JP6203372B2 - サルシン及び他の関連する真菌リボトキシンに由来するリボトキシン分子 - Google Patents

サルシン及び他の関連する真菌リボトキシンに由来するリボトキシン分子 Download PDF

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JP6203372B2
JP6203372B2 JP2016500564A JP2016500564A JP6203372B2 JP 6203372 B2 JP6203372 B2 JP 6203372B2 JP 2016500564 A JP2016500564 A JP 2016500564A JP 2016500564 A JP2016500564 A JP 2016500564A JP 6203372 B2 JP6203372 B2 JP 6203372B2
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sarcin
modified
mutation
molecule
ribotoxin
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JP2016512251A (ja
JP2016512251A5 (es
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カート アール． ゲールセン
カート アール． ゲールセン
ティモシー デイビッド ジョーンズ
ティモシー デイビッド ジョーンズ
フランシス ジョセフ カー
フランシス ジョセフ カー
アーロン ハーン
アーロン ハーン
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リサーチ コーポレーション テクノロジーズ インコーポレイテッド
リサーチ コーポレーション テクノロジーズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/2701—Endoribonucleases producing 3'-phosphomonoesters (3.1.27) rRNA endonuclease (3.1.27.10)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016500564A 2013-03-14 2014-03-03 サルシン及び他の関連する真菌リボトキシンに由来するリボトキシン分子 Active JP6203372B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361783589P 2013-03-14 2013-03-14
US61/783,589 2013-03-14
US201361902972P 2013-11-12 2013-11-12
US61/902,972 2013-11-12
PCT/US2014/020035 WO2014158770A1 (en) 2013-03-14 2014-03-03 Ribotoxin molecules derived from sarcin and other related fungal ribotoxins

Publications (3)

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JP2016512251A JP2016512251A (ja) 2016-04-25
JP2016512251A5 JP2016512251A5 (es) 2017-04-06
JP6203372B2 true JP6203372B2 (ja) 2017-09-27

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JP2016500564A Active JP6203372B2 (ja) 2013-03-14 2014-03-03 サルシン及び他の関連する真菌リボトキシンに由来するリボトキシン分子

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US (2) US9603911B2 (es)
EP (1) EP2971038B1 (es)
JP (1) JP6203372B2 (es)
AU (1) AU2014241891B2 (es)
CA (1) CA2903252C (es)
DK (1) DK2971038T3 (es)
ES (1) ES2765302T3 (es)
PL (1) PL2971038T3 (es)
PT (1) PT2971038T (es)
SI (1) SI2971038T1 (es)
WO (1) WO2014158770A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014158770A1 (en) * 2013-03-14 2014-10-02 Research Corporation Technologies, Inc. Ribotoxin molecules derived from sarcin and other related fungal ribotoxins
WO2017053290A1 (en) * 2015-09-23 2017-03-30 Research Corporation Technologies, Inc. Ribotoxin molecules derived from sarcin and other related fungal ribotoxins
EP4196593A1 (en) * 2020-08-17 2023-06-21 ATB Therapeutics Recombinant immunotoxin comprising a ribotoxin or rnase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU654563B2 (en) * 1991-07-24 1994-11-10 Imperial Chemical Industries Plc Proteins
US8114969B2 (en) * 2003-10-01 2012-02-14 Isis Innovation, Ltd. Immunotoxin derived from a recombinant human autoantibody and method of using thereof
EP3431503A1 (en) * 2005-01-12 2019-01-23 Proteonova, Inc. Method for making targeted therapeutic agents
WO2014158770A1 (en) * 2013-03-14 2014-10-02 Research Corporation Technologies, Inc. Ribotoxin molecules derived from sarcin and other related fungal ribotoxins

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Publication number Publication date
WO2014158770A1 (en) 2014-10-02
SI2971038T1 (sl) 2020-02-28
DK2971038T3 (da) 2020-01-27
PT2971038T (pt) 2020-01-20
CA2903252A1 (en) 2014-10-02
EP2971038B1 (en) 2019-12-04
JP2016512251A (ja) 2016-04-25
EP2971038A1 (en) 2016-01-20
PL2971038T3 (pl) 2020-04-30
AU2014241891B2 (en) 2017-09-14
ES2765302T3 (es) 2020-06-08
US9976131B2 (en) 2018-05-22
US20160106819A1 (en) 2016-04-21
EP2971038A4 (en) 2016-11-23
US20170204387A1 (en) 2017-07-20
AU2014241891A1 (en) 2015-09-17
US9603911B2 (en) 2017-03-28
CA2903252C (en) 2023-01-17

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