JP6271749B2 - Syringe packaging system with oxygen scavenger - Google Patents

Description

  The present disclosure relates generally to a syringe assembly for fluid delivery. More specifically, the present disclosure provides that the plunger rod and syringe barrel have a low concentration of oxygen in the packaging housing and a low concentration of oxygen contained in the fluid or drug disposed within the syringe barrel. The present invention relates to a syringe assembly that can be placed in a packaging housing.

  Syringe assemblies, and particularly hypodermic syringes, are well known in the medical field of dispensing fluids, such as drugs. Conventional syringes typically include a syringe barrel with an opening at one end and a plunger mechanism disposed through the opposite end. The plunger mechanism typically includes a plunger rod that extends through the barrel, with a plunger head or stopper disposed at the end of the plunger rod within the syringe barrel, and a finger flange at the other end of the plunger rod extending from the syringe barrel. To do. In use, the plunger rod is retracted through the syringe barrel and a fluid such as a medicament is aspirated or filled into the syringe barrel with the plunger rod extending out from the rear end of the syringe barrel. To deliver the drug to the patient, the syringe barrel opening is a hypodermic needle mounted at the front end of the syringe barrel, or a luer fitting that extends from the syringe barrel for attachment to the patient fluid line And is adapted to be in fluid communication with the patient. After applying force and pushing the plunger rod and stopper down and through the syringe barrel toward the front end of the syringe barrel, the contents of the syringe are thereby pushed out of the syringe barrel and delivered to the patient through the opening in the front end .

  In general, hypodermic syringes are packaged as “pre-fill” devices, and syringes are pre-filled with medication before being packaged and delivered to a patient. In this way, the user does not need to fill the device prior to injection, thereby saving time and maintaining a consistent volume for delivery. However, packaging of such pre-filled syringes can degrade drugs or drugs contained within the syringe barrel, such as oxygen in the packaging material, and reduce the shelf life of the pre-filled syringe assembly. It may contain atmospheric gases that can be shortened. Therefore, there is a need for a syringe wrapping material that reduces the oxygen concentration therein.

  According to one embodiment of the present invention, a syringe packaging system includes a syringe barrel, a plunger rod, an oxygen scavenger, and a packaging member. The packaging member defines a first compartment, a second compartment, and a third compartment, and the first compartment, the second compartment, and the third compartment are in gas communication. The first compartment has a structure for receiving a syringe barrel therein, the second compartment has a structure for receiving a plunger rod therein, and the third compartment receives an oxygen scavenger therein. It has a structure. The packaging member contains a syringe barrel, a plunger rod, and an oxygen scavenger, the oxygen scavenger draws oxygen from within the syringe barrel, and the first, second, and third compartments of the packaging member Adapted to absorb oxygen contained in at least one of them.

US patent application Ser. No. 14 / 207,207

  In some configurations, the syringe barrel comprises a first end, a second end, and a sidewall extending therebetween and defining a chamber having an interior, the syringe barrel comprising a chamber And a stopper slidably disposed in the interior of the housing. The plunger rod may be engageable with a portion of the stopper. In some configurations, the syringe packaging system comprises a fluid disposed within the chamber of the syringe barrel.

  The packaging member contains a syringe barrel, a plunger rod, and an oxygen scavenger, the oxygen scavenger being adapted to draw oxygen from a fluid disposed in the syringe barrel chamber. In one configuration, the oxygen scavenger is adapted to draw oxygen from the fluid disposed in the chamber through the stopper. In another configuration, the oxygen scavenger is adapted to draw oxygen from the fluid disposed in the chamber through the syringe barrel.

  The packaging member may also include a sealing member such that the packaging member and the sealing member contain the syringe barrel, the plunger rod, and the oxygen scavenger. The first compartment, the second compartment, and the third compartment may be formed as part of a single compartment. In some configurations, the syringe packaging system also includes a partition member that is receivable within the packaging member, the partition member and the packaging member defining a first compartment, a second compartment, and a third compartment. . The partition member may define a plurality of gas holes that allow gas communication between at least two of the first compartment, the second compartment, and the third compartment.

  The wrapping member may also include sidewalls that define opposing slots for receiving the partition members. The packaging member may optionally include at least one rib for engaging the oxygen scavenger to secure the oxygen scavenger within the packaging member. The packaging member may also include a support member for engaging the plunger rod to secure the plunger rod within the packaging member. Optionally, the packaging member may comprise a support member for engaging the syringe barrel to secure the syringe barrel within the packaging member.

  In yet another configuration, the wrapping member may comprise a tapered portion of the side wall for securing the oxygen scavenger within the wrapping member. The packaging member may include a first protrusion (first bulge) and a second protrusion (second bulge), and the partition member may include the first protrusion and the second protrusion. Or at least partially acceptable between the protrusions. The packaging member may also include fins for engaging the oxygen scavenger to secure the oxygen scavenger within the packaging member. As appropriate, the packaging member includes an inner wall for fixing the oxygen scavenger in the packaging member and a lid having an opening, and the lid can be secured to the inner wall. The oxygen scavenger may include a polyolefin-based material.

  In accordance with another embodiment of the present invention, a syringe packaging system has a first end, a second end, and a sidewall extending therebetween and defining a chamber having an interior. A syringe barrel is provided. The syringe packaging system also includes a stopper slidably disposed within the chamber of the syringe barrel and a fluid disposed within the chamber of the syringe barrel, at least one of the syringe barrel and the stopper being Formed from an oxygen permeable material. The syringe packaging system also includes a plunger rod that is engageable with a portion of the stopper and an oxygen scavenger. The syringe packaging system is formed from a material that is generally oxygen impermeable and defines a first compartment, a second compartment, and a third compartment, the first compartment, the second compartment. And the third compartment further comprises a packaging member in gas communication. The first compartment has a structure for receiving a syringe barrel therein, the second compartment has a structure for receiving a plunger rod therein, and the third compartment receives an oxygen scavenger therein. It has a structure. The packaging member contains the syringe barrel, plunger rod, and oxygen scavenger, and the oxygen scavenger draws oxygen from the fluid disposed in the syringe barrel chamber and absorbs the oxygen contained in the packaging member. Adapted to do.

  In some configurations, the oxygen scavenger is adapted to draw oxygen from the fluid disposed in the chamber through the stopper. In other configurations, the oxygen scavenger is adapted to draw oxygen from the fluid disposed in the chamber through the syringe barrel.

  The packaging member may include a sealing member, and the packaging member and the sealing member may contain a syringe barrel, a plunger rod, and an oxygen scavenger. The first compartment, the second compartment, and the third compartment may be formed as part of a single compartment. Optionally, the packaging member can be formed from a polyester material or a polyamide material.

  In accordance with yet another embodiment of the present invention, a syringe packaging system comprises a syringe barrel, an oxygen scavenger, and a packaging member that defines a first compartment and a second compartment, the first compartment and The second compartment is in gas communication. The first compartment has a structure for receiving a syringe barrel therein and the second compartment has a structure for receiving an oxygen scavenger therein. The packaging member contains a syringe barrel and an oxygen scavenger, and the oxygen scavenger is adapted to draw oxygen from within the syringe barrel.

  In some configurations, the syringe barrel comprises a first end, a second end, and a sidewall extending therebetween and defining a chamber having an interior, the syringe barrel comprising a chamber And a stopper slidably disposed in the interior of the housing. In some configurations, the syringe packaging system also includes a fluid disposed within the chamber of the syringe barrel. The packaging member contains a syringe barrel and an oxygen scavenger, and the oxygen scavenger can be adapted to draw oxygen from a fluid disposed in the chamber of the syringe barrel. The oxygen scavenger may be adapted to draw oxygen from the fluid disposed in the chamber through the stopper. In other configurations, the oxygen scavenger may be adapted to draw oxygen from the fluid disposed in the chamber through the syringe barrel.

The foregoing and other features and advantages of the present disclosure, as well as the manner in which they are realized, will become more apparent upon reference to the following description of the embodiments of the present disclosure taken in conjunction with the accompanying drawings. It will be understood more deeply.
1 is an exploded perspective view of a syringe packaging system according to an embodiment of the present invention. FIG. 2 is an assembled, perspective view of the syringe packaging system of FIG. 1 according to an embodiment of the present invention. FIG. 2 is an assembled, perspective view of the syringe packaging system of FIG. 1 with a sealing member sealing the syringe packaging system, according to one embodiment of the present invention. 2B is a cross-sectional view of the syringe packaging system of FIG. 2A according to one embodiment of the present invention. 2B is a cross-sectional view of the syringe packaging system of FIG. 2A, wherein fluid is disposed in the chamber of the syringe barrel, according to one embodiment of the present invention. It is a perspective view of the packaging member by one Embodiment of this invention. It is a top view of the packaging member by one Embodiment of this invention. It is a side view of the packaging member by one Embodiment of this invention. FIG. 7 is a cross-sectional view of the packaging member taken along line 7-7 of FIG. 6 in accordance with an aspect of the present invention. It is another side view of the packaging member by one Embodiment of this invention. FIG. 9 is a cross-sectional view of the packaging member taken along line 9-9 of FIG. 8 in accordance with an aspect of the present invention. It is a perspective view of the partition member by one Embodiment of this invention. It is a side view of the partition member by one Embodiment of this invention. It is a top view of the partition member by one Embodiment of this invention. It is another side view of the partition member by one Embodiment of this invention. It is a bottom view of the partition member by one Embodiment of this invention. 2 is an exploded perspective view of a syringe barrel and plunger rod according to an embodiment of the present invention. FIG. 1 is a perspective view of an oxygen scavenger according to an embodiment of the present invention. 1 is an exploded perspective view of a syringe barrel, a stopper adapter, and a plunger rod according to an embodiment of the present invention. FIG. 6 is a partial cross-sectional view of a plunger rod and stopper adapter in an engaged position according to an embodiment of the present invention. 2 is a partial cross-sectional view of a plunger rod and stopper adapter in an engaged position and a stopper adapter and stopper in an engaged position according to an embodiment of the present invention. FIG. FIG. 3 is an exploded view of a syringe barrel, stopper, stopper adapter, and plunger rod according to an embodiment of the present invention. FIG. 20 is an exploded cross-sectional view of the syringe barrel, stopper, stopper adapter, and plunger rod of FIG. 19 taken along line 20-20 according to one embodiment of the present invention. FIG. 18 is an assembled perspective view of the syringe barrel, stopper, and plunger rod of FIG. 17 according to one embodiment of the present invention. FIG. 3 is a top view of a syringe assembly according to an embodiment of the present invention. FIG. 23 is a cross-sectional view of the syringe assembly taken along line 23-23 of FIG. 22 in accordance with an aspect of the present invention. It is a perspective view of the packaging member by one Embodiment of this invention. It is a side view of the packaging member by one Embodiment of this invention. FIG. 27 is a cross-sectional view of a packaging member taken along line 26-26 of FIG. 25 in accordance with an aspect of the present invention. It is another side view of the packaging member by one Embodiment of this invention. FIG. 28 is a cross-sectional view of a packaging member taken along line 28-28 of FIG. 27 in accordance with an aspect of the present invention. It is a top view of the packaging member by one Embodiment of this invention. It is a perspective view of the partition member and oxygen scavenger by one Embodiment of this invention. 1 is a schematic cross-sectional view of a syringe packaging system according to an embodiment of the present invention. FIG. 32 is an enlarged partial view of the syringe packaging system of FIG. 31 according to one embodiment of the present invention. FIG. 32 is an enlarged partial cross-sectional view of the syringe packaging system of FIG. 31 with a partition member received between the first ridge and the second ridge, according to one embodiment of the present invention. It is a perspective view of the packaging member by one Embodiment of this invention. It is a side view of the packaging member by one Embodiment of this invention. FIG. 36 is a cross-sectional view of the wrapping member taken along line 36-36 of FIG. 35 in accordance with an aspect of the present invention. It is another side view of the packaging member by one Embodiment of this invention. FIG. 38 is a cross-sectional view of the packaging member taken along line 38-38 of FIG. 37 in accordance with an aspect of the present invention. 1 is an exploded perspective view of a syringe packaging system according to an embodiment of the present invention. 1 is a side view of a lid and an oxygen scavenger according to an embodiment of the present invention. 1 is a perspective view of a lid and an oxygen scavenger according to an embodiment of the present invention. FIG. It is a top view of the packaging member by one Embodiment of this invention. 1 is a side view of a lid and an oxygen scavenger according to an embodiment of the present invention. 1 is a schematic cross-sectional view of a syringe packaging system according to an embodiment of the present invention. It is a perspective view of the packaging member by one Embodiment of this invention. It is a top view of the packaging member by one Embodiment of this invention. It is a side view of the packaging member by one Embodiment of this invention. FIG. 48 is a cross-sectional view of the wrapping member taken along line 48-48 of FIG. 47 in accordance with an aspect of the present invention. It is another side view of the packaging member by one Embodiment of this invention. FIG. 50 is a cross-sectional view of a packaging member taken along line 50-50 of FIG. 49 in accordance with an aspect of the present invention. 1 is an exploded perspective view of a syringe packaging system according to an embodiment of the present invention. FIG. 52 is an assembled, perspective view of the syringe packaging system of FIG. 51 according to one embodiment of the present invention. FIG. 53 is a cross-sectional view of the syringe packaging system of FIG. 52 according to one embodiment of the invention. It is a perspective view of the packaging member by one Embodiment of this invention. It is a top view of the packaging member by one Embodiment of this invention. It is a side view of the packaging member by one Embodiment of this invention. FIG. 57 is a cross-sectional view of a packaging member taken along line 57-57 of FIG. 56 according to one aspect of the present invention. It is another side view of the packaging member by one Embodiment of this invention. FIG. 59 is a cross-sectional view of a packaging member taken along line 59-59 of FIG. 58 in accordance with an aspect of the present invention. 1 is an exploded perspective view of a syringe packaging system according to an embodiment of the present invention. FIG. 61 is an assembled, top view of the syringe packaging system of FIG. 60 according to one embodiment of the present invention. It is a perspective view of the packaging member by one Embodiment of this invention. It is a top view of the packaging member by one Embodiment of this invention. It is a side view of the packaging member by one Embodiment of this invention. FIG. 67 is a cross-sectional view of the packaging member taken along line 65-65 of FIG. 64 in accordance with an aspect of the present invention. It is another side view of the packaging member by one Embodiment of this invention. FIG. 67 is a cross-sectional view of the packaging member taken along line 67-67 of FIG. 66 according to one aspect of the present invention. 1 is an exploded perspective view of a syringe packaging system according to an embodiment of the present invention. FIG. 69 is an assembled, perspective view of the syringe packaging system of FIG. 68 according to one embodiment of the present invention. FIG. 70 is a cross-sectional view of the syringe packaging system of FIG. 69 according to one embodiment of the invention. Corresponding reference characters indicate corresponding parts throughout the several views. The illustrations set forth herein illustrate exemplary embodiments of the disclosure, and such illustrations should not be construed as limiting the scope of the disclosure in any way.

  For the following explanation, the words “top”, “bottom”, “right”, “left”, “vertical”, “horizontal”, “top”, “bottom”, “horizontal”, “vertical”, And their derivatives are intended to relate to the present invention as oriented in the drawings. However, it is to be understood that the invention can assume various alternative modifications unless explicitly stated to the contrary. It should also be understood that the specific devices illustrated in the accompanying drawings and described in the following specification are merely exemplary embodiments of the invention. Accordingly, specific dimensions and other physical characteristics related to the embodiments disclosed herein are not to be considered as limitations.

  In the following description, “distal” refers generally to the end of a syringe assembly adapted to contact a patient, such as a needle assembly or IV connection assembly, and / or engage a separate device. “Proximal” refers to the direction opposite to the distal direction, ie, away from the end of the syringe assembly adapted to engage a separate device. For purposes of this disclosure, the above references are used in the description of components of a syringe assembly according to the present disclosure.

  1-23 illustrate an exemplary embodiment of the present disclosure. With reference to FIGS. 1-9 and 15-23, the syringe packaging system 10 includes a packaging member 12, a syringe assembly 13 including a syringe barrel 14 and a removable plunger rod 16, and an oxygen scavenger 18. The packaging member 12 contains the syringe barrel 14, plunger rod 16, and oxygen scavenger 18, so that the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and absorbs oxygen contained within the packaging member 12. It is adapted to. The syringe packaging system 10 of the present disclosure can also reduce the storage space of the syringe assembly.

  1-3B, the packaging member 12 is sized and adapted to receive a syringe barrel 14, a plunger rod 16, and an oxygen scavenger 18 therein. With reference to FIGS. 15 and 17-23, in one embodiment, the syringe assembly 13 includes a syringe barrel 14, a plunger rod 16, and a stopper assembly comprising a stopper 19 and a stopper adapter 21. The syringe assembly 13 can be adapted to dispense and deliver fluid and / or collected fluid. For example, the syringe assembly 13 can be used to inject or infuse fluids such as drugs or drugs into the patient. The syringe assembly 13 is contemplated for use in connection with a needle, such as by connecting the syringe assembly 13 to a separate needle assembly (not shown), or for connection to a vein (IV) connection assembly (not shown). The It can be appreciated that the present disclosure can be used with any type of syringe assembly, particularly those that are placed in a controlled storage environment with limited storage space. These types of syringes include conventional pre-filled syringe assemblies, metered syringes, suction syringes for drawing fluid from a patient or drug from a container, and the like.

  With reference to FIGS. 15 and 17-23, the syringe barrel 14 generally has a sidewall 30 that extends between a first or distal end 32 and a second or proximal end 34. A barrel main body portion is provided. Side wall 30 defines an elongated opening or interior chamber 36 of syringe barrel 14. In one embodiment, the internal chamber 36 may span the syringe barrel 14 such that the syringe barrel 14 is cannulated along its entire length. In one embodiment, the syringe barrel 14 may take the general form of an elongated cylindrical barrel as is known in the art for the general shape of a hypodermic syringe. In alternative embodiments, the syringe barrel 14 may take other forms for containing fluid for delivery, such as, for example, the general form of an elongated rectangular barrel. The syringe barrel 14 may be formed from glass or injection molded from thermoplastic materials such as polypropylene and polyethylene according to techniques known to those skilled in the art, although the syringe barrel 14 may be other suitable It will be appreciated that the material can be made according to other applicable techniques. In some configurations, the syringe barrel 14 may include a flange 40 that extends outwardly around at least a portion of the proximal end 34. The flange 40 may be configured to be easily grasped by a medical practitioner, as will be described herein.

  The distal end 32 of the syringe barrel 14 includes an outlet opening 38 (FIGS. 3A and 3B) in fluid communication with the chamber 36. The outlet opening 38 may be sized and adapted to engage a separate device, such as a needle assembly or an IV connection assembly, and thus for engagement as conventionally known The mechanism may be provided. For example, the distal end 32 is a generally tapered luer tip for engaging with an optional separate tapered luer structure of such a separate device (not shown) for attachment thereto. May comprise a part. In one configuration, both the tapered luer tip and the separate tapered luer structure may comprise a syringe assembly 13. In such a configuration, a separate tapered luer structure can be attached with an attachment mechanism, such as a threaded engagement, for corresponding engagement with a separate device (not shown). In another configuration, the tapered luer tip may be provided for direct engagement with a separate device (not shown). In addition, the mechanism for locking the engagement between them is also at least one of a separate tapered luer structure such as a luer collar or luer lock with a tapered luer tip and / or female thread. Can be provided. Such luer connections and luer locking mechanisms are well known in the art.

  The proximal end 34 of the syringe barrel 14 is generally open at both ends, but is intended to be closed to the external environment as described herein. The syringe barrel 14 may also include markings, such as scales located on the side walls 30 to indicate as to the level or amount of fluid contained within the internal chamber 36 of the syringe barrel 14. Such markings may be provided on the outer surface of the side wall 30, the inner surface of the side wall 30, or may be integrally formed within the side wall 30 of the syringe barrel 14, or may take some other form. In other embodiments, alternatively or in addition, the marking may include a description of the contents of the syringe or other identifying information as may be known in the art, such as a maximum fill line and / or a minimum fill line. Can also be provided.

  Syringe barrel 14 may be useful as a prefilled syringe, and thus fluid F (FIG. 3B), such as a drug or drug, contained in the interior chamber 36 of syringe barrel 14 prefilled by the manufacturer. Can be provided for end use. In this manner, syringe barrel 14 is manufactured, pre-filled with medication, sterilized, and packaged with a suitable packaging material, such as packaging member 12, for delivery, storage, and use by the end user. Can thus eliminate the need for the end user to fill the syringe with medication from a separate vial prior to use. In one such embodiment, the syringe barrel 14 is disposed within the interior chamber 36 of the syringe barrel 14 with a seal 44 disposed at the distal end 32 of the syringe barrel 14 to seal fluid F, such as a drug. A tip cap or sealing cap member 42 may be provided.

  As used herein, the term “drug” refers to a pharmacologically active ingredient and a pharmaceutical liquid composition containing the pharmacologically active ingredient. Pharmaceutical liquid compositions include forms such as solutions, suspensions, emulsions, and the like. These pharmaceutical liquid compositions can be administered orally or by injection.

  Drugs that are oxygen sensitive, ie, can degrade as a result of exposure to oxygen, are suitable for incorporation into the drug packaging systems described herein. Oxygen sensitive drugs include amines, either as salts or free bases, sulfides, allylic alcohols, phenols, and those with other chemical groups that may be reactive with oxygen. Non-limiting examples of oxygen sensitive drugs include morphine, hydromorphone, promethazine, dopamine, epinephrine, norepinephrine, esterified estrogens, ephedrine, pseudoephedrine, acetaminophen, ibuprofen, danofloxacin, erythromycin, penicillin, cyclosporine, methyldopate, Includes cetirizine, diltiazem, verapamil, mexiletine, chlorothiazide, carbamazepine, selegiline, oxybutynin, vitamin A, vitamin B, vitamin C, L-cysteine, L-tryptophan, and the like. In some embodiments, the packaging container of the drug packaging system described herein, eg, syringe barrel 14, contains morphine. In other embodiments, the packaging container of the drug packaging system described herein contains hydromorphone. In further embodiments, the packaging container of the drug packaging system described herein contains promethazine.

  Oxygen sensitive drugs within the drug packaging system described herein are stable at a variety of storage conditions, including ambient conditions, intermediate conditions, and accelerated conditions. Stability as used herein is in line with its specific shelf life, as the formulation is defined in the USP or equivalent monograph of the drug product (especially for the analysis of drug substances). Refers to meeting all stability standards and current stability standards in the ICH Q3B guidance on impurities. All important quality attributes need to be within their acceptance range throughout the shelf life of the formulation. As an example, in order for a morphine formulation to be stable, the analysis of the drug substance, ie morphine, is within the [90.0% -110.0%] range by USP and by ICH Q3B guidelines, All known, i.e., identified, and even unknown degradation products such as hydroxymorphine, norphine-N-oxide, and the like are (NMT) 0.2 % Or less. The stability of oxygen sensitive drugs within the drug packaging system described herein is assessed by HPLC, UPLC, or any other known analytical method.

  In some embodiments, the oxygen sensitive drug is at least 12 months, at least 15 months, at least 18 months, or at least 24 months when stored in the drug packaging system described herein. Meanwhile, it is stable at ambient conditions (for example, 25 ° C./60% RH). In some cases, the oxygen sensitive drug is stable under ambient conditions for at least 24 months when stored in the drug packaging system described herein. In other embodiments, the oxygen sensitive drug is between at least 6 months, at least 8 months, at least 10 months, or at least 12 months when stored in the drug packaging system described herein. Stable under intermediate conditions (for example, 30 ° C./65% RH). In some cases, the oxygen sensitive drug is stable under intermediate conditions for at least 12 months when stored in the drug packaging system described herein. In further embodiments, the oxygen sensitive drug is accelerated conditions (eg, , 40 ° C./75% RH). In some cases, the oxygen sensitive drug is stable under accelerated conditions for at least 6 months when stored in the drug packaging system described herein.

  The drug packaging system described herein is also suitable for drug liquid compositions containing oxygen sensitive excipients. Degradation of oxygen sensitive excipients in a pharmaceutical composition can have a variety of effects ranging from discoloration of the composition to a decrease in the ability or efficiency of the composition and / or adverse reactivity with active pharmaceutical ingredients. Can cause. Non-exclusive examples of oxygen sensitive excipients that benefit from the drug packaging system described herein include polyethylene oxide (PEO) or polyethylene glycol (PEG) and polyoxyethylene alkyl ethers.

  In one embodiment, at least a portion of the syringe barrel 14, such as the sidewall 30, distal end 32, and / or proximal end 34, allows oxygen to escape from the chamber 36 of the syringe barrel 14 as described in more detail below. An oxygen-permeable member that can pass through the oxygen agent 18 is provided. For example, in one embodiment, the tip cap or cap member 42 may be formed from an oxygen permeable material so that oxygen can pass from the chamber 36 of the syringe barrel 14 to the oxygen scavenger 18. In one embodiment, cap member 42 may be formed from a cyclic olefin polymer that is permeable to oxygen and suitable for contacting fluid F. It is further contemplated that the cap member 42 may be formed from other materials that allow oxygen to pass from the chamber 36 of the syringe barrel 14 to the oxygen scavenger 18. In other embodiments, the proximal end 34 or sidewall 30 of the syringe barrel 14 includes and / or includes an oxygen permeable member so that oxygen can pass from the chamber 36 of the syringe barrel 14 to the oxygen scavenger 18. Can be formed.

  With reference to FIGS. 17-23, the syringe assembly 13 is movably or slidably disposed within the interior chamber 36 of the syringe barrel 14 and contacts the inner surface of the sidewall 30 of the syringe barrel 14. A stopper 19 is provided. The stopper 19 is sized relative to the syringe barrel 14 to provide a sealing engagement with the inner surface of the sidewall 30 of the syringe barrel 14. In addition, the stopper 19 includes one or more annular ribs that extend around the periphery of the stopper 19 to enhance sealing engagement between the stopper 19 and the inner surface of the sidewall 30 of the syringe barrel 14. In an alternative embodiment, a single O-ring or multiple O-rings are disposed on the circumference of the stopper 19 to enhance sealing engagement with the inner surface of the sidewall 30 of the syringe barrel 14.

  17-23, in one embodiment, the stopper 19 defines a stopper adapter receiving opening 55 formed therein and includes a threaded portion 57 for securing the stopper adapter 21 to the stopper 19. A first or distal end 51 and a second or proximal end 53 are also provided.

  With reference to FIGS. 17-23, in one embodiment, the stopper adapter 21 defines a plunger receiving opening 54 formed therein, for securing the plunger rod 16 to the stopper 19 via the stopper adapter 21. A first or distal end 50 having a locking feature or engaging portion 56 and a second or proximal end 52 are provided. In one embodiment, referring to FIGS. 17-23, the engagement portion 56 of the stopper adapter 21 includes a protruding annular ring 58 having a tapered portion 60 and a locking end 62 as described in more detail below. Can be prepared. In one embodiment, the protruding annular ring 58 is formed from a rigid, unbent material. In one embodiment, the first end 50 of the stopper adapter 21 includes a threaded portion 64.

  In one embodiment, the stopper adapter 21 may be secured to the stopper 19 by screwing the threaded portion 64 of the stopper adapter 21 into the threaded portion 57 of the stopper 19 as shown in FIG. 18B. In other embodiments, the stopper adapter 21 may be secured to the stopper 19 using a ball stop, locking tab, spring-loaded locking mechanism, latch, adhesive, or other similar mechanism. In all embodiments, the stopper adapter 21 is locked, fixed or engaged with the stopper 19, i.e. significant relative movement between the stopper adapter 21 and the stopper 19 is prevented. It is. In other alternative embodiments, the stopper adapter 21 and the stopper 19 may be integrally formed and both together form a stopper assembly.

  In other embodiments, the stopper adapter 21 and the stopper 19 can be simultaneously formed by a co-extrusion method or the like. In an alternative embodiment, the stopper adapter 21 and the stopper 19 can be integrally formed as a stopper assembly.

  With reference to FIGS. 15 and 17-23, the syringe assembly 13 is connected to the syringe barrel 14 through the outlet opening 38 after connecting the plunger rod 16 to the syringe barrel 14 via the stopper adapter 21 as described in more detail below. The plunger rod 16 constituting a mechanism for dispensing the fluid contained in the internal chamber 36 is further provided. The plunger rod 16 is adapted to feed a stopper 19. In one embodiment, the plunger rod 16 is sized to move within the interior chamber 36 of the syringe barrel 14 as will be described in more detail below, and generally has a first end or distal end. 70, a second or proximal end 72, a flange 74 disposed adjacent to the second end 72, and a locking feature or engagement for securing the plunger rod 16 to the stopper 19. Portion 76. In one embodiment, referring to FIGS. 17-23, the engagement portion 76 of the plunger rod 16 is disposed adjacent to the plunger rod head 78 with a plunger rod head 78 having a deformable restraining member, such as an elastic finger 80. The neck part 82 provided may be provided. The plunger rod head 78 also includes an annular groove 84 disposed between the elastic finger 80 and the neck portion 82. The elastic fingers 80 each include a tapered portion 86 and a locking end 88. The plunger rod head 78 is described in further detail below.

  In another embodiment, the engagement portion 56 of the stopper adapter 21 may comprise a deformable restraining member, eg, an elastic finger, for securing the plunger rod 16 to the stopper 19 via the stopper adapter 21. In other embodiments, the engagement portion 56 of the stopper adapter 21 includes a threaded portion, a snap-fit fitting mechanism, a ball stop, a locking tab, a spring-type locking mechanism, a latch, an adhesive, or a stopper adapter 21. Other similar mechanisms for securing the plunger rod 16 to the stopper 19 may be provided.

  In another embodiment, the engagement portion 76 of the plunger rod 16 may comprise a plunger rod head 78 formed from a rigid, unbent material for securing the plunger rod 16 to the stopper 19 via the stopper adapter 21. . In other embodiments, the engagement portion 76 of the plunger rod 16 includes a threaded portion, a snap-fit mechanism, a ball stop, a lock tab, a spring lock mechanism, a latch, an adhesive, or a stopper adapter 21. Other similar mechanisms for securing the plunger rod 16 to the stopper 19 may be provided.

  1-3B and 16, the oxygen scavenger 18 is associated with the syringe packaging system 10 of the present disclosure. By disposing the oxygen scavenger 18 in the packaging member 12, the oxygen scavenger 18 reduces the oxygen concentration in the packaging member 12, and fluid F (see FIG. 5) disposed in the chamber 36 of the syringe barrel 14. The oxygen contained in 3B) can be removed. For example, oxygen contained in the packaging member 12 is absorbed by the oxygen scavenger 18. In addition, oxygen contained in the chamber 36 of the syringe barrel 14 and / or oxygen contained in the fluid F disposed in the chamber 36 of the syringe barrel 14 is oxygen permeable as described above. Flow from the chamber 36 of the syringe barrel 14 to the oxygen scavenger 18 through at least one portion of the syringe barrel 14, such as the side wall 30 comprising the member, the distal end 32, and / or the proximal end 34. The reduction in oxygen concentration in the wrapping member 12 is included in the wrapping member 12, and atmospheric gases such as oxygen contained in the fluid F disposed in the chamber 36 of the syringe barrel 14 can be used as a drug or drug in the prefilled syringe. This is important because the fluid F can be deteriorated.

  In one embodiment, oxygen scavenger 18 may be formed from a polyolefin-based material, such as a polypropylene or polyethylene material, or similar materials that allow the desired oxygen absorption rate or oxygen reaction rate. In one embodiment, oxygen scavenger 18 may be formed from polymeric materials that incorporate iron, low molecular weight organic compounds such as ascorbic acid and sodium ascorbate, and resins and catalysts. Further, the oxygen scavenger 18 can be formed from other materials that can absorb oxygen contained in the packaging member 12 and remove oxygen contained in the fluid F disposed in the chamber 36 of the syringe barrel 14. It is also contemplated. In some embodiments, materials suitable for oxygen scavengers include metal-based materials that react with it by chemical bonding and generally remove oxygen by forming a metal oxide component. Exemplary oxygen scavengers suitable for use in the system of the present invention are disclosed in the literature incorporated herein by reference (see, for example, US Pat. Metal-based materials include elemental iron, as well as iron oxide, iron hydroxide, iron carbide, and the like. Other metals for use as oxygen scavengers include nickel, tin, copper, and zinc. Metal-based oxygen scavengers typically take the form of a powder to increase surface area. Metal-based oxygen scavenger powder formation is by any known method, including but not limited to atomization, milling, milling, and electrolysis. Additional materials for the oxygen scavenger include polymeric materials that incorporate low molecular weight organic compounds such as ascorbic acid, sodium ascorbate, catechol, and phenol, activated carbon, and resins and catalysts. In some embodiments of the drug packaging system, the oxygen scavenger is a metal-based oxygen scavenger. In some cases of drug packaging systems, the oxygen scavenger is an iron-based oxygen scavenger. In a further case of the drug packaging system, the oxygen scavenger is an iron-based oxygen scavenger in the form of a canister.

  In one embodiment, referring to FIGS. 1, 3A, 3B, and 16, the oxygen scavenger 18 takes the form of a canister. In other embodiments, the oxygen scavenger 18 can take other forms, such as a packet or sachet form. In some embodiments, the oxygen scavenger 18 can be cylindrical, capsule-shaped, or similar shapes that allow the desired absorption or reaction rate. In this way, the size, shape, cross-sectional area, and / or volume of the oxygen scavenger 18 and the location of the oxygen scavenger 18 in the packaging member 12 can be determined by the oxygen scavenger 18 in the oxygen contained in the packaging member 12. It is adapted to absorb and is also adapted to remove oxygen contained in the fluid F disposed in the chamber 36 of the syringe barrel 14 to prevent the fluid F from degrading and to improve the shelf life of the syringe packaging system 10. It may be changed to extend.

  The packaging system described herein improves stability and prevents oxidative degradation of oxygen-sensitive drugs in liquid form, thereby prolonging the product shelf life and extending drug efficacy or Efficiency can be maintained.

  “Oxygen sensitive” or “oxygen sensitive” refers to the ability of a substance to react with oxygen under ambient temperature conditions (eg, 5 ° C. to about 40 ° C.). The chemical reaction may involve the addition of oxygen atoms to the material, the removal of hydrogen from the material, or the loss or removal of one or more electrons from the molecular entity, in which case one or more protons simultaneously There is or is no loss or removal.

  A feature of the drug packaging system herein is that it allows for the configuration and absorption and removal of oxygen in all components of the system. In essence, the oxygen scavenger in the drug packaging system herein is the oxygen in the secondary packaging material, eg, the packaging member 12, the primary packaging material, eg, the syringe barrel 14, and the drug within the primary packaging material. Causes absorption and elimination. The oxygen scavenger further removes the low oxygen inflow through the secondary packaging over time. In this configuration, the amount of residual oxygen present in the primary packaging material and the secondary packaging material, and even the oxygen entering the packaging system from the external environment over time may be reduced or even eliminated by the drug manufacturing process. .

  Another feature of the drug packaging system described herein is that the drug packaging system maintains an oxygen concentration of 0% after removing the initial oxygen in the primary packaging container and secondary packaging for an extended period of time. It is. As a result, the drug packaging system described herein stores oxygen-sensitive drugs beyond conventional packaging and methods such as from inert atmosphere packaging processes (eg, nitrogen atmosphere generation and / or degassing). Increase lifespan. In some embodiments, the drug packaging system described herein has at least about 12 months, at least about 15 months, at least about 18 months, at least about 24 months, at least about 30 months, at least about 36 months, Maintain an oxygen concentration of 0% in the primary and secondary packaging materials for at least about 48 months, or at least about 60 months. In some cases, the drug packaging system described herein maintains 0% oxygen concentration in the primary and secondary packaging materials for at least 12 months. In some cases, the drug packaging system described herein maintains an oxygen concentration of 0% in the primary and secondary packaging materials for at least 24 months. In some cases, the drug packaging system described herein maintains an oxygen concentration of 0% in the primary and secondary packaging materials for at least 36 months.

  In one embodiment, the oxygen scavenger in the drug packaging system herein allows for the rapid uptake of oxygen present in the secondary packaging material. The oxygen in the air at ambient temperature and pressure (1 atm) is about 21% concentration. When the drug packaging system described herein is assembled under air at ambient conditions, the internal environment of the secondary packaging is initially 21% oxygen. The oxygen scavenger of the drug packaging system of the present disclosure quickly reduces the oxygen concentration in the secondary packaging material to 0% within 1 to 3 days. Accordingly, in some embodiments, the oxygen scavenger is within about 7 days, about 6 days, about 5 days, about 4 days, about 3 days, about 2 days, or about 1 day after the initial packaging of the assembly. Reduce oxygen in secondary packaging to 0%. In some embodiments, the oxygen scavenger reduces the oxygen in the secondary packaging material to 0% within about 1 to 7 days. In some embodiments, the oxygen scavenger reduces the oxygen in the secondary packaging material to 0% within about 1 to 3 days. In some embodiments, the oxygen scavenger is about 35%, about 50%, about 60%, about 65%, about 70%, about 75%, about 75% of total oxygen in air per day after the initial packaging of the assembly. Reduce oxygen in secondary packaging by 80%, about 85%, about 90%, or about 95%. In some cases, the oxygen scavenger reduces oxygen in the secondary packaging material by about 50% per day. In other cases, the oxygen scavenger reduces oxygen in the secondary packaging material by about 75% per day. In a further case, the oxygen scavenger reduces oxygen in the secondary packaging material by about 90% per day. In other embodiments, the oxygen scavenger is in the secondary packaging material by about 35% to about 75%, about 50% to about 80%, or about 65% to about 90% per day after the initial packaging of the assembly. Reduce oxygen.

  In further embodiments, the oxygen scavenger is about 2 to about 10 cc oxygen per atm, about 3 to about 8 cc oxygen per atm, or about 4 per day atm in the secondary packaging. To reduce about 6cc of oxygen. In some cases, the oxygen scavenger is about 2, about 3, about 4, about 5, about 6, about 7, about 8, about 9, or about 10 cc per atm per day in the secondary packaging. Reduce oxygen. In some cases, the oxygen scavenger reduces about 4 cc of oxygen per atm per day. In other cases, the oxygen scavenger reduces about 6 cc of oxygen per atm per day. In a further case, the oxygen scavenger reduces about 8 cc of oxygen per atm per day.

  Another feature of the oxygen scavenger is that it maintains an oxygen concentration of 0% after removing the initial oxygen in the secondary packaging over a long period of time. In some embodiments, the oxygen scavenger maintains an oxygen concentration of 0% in the secondary packaging during the entire shelf life of the drug. In some embodiments, the oxygen scavenger is at least about 12 months, at least about 15 months, at least about 18 months, at least about 24 months, at least about 30 months, at least about 36 months, at least about 48 months, or at least about Maintain an oxygen concentration of 0% in the secondary packaging for 60 months. In some cases, the oxygen scavenger maintains a 0% oxygen concentration in the secondary packaging for at least 12 months. In some cases, the oxygen scavenger maintains a 0% oxygen concentration in the secondary packaging for at least 24 months. In some cases, the oxygen scavenger maintains a 0% oxygen concentration in the secondary packaging for at least 36 months.

  An advantageous feature of the oxygen scavenger in the drug packaging system herein is the absorption and removal of oxygen present in the primary packaging and in the liquid drug itself. It has been found that oxygen scavengers in the exemplary packaging system have removed residual oxygen in the primary packaging material and in the liquid over time to reduce the oxygen concentration to 0%.

  The oxygen scavenger also maintains an oxygen concentration of 0% in some embodiments after removing the initial oxygen in the primary packaging over an extended period of time. In some embodiments, the oxygen scavenger maintains 0% oxygen concentration in the primary packaging during the entire shelf life of the drug. In some embodiments, the oxygen scavenger is at least about 12 months, at least about 15 months, at least about 18 months, at least about 24 months, at least about 30 months, at least about 36 months, at least about 48 months, or at least about Maintain a 0% oxygen concentration in the primary packaging for 60 months. In some cases, the oxygen scavenger maintains a 0% oxygen concentration in the primary packaging for at least 12 months. In some cases, the oxygen scavenger maintains a 0% oxygen concentration in the primary packaging for at least 24 months. In some cases, the oxygen scavenger maintains a 0% oxygen concentration in the primary packaging for at least 36 months.

  An interesting property of the drug packaging system herein is that after the oxygen in the primary and secondary packaging materials is removed by the oxygen scavenger, the air pressure in the secondary packaging environment is below atmospheric pressure, creating a vacuum effect. That is.

  The ability of the drug packaging system described herein to absorb oxygen to the oxygen scavenger is such that the initial oxygen concentration of the primary and secondary packaging materials is zero at a rate as described in the previous embodiment. It includes the ability to reduce to a% oxygen concentration and maintain a 0% oxygen concentration over a period of time as described in the previous embodiment. The oxygen absorption capacity can be optimized according to the material used in the secondary packaging material, the surface area of the secondary packaging material, and the amount of initial oxygen in the secondary packaging material and the primary packaging material.

  Referring to FIGS. 1-9, a syringe packaging system 10 includes a packaging member 12 formed from a material that is generally oxygen-impermeable and a sealing member 15 (FIG. 2B) that can be removably attached to the packaging member 12. ). The packaging member 12 is sized and adapted to receive each of the syringe barrel 14, plunger rod 16, and oxygen scavenger 18 therein as will be described in more detail below.

  The sealing member 15 is for lowering the oxygen concentration in the packaging member 12 by sealing the syringe barrel 14, plunger rod 16, and oxygen scavenger 18 within the packaging member 12, as will be described in more detail below. Provides an additional mechanism. In one embodiment, the sealing member 15 can be formed from an aluminum-based material so as to achieve a sufficient seal with the packaging member 12 as described below. In one embodiment, the sealing member 15 may be formed from a material that is generally oxygen impermeable.

  1-9, the wrapping member 12 is sized to receive a syringe barrel 14, plunger rod 16, and oxygen scavenger 18 therein. In one embodiment, the wrapping member 12 defines a first compartment 100, a second compartment 102, and a third compartment 104. The first compartment 100 is sized and adapted to receive the syringe barrel 14 therein, and the second compartment 102 is sized and adapted to receive the plunger rod 16 therein, The third compartment 104 is sized and adapted to receive the oxygen scavenger 18 therein. The first compartment 100, the second compartment 102, and the third compartment 104 are in gas communication with them. In this way, the packaging member 12 contains the syringe barrel 14, plunger rod 16 and oxygen scavenger 18, and the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and the first compartment 100 of the packaging member 12. , Adapted to absorb oxygen contained in the second compartment 102 and the third compartment 104.

  With reference to FIGS. 1-9, the packaging member 12 includes a first end or upper end 110, a second end or lower end 112, and a side wall 114 extending between the upper end 110 and the lower end 112. . The packaging member 12 includes a locking lip 116 at the upper end 110. Disposed below the locking lip 116 is more than the cross section disposed below the upper tray portion 118, ie, the compartment portion 120, such that the step 122 is defined therebetween. An upper tray portion 118 having a cross section with a large area. Upper tray portion 118 receives and supports flange 40 of syringe barrel 14 and flange 74 of plunger rod 16 as will be described in more detail below. Referring to FIG. 5, in one embodiment, the inner surface 115 of the side wall 114 of the packaging member 12 defines opposing slots 124 that extend along the longitudinal axis of the packaging member 12. With reference to FIGS. 3A, 5, and 9, the inner surface 115 of the side wall 114 of the packaging member 12 includes opposing protrusions or locking ribs 126.

  In one embodiment, the wrapping member 12 is formed from a material that is generally oxygen impermeable or a high oxygen barrier material, ie, a low oxygen permeable material. For example, the wrapping member 12 may be formed from a blend from an extremely high oxygen barrier, such as a polyester material or derivative thereof, a polyamide material or derivative thereof, or ethylene vinyl alcohol or a similar material. In one embodiment, the wrapping member 12 provides a single barrier material, or a barrier material or multiple layers, one or more of the layers providing the required barrier, while the other layer is a non-barrier material, Can be formed from a combination to provide unique mechanical properties or other material properties. In one embodiment, the plurality of layers of the wrapping member 12 can be co-injection molding of active oxygen material with the base resin or 2 with respect to or without the location of the barrier or non-barrier material in the overall packaging structure. It can be formed by single piece injection molding or blending, or similar processes. In one embodiment, the thickness of the wrapping member 12 may be as thin as 0.2 mm and as thick as 1.2 mm as long as it provides the necessary mechanical strength and oxygen barrier requirements are met.

  In one embodiment, the surface properties of the oxygen scavenger 18 and the material for the packaging member 12, such as the coefficient of friction, may cause the oxygen scavenger 18 and the packaging member 12 without causing damage to any of the components of the syringe packaging system 10. It is a characteristic that allows a desired and smooth movement between the two.

  With reference to FIGS. 1-3B and 10-14, the syringe packaging system 10 includes a partition member 130 that is receivable within the packaging member 12. The partition member 130 includes a vertical wall 132 having a first end 134 and a second end 136. The partition member 130 also includes a horizontal wall 138 disposed at the second end 136 of the vertical wall 132. In one embodiment, the vertical wall 132 and the horizontal wall 138 together form a generally T shape. The first end 134 of the vertical wall 132 of the partition member 130 includes a flange 140. The horizontal wall 138 of the partition member 130 defines a plurality of gas holes 142. 10 to 12, the width of the vertical wall 132 is larger than the width of the horizontal wall 138. In this way, the first side wall 144 and the second side wall 146 of the vertical wall 132 extend outwardly from the horizontal wall 138 as shown in FIGS.

  All of the components of the syringe packaging system 10 may be made from any known material, preferably from a medical grade polymer.

  Next, the packaging of the syringe barrel 14, plunger rod 16, and oxygen scavenger 18 in the packaging member 12 will be described with reference to FIGS. Initially, syringe barrel 14, plunger rod 16, and packaging member 12 are sterilized according to techniques known to those skilled in the art. In some embodiments, the syringe barrel 14 can be pre-filled as described above.

  Next, as shown in FIGS. 3A and 3B, the oxygen scavenger 18 is positioned horizontally in the packaging member 12 adjacent the lower end 112 of the packaging member 12 so that the oxygen scavenger 18 is positioned in the packaging member 12. Is inserted into the partition portion 120 of the first embodiment.

  Next, the partition member 130 is received within the packaging member 12 as shown in FIGS. In order to secure the partition member 130 within the packaging member 12, the first side wall 144 and the second side wall 146 of the vertical wall 132 of the partition member 130 are each positioned within the opposing slots 124 of the packaging member 12 to partition the partition member 130. The member 130 is generally inserted into the packaging member 12 in the direction along arrow A (FIG. 1) or moved axially. As shown in FIGS. 3A and 3B, when additional force is applied to the partition member 130 and the partition member 130 is moved axially within the packaging member 12 in a direction generally along arrow A, the partition member 130. The horizontal wall 138 of the partition member 130 moves forward beyond the locking rib 126 of the packaging member 12, that is, slides over the locking rib 126 and passes the partition member 130 to the packaging member 12. The locking rib 126 of the packaging member 12 is deformed outward until it is locked. After the horizontal wall 138 of the partition member 130 slides over the locking rib 126 of the wrapping member 12, the locking rib 126 is deformed as shown in FIGS. 3A and 3B. No or return to original position. In this position, referring to FIGS. 3A and 3B, the locking rib 126 abuts, contacts, or engages the horizontal wall 138 of the partition member 130 to lock the partition member 130 to the packaging member 12. Or fix. This configuration ensures that the partition member 130 is secured to the wrapping member 12, thereby preventing significant relative movement between the partition member 130 and the wrapping member 12. Thus, the partition member 130 and the packaging member 12 define the first compartment 100, the second compartment 102, and the third compartment 104. The first compartment 100 is sized and adapted to receive the syringe barrel 14 therein, and the second compartment 102 is sized and adapted to receive the plunger rod 16 therein, The third compartment 104 is sized and adapted to receive the oxygen scavenger 18 therein. The first compartment 100, the second compartment 102, and the third compartment 104 are in gas communication with them. In one embodiment, the gas holes 142 in the horizontal wall 138 of the partition member 130 provide gas communication between the third compartment 104, the first compartment 100, and the second compartment 102. In this way, the packaging member 12 contains the syringe barrel 14, plunger rod 16 and oxygen scavenger 18, and the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and the first compartment 100 of the packaging member 12. , Adapted to absorb oxygen contained in the second compartment 102 and the third compartment 104.

  In addition, the partition member 130 is secured to the packaging member 12 as described above, thereby preventing significant relative movement between the partition member 130 and the packaging member 12, and the partition member 130 and The packaging member 12 constitutes a third compartment 104 that secures the oxygen scavenger 18 within the packaging member 12 such that the oxygen scavenger 18 is prevented from being removed from the packaging member 12.

  Referring now to FIGS. 1-3B, the syringe barrel 14 is configured such that the first barrel of the packaging member 12 is such that the flange 40 of the syringe barrel 14 abuts the upper tray portion 118 as shown in FIGS. 3A and 3B. It is inserted in the compartment 100. The syringe barrel 14 is properly inserted into the first compartment 100 of the packaging member 12, and then the plunger rod 16 is inserted into the second compartment 102 of the packaging member 12 as shown in FIGS. 3A and 3B. Is done. In one embodiment, the upper tray portion 118 of the wrapping member 12 has the syringe rod 14 on one side with the flange 74 of the plunger rod 16 with the plunger rod 16 inserted into the second compartment 102 of the wrapping member 12. A plunger rod support member that abuts against the flange 40 and abuts with the plunger rod support member on the other side may be provided.

  As described above, after the syringe packaging system 10 is properly sterilized, at least a portion of the syringe barrel 14 may be properly inserted into the first compartment 100 of the packaging member 12. , At least a portion of the plunger rod 16 may be suitably inserted into the second compartment 102 of the packaging member 12, and at least a portion of the oxygen scavenger 18 is within the third compartment 104 of the packaging member 12. It may be inserted appropriately. Next, the sealing member 15 (FIG. 2B) seals the syringe barrel 14, the plunger rod 16, and the oxygen scavenger 18 in the packaging member 12 in cooperation with the first end 110 of the packaging member 12. Used to stop, ie the sealing member 15 and the packaging member 12 together form a leak-proof and protective housing, the contents of the syringe barrel 14, the plunger rod 16, and the packaging member 12. It constitutes a substantially impermeable housing that protects the oxygen scavenger 18 contained therein and / or maintains a sealed and sterilized environment within the packaging member 12. In addition, the sealing member 15 and the wrapping member 12 together seal the syringe barrel 14, plunger rod 16, and oxygen scavenger 18 within the wrapping member 12 to provide oxygen that is external to the syringe packaging system 10. Provides an additional mechanism for reducing the oxygen concentration in the packaging member 12 by preventing it from entering the sealed packaging member 12. The sealing member 15 and the wrapping member 12 together form a sufficient seal at a range of temperature, pressure, and humidity levels.

  As previously described, by placing the oxygen scavenger 18 within the sealed packaging member 12, the oxygen scavenger 18 reduces the oxygen concentration within the packaging member 12 and reduces the oxygen in the syringe barrel 14. Oxygen contained in the fluid F (FIG. 3B) disposed in the chamber 36 can be removed. Oxygen contained in the packaging member 12 is absorbed by the oxygen absorber 18. In addition, oxygen contained in the chamber 36 of the syringe barrel 14 and / or oxygen contained in the fluid F disposed in the chamber 36 of the syringe barrel 14 is oxygen permeable as described above. Flow from the chamber 36 of the syringe barrel 14 to the oxygen scavenger 18 through a portion of the syringe barrel 14 comprising the member. The reduction in oxygen concentration in the wrapping member 12 is included in the wrapping member 12, and atmospheric gases such as oxygen contained in the fluid F disposed in the chamber 36 of the syringe barrel 14 can be used as a drug or drug in the prefilled syringe. This is important because the fluid F can be deteriorated.

  The syringe packaging system of the present disclosure can also reduce the storage space of the syringe assembly. By separating and disconnecting the syringe assembly 13 including the plunger rod 16 from the syringe barrel 14, the plunger rod 16 and the syringe barrel 14 are placed in the packaging member 12 to allow for a reduction in storage space for the syringe assembly 13. Can be placed separately. For example, a conventional pre-filled syringe is typically packaged with a pre-filled fluid in the syringe barrel along with a plunger rod that is retracted from the rear or proximal end of the syringe barrel. Thus, such pre-filled syringe packaging is bulky and clunky for shipping and storage. For example, the total length of a conventional prefilled syringe to be packaged is equal to the length of the syringe barrel and the length that the plunger rod extends outward from the syringe barrel. By separating and disconnecting the syringe assembly 13 that includes the plunger rod 16 from the syringe barrel 14, the plunger rod 16 and syringe barrel 14 are shown in FIGS. 3A and 3B to allow the storage space of the syringe assembly 13 to be reduced. It can be placed separately in the wrapping member 12 as shown. In this way, the total length of the syringe assembly 13 to be packaged is equal to the length of the syringe barrel 14. Thus, the syringe assembly 13 according to the present invention allows the plunger rod 16 and syringe barrel 14 to be packaged so as to allow a storage space to be reduced.

  In addition, according to the syringe assembly of the present invention, after removal of the plunger rod 16 and syringe barrel 14 from the wrapping member 12, the plunger rod 16 collects the fluid and / or delivers the fluid to deliver the fluid. 14 can be quickly and easily fixed.

  With reference to FIGS. 3A and 3B, the oxygen scavenger 18 is positioned within the packaging member 12 under the plunger rod 16, ie, the oxygen scavenger 18 is adjacent to the closed lower end 112 of the packaging member 12. Once positioned, the plunger rod 16 is positioned over the oxygen scavenger 18 as shown in FIGS. 3A and 3B. For example, the third compartment 104 sized and adapted to receive the oxygen scavenger 18 therein is sized to receive the plunger rod 16 therein as shown in FIGS. 3A and 3B. Is determined and placed under the adapted second compartment 102. In this manner, the oxygen scavenger 18 is also prevented from being removed from the packaging member 12 after the plunger rod 16 and the syringe barrel 14 are removed from the packaging member 12. With reference to FIGS. 24-70, in another exemplary embodiment of the present disclosure, the oxygen scavenger 18 is positioned within a packaging member under the plunger rod 16, ie, the oxygen scavenger 18 is a packaging member. The plunger rod 16 is positioned over the oxygen scavenger 18 and is positioned adjacent to the closed lower end of.

  1-3B, 15, and 17-23, the syringe barrel 14 and plunger rod 16 are then secured together to form a syringe assembly and housed in the chamber 36 of the syringe barrel 14. The removal of the syringe barrel 14 and plunger rod 16 from the packaging member 12 so that fluids such as medication can be expelled is described. Initially, the user removes syringe barrel 14 and plunger rod 16 from packaging member 12. To remove the syringe barrel 14 and plunger rod 16 from the wrapping member 12, in one embodiment, the user may first check to ensure that the tear strip or other tamper proof member has not been breached. it can. The user can then remove the tamper proof member and then break the seal described above between the sealing member 15 (FIG. 2B) and the packaging member 12.

  When the seal between the sealing member 15 and the packaging member 12 is broken, the user grasps the flange 74 of the plunger rod 16, pulls the flange 74 in the longitudinal direction, and pulls the plunger rod 16 in the second direction of the packaging member 12. Can be removed from the compartment 102. The user then grasps the flange 40 of the syringe barrel 14 located in the upper tray portion 118 of the packaging member 12 and pulls the flange 40 longitudinally, causing the syringe barrel 14 to move to the first compartment 100 of the packaging member 12. Can be removed from. When the plunger rod 16 and syringe barrel 14 are removed from the wrapping member 12, the plunger rod 16 and syringe barrel 14 are secured together to provide a syringe adapted for fluid dispensing and delivery and / or fluid recovery. An assembly 13 can be formed.

  As described above, the partition member 130 is secured to the packaging member 12, thereby preventing significant relative movement between the partition member 130 and the packaging member 12, and the partition member 130 and the packaging member 12. A third that secures the oxygen scavenger 18 within the packaging member 12 such that the oxygen scavenger 18 is prevented from being removed from the packaging member 12 when the syringe barrel 14 and plunger rod 16 are removed from the packaging member 12. This section 104 is configured.

  Referring now to FIGS. 17-23, one embodiment of a locking feature operable to secure the plunger rod 16 to the syringe barrel 14 via the stopper adapter 21 will be described. With the plunger rod head 78 of the plunger rod 16 positioned adjacent to the plunger receiving aperture 54 of the stopper adapter 21, the plunger rod 16 is generally within the plunger receiving aperture 54 in the direction along arrow B (FIG. 17). Or is moved axially so that the resilient finger 80 of the plunger rod head 78 is disposed in the plunger receiving opening 74 of the stopper adapter 21. When additional force is applied to the plunger rod 16 to axially move the plunger rod head 78 in the plunger receiving opening 54 in a direction generally along arrow B, the resilient fingers 80 cause the tapered portion of the protruding annular ring 58 to taper. In cooperation with 60, the projecting annular ring 58 passes through the resilient finger 80 of the plunger rod head 78 as the resilient finger 80 of the plunger rod head 78 slides over the tapered portion 60 of the projecting annular ring 58, FIG. And inwardly push or compress in the direction along arrow C (FIG. 18A) until the plunger rod 16 is locked to the stopper adapter 21 as shown in FIGS. After the resilient fingers 80 of the plunger rod head 78 have slid over the tapered portion 60 of the protruding annular ring 58, the resilient fingers 80 are returned to their original as shown in FIGS. 17 and 18A. Return to position. In this position, referring to FIG. 18A, the locking end 62 of the projecting annular ring 58 engages the elastic finger 80 with the projecting annular ring 58 disposed adjacent to the annular groove 84 of the plunger rod head 78. The plunger rod 16 is locked or fixed to the stopper adapter 21 by abutting, contacting, or engaging the toe portion 88. In this configuration, the plunger rod 16 is fixed to the stopper adapter 21 with the elastic finger 80 mechanically locked on the protruding annular ring 58, so that the gap between the plunger rod 16 and the stopper adapter 21 is fixed. Ensure that significant relative movement is prevented. In this way, the plunger rod 16 is adapted to feed the stopper 19 in the syringe barrel 14.

  In another embodiment, the engaging portion 56 of the stopper adapter 21 may comprise a deformable restraining member, eg, an elastic finger, and the engaging portion 76 of the plunger rod 16 secures the plunger rod 16 to the stopper 19. A plunger rod head 78 formed from a rigid, non-bending material may be provided. In another alternative embodiment, the plunger rod 16 can be secured to the syringe barrel 14 via the stopper adapter 21 by screwing the threaded portion of the plunger rod 16 with the threaded portion of the stopper adapter 21. In other embodiments, the plunger rod 16 can be secured to the stopper adapter 21 using ball stops, locking tabs, spring-loaded locking mechanisms, latches, adhesives, or other similar mechanisms. In all embodiments, the plunger rod 16 is locked, fixed or engaged to the stopper adapter 21, i.e. significant relative movement between the plunger rod 16 and the stopper adapter 21 is prevented, The movement of the plunger rod 16 is transmitted to the stopper 19 so that the stopper 19 can be slid between positions in the syringe barrel 14. In other alternative embodiments, the plunger rod 16 and the stopper adapter 21 may be integrally formed, both of which are a plunger assembly positioned in the second compartment 102 of the packaging member 12 and the packaging member 12. And a separate syringe barrel 14 positioned in the first compartment 100.

  In other embodiments, the plunger rod 16 and the stopper adapter 21 can be formed simultaneously, such as by co-extrusion. In an alternative embodiment, the plunger rod 16 and the stopper adapter 21 can be integrally formed as a plunger assembly that can be secured to the syringe barrel 14.

  Referring now to FIGS. 21-23, the plunger rod 16 and syringe barrel 14 are secured together to form the syringe assembly 13, and the user can seal the cap member from the distal end 32 of the syringe barrel 14. 42 can be removed. The user then attaches the distal end 32 of the syringe barrel 14 to a separate needle assembly or IV connection assembly and engages the needle assembly or IV connection assembly with the distal end 32 of the syringe barrel 14 in a known manner. And can be locked. Prior to dispensing the drug, the gas or air trapped in the chamber 36 of the syringe barrel 14 can be expelled in a known manner.

  Next, with reference to FIGS. 21-23, the use of the syringe assembly 13 to expel a fluid, such as a drug, contained within the chamber 36 of the syringe barrel 14 will be described. Movement of the flange 74 of the plunger rod 16 provides an actuating means for moving or sliding the stopper 19 between positions within the syringe barrel 14. For example, the flange 74 may have any shape that allows the user to grip the flange 74 of the plunger rod 16 and actuate it in the front-rear direction.

  The syringe assembly 13 grips the user's thumb on the flange 74 of the plunger rod 16 and the flange 40 of the syringe barrel 14 when it is desired to expel or deliver the drug contained within the syringe barrel 14. , Grasped by the user's finger extending around it. In this way, the syringe assembly 13 is grasped by the user as is well known and well recognized, similar to the operation of a conventional hypodermic syringe. The user then causes a squeezing motion between the thumb on the flange 74 of the plunger rod 16 and the four fingers gripping the flange 40 of the syringe barrel 14, thereby causing the flange 74 of the plunger rod 16 to move. Move toward the proximal end 34 of the syringe barrel 14 generally in the direction along arrow D (FIG. 23). Thus, movement of the stopper 19 in the direction generally along arrow D forces the fluid F (FIG. 3B) contained in the chamber 36 of the syringe barrel 14 to be forced out of the outlet opening 38. That is, movement of the stopper 19 toward the distal end 32 of the syringe barrel 14 reduces the volume of the chamber 36 and pushes fluid F out of the syringe barrel 14. Fluid F may be pumped out of syringe barrel 14 through outlet opening 38 to contact the patient and / or pumped into a separate needle assembly or IV assembly and pumped into the patient's body.

  Referring now to FIGS. 21-23, the use of the syringe assembly 13 to fill the syringe barrel 14 with medication from a separate vial prior to use will be described. The syringe assembly 13 is in a position where the stopper 19 is positioned adjacent to the distal end 32 of the syringe barrel 14 and the needle assembly is locked to the distal end 32 of the syringe barrel 14 and is placed in a vial containing fluid. When it is desired to aspirate or pull a fluid, such as a drug, into the chamber 36 of the syringe barrel 14, the user can move the flange 74 of the plunger rod 16 generally along arrow E (FIG. 23). In addition, travel away from the proximal end 34 of the syringe barrel 14 until a desired amount of fluid is drawn into the chamber 36 of the syringe barrel 14.

  Thus, movement of the stopper 19 in a direction generally along arrow E creates a vacuum within the chamber 36 of the syringe barrel 14. As the user moves the stopper 19 through the plunger rod 16 in a direction generally along arrow E, the user actively increases the volume in the chamber 36 of the syringe barrel 14. The stopper 19 is sized relative to the syringe barrel 14 to provide a sealing engagement with the inner wall of the syringe barrel 14 as described above, and the distal end of the syringe barrel 14 Since the needle assembly locked to 32 is placed in the vial containing the fluid, no gas or air can enter the chamber 36 of the syringe barrel 14, so the user can enter the chamber 36. The same number of gas or air molecules are placed in the chamber 36 as the volume of is actively increased. This reduces the pressure in the chamber 36 of the syringe barrel 14 with respect to the air pressure outside the syringe barrel 14. Thus, a vacuum, i.e., a lower air pressure space, is created and a fluid such as a drug is drawn into the chamber 36 of the syringe barrel 14. Advantageously, the syringe assembly 13 can be used to collect fluid in the chamber 36 of the syringe barrel 14 or to expel fluid from the chamber 36 of the syringe barrel 14.

  24-33 illustrate another exemplary embodiment of the present disclosure. Referring to FIGS. 24 to 33, the syringe packaging system 10 </ b> A includes a packaging member 12 </ b> A, a syringe assembly 13 including a syringe barrel 14 and a detachable plunger rod 16, an oxygen scavenger 18, and a stopper 19. The packaging member 12A contains the syringe barrel 14, plunger rod 16, and oxygen scavenger 18, so that the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and absorbs the oxygen contained in the packaging member 12A. It is adapted to. The syringe packaging system 10A of the present disclosure can also reduce the storage space of the syringe assembly.

  The exemplary embodiment shown in FIGS. 24-33 includes components that are similar to the embodiment shown in FIGS. For the sake of brevity, these similar components and similar steps using the syringe packaging system 10A will not all be described with respect to the embodiment shown in FIGS. In one embodiment, the syringe packaging system 10A is compatible with the syringe assembly 13 and oxygen scavenger 18 shown in FIGS.

  Referring to FIGS. 24-33, the syringe packaging system 10A includes a packaging member 12A formed from a material that is generally oxygen impermeable. In one embodiment, the sealing member 15 (FIG. 2B) can be removably attached to the packaging member 12A. The packaging member 12A is sized and adapted to receive each of the syringe barrel 14, plunger rod 16, and oxygen scavenger 18 therein as will be described in more detail below.

  Referring to FIGS. 24-33, the packaging member 12A includes a first compartment 100A, a second compartment 102A, a third compartment 104A, a first end or upper end 110A, a second end or A lower end 112A and a side wall 114A extending between the upper end 110A and the lower end 112A are provided. The packaging member 12A includes a locking lip 116A at the upper end 110A. Disposed below the locking lip 116A is more than the cross section disposed below the upper tray portion 118A, ie, the compartment portion 120A, so that the step 122A is defined therebetween. An upper tray portion 118A having a cross section with a large area. The partition portion 120A includes an isolation wall 150 disposed such that the isolation wall 150 divides the partition portion 120A into a first partition 100A and a second partition 102A. The isolation wall 150 defines a gas slot 152 that maintains the first compartment 100A and the second compartment 102A in gas communication therewith. The second section 102 </ b> A includes a first raised portion 154 and a second raised portion 156 that is spaced apart from the first raised portion 154. In one embodiment, the first raised portion 154 and the second raised portion 156 are molded on the inner surface 115A of the side wall 114A of the packaging member 12A.

  Referring to FIG. 30, the syringe packaging system 10A includes a partition member 160 that is receivable within the packaging member 12A. The partition member 160 includes notches 162 facing each other, and defines a plurality of gas holes 164.

  All of the components of the syringe packaging system 10A may be made from any known material, preferably from a medical grade polymer.

  Next, the packaging of the syringe barrel 14, the plunger rod 16, and the oxygen scavenger 18 in the packaging member 12A will be described with reference to FIGS. Initially, syringe barrel 14, plunger rod 16 and packaging member 12A are sterilized according to techniques known to those skilled in the art as described above. In some embodiments, the syringe barrel 14 can be pre-filled as described above. Next, as shown in FIG. 31, the oxygen absorber 18 is positioned vertically in the packaging member 12A adjacent to the lower end 112A of the packaging member 12A on the third compartment 104A. 18 is inserted into the side of the third section 104A of the section 120A of the packaging member 12A.

  The partition member 160 is then received within the packaging member 12A as shown in FIGS. In order to secure the partition member 160 in the packaging member 12A, the partition member 160 is positioned in the second section 102A side of the partition portion 120A, and the partition member 160 is generally indicated by an arrow A (FIG. 1). It is inserted into the packaging member 12A in the direction along, or moved axially. In one embodiment, the notch 162 of the partition member 160 provides a feature that holds the partition member 160 in place within the packaging member 12A. As shown in FIGS. 31 and 33, when an additional force is applied to the partition member 160 and the partition member 160 is moved axially in the direction along the arrow A in the packaging member 12A, the partition member 160 is moved. The partition member 160 advances over the first raised portion 154 of the packaging member 12A, that is, slides over the first raised portion 154 and passes the partition member 160 with the first raised portion 154. The first raised portion 154 of the packaging member 12 </ b> A is deformed outward until it is locked with the second raised portion 156. After the partition member 160 slides over the first raised portion 154 of the packaging member 12A, the first raised portion 154 returns to its undeformed or original position. In this position, referring to FIGS. 31 and 33, the first ridge 154 and the second ridge 156 abut, contact or engage the partition member 160, as shown in FIGS. As shown, the partition member 160 is locked or fixed to the packaging member 12 </ b> A between the first raised portion 154 and the second raised portion 156. This configuration ensures that the partition member 160 is secured to the packaging member 12A, thereby preventing significant relative movement between the partition member 160 and the packaging member 12A. Thus, the partition member 160 and the packaging member 12A define the second compartment 102A and the third compartment 104A. The first compartment 100A is sized and adapted to receive the syringe barrel 14 therein, and the second compartment 102A is sized and adapted to receive the plunger rod 16 therein, Third compartment 104A is sized and adapted to receive oxygen scavenger 18 therein. The first compartment 100A, the second compartment 102A, and the third compartment 104A are in gas communication with them. In one embodiment, the gas holes 164 in the partition member 160 and the gas slots 152 in the isolation wall 150 provide gas communication between the compartments 100A, 102A, and 104A. In this way, the packaging member 12A contains the syringe barrel 14, plunger rod 16, and oxygen scavenger 18, and the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and the first compartment 100A of the packaging member 12A. Adapted to absorb oxygen contained in the second compartment 102A and the third compartment 104A.

  In addition, the partition member 160 is secured to the packaging member 12A as described above, thereby preventing significant relative movement between the partition member 160 and the packaging member 12A. The packaging member 12A constitutes a third compartment 104A that fixes the oxygen scavenger 18 within the packaging member 12A so that the oxygen scavenger 18 is prevented from being removed from the packaging member 12A.

  Next, the syringe barrel 14 is inserted into the first compartment 100A of the packaging member 12A, as described above. The syringe barrel 14 is properly inserted into the first compartment 100A of the packaging member 12A, and then the plunger rod 16 is inserted into the second compartment 102A of the packaging member 12A as described above.

  As described above, after the syringe packaging system 10A is properly sterilized, at least a portion of the syringe barrel 14 may be properly inserted into the first compartment 100A of the packaging member 12A. , At least a portion of the plunger rod 16 may be suitably inserted into the second compartment 102A of the wrapping member 12A, and at least a portion of the oxygen scavenger 18 is within the third compartment 104A of the wrapping member 12A. It may be inserted appropriately. Next, the sealing member 15 (FIG. 2B) is used in conjunction with the packaging member 12A to seal the syringe barrel 14, plunger rod 16, and oxygen scavenger 18 in the packaging member 12A. That is, the sealing member 15 and the packaging member 12A together form a leak-proof and protective housing, and the contents of the syringe barrel 14, the plunger rod 16, and the deoxygenation accommodated in the packaging member 12A. It constitutes a substantially impermeable housing that protects the agent 18 and / or maintains a sealed and sterilized environment within the packaging member 12A. In addition, the sealing member 15 and the packaging member 12A together seal the syringe barrel 14, plunger rod 16 and oxygen scavenger 18 within the packaging member 12A to provide oxygen that is external to the syringe packaging system 10A. An additional mechanism for reducing the oxygen concentration in the packaging member 12A is achieved by preventing the from entering the sealed packaging member 12A. The sealing member 15 and the wrapping member 12A together form a sufficient seal over a range of temperature, pressure, and humidity levels.

  Figures 34-44 illustrate another exemplary embodiment of the present disclosure. With reference to FIGS. 15-23 and 34-44, a syringe packaging system 10B includes a packaging member 12B, a syringe assembly 13 including a syringe barrel 14 and a removable plunger rod 16, an oxygen scavenger 18, a stopper 19, A stopper adapter 21 is provided. The packaging member 12B contains the syringe barrel 14, plunger rod 16, and oxygen scavenger 18, so that the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and absorbs the oxygen contained in the packaging member 12B. It is adapted to. The syringe packaging system 10B of the present disclosure can also reduce the storage space of the syringe assembly.

  The exemplary embodiment shown in FIGS. 34-44 includes components that are similar to the embodiment shown in FIGS. For the sake of brevity, these similar components and similar steps using the syringe packaging system 10B will not all be described with respect to the embodiment shown in FIGS. In one embodiment, the syringe packaging system 10B is compatible with the syringe assembly 13 and oxygen scavenger 18 shown in FIGS.

  34-44, the syringe packaging system 10B includes a packaging member 12B formed from a material that is generally oxygen impermeable. In one embodiment, the sealing member 15 (FIG. 2B) can be removably attached to the packaging member 12B. The packaging member 12B is sized and adapted to receive each of the syringe barrel 14, plunger rod 16, and oxygen scavenger 18 therein as will be described in more detail below.

  34 to 44, the packaging member 12B includes a first section 100B, a second section 102B, a third section 104B, a first end or upper end 110B, a second end or A lower end 112B and a side wall 114B extending between the upper end 110B and the lower end 112B are provided. The packaging member 12B includes a locking lip 116B at the upper end 110B. Disposed below the locking lip 116B is more than the cross section disposed below the upper tray portion 118B, ie, the partition portion 120B, such that the step 122B is defined therebetween. An upper tray portion 118B having a cross section with a large area. The partition portion 120B includes a separation wall 170 disposed such that the isolation wall 170 divides the partition portion 120B into a first partition 100B and a second partition 102B. The isolation wall 170 defines a gas slot 172 that maintains the first compartment 100B and the second compartment 102B in gas communication therewith. The second compartment 102B includes an inner wall or oxygen scavenger chamber 174 adjacent to the lower end 112B of the packaging member 12B. The oxygen scavenger chamber 174 is sized to receive the oxygen scavenger 18 therein and forms a third compartment 104B that is adapted. In one embodiment, the first compartment 100B, the second compartment 102B, and the third compartment 104B of the packaging member 12B are formed as a single packaging member component or compartment.

  39-44, the syringe packaging system 10B includes a lid 176 that is receivable within the oxygen scavenger chamber 174 of the packaging member 12B. The lid 176 defines an opening 178. In one embodiment, the lid 176 is sized and adapted to be securable to the oxygen scavenger chamber 174 by an interference fit. The opening 178 of the lid 176 is for efficiently operating the oxygen scavenger 18 accommodated in the oxygen scavenger chamber 174, and the first compartment 100B, the second compartment 102B, and the third compartment 104B. Are maintained in gas communication with them.

  All of the components of the syringe packaging system 10B may be made from any known material, preferably from a medical grade polymer.

  Next, the packaging of the syringe barrel 14, the plunger rod 16, and the oxygen scavenger 18 in the packaging member 12B will be described with reference to FIGS. Initially, the syringe barrel 14, plunger rod 16, and packaging member 12B are sterilized according to techniques known to those skilled in the art as described above. In some embodiments, the syringe barrel 14 can be pre-filled as described above. Next, the oxygen scavenger 18 is inserted into the third compartment 104B of the packaging member 12B, ie, the oxygen scavenger chamber 174, so that the oxygen scavenger 18 is desorbed as shown in FIG. Positioned vertically within oxygen agent chamber 174.

  The lid 176 is then secured to the oxygen scavenger chamber 174 using an interference fit as shown in FIG. This configuration ensures that the lid 176 is secured to the oxygen scavenger chamber 174, thereby preventing significant relative movement between the lid 176 and the oxygen scavenger chamber 174. In this manner, the lid 176 and the oxygen scavenger chamber 174 define the second compartment 102B and the third compartment 104B. The first compartment 100B is sized and adapted to receive the syringe barrel 14 therein, and the second compartment 102B is sized and adapted to receive the plunger rod 16 therein, The third compartment 104B is sized and adapted to receive the oxygen scavenger 18 therein. The first compartment 100B, the second compartment 102B, and the third compartment 104B are in gas communication with them. In this way, the packaging member 12B contains the syringe barrel 14, plunger rod 16, and oxygen scavenger 18, and the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and the first compartment 100B of the packaging member 12B. , And adapted to absorb oxygen contained in the second compartment 102B and the third compartment 104B.

  In addition, a lid 176 is secured to the oxygen scavenger chamber 174 as described above, thereby preventing significant relative movement between the lid 176 and the oxygen scavenger chamber 174. And the oxygen scavenger chamber 174 constitute a third compartment 104B that secures the oxygen scavenger 18 within the packaging member 12B such that the oxygen scavenger 18 is prevented from being removed from the packaging member 12B.

  The syringe barrel 14 is then inserted into the first compartment 100B of the packaging member 12B, as described above. The syringe barrel 14 is properly inserted into the first compartment 100B of the packaging member 12B, and then the plunger rod 16 is inserted into the second compartment 102B of the packaging member 12B as described above.

  As explained above, after the syringe packaging system 10B is properly sterilized, at least a portion of the syringe barrel 14 may be properly inserted into the first compartment 100B of the packaging member 12B. , At least a portion of the plunger rod 16 may be suitably inserted into the second compartment 102B of the packaging member 12B, and at least a portion of the oxygen scavenger 18 is within the third compartment 104B of the packaging member 12B. It may be inserted appropriately. Next, the sealing member 15 (FIG. 2B) is used in conjunction with the packaging member 12B to seal the syringe barrel 14, the plunger rod 16, and the oxygen scavenger 18 in the packaging member 12B. That is, the sealing member 15 and the packaging member 12B together constitute a leak-proof and protective housing, the contents of the syringe barrel 14, the plunger rod 16, and the deoxygenation accommodated in the packaging member 12B. It constitutes a substantially impermeable housing that protects the agent 18 and / or maintains a sealed, sterilized environment within the packaging member 12B. In addition, the sealing member 15 and the packaging member 12B together combine to seal the syringe barrel 14, plunger rod 16, and oxygen scavenger 18 within the packaging member 12B to provide oxygen that is external to the syringe packaging system 10B. An additional mechanism for reducing the oxygen concentration in the packaging member 12B is achieved by preventing from entering the sealed packaging member 12B. The sealing member 15 and the packaging member 12B together form a sufficient seal at a range of temperature, pressure, and humidity levels.

  45-53 illustrate another exemplary embodiment of the present disclosure. Referring to FIGS. 15-23 and 45-53, a syringe packaging system 10C includes a packaging member 12C, a syringe assembly 13 including a syringe barrel 14 and a removable plunger rod 16, an oxygen scavenger 18, a stopper 19, A stopper adapter 21 is provided. The packaging member 12C contains the syringe barrel 14, plunger rod 16, and oxygen scavenger 18, so that the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and absorbs the oxygen contained in the packaging member 12C. Has been adapted. The syringe packaging system 10C of the present disclosure can also reduce the storage space of the syringe assembly.

  The exemplary embodiment shown in FIGS. 45-53 includes components similar to the embodiments shown in FIGS. For the sake of brevity, these similar components and similar steps using the syringe packaging system 10C will not all be described with respect to the embodiment shown in FIGS. In one embodiment, the syringe packaging system 10C is compatible with the syringe assembly 13 and oxygen scavenger 18 shown in FIGS.

  45-53, the syringe packaging system 10C includes a packaging member 12C formed from a material that is generally oxygen impermeable. In one embodiment, the sealing member 15 (FIG. 2B) can be removably attached to the packaging member 12C. The packaging member 12C is sized and adapted to receive each of the syringe barrel 14, plunger rod 16, and oxygen scavenger 18 therein as will be described in further detail below.

  45 to 53, the packaging member 12C includes a first compartment 100C, a second compartment 102C, a third compartment 104C, a first end or upper end 110C, a second end or A lower end 112C and a side wall 114C extending between the upper end 110C and the lower end 112C are provided. The packaging member 12C includes a locking lip 116C at the upper end 110C. Disposed below the locking lip 116C is more than the cross section disposed below the upper tray portion 118C, ie, the compartment portion 120C, so that the step 122C is defined therebetween. An upper tray portion 118C having a cross section with a large area. Upper tray portion 118C receives and supports flange 40 of syringe barrel 14 and flange 74 of plunger rod 16 as will be described in more detail below. The inner surface of the side wall 114C of the packaging member 12C includes opposing angular ribs 180 that extend along the longitudinal axis of the packaging member 12C. Opposing angular ribs 180 form vertices 182 as shown in FIG.

  In one embodiment, the angular ribs 180 divide the compartment portion 120C into a first compartment 100C and a second compartment 102C as shown in FIG. In one embodiment, the apex 182 of the angular rib 180 divides the compartment portion 120C into a second compartment 102C and a third compartment 104C as shown in FIG. The first compartment 100C, the second compartment 102C, and the third compartment 104C are in gas communication with them. In one embodiment, the first compartment 100C, the second compartment 102C, and the third compartment 104C of the packaging member 12C are formed as a single packaging member component or compartment.

  45 and 46, the upper tray portion 118C includes a plunger rod support member 184 on the circumference of the second compartment 102C and a syringe barrel support member 186 on the circumference of the first compartment 100C. The plunger rod support member 184 implements a further securing mechanism for engaging the plunger rod 16 to secure the plunger rod 16 in the second compartment 102C of the packaging member 12C. For example, referring to FIGS. 51 and 52, in one embodiment, the lower surface of the flange 74 of the plunger rod 16 engages the plunger rod support member 184 when the plunger rod 16 is inserted into the second compartment 102C. The plunger rod 16 is fixed and stabilized in the packaging member 12C. The syringe barrel support member 186 provides a further securing mechanism for engaging the syringe barrel 14 to secure the syringe barrel 14 within the first compartment 100C of the packaging member 12C. For example, referring to FIGS. 51 and 52, in one embodiment, when the syringe barrel 14 is inserted into the first compartment 100C, the flange 40 of the syringe barrel 14 engages the syringe barrel support member 186 and the syringe barrel is engaged. 14 is fixed in the packaging member 12C. In one embodiment, the syringe barrel support member 186 implements a mechanism that allows the syringe barrel 14 to be positioned within the packaging member 12C such that the flat end of the flange 40 is along one direction. . In one embodiment, the syringe barrel support member 186 acts as an anti-nesting mechanism during bulk packaging.

  45 and 46, the lower portion or lower end 112C of the packaging member 12C tapers from the third compartment 104C to the first compartment 100C side. In this way, the overall size of the packaging member 12C is reduced.

  All of the components of the syringe packaging system 10C may be made from any known material, preferably from a medical grade polymer.

  Next, the packaging of the syringe barrel 14, the plunger rod 16, and the oxygen scavenger 18 in the packaging member 12C will be described with reference to FIGS. Initially, syringe barrel 14, plunger rod 16 and packaging member 12C are sterilized according to techniques known to those skilled in the art as described above. In some embodiments, the syringe barrel 14 can be pre-filled as described above.

  Next, the oxygen scavenger 18 is received in the third compartment 104C of the packaging member 12C such that the oxygen scavenger 18 is positioned vertically within the third compartment 104C, as shown in FIG. It is done. In order to secure the oxygen scavenger 18 in the third compartment 104C of the packaging member 12C, is the oxygen scavenger 18 generally inserted into the packaging member 12C in the direction along arrow A (FIG. 1)? Or moved axially. As shown in FIG. 53, when additional force is applied to the oxygen scavenger 18 and axially moves the oxygen scavenger 18 in a direction generally along arrow A within the packaging member 12C, the oxygen scavenger 18, the oxygen absorber 18 advances beyond the apex 182 of the square rib 180 of the packaging member 12C, that is, slides over the apex 182, passing the oxygen absorber 18 in the third compartment of the packaging member 12C. The vertex 182 of the square rib 180 of the packaging member 12C is deformed outward until it is locked in 104C. As the oxygen scavenger 18 slides over the vertices 182 of the corner ribs 180 of the packaging member 12C, the vertices 182 of the corner ribs 180 return to their undeformed or original positions. In this position, the apex 182 of the square rib 180 abuts, contacts or engages the oxygen scavenger 18 to lock the oxygen scavenger 18 within the third compartment 104C of the packaging member 12C, or Can be fixed. This configuration ensures that the packaging member 12C forms a third compartment 104C that secures the oxygen scavenger 18 within the packaging member 12C such that the scavenger 18 is prevented from being removed from the packaging member 12C. To. This configuration also ensures that the oxygen scavenger 18 is maintained in the third compartment 104C and cannot slide toward the first compartment 100C.

  The syringe packaging system 10C comprises a system with minimal or no interference between the packaging member 12C and the oxygen scavenger 18 after the oxygen scavenger 18 is properly positioned in the third compartment 104C. . In this way, there is very little or no stress on the wrapping member 12C and / or the oxygen scavenger 18.

  The syringe barrel 14 is then inserted into the first compartment 100C of the packaging member 12C as described above. The syringe barrel 14 is properly inserted into the first compartment 100C of the packaging member 12C, and then the plunger rod 16 is inserted into the second compartment 102C of the packaging member 12C as described above.

  In this way, the packaging member 12C contains the syringe barrel 14, plunger rod 16, and oxygen scavenger 18, and the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and the first compartment 100C of the packaging member 12C. Adapted to absorb oxygen contained in the second compartment 102C and the third compartment 104C.

  As described above, after the syringe packaging system 10C is properly sterilized, at least a portion of the syringe barrel 14 may be properly inserted into the first compartment 100C of the packaging member 12C. , At least a portion of the plunger rod 16 may be suitably inserted into the second compartment 102C of the packaging member 12C and at least a portion of the oxygen scavenger 18 is within the third compartment 104C of the packaging member 12C. It may be inserted appropriately. Next, the sealing member 15 (FIG. 2B) is used in conjunction with the packaging member 12C to seal the syringe barrel 14, the plunger rod 16, and the oxygen scavenger 18 in the packaging member 12C. That is, the sealing member 15 and the packaging member 12C together form a leak-proof and protective housing, and the contents of the syringe barrel 14, the plunger rod 16, and the deoxygenation accommodated in the packaging member 12C. It constitutes a substantially impermeable housing that protects the agent 18 and / or maintains a sealed and sterilized environment within the packaging member 12C. In addition, the sealing member 15 and the packaging member 12C together combine to seal the syringe barrel 14, plunger rod 16, and oxygen scavenger 18 within the packaging member 12C to provide oxygen that is external to the syringe packaging system 10C. An additional mechanism for reducing the oxygen concentration in the packaging member 12C is achieved by preventing from entering the sealed packaging member 12C. The sealing member 15 and the wrapping member 12C together form a sufficient seal over a range of temperature, pressure, and humidity levels.

  54-61 illustrate another exemplary embodiment of the present disclosure. With reference to FIGS. 15-23 and 54-61, a syringe packaging system 10D includes a packaging member 12D, a syringe assembly 13 including a syringe barrel 14 and a removable plunger rod 16, an oxygen scavenger 18, a stopper 19, and A stopper adapter 21 is provided. The packaging member 12D encloses the syringe barrel 14, plunger rod 16, and oxygen scavenger 18, so that the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and absorbs the oxygen contained in the packaging member 12D. It is adapted to. The syringe packaging system 10D of the present disclosure can also reduce the storage space of the syringe assembly.

  The exemplary embodiment shown in FIGS. 54-61 includes components that are similar to the embodiment shown in FIGS. For the sake of brevity, these similar components and similar steps using the syringe packaging system 10D will not all be described with respect to the embodiment shown in FIGS. In one embodiment, the syringe packaging system 10D is compatible with the syringe assembly 13 and oxygen scavenger 18 shown in FIGS.

  54-61, the syringe packaging system 10D includes a packaging member 12D formed from a material that is generally oxygen impermeable. In one embodiment, the sealing member 15 (FIG. 2B) can be removably attached to the packaging member 12D. The packaging member 12D is sized and adapted to receive each of the syringe barrel 14, plunger rod 16, and oxygen scavenger 18 therein as will be described in more detail below.

  54 to 61, the packaging member 12D includes a first compartment 100D, a second compartment 102D, a third compartment 104D, a first end or upper end 110D, a second end or A lower end 112D and a side wall 114D extending between the upper end 110D and the lower end 112D are provided. The packaging member 12D includes a locking lip portion 116D at the upper end 110D. Disposed below the locking lip 116D is more than the cross section disposed below the upper tray portion 118D, ie, the compartment portion 120D, so that the step 122D is defined therebetween. An upper tray portion 118D having a cross section with a large area. Upper tray portion 118D receives and supports flange 40 of syringe barrel 14 and flange 74 of plunger rod 16. The inner surface of the side wall 114D of the packaging member 12D includes opposing fin elements 190 that extend along the longitudinal axis of the packaging member 12D. Opposing fin element 190 includes a retracting portion 192, an upper portion 194, and a lower portion 196.

  In one embodiment, the fin element 190 divides the compartment portion 120D into a first compartment 100D and a second compartment 102D as shown in FIG. In one embodiment, the upper portion 194 and the lower portion 196 of the fin element 190 divide the compartment portion 120D into a second compartment 102D and a third compartment 104D as shown in FIG. The first compartment 100D, the second compartment 102D, and the third compartment 104D are in gas communication with them. In one embodiment, the first compartment 100D, the second compartment 102D, and the third compartment 104D of the packaging member 12D are formed as a single packaging member component or compartment.

  Referring to FIGS. 54 and 55, the lower portion or lower end 112D of the packaging member 12D tapers from the third compartment 104D to the first compartment 100D side. In this way, the overall size of the packaging member 12D is reduced.

  All of the components of the syringe packaging system 10D may be made from any known material, preferably from a medical grade polymer.

  Next, the packaging of the syringe barrel 14, the plunger rod 16, and the oxygen scavenger 18 in the packaging member 12D will be described with reference to FIGS. Initially, the syringe barrel 14, plunger rod 16, and packaging member 12D are sterilized according to techniques known to those skilled in the art as described above. In some embodiments, the syringe barrel 14 can be pre-filled as described above.

  The oxygen scavenger 18 is then received in the third compartment 104D of the packaging member 12D such that the oxygen scavenger 18 is positioned vertically within the third compartment 104D. In order to fix the oxygen scavenger 18 in the third compartment 104D of the packaging member 12D, is the oxygen scavenger 18 generally inserted into the packaging member 12D in the direction along arrow A (FIG. 1)? Or moved axially. The retraction portion 192 of the fin element 190 includes a retraction surface that helps guide and center the oxygen scavenger 18 within the packaging member 12D. When additional force is applied to the oxygen scavenger 18 and axially moves the oxygen scavenger 18 in a direction generally along arrow A within the packaging member 12D, the oxygen scavenger 18 will be The fin is advanced over the upper portion 194 of the 12D fin element 190, i.e., sliding past the upper portion 194 and locking the oxygen scavenger 18 within the third compartment 104D of the packaging member 12D. A part of the element 190 is deformed outward. As the oxygen scavenger 18 slides over the upper portion 194 of the fin element 190 of the packaging member 12D, the fin elements 190 return to their undeformed or original positions. In this position, the fin element 190 abuts, contacts or engages with the oxygen scavenger 18, and the oxygen scavenger 18 is attached to the first of the packaging member 12D by an interference fit between the fin element 190 and the oxygen scavenger 18. It can be locked or fixed in the three compartments 104D. This configuration ensures that the packaging member 12D forms a third compartment 104D that secures the oxygen scavenger 18 within the packaging member 12D such that the oxygen scavenger 18 is prevented from being removed from the packaging member 12D. To. This configuration also ensures that the oxygen scavenger 18 is maintained in the third compartment 104D and cannot slide toward the first compartment 100D.

  The syringe barrel 14 is then inserted into the first compartment 100D of the packaging member 12D as described above. The syringe barrel 14 is properly inserted into the first compartment 100D of the packaging member 12D, and then the plunger rod 16 is inserted into the second compartment 102D of the packaging member 12D as described above.

  In this way, the packaging member 12D contains the syringe barrel 14, plunger rod 16, and oxygen scavenger 18, and the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and the first compartment 100D of the packaging member 12D. Adapted to absorb oxygen contained in the second compartment 102D and the third compartment 104D.

  62-70 illustrate another exemplary embodiment of the present disclosure. With reference to FIGS. 15-23 and 62-70, a syringe packaging system 10E includes a packaging member 12E, a syringe assembly 13 including a syringe barrel 14 and a removable plunger rod 16, an oxygen scavenger 18, a stopper 19, and A stopper adapter 21 is provided. The packaging member 12E contains the syringe barrel 14, plunger rod 16, and oxygen scavenger 18, so that the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and absorbs the oxygen contained in the packaging member 12E. It is adapted to. The syringe packaging system 10E of the present disclosure can also reduce the storage space of the syringe assembly.

  The exemplary embodiment shown in FIGS. 62-70 includes components that are similar to the embodiment shown in FIGS. For the sake of brevity, these similar components and similar steps using the syringe packaging system 10E will not all be described with respect to the embodiment shown in FIGS. In one embodiment, the syringe packaging system 10E is compatible with the syringe assembly 13 and oxygen scavenger 18 shown in FIGS.

  62-70, the syringe packaging system 10E includes a packaging member 12E formed from a material that is generally oxygen impermeable. In one embodiment, the sealing member 15 (FIG. 2B) can be removably attached to the packaging member 12E. The packaging member 12E is sized and adapted to receive each of the syringe barrel 14, plunger rod 16, and oxygen scavenger 18.

  62 to 70, the packaging member 12E includes a first compartment 100E, a second compartment 102E, a third compartment 104E, a first end or upper end 110E, a second end or A lower end 112E and a side wall 114E extending between the upper end 110E and the lower end 112E are provided. The packaging member 12E includes a locking lip 116E at the upper end 110E. Disposed below the locking lip 116E is more than the cross section disposed below the upper tray portion 118E, ie, the compartment portion 120E, so that the step 122E is defined therebetween. An upper tray portion 118E having a cross section with a large area. Upper tray portion 118E receives and supports flange 40 of syringe barrel 14 and flange 74 of plunger rod 16.

  The compartment portion 120E includes a syringe barrel container 200, a plunger rod, and an oxygen scavenger container 202. Plunger rod and oxygen scavenger container 202 is sized to receive plunger rod 16 and oxygen scavenger 18 therein, respectively, and form a second compartment 102E and a third compartment 104E that are adapted. . The syringe barrel container 200 is sized and configured to receive the syringe barrel 14 therein to form a first compartment 100E that is adapted. In one embodiment, the first compartment 100E, the second compartment 102E, and the third compartment 104E of the packaging member 12E are formed as a single packaging member component or compartment. The syringe barrel container 200 and the plunger rod and oxygen scavenger container 202 are gases that maintain the first compartment 100E, the second compartment 102E, and the third compartment 104E in gas communication with them. A slot 206 is defined. The inner surface of the plunger rod and oxygen absorber container 202 includes a rib 204 extending along the longitudinal axis of the plunger rod and oxygen absorber container 202 of the packaging member 12E.

  All of the components of the syringe packaging system 10E may be made from any known material, preferably from a medical grade polymer.

  Next, the packaging of the syringe barrel 14, the plunger rod 16, and the oxygen scavenger 18 in the packaging member 12E will be described with reference to FIGS. Initially, the syringe barrel 14, plunger rod 16, and packaging member 12E are sterilized according to techniques known to those skilled in the art as described above. In some embodiments, the syringe barrel 14 can be pre-filled as described above.

  The oxygen scavenger 18 is then received within the third compartment 104E of the packaging member 12E, ie, the plunger rod and oxygen scavenger container 202, whereby the oxygen scavenger 18 is shown in FIG. So as to be positioned vertically within the plunger rod and oxygen absorber container 202. In order to secure the oxygen scavenger 18 in the third compartment 104E of the packaging member 12E, the oxygen scavenger 18 is generally connected to the plunger rod and oxygen scavenging of the packaging member 12E in the direction along arrow A (FIG. 1). It is inserted into the agent container 202 or moved axially. As additional force is applied to the oxygen scavenger 18 and axially moves the oxygen scavenger 18 in a direction generally along arrow A within the plunger rod of the packaging member 12E and the oxygen scavenger container 202, the oxygen scavenger 18 Will deform the ribs 204 outward until the oxygen scavenger 18 advances to the plunger rod of the packaging member 12E and the lower portion of the oxygen scavenger container 202. In this position, the rib 204 abuts, contacts or engages the oxygen scavenger 18, and the oxygen scavenger 18 is attached to the third of the packaging member 12E by an interference fit between the rib 204 and the oxygen scavenger 18. The plunger rod of the compartment 104E and the oxygen scavenger container 202 can be locked or secured. This configuration ensures that the packaging member 12E forms a third compartment 104E that secures the oxygen scavenger 18 within the packaging member 12E such that the oxygen scavenger 18 is prevented from being removed from the packaging member 12E. To. This configuration also ensures that the oxygen scavenger 18 is maintained in the third compartment 104E and cannot slide toward the first compartment 100E. Next, the syringe barrel 14 is inserted into the syringe barrel container 200 of the packaging member 12E as shown in FIG. Next, the plunger rod 16 is inserted into the plunger rod of the packaging member 12E and the oxygen scavenger container 202 as shown in FIG.

  In this way, the wrapping member 12E contains the syringe barrel 14, plunger rod 16, and oxygen scavenger 18, and the oxygen scavenger 18 draws oxygen from the syringe barrel 14 and the first compartment 100E of the packaging member 12E. Adapted to absorb oxygen contained in the second compartment 102E and the third compartment 104E.

  While exemplary embodiments have been described above, those skilled in the art will recognize that changes and modifications can be made to these embodiments without departing from the scope and spirit of the invention as defined by the claims. You will understand.

Claims (32)

A syringe packaging system,
A syringe barrel,
A plunger rod;
An oxygen scavenger;
A packaging member that defines a first section, a second section, and a third section that are separated from each other , wherein the first section, the second section, and the third section are In gas communication, the first compartment has a structure for receiving the syringe barrel therein, the second compartment has a structure for receiving the plunger rod therein, and the third compartment is A packaging member having a structure for receiving the oxygen scavenger therein,
The packaging member encloses the syringe barrel, the plunger rod, and the oxygen scavenger, and the oxygen scavenger draws oxygen out of the syringe barrel, the first compartment of the packaging member, the second syringe packaging system partition, and that characterized the Turkey to absorb oxygen contained in at least one of said third section to the.   The syringe barrel includes a first end, a second end, and a sidewall extending therebetween and defining a chamber having an interior, the syringe barrel being the interior of the chamber. The syringe packaging system according to claim 1, further comprising a stopper slidably disposed therein.   The syringe packaging system according to claim 2, wherein the plunger rod is engageable with a part of the stopper.   The syringe packaging system of claim 2, further comprising a fluid disposed within the chamber of the syringe barrel.   The packaging member contains the syringe barrel, the plunger rod, and the oxygen scavenger, and the oxygen scavenger is adapted to draw oxygen from the fluid disposed in the chamber of the syringe barrel. The syringe packaging system according to claim 4.   The syringe packaging system of claim 5, wherein the oxygen scavenger is adapted to draw oxygen from the fluid disposed in the chamber through the stopper.   The syringe packaging system of claim 5, wherein the oxygen scavenger is adapted to draw oxygen from the fluid disposed in the chamber through the syringe barrel.   The syringe according to claim 1, wherein the packaging member includes a sealing member, and the packaging member and the sealing member contain the syringe barrel, the plunger rod, and the oxygen scavenger. Packaging system.   The syringe packaging system of claim 1, wherein the first compartment, the second compartment, and the third compartment are formed as part of a single compartment.   A partition member that can be received in the packaging member, wherein the partition member and the packaging member define the first compartment, the second compartment, and the third compartment; The syringe packaging system according to claim 1. 11. The partition member defines a plurality of gas holes that allow gas communication between the first section, the second section, and the third section. Syringe packaging system according to.   The syringe packaging system of claim 10, wherein the packaging member comprises side walls defining opposing slots for receiving the partition members.   The syringe packaging system according to claim 1, wherein the packaging member comprises at least one rib for engaging the oxygen scavenger to secure the oxygen scavenger in the packaging member.   The syringe packaging system according to claim 1, wherein the packaging member includes a support member for engaging the plunger rod so as to fix the plunger rod in the packaging member.   The syringe packaging system according to claim 1, wherein the packaging member includes a support member for engaging the syringe barrel so as to fix the syringe barrel in the packaging member.   The syringe packaging system according to claim 1, wherein the packaging member includes a tapered portion of a side wall for fixing the oxygen scavenger in the packaging member.   The packaging member includes a first protrusion and a second protrusion, and the partition member is at least partially receivable between the first protrusion and the second protrusion. The syringe packaging system according to claim 10.   The syringe packaging system according to claim 1, wherein the packaging member includes a fin for engaging the oxygen scavenger so as to fix the oxygen scavenger in the packaging member.   The said packaging member is provided with the inner wall for fixing the said oxygen scavenger in the said packaging member, and the lid | cover which has an opening, The said lid | cover can be fixed to the said inner wall. Syringe packaging system.   The syringe packaging system of claim 1, wherein the oxygen scavenger comprises a polyolefin-based material. A syringe packaging system,
A syringe barrel having a first end, a second end, and a sidewall extending therebetween and defining a chamber having an interior;
A stopper slidably disposed within the interior of the chamber of the syringe barrel;
A flow body disposed in said chamber of said syringe barrel,
A plunger rod that is engageable with a portion of the stopper;
An oxygen scavenger;
Formed of a material that is acid Motofu permeable, first compartment of which are divided from one another, the second compartment, and a third compartment a packaging member defining the said first compartment, said second And the third compartment has a structure for receiving the syringe barrel therein, and the second compartment has a structure for receiving the plunger rod therein. And the third compartment comprises a packaging member having a structure for receiving the oxygen scavenger therein,
At least one of the syringe barrel and the stopper is formed from an oxygen permeable material; and
The packaging member contains the syringe barrel, the plunger rod, and the oxygen scavenger, and the oxygen scavenger draws oxygen from the fluid disposed in the chamber of the syringe barrel, and the packaging member syringe packaging system comprising a benzalkonium absorb oxygen contained in the inside.   The syringe packaging system of claim 21, wherein the oxygen scavenger is adapted to draw oxygen from the fluid disposed in the chamber through the stopper.   The syringe packaging system of claim 21, wherein the oxygen scavenger is adapted to draw oxygen from the fluid disposed in the chamber through the syringe barrel.   The syringe according to claim 21, wherein the packaging member includes a sealing member, and the packaging member and the sealing member contain the syringe barrel, the plunger rod, and the oxygen scavenger. Packaging system.   The syringe packaging system of claim 21, wherein the first compartment, the second compartment, and the third compartment are formed as part of a single compartment.   The syringe packaging system according to claim 21, wherein the packaging member is formed of a polyester material or a polyamide material. A syringe packaging system,
A syringe barrel,
An oxygen scavenger;
A packaging member which defines the second ward image that first compartment and separated, said first compartment and said second compartment through gaseous communication, the first compartment the syringe therein A packaging member having a structure for receiving a barrel, wherein the second compartment has a structure for receiving the oxygen scavenger therein;
Syringe packaging system said packaging member containment and the oxygen absorber and the syringe barrel, the oxygen scavenger, characterized by a score draw out oxygen from the syringe barrel.   The syringe barrel includes a first end, a second end, and a sidewall extending therebetween and defining a chamber having an interior, the syringe barrel being the interior of the chamber. 28. The syringe packaging system according to claim 27, further comprising a stopper slidably disposed therein.   30. The syringe packaging system of claim 28, further comprising a fluid disposed within the chamber of the syringe barrel.   The wrapping member contains the syringe barrel and the oxygen scavenger, and the oxygen scavenger is adapted to draw oxygen from the fluid disposed in the chamber of the syringe barrel. 30. A syringe packaging system according to claim 29.   31. The syringe packaging system of claim 30, wherein the oxygen scavenger is adapted to draw oxygen from the fluid disposed in the chamber through the stopper.   31. The syringe packaging system of claim 30, wherein the oxygen scavenger is adapted to draw oxygen from the fluid disposed in the chamber through the syringe barrel.

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