JP6277495B2 - 野外にて脳卒中犠牲者の治療を開始し監視するための可搬式デバイス - Google Patents
野外にて脳卒中犠牲者の治療を開始し監視するための可搬式デバイス Download PDFInfo
- Publication number
- JP6277495B2 JP6277495B2 JP2015511790A JP2015511790A JP6277495B2 JP 6277495 B2 JP6277495 B2 JP 6277495B2 JP 2015511790 A JP2015511790 A JP 2015511790A JP 2015511790 A JP2015511790 A JP 2015511790A JP 6277495 B2 JP6277495 B2 JP 6277495B2
- Authority
- JP
- Japan
- Prior art keywords
- ultrasonic
- power
- ultrasonic transducer
- cavitation
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Clinical applications
- A61B8/0808—Clinical applications for diagnosis of the brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22005—Effects, e.g. on tissue
- A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
- A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/01—Constructive details
- A61H2201/0173—Means for preventing injuries
- A61H2201/0176—By stopping operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/01—Constructive details
- A61H2201/0173—Means for preventing injuries
- A61H2201/018—By limiting the applied torque or force
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/10—Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy
- A61H2201/105—Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy with means for delivering media, e.g. drugs or cosmetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/16—Physical interface with patient
- A61H2201/1602—Physical interface with patient kind of interface, e.g. head rest, knee support or lumbar support
- A61H2201/1604—Head
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/50—Control means thereof
- A61H2201/5002—Means for controlling a set of similar massage devices acting in sequence at different locations on a patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/50—Control means thereof
- A61H2201/5005—Control means thereof for controlling frequency distribution, modulation or interference of a driving signal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/50—Control means thereof
- A61H2201/5023—Interfaces to the user
- A61H2201/5043—Displays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/50—Control means thereof
- A61H2201/5058—Sensors or detectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/50—Control means thereof
- A61H2201/5097—Control means thereof wireless
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2205/00—Devices for specific parts of the body
- A61H2205/02—Head
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
- A61H23/02—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
- A61H23/0245—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive with ultrasonic transducers, e.g. piezoelectric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0039—Ultrasound therapy using microbubbles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0052—Ultrasound therapy using the same transducer for therapy and imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0078—Ultrasound therapy with multiple treatment transducers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261646106P | 2012-05-11 | 2012-05-11 | |
| US61/646,106 | 2012-05-11 | ||
| US201261681025P | 2012-08-08 | 2012-08-08 | |
| US61/681,025 | 2012-08-08 | ||
| PCT/US2013/040664 WO2013170223A1 (en) | 2012-05-11 | 2013-05-10 | Portable device to initiate and monitor treatment of stroke victims in the field |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517350A JP2015517350A (ja) | 2015-06-22 |
| JP2015517350A5 JP2015517350A5 (https=) | 2016-06-30 |
| JP6277495B2 true JP6277495B2 (ja) | 2018-02-14 |
Family
ID=49551321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511790A Active JP6277495B2 (ja) | 2012-05-11 | 2013-05-10 | 野外にて脳卒中犠牲者の治療を開始し監視するための可搬式デバイス |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9457201B2 (https=) |
| EP (1) | EP2852436A4 (https=) |
| JP (1) | JP6277495B2 (https=) |
| CN (1) | CN104363959A (https=) |
| AU (1) | AU2013259194B2 (https=) |
| CA (1) | CA2872934A1 (https=) |
| HK (1) | HK1205025A1 (https=) |
| WO (1) | WO2013170223A1 (https=) |
Families Citing this family (27)
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| US7520860B2 (en) | 2005-04-13 | 2009-04-21 | Marie G. Johnson | Detection of coronary artery disease using an electronic stethoscope |
| EP2903688A4 (en) | 2012-10-05 | 2016-06-15 | Univ Michigan | BLADE-INDUCED COLOR DOPPLER FEEDBACK DURING A HISTOTRIPSIA |
| WO2015003154A1 (en) | 2013-07-03 | 2015-01-08 | Histosonics, Inc. | Articulating arm limiter for cavitational ultrasound therapy system |
| US10780298B2 (en) | 2013-08-22 | 2020-09-22 | The Regents Of The University Of Michigan | Histotripsy using very short monopolar ultrasound pulses |
| CN104887266B (zh) * | 2015-05-29 | 2017-04-26 | 西安交通大学 | 基于面阵的小区域三维被动空化成像及三维复合成像方法 |
| WO2016210133A1 (en) | 2015-06-24 | 2016-12-29 | The Regents Of The Universtiy Of Michigan | Histotripsy therapy systems and methods for the treatment of brain tissue |
| JPWO2017126037A1 (ja) * | 2016-01-19 | 2018-08-09 | オリンパス株式会社 | 超音波医療装置 |
| EP3525883A4 (en) * | 2016-10-16 | 2020-12-02 | Vibrato Medical, Inc. | EXTRACORPORAL THERAPEUTIC ULTRASOUND TO PROMOTE ANGIOGENESIS |
| WO2018176005A1 (en) | 2017-03-24 | 2018-09-27 | BURL Concepts, Inc. | Portable ultrasound device |
| CN110691628A (zh) * | 2017-03-30 | 2020-01-14 | 国立大学法人东北大学 | 治疗痴呆的装置、操作该装置的方法和程序 |
| US10780296B2 (en) | 2017-09-01 | 2020-09-22 | Reni-Zoe Zivin | Transcranial laser therapy for treatment of acute ischemic stroke |
| WO2019183623A1 (en) * | 2018-03-23 | 2019-09-26 | Adenocyte Llc | Method to induce exfoliation of cells and/or tissue fragments for enhanced cytopathologic cell collection |
| WO2019204639A1 (en) * | 2018-04-18 | 2019-10-24 | Vibrato Medical, Inc. | Extracorporeal therapeutic ultrasound for promoting angiogenesis |
| JP2022510654A (ja) | 2018-11-28 | 2022-01-27 | ヒストソニックス,インコーポレーテッド | 組織破砕システムおよび方法 |
| US11596380B2 (en) | 2019-02-15 | 2023-03-07 | Novasignal Corp. | Categorization of waveform morphologies |
| CA3169465A1 (en) | 2020-01-28 | 2021-08-05 | The Regents Of The University Of Michigan | Systems and methods for histotripsy immunosensitization |
| FR3108853B1 (fr) * | 2020-04-01 | 2023-12-29 | Sadik Jean Claude | Rupture sélective et réversible de la barrière hémato-encéphalique par émission d’ultrasons |
| BR112022025722A2 (pt) | 2020-06-18 | 2023-03-07 | Histosonics Inc | Sistemas e métodos de acoplamento acústico e paciente de histotripsia |
| WO2022032283A2 (en) * | 2020-08-07 | 2022-02-10 | Alpheus Medical, Inc. | Ultrasound arrays for enhanced sonodynamic therapy for treating cancer |
| CA3190517A1 (en) | 2020-08-27 | 2022-03-03 | Timothy Lewis HALL | Ultrasound transducer with transmit-receive capability for histotripsy |
| US20220088345A1 (en) * | 2020-09-20 | 2022-03-24 | Apex Neuro Holdings, Inc. | Devices and methods for using mechanical affective touch therapy to reduce stress, anxiety and depression |
| WO2022216745A1 (en) * | 2021-04-05 | 2022-10-13 | Ellington Enterprises, LLC | Ultrasound therapy system and devices |
| IL308943A (en) | 2021-06-07 | 2024-01-01 | Univ Michigan Regents | All-inclusive ultrasound systems and methods that include histotripsy |
| WO2022260746A1 (en) | 2021-06-07 | 2022-12-15 | The Regents Of The University Of Michigan | Minimally invasive histotripsy systems and methods |
| US20230293193A1 (en) * | 2022-03-17 | 2023-09-21 | Open Water Internet Inc. | Clotlysis from ultrasonic harmonic excitation |
| EP4608504A1 (en) | 2022-10-28 | 2025-09-03 | Histosonics, Inc. | Histotripsy systems and methods |
| KR20260003742A (ko) | 2023-04-20 | 2026-01-07 | 히스토소닉스, 인크. | 치료 계획 및 요법을 위한 사용자 인터페이스들 및 작업 흐름들을 포함하는 히스토트립시 시스템들 및 연관된 방법들 |
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| GB9126082D0 (en) * | 1991-12-06 | 1992-02-05 | Nat Res Dev | Acoustic non-destructive testing |
| WO1993012742A1 (fr) * | 1991-12-20 | 1993-07-08 | Technomed International | Appareil de therapie par ultrasons emettant des ondes ultrasoniques produisant des effets thermiques et des effets de cavitation |
| US6196972B1 (en) * | 1998-11-11 | 2001-03-06 | Spentech, Inc. | Doppler ultrasound method and apparatus for monitoring blood flow |
| US6398772B1 (en) * | 1999-03-26 | 2002-06-04 | Coraje, Inc. | Method and apparatus for emergency treatment of patients experiencing a thrombotic vascular occlusion |
| US6682483B1 (en) * | 1999-05-28 | 2004-01-27 | Vuesonix Sensors, Inc. | Device and method for mapping and tracking blood flow and determining parameters of blood flow |
| US6887199B2 (en) * | 1999-09-23 | 2005-05-03 | Active Signal Technologies, Inc. | Brain assessment monitor |
| US7300414B1 (en) | 1999-11-01 | 2007-11-27 | University Of Cincinnati | Transcranial ultrasound thrombolysis system and method of treating a stroke |
| US7037267B1 (en) * | 1999-11-10 | 2006-05-02 | David Lipson | Medical diagnostic methods, systems, and related equipment |
| US6635017B1 (en) * | 2000-02-09 | 2003-10-21 | Spentech, Inc. | Method and apparatus combining diagnostic ultrasound with therapeutic ultrasound to enhance thrombolysis |
| US6468219B1 (en) * | 2000-04-24 | 2002-10-22 | Philip Chidi Njemanze | Implantable telemetric transcranial doppler device |
| AU2001285238A1 (en) * | 2000-08-24 | 2002-03-04 | Timi 3 Systems, Inc. | Ultrasonic system for enhancing blood perfusion |
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| CA2535981C (en) * | 2003-09-08 | 2014-10-28 | Board Of Trustees Of The University Of Arkansas | Ultrasound apparatus and method for augmented clot lysis |
| US7896821B1 (en) * | 2003-11-14 | 2011-03-01 | Perfusion Technology, LLC | Low intensity directed ultrasound (LODUS) mediated blood brain barrier disruption |
| EP1774920A4 (en) * | 2004-06-21 | 2011-01-05 | Hiroshi Furuhata | ULTRASONIC DEVICE FOR THE TREATMENT OF BRAIN INFARCT |
| CN100389890C (zh) * | 2005-02-07 | 2008-05-28 | 北京大学 | 换能器和阵及其制备方法 |
| WO2007021958A2 (en) * | 2005-08-12 | 2007-02-22 | University Of Washington | Method and apparatus for preparing organs and tissues for laparoscopic surgery |
| US20070083120A1 (en) * | 2005-09-22 | 2007-04-12 | Cain Charles A | Pulsed cavitational ultrasound therapy |
| US8257338B2 (en) * | 2006-10-27 | 2012-09-04 | Artenga, Inc. | Medical microbubble generation |
| WO2007058668A1 (en) * | 2005-11-18 | 2007-05-24 | Imarx Therapeutics, Inc. | Ultrasound apparatus and method to treat an ischemic stroke |
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| CN101500650B (zh) * | 2006-08-11 | 2012-08-08 | 皇家飞利浦电子股份有限公司 | 用于颅脑血流成像和微泡加强血块溶解的超声系统 |
| WO2008062342A2 (en) * | 2006-11-20 | 2008-05-29 | Koninklijke Philips Electronics, N.V. | Control and display of ultrasonic microbubble cavitation |
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| CN201408266Y (zh) * | 2009-04-30 | 2010-02-17 | 中国船舶重工集团公司第七一五研究所 | 一种超声测距探头 |
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| US20110112394A1 (en) | 2009-11-11 | 2011-05-12 | Mishelevich David J | Neuromodulation of deep-brain targets using focused ultrasound |
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-
2013
- 2013-05-10 CN CN201380031480.1A patent/CN104363959A/zh active Pending
- 2013-05-10 CA CA2872934A patent/CA2872934A1/en not_active Abandoned
- 2013-05-10 JP JP2015511790A patent/JP6277495B2/ja active Active
- 2013-05-10 WO PCT/US2013/040664 patent/WO2013170223A1/en not_active Ceased
- 2013-05-10 US US13/892,187 patent/US9457201B2/en active Active
- 2013-05-10 HK HK15105391.7A patent/HK1205025A1/xx unknown
- 2013-05-10 AU AU2013259194A patent/AU2013259194B2/en active Active
- 2013-05-10 EP EP13787955.7A patent/EP2852436A4/en not_active Withdrawn
-
2016
- 2016-08-31 US US15/253,118 patent/US20160367839A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20160367839A1 (en) | 2016-12-22 |
| US20140155788A1 (en) | 2014-06-05 |
| EP2852436A4 (en) | 2015-08-12 |
| US9457201B2 (en) | 2016-10-04 |
| WO2013170223A1 (en) | 2013-11-14 |
| AU2013259194A1 (en) | 2014-11-27 |
| CN104363959A (zh) | 2015-02-18 |
| EP2852436A1 (en) | 2015-04-01 |
| JP2015517350A (ja) | 2015-06-22 |
| CA2872934A1 (en) | 2013-11-14 |
| HK1205025A1 (en) | 2015-12-11 |
| AU2013259194B2 (en) | 2016-04-21 |
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