer for the purpose of adjusting viscosity, contains an antibacterial agent for the purpose of preventing infection, and various growth factors for the purpose of promoting bone regeneration. You may contain.

  When treating a bone defect or damaged portion with the paste-like bone regeneration material, a paste-like bone regeneration material is obtained by kneading a powder and an aqueous medium, and then the paste-like bone regeneration material is boned. It is performed to fill the defect portion or the damaged portion. When this filling is performed, continuous pores are formed by absorbing fine particles made of bioabsorbable polymer over time, and osteoblasts enter the continuous pores to regenerate the patient's own bone. Is done.

  According to the above paste-like bone regeneration material, it is possible to secure bone mechanical properties by compensating for bone defect or damage in the short term and to promote the regeneration of the patient's own bone in the long term. it can. In addition, fine particles made of calcium salt with inositol phosphate or its salt adsorbed on the surface and fine particles made of bioabsorbable polymer are used in combination, so that they can be disintegrated even after contact with moisture such as blood and body fluids after filling. Can exhibit non-disintegrating properties.

JP 2000-262609 A JP 2000-245823 A JP 2002-35106 A

  When treating bone with the above paste-like bone regenerative material, without mixing bacteria and viruses, powder and aqueous medium are kneaded, or paste-like bone regenerative material is filled into bone defects, etc. Is required.

  The present invention has been made in view of the above-described matters, and its purpose is to obtain a paste-like bone regenerating material by kneading a powder and an aqueous medium without mixing bacteria and viruses. An object of the present invention is to provide an applicator capable of filling a bone defect or damage with a regenerated material.

  The applicator according to the present invention obtains a paste-like bone regeneration material by kneading a powder and an aqueous medium, and uses the paste-like bone regeneration material to fill a bone defect or damage portion. A cylinder having a hollow cylindrical shape in which an inlet for the powder and the aqueous medium is formed on a side wall; and a plunger that is inserted into the cylinder so as to freely advance and retract from an opening at a base end of the cylinder; A hollow needle attached to the tip of the cylinder; and a kneading means for obtaining the paste-like bone regeneration material by kneading the powder and the aqueous medium introduced into the cylinder from the introduction port. A chamber having a variable volume is formed between the tip of the plunger and the tip of the cylinder by advancing and retracting the plunger, and the paste-like bone regeneration material is The hollow needle cavity communicates with the chamber, and the advancement of the plunger reduces the volume of the chamber so that the pasty bone regenerating material stored in the chamber is Released through the hollow needle.

  Preferably, the plunger is formed with a through-hole extending in the axial direction of the plunger, and the kneading means includes a shaft body inserted into the through-hole of the plunger so as to advance and retreat, and a distal end of the shaft body. A plurality of slats extending radially outward in a radial direction, the volume of the chamber is increased by retreating the plunger, and the chamber is communicated with the inlet, so that the inlet is connected to the chamber. In the state in which the powder and the aqueous medium can be charged, and the powder and the aqueous medium are charged in the chamber, the blades are positioned in the chamber by the forward operation of the shaft body, and the shaft The paste-like bone regeneration material is obtained by rotating the plurality of blades by rotating the body and kneading the powder and the aqueous medium.

  Preferably, the packing further includes a rubber packing joined to the tip of the plunger, and the outer diameter of a part or the whole of the packing matches the inner diameter of the cylinder, and the packing has a through hole of the plunger. A through hole located on the same axis and a plurality of grooves extending radially outward from the through hole are formed, and the shaft body is inserted into the through hole of the plunger and the through hole of the packing so as to freely advance and retract. The reciprocating and rotating operations of the shaft body accommodate the plurality of blade plates in the groove of the packing, and the advancement operation of the shaft body causes the plurality of blade plates to exit from the groove of the packing, Located in the chamber.

  Preferably, the plunger includes a spiral projection as the kneading means, and the spiral projection is formed in a range of the plunger inserted into the cylinder, and an upper end of the spiral projection is The powder and the aqueous medium can be introduced into the gap from the inlet by contacting the inner surface of the cylinder and communicating the gap between the spiral projections with the inlet by the advancement / retraction operation of the plunger. In the state where the powder and the aqueous medium are put into the gap, the powder and the aqueous medium are kneaded by rotating the plunger so that the powder and the aqueous medium are kneaded by the pressing by the spiral protrusions. And the paste-like bone regeneration material is sent to the chamber.

  Preferably, the packing further comprises a rubber packing joined to the tip of the plunger, and the outer diameter of a part or the whole of the packing coincides with the inner diameter of the cylinder, and is in a range of a part of the side surface of the packing. A recess is formed, and the gap between the spiral projections communicates with the chamber through the recess, and the paste-like bone regeneration material fed by the spiral projection is in the chamber through the recess. To be supplied.

  Preferably, a flange attached to the base end of the cylinder is further provided, and a pair of saliva portions projecting radially outward is formed at the base end of the cylinder, and the flange includes a plate-shaped main body portion, A pair of wall portions standing from both ends in the width direction of the main body, and a through hole is formed in the center of the main body in the width direction, and the diameter of the through hole of the main body is the outer diameter of the plunger In the state in which grooves having a shape corresponding to the pair of saliva parts are formed on the inner side surfaces of the pair of wall parts, and the flange is attached to the base end of the cylinder, the pair of wall parts The base end of the cylinder is sandwiched between the pair of saliva portions, and the plunger is engaged with the groove of the pair of wall portions, and the plunger is connected to the through hole of the main body portion and the base end of the cylinder. Through the opening of the cylinder and inserted into the cylinder. It is.

  According to the applicator of the present invention, the powder and the aqueous medium are kneaded in the cylinder. For this reason, it is possible to obtain a paste-like bone regeneration material in an aseptic state by kneading the powder and the aqueous medium without mixing bacteria and viruses. Then, after obtaining the paste-like bone regeneration material in the cylinder as described above, the plunger is advanced so that the paste-like bone regeneration material is not exposed to the outside air via the hollow needle. Or it can fill the damaged part. Therefore, the paste-like bone regeneration material can be filled in the bone defect or damage without mixing bacteria and viruses. The hollow needle may have a shape with a sharp tip, a cylindrical shape with a constant inner diameter and an outer diameter, a brush shape with a flat tip, or a bent shape.

It is a perspective view which shows the applicator which concerns on 1st Embodiment of this invention. It is a perspective view showing some applicators concerning a 1st embodiment. It is a perspective view showing some applicators concerning a 1st embodiment. It is a perspective view which shows the procedure which fills the defect | deletion part or damaged part of a bone with the paste-form bone regeneration material using the applicator which concerns on 1st Embodiment. It is a perspective view which shows the procedure which fills the defect | deletion part or damaged part of a bone with the paste-form bone regeneration material using the applicator which concerns on 1st Embodiment. It is a perspective view which shows the applicator which concerns on 2nd Embodiment of this invention. It is a figure which shows the procedure which fills the defect | deletion part or damaged part of a bone with the paste-form bone regeneration material using the applicator of 2nd Embodiment.

  Embodiments of the present invention will be described below with reference to the drawings. FIG. 1 is a perspective view showing an applicator 1 according to the first embodiment of the present invention. 2 and 3 are perspective views showing a part of the applicator 1 according to the first embodiment. FIG. 2 shows a cylinder 2 described later, and FIG. 3 shows a plunger 3 and a kneading means 5 described later. FIG. 4 and FIG. 5 are perspective views showing a procedure for filling the bone defect or damaged part with the paste-like bone regeneration material P using the applicator 1 according to the first embodiment.

  The applicator 1 according to the first embodiment obtains a paste-like bone regeneration material P by kneading the powder H and the aqueous medium B, and fills the bone defect or damage with the paste-like bone regeneration material P. Used for. As described above, the powder H includes fine particles made of calcium salt having inositol phosphate or a salt thereof adsorbed on the surface and fine particles made of a bioabsorbable polymer. The aqueous medium B is, for example, water for injection, bone marrow fluid, or cell suspension. Further, the aqueous medium contains a small amount of a water-soluble polymer for the purpose of adjusting viscosity, contains an antibacterial agent for the purpose of preventing infection, and various growth factors for the purpose of promoting bone regeneration. You may contain.

  As shown in FIG. 1, the applicator 1 of the first embodiment includes a cylinder 2, a plunger 3, a hollow needle 4, and a kneading means 5. The cylinder 2 and the plunger 3 are made of a transparent material such as plastic, acrylic, or glass.

  The cylinder 2 has a hollow cylindrical shape and includes an opening 6 (FIG. 2) at the proximal end. An inlet 7 is formed in the side wall of the cylinder 2. The charging port 7 is used for charging the powder H and the aqueous medium B into the cylinder 2.

  The plunger 3 is inserted into the cylinder 2 through the opening 6 at the base end of the cylinder 2 so as to freely advance and retract. The plunger 3 is formed with a through hole 10 (FIG. 3) extending in the axial direction of the plunger 3.

  The proximal end side of the plunger 3 extends out of the cylinder 2. The user can move the plunger 3 forward and backward by gripping the proximal end side of the plunger 3.

  A flange 9 is attached to the base end of the cylinder 2. As shown in FIG. 3, a through hole 32 is formed in the flange 9, and when the plunger 3 is passed through the through hole 32, the advance and retreat of the plunger 3 is guided. The detailed structure of the flange 9 will be described later.

  A chamber 20 is formed between the tip of the plunger 3 (corresponding to a packing 11 described later) inside the cylinder 2 and the tip of the cylinder 2 (FIGS. 1, 4 and 5). The volume of the chamber 20 is variable by the advance / retreat operation of the plunger 3.

  A rubber packing 11 is joined to the tip of the plunger 3. The packing 11 has a shape in which the proximal end portion 12 and the distal end portion 13 are thick and the central portion 14 is thin. The outer diameters of the proximal end portion 12 and the distal end portion 13 of the packing 11 coincide with the inner diameter of the cylinder 2.

  As shown in FIG. 3, a through hole 15 and a plurality of grooves 16 are formed in the packing 11 (FIG. 3 shows an example in which four grooves 16 are formed). The through hole 15 of the packing 11 is positioned coaxially with the through hole 10 of the plunger 3.

  The plurality of grooves 16 extend radially outward from the through hole 15 in the radial direction. These grooves 16 are recessed from the distal end side of the packing 11, and the grooves 16 are not formed in the base end portion 12 of the packing 11 (the groove 16 is formed only in the distal end portion 13 and the central portion 14 of the packing 11. Formed). For this reason, the entire periphery of the base end portion 12 of the packing 11 is in sliding contact with the inner surface of the cylinder 2. As for the front-end | tip part 13 of the packing 11, the range in which the groove | channel 16 is not formed contacts the inner surface of the cylinder 2 slidably.

  The kneading means 5 is provided in order to obtain the paste-like bone regeneration material P by kneading the powder H and the aqueous medium B introduced into the cylinder 2. As shown in FIG. 3, the kneading means 5 includes a shaft body 21 and a plurality of blade plates 22. The shaft body 21 and the blade plate 22 are made of a metal such as stainless steel or aluminum.

  The shaft body 21 is inserted into the through hole 10 of the plunger 3 and the through hole 15 of the packing 11 so as to advance and retreat and rotate freely. The base end side of the shaft body 21 extends to the outside of the plunger 3. A handle 23 is provided at the proximal end of the shaft body 21. The user can move the shaft 21 forward and backward by rotating the handle 23.

  The plurality of blades 22 extend radially from the tip end of the shaft body 21 radially outward. The user can accommodate the blade 22 in the groove 16 of the packing 11 by retracting the shaft body 21. Further, the user can advance the shaft body 21 so that the blade plate 22 comes out of the groove 16 and is positioned in the chamber 20 (FIG. 4C). As shown in FIG. 4C, in a state where the blade plate 22 is positioned in the chamber 20, the user can rotate the blade plate 22 by holding the handle 23 and rotating the shaft body 21.

  As shown in FIG. 1, the hollow needle 4 is attached to the tip of the cylinder 2. A cavity (not shown) of the hollow needle 4 communicates with the chamber 20. The hollow needle 4 is made of, for example, stainless steel or plastic.

  When the paste-like bone regeneration material P is filled into a bone defect or damage using the applicator 1 described above, first, as shown in FIG. The volume of 20 is increased and the chamber 20 is communicated with the inlet 7.

  Next, the powder H and the aqueous medium B are charged into the chamber 20 from the charging port 7 (FIG. 4A).

  Next, as shown in FIG. 4B, the chamber 20 is not communicated with the inlet 7 by reducing the volume of the chamber 20 by the forward operation of the plunger 3. This operation is performed in order to prevent the powder H and the aqueous medium B in the chamber 20 from leaking from the inlet 7. For example, when there is no possibility that the powder H and the aqueous medium B leak from the inlet 7 by making the inlet 7 upward, the operation of FIG. 4B can be omitted.

  Next, as shown in FIG. 4C, the plurality of blades 22 are extracted from the grooves 16 (FIG. 3) of the packing 11 and positioned in the chamber 20 by the forward operation of the shaft body 21.

  Next, the powder H and the aqueous medium B are kneaded by rotating the blades 22 by rotating the shaft body 21 (FIG. 4C). Thereby, the paste-like bone regeneration material P is obtained, and the paste-like bone regeneration material P is stored in the chamber 20. After the kneading is completed, as shown in FIG. 5A, the plurality of blade plates 22 are accommodated in the grooves 16 (FIG. 3) of the packing 11 by retreating and rotating the shaft body 21.

  Next, the tip of the hollow needle 4 is positioned at a bone defect or damage.

  Next, as shown in FIG. 5B, the volume of the chamber 20 is reduced by the forward operation of the plunger 3, thereby releasing the pasty bone regenerating material P stored in the chamber 20 through the hollow needle 4. . As a result, the paste-like bone regeneration material P is filled into the bone defect or damage.

  According to the first embodiment, the powder H and the aqueous medium B are kneaded in the cylinder 2. Therefore, the paste H bone regenerating material P in an aseptic state can be obtained by kneading the powder H and the aqueous medium B without mixing bacteria and viruses. Then, after obtaining the paste-like bone regeneration material P by the above-mentioned kneading, the plunger 3 is moved forward (FIG. 5B), so that the paste-like bone regeneration material P does not touch the outside air and the bone is lost. It is possible to fill a part or a damaged part. Therefore, the paste-like bone regeneration material P can be filled in the bone defect or damage without mixing bacteria and viruses.

  Moreover, the powder H and the aqueous medium B can be reliably kneaded by sufficiently stirring with the blade plate 22 (FIG. 4C).

  Further, as shown in FIG. 5 (a), after the blade plate 22 is accommodated in the groove 16 (FIG. 3) by the backward operation of the shaft body 21, the forward operation of the plunger 3 is performed as shown in FIG. 5 (b). By performing the above, the plunger 3 can be brought close to the tip of the cylinder 2 without being obstructed by the blade 22. As a result, all of the pasty bone regeneration material P in the chamber 20 can be filled in the bone defect or damage.

  In addition, the packing 11 attached to the distal end of the plunger 3 is in sliding contact with the inner surface of the cylinder 2, so that the powder H, the aqueous medium B, and the pasty bone regeneration material P stored in the chamber 20 are moved to the proximal end side of the cylinder 2. Backflow can be prevented.

  Further, the packing 11 has a base end portion 12 and a tip end portion 13 that are thick and a center portion 14 has a thin shape, so that only the base end portion 12 and the tip end portion 13 of the packing 11 are brought into sliding contact with the inner surface of the cylinder 2. The center portion 14 of the packing 11 can be prevented from slidingly contacting the inner surface of the cylinder 2. Thereby, since the frictional force between the packing 11 and the cylinder 2 becomes small, the plunger 3 can be smoothly advanced and retracted.

  The entire outer diameter of the packing 11 may match the inner diameter of the cylinder 2. In this case, since the area of the packing 11 slidably contacting the inner surface of the cylinder 2 is increased, it is possible to reliably prevent the powder H, the aqueous medium B, and the pasty bone regeneration material P from flowing backward to the proximal end side of the cylinder 2. .

  Further, in the applicator 1 of the first embodiment, the maximum volume of the chamber 20 can be increased by increasing the volume of the cylinder 2 or forming the input port 7 on the base end side of the cylinder 2. Then, by taking measures to increase the maximum volume of the chamber 20 in this way, a large amount of the powder H and the aqueous medium B can be charged into the cylinder 2. Therefore, many pasty bone regeneration materials P can be obtained.

  Next, the flange 9 attached to the proximal end of the cylinder 2 will be described.

  As shown in FIG. 3, the flange 9 includes a plate-shaped main body 30 and a pair of wall portions 31, 31 that rise from both ends of the main body 30 in the width direction.

  A through hole 32 is formed in the center of the main body 30 in the width direction. The diameter of the through hole 32 coincides with the outer diameter of the plunger 3, and the plunger 3 is passed through the through hole 32.

  Grooves 33 and 33 are formed on the inner side surfaces of the pair of wall portions 31 and 31, respectively. As shown in FIG. 2, a pair of saliva portions 8, 8 projecting radially outward is formed at the proximal end of the cylinder 2. The saliva parts 8 and 8 are used for attaching the flange 9 to the base end of the cylinder 2, and the grooves 33 and 33 of the wall parts 31 and 31 correspond to the saliva parts 8 and 8 (FIG. 2). Presents a shape

  When attaching the flange 9 to the base end of the cylinder 2, first, the base end side of the plunger 3 is passed through the through hole 32 of the flange 9. Next, the distal end side of the plunger 3 is inserted into the cylinder 2 through the opening 6 at the proximal end of the cylinder 2. Next, the flange 9 is slid along the outer surface of the plunger 3, the flange 9 is brought close to the base end of the cylinder 2, and the base end of the cylinder 2 is positioned between the pair of wall portions 31 and 31. At this time, the saliva parts 8 and 8 of the cylinder 2 are in a state of extending from between the wall parts 31 and 31. Next, by rotating the flange 9 relative to the cylinder 2 around one side in the circumferential direction of the cylinder 2, the saliva portion 8 enters the groove 33 from the opening at one end of the groove 33, The part 8 is engaged with the groove 33.

  A detent 35 (FIG. 3) is formed at the other end of the groove 33. When the above relative rotation is performed until the saliva portion 8 abuts against the detent 35, the flange 9 is connected to the cylinder 2. It will be in the state attached to the base end of. In this state, the base end of the cylinder 2 is sandwiched between the pair of wall portions 31, 31, the full width of the saliva portions 8, 8 is engaged with the grooves 33, 33, and the plunger 3 is connected to the flange 9. Is inserted into the cylinder 2 through the through-hole 32 (FIG. 3) and the opening 6 (FIG. 2) of the cylinder 2.

  Then, when the plunger 3 is advanced and retracted with the flange 9 attached to the base end of the cylinder 2 as described above (FIGS. 4A, 4B, 5A and 5A), FIG. 5 (b)), the forward and backward movement of the plunger 3 is guided by the outer surface of the plunger 3 being in sliding contact with the wall surface of the through hole 32 of the flange 9. Therefore, the forward / backward operation of the plunger 3 can be performed smoothly.

  Next, an applicator 40 according to a second embodiment of the present invention will be described. FIG. 6 is a perspective view showing an applicator 40 according to the second embodiment of the present invention. FIG. 7 is a diagram showing a procedure for filling the bone defect or damaged part with the paste-like bone regeneration material P using the applicator 40 according to the second embodiment.

  The applicator 40 of the second embodiment also obtains the paste-like bone regeneration material P by kneading the powder H and the aqueous medium B, and fills the bone defect or damage with the paste-like bone regeneration material P. used. In the applicator 40 of the second embodiment, a kneading means (a helical projection 70 described later) for mixing the powder H and the aqueous medium B is provided on the plunger 42 described later.

  As shown in FIG. 6, the applicator 40 of the second embodiment includes a cylinder 41, a plunger 42, and a hollow needle 43. The cylinder 41 and the plunger 42 are made of a transparent material such as plastic, acrylic, or glass.

  The cylinder 41 has a hollow cylindrical shape and includes an opening (not shown) at the proximal end. An input port 50 is formed in the side wall of the cylinder 41. The charging port 50 is used for charging the powder H and the aqueous medium B into the cylinder 41.

  The plunger 42 is inserted into the inside of the cylinder 41 through an opening at the base end of the cylinder 41 so as to freely advance and retract. The proximal end side of the plunger 42 extends outside the cylinder 41. The user can move the plunger 42 forward and backward or rotate by gripping the proximal end side of the plunger 42.

  Inside the opening of the base end of the cylinder 41, a rubber packing 51 is disposed. In addition, a pair of saliva portions 52 and 52 projecting radially outward is formed on the outer surface of the base end of the cylinder 41, and a flange 60 is formed at the base end of the cylinder 41 using the saliva portions 52 and 52. It is attached. A through hole (not shown) is formed in each of the packing 51 and the flange 60. The through hole of the packing 51 and the through hole of the flange 60 are located on the same axis, and the plunger 42 is passed through these through holes to guide the advancement and retreat of the plunger 42. Further, the outer peripheral surface of the packing 51 is in sliding contact with the inner peripheral surface of the cylinder 41 and the outer peripheral surface of the plunger 42 is in sliding contact with the wall surface of the through hole of the packing 51 so that liquid leakage from the cylinder 41 is prevented. It has become. Said saliva parts 52 and 52 and the flange 60 have the same structure as the saliva parts 8 and 8 and the flange 9 of 1st Embodiment. For this reason, the description about the structure of the saliva parts 52 and 52 and the flange 60 is abbreviate | omitted.

  The plunger 42 is formed with a spiral projection 70 as kneading means. The spiral projection 70 is formed in the range of the plunger 42 inserted into the cylinder 41. The upper end of the spiral protrusion 70 is in contact with the inner surface of the cylinder 41.

  Inside the cylinder 41, a chamber 72 is formed between the tip of the plunger 42 (corresponding to a packing 71 described later) and the tip of the cylinder 41. The volume of the chamber 72 is variable by the advance / retreat operation of the plunger 42.

  A rubber packing 71 is joined to the tip of the plunger 42. The packing 71 has a shape in which the proximal end 73 and the distal end 74 are thick and the central portion 75 is thin. The outer diameters of the proximal end portion 73 and the distal end portion 74 of the packing 71 coincide with the inner diameter of the cylinder 41. A recess 80 is formed in a part of the side surface of the packing 71. The recess 80 extends over the entire length of the packing 71 (extends from the proximal end to the distal end of the packing 71). Through this recess 80, the gap 90 between the spiral projections 70 and the chamber 72 communicate with each other.

  The hollow needle 43 is attached to the tip of the cylinder 41. A cavity (not shown) of the hollow needle 43 communicates with the chamber 72. The hollow needle 43 is made of, for example, stainless steel or plastic.

  When the paste-like bone regeneration material P is filled into a bone defect or damage using the applicator 40 described above, first, as shown in FIG. A gap 90 between the protrusions 70 is communicated with the charging port 50. FIG. 7A shows a state in which the plunger 42 is retracted to a position where the proximal end of the spiral protrusion 70 contacts the packing 51, and a gap 90 near the proximal end of the spiral protrusion 70 is formed in the insertion port 50. Communicate.

  Next, the powder H and the aqueous medium B are charged into the gap 90 from the charging port 50 (FIG. 7A).

  Next, as shown in FIG. 7B, the helical protrusion 70 is rotated by the rotation operation of the plunger 42. According to this rotation operation, the powder H and the aqueous medium B are kneaded by pressing by the spiral protrusion 70 to obtain the paste-like bone regeneration material P, and the paste-like bone regeneration material P is directed toward the chamber 72. Sent. Then, the paste-like bone regeneration material P is put into the chamber 72 through the recess 80 and stored in the chamber 72.

  Next, the tip of the hollow needle 43 is positioned at a bone defect or damage.

  Next, as shown in FIG. 7C, the volume of the chamber 72 is reduced by the forward operation of the plunger 42, so that the pasty bone regenerating material P stored in the chamber 72 is released through the hollow needle 43. . As a result, the paste-like bone regeneration material P is filled into the bone defect or damage.

  According to the second embodiment, the powder H and the aqueous medium B are kneaded in the cylinder 41. Therefore, the paste H bone regenerating material P in an aseptic state can be obtained by kneading the powder H and the aqueous medium B without mixing bacteria and viruses. Then, after obtaining the paste-like bone regeneration material P by the above-mentioned kneading, the plunger 42 is advanced (FIG. 7 (c)), so that the paste-like bone regeneration material P does not touch the outside air and the bone is lost. It is possible to fill a part or a damaged part. Therefore, the paste-like bone regeneration material P can be filled in the bone defect or damage without mixing bacteria and viruses.

  Further, the powder H and the aqueous medium B can be kneaded by a simple operation of rotating the plunger 42 (FIG. 7B).

  Further, since the helical projection 70 as the kneading means is provided on the plunger 42, it is not necessary to provide a kneading means separate from the plunger 42. For this reason, the number of parts can be reduced. In addition, unlike the shaft body 21 of the first embodiment, there is no part extending from the base end side of the plunger 42, so that the base end side of the plunger 42 can be easily gripped. Therefore, the advance / retreat operation and the rotation operation of the plunger 42 can be easily performed.

  In addition, the packing 11 attached to the distal end of the plunger 3 is in sliding contact with the inner surface of the cylinder 2, whereby the pasty bone regenerating material P stored in the chamber 72 can be prevented from flowing backward to the proximal end side of the cylinder 41.

  Further, the packing 71 has a base end portion 73 and a tip end portion 74 that are thick and a center portion 75 has a thin shape, so that only the base end portion 73 and the tip end portion 74 of the packing 71 are brought into sliding contact with the inner surface of the cylinder 41. The center portion 75 of the packing 71 can be prevented from slidingly contacting the inner surface of the cylinder 41. Thereby, since the frictional force between the packing 71 and the cylinder 41 becomes small, the plunger 42 can be advanced and retracted smoothly.

  Note that the entire outer diameter of the packing 71 may match the inner diameter of the cylinder 41. In this case, since the area of the packing 71 slidably contacting the inner surface of the cylinder 41 is increased, it is possible to reliably prevent the pasty bone regeneration material P from flowing backward to the proximal end side of the cylinder 41.

DESCRIPTION OF SYMBOLS 1,40 Applicator 2,41 Cylinder 3,42 Plunger 4,43 Hollow needle 5,70 Kneading means 6 Cylinder base end opening 7,50 Inlet 8,52 Saliva 9,60 Flange 10 Plunger through hole 11 , 71 Packing 15 Packing through-hole 16 Packing groove 20, 72 Chamber 21 Shaft 22 Blade plate 30 Flange body 31 Flange wall 32 Body through-hole 33 Wall groove 70 Helical projection 80 Packing projection 80 Recess 90 Gap between spiral protrusions H Powder B Water-based medium P Paste-like bone regeneration material

Claims (3)

It is an applicator used for kneading a powder and an aqueous medium to obtain a paste-like bone regeneration material and filling the paste-like bone regeneration material into a bone defect or damaged part,
A cylinder having a hollow cylindrical shape, and a dust port and an inlet for the aqueous medium formed on a side wall;
A plunger that is inserted into the inside of the cylinder so as to freely advance and retract from an opening at the base end of the cylinder;
A hollow needle attached to the tip of the cylinder;
Kneading means for obtaining the paste-like bone regeneration material by kneading the powder and the aqueous medium introduced into the cylinder from the inlet,
Between the distal end of the plunger and the distal end of the cylinder, a chamber whose volume is variable by an advance / retreat operation of the plunger is formed, and the paste-like bone regeneration material is stored in the chamber,
A cavity of the hollow needle communicates with the chamber;
By reducing the volume of the chamber by the advance operation of the plunger, the pasty bone regeneration material stored in the chamber is released through the hollow needle ,
The plunger is provided with a spiral projection as the kneading means,
The spiral protrusion is formed in a range of the plunger inserted into the cylinder,
The upper end of the spiral protrusion is in contact with the inner surface of the cylinder,
By allowing the space between the spiral projections to communicate with the charging port by the advance / retreat operation of the plunger, the powder and the aqueous medium can be charged into the space from the charging port.
In a state where the powder and the aqueous medium are put into the gap, the powder and the aqueous medium are kneaded by rotating the plunger so that the powder and the aqueous medium are kneaded to obtain the pasty bone regeneration material. And an applicator through which the pasty bone regeneration material is directed towards the chamber . The rubber packing further joined to the tip of the plunger,
The outer diameter of a part or the whole of the packing corresponds to the inner diameter of the cylinder,
A recess is formed in a part of the side surface of the packing, and the space between the spiral protrusion and the chamber communicate with each other through the recess.
The applicator according to claim 1 , wherein the paste-like bone regeneration material fed by the spiral protrusion is supplied to the chamber through the recess. A flange attached to the base end of the cylinder;
At the base end of the cylinder, a pair of saliva portions protruding radially outward is formed,
The flange includes a plate-shaped main body portion and a pair of wall portions standing from both ends in the width direction of the main body portion,
A through hole is formed in the center of the main body in the width direction,
The diameter of the through hole of the main body matches the outer diameter of the plunger,
A groove having a shape corresponding to the pair of saliva portions is formed on the inner side surfaces of the pair of wall portions,
In a state where the flange is attached to the base end of the cylinder, the base end of the cylinder is sandwiched between the pair of wall portions, and the pair of saliva portions engages with the grooves of the pair of wall portions. together and said plunger, said through an opening of the through hole and the base end of the cylinder of the main body, applicator according to claim 1 or 2 is inserted inside the cylinder.