JP6271318B2 - Cellulose-based water-soluble thickener - Google Patents
Cellulose-based water-soluble thickener Download PDFInfo
- Publication number
- JP6271318B2 JP6271318B2 JP2014067659A JP2014067659A JP6271318B2 JP 6271318 B2 JP6271318 B2 JP 6271318B2 JP 2014067659 A JP2014067659 A JP 2014067659A JP 2014067659 A JP2014067659 A JP 2014067659A JP 6271318 B2 JP6271318 B2 JP 6271318B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- cellulose
- acid
- fine
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229920002678 cellulose Polymers 0.000 title claims description 137
- 239000001913 cellulose Substances 0.000 title claims description 136
- 239000002562 thickening agent Substances 0.000 title claims description 30
- 239000000835 fiber Substances 0.000 claims description 56
- 239000000203 mixture Substances 0.000 claims description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 39
- 229910052698 phosphorus Inorganic materials 0.000 claims description 28
- 239000011574 phosphorus Substances 0.000 claims description 27
- 239000002537 cosmetic Substances 0.000 claims description 19
- 239000003921 oil Substances 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
- 239000013538 functional additive Substances 0.000 claims description 11
- 239000003960 organic solvent Substances 0.000 claims description 9
- 150000001768 cations Chemical class 0.000 claims description 8
- 239000010419 fine particle Substances 0.000 claims description 8
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 5
- 239000002781 deodorant agent Substances 0.000 claims description 5
- 239000004094 surface-active agent Substances 0.000 claims description 5
- 239000003205 fragrance Substances 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 239000004909 Moisturizer Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 230000001333 moisturizer Effects 0.000 claims description 2
- 239000003002 pH adjusting agent Substances 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 4
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 description 131
- -1 hydrogen ions Chemical class 0.000 description 63
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 33
- 229920001296 polysiloxane Polymers 0.000 description 30
- 239000002002 slurry Substances 0.000 description 27
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 26
- 238000000034 method Methods 0.000 description 24
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 20
- 239000002994 raw material Substances 0.000 description 20
- 239000002253 acid Substances 0.000 description 18
- 229920003043 Cellulose fiber Polymers 0.000 description 17
- 229920001131 Pulp (paper) Polymers 0.000 description 17
- 239000007864 aqueous solution Substances 0.000 description 17
- 150000003839 salts Chemical class 0.000 description 17
- 150000001875 compounds Chemical class 0.000 description 15
- 150000002430 hydrocarbons Chemical group 0.000 description 14
- 229940126062 Compound A Drugs 0.000 description 13
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 13
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 13
- 235000014113 dietary fatty acids Nutrition 0.000 description 13
- 239000000194 fatty acid Substances 0.000 description 13
- 229930195729 fatty acid Natural products 0.000 description 13
- 239000011780 sodium chloride Substances 0.000 description 13
- 230000002378 acidificating effect Effects 0.000 description 12
- 239000003513 alkali Substances 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 12
- 239000002655 kraft paper Substances 0.000 description 11
- 235000019198 oils Nutrition 0.000 description 11
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 10
- 238000005259 measurement Methods 0.000 description 10
- 239000004166 Lanolin Substances 0.000 description 9
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- 239000000839 emulsion Substances 0.000 description 9
- 235000019388 lanolin Nutrition 0.000 description 9
- 229940039717 lanolin Drugs 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 239000006071 cream Substances 0.000 description 7
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 7
- 239000000284 extract Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
- 230000018044 dehydration Effects 0.000 description 6
- 238000006297 dehydration reaction Methods 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 150000004665 fatty acids Chemical class 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 150000001298 alcohols Chemical class 0.000 description 5
- 239000012670 alkaline solution Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 238000002441 X-ray diffraction Methods 0.000 description 4
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- 235000010323 ascorbic acid Nutrition 0.000 description 4
- 239000011668 ascorbic acid Substances 0.000 description 4
- 229960005070 ascorbic acid Drugs 0.000 description 4
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 4
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 4
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 238000007385 chemical modification Methods 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 125000000524 functional group Chemical group 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 235000021317 phosphate Nutrition 0.000 description 4
- 210000002826 placenta Anatomy 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 239000013055 pulp slurry Substances 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 125000003944 tolyl group Chemical group 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 244000025254 Cannabis sativa Species 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 3
- 239000005708 Sodium hypochlorite Substances 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 150000001340 alkali metals Chemical class 0.000 description 3
- 206010061592 cardiac fibrillation Diseases 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 230000002600 fibrillogenic effect Effects 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 238000005342 ion exchange Methods 0.000 description 3
- 239000002563 ionic surfactant Substances 0.000 description 3
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 3
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 3
- 239000011122 softwood Substances 0.000 description 3
- 229940032094 squalane Drugs 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- TZZAKSLHHIJRLL-UHFFFAOYSA-N 4-hydroxy-3-methoxybenzamide Chemical compound COC1=CC(C(N)=O)=CC=C1O TZZAKSLHHIJRLL-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
- 235000018185 Betula X alpestris Nutrition 0.000 description 2
- 235000018212 Betula X uliginosa Nutrition 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 description 2
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 102100031868 DNA excision repair protein ERCC-8 Human genes 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 2
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 2
- 101000920778 Homo sapiens DNA excision repair protein ERCC-8 Proteins 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- 241000218657 Picea Species 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229920000388 Polyphosphate Polymers 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 229920002125 Sokalan® Chemical class 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 229930003270 Vitamin B Natural products 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000000862 absorption spectrum Methods 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 2
- 150000008041 alkali metal carbonates Chemical class 0.000 description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 2
- 229910000318 alkali metal phosphate Inorganic materials 0.000 description 2
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 2
- 229910000316 alkaline earth metal phosphate Inorganic materials 0.000 description 2
- 150000001342 alkaline earth metals Chemical class 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 229960000458 allantoin Drugs 0.000 description 2
- 235000011399 aloe vera Nutrition 0.000 description 2
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 239000001099 ammonium carbonate Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 2
- 229950004580 benzyl nicotinate Drugs 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 2
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 235000009120 camo Nutrition 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 235000005607 chanvre indien Nutrition 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 2
- KSMVZQYAVGTKIV-UHFFFAOYSA-N decanal Chemical compound CCCCCCCCCC=O KSMVZQYAVGTKIV-UHFFFAOYSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 229960003720 enoxolone Drugs 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- 239000000118 hair dye Substances 0.000 description 2
- 239000011487 hemp Substances 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 150000004679 hydroxides Chemical class 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229940099367 lanolin alcohols Drugs 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- 125000001038 naphthoyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 description 2
- HCZKYJDFEPMADG-UHFFFAOYSA-N nordihydroguaiaretic acid Chemical compound C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000000123 paper Substances 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 230000000865 phosphorylative effect Effects 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 2
- 239000001205 polyphosphate Substances 0.000 description 2
- 235000011176 polyphosphates Nutrition 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 229960003975 potassium Drugs 0.000 description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 235000017709 saponins Nutrition 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 239000002453 shampoo Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical group C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- VDZOOKBUILJEDG-UHFFFAOYSA-M tetrabutylammonium hydroxide Chemical compound [OH-].CCCC[N+](CCCC)(CCCC)CCCC VDZOOKBUILJEDG-UHFFFAOYSA-M 0.000 description 2
- WGTYBPLFGIVFAS-UHFFFAOYSA-M tetramethylammonium hydroxide Chemical compound [OH-].C[N+](C)(C)C WGTYBPLFGIVFAS-UHFFFAOYSA-M 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 229930003799 tocopherol Natural products 0.000 description 2
- 235000010384 tocopherol Nutrition 0.000 description 2
- 239000011732 tocopherol Substances 0.000 description 2
- 229960001295 tocopherol Drugs 0.000 description 2
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 2
- 229960000401 tranexamic acid Drugs 0.000 description 2
- TWQULNDIKKJZPH-UHFFFAOYSA-K trilithium;phosphate Chemical compound [Li+].[Li+].[Li+].[O-]P([O-])([O-])=O TWQULNDIKKJZPH-UHFFFAOYSA-K 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- 235000019801 trisodium phosphate Nutrition 0.000 description 2
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- 235000019166 vitamin D Nutrition 0.000 description 2
- 239000011710 vitamin D Substances 0.000 description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 229940046008 vitamin d Drugs 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 229930007845 β-thujaplicin Natural products 0.000 description 2
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 1
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 1
- NZGWDASTMWDZIW-MRVPVSSYSA-N (+)-pulegone Chemical compound C[C@@H]1CCC(=C(C)C)C(=O)C1 NZGWDASTMWDZIW-MRVPVSSYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- PIGTXFOGKFOFTO-FVFWYJKVSA-N (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-carboxy-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O([C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)C[C@@H](O)[C@]1(CCC(C[C@H]14)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O PIGTXFOGKFOFTO-FVFWYJKVSA-N 0.000 description 1
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- RXZBMPWDPOLZGW-HEWSMUCTSA-N (Z)-roxithromycin Chemical group O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N\OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-HEWSMUCTSA-N 0.000 description 1
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- OOSZCNKVJAVHJI-UHFFFAOYSA-N 1-[(4-fluorophenyl)methyl]piperazine Chemical compound C1=CC(F)=CC=C1CN1CCNCC1 OOSZCNKVJAVHJI-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 description 1
- RRZWKUGIZRDCPB-UHFFFAOYSA-N 2,3-dihydroxypropyl hexanoate Chemical compound CCCCCC(=O)OCC(O)CO RRZWKUGIZRDCPB-UHFFFAOYSA-N 0.000 description 1
- ZXDDPOHVAMWLBH-UHFFFAOYSA-N 2,4-Dihydroxybenzophenone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=CC=C1 ZXDDPOHVAMWLBH-UHFFFAOYSA-N 0.000 description 1
- DJCYDDALXPHSHR-UHFFFAOYSA-N 2-(2-propoxyethoxy)ethanol Chemical compound CCCOCCOCCO DJCYDDALXPHSHR-UHFFFAOYSA-N 0.000 description 1
- XPALGXXLALUMLE-UHFFFAOYSA-N 2-(dimethylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N(C)C)C(O)=O XPALGXXLALUMLE-UHFFFAOYSA-N 0.000 description 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
- KNUPSOXBESCJLY-UHFFFAOYSA-N 2-methoxy-1-phenylhexan-1-one Chemical compound CCCCC(OC)C(=O)C1=CC=CC=C1 KNUPSOXBESCJLY-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- AHDXKQAZDADIGD-UHFFFAOYSA-N 2-propan-2-ylhexadecanoic acid Chemical class CCCCCCCCCCCCCCC(C(C)C)C(O)=O AHDXKQAZDADIGD-UHFFFAOYSA-N 0.000 description 1
- QUJHRAJAGNMYKJ-UHFFFAOYSA-N 2-propan-2-yloctadecanoic acid Chemical class CCCCCCCCCCCCCCCCC(C(C)C)C(O)=O QUJHRAJAGNMYKJ-UHFFFAOYSA-N 0.000 description 1
- CKPOABDCSSXDCY-UHFFFAOYSA-N 2-propan-2-yltetradecanoic acid Chemical class CCCCCCCCCCCCC(C(C)C)C(O)=O CKPOABDCSSXDCY-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- XUCWDRXDOBIKIO-UHFFFAOYSA-N 3-(oxomethylidene)pyrrolidin-2-one Chemical compound O=C=C1CCNC1=O XUCWDRXDOBIKIO-UHFFFAOYSA-N 0.000 description 1
- 125000004975 3-butenyl group Chemical group C(CC=C)* 0.000 description 1
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 1
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 description 1
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 240000005020 Acaciella glauca Species 0.000 description 1
- 241000254032 Acrididae Species 0.000 description 1
- 235000009434 Actinidia chinensis Nutrition 0.000 description 1
- 244000298697 Actinidia deliciosa Species 0.000 description 1
- 235000009436 Actinidia deliciosa Nutrition 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- 241000609240 Ambelania acida Species 0.000 description 1
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 241000086254 Arnica montana Species 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 240000006891 Artemisia vulgaris Species 0.000 description 1
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 description 1
- 235000005638 Austrian pine Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- MOZDKDIOPSPTBH-UHFFFAOYSA-N Benzyl parahydroxybenzoate Chemical compound C1=CC(O)=CC=C1C(=O)OCC1=CC=CC=C1 MOZDKDIOPSPTBH-UHFFFAOYSA-N 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- 241001504466 Carduelis Species 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 241000283153 Cetacea Species 0.000 description 1
- 241000422842 Chamaecyparis pisifera Species 0.000 description 1
- 240000003538 Chamaemelum nobile Species 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 244000301850 Cupressus sempervirens Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 235000018782 Dacrydium cupressinum Nutrition 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000195955 Equisetum hyemale Species 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- 241000555682 Forsythia x intermedia Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 240000001972 Gardenia jasminoides Species 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 241000208690 Hamamelis Species 0.000 description 1
- 240000000797 Hibiscus cannabinus Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 244000025221 Humulus lupulus Species 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 235000003332 Ilex aquifolium Nutrition 0.000 description 1
- 235000002296 Ilex sandwicensis Nutrition 0.000 description 1
- 235000002294 Ilex volkensiana Nutrition 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 241000218652 Larix Species 0.000 description 1
- 235000005590 Larix decidua Nutrition 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- 241000234435 Lilium Species 0.000 description 1
- 244000280244 Luffa acutangula Species 0.000 description 1
- 235000009814 Luffa aegyptiaca Nutrition 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 240000000982 Malva neglecta Species 0.000 description 1
- 235000000060 Malva neglecta Nutrition 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 244000131360 Morinda citrifolia Species 0.000 description 1
- JSCQSBGXKRTPHZ-UHFFFAOYSA-N Mucidin Natural products COC=C(C(=O)OC)C(C)=CC=CC1=CC=CC=C1 JSCQSBGXKRTPHZ-UHFFFAOYSA-N 0.000 description 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000736199 Paeonia Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 235000008565 Pinus banksiana Nutrition 0.000 description 1
- 244000019397 Pinus jeffreyi Species 0.000 description 1
- 235000013264 Pinus jeffreyi Nutrition 0.000 description 1
- 235000013697 Pinus resinosa Nutrition 0.000 description 1
- 235000008578 Pinus strobus Nutrition 0.000 description 1
- 235000008585 Pinus thunbergii Nutrition 0.000 description 1
- 235000014030 Podocarpus spicatus Nutrition 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 239000004349 Polyvinylpyrrolidone-vinyl acetate copolymer Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- NZGWDASTMWDZIW-UHFFFAOYSA-N Pulegone Natural products CC1CCC(=C(C)C)C(=O)C1 NZGWDASTMWDZIW-UHFFFAOYSA-N 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 235000019774 Rice Bran oil Nutrition 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 241001125046 Sardina pilchardus Species 0.000 description 1
- 241001647091 Saxifraga granulata Species 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- JSCQSBGXKRTPHZ-WMSPMLHYSA-N Strobilurin A Natural products COC=C(/C(=C/C=C/c1ccccc1)/C)C(=O)OC JSCQSBGXKRTPHZ-WMSPMLHYSA-N 0.000 description 1
- 239000002174 Styrene-butadiene Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- 235000004338 Syringa vulgaris Nutrition 0.000 description 1
- 244000297179 Syringa vulgaris Species 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 241000251555 Tunicata Species 0.000 description 1
- COQLPRJCUIATTQ-UHFFFAOYSA-N Uranyl acetate Chemical compound O.O.O=[U]=O.CC(O)=O.CC(O)=O COQLPRJCUIATTQ-UHFFFAOYSA-N 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 1
- 229930003756 Vitamin B7 Natural products 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- 241001135917 Vitellaria paradoxa Species 0.000 description 1
- UDRYFKCHZFVZGJ-UHFFFAOYSA-N [5-hexadecanoyloxy-4-(hexadecanoyloxymethyl)-6-methylpyridin-3-yl]methyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC1=CN=C(C)C(OC(=O)CCCCCCCCCCCCCCC)=C1COC(=O)CCCCCCCCCCCCCCC UDRYFKCHZFVZGJ-UHFFFAOYSA-N 0.000 description 1
- RKFMOTBTFHXWCM-UHFFFAOYSA-M [AlH2]O Chemical compound [AlH2]O RKFMOTBTFHXWCM-UHFFFAOYSA-M 0.000 description 1
- YFCGDEUVHLPRCZ-UHFFFAOYSA-N [dimethyl(trimethylsilyloxy)silyl]oxy-dimethyl-trimethylsilyloxysilane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C YFCGDEUVHLPRCZ-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 125000003172 aldehyde group Chemical group 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229910001413 alkali metal ion Inorganic materials 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- USMNOWBWPHYOEA-UHFFFAOYSA-N alpha-thujone Natural products CC1C(=O)CC2(C(C)C)C1C2 USMNOWBWPHYOEA-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 229940113720 aminosalicylate Drugs 0.000 description 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- 150000004982 aromatic amines Chemical class 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 235000013793 astaxanthin Nutrition 0.000 description 1
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 1
- 239000001168 astaxanthin Substances 0.000 description 1
- 229940022405 astaxanthin Drugs 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 239000010905 bagasse Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 229940095076 benzaldehyde Drugs 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229940034794 benzylparaben Drugs 0.000 description 1
- NDKBVBUGCNGSJJ-UHFFFAOYSA-M benzyltrimethylammonium hydroxide Chemical compound [OH-].C[N+](C)(C)CC1=CC=CC=C1 NDKBVBUGCNGSJJ-UHFFFAOYSA-M 0.000 description 1
- 229940066595 beta tocopherol Drugs 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- GHWVXCQZPNWFRO-UHFFFAOYSA-N butane-2,3-diamine Chemical compound CC(N)C(C)N GHWVXCQZPNWFRO-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- RZMKWKZIJJNSLQ-UHFFFAOYSA-M carpronium chloride Chemical compound [Cl-].COC(=O)CCC[N+](C)(C)C RZMKWKZIJJNSLQ-UHFFFAOYSA-M 0.000 description 1
- 229950003631 carpronium chloride Drugs 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 229940107161 cholesterol Drugs 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 1
- 229940117916 cinnamic aldehyde Drugs 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 239000008294 cold cream Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000003074 decanoyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 229910000388 diammonium phosphate Inorganic materials 0.000 description 1
- 235000019838 diammonium phosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- REKWWOFUJAJBCL-UHFFFAOYSA-L dilithium;hydrogen phosphate Chemical compound [Li+].[Li+].OP([O-])([O-])=O REKWWOFUJAJBCL-UHFFFAOYSA-L 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- WEHWNAOGRSTTBQ-UHFFFAOYSA-N dipropylamine Chemical compound CCCNCCC WEHWNAOGRSTTBQ-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 229940113120 dipropylene glycol Drugs 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- FMMOOAYVCKXGMF-MURFETPASA-N ethyl linoleate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCC FMMOOAYVCKXGMF-MURFETPASA-N 0.000 description 1
- 229940031016 ethyl linoleate Drugs 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 239000008394 flocculating agent Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 235000010382 gamma-tocopherol Nutrition 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 235000003969 glutathione Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 239000008269 hand cream Substances 0.000 description 1
- 239000011121 hardwood Substances 0.000 description 1
- 125000000268 heptanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000002391 heterocyclic compounds Chemical class 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- SFFVATKALSIZGN-UHFFFAOYSA-N hexadecan-7-ol Chemical compound CCCCCCCCCC(O)CCCCCC SFFVATKALSIZGN-UHFFFAOYSA-N 0.000 description 1
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 1
- 125000003104 hexanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 239000012433 hydrogen halide Substances 0.000 description 1
- 229910000039 hydrogen halide Inorganic materials 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- YETXGSGCWODRAA-UHFFFAOYSA-N isopropyl palmitic acid Chemical class CC(C)CCCCCCCCCCCCCCCC(O)=O YETXGSGCWODRAA-UHFFFAOYSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 150000004715 keto acids Chemical class 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- FMMOOAYVCKXGMF-UHFFFAOYSA-N linoleic acid ethyl ester Natural products CCCCCC=CCC=CCCCCCCCC(=O)OCC FMMOOAYVCKXGMF-UHFFFAOYSA-N 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 description 1
- 229910052808 lithium carbonate Inorganic materials 0.000 description 1
- 229910000032 lithium hydrogen carbonate Inorganic materials 0.000 description 1
- 229910001386 lithium phosphate Inorganic materials 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- SNKMVYBWZDHJHE-UHFFFAOYSA-M lithium;dihydrogen phosphate Chemical compound [Li+].OP(O)([O-])=O SNKMVYBWZDHJHE-UHFFFAOYSA-M 0.000 description 1
- HQRPHMAXFVUBJX-UHFFFAOYSA-M lithium;hydrogen carbonate Chemical compound [Li+].OC([O-])=O HQRPHMAXFVUBJX-UHFFFAOYSA-M 0.000 description 1
- 239000003879 lubricant additive Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229940074358 magnesium ascorbate Drugs 0.000 description 1
- 229940091250 magnesium supplement Drugs 0.000 description 1
- AIOKQVJVNPDJKA-ZZMNMWMASA-L magnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-olate Chemical compound [Mg+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] AIOKQVJVNPDJKA-ZZMNMWMASA-L 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 229930007503 menthone Natural products 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000005341 metaphosphate group Chemical group 0.000 description 1
- GDOPTJXRTPNYNR-UHFFFAOYSA-N methyl-cyclopentane Natural products CC1CCCC1 GDOPTJXRTPNYNR-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- JSCQSBGXKRTPHZ-SYKZHUKTSA-N mucidin Chemical compound CO\C=C(\C(=O)OC)/C(/C)=C\C=C\C1=CC=CC=C1 JSCQSBGXKRTPHZ-SYKZHUKTSA-N 0.000 description 1
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 1
- 125000001402 nonanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000017524 noni Nutrition 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940060184 oil ingredients Drugs 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 125000003566 oxetanyl group Chemical group 0.000 description 1
- 125000000466 oxiranyl group Chemical group 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 229930007459 p-menth-8-en-3-one Natural products 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 235000019809 paraffin wax Nutrition 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- GPCKFIWBUTWTDH-UHFFFAOYSA-N pentane-3,3-diamine Chemical compound CCC(N)(N)CC GPCKFIWBUTWTDH-UHFFFAOYSA-N 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 125000004437 phosphorous atom Chemical group 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 239000004584 polyacrylic acid Chemical class 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019448 polyvinylpyrrolidone-vinyl acetate copolymer Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 235000019828 potassium polyphosphate Nutrition 0.000 description 1
- 229940098424 potassium pyrophosphate Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- ZNZJJSYHZBXQSM-UHFFFAOYSA-N propane-2,2-diamine Chemical compound CC(C)(N)N ZNZJJSYHZBXQSM-UHFFFAOYSA-N 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 235000017985 rocky mountain lodgepole pine Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 229940058287 salicylic acid derivative anticestodals Drugs 0.000 description 1
- 150000003872 salicylic acid derivatives Chemical class 0.000 description 1
- 235000019512 sardine Nutrition 0.000 description 1
- 238000001878 scanning electron micrograph Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229940074545 sodium dihydrogen phosphate dihydrate Drugs 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 235000019830 sodium polyphosphate Nutrition 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 239000011115 styrene butadiene Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 229940073455 tetraethylammonium hydroxide Drugs 0.000 description 1
- LRGJRHZIDJQFCL-UHFFFAOYSA-M tetraethylazanium;hydroxide Chemical compound [OH-].CC[N+](CC)(CC)CC LRGJRHZIDJQFCL-UHFFFAOYSA-M 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- MVGWWCXDTHXKTR-UHFFFAOYSA-J tetralithium;phosphonato phosphate Chemical compound [Li+].[Li+].[Li+].[Li+].[O-]P([O-])(=O)OP([O-])([O-])=O MVGWWCXDTHXKTR-UHFFFAOYSA-J 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- LPSKDVINWQNWFE-UHFFFAOYSA-M tetrapropylazanium;hydroxide Chemical compound [OH-].CCC[N+](CCC)(CCC)CCC LPSKDVINWQNWFE-UHFFFAOYSA-M 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- 125000002053 thietanyl group Chemical group 0.000 description 1
- 125000001730 thiiranyl group Chemical group 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- QPQANCNBWQXGTQ-UHFFFAOYSA-N trihydroxy(trimethylsilylperoxy)silane Chemical compound C[Si](C)(C)OO[Si](O)(O)O QPQANCNBWQXGTQ-UHFFFAOYSA-N 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 125000000297 undecanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000011912 vitamin B7 Nutrition 0.000 description 1
- 239000011735 vitamin B7 Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 238000004736 wide-angle X-ray diffraction Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000009538 yokuinin Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Description
本発明は、セルロース系水溶性増粘剤、ならびにセルロース系水溶性増粘剤を含む組成物及び化粧料組成物に関する。 The present invention relates to a cellulose-based water-soluble thickener, and a composition and a cosmetic composition containing the cellulose-based water-soluble thickener.
水溶性増粘剤は、石油掘削用添加剤、コンクリート軽量化添加剤、潤滑剤用添加剤、凝集剤、水性分散剤、化粧料、衛生材料、医薬品など広範な分野で使用されている。天然系の水溶性増粘剤としては、多糖類、澱粉、寒天、セルロース及びその誘導体などが知られており、合成系の水溶性増粘剤としては、ポリアミド系化合物、ポリビニルアルコール系化合物、ポリアルキレンオキサイド系化合物、ポリアクリル酸系化合物及びこれらを組み合わせた化合物が知られている。このような水溶性増粘剤には多様化のニーズが存在し、耐熱性、耐酸性、耐アルカリ性、耐塩水性などの機能性に優れたものが求められている(特許文献1)。 Water-soluble thickeners are used in a wide range of fields such as oil drilling additives, concrete lightening additives, lubricant additives, flocculants, aqueous dispersants, cosmetics, hygiene materials, and pharmaceuticals. Known natural water-soluble thickeners include polysaccharides, starch, agar, cellulose and derivatives thereof, and synthetic water-soluble thickeners include polyamide-based compounds, polyvinyl alcohol-based compounds, Alkylene oxide compounds, polyacrylic acid compounds, and compounds combining these are known. There is a need for diversification in such water-soluble thickeners, and those having excellent functionality such as heat resistance, acid resistance, alkali resistance and salt water resistance are required (Patent Document 1).
特許文献2には、セルロース系の増粘剤として、セルロース繊維を数十nmまで微細化したセルロース粒子が開示されており、該セルロース粒子は、透明性が高く、少量の添加量で高い増粘性、分散・乳化安定能性、構造安定性が得られることが開示されている。また、特許文献3には、ゲル状組成物に、セルロース繊維表面にアルデヒド基やカルボキシル基を有する微細セルロース繊維を用いることが開示されている。 Patent Document 2 discloses cellulose particles obtained by refining cellulose fibers to several tens of nanometers as a cellulose-based thickener. The cellulose particles are highly transparent and have a high viscosity with a small amount of addition. Dispersion / emulsion stability and structure stability are disclosed. Patent Document 3 discloses that a fine cellulose fiber having an aldehyde group or a carboxyl group on the surface of the cellulose fiber is used in the gel composition.
特許文献2のセルロース系の増粘剤は、塩類等の電解質や高濃度のイオン性界面活性剤の共存下では増粘性が低下するだけでなく、セルロース粒子が沈降し、分散体としての形を取ることができないなどの難点がある。特許文献3のゲル状組成物は、塩やイオン性界面活性剤等の共存下でも高い粘性を保持することができるが、カルボキシル基を有する化合物はpH5以下の酸性化では、カルボキシル基の乖離が抑えられ、粘度が極端に低下してしまうという問題がある。このため、酸性条件が要求される処方では使用することができない。 The cellulose-based thickener of Patent Document 2 not only decreases the viscosity in the presence of electrolytes such as salts and high-concentration ionic surfactants, but also precipitates cellulose particles and forms a dispersion. There are difficulties such as being unable to take. The gel-like composition of Patent Document 3 can maintain high viscosity even in the presence of a salt, an ionic surfactant, or the like. However, when a compound having a carboxyl group is acidified at a pH of 5 or less, the carboxyl group is dissociated. There is a problem that the viscosity is extremely reduced. For this reason, it cannot be used in formulations requiring acidic conditions.
特に使用感が重要なポイントを占める化粧料のゲル化剤としては、この特徴は致命的な欠点となることがある。例えば、pH5以下の酸性条件下では、増粘剤として用いられる架橋ポリ(メタ)アクリル酸は急激な粘度低下を起こすため、十分な粘度を保持するためにはその配合量を大幅に増やさなければならず、その結果、使用感が悪くなるという問題がある。 This characteristic can be a fatal defect especially as a gelling agent for cosmetics, where the feeling of use occupies an important point. For example, under acidic conditions of pH 5 or lower, cross-linked poly (meth) acrylic acid used as a thickener causes a sharp viscosity drop, so that the blending amount must be increased significantly in order to maintain a sufficient viscosity. As a result, there is a problem that the feeling of use becomes worse.
したがって、本発明は、様々な用途に適用可能な、耐酸性を有する水溶性増粘剤を提供することを目的とする。 Therefore, an object of this invention is to provide the water-soluble thickener which has acid resistance applicable to various uses.
本発明者らは、こうした事情をかんがみ、高い増粘効果やゲル化機能を有する物質を探すべく、鋭意研究を重ねた結果、驚くべきことにリンオキソ酸基を導入した微細繊維状セルロースを増粘剤として用いたところ、耐酸性に優れることを見出した。 In light of these circumstances, the present inventors have conducted extensive research to find a substance having a high thickening effect and a gelling function. When used as an agent, it was found to be excellent in acid resistance.
すなわち、本発明は以下の発明を包含する。
(1)1000nm以下の繊維幅を有し、かつ繊維を構成するセルロースのヒドロキシ基の一部がリンオキソ酸基で置換された微細繊維状セルロースを含む増粘剤。
(2)微細繊維状セルロースの数平均繊維径が2〜150nmである、(1)に記載の増粘剤。
(3)微細繊維状セルロースが、セルロースのヒドロキシ基の一部が、下記構造式(1):
a、b、m、nは自然数であり(ただし、a=b×mである)、
α1、α2、・・・、αn及びα’のうちの少なくとも1つはO−であり、残りはR又はORであり、
Rは、各々独立して、水素原子、飽和−直鎖状炭化水素基、飽和−分岐鎖状炭化水素基、飽和−環状炭化水素基、不飽和−直鎖状炭化水素基、不飽和−分岐鎖状炭化水素基、芳香族基又はこれらの誘導基であり、
βは有機物又は無機物からなる1価以上の陽イオンである]
で表されるリンオキソ酸基で置換されたものである、(1)又は(2)に記載の増粘剤。
(4)リンオキソ酸基がリン酸基である、(1)〜(3)のいずれかに記載の増粘剤。
(5)(1)〜(4)のいずれかに記載の増粘剤と水とを含む、組成物。
(6)pH調整剤、無機塩類、界面活性剤、オイル類、保湿剤、防腐剤、有機微粒子、無機微粒子、消臭剤、香料、有機溶媒及び機能成分からなる群から選択される機能性添加剤をさらに含む、(5)に記載の組成物。
(7)pHが2〜6である、(5)又は(6)記載の組成物。
(8)化粧料組成物である、(5)〜(7)のいずれかに記載の組成物。
(9)クリーム状、ゲル状又は乳液状の剤形を有する(8)に記載の組成物。
That is, the present invention includes the following inventions.
(1) A thickening agent comprising fine fibrous cellulose having a fiber width of 1000 nm or less and having some of the hydroxy groups of cellulose constituting the fibers substituted with a phosphoroxo acid group.
(2) The thickener according to (1), wherein the number average fiber diameter of the fine fibrous cellulose is 2 to 150 nm.
(3) In the fine fibrous cellulose, a part of the hydroxy group of cellulose has the following structural formula (1):
a, b, m, and n are natural numbers (where a = b × m),
at least one of α1, α2,..., αn and α ′ is O − and the rest is R or OR;
Each R is independently a hydrogen atom, a saturated-linear hydrocarbon group, a saturated-branched hydrocarbon group, a saturated-cyclic hydrocarbon group, an unsaturated-linear hydrocarbon group, an unsaturated-branched group. A chain hydrocarbon group, an aromatic group or a derivative thereof,
β is a monovalent or higher cation made of an organic or inorganic substance]
The thickener according to (1) or (2), which is substituted with a phosphorus oxoacid group represented by:
(4) The thickener according to any one of (1) to (3), wherein the phosphorus oxoacid group is a phosphate group.
(5) A composition comprising the thickener according to any one of (1) to (4) and water.
(6) Functional addition selected from the group consisting of pH adjusters, inorganic salts, surfactants, oils, humectants, preservatives, organic fine particles, inorganic fine particles, deodorants, perfumes, organic solvents and functional components The composition according to (5), further comprising an agent.
(7) The composition according to (5) or (6), wherein the pH is 2-6.
(8) The composition according to any one of (5) to (7), which is a cosmetic composition.
(9) The composition according to (8), which has a creamy, gelled or emulsion dosage form.
本発明により、酸性条件においても粘度が低下することの少ない耐酸性を有する水溶性増粘剤が提供される。 By this invention, the water-soluble thickener which has acid resistance with little viscosity falling under acidic conditions is provided.
<微細繊維状セルロース>
本発明の増粘剤は、1000nm以下の繊維幅を有し、かつ繊維を構成するセルロースのヒドロキシ基の一部がリンオキソ酸基で置換された微細繊維状セルロースを含む。微細繊維状セルロースは、通常製紙用途で用いるパルプ繊維よりもはるかに細いセルロース繊維又は棒状粒子をさす。
<Fine fibrous cellulose>
The thickener of the present invention includes fine fibrous cellulose having a fiber width of 1000 nm or less and having some of the hydroxy groups of cellulose constituting the fibers substituted with phosphorooxy acid groups. Fine fibrous cellulose refers to cellulosic fibers or rod-like particles that are much thinner than pulp fibers typically used in papermaking applications.
リンオキソ酸基は、リン原子にヒドロキシ基とオキソ基が結合した基をさし、例えば、下記構造式(1)で表すことができる。 The phosphorus oxo acid group refers to a group in which a hydroxy group and an oxo group are bonded to a phosphorus atom, and can be represented, for example, by the following structural formula (1).
構造式(1)において、a、b、m、nは自然数である(ただし、a=b×mである。)。α1、α2、・・・、αn及びα’のうちの少なくとも1つはO−であり、残りはR又はORである。αn及びα’の全てがO−であっても構わない。nが2以上であり、α’がR又はORである場合には、各αnのうちの少なくとも1つがO−で残りがR又はORである。nが2以上であり、α’がO−である場合には、各αnは全てRであってもよいし、全てORであってもよいし、少なくとも1つがO−で残りがR又はORであってもよい。好ましくは、αn及びα’の全てがO−であり、nは1であり、βb+はアルカリ金属イオン、特にNa+であり、mは2であり、aは2である。 In the structural formula (1), a, b, m, and n are natural numbers (where a = b × m). At least one of α 1 , α 2 ,..., α n and α ′ is O − and the rest is R or OR. All of α n and α ′ may be O − . When n is 2 or more and α ′ is R or OR, at least one of each α n is O − and the rest is R or OR. When n is 2 or more and α ′ is O − , each α n may be all R or all OR, and at least one is O − and the rest is R or It may be OR. Preferably, α n and α ′ are all O − , n is 1, β b + is an alkali metal ion, in particular Na + , m is 2 and a is 2.
Rは、各々、水素原子、飽和−直鎖状炭化水素基、飽和−分岐鎖状炭化水素基、飽和−環状炭化水素基、不飽和−直鎖状炭化水素基、不飽和−分岐鎖状炭化水素基、芳香族基、及びこれらの誘導基である。 R is a hydrogen atom, a saturated-linear hydrocarbon group, a saturated-branched hydrocarbon group, a saturated-cyclic hydrocarbon group, an unsaturated-linear hydrocarbon group, an unsaturated-branched hydrocarbon group, respectively. A hydrogen group, an aromatic group, and derivatives thereof.
飽和−直鎖状炭化水素基としては、メチル基、エチル基、n−プロピル基、n−ブチル基等が挙げられる。飽和−分岐鎖状炭化水素基としては、i−プロピル基、t−ブチル基等が挙げられる。飽和−環状炭化水素基としては、シクロペンタン基、シクロヘキサン基等が挙げられる。不飽和−直鎖状炭化水素基としては、ビニル基、アリル基等が挙げられる。不飽和−分岐鎖状炭化水素基としては、i−プロペニル基、3−ブテニル基等が挙げられる。芳香族基としては、フェニル基、ナフタレン基等が挙げられる。 Examples of the saturated-linear hydrocarbon group include a methyl group, an ethyl group, an n-propyl group, and an n-butyl group. Examples of the saturated-branched hydrocarbon group include i-propyl group and t-butyl group. Examples of the saturated-cyclic hydrocarbon group include a cyclopentane group and a cyclohexane group. Examples of the unsaturated-linear hydrocarbon group include a vinyl group and an allyl group. Examples of the unsaturated-branched hydrocarbon group include i-propenyl group and 3-butenyl group. Examples of the aromatic group include a phenyl group and a naphthalene group.
前記Rにおける誘導体としては、前記各種炭化水素基の主鎖又は側鎖に対し、カルボキシ基、ヒドロキシ基、アミノ基などの官能基のうち、少なくとも1種類が付加又は置換した状態の官能基が挙げられる。 Examples of the derivative in R include a functional group in which at least one of functional groups such as a carboxy group, a hydroxy group, and an amino group is added or substituted to the main chain or side chain of the various hydrocarbon groups. It is done.
前記Rの主鎖を構成する炭素原子数は20以下であることが好ましく、10以下であることがより好ましい。Rの主鎖を構成する炭素原子数が20を超えると、Rを含むリンオキソ酸基の分子が大きくなりすぎて、繊維原料に浸透しにくくなり、微細繊維状セルロースの収率が低下するおそれがある。 The number of carbon atoms constituting the main chain of R is preferably 20 or less, and more preferably 10 or less. When the number of carbon atoms constituting the main chain of R exceeds 20, the molecule of the Roxo group containing R becomes too large, and it is difficult to penetrate into the fiber raw material, which may reduce the yield of fine fibrous cellulose. is there.
βは有機物又は無機物からなる1価以上の陽イオンである。有機物からなる1価以上の陽イオンとしては、脂肪族アンモニウム、芳香族アンモニウムが挙げられ、無機物からなる1価以上の陽イオンとしては、ナトリウム、カリウム、リチウム等のアルカリ金属のイオンや、カルシウム、マグネシウム等の2価金属の陽イオン、水素イオン等が挙げられる。これらは1種又は2種類以上を組み合わせて適用することもできる。有機物又は無機物からなる1価以上の陽イオンとしては、βを含む繊維原料を加熱した際に黄変しにくく、また工業的に利用し易いナトリウム、カリウムのイオンが好ましい。 β is a monovalent or higher cation composed of an organic substance or an inorganic substance. Examples of the monovalent or higher cation made of an organic substance include aliphatic ammonium and aromatic ammonium. Examples of the monovalent or higher cation made of an inorganic substance include ions of alkali metals such as sodium, potassium and lithium, calcium, Examples include divalent metal cations such as magnesium, hydrogen ions, and the like. These can be applied alone or in combination of two or more. As the monovalent or higher cation composed of an organic substance or an inorganic substance, sodium and potassium ions which are less likely to yellow when heated to a fiber raw material containing β and are industrially easily used are preferable.
なお、構造式(1)は、α、α’にセルロース分子鎖を含まないモノエステルであることが好ましい。α、α’にセルロース分子鎖を含む場合にはセルロース分子鎖同士が架橋しているため、微細化を阻害するおそれがある。 The structural formula (1) is preferably a monoester that does not contain a cellulose molecular chain at α and α ′. In the case where α and α ′ contain cellulose molecular chains, the cellulose molecular chains are cross-linked with each other, so that there is a possibility of inhibiting the miniaturization.
本発明において微細繊維状セルロースに導入されるリンオキソ酸基は、好ましくはリン酸基である。 In the present invention, the phosphorus oxo acid group introduced into the fine fibrous cellulose is preferably a phosphate group.
本発明の微細繊維状セルロースの繊維幅は電子顕微鏡で観察して1nm〜1000nmが好ましく、より好ましくは2nm〜500nm、さらに好ましくは4nm〜100nmである。微細繊維状セルロースの繊維幅が1nm未満であると、セルロース分子として水に溶解しているため、微細繊維状セルロースとしての物性(良好な増粘性)が発現しなくなる。一方、1000nmを超えると微細繊維状セルロースとは言えず、通常のパルプに含まれる繊維にすぎないため、ゲル状とならず十分な増粘効果を発揮しない。 The fiber width of the fine fibrous cellulose of the present invention is preferably 1 nm to 1000 nm, more preferably 2 nm to 500 nm, still more preferably 4 nm to 100 nm as observed with an electron microscope. When the fiber width of the fine fibrous cellulose is less than 1 nm, since the cellulose molecules are dissolved in water, the physical properties (good viscosity) as the fine fibrous cellulose are not expressed. On the other hand, when it exceeds 1000 nm, it cannot be said that it is a fine fibrous cellulose, and is only a fiber contained in a normal pulp, so that it does not become a gel and does not exhibit a sufficient thickening effect.
微細繊維状セルロースに透明性が求められる用途においては、繊維幅が30nmを超えると、可視光の波長の1/10に近づき、可視光の屈折及び散乱が生じ易く、透明性が低下する傾向にあるため、繊維幅は2nm〜30nmが好ましく、より好ましくは2〜20nmである。 In applications where transparency is required for fine fibrous cellulose, when the fiber width exceeds 30 nm, it approaches 1/10 of the wavelength of visible light, tends to cause refraction and scattering of visible light, and tends to decrease transparency. Therefore, the fiber width is preferably 2 nm to 30 nm, more preferably 2 to 20 nm.
微細繊維状セルロースがI型結晶構造を有していることは、グラファイトで単色化したCuKα(λ=1.5418Å)を用いた広角X線回折写真より得られる回折プロファイルにおいて、2θ=14〜17°付近と2θ=22〜23°付近の2箇所の位置に典型的なピークを有することで同定することができる。 The fact that the fine fibrous cellulose has a type I crystal structure is that 2θ = 14 to 17 in a diffraction profile obtained from a wide-angle X-ray diffraction photograph using CuKα (λ = 1.54184) monochromatized with graphite. It can be identified by having typical peaks at two positions near ° and 2θ = 22-23 °.
微細繊維状セルロースの電子顕微鏡観察による繊維幅の測定は以下のようにして行う。濃度0.05〜0.1質量%の微細繊維状セルロース含有スラリーを調製し、該スラリーを親水化処理したカーボン膜被覆グリッド上にキャストしてTEM観察用試料とする。幅広の繊維を含む場合には、ガラス上にキャストした表面のSEM像を観察してもよい。構成する繊維の幅に応じて1000倍、5000倍、10000倍、20000倍、40000倍又は50000倍の倍率で電子顕微鏡画像による観察を行う。但し、試料、観察条件や倍率は下記の条件を満たすように調整する。 Measurement of the fiber width of the fine fibrous cellulose by electron microscope observation is performed as follows. A slurry containing fine fibrous cellulose having a concentration of 0.05 to 0.1% by mass is prepared, and the slurry is cast on a carbon film-coated grid subjected to a hydrophilization treatment to obtain a sample for TEM observation. When wide fibers are included, an SEM image of the surface cast on glass may be observed. Observation by an electron microscope image is performed at a magnification of 1000 times, 5000 times, 10000 times, 20000 times, 40000 times, or 50000 times depending on the width of the constituent fibers. However, the sample, observation conditions, and magnification are adjusted to satisfy the following conditions.
(1)観察画像内の任意箇所に一本の直線Xを引き、該直線Xに対し、20本以上の繊維が交差する。
(2)同じ画像内で該直線と垂直に交差する直線Yを引き、該直線Yに対し、20本以上の繊維が交差する。
(1) One straight line X is drawn at an arbitrary location in the observation image, and 20 or more fibers intersect the straight line X.
(2) A straight line Y perpendicular to the straight line is drawn in the same image, and 20 or more fibers intersect the straight line Y.
上記条件を満足する観察画像に対し、直線X、直線Yと交錯する繊維の幅を目視で読み取る。こうして少なくとも重なっていない表面部分の画像を3組以上観察し、各々の画像に対して、直線X、直線Yと交錯する繊維の幅を読み取る。このように少なくとも20本×2×3=120本の繊維幅を読み取る。本発明における微細繊維幅はこのように読み取った繊維幅の平均値である。 The width of the fiber that intersects with the straight line X and the straight line Y is visually read from the observation image that satisfies the above conditions. In this way, at least three sets of images of the surface portion that do not overlap each other are observed, and the width of the fiber intersecting with the straight line X and the straight line Y is read for each image. Thus, at least 20 × 2 × 3 = 120 fiber widths are read. The fine fiber width in the present invention is an average value of the fiber widths thus read.
本発明の微細繊維状セルロースの繊維長及びアスペクト比は、繊維が長ければ長いほど、アスペクト比は高ければ高いほど、増粘剤として用いるために好ましい。繊維長は、TEMやSEM、AFMの画像解析より求めることができる。上記繊維長は、微細繊維の30質量%以上を占める繊維長である。 As for the fiber length and aspect ratio of the fine fibrous cellulose of the present invention, the longer the fiber and the higher the aspect ratio, the more preferable for use as a thickener. The fiber length can be obtained by image analysis of TEM, SEM, or AFM. The said fiber length is a fiber length which occupies 30 mass% or more of a fine fiber.
本発明の微細繊維状セルロースが含有する結晶部分の比率は、X線回折法によって求められる結晶化度が60%以上であるセルロース繊維であるが、結晶化度は、好ましくは65%以上、より好ましくは70%以上であると、耐熱性と低線熱膨張率発現の点でさらに優れた性能が期待できる。結晶化度については、X線回折プロファイルを測定し、そのパターンから常法により求められる(Seagalら、Textile Research Journal、29巻、786ページ、1959年)。 The ratio of the crystal part contained in the fine fibrous cellulose of the present invention is a cellulose fiber having a crystallinity obtained by X-ray diffraction of 60% or more, and the crystallinity is preferably 65% or more. When it is preferably 70% or more, further excellent performance can be expected in terms of heat resistance and low linear thermal expansion. The degree of crystallinity is obtained by measuring an X-ray diffraction profile and determining the crystallinity by a conventional method (Seagal et al., Textile Research Journal, 29, 786, 1959).
繊維原料のセルロースに、リンオキソ酸基が導入されることによって、セルロース繊維同士の電気的な反発力が強くなるものと推測される。また、スラリーとした際の分散安定性に優れる。 It is presumed that the electrical repulsive force between cellulose fibers becomes stronger by introducing a phosphorus oxo acid group into cellulose as a fiber raw material. Moreover, it is excellent in the dispersion stability at the time of making a slurry.
繊維原料のセルロースのヒドロキシ基(−OH基)におけるリンオキソ酸基の導入量は、微細繊維状セルロース1g(質量)あたり0.1〜2.0mmolが好ましく、0.2〜1.5mmolがより好ましい。リンオキソ酸基導入量が0.1mmol未満では、繊維原料の微細化が困難で、微細繊維状セルロースの安定性が劣る。リンオキソ酸基導入量が2.0mmolを超えると、微細繊維状セルロースが溶解する恐れがある。 The introduction amount of the phosphorus oxo acid group in the hydroxy group (-OH group) of the cellulose of the fiber raw material is preferably 0.1 to 2.0 mmol, more preferably 0.2 to 1.5 mmol per 1 g (mass) of fine fibrous cellulose. . If the introduction amount of the phosphorus oxo acid group is less than 0.1 mmol, it is difficult to refine the fiber raw material, and the stability of the fine fibrous cellulose is inferior. If the introduction amount of the phosphorus oxo acid group exceeds 2.0 mmol, the fine fibrous cellulose may be dissolved.
ここで、リンオキソ酸基のセルロースへの導入量は、TAPPI T237 cm−08(2008)を応用して算出した量をさす。具体的には、セルロースに導入された酸性基の導入量をより広範囲まで算出可能にするために、前記試験方法に用いる試験液のうち、炭酸水素ナトリウム(NaHCO3)/塩化ナトリウム(NaCl)=0.84g/5.85gを蒸留水で1000mlに溶解希釈した試験液を、水酸化ナトリウム1.60gを蒸留水で1000mlに溶解希釈した試験液に変更し、さらに置換基導入前後のセルロース繊維における算出値の差を実質的な置換基導入量とした以外は、TAPPI T237 cm−08(2008)に準じて算出する。 Here, the amount of phosphorus oxo acid group introduced into cellulose refers to the amount calculated by applying TAPPI T237 cm-08 (2008). Specifically, in order to make it possible to calculate the introduction amount of acidic groups introduced into cellulose over a wider range, among the test solutions used in the test method, sodium bicarbonate (NaHCO 3 ) / sodium chloride (NaCl) = The test solution in which 0.84 g / 5.85 g was dissolved and diluted in 1000 ml with distilled water was changed to a test solution in which 1.60 g of sodium hydroxide was dissolved and diluted in 1000 ml with distilled water. The calculation is performed according to TAPPI T237 cm-08 (2008) except that the difference in the calculated values is a substantial substituent introduction amount.
当該酸性基導入量算出方法は、基本的には1価の酸性基(カルボキシ基)の導入量算出方法であることから、多価の酸性基であるリンオキソ酸基の導入量の算出については、前記1価の酸性基の導入量として得られた置換基導入量を、リンオキソ酸基の酸価数で除した数値を、リンオキソ酸の基の導入量とする。 Since the method for calculating the introduction amount of the acidic group is basically a method for calculating the introduction amount of a monovalent acidic group (carboxy group), the calculation of the introduction amount of a phosphorus oxo acid group, which is a polyvalent acidic group, A value obtained by dividing the amount of substituent introduction obtained as the amount of introduction of the monovalent acidic group by the acid number of the phosphorus oxo acid group is taken as the amount of introduction of the group of phosphorus oxo acid.
<微細繊維状セルロースの製造>
上記の微細繊維状セルロースは、セルロースを含む繊維原料を、リンのオキソ酸又はその塩から選ばれる少なくとも1種の化合物(以下、「化合物A」という)により処理して、セルロースにリンオキソ酸基を導入するリンオキソ酸基導入工程(a)と、該工程(a)終了後に、リンオキソ酸基を導入したセルロース(以下、「リンオキソ酸基導入セルロース」という)を解繊処理する解繊処理工程(b)により製造できる。
<Manufacture of fine fibrous cellulose>
The fine fibrous cellulose is obtained by treating a fiber raw material containing cellulose with at least one compound selected from oxo acid of phosphorus or a salt thereof (hereinafter referred to as “compound A”), and thereby adding a phosphorus oxo acid group to the cellulose. Phosphooxo acid group introduction step (a) to be introduced and, after the completion of the step (a), a fibrillation treatment step (b) for defibration treatment of the cellulose into which the phosphorus oxo acid group has been introduced (hereinafter referred to as “phosphorous acid group introduced cellulose”) ).
[リンオキソ酸基導入工程(a)]
繊維原料を化合物Aにより処理する方法としては、乾燥状態又は湿潤状態の繊維原料に化合物Aの粉末や水溶液を混合する方法、繊維原料のスラリーに化合物Aの粉末や水溶液を添加する方法等が挙げられる。これらのうち、反応の均一性が高いことから、乾燥状態の繊維原料(パルプ)に化合物Aの水溶液を添加する方法、又は湿潤状態の繊維原料(パルプ)に化合物Aの粉末や水溶液を添加する方法が好ましい。
[Phosphooxo group introduction step (a)]
Examples of the method of treating the fiber raw material with the compound A include a method of mixing the powder or aqueous solution of the compound A with the dry or wet fiber raw material, a method of adding the powder or aqueous solution of the compound A to the fiber raw material slurry, and the like. It is done. Among these, since the uniformity of the reaction is high, a method of adding an aqueous solution of Compound A to a dry fiber raw material (pulp) or a powder or aqueous solution of Compound A to a wet fiber raw material (pulp) The method is preferred.
セルロースを含む繊維原料としては、製紙用パルプ、コットンリンターやコットンリントなどの綿系パルプ、麻、麦わら、バガスなどの非木材系パルプ、ホヤや海草などから単離されるセルロースなどが挙げられる。これらの中でも、入手のしやすさという点で、製紙用パルプが好ましい。製紙用パルプとしては、広葉樹クラフトパルプ(晒クラフトパルプ(LBKP)、未晒クラフトパルプ(LUKP)、酸素漂白クラフトパルプ(LOKP)など)、針葉樹クラフトパルプ(晒クラフトパルプ(NBKP)、未晒クラフトパルプ(NUKP)、酸素漂白クラフトパルプ(NOKP)など)、サルファイトパルプ(SP)、ソーダパルプ(AP)等の化学パルプ、セミケミカルパルプ(SCP)、ケミグラウンドウッドパルプ(CGP)等の半化学パルプ、砕木パルプ(GP)、サーモメカニカルパルプ(TMP、BCTMP)等の機械パルプ、楮、三椏、麻、ケナフ等を原料とする非木材パルプ、古紙を原料とする脱墨パルプが挙げられる。繊維原料は1種を単独で用いてもよいし、2種以上混合して用いてもよい。 Examples of the fiber raw material containing cellulose include paper pulp, cotton pulp such as cotton linter and cotton lint, non-wood pulp such as hemp, straw and bagasse, cellulose isolated from sea squirts and seaweeds, and the like. Among these, paper pulp is preferable in terms of availability. Paper pulp includes hardwood kraft pulp (bleached kraft pulp (LBKP), unbleached kraft pulp (LUKP), oxygen bleached kraft pulp (LOKP), etc.), softwood kraft pulp (bleached kraft pulp (NBKP), unbleached kraft pulp) (NUKKP, oxygen bleached kraft pulp (NOKP), etc.), sulfite pulp (SP), chemical pulp such as soda pulp (AP), semi-chemical pulp (SCP), semi-chemical pulp such as chemiground wood pulp (CGP) In addition, mechanical pulp such as groundwood pulp (GP) and thermomechanical pulp (TMP, BCTMP), non-wood pulp using raw material such as cocoon, sardine, hemp, kenaf and the like, and deinked pulp using raw paper as a raw material. A fiber raw material may be used individually by 1 type, and may be used in mixture of 2 or more types.
上記繊維原料の中でも、入手のしやすさという点で、木材パルプ、脱墨パルプが好ましい。さらに、木材パルプの中でも、化学パルプはセルロース比率が大きいため、微細繊維状セルロースの収率が高く、また、パルプ中のセルロースの分解が小さく、軸比の大きい長繊維の微細繊維状セルロースが得られる点で特に好ましい。化学パルプの中でもクラフトパルプ、サルファイトパルプが最も好ましく選択される。 Among the fiber raw materials, wood pulp and deinked pulp are preferable in terms of easy availability. Furthermore, among wood pulps, chemical pulp has a high cellulose ratio, so the yield of fine fibrous cellulose is high, and the cellulose in pulp is small and long fiber fine fibrous cellulose with a large axial ratio is obtained. Are particularly preferable. Among chemical pulps, kraft pulp and sulfite pulp are most preferably selected.
製紙用パルプは、ダブルディスクリファイナー、シングルディスクリファイナー、ビーターなどで叩解してもよいが、叩解があまり進んでいないパルプ(カナダ標準濾水度(CSF)が好ましくは400ml以上、より好ましくは500ml以上のパルプ)を用いることが好ましい。叩解があまり進んでいないパルプを用いると、後述する解繊処理工程で得られる微細繊維状セルロース同士の絡み合いを少なくでき、微細繊維状セルロースの安定性が向上する。また、後述するアルカリ処理前後にパルプを水や有機溶媒で洗浄する際の脱水洗浄性が向上する。 Pulp for papermaking may be beaten with a double disc refiner, a single disc refiner, a beater, etc., but pulp that is not sufficiently beaten (Canadian Standard Freeness (CSF) is preferably 400 ml or more, more preferably 500 ml or more. Pulp). When a pulp that is not so much beaten is used, the entanglement between the fine fibrous celluloses obtained in the defibrating process described later can be reduced, and the stability of the fine fibrous cellulose is improved. Moreover, the dehydration detergency at the time of wash | cleaning a pulp with water or an organic solvent before and behind the alkali treatment mentioned later improves.
本発明で使用する化合物Aとしては、リン酸及びポリリン酸などのリン酸基を有する化合物、亜リン酸、ホスホン酸、ポリホスホン酸又はこれらの塩若しくはエステルが挙げられる。 Examples of the compound A used in the present invention include compounds having a phosphoric acid group such as phosphoric acid and polyphosphoric acid, phosphorous acid, phosphonic acid, polyphosphonic acid, and salts or esters thereof.
これらの中でも、低コストであり、扱いやすく、また、セルロースのヒドロキシ基にリン酸基を導入して解繊効率をより向上できることから、リン酸基を有する化合物が好ましい。リン酸基を有する化合物としては、リン酸、リン酸のリチウム塩であるリン酸二水素リチウム、リン酸水素二リチウム、リン酸三リチウム、ピロリン酸リチウム、ポリリン酸リチウム、更にリン酸のナトリウム塩であるリン酸二水素ナトリウム、リン酸水素二ナトリウム、リン酸三ナトリウム、ピロリン酸ナトリウム、ポリリン酸ナトリウム、更にリン酸のカリウム塩であるリン酸二水素カリウム、リン酸水素二カリウム、リン酸三カリウム、ピロリン酸カリウム、ポリリン酸カリウムなどが挙げられる。 Among these, a compound having a phosphoric acid group is preferable because it is low-cost, easy to handle, and can further improve the fibrillation efficiency by introducing a phosphoric acid group into the hydroxy group of cellulose. Examples of the compound having a phosphoric acid group include phosphoric acid, lithium dihydrogen phosphate which is a lithium salt of phosphoric acid, dilithium hydrogen phosphate, trilithium phosphate, lithium pyrophosphate, lithium polyphosphate, and sodium salt of phosphoric acid. Sodium dihydrogen phosphate, disodium hydrogen phosphate, trisodium phosphate, sodium pyrophosphate, sodium polyphosphate, and the potassium salt of phosphoric acid, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, triphosphate Examples include potassium, potassium pyrophosphate, and potassium polyphosphate.
これらのうち、リン酸基導入の効率が高く、下記解繊工程で解繊効率がより向上しやすく、低コストであり、かつ工業的に適用しやすい観点から、リン酸、リン酸のナトリウム塩、リン酸のカリウム塩が好ましく、リン酸二水素ナトリウム、リン酸水素二ナトリウムがより好ましい。 Among these, phosphoric acid, sodium salt of phosphoric acid, from the viewpoint of high efficiency of introducing phosphate groups, easy improvement of the defibrating efficiency in the following defibrating process, low cost, and industrial applicability A potassium salt of phosphoric acid is preferable, and sodium dihydrogen phosphate and disodium hydrogen phosphate are more preferable.
また、反応の均一性が高まり、且つリンオキソ酸基導入の効率が高くなることから化合物Aは水溶液として用いることが好ましい。化合物Aの水溶液のpHは、リンオキソ酸基導入の効率が高くなることから7以下であることが好ましいが、パルプ繊維の加水分解を抑える観点からpH3〜7が好ましい。 Further, the compound A is preferably used as an aqueous solution because the uniformity of the reaction is increased and the efficiency of introduction of the phosphorus oxo acid group is increased. The pH of the aqueous solution of Compound A is preferably 7 or less because the efficiency of introduction of the phosphorus oxoacid group is high, but is preferably 3 to 7 from the viewpoint of suppressing hydrolysis of pulp fibers.
繊維原料に対する化合物Aの質量割合は、繊維原料100質量部に対して化合物Aが、リン元素量として0.2〜500質量部が好ましく、1〜400質量部がより好ましく、2〜200質量部が最も好ましい。化合物Aの割合が前記下限値以上であれば、微細繊維状セルロースの収率をより向上させることができる。しかし、前記上限値を超えても、収率向上の効果は頭打ちとなり、無駄に化合物Aを使用するだけである。 The mass ratio of the compound A to the fiber raw material is preferably 0.2 to 500 parts by mass, more preferably 1 to 400 parts by mass, and 2 to 200 parts by mass with respect to 100 parts by mass of the fiber raw material. Is most preferred. If the ratio of the compound A is more than the said lower limit, the yield of fine fibrous cellulose can be improved more. However, even if the upper limit is exceeded, the effect of improving the yield reaches its peak and only the compound A is used in vain.
工程(a)においては加熱処理を施すことが好ましい。加熱処理温度は、セルロースの熱分解温度の点から、250℃以下であることが好ましい。また、セルロースの加水分解を抑える観点から、加熱処理温度は100〜170℃であることが好ましい。さらに、加熱処理の際に化合物Aを添加した繊維原料スラリーに水が含まれている間の加熱については、好ましくは130℃以下、より好ましくは110℃以下で加熱して充分にスラリーの水分を除去乾燥した後、100〜170℃で加熱処理することが好ましい。また、スラリー中の水分を除く際には減圧乾燥機を用いてもよい。 In the step (a), heat treatment is preferably performed. It is preferable that the heat processing temperature is 250 degrees C or less from the point of the thermal decomposition temperature of a cellulose. Moreover, it is preferable that the heat processing temperature is 100-170 degreeC from a viewpoint of suppressing hydrolysis of a cellulose. Furthermore, for heating while the fiber raw material slurry to which Compound A is added during the heat treatment contains water, it is preferably 130 ° C. or lower, more preferably 110 ° C. or lower to sufficiently remove the water in the slurry. After removing and drying, heat treatment is preferably performed at 100 to 170 ° C. Moreover, you may use a vacuum dryer when removing the water | moisture content in a slurry.
[解繊処理工程(b)]
解繊処理工程(b)では、通常、解繊処理装置を用いて、リンオキソ酸基導入セルロースを解繊処理して、微細繊維状セルロース含有スラリーを得る。解繊処理の際には、リンオキソ酸基導入セルロースを水と有機溶媒を単独又は組み合わせて希釈してスラリー状にすることが好ましい。希釈後のリンオキソ酸基導入セルロースの固形分濃度は0.1〜20質量%であることが好ましく、0.5〜10質量%であることがより好ましい。希釈後のリンオキソ酸基導入セルロースの固形分濃度が前記下限値以上であれば、解繊処理の効率が向上し、前記上限値以下であれば、解繊処理装置内での閉塞を防止できる。
[Defibration processing step (b)]
In the defibrating treatment step (b), a cellulose fiber-containing slurry is usually obtained by defibrating the phosphooxo acid group-introduced cellulose using a defibrating device. In the defibrating treatment, it is preferable to dilute the phosphorus oxo acid group-introduced cellulose into a slurry by diluting water and an organic solvent alone or in combination. The solid content concentration of the diluted phosphorus oxo acid group-introduced cellulose is preferably 0.1 to 20% by mass, and more preferably 0.5 to 10% by mass. If the solid content concentration of the diluted phosphooxo acid group-introduced cellulose is equal to or higher than the lower limit, the efficiency of the fibrillation treatment is improved, and if it is equal to or lower than the upper limit, blockage in the defibrating apparatus can be prevented.
得られたスラリーを乾燥することで、乾燥状態の微細繊維状セルロースを得ることもできる。乾燥法としては、当技術分野で公知の方法を使用でき、例えば、スプレードライ法、凍結乾燥法、ドラムドライヤーによる乾燥法、噴霧乾燥法等が用いられる。増粘剤としては、微細繊維状セルロースのスラリーをそのまま用いてもよいし、スラリーを乾燥したものを用いてもよい。 By drying the obtained slurry, it is also possible to obtain a fine fibrous cellulose in a dry state. As a drying method, a method known in the art can be used. For example, a spray drying method, a freeze drying method, a drying method using a drum dryer, a spray drying method, or the like is used. As the thickener, a fine fibrous cellulose slurry may be used as it is, or a slurry obtained by drying the slurry may be used.
[その他の処理]
上記微細繊維状セルロースの製造方法において、工程(a)と工程(b)の間にアルカリ処理工程を有すると、微細繊維状セルロースの収率が向上するため、好ましい。また、該アルカリ処理によって、セルロースに導入されたリンオキソ酸基に陽イオンを供給して、容易に塩にすることができる。
[Other processing]
In the manufacturing method of the said fine fibrous cellulose, since it has the alkali treatment process between a process (a) and a process (b), since the yield of a fine fibrous cellulose improves, it is preferable. In addition, by the alkali treatment, a cation can be supplied to the phosphorus oxo acid group introduced into the cellulose to easily form a salt.
アルカリ処理の方法としては、特に限定されないが、例えば、アルカリ溶液中に、リンオキソ酸基導入セルロースを浸漬する方法が挙げられる。アルカリ溶液に含まれるアルカリ化合物は、無機アルカリ化合物であってもよいし、有機アルカリ化合物であってもよい。無機アルカリ化合物としては、アルカリ金属の水酸化物又はアルカリ土類金属の水酸化物、アルカリ金属の炭酸塩又はアルカリ土類金属の炭酸塩、アルカリ金属のリン酸塩又はアルカリ土類金属のリン酸塩が挙げられる。アルカリ金属の水酸化物としては、水酸化リチウム、水酸化ナトリウム、水酸化カリウムが挙げられ、アルカリ土類金属の水酸化物としては、水酸化カルシウムが挙げられる。 The method for the alkali treatment is not particularly limited, and examples thereof include a method of immersing the phosphorooxy acid group-introduced cellulose in an alkali solution. The alkali compound contained in the alkali solution may be an inorganic alkali compound or an organic alkali compound. Inorganic alkali compounds include alkali metal hydroxides or alkaline earth metal hydroxides, alkali metal carbonates or alkaline earth metal carbonates, alkali metal phosphates or alkaline earth metal phosphates Salt. Examples of the alkali metal hydroxide include lithium hydroxide, sodium hydroxide, and potassium hydroxide, and examples of the alkaline earth metal hydroxide include calcium hydroxide.
アルカリ金属の炭酸塩としては炭酸リチウム、炭酸水素リチウム、炭酸カリウム、炭酸水素カリウム、炭酸ナトリウム、炭酸水素ナトリウムが挙げられる。アルカリ土類金属の炭酸塩としては炭酸カルシウムなどが挙げられる。 Examples of the alkali metal carbonate include lithium carbonate, lithium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, sodium carbonate, and sodium hydrogen carbonate. Examples of the alkaline earth metal carbonate include calcium carbonate.
アルカリ金属のリン酸塩としてはリン酸リチウム、リン酸カリウム、リン酸3ナトリウム、リン酸水素2ナトリウムなどが挙げられる。アルカリ土類金属のリン酸塩としてはリン酸カルシウム、リン酸水素カルシウムなどが挙げられる。 Examples of the alkali metal phosphate include lithium phosphate, potassium phosphate, trisodium phosphate, and disodium hydrogen phosphate. Examples of alkaline earth metal phosphates include calcium phosphate and calcium hydrogen phosphate.
有機アルカリ化合物としては、アンモニア、脂肪族アミン、芳香族アミン、脂肪族アンモニウム、芳香族アンモニウム、複素環式化合物及びその水酸化物、炭酸塩、リン酸塩等が挙げられる。例えば、アンモニア、ヒドラジン、メチルアミン、エチルアミン、ジエチルアミン、トリエチルアミン、プロピルアミン、ジプロピルアミン、ブチルアミン、ジアミノエタン、ジアミノプロパン、ジアミノブタン、ジアミノペンタン、ジアミノヘキサン、シクロヘキシルアミン、アニリン、テトラメチルアンモニウムヒドロキシド、テトラエチルアンモニウムヒドロキシド、テトラプロピルアンモニウムヒドロキシド、テトラブチルアンモニウムヒドロキシド、ベンジルトリメチルアンモニウムヒドロキシド、ピリジン、N,N−ジメチル−4−アミノピリジン、炭酸アンモニウム、炭酸水素アンモニウム、リン酸水素2アンモニウム等が挙げられる。 Examples of the organic alkali compounds include ammonia, aliphatic amines, aromatic amines, aliphatic ammoniums, aromatic ammoniums, heterocyclic compounds and their hydroxides, carbonates, and phosphates. For example, ammonia, hydrazine, methylamine, ethylamine, diethylamine, triethylamine, propylamine, dipropylamine, butylamine, diaminoethane, diaminopropane, diaminobutane, diaminopentane, diaminohexane, cyclohexylamine, aniline, tetramethylammonium hydroxide, Tetraethylammonium hydroxide, tetrapropylammonium hydroxide, tetrabutylammonium hydroxide, benzyltrimethylammonium hydroxide, pyridine, N, N-dimethyl-4-aminopyridine, ammonium carbonate, ammonium hydrogen carbonate, diammonium hydrogen phosphate, etc. Can be mentioned.
アルカリ溶液における溶媒としては水又は有機溶媒のいずれであってもよいが、極性溶媒(水、アルコール等の極性有機溶媒)が好ましく、少なくとも水を含む水系溶媒がより好ましい。また、アルカリ溶液のうちでは、汎用性が高いことから、水酸化ナトリウム水溶液、水酸化カリウム水溶液が特に好ましい。 The solvent in the alkaline solution may be either water or an organic solvent, but a polar solvent (polar organic solvent such as water or alcohol) is preferred, and an aqueous solvent containing at least water is more preferred. Of the alkaline solutions, sodium hydroxide aqueous solution and potassium hydroxide aqueous solution are particularly preferred because of their high versatility.
リンオキソ酸基導入セルロースを浸漬させたアルカリ溶液の25℃におけるpHは9以上であることが好ましく、10以上であることがより好ましく、11〜14であることがさらに好ましい。アルカリ溶液のpHが前記下限値以上であれば、微細繊維状セルロースの収率がより高くなる。しかし、pHが14を超えると、アルカリ溶液の取り扱い性が低下する。 The pH at 25 ° C. of the alkaline solution in which the phosphorus oxo acid group-introduced cellulose is immersed is preferably 9 or more, more preferably 10 or more, and even more preferably 11-14. If the pH of the alkaline solution is at least the lower limit, the yield of fine fibrous cellulose will be higher. However, when pH exceeds 14, the handleability of an alkaline solution will fall.
セルロースには、さらなる化学修飾処理を施してもよい。ここで、化学修飾とは、セルロース中のヒドロキシ基に化学修飾剤を反応させて付加させることである。化学修飾処理は、微細繊維状セルロースの製造のどの時点で行ってもよく、繊維原料に施してもよいし、リンオキソ酸基導入セルロースに施してもよい。また、化学修飾処理を、リンオキソ酸基導入工程と同時に行ってもよい。 Cellulose may be further chemically modified. Here, the chemical modification is to add a chemical modifying agent by reacting with a hydroxy group in cellulose. The chemical modification treatment may be performed at any point in the production of the fine fibrous cellulose, may be performed on the fiber raw material, or may be performed on the phosphorus oxo acid group-introduced cellulose. Further, the chemical modification treatment may be performed simultaneously with the phosphorus oxo acid group introduction step.
化学修飾によってセルロースに導入させる官能基としては、アセチル基、アクリロイル基、メタクリロイル基、プロピオニル基、プロピオロイル基、ブチリル基、2−ブチリル基、ペンタノイル基、ヘキサノイル基、ヘプタノイル基、オクタノイル基、ノナノイル基、デカノイル基、ウンデカノイル基、ドデカノイル基、ミリストイル基、パルミトイル基、ステアロイル基、ピバロイル基、ベンゾイル基、ナフトイル基、ニコチノイル基、イソニコチノイル基、フロイル基、シンナモイル基等のアシル基、2−メタクリロイルオキシエチルイソシアノイル基等のイソシアネート基、メチル基、エチル基、プロピル基、2−プロピル基、ブチル基、2−ブチル基、tert−ブチル基、ペンチル基、ヘキシル基、ヘプチル基、オクチル基、ノニル基、デシル基、ウンデシル基、ドデシル基、ミリスチル基、パルミチル基、ステアリル基等のアルキル基、オキシラン基、オキセタン基、チイラン基、チエタン基等が挙げられる。これらの中では特にアセチル基、アクリロイル基、メタクリロイル基、ベンゾイル基、ナフトイル基等の炭素数2〜12のアシル基、メチル基、エチル基、プロピル基等の炭素数1〜12のアルキル基が好ましい。 As functional groups to be introduced into cellulose by chemical modification, acetyl group, acryloyl group, methacryloyl group, propionyl group, propioroyl group, butyryl group, 2-butyryl group, pentanoyl group, hexanoyl group, heptanoyl group, octanoyl group, nonanoyl group, Decanoyl group, undecanoyl group, dodecanoyl group, myristoyl group, palmitoyl group, stearoyl group, pivaloyl group, benzoyl group, naphthoyl group, nicotinoyl group, isonicotinoyl group, furoyl group, acyl group such as cinnamoyl group, 2-methacryloyloxyethylisocyanoyl Isocyanate group such as a group, methyl group, ethyl group, propyl group, 2-propyl group, butyl group, 2-butyl group, tert-butyl group, pentyl group, hexyl group, heptyl group, octyl group, noni Group, decyl group, undecyl group, dodecyl group, myristyl group, palmityl group, an alkyl group such as a stearyl group, an oxirane group, an oxetane group, a thiirane group, or the like thietane group. Among these, an acyl group having 2 to 12 carbon atoms such as an acetyl group, an acryloyl group, a methacryloyl group, a benzoyl group and a naphthoyl group, and an alkyl group having 1 to 12 carbon atoms such as a methyl group, an ethyl group and a propyl group are preferable. .
<組成物>
本発明はまた、1000nm以下の繊維幅を有し、かつ繊維を構成するセルロースのヒドロキシ基の一部がリンオキソ酸基で置換された微細繊維状セルロースと水とを含む組成物に関する。本発明の組成物は、さらに、機能性添加剤を含んでいてもよい。機能性添加剤としては、例えば、pH調整剤、無機塩類、有機塩類、界面活性剤、オイル類、保湿剤、防腐剤、有機微粒子、無機微粒子、消臭剤、香料、有機溶媒、機能成分等が挙げられる。これらは単独で用いてもよく、二種以上併せて用いてもよい。
<Composition>
The present invention also relates to a composition comprising fine fibrous cellulose having a fiber width of 1000 nm or less and having a portion of the hydroxy groups of cellulose constituting the fibers substituted with a phosphoroxo acid group and water. The composition of the present invention may further contain a functional additive. Examples of functional additives include pH adjusters, inorganic salts, organic salts, surfactants, oils, moisturizers, preservatives, organic fine particles, inorganic fine particles, deodorants, fragrances, organic solvents, functional ingredients, and the like. Is mentioned. These may be used alone or in combination of two or more.
pH調整剤は、食品や化粧品のpHをコントロールするものであり、例えば、クエン酸、リンゴ酸、酒石酸、乳酸、アジピン酸、グルタミン酸、アスパラギン酸、マレイン酸等の有機酸が挙げられる。 The pH adjuster controls the pH of foods and cosmetics, and examples thereof include organic acids such as citric acid, malic acid, tartaric acid, lactic acid, adipic acid, glutamic acid, aspartic acid, and maleic acid.
無機塩類としては、水に溶解・分散できるものが好ましく、例えば、アルカリ金属、アルカリ土類金属、遷移金属と、ハロゲン化水素、硫酸、炭酸等からなる塩類が挙げられ、具体的には、NaCl、KCl、CaCl2、MgCl2、(NH4)2SO4、Na2CO3等が挙げられる。これらは単独で用いてもよく、二種以上併せて用いてもよい。 As the inorganic salts, those that can be dissolved and dispersed in water are preferable, and examples thereof include salts made of alkali metal, alkaline earth metal, transition metal, hydrogen halide, sulfuric acid, carbonic acid, and the like. Specifically, NaCl is used. , KCl, CaCl 2 , MgCl 2 , (NH 4 ) 2 SO 4 , Na 2 CO 3 and the like. These may be used alone or in combination of two or more.
有機塩類としては、アルカリ金属、アルカリ土類金属等の水酸化物や、有機アミンと分子中に存在するカルボキシル基、リン酸基、スルホン酸基等を中和することにより実質的に水溶性、水分散性を示す物質であれば特に限定することなく用いられる。これらは単独で用いてもよく、二種以上併せて用いてもよい。 Organic salts are substantially water-soluble by neutralizing hydroxides such as alkali metals and alkaline earth metals, organic amines and carboxyl groups, phosphoric acid groups, sulfonic acid groups, etc. present in the molecule. Any substance that exhibits water dispersibility can be used without particular limitation. These may be used alone or in combination of two or more.
界面活性剤としては、例えば、プロピレングリコール脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステルソルビタン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、ポリエチレングリコール脂肪酸エステル、ポリオキシエチレンひまし油、ポリオキシエチレン硬化ひまし油、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンフィトステロール、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレンラノリン、ポリオキシエチレンラノリンアルコール、ポリオキシエチレンミツロウ誘導体、ポリオキシエチレンアルキルアミン、ポリオキシエチレン脂肪酸アミド、ポリオキシエチレンアルキルフェニルホルムアルデヒド縮合体、ポリオキシエチレンアルキルエーテルリン酸(塩)等の非イオン界面活性剤;アルキル硫酸エステル塩、ポリオキシエチレンアルキル硫酸エステル塩、アルキルベンゼンスルホン酸塩、α−オレフィンスルホン酸塩等のアニオン界面活性剤;塩化アルキルトリメチルアンモニウム、塩化ジアルキルジメチルアンモニウム、塩化ベンザルコニウム等のカチオン界面活性剤;レシチン、ラノリン、コレステロール、サポニン等の界面活性能を有する天然物;スルホコハク酸エステル類やエチレンオキシド−プロピレンオキシドブロック共重合体等のような低刺激性界面活性剤;ラウリルジメチルアミノ酢酸ベタイン等の両性界面活性剤等が挙げられる。これらは単独で用いてもよく、二種以上併せて用いてもよい。 Examples of the surfactant include propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyglycerin fatty acid ester sorbitan fatty acid ester, polyoxyethylene sorbite fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene Hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene phytosterol, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxyethylene beeswax derivative, polyoxyethylene Alkylamine, polyoxyethylene fatty acid amide, polyoxye Nonionic surfactants such as lenalkylphenyl formaldehyde condensates and polyoxyethylene alkyl ether phosphates (salts); alkyl sulfate ester salts, polyoxyethylene alkyl sulfate ester salts, alkylbenzene sulfonates, α-olefin sulfonates, etc. Anionic surfactants; cationic surfactants such as alkyltrimethylammonium chloride, dialkyldimethylammonium chloride and benzalkonium chloride; natural products having surface-active ability such as lecithin, lanolin, cholesterol and saponin; sulfosuccinic acid esters and ethylene oxide -Hypoallergenic surfactants such as propylene oxide block copolymers; amphoteric surfactants such as lauryldimethylaminoacetic acid betaine. These may be used alone or in combination of two or more.
オイル類としては、例えば、ホホバ油、マカデミアナッツ油、アボガド油、月見草油、ミンク油、ナタネ油、ヒマシ油、ヒマワリ油、トウモロコシ油、カカオ油、ヤシ油、コメヌカ油、オリーブ油、アーモンド油、ごま油、サフラワー油、大豆油、椿油、パーシック油、綿花油、モクロウ、パーム油、パーム核油、卵黄油、ラノリン、スクワレン等の天然動植物油脂類;合成トリグリセライド、スクワラン、流動パラフィン、ワセリン、セレシン、マイクロクリスタリンワックス、イソパラフィン等の炭化水素類;カルナバウロウ、パラフィンワックス、鯨ロウ、ミツロウ、キヤンデリラワックス、ラノリン等のワックス類;セタノール、ステアリルアルコール、ラウリルアルコール、セトステアリルアルコール、オレイルアルコール、ベヘニルアルコール、ラノリンアルコール、水添ラノリンアルコール、ヘキシルデカノール、オクチルドデカノール等の高級アルコール類、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘニン酸、イソステアリン酸、オレイン酸、リノレン酸、リノール酸、オキシステアリン酸、ウンデシレン酸、ラノリン脂肪酸、硬質ラノリン脂肪酸、軟質ラノリン脂肪酸等の高級脂肪酸類;コレステリル−オクチルドデシル−ベヘニル等のコレステロールおよびその誘導体;イソプロピルミリスチン酸、イソプロピルパルミチン酸、イソプロピルステアリン酸、2−エチルヘキサン酸グリセロール、ブチルステアリン酸等のエステル類;ジエチレングリコールモノプロピルエーテル、ポリオキシエチレンポリオキシプロピレンペンタエリトリトールエーテル、ポリオキシプロピレンブチルエーテル、リノール酸エチル等の極性オイル等が挙げられる。例えば、アミノ変性シリコーン、エポキシ変性シリコーン、カルボキシル変性シリコーン、カルビノール変性シリコーン、メタクリル変性シリコーン、メルカプト変性シリコーン、フェノール変性シリコーン、片末端反応性シリコーン、異種官能基変性シリコーン、ポリエーテル変性シリコーン、メチルスチリル変性シリコーン、アルキル変性シリコーン、高級脂肪酸変性シリコーン、親水性特殊変性シリコーン、高級アルコキシ変性シリコーン、高級脂肪酸含有シリコーン、フッ素変性シリコーン等が挙げられ、より具体的には、シリコーン樹脂、メチルフェニルポリシロキサン、メチルポリシロキサン、オクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサンシロキサン、メチルシクロポリシロキサン、オクタンメチルトリシロキサン、デカメチルテトラシロキサン、ポリオキシエチレン−メチルポリシロキサン共重合体、ポリオキシプロピレン−メチルポリシロキサン共重合体、ポリ(オキシエチレン−オキシプロピレン)メチルポリシロキサン共重合体、メチルハイドロゲンポリシロキサン、テトラヒドロテトラメチルシクロテトラシロキサン、ステアロキシメチルポリシロキサン、セトキシメチルポリシロキサン、メチルポリシロキサンエマルジョン、高重合メチルポリシロキサン、トリメチルシロキシケイ酸、架橋型メチルポリシロキサン、架橋型メチルフェニルポリシロキサン、架橋型メチルフェニルポリシロキサン、架橋型メチルフェニルポリシロキサン等の各種誘導体を含むシリコーン類等が挙げられる。これらは単独で用いてもよく、二種以上併せて用いてもよい。 Examples of oils include jojoba oil, macadamia nut oil, avocado oil, evening primrose oil, mink oil, rapeseed oil, castor oil, sunflower oil, corn oil, cacao oil, coconut oil, rice bran oil, olive oil, almond oil, sesame oil, Natural animal and vegetable fats and oils such as safflower oil, soybean oil, cocoon oil, persic oil, cotton oil, molasses, palm oil, palm kernel oil, egg yolk oil, lanolin, squalene; synthetic triglyceride, squalane, liquid paraffin, petrolatum, ceresin, micro Hydrocarbons such as crystallin wax, isoparaffin, etc .; waxes such as carnauba wax, paraffin wax, whale wax, beeswax, chiyandelilla wax, lanolin; cetanol, stearyl alcohol, lauryl alcohol, cetostearyl alcohol, oleyl alcohol, behe Alcohols, lanolin alcohols, hydrogenated lanolin alcohols, higher alcohols such as hexyl decanol, octyldodecanol, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid, oleic acid, linolenic acid, linoleic acid, oxy Higher fatty acids such as stearic acid, undecylenic acid, lanolin fatty acid, hard lanolin fatty acid, soft lanolin fatty acid; cholesterol and its derivatives such as cholesteryl-octyldodecyl-behenyl; isopropyl myristic acid, isopropyl palmitic acid, isopropyl stearic acid, 2-ethyl Esters such as glycerol hexanoate and butyl stearate; diethylene glycol monopropyl ether, polyoxyethylene polyoxypropylene pentaerythritol Over ether, polyoxypropylene butyl ether, and polar oil such as ethyl linoleate. For example, amino-modified silicone, epoxy-modified silicone, carboxyl-modified silicone, carbinol-modified silicone, methacryl-modified silicone, mercapto-modified silicone, phenol-modified silicone, one-end reactive silicone, heterofunctional functional silicone, polyether-modified silicone, methylstyryl Modified silicone, alkyl-modified silicone, higher fatty acid-modified silicone, hydrophilic specially modified silicone, higher alkoxy-modified silicone, higher fatty acid-containing silicone, fluorine-modified silicone, and the like. More specifically, silicone resin, methylphenyl polysiloxane, Methylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, methylcyclo Resiloxane, octanemethyltrisiloxane, decamethyltetrasiloxane, polyoxyethylene-methylpolysiloxane copolymer, polyoxypropylene-methylpolysiloxane copolymer, poly (oxyethylene-oxypropylene) methylpolysiloxane copolymer, Methyl hydrogen polysiloxane, tetrahydrotetramethylcyclotetrasiloxane, stearoxymethyl polysiloxane, cetoxymethyl polysiloxane, methyl polysiloxane emulsion, highly polymerized methyl polysiloxane, trimethylsiloxysilicic acid, crosslinked methylpolysiloxane, crosslinked methylphenyl Examples thereof include silicones containing various derivatives such as polysiloxane, cross-linked methylphenyl polysiloxane, and cross-linked methylphenyl polysiloxane. These may be used alone or in combination of two or more.
保湿剤としては、例えば、ヒアルロン酸、スクワラン、グリセリン、1,3−ブチレングリコール、ソルビトール、ジプロピレングリコール、プロピレングリコール等が挙げられる。これらは単独でもしくは二種以上併せて用いられる。 Examples of the humectant include hyaluronic acid, squalane, glycerin, 1,3-butylene glycol, sorbitol, dipropylene glycol, propylene glycol and the like. These may be used alone or in combination of two or more.
有機微粒子としては、例えば、ポリエチレンエマルション、スチレン−ブタジエンラテックス、アクリルエマルジョン、ウレタンエマルジョン等が挙げられる。これらは単独で用いてもよく、二種以上併せて用いてもよい。 Examples of the organic fine particles include polyethylene emulsion, styrene-butadiene latex, acrylic emulsion, urethane emulsion and the like. These may be used alone or in combination of two or more.
無機微粒子としては、例えば、酸化チタン、シリカ化合物、カーボンブラック等が挙げられる。これらは単独で用いてもよく、二種以上併せて用いてもよい。 Examples of the inorganic fine particles include titanium oxide, a silica compound, and carbon black. These may be used alone or in combination of two or more.
防腐剤としては、例えば、メチルパラベン、エチルパラベン、ブチルパラベン、プロピルパラベン、ベンジルパラベン等のパラベンが挙げられ、これらは単独で用いてもよく、二種以上併せて用いてもよい。 Examples of the preservative include parabens such as methyl paraben, ethyl paraben, butyl paraben, propyl paraben, and benzyl paraben, and these may be used alone or in combination of two or more.
消臭剤及び香料としては、例えば、Dリモネン、デシルアルデヒド、メントン、プレゴン、オイゲノール、シンナムアルデヒド、ベンズアルデヒド、メントール、ペパーミント油、レモン油、オレンジ油、植物(例えば、カタバミ、ドクダミ、ツガ、イチョウ、クロマツ、カラマツ、アカマツ、キリ、ヒイラギモクセイ、ライラック、キンモクセイ、フキ、ツワブキ、レンギョウ等)の各器官から水、親水性有機溶剤で抽出された消臭有効成分等が挙げられる。これらは単独で用いてもよく、二種以上併せて用いてもよい。 Deodorants and fragrances include, for example, D limonene, decyl aldehyde, menthone, pulegone, eugenol, cinnamaldehyde, benzaldehyde, menthol, peppermint oil, lemon oil, orange oil, plants (e.g. Deodorant active ingredients extracted from water, hydrophilic organic solvents, etc. from various organs of black pine, larch, red pine, gill, holly mushroom, lilac, goldfinch, Japanese cypress, Japanese agate, forsythia and the like. These may be used alone or in combination of two or more.
有機溶媒としては、例えば、水に可溶するアルコール類(メタノール、エタノール、イソプロパノール、イソブタノール、sec−ブタノール、tert−ブタノール、メチルセロソルブ、エチルセロソルブ、エチレングリコール、グリセリン等)、エーテル類(エチレングリコールジメチルエーテル、1,4−ジオキサン、テトラヒドロフラン等)、ケトン類(アセトン、メチルエチルケトン)、N,N−ジメチルホルムアミド、N,N−ジメチルアセトアミド、ジメチルスルホキサイド等が挙げられる。これらは単独で用いてもよく、二種以上併せて用いてもよい。 Examples of the organic solvent include water-soluble alcohols (methanol, ethanol, isopropanol, isobutanol, sec-butanol, tert-butanol, methyl cellosolve, ethyl cellosolve, ethylene glycol, glycerin, etc.), ethers (ethylene glycol) Dimethyl ether, 1,4-dioxane, tetrahydrofuran and the like), ketones (acetone, methyl ethyl ketone), N, N-dimethylformamide, N, N-dimethylacetamide, dimethyl sulfoxide and the like. These may be used alone or in combination of two or more.
機能成分としては、例えば、パラアミノ安息香酸及びその誘導体、ホモメチル−7N−アセチルアラントイラニレート、ブチルメトキシベンゾイルメタン、ジ−パラメトキシケイ皮酸−モノ−2−エチルへキサン酸グリセリル、オクチルシンナメート等のパラメトキシケイ皮酸誘導体、アミノサリシレート等のサリチル酸誘導体、2,4−ジヒドロキシベンゾフェノン等のベンゾフェノリン誘導体、ジメトキシベンジリデンジオキソイミダゾリンプロピオン酸エチルヘキシル、酢酸液状ラノリン、コガネバナ根抽出エキス、トリアニリノ−p−カルボエチルヘキシルオキシ−トリアジン等の紫外線吸収剤;アルブチン、コウジ酸、リン酸アスコルビン酸マグネシウム等のアスコルビン酸及びその誘導体、グルタチオン、甘草エキス、チョウジエキス、茶抽出物、アスタキサンチン、牛胎盤エキス、トコフェロール及びその誘導体、トラネキサム酸及びその塩、アズレン、γ−ヒドロキシ酪酸等の美白成分;エチレンジアミン四酢酸及びその塩類、リン酸、アスコルビン酸、コハク酸、グルコン酸、ポリリン酸塩類、メタリン酸塩類等の金属イオン封鎖剤;ビタミンA及びその誘導体、ビタミンB6塩酸塩、ビタミンB6トリパルミテート、ビタミンB6ジオクタノエート、ビタミンB2及びその誘導体等のビタミンB類、アスコルビン酸、アスコルビン酸硫酸エステル、及びアスコルビン酸リン酸エステル等のビタミンC類、α−トコフェロール、β−トコフェロール及びγ−トコフェロール等のビタミンE類、ビタミンD類、ビタミンH並びにパントテン酸等のビタミン類;ニコチン酸アミド、ニコチン酸ベンジル、γ−オリザノール、アラントイン、グリチルチン酸(塩)グリチルレチン酸及びその誘導体、ヒノキチオール、ムシジン、ビサボロール、ユーカリプトール、チモールイソシトール、サポニン類(キラヤサポニン、アズキサポニン、ヘチマサポニン等)、トラネキサム酸、パントテルエチルエーテル、エチニルエストラジオール、セファランジン、プラセンタエキス、センブリエキス、セファランチン、ビタミンE及びその誘導体、ガンマ−オリザノール等の血行促進剤;トウガラシチンキ、ショオウキョウチンキ、カンタリスチンキ、ニコチン酸ベンジルエステル等の局所刺激剤;アミノ酸等の栄養剤;グリチルレチン酸、グリチルリチン酸誘導体、塩化カルプロニウム、ノニル酸ワニルアミド、アラントイン、アズレン、アミノカプロン酸、ヒドロコルチゾン等の抗炎症剤;酸化亜鉛、硫酸亜鉛、アラントインヒドロキシアルミニウム、塩化アルミニウム、スルホ石炭酸亜鉛、タンニン酸等の収斂剤;メントール、カンフル等の清涼剤;抗ヒスタミン剤;高分子シリコーン、環状シリコーン等のシリコーン系物質;BHA、BHT、没食子酸、NDGA、トコフェロール、フィチン酸等の酸化防止剤;サッカロマイセス等の酵母、糸状菌、バクテリア、牛胎盤、人胎盤、酵母、コラーゲン、牛乳由来タンパク、小麦、大豆、牛血液、豚血液、鶏冠、カミツレ、きゅうり、米、シアバター、シラカバ、茶、トマト、にんにく、ハマメリス、バラ、ヘチマ、ホップ、桃、杏、レモン、キウイ、どくだみ、トウガラシ、クララ、ギシギシ、コウホネ、セージ、ノコギリ草、ゼニアオイ、センキュウ、センブリ、タイム、トウキ、トウヒ、バーチ、スギナ、マロニエ、ユキノシタ、アルニカ、ユリ、ヨモギ、シャクヤク、アロエ、アロエベラ、オウゴン、オウバク、コウカ、ベニバナ、サンシン、シコン、タイソウ、チンピ、ニンジン、ヨクイニン、ハトムギ、クチナシ、サワラ等の動植物、微生物及びその一部から有機溶媒、アルコール、多価アルコール、水、水性アルコール等で抽出又は加水分解して得た天然エキス;色素類;カチオン化セルロース、カルボキシビニルポリマー、カルボニルピロリドン、ポリビニルピロリドン−酢酸ビニル共重合体、キサンタンガム、ヒドロキシエチルセルロース等の高分子添加剤;キレート剤;トリエタノールアミンや水酸化カリウム、ホウ砂等のアルカリ等が挙げられる。これらは単独で用いてもよく、二種以上併せて用いてもよい。 Functional components include, for example, paraaminobenzoic acid and derivatives thereof, homomethyl-7N-acetylalanthranilate, butylmethoxybenzoylmethane, di-paramethoxycinnamic acid-mono-2-ethylhexylate glyceryl, octylcinnamate Paramethoxycinnamate derivatives such as, salicylic acid derivatives such as aminosalicylate, benzophenoline derivatives such as 2,4-dihydroxybenzophenone, dimethoxybenzylidene dioxoimidazoline propionate ethylhexyl, acetic acid liquid lanolin, coganebana root extract extract, trianilino-p UV absorbers such as carboethylhexyloxy-triazine; ascorbic acid and its derivatives such as arbutin, kojic acid, magnesium ascorbate phosphate, glutathione, licorice extract, clove Whitening ingredients such as kiss, tea extract, astaxanthin, bovine placenta extract, tocopherol and derivatives thereof, tranexamic acid and salts thereof, azulene and γ-hydroxybutyric acid; ethylenediaminetetraacetic acid and salts thereof, phosphoric acid, ascorbic acid, succinic acid, Sequestering agents such as gluconic acid, polyphosphates, metaphosphates; vitamin B and its derivatives, vitamin B such as vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 and its derivatives, ascorbine Vitamins such as acid, ascorbic acid sulfate and ascorbic acid phosphate, vitamin E such as α-tocopherol, β-tocopherol and γ-tocopherol, vitamin D such as vitamin D, vitamin H and pantothenic acid; nicotine Acid amide, benzyl nicotinate, γ-oryzanol, allantoin, glycyrrhizic acid (salt) glycyrrhetinic acid and its derivatives, hinokitiol, mucidin, bisabolol, eucalyptol, thymol isositol, saponins (Quillaja saponin, azoxaponin, hetimasaponin Etc.), tranexamic acid, pantothel ethyl ether, ethinyl estradiol, cephalandin, placenta extract, assembly extract, cephalanthin, vitamin E and its derivatives, gamma-oryzanol and other blood circulation promoters; Local stimulants such as benzyl nicotinate; nutrients such as amino acids; glycyrrhetinic acid, glycyrrhizic acid derivatives, carpronium chloride, nonylic acid vanillamide, allanto Anti-inflammatory agents such as zinc, azulene, aminocaproic acid and hydrocortisone; astringents such as zinc oxide, zinc sulfate, allantoin hydroxyaluminum, aluminum chloride, zinc sulfococolate and tannic acid; refreshing agents such as menthol and camphor; antihistamines; Silicone substances such as silicone and cyclic silicone; antioxidants such as BHA, BHT, gallic acid, NDGA, tocopherol and phytic acid; yeasts such as Saccharomyces, filamentous fungi, bacteria, cow placenta, human placenta, yeast, collagen, milk Protein, wheat, soybean, cow blood, pig blood, chicken crown, chamomile, cucumber, rice, shea butter, birch, tea, tomato, garlic, hamamelis, rose, loofah, hop, peach, apricot, lemon, kiwi, dodomi, Capsicum, Clara, Gigigishi, Kouhone, Se , Sawtooth grass, mallow, senkyu, assembly, thyme, spruce, spruce, birch, horsetail, maroonier, saxifrage, arnica, lily, mugwort, peonies, aloe, aloe vera, oxon, grasshopper, safflower, sanshin, shikon, Natural extract obtained by extracting or hydrolyzing organic solvents, alcohols, polyhydric alcohols, water, aqueous alcohols, etc. from animals and plants, microorganisms and parts thereof such as Taisou, Chimpi, Carrot, Yokuinin, pearl barley, gardenia, Sawara; Polymer additives such as cationized cellulose, carboxyvinyl polymer, carbonyl pyrrolidone, polyvinyl pyrrolidone-vinyl acetate copolymer, xanthan gum, hydroxyethyl cellulose; chelating agents; alethanol such as triethanolamine, potassium hydroxide, borax Li and the like. These may be used alone or in combination of two or more.
機能性添加剤の配合量は、機能性添加剤が目的とする効果を発現するために必要な配合量で用いることが好ましく、特に限定されるものではない。 The compounding amount of the functional additive is preferably not particularly limited, and is preferably used in an amount necessary for the functional additive to exhibit the intended effect.
本発明の組成物は、例えば、上記リンオキソ酸基が導入された微細繊維状セルロース及び水とともに、必要に応じて機能性添加剤を適宜配合し、これらを混合処理等することにより得ることができる。微細繊維状セルロースとしては、上記で得られたスラリー状のものをそのまま用いてもよいし、スラリーを乾燥したものを用いてもよい。 The composition of the present invention can be obtained, for example, by appropriately blending a functional additive as necessary together with the fine fibrous cellulose introduced with the above-mentioned phosphoroxo acid group and water, and mixing them. . As the fine fibrous cellulose, the slurry obtained above may be used as it is, or a dried slurry may be used.
混合処理としては、例えば、真空ホモミキサー、ディスパー、プロペラミキサー、ニーダー等の各種混練器、各種粉砕機、ブレンダー、ホモジナイザー、超音波ホモジナイザー、コロイドミル、ペブルミル、ビーズミル粉砕機、高圧ホモジナイザーや超高圧ホモジナイザー等を用いた混合処理が挙げられる。 Examples of the mixing process include various kneaders such as vacuum homomixers, dispersers, propeller mixers, kneaders, various pulverizers, blenders, homogenizers, ultrasonic homogenizers, colloid mills, pebble mills, bead mill pulverizers, high-pressure homogenizers, and ultrahigh-pressure homogenizers. And the like using a mixing process.
このようにして得られる本発明の組成物の粘度は、好ましくは300mPa・s以上であり、より好ましくは400〜2000mPa・sの範囲である。ここで、粘度は、B型粘度計(No.2及びNo.3ローター)(BLOOKFIELD社製、アナログ粘度計T−LVT)を用いて回転数60rpm(3分)で測定した値をさす。 The viscosity of the composition of the present invention thus obtained is preferably 300 mPa · s or more, and more preferably in the range of 400 to 2000 mPa · s. Here, the viscosity indicates a value measured at a rotational speed of 60 rpm (3 minutes) using a B-type viscometer (No. 2 and No. 3 rotor) (BLOOKFIELD, analog viscometer T-LVT).
本発明の組成物における、リンオキソ酸基が導入された微細繊維状セルロースの含有量は、組成物全体に対し、好ましくは0.1〜5.0質量%、より好ましくは0.2〜1.5質量%である。微細繊維状セルロースの含有量を上記範囲内とすることにより、塩やイオン性界面活性剤等の共存下でも、また酸性条件下でも、高い粘性を保持することができる。また、著しく粘度が上昇し、組成物のハンドリング性(ポンプで送るなど)が悪化するのを防止できる。 In the composition of the present invention, the content of the fine fibrous cellulose into which the phosphorus oxo acid group is introduced is preferably 0.1 to 5.0% by mass, more preferably 0.2 to 1%, based on the entire composition. 5% by mass. By setting the content of the fine fibrous cellulose within the above range, high viscosity can be maintained even in the presence of a salt, an ionic surfactant, or the like or under acidic conditions. Moreover, it can prevent that a viscosity raises remarkably and the handleability (pumping etc.) of a composition deteriorates.
ここで、酸性条件とは、pH7未満、好ましくはpH6以下、例えば、pH2〜5の条件をいう。したがって、一実施形態において本発明の組成物は、酸性、好ましくはpH3〜5で、400mPa・s以上の粘度を有する。 Here, the acidic condition refers to a condition of less than pH 7, preferably 6 or less, for example, pH 2-5. Accordingly, in one embodiment, the composition of the present invention is acidic, preferably pH 3-5, and has a viscosity of 400 mPa · s or higher.
本発明の組成物が、上記微細繊維状セルロースと水のみからなる場合は、水の配合量は、組成物全体から微細繊維状セルロースの含有量(0.1〜5.0質量%)を除いた残量(95質量%〜99.9質量%)となる。また、本発明の組成物が、微細繊維状セルロース及び水以外に、機能性添加剤等を含有する場合には、組成物全体から微細繊維状セルロースの含有量(0.1〜5.0質量%)と、機能性添加剤等の含有量を除いた残量が、水の配合量となる。 When the composition of the present invention is composed of only the above-mentioned fine fibrous cellulose and water, the water content excludes the content of fine fibrous cellulose (0.1 to 5.0% by mass) from the entire composition. Remaining amount (95 mass% to 99.9 mass%). Moreover, when the composition of this invention contains a functional additive etc. in addition to fine fibrous cellulose and water, content (0.1-5.0 mass) of fine fibrous cellulose from the whole composition. %) And the remaining amount excluding the content of the functional additive or the like becomes the blending amount of water.
<化粧料組成物>
一実施形態において本発明の組成物は、化粧料組成物である。本発明の化粧料組成物は、好ましくは300mPa・s以上、より好ましくは400〜50000mPa・sの粘度を有する。本発明の化粧料組成物は、例えば、クリーム状、ゲル状、乳液状の剤形を有する。本発明の微細繊維状セルロースを化粧料組成物に配合することにより、少ない量で粘度の調整を容易に実施でき、使用感に優れた化粧料組成物を得ることができる。また、皮膚に塗布した際のべとつき感や、ざらつき感がない使用感を得ることができる。
<Cosmetic composition>
In one embodiment, the composition of the present invention is a cosmetic composition. The cosmetic composition of the present invention preferably has a viscosity of 300 mPa · s or more, more preferably 400 to 50000 mPa · s. The cosmetic composition of the present invention has, for example, a cream form, a gel form, and an emulsion form. By blending the fine fibrous cellulose of the present invention into a cosmetic composition, it is possible to easily adjust the viscosity with a small amount and obtain a cosmetic composition having an excellent usability. In addition, a feeling of stickiness when applied to the skin and a feeling of use without a feeling of roughness can be obtained.
本発明の化粧料組成物は、具体的には、化粧水、乳液、コールドクリーム、バニシングクリーム、マッサージクリーム、エモリエントクリーム、クレンジングクリーム、美容液、パック、ファンデーション、サンスクリーン化粧料、サンタン化粧料、モイスチャークリーム、ハンドクリーム、美白乳液、各種ローション等の皮膚用化粧料、シャンプー、リンス、ヘアコンディショナー、リンスインシャンプー、ヘアスタイリング剤(ヘアフォーム、ジェル状整髪料等)、ヘアトリートメント剤(ヘアクリーム、トリートメントローション等)、染毛剤やローションタイプの育毛剤又は養毛剤等の毛髪用化粧料、さらにはハンドクリーナーのような洗浄剤、プレシェーブローション、アフターシェーブローション、芳香剤や歯磨剤、軟膏、貼布剤等の形態でありうる。 Specifically, the cosmetic composition of the present invention is a lotion, emulsion, cold cream, burnishing cream, massage cream, emollient cream, cleansing cream, serum, pack, foundation, sunscreen cosmetic, suntan cosmetic, Moisture cream, hand cream, whitening milk, various cosmetics for skin, shampoo, rinse, hair conditioner, rinse-in shampoo, hair styling agent (hair foam, gel hair conditioner, etc.), hair treatment agent (hair cream, treatment Lotion, etc.), hair cosmetics such as hair dyes and lotion type hair restorers or hair nourishing agents, as well as detergents such as hand cleaners, pre-shave lotions, after-shave lotions, fragrances, dentifrices, ointments, and pastes It may be in the form of an equal.
本発明の増粘剤は、例えば、医薬品、化粧品、食品、建築分野などの工業製品を含む広汎な分野に利用できる。このような耐酸性のある微細繊維状セルロースからなる水溶性増粘剤は、これまで、医薬品、化粧品、食品、建築分野などの工業製品を含む広汎な分野において存在しない。 The thickener of the present invention can be used in a wide range of fields including industrial products such as pharmaceuticals, cosmetics, foods, and construction fields. Such a water-soluble thickener composed of acid-resistant fine fibrous cellulose has not existed in a wide range of fields including industrial products such as pharmaceuticals, cosmetics, foods, and buildings.
以下、本発明を実施例によりさらに詳細に説明するが、本発明はこれらの例によって何ら限定されるものではない。実施例中、%は特に断らない限り、質量%を示す。 EXAMPLES Hereinafter, although an Example demonstrates this invention further in detail, this invention is not limited at all by these examples. In Examples,% indicates mass% unless otherwise specified.
(製造例1)
リン酸化微細セルロース(微細セルロース1)の調製:
尿素100g、リン酸二水素ナトリウム二水和物55.3g、リン酸水素二ナトリウム41.3gを109gの水に溶解させてリン酸化試薬を調製した。
(Production Example 1)
Preparation of phosphorylated fine cellulose (fine cellulose 1):
A phosphorylating reagent was prepared by dissolving 100 g of urea, 55.3 g of sodium dihydrogen phosphate dihydrate, and 41.3 g of disodium hydrogen phosphate in 109 g of water.
乾燥した針葉樹晒クラフトパルプの抄上げシートをカッターミル及びピンミルで処理し、綿状の繊維にした。この綿状の繊維を絶乾質量で100g取り、リン酸化試薬をスプレーでまんべんなく吹きかけた後、手で練り合わせ、薬液含浸パルプを得た。 The dried softwood bleached kraft pulp paper was processed with a cutter mill and a pin mill to form cotton-like fibers. 100 g of this cotton-like fiber was taken in an absolutely dry mass, and the phosphorylating reagent was sprayed evenly with a spray, and then kneaded by hand to obtain a chemical-impregnated pulp.
得られた薬液含浸パルプを140℃に加熱したダンパー付きの送風乾燥機にて、80分間加熱処理し、リン酸化パルプを得た。 The obtained chemical-impregnated pulp was heat-treated for 80 minutes in a blower dryer with a damper heated to 140 ° C. to obtain phosphorylated pulp.
得られたリン酸化パルプをパルプ質量で100g分取し、10Lのイオン交換水を注ぎ、攪拌して均一に分散させた後、濾過脱水して、脱水シートを得る工程を2回繰り返した。次いで、得られた脱水シートを10Lのイオン交換水で希釈し、攪拌しながら、1Nの水酸化ナトリウム水溶液を少しずつ添加し、pHが12〜13のパルプスラリーを得た。その後、このパルプスラリーを脱水し、脱水シートを得た後、10Lのイオン交換水を注ぎ、攪拌して均一に分散させた後、濾過脱水して、脱水シートを得る工程を2回繰り返した。 100 g of the obtained phosphorylated pulp was collected by pulp mass, poured with 10 L of ion exchange water, stirred and dispersed uniformly, and then subjected to filtration and dehydration to obtain a dehydrated sheet twice. Next, the obtained dehydrated sheet was diluted with 10 L of ion-exchanged water, and a 1N sodium hydroxide aqueous solution was added little by little while stirring to obtain a pulp slurry having a pH of 12 to 13. Thereafter, the pulp slurry was dehydrated to obtain a dehydrated sheet, and 10 L of ion-exchanged water was poured, and the mixture was stirred and dispersed uniformly, followed by filtration and dehydration to obtain a dehydrated sheet twice.
脱水洗浄後に得られたセルロース繊維にイオン交換水を添加し、0.5質量%のスラリーを調製した。このスラリーを、解繊処理装置(エムテクニック社製、クレアミックス−11S)を用いて、6900回転/分の条件で180分間解繊処理した。その後、イオン交換水を添加してスラリー固形分濃度0.25質量%に調整し、冷却高速遠心分離機(コクサン社、H−2000B、RNローター、CKN1コレクタ)を用いて連続遠心を行った。この時、解繊液を送液ポンプにて100ml/分で送液し、18000G条件で遠心分離を行った。得られた上澄み液を回収し、微細セルロース繊維含有スラリーを得た。得られた微細セルロース繊維を「微細セルロース1」とした。また、X線回折により、セルロースはセルロースI型結晶を維持しており、FT−IRによる赤外線吸収スペクトルの測定により、1230〜1290cm−1にリン酸基に基づく吸収が見られ、リン酸基の付加が確認された。よって、得られたリン酸オキソ酸導入セルロースは、セルロースのヒドロキシ基の一部が下記構造式(2)の官能基で置換されたものであった。 Ion exchange water was added to the cellulose fiber obtained after dehydration and washing to prepare a 0.5% by mass slurry. The slurry was defibrated for 180 minutes using a defibrating apparatus (Cleamix-11S, manufactured by M Technique Co., Ltd.) at 6900 rpm. Thereafter, ion-exchanged water was added to adjust the slurry solid content concentration to 0.25% by mass, and continuous centrifugation was performed using a cooling high-speed centrifuge (Kokusan, H-2000B, RN rotor, CKN1 collector). At this time, the defibrated solution was fed at a rate of 100 ml / min with a feed pump and centrifuged under 18000G conditions. The obtained supernatant was collected to obtain a slurry containing fine cellulose fibers. The obtained fine cellulose fiber was designated as “fine cellulose 1”. In addition, by X-ray diffraction, cellulose maintains cellulose I-type crystals. Absorption based on a phosphate group is observed at 1230 to 1290 cm −1 by measurement of an infrared absorption spectrum by FT-IR. The addition was confirmed. Therefore, the obtained phosphoric acid oxoacid-introduced cellulose was one in which a part of the hydroxy group of the cellulose was substituted with the functional group of the following structural formula (2).
(製造例2)
カルボキシル化微細セルロース(微細セルロース2)の調製:
乾燥質量200g相当分の未乾燥の針葉樹晒クラフトパルプとTEMPO2.5gと、臭化ナトリウム25gとを水1500mlに分散させた後、13質量%次亜塩素酸ナトリウム水溶液を、1.0gのパルプに対して次亜塩素酸ナトリウムの量が5.4mmolになるように加えて反応を開始した。反応中は0.5Mの水酸化ナトリウム水溶液を滴下してpHを10〜11に保ち、pHに変化が見られなくなった時点で反応終了と見なした。
その後、このパルプスラリーを脱水し、脱水シートを得た後、10Lのイオン交換水を注ぎ、攪拌して均一に分散させた後、濾過脱水して、脱水シートを得る工程を2回繰り返した。
(Production Example 2)
Preparation of carboxylated fine cellulose (fine cellulose 2):
After dispersing undried softwood bleached kraft pulp equivalent to a dry mass of 200 g, TEMPO 2.5 g, and sodium bromide 25 g in water 1500 ml, 13 mass% sodium hypochlorite aqueous solution was added to 1.0 g of pulp. The reaction was started by adding sodium hypochlorite so that the amount of sodium hypochlorite was 5.4 mmol. During the reaction, a 0.5 M aqueous sodium hydroxide solution was added dropwise to maintain the pH at 10 to 11, and the reaction was considered complete when no change in pH was observed.
Thereafter, the pulp slurry was dehydrated to obtain a dehydrated sheet, and 10 L of ion-exchanged water was poured, and the mixture was stirred and dispersed uniformly, followed by filtration and dehydration to obtain a dehydrated sheet twice.
脱水洗浄後に得られたセルロース繊維にイオン交換水を添加し、0.5質量%のスラリーを調製した。このスラリーを、解繊処理装置(エムテクニック社製、クレアミックス−11S)を用いて、6900回転/分の条件で180分間解繊処理した。その後、冷却高速遠心分離機(コクサン社、H−2000B、RNローター、CKN1コレクタ)を用いて連続遠心を行った。この時、解繊液を送液ポンプにて100ml/分で送液し、18000G条件で遠心分離を行った。得られた上澄み液を回収し、微細セルロース繊維含有スラリーを得た。得られた微細セルロース繊維を「微細セルロース2」とした。また、X線回折により、セルロースはセルロースI型結晶を維持しており、FT−IRによる赤外線吸収スペクトルの測定により、1730cm−1にカルボキシル基に基づく吸収が見られ、カルボキシル基の付加が確認された。 Ion exchange water was added to the cellulose fiber obtained after dehydration and washing to prepare a 0.5% by mass slurry. The slurry was defibrated for 180 minutes using a defibrating apparatus (Cleamix-11S, manufactured by M Technique Co., Ltd.) at 6900 rpm. Then, continuous centrifugation was performed using a cooling high-speed centrifuge (Kokusan, H-2000B, RN rotor, CKN1 collector). At this time, the defibrated solution was fed at a rate of 100 ml / min with a feed pump and centrifuged under 18000G conditions. The obtained supernatant was collected to obtain a slurry containing fine cellulose fibers. The obtained fine cellulose fiber was designated as “fine cellulose 2”. Moreover, by X-ray diffraction, the cellulose maintained the cellulose I type crystal | crystallization, absorption based on a carboxyl group was seen by 1730cm < -1 > by the measurement of the infrared absorption spectrum by FT-IR, and addition of a carboxyl group was confirmed. It was.
(試験例1)
セルロース表面のリン酸基量測定:
製造例1にて作製した微細セルロース1のリン酸基量を測定した。絶乾質量で0.04g程度の固形分を含む微細セルロース繊維含有スラリーを分取し、イオン交換水を用いて50g程度に希釈した。この溶液を、マグネチックスターラーを用いて撹拌しながら、0.01Nの水酸化ナトリウム水溶液を加えていったときの電気伝導度の値の変化を測定し、その値が極小となる時の0.01N水酸化ナトリウム水溶液の滴下量を滴定終点における滴下量とした。
(Test Example 1)
Measurement of phosphate group on cellulose surface:
The amount of phosphate groups of fine cellulose 1 produced in Production Example 1 was measured. A fine cellulose fiber-containing slurry containing about 0.04 g of solid content in an absolutely dry mass was collected and diluted to about 50 g using ion-exchanged water. While this solution was stirred using a magnetic stirrer, the change in the value of electrical conductivity when a 0.01N sodium hydroxide aqueous solution was added was measured. The dropping amount of the 01N sodium hydroxide aqueous solution was defined as the dropping amount at the titration end point.
この時、セルロース表面の置換基量XはX(mmol/g)=0.01(mol/l)×V(ml)/W(g)で表される。ここで、V:0.01N水酸化ナトリウム水溶液の滴下量(ml)、W:微細セルロース繊維含有スラリーが含む固形分(g)である。測定結果を表1に示す。 At this time, the amount X of substituents on the cellulose surface is represented by X (mmol / g) = 0.01 (mol / l) × V (ml) / W (g). Here, V: A dripping amount (ml) of 0.01N sodium hydroxide aqueous solution, W: Solid content (g) contained in the slurry containing fine cellulose fibers. The measurement results are shown in Table 1.
セルロース表面のカルボキシル基量測定:
製造例2にて作製した微細セルロース2のカルボキシル基量を測定した。絶乾質量で0.04g程度の固形分を含む微細セルロース繊維含有スラリーを分取し、イオン交換水を用いて50g程度に希釈した。この溶液を、マグネチックスターラーを用いて撹拌しながら、0.01Nの水酸化ナトリウム水溶液を加えていったときの電気伝導度の値の変化を測定し、その値が極小となる時の0.01N水酸化ナトリウム水溶液の滴下量を滴定終点における滴下量とした。
Measurement of carboxyl group content on cellulose surface:
The amount of carboxyl groups of fine cellulose 2 produced in Production Example 2 was measured. A fine cellulose fiber-containing slurry containing about 0.04 g of solid content in an absolutely dry mass was collected and diluted to about 50 g using ion-exchanged water. While this solution was stirred using a magnetic stirrer, the change in the value of electrical conductivity when a 0.01N sodium hydroxide aqueous solution was added was measured. The dropping amount of the 01N sodium hydroxide aqueous solution was defined as the dropping amount at the titration end point.
この時、セルロース表面の置換基量XはX(mmol/g)=0.005(mol/l)×V(ml)/W(g)で表される。ここで、V:0.01N水酸化ナトリウム水溶液の滴下量(ml)、W:微細セルロース繊維含有スラリーが含む固形分(g)である。測定結果を表1に示す。 At this time, the amount X of substituents on the cellulose surface is represented by X (mmol / g) = 0.005 (mol / l) × V (ml) / W (g). Here, V: A dripping amount (ml) of 0.01N sodium hydroxide aqueous solution, W: Solid content (g) contained in the slurry containing fine cellulose fibers. The measurement results are shown in Table 1.
粘度の測定:
得られた各試料を25℃にてB型粘度計(No.2及びNo.3ローター)(BLOOKFIELD社製、アナログ粘度計T−LVT)を用いて回転数60rpm(3分)で粘度を測定した。100mM塩酸水溶液を調製し、1mL(0.1mM)ずつ加えては粘度を測定した。測定結果を表1に示す。
Viscosity measurement:
Viscosity of each obtained sample was measured at a rotational speed of 60 rpm (3 minutes) at 25 ° C. using a B-type viscometer (No. 2 and No. 3 rotor) (manufactured by BLOOKFIELD, analog viscometer T-LVT). did. A 100 mM hydrochloric acid aqueous solution was prepared, and 1 mL (0.1 mM) was added to measure the viscosity. The measurement results are shown in Table 1.
数平均繊維径の測定:
解繊パルプスラリーの上澄み液を濃度0.01〜0.1質量%に水で希釈し、親水化処理したカーボングリッド膜に滴下した。乾燥後、酢酸ウラニルで染色し、透過型電子顕微鏡(日本電子社製、JEOL−2000EX)により観察し、幅4nm程度の微細繊維状セルロースになっていることを確認した。
Number average fiber diameter measurement:
The supernatant liquid of the defibrated pulp slurry was diluted with water to a concentration of 0.01 to 0.1% by mass and dropped onto a hydrophilic carbon grid membrane. After drying, it was stained with uranyl acetate and observed with a transmission electron microscope (manufactured by JEOL Ltd., JEOL-2000EX) to confirm that it was a fine fibrous cellulose having a width of about 4 nm.
(実施例1)
微細セルロース1と水と塩化ナトリウムを用いた組成物を調製した。微細セルロースを0.3質量%、塩化ナトリウム(機能性添加剤)を0.1質量%添加してスラリーとし、IKA社T25URTRA TURRAXホモジナイザーを用いて回転数10,000rpmで5分間攪拌して試料を得た。結果を表2に示す。
Example 1
A composition using fine cellulose 1, water and sodium chloride was prepared. Add 0.3% by weight of fine cellulose and 0.1% by weight of sodium chloride (functional additive) to make a slurry, and stir the sample for 5 minutes at 10,000 rpm using an IKA T25URTRA TURRAX homogenizer. Obtained. The results are shown in Table 2.
(比較例1)
微細セルロース1の代わりに微細セルロース2を用いた以外は実施例1と同様に行った。結果を表2に示す。
(Comparative Example 1)
It carried out similarly to Example 1 except having used the fine cellulose 2 instead of the fine cellulose 1. FIG. The results are shown in Table 2.
(実施例2)
塩化ナトリウムの代わりにドデシルベンゼンスルホン酸ナトリウムを1.0質量%添加した以外は実施例1と同様に行った。結果を表3に示す。
(Example 2)
The same procedure as in Example 1 was performed except that 1.0% by mass of sodium dodecylbenzenesulfonate was added instead of sodium chloride. The results are shown in Table 3.
(比較例2)
微細セルロース1の代わりに微細セルロース2を用いた以外は実施例2と同様に行った。結果を表3に示す。
(Comparative Example 2)
It carried out similarly to Example 2 except having used the fine cellulose 2 instead of the fine cellulose 1. FIG. The results are shown in Table 3.
(実施例3)
塩化ナトリウムの代わりにスクワランを10質量%添加した以外は実施例1と同様に行った。結果を表4に示す。
(Example 3)
The same procedure as in Example 1 was performed except that 10% by mass of squalane was added instead of sodium chloride. The results are shown in Table 4.
(比較例3)
微細セルロース1の代わりに微細セルロース2を用いた以外は実施例3と同様に行った。結果を表4に示す。
(Comparative Example 3)
It carried out similarly to Example 3 except having used the fine cellulose 2 instead of the fine cellulose 1. FIG. The results are shown in Table 4.
(実施例4)
塩化ナトリウムの代わりにグリセリンを10質量%添加した以外は実施例1と同様に行った。結果を表5に示す。
Example 4
It carried out similarly to Example 1 except having added 10 mass% of glycerol instead of sodium chloride. The results are shown in Table 5.
(比較例4)
微細セルロース1の代わりに微細セルロース2を用いた以外は実施例4と同様に行った。結果を表5に示す。
(Comparative Example 4)
It carried out similarly to Example 4 except having used the fine cellulose 2 instead of the fine cellulose 1. FIG. The results are shown in Table 5.
(実施例5)
塩化ナトリウムの代わりにメチルパラベンを0.3質量%添加した以外は実施例1と同様に行った。結果を表6に示す。
(Example 5)
The same procedure as in Example 1 was performed except that 0.3% by mass of methylparaben was added instead of sodium chloride. The results are shown in Table 6.
(比較例5)
微細セルロース1の代わりに微細セルロース2を用いた以外は実施例5と同様に行った。結果を表6に示す。
(Comparative Example 5)
It carried out similarly to Example 5 except having used the fine cellulose 2 instead of the fine cellulose 1. FIG. The results are shown in Table 6.
(実施例6)
塩化ナトリウムの代わりに疎水化酸化チタン(STV−455、チタン工業株式会社製)を1.0質量%添加した以外は実施例1と同様に行った。結果を表7に示す。
(Example 6)
It carried out similarly to Example 1 except having added 1.0 mass% of hydrophobized titanium oxide (STV-455, the titanium industry company make) instead of sodium chloride. The results are shown in Table 7.
(比較例6)
微細セルロース1の代わりに微細セルロース2を用いた以外は実施例6と同様に行った。結果を表7に示す。
(Comparative Example 6)
The same procedure as in Example 6 was performed except that fine cellulose 2 was used instead of fine cellulose 1. The results are shown in Table 7.
(実施例7)
塩化ナトリウムの代わりにアニオン性ポリエチレンエマルション(商品名:「E−2213」(平均粒子径:0.07μm)、東邦化学工業社製)を1.0質量%添加した以外は実施例1と同様に行った。結果を表8に示す。
(Example 7)
Anionic polyethylene emulsion (trade name: “E-2213” (average particle size: 0.07 μm), manufactured by Toho Chemical Industry Co., Ltd.) instead of sodium chloride was added in the same manner as in Example 1 except that 1.0% by mass was added. went. The results are shown in Table 8.
(比較例7)
微細セルロース1の代わりに微細セルロース2を用いた以外は実施例7と同様に行った。結果を表8に示す。
(Comparative Example 7)
It carried out similarly to Example 7 except having used the fine cellulose 2 instead of the fine cellulose 1. FIG. The results are shown in Table 8.
(実施例8)
塩化ナトリウムの代わりにエタノールを10質量%添加した以外は実施例1と同様に行った。結果を表9に示す。
(Example 8)
It carried out similarly to Example 1 except having added 10 mass% of ethanol instead of sodium chloride. The results are shown in Table 9.
(比較例8)
微細セルロース1の代わりに微細セルロース2を用いた以外は実施例8と同様に行った。結果を表9に示す。
(Comparative Example 8)
It carried out similarly to Example 8 except having used the fine cellulose 2 instead of the fine cellulose 1. FIG. The results are shown in Table 9.
(実施例9)
塩化ナトリウムの代わりにヒノキチオールを1.0質量%添加した以外は実施例1と同様に行った。結果を表10に示す。
Example 9
It carried out like Example 1 except having added 1.0 mass% of hinokitiol instead of sodium chloride. The results are shown in Table 10.
(比較例9)
微細セルロース1の代わりに微細セルロース2を用いた以外は実施例9と同様に行った。結果を表10に示す。
(Comparative Example 9)
It carried out similarly to Example 9 except having used the fine cellulose 2 instead of the fine cellulose 1. FIG. The results are shown in Table 10.
表2〜10に示すとおり、製造例1で作製したリン酸基を有する微細繊維状セルロースは機能性添加剤を配合した条件にて、比較例と比べて耐酸性に優れていることが分かった。 As shown in Tables 2 to 10, it was found that the fine fibrous cellulose having a phosphate group produced in Production Example 1 was superior in acid resistance as compared with the Comparative Example under the condition where the functional additive was blended. .
(実施例10及び比較例10)
表11に微細セルロース1又は微細セルロース2を用いた酸性染毛料の処方を示す。調製法は常法に従った。得られた各試料のpHは「表11」のとおりであり、ほぼ同程度であった。次に各試料の安定性及び使用感を評価した結果、実施例10は良好であった。これに対し、比較例10では粘度が低く、使用感に劣るものであった。
(Example 10 and Comparative Example 10)
Table 11 shows the formulation of acidic hair dyes using fine cellulose 1 or fine cellulose 2. The preparation method followed a conventional method. The pH of each of the obtained samples was as shown in “Table 11” and was substantially the same. Next, as a result of evaluating the stability and usability of each sample, Example 10 was good. On the other hand, in Comparative Example 10, the viscosity was low and the feeling in use was inferior.
(実施例11)
表12に微細セルロース1を使用したヘアジェルの処方を示す。常法により調製された実施例11はたれ落ちがない良好な使用感を示すヘアジェルであった。
(Example 11)
Table 12 shows the formulation of hair gel using fine cellulose 1. Example 11 prepared by a conventional method was a hair gel showing a good feeling of use without sagging.
本発明の増粘剤は、天然素材であるセルロース繊維を使用し、また、各種機能性添加剤との配合性にも優れているとともに、耐酸性を有することから、化粧品基材や、芳香剤のようなトイレタリー用品基材等として広く好適に利用することができる。 The thickener of the present invention uses cellulose fiber which is a natural material, and is excellent in blendability with various functional additives and has acid resistance. It can be widely and suitably used as a toiletry article base material.
Claims (8)
a、b、m、nは自然数であり(ただし、a=b×mである)、
α1、α2、・・・、αn及びα’のうちの少なくとも1つはO−であり、残りはR又はORであり、
Rは、各々独立して、水素原子、飽和−直鎖状炭化水素基、飽和−分岐鎖状炭化水素基、飽和−環状炭化水素基、不飽和−直鎖状炭化水素基、不飽和−分岐鎖状炭化水素基、芳香族基又はこれらの誘導基であり、
βは有機物又は無機物からなる1価以上の陽イオンである]
で表されるリンオキソ酸基で置換されたものである、請求項1又は2に記載の増粘剤。 The fine fibrous cellulose has a part of the hydroxy group of cellulose represented by the following structural formula (1):
a, b, m, and n are natural numbers (where a = b × m),
at least one of α1, α2,..., αn and α ′ is O − and the rest is R or OR;
Each R is independently a hydrogen atom, a saturated-linear hydrocarbon group, a saturated-branched hydrocarbon group, a saturated-cyclic hydrocarbon group, an unsaturated-linear hydrocarbon group, an unsaturated-branched group. A chain hydrocarbon group, an aromatic group or a derivative thereof,
β is a monovalent or higher cation made of an organic or inorganic substance]
The thickener according to claim 1 or 2, which is substituted with a phosphorus oxoacid group represented by the formula:
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014067659A JP6271318B2 (en) | 2014-03-28 | 2014-03-28 | Cellulose-based water-soluble thickener |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014067659A JP6271318B2 (en) | 2014-03-28 | 2014-03-28 | Cellulose-based water-soluble thickener |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015189698A JP2015189698A (en) | 2015-11-02 |
JP6271318B2 true JP6271318B2 (en) | 2018-01-31 |
Family
ID=54424522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014067659A Active JP6271318B2 (en) | 2014-03-28 | 2014-03-28 | Cellulose-based water-soluble thickener |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP6271318B2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109071681B (en) | 2016-03-31 | 2020-03-13 | 王子控股株式会社 | Method for producing fibrous cellulose and fibrous cellulose |
JP6728964B2 (en) * | 2016-05-18 | 2020-07-22 | 王子ホールディングス株式会社 | Thickener for battery electrode composition, battery electrode composition, battery electrode and battery |
KR102192310B1 (en) | 2016-08-10 | 2020-12-17 | 오지 홀딩스 가부시키가이샤 | Composition and sheet containing fibrous cellulose |
JP6404382B2 (en) * | 2017-02-28 | 2018-10-10 | 大王製紙株式会社 | Cellulose fine fiber and method for producing the same |
JP6963539B2 (en) * | 2017-02-28 | 2021-11-10 | 大王製紙株式会社 | Cellulose fine fibers and their manufacturing methods |
WO2018159743A1 (en) * | 2017-03-01 | 2018-09-07 | 王子ホールディングス株式会社 | Fibrous cellulose, fibrous cellulose-containing composition, fibrous cellulose liquid dispersion, and production method for fibrous cellulose |
JP7172033B2 (en) | 2017-03-01 | 2022-11-16 | 王子ホールディングス株式会社 | Fibrous Cellulose, Fibrous Cellulose-Containing Composition, Fibrous Cellulose Dispersion, and Method for Producing Fibrous Cellulose |
WO2018198162A1 (en) | 2017-04-24 | 2018-11-01 | 王子ホールディングス株式会社 | Thickening agent, composition, and sheet |
JP6299939B1 (en) * | 2017-04-24 | 2018-03-28 | 王子ホールディングス株式会社 | Thickener, composition and sheet |
JP7378198B2 (en) | 2017-05-15 | 2023-11-13 | 大王製紙株式会社 | Cellulose fine fiber and its manufacturing method |
JP6404415B1 (en) | 2017-07-24 | 2018-10-10 | 大王製紙株式会社 | Cellulose fine fiber-containing material, method for producing the same, and cellulose fine fiber dispersion |
JP6920260B2 (en) * | 2017-07-24 | 2021-08-18 | 大王製紙株式会社 | Cellulose fine fiber-containing material and its manufacturing method |
WO2021107147A1 (en) * | 2019-11-29 | 2021-06-03 | 王子ホールディングス株式会社 | Fibrous cellulose, fibrous cellulose dispersion, and sheet |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2744632B1 (en) * | 1996-02-13 | 1998-03-27 | Oreal | USE OF AN AQUEOUS SUSPENSION OF NATURALLY ORIGINAL MICROFIBRILLES FOR THE PREPARATION OF COSMETIC OR DERMATOLOGICAL COMPOSITIONS, COSMETIC OR DERMATOLOGICAL COMPOSITIONS AND APPLICATIONS |
JP4054412B2 (en) * | 1997-09-01 | 2008-02-27 | 花王株式会社 | Novel polysaccharide derivative, method for producing the same, and cosmetics containing the same |
US6602994B1 (en) * | 1999-02-10 | 2003-08-05 | Hercules Incorporated | Derivatized microfibrillar polysaccharide |
JP5798504B2 (en) * | 2011-11-18 | 2015-10-21 | 王子ホールディングス株式会社 | Method for producing fine fibrous cellulose, method for producing nonwoven fabric, fine fibrous cellulose, fine fibrous cellulose-containing slurry, nonwoven fabric, and composite |
-
2014
- 2014-03-28 JP JP2014067659A patent/JP6271318B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2015189698A (en) | 2015-11-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6271318B2 (en) | Cellulose-based water-soluble thickener | |
EP3473239B1 (en) | Foamable aerosol composition | |
US9801802B2 (en) | Viscous composition | |
JP5502712B2 (en) | Viscous aqueous composition | |
JP6229090B1 (en) | H-type carboxylated cellulose nanofiber | |
JP6308531B2 (en) | Topical skin preparation | |
JP2010037199A (en) | Cosmetic composition | |
US11382842B2 (en) | Cosmetic | |
WO2018116661A1 (en) | Acid-type carboxylated cellulose nanofibers | |
JP2012087256A (en) | Viscous aqueous composition, and method for producing the same | |
JP7254673B2 (en) | Emulsion composition, cosmetic composition, and method for producing emulsion composition | |
JP2017036217A (en) | Cosmetic | |
JP2016094358A (en) | Cellulose nanofiber dispersoid and cosmetic composition using the same | |
JP7220088B2 (en) | Oil-in-water emulsifiers and cosmetics | |
JP2017048142A (en) | Cosmetic | |
US11578142B2 (en) | Acid type carboxylated cellulose nanofiber | |
JP2016065031A (en) | Cosmetic composition | |
JP7164918B1 (en) | skin cleanser composition | |
JP2022032281A (en) | Shaving agent composition | |
JP2019131633A (en) | Aqueous composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160907 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20170512 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20170906 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170919 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20171120 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20171205 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20171227 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6271318 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313117 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313114 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |