JP6185839B2 - Braf阻害薬とvegf阻害薬との組み合わせ - Google Patents

Braf阻害薬とvegf阻害薬との組み合わせ Download PDF

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Publication number
JP6185839B2
JP6185839B2 JP2013529184A JP2013529184A JP6185839B2 JP 6185839 B2 JP6185839 B2 JP 6185839B2 JP 2013529184 A JP2013529184 A JP 2013529184A JP 2013529184 A JP2013529184 A JP 2013529184A JP 6185839 B2 JP6185839 B2 JP 6185839B2
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Japan
Prior art keywords
cancer
compound
pharmaceutically acceptable
leukemia
cell
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Expired - Fee Related
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JP2013529184A
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English (en)
Japanese (ja)
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JP2013537228A (ja
JP2013537228A5 (OSRAM
Inventor
クマール,ラケシュ
Original Assignee
ノバルティス アーゲー
ノバルティス アーゲー
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Publication of JP2013537228A5 publication Critical patent/JP2013537228A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2013529184A 2010-09-14 2011-09-02 Braf阻害薬とvegf阻害薬との組み合わせ Expired - Fee Related JP6185839B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38251110P 2010-09-14 2010-09-14
US61/382,511 2010-09-14
PCT/US2011/050302 WO2012036919A2 (en) 2010-09-14 2011-09-02 Combination of braf and vegf inhibitors

Publications (3)

Publication Number Publication Date
JP2013537228A JP2013537228A (ja) 2013-09-30
JP2013537228A5 JP2013537228A5 (OSRAM) 2014-09-25
JP6185839B2 true JP6185839B2 (ja) 2017-08-23

Family

ID=45832170

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013529184A Expired - Fee Related JP6185839B2 (ja) 2010-09-14 2011-09-02 Braf阻害薬とvegf阻害薬との組み合わせ

Country Status (4)

Country Link
US (3) US20130172378A1 (OSRAM)
EP (1) EP2616057A4 (OSRAM)
JP (1) JP6185839B2 (OSRAM)
WO (1) WO2012036919A2 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2637184C (en) 2006-02-07 2016-08-16 Ticketmaster Methods and systems for reducing burst usage of a networked computer system
JP2015524825A (ja) * 2012-08-17 2015-08-27 キャンサー・セラピューティクス・シーアールシー・ピーティーワイ・リミテッド Vegfr3阻害剤
US9238644B2 (en) * 2012-08-17 2016-01-19 Cancer Therapeutics Crc Pty Limited VEGFR3 inhibitors
EP2925728A4 (en) * 2012-11-27 2016-11-02 Glaxosmithkline Llc COMBINATION
CN104540822B (zh) * 2013-07-08 2016-08-31 杭州普晒医药科技有限公司 达拉菲尼甲磺酸盐的晶型及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
ATE430742T1 (de) 2000-12-21 2009-05-15 Smithkline Beecham Corp Pyrimidinamine als angiogenesemodulatoren
WO2005105094A2 (en) * 2004-04-16 2005-11-10 Smithkline Beecham Corporation Cancer treatment method
JP2007537296A (ja) * 2004-05-14 2007-12-20 アボット・ラボラトリーズ 治療薬としてのキナーゼ阻害薬
EP2368566A1 (en) * 2006-07-13 2011-09-28 ZymoGenetics, Inc. Interleukin 21 and tyrosine kinase inhibitor combination therapy
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds

Also Published As

Publication number Publication date
EP2616057A2 (en) 2013-07-24
JP2013537228A (ja) 2013-09-30
EP2616057A4 (en) 2014-03-12
WO2012036919A3 (en) 2012-08-16
US20160243118A1 (en) 2016-08-25
US20130172378A1 (en) 2013-07-04
WO2012036919A2 (en) 2012-03-22
US20150335645A1 (en) 2015-11-26

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