JP6195850B2 - 人体組織の微小石灰化の複数の異なるタイプの非侵襲的分類システム - Google Patents
人体組織の微小石灰化の複数の異なるタイプの非侵襲的分類システム Download PDFInfo
- Publication number
- JP6195850B2 JP6195850B2 JP2014558057A JP2014558057A JP6195850B2 JP 6195850 B2 JP6195850 B2 JP 6195850B2 JP 2014558057 A JP2014558057 A JP 2014558057A JP 2014558057 A JP2014558057 A JP 2014558057A JP 6195850 B2 JP6195850 B2 JP 6195850B2
- Authority
- JP
- Japan
- Prior art keywords
- signal
- absorption
- type
- ray
- diffraction grating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000004434 Calcinosis Diseases 0.000 title claims description 73
- 238000010521 absorption reaction Methods 0.000 claims description 58
- 238000000034 method Methods 0.000 claims description 37
- 230000002308 calcification Effects 0.000 claims description 25
- 238000003384 imaging method Methods 0.000 claims description 13
- LFEUVBZXUFMACD-UHFFFAOYSA-H lead(2+);trioxido(oxo)-$l^{5}-arsane Chemical compound [Pb+2].[Pb+2].[Pb+2].[O-][As]([O-])([O-])=O.[O-][As]([O-])([O-])=O LFEUVBZXUFMACD-UHFFFAOYSA-H 0.000 claims description 13
- 230000010363 phase shift Effects 0.000 claims description 11
- 238000012545 processing Methods 0.000 claims description 10
- 238000011156 evaluation Methods 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 6
- 230000035945 sensitivity Effects 0.000 claims description 6
- 239000013078 crystal Substances 0.000 claims description 5
- 238000000333 X-ray scattering Methods 0.000 claims description 3
- 238000002591 computed tomography Methods 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 238000007689 inspection Methods 0.000 claims description 2
- 238000005305 interferometry Methods 0.000 claims description 2
- 230000008447 perception Effects 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims description 2
- 238000009607 mammography Methods 0.000 description 13
- 210000000481 breast Anatomy 0.000 description 7
- 230000003902 lesion Effects 0.000 description 6
- 238000001069 Raman spectroscopy Methods 0.000 description 5
- 230000000877 morphologic effect Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 206010006187 Breast cancer Diseases 0.000 description 4
- 208000026310 Breast neoplasm Diseases 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 3
- 235000011941 Tilia x europaea Nutrition 0.000 description 3
- 239000004571 lime Substances 0.000 description 3
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 208000000265 Lobular Carcinoma Diseases 0.000 description 1
- 238000001237 Raman spectrum Methods 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 201000003714 breast lobular carcinoma Diseases 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- PBUBJNYXWIDFMU-UHFFFAOYSA-L calcium;butanedioate Chemical compound [Ca+2].[O-]C(=O)CCC([O-])=O PBUBJNYXWIDFMU-UHFFFAOYSA-L 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 206010073096 invasive lobular breast carcinoma Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000007447 staining method Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/502—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of breast, i.e. mammography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
- A61B6/4035—Arrangements for generating radiation specially adapted for radiation diagnosis the source being combined with a filter or grating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4291—Arrangements for detecting radiation specially adapted for radiation diagnosis the detector being combined with a grid or grating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/483—Diagnostic techniques involving scattered radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/484—Diagnostic techniques involving phase contrast X-ray imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
- A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
- A61B6/5217—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data extracting a diagnostic or physiological parameter from medical diagnostic data
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T11/00—2D [Two Dimensional] image generation
- G06T11/003—Reconstruction from projections, e.g. tomography
- G06T11/005—Specific pre-processing for tomographic reconstruction, e.g. calibration, source positioning, rebinning, scatter correction, retrospective gating
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/10—Segmentation; Edge detection
- G06T7/174—Segmentation; Edge detection involving the use of two or more images
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10072—Tomographic images
- G06T2207/10081—Computed x-ray tomography [CT]
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10116—X-ray image
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/20—Special algorithmic details
- G06T2207/20212—Image combination
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30068—Mammography; Breast
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- High Energy & Nuclear Physics (AREA)
- Optics & Photonics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- General Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- Quality & Reliability (AREA)
- Dentistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Physiology (AREA)
- Toxicology (AREA)
- Primary Health Care (AREA)
- Epidemiology (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Description
a)回折格子ベースの干渉法またはアナライザ結晶ベースの撮影法またはコーデッドアパーチャ撮影法に基づくX線検査等の、吸収信号および小角散乱信号を記録するための装置と、
b)少なくとも1対の微細石灰化の分析を行うように構成された信号処理手段と
を有し、
前記分析は、異なるタイプの微細石灰化は逆の吸収信号および小角散乱信号を有するという認識に基づく、すなわち、一方のタイプは他方のタイプよりも弱い吸収信号を出すが、当該他方のタイプよりも強い小角散乱信号を出し、またはその逆であるという認識に基づく
ことを特徴とする、非侵襲的分類システムにより解決される。
ACは吸収信号であり、かつ
SCは小角散乱信号であり、かつ
前記装置は、
a.X線源と、
b.G0,G1およびG2との名称の3つの回折格子、または、G1およびG2との名称の少なくとも2つの回折格子と、
c.検出感度が空間的変調される、複数の個別ピクセルを有する位置検出器と、
d.検出器の画像を記録するための手段と、
e.吸収優位ピクセルとして、または微分位相コントラスト優位ピクセルとして、またはX線散乱優位ピクセルとして各ピクセルごとに撮影対象の特性を識別するため、画像列の各ピクセルの強度を評価するように構成された評価モジュールと
を有し、
f.0からπまで、または0から2πまで、連続的または離散的に前記標本を回転させるか、または当該標本に対して前記装置および前記線源を相対回転させながら、前記画像列を収集する。
β=(λ/4π)μ
により、X線の線形減衰係数μに関連づけられる。同式中、λはX線の波長である。
と
とを直接得ることができる。これら2つの信号もまた、2つの各微細石灰化タイプでは逆になるので、同じルールが成り立つ。
Claims (9)
- 人体組織内の微細石灰化の吸収信号と小角散乱信号とを併用した、当該微細石灰化の複数の異なるタイプの非侵襲的分類システムであって、
a)回折格子ベースの干渉法またはアナライザ結晶ベースの撮影法またはコーデッドアパーチャ撮影法に基づくX線検査等の、吸収信号および小角散乱信号を記録するための装置と、
b)少なくとも1対の微細石灰化の分析を行うように構成された信号処理手段と
を有し、
前記分析は、異なるタイプの微細石灰化は逆の吸収信号および小角散乱信号を有するという認識に基づく、すなわち、一方のタイプは他方のタイプよりも弱い吸収信号を出すが、当該他方のタイプよりも強い小角散乱信号を出し、またはその逆であるという認識に基づく
ことを特徴とする、非侵襲的分類システム。 - 微細石灰化の対に信号対(t1,t2)を対応付け、
ここで、t1,t2⊂{+,−}であり、t1およびt2はそれぞれ、前記吸収信号の相対信号強度および前記小角散乱信号の相対信号強度を表し、「+」はその信号の方が強いことを意味し、「−」はその信号の方が弱いことを意味し、
前記信号処理手段に含まれる評価モジュールが、2つの前記信号対が(+,−)および(−,+)の組合せを成すか否かを判別することにより、当該2つの各信号対がそれぞれ異なる微細石灰化タイプに分類されるか否かを判定し、符号が(−,+)である微細石灰化がタイプIの微細石灰化である蓋然性が高く、(+,−)は、タイプ II の微細石灰化である蓋然性の方が高いと認められることを示唆する、
請求項1記載の非侵襲的分類システム。 - 信号データが(マルチモダリティ)コンピュータ断層撮影により求められる場合、前記データ処理手段は吸収情報および散乱情報の投影像から当該吸収情報および小角散乱情報の断層画像を再構成し、前記減衰係数μおよび前記一般化された散乱パラメータSを直接求め、さらに、前記微細石灰化の2つのタイプでは前記2つの信号は逆である、
請求項3記載の非侵襲的分類システム。 - 標本から定量的X線像を得るために前記吸収信号および小角散乱信号をX線用の装置から、とりわけ硬X線用の装置から受け取り、
前記装置は、
a.X線源と、
b.G0,G1およびG2との名称の3つの回折格子、または、G1およびG2との名称の少なくとも2つの回折格子と、
c.検出感度が空間的変調される、複数の個別のピクセルを有する位置感度検出器と、
d.前記検出器の画像を記録するための手段と、
e.吸収優位ピクセルとして、または微分位相コントラスト優位ピクセルとして、またはX線散乱優位ピクセルとして各ピクセルごとに撮影対象の特性を識別するため、複数の前記画像の各ピクセルの強度を評価するように構成された評価モジュールと
を有し、
f.0からπまで、または0から2πまで、連続的または離散的に前記標本を回転させるか、または当該標本に対して前記装置および前記線源を回転させながら、複数の前記画像を収集する、
請求項1から3までのいずれか1項記載の非侵襲的分類システム。 - 前記非侵襲的分類システムは、いわゆる「近接場方式」または「タルボ方式」で動作する、
請求項5記載の非侵襲的分類システム。 - G1は、低吸収性の回折格子であるが相当量のX線位相シフトを生成する位相型回折格子、または、吸収型回折格子のいずれかである線状回折格子であり、
前記位相シフトは有利にはπまたはπの奇数倍であり、
G2は、G1の自己像の周期と等しい周期を有する、X線吸収コントラストが高い線状回折格子であり、
G2は前記検出器の前面の近傍に配置され、かつ、G2の線がG1の線と平行になるように配置されている、
請求項5または6記載の非侵襲的分類システム。 - いずれか1つの前記回折格子G0,G1またはG2を他の前記回折格子に対して相対的に移動させることにより位相ステッピングを行う、
請求項5から8までのいずれか1項記載の非侵襲的分類システム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12156853.9 | 2012-02-24 | ||
EP12156853 | 2012-02-24 | ||
PCT/EP2013/052451 WO2013124164A1 (en) | 2012-02-24 | 2013-02-07 | A system for non-invasively classification of different types of micro-calcifications in human tissue |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015507984A JP2015507984A (ja) | 2015-03-16 |
JP6195850B2 true JP6195850B2 (ja) | 2017-09-13 |
Family
ID=47716013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014558057A Expired - Fee Related JP6195850B2 (ja) | 2012-02-24 | 2013-02-07 | 人体組織の微小石灰化の複数の異なるタイプの非侵襲的分類システム |
Country Status (7)
Country | Link |
---|---|
US (1) | US9439615B2 (ja) |
EP (1) | EP2817781B1 (ja) |
JP (1) | JP6195850B2 (ja) |
CN (1) | CN104137149B (ja) |
AU (1) | AU2013224308B2 (ja) |
CA (1) | CA2865293C (ja) |
WO (1) | WO2013124164A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013184213A2 (en) * | 2012-05-14 | 2013-12-12 | The General Hospital Corporation | A distributed, field emission-based x-ray source for phase contrast imaging |
US9700275B2 (en) | 2013-05-10 | 2017-07-11 | Paul Scherrer Institut | Quantitative X-ray radiology using the absorption and scattering information |
WO2016177588A1 (en) * | 2015-05-06 | 2016-11-10 | Koninklijke Philips N.V. | Optimal energy weighting of dark field signal in differential phase contrast x-ray imaging |
CN104873214B (zh) * | 2015-05-22 | 2018-04-13 | 北京师范大学 | 早期乳腺癌的检测装置 |
WO2018191753A1 (en) * | 2017-04-15 | 2018-10-18 | Sigray, Inc. | Talbot x-ray microscope |
EP3494885A1 (en) | 2017-12-07 | 2019-06-12 | Koninklijke Philips N.V. | Apparatus for presentation of dark field x-ray image information |
CN113171116A (zh) * | 2021-01-18 | 2021-07-27 | 深圳市第二人民医院(深圳市转化医学研究院) | 一种用于检测软组织异物的多模态x射线成像设备及其方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6054712A (en) * | 1998-01-23 | 2000-04-25 | Quanta Vision, Inc. | Inspection equipment using small-angle topography in determining an object's internal structure and composition |
US5999639A (en) * | 1997-09-04 | 1999-12-07 | Qualia Computing, Inc. | Method and system for automated detection of clustered microcalcifications from digital mammograms |
CN1273516A (zh) | 1997-08-28 | 2000-11-15 | 特性计算公司 | 从数字乳房x射线照片中自动检测成簇的微钙化的方法和系统 |
JP4200104B2 (ja) * | 2003-01-31 | 2008-12-24 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置 |
GB0606891D0 (en) * | 2006-04-05 | 2006-05-17 | Council Cent Lab Res Councils | Raman Analysis Of Pharmaceutical Tablets |
CN101234026B (zh) * | 2008-03-07 | 2010-04-14 | 李立 | 一种乳腺病变定量化影像评价系统 |
US8152603B2 (en) | 2008-11-20 | 2012-04-10 | Illinois Tool Works Inc. | Slide holder for sample holder for grinder/polisher |
AU2010210169B2 (en) | 2009-02-05 | 2015-04-09 | Paul Scherrer Institut | Low dose single step grating based X-ray phase contrast imaging |
JP2011224329A (ja) * | 2010-03-30 | 2011-11-10 | Fujifilm Corp | 放射線撮影システム及び方法 |
EP2585817B1 (en) | 2010-06-28 | 2020-01-22 | Paul Scherrer Institut | A method for x-ray phase contrast and dark-field imaging using an arrangement of gratings in planar geometry |
WO2012128335A1 (ja) * | 2011-03-23 | 2012-09-27 | コニカミノルタエムジー株式会社 | 医用画像表示システム |
-
2013
- 2013-02-07 CA CA2865293A patent/CA2865293C/en active Active
- 2013-02-07 CN CN201380010632.XA patent/CN104137149B/zh not_active Expired - Fee Related
- 2013-02-07 WO PCT/EP2013/052451 patent/WO2013124164A1/en active Application Filing
- 2013-02-07 AU AU2013224308A patent/AU2013224308B2/en not_active Ceased
- 2013-02-07 JP JP2014558057A patent/JP6195850B2/ja not_active Expired - Fee Related
- 2013-02-07 US US14/380,817 patent/US9439615B2/en not_active Expired - Fee Related
- 2013-02-07 EP EP13704402.0A patent/EP2817781B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2817781A1 (en) | 2014-12-31 |
CA2865293A1 (en) | 2013-08-29 |
WO2013124164A1 (en) | 2013-08-29 |
EP2817781B1 (en) | 2017-07-19 |
CA2865293C (en) | 2020-10-27 |
AU2013224308B2 (en) | 2017-08-03 |
US20150030123A1 (en) | 2015-01-29 |
CN104137149A (zh) | 2014-11-05 |
US9439615B2 (en) | 2016-09-13 |
CN104137149B (zh) | 2017-03-01 |
JP2015507984A (ja) | 2015-03-16 |
AU2013224308A1 (en) | 2014-08-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6195850B2 (ja) | 人体組織の微小石灰化の複数の異なるタイプの非侵襲的分類システム | |
Iranmakani et al. | A review of various modalities in breast imaging: technical aspects and clinical outcomes | |
Choe et al. | Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography | |
Schulz et al. | High-resolution tomographic imaging of a human cerebellum: comparison of absorption and grating-based phase contrast | |
Zhou et al. | Development of phase-contrast X-ray imaging techniques and potential medical applications | |
Asao et al. | Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images | |
Cerussi et al. | Frequent optical imaging during breast cancer neoadjuvant chemotherapy reveals dynamic tumor physiology in an individual patient | |
Leproux et al. | Assessing tumor contrast in radiographically dense breast tissue using diffuse optical spectroscopic imaging (DOSI) | |
Turchin | Methods of biomedical optical imaging: from subcellular structures to tissues and organs | |
van de Ven et al. | Diffuse optical tomography of the breast: initial validation in benign cysts | |
Ban et al. | Heterodyne frequency‐domain multispectral diffuse optical tomography of breast cancer in the parallel‐plane transmission geometry | |
Yang et al. | Quantitative analysis of breast tumours aided by three-dimensional photoacoustic/ultrasound functional imaging | |
Yamashita | Visible and infrared diaphanoscopy for medical diagnosis | |
Fournier et al. | Dynamic optical breast imaging: a novel technique to detect and characterize tumor vessels | |
Ding et al. | Optical coherence tomography for the early detection of colorectal dysplasia and cancer: validation in a murine model | |
Butler et al. | MARS pre-clinical imaging: the benefits of small pixels and good energy data | |
Vedantham et al. | Emerging breast imaging technologies on the horizon | |
Maffeis et al. | The SOLUS instrument: Optical characterization of the first hand-held probe for multimodal imaging (ultrasound and multi-wavelength time-resolved diffuse optical tomography) | |
Zhu et al. | Combined ultrasound and near infrared diffused light imaging in a test object | |
Ardeshirpour et al. | Optical tomography method that accounts for tilted chest wall in breast imaging | |
Ando et al. | Crystal-based X-ray Medical Imaging Using Synchrotron Radiation and Its Future Prospect | |
Uddin | Ultrasound Guided Diffuse Optical Tomography for Breast Cancer Diagnosis: Algorithm Development | |
Walker | Breast Cancer Imaging Using Light: Ancient, History and Current State | |
Vasudevan | The Role of Broadband Near Infrared Spectroscopy in Breast Cancer Diagnosis | |
Nandy | Assessment and Diagnosis of Human Ovarian and Colorectal Cancer using Optical and Photoacoustic Imaging |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160115 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20161212 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170110 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170210 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20170718 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170816 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6195850 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |