JP6269888B1 - 医薬用途 - Google Patents
医薬用途 Download PDFInfo
- Publication number
- JP6269888B1 JP6269888B1 JP2017132416A JP2017132416A JP6269888B1 JP 6269888 B1 JP6269888 B1 JP 6269888B1 JP 2017132416 A JP2017132416 A JP 2017132416A JP 2017132416 A JP2017132416 A JP 2017132416A JP 6269888 B1 JP6269888 B1 JP 6269888B1
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- cyclopropane
- carbonyl
- amino
- dihydrospiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *c(c(*=C)c1)cc(NC(C(C2)C22c(cc(cc3)C(N*)=O)c3OCC2)=O)c1I* Chemical compound *c(c(*=C)c1)cc(NC(C(C2)C22c(cc(cc3)C(N*)=O)c3OCC2)=O)c1I* 0.000 description 6
- VMSMCGRYAKDGSK-FZMZJTMJSA-N CCOC([C@H](C1)[C@]11c2ccccc2OCC1)=O Chemical compound CCOC([C@H](C1)[C@]11c2ccccc2OCC1)=O VMSMCGRYAKDGSK-FZMZJTMJSA-N 0.000 description 1
- DARUQNLCRPXJBM-ADSBAMQRSA-N C[C@H]([C@@]1(C)c(cc(cc2)C(NC3CCOCC3)=O)c2OCC1)C(Nc1c(CCCC(O)=O)ccc(C#N)c1)=O Chemical compound C[C@H]([C@@]1(C)c(cc(cc2)C(NC3CCOCC3)=O)c2OCC1)C(Nc1c(CCCC(O)=O)ccc(C#N)c1)=O DARUQNLCRPXJBM-ADSBAMQRSA-N 0.000 description 1
- AIHJSSHJPYVNAK-FNZWTVRRSA-N Cc1nnc(-c(cc2)cc3c2OCC[C@@]3(C2)[C@@H]2C(Nc2c(CCCC(O)=O)ccc(C#N)c2)=O)[o]1 Chemical compound Cc1nnc(-c(cc2)cc3c2OCC[C@@]3(C2)[C@@H]2C(Nc2c(CCCC(O)=O)ccc(C#N)c2)=O)[o]1 AIHJSSHJPYVNAK-FNZWTVRRSA-N 0.000 description 1
- QUCWJFTVJFXUBN-DQUNLGLBSA-N N#Cc1cc(NC([C@H](C2)C22c3cc(-c4ncc[s]4)ccc3OCC2)=O)c(CCCC(O)=O)cc1 Chemical compound N#Cc1cc(NC([C@H](C2)C22c3cc(-c4ncc[s]4)ccc3OCC2)=O)c(CCCC(O)=O)cc1 QUCWJFTVJFXUBN-DQUNLGLBSA-N 0.000 description 1
- UOPNLVPPPONXJH-IADCTJSHSA-N N#Cc1cc(NC([C@H](C2)[C@]22c(cc(cc3)C(NC4CCCC4)=O)c3OCC2)=O)c(CCCC(O)=O)cc1 Chemical compound N#Cc1cc(NC([C@H](C2)[C@]22c(cc(cc3)C(NC4CCCC4)=O)c3OCC2)=O)c(CCCC(O)=O)cc1 UOPNLVPPPONXJH-IADCTJSHSA-N 0.000 description 1
Images
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017237151A JP6922712B2 (ja) | 2016-07-07 | 2017-12-11 | 医薬用途 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016134847 | 2016-07-07 | ||
| JP2016134847 | 2016-07-07 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017237151A Division JP6922712B2 (ja) | 2016-07-07 | 2017-12-11 | 医薬用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP6269888B1 true JP6269888B1 (ja) | 2018-01-31 |
| JP2018021013A JP2018021013A (ja) | 2018-02-08 |
Family
ID=61074787
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017132416A Active JP6269888B1 (ja) | 2016-07-07 | 2017-07-06 | 医薬用途 |
| JP2017237151A Expired - Fee Related JP6922712B2 (ja) | 2016-07-07 | 2017-12-11 | 医薬用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017237151A Expired - Fee Related JP6922712B2 (ja) | 2016-07-07 | 2017-12-11 | 医薬用途 |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JP6269888B1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113234012A (zh) * | 2021-06-01 | 2021-08-10 | 青岛化赫医药科技有限公司 | 一种3-甲氨基吡啶及其衍生物或其盐的制备方法 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230390303A1 (en) * | 2020-11-13 | 2023-12-07 | Ono Pharmaceutical Co., Ltd. | Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor |
| CN114790186A (zh) * | 2021-01-25 | 2022-07-26 | 武汉人福创新药物研发中心有限公司 | 作为ep4拮抗剂的稠环化合物及其制备方法和用途 |
| WO2022247862A1 (zh) * | 2021-05-28 | 2022-12-01 | 南京明德新药研发有限公司 | 苯并螺杂环衍生物及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU756333B2 (en) * | 1998-03-13 | 2003-01-09 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
| US6211197B1 (en) * | 1998-10-07 | 2001-04-03 | Merck Frosst Canada & Co. | Prostaglandin receptor ligands |
| AU2001278771A1 (en) * | 2000-08-22 | 2002-03-04 | Ono Pharmaceutical Co. Ltd. | Carboxylic acid derivatives, process for producing the same and drugs containingthe same as the active ingredient |
| GB0031302D0 (en) * | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Napthalene derivatives |
| KR20040022238A (ko) * | 2001-08-09 | 2004-03-11 | 오노 야꾸힝 고교 가부시키가이샤 | 카르복실산 유도체 화합물 및 그 화합물을 유효성분으로서 함유하는 약제 |
| WO2016088903A1 (en) * | 2014-12-05 | 2016-06-09 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
-
2017
- 2017-07-06 JP JP2017132416A patent/JP6269888B1/ja active Active
- 2017-12-11 JP JP2017237151A patent/JP6922712B2/ja not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113234012A (zh) * | 2021-06-01 | 2021-08-10 | 青岛化赫医药科技有限公司 | 一种3-甲氨基吡啶及其衍生物或其盐的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018087189A (ja) | 2018-06-07 |
| JP2018021013A (ja) | 2018-02-08 |
| JP6922712B2 (ja) | 2021-08-18 |
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| JP6269888B1 (ja) | 医薬用途 | |
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