JP6182246B2 - Crying device for cryopreservation bag - Google Patents

Crying device for cryopreservation bag Download PDF

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Publication number
JP6182246B2
JP6182246B2 JP2016143194A JP2016143194A JP6182246B2 JP 6182246 B2 JP6182246 B2 JP 6182246B2 JP 2016143194 A JP2016143194 A JP 2016143194A JP 2016143194 A JP2016143194 A JP 2016143194A JP 6182246 B2 JP6182246 B2 JP 6182246B2
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Japan
Prior art keywords
bag
fixed
block
sealing
clamping block
Prior art date
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Active
Application number
JP2016143194A
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Japanese (ja)
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JP2017001749A (en
Inventor
晏夫 黒▲崎▼
晏夫 黒▲崎▼
克彦 上田
克彦 上田
公俊 佐藤
公俊 佐藤
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UEDA SEITAI CO.,LTD.
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UEDA SEITAI CO.,LTD.
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Priority to JP2016143194A priority Critical patent/JP6182246B2/en
Publication of JP2017001749A publication Critical patent/JP2017001749A/en
Application granted granted Critical
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/244—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being non-straight, e.g. forming non-closed contours
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/14—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using wave energy, i.e. electromagnetic radiation, or particle radiation
    • B29C65/16—Laser beams
    • B29C65/1603—Laser beams characterised by the type of electromagnetic radiation
    • B29C65/1612—Infrared [IR] radiation, e.g. by infrared lasers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/14—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using wave energy, i.e. electromagnetic radiation, or particle radiation
    • B29C65/16—Laser beams
    • B29C65/1629—Laser beams characterised by the way of heating the interface
    • B29C65/1635—Laser beams characterised by the way of heating the interface at least passing through one of the parts to be joined, i.e. laser transmission welding
    • B29C65/1638—Laser beams characterised by the way of heating the interface at least passing through one of the parts to be joined, i.e. laser transmission welding focusing the laser beam on the interface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/14—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using wave energy, i.e. electromagnetic radiation, or particle radiation
    • B29C65/16—Laser beams
    • B29C65/1629—Laser beams characterised by the way of heating the interface
    • B29C65/1654—Laser beams characterised by the way of heating the interface scanning at least one of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/78—Means for handling the parts to be joined, e.g. for making containers or hollow articles, e.g. means for handling sheets, plates, web-like materials, tubular articles, hollow articles or elements to be joined therewith; Means for discharging the joined articles from the joining apparatus
    • B29C65/7841—Holding or clamping means for handling purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/23—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being multiple and parallel or being in the form of tessellations
    • B29C66/232—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being multiple and parallel or being in the form of tessellations said joint lines being multiple and parallel, i.e. the joint being formed by several parallel joint lines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/40—General aspects of joining substantially flat articles, e.g. plates, sheets or web-like materials; Making flat seams in tubular or hollow articles; Joining single elements to substantially flat surfaces
    • B29C66/41—Joining substantially flat articles ; Making flat seams in tubular or hollow articles
    • B29C66/43—Joining a relatively small portion of the surface of said articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/40—General aspects of joining substantially flat articles, e.g. plates, sheets or web-like materials; Making flat seams in tubular or hollow articles; Joining single elements to substantially flat surfaces
    • B29C66/41—Joining substantially flat articles ; Making flat seams in tubular or hollow articles
    • B29C66/43—Joining a relatively small portion of the surface of said articles
    • B29C66/431—Joining the articles to themselves
    • B29C66/4312—Joining the articles to themselves for making flat seams in tubular or hollow articles, e.g. transversal seams
    • B29C66/43121—Closing the ends of tubular or hollow single articles, e.g. closing the ends of bags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/733—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the optical properties of the material of the parts to be joined, e.g. fluorescence, phosphorescence
    • B29C66/7336—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the optical properties of the material of the parts to be joined, e.g. fluorescence, phosphorescence at least one of the parts to be joined being opaque, transparent or translucent to visible light
    • B29C66/73365—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the optical properties of the material of the parts to be joined, e.g. fluorescence, phosphorescence at least one of the parts to be joined being opaque, transparent or translucent to visible light at least one of the parts to be joined being transparent or translucent to visible light
    • B29C66/73366—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the optical properties of the material of the parts to be joined, e.g. fluorescence, phosphorescence at least one of the parts to be joined being opaque, transparent or translucent to visible light at least one of the parts to be joined being transparent or translucent to visible light both parts to be joined being transparent or translucent to visible light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/81—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
    • B29C66/812—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the composition, by the structure, by the intensive physical properties or by the optical properties of the material constituting the pressing elements, e.g. constituting the welding jaws or clamps
    • B29C66/8126—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the composition, by the structure, by the intensive physical properties or by the optical properties of the material constituting the pressing elements, e.g. constituting the welding jaws or clamps characterised by the intensive physical properties or by the optical properties of the material constituting the pressing elements, e.g. constituting the welding jaws or clamps
    • B29C66/81261—Thermal properties, e.g. thermal conductivity, thermal expansion coefficient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
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    • B29C66/812—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the composition, by the structure, by the intensive physical properties or by the optical properties of the material constituting the pressing elements, e.g. constituting the welding jaws or clamps
    • B29C66/8126—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the composition, by the structure, by the intensive physical properties or by the optical properties of the material constituting the pressing elements, e.g. constituting the welding jaws or clamps characterised by the intensive physical properties or by the optical properties of the material constituting the pressing elements, e.g. constituting the welding jaws or clamps
    • B29C66/81266—Optical properties, e.g. transparency, reflectivity
    • B29C66/81267—Transparent to electromagnetic radiation, e.g. to visible light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
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    • B29C66/818—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps
    • B29C66/8181—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps characterised by the cooling constructional aspects
    • B29C66/81811—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps characterised by the cooling constructional aspects of the welding jaws
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
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    • B29C66/80—General aspects of machine operations or constructions and parts thereof
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    • B29C66/818—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps
    • B29C66/8183—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps characterised by the thermal conducting constructional aspects
    • B29C66/81831—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the cooling constructional aspects, or by the thermal or electrical insulating or conducting constructional aspects of the welding jaws or of the clamps ; comprising means for compensating for the thermal expansion of the welding jaws or of the clamps characterised by the thermal conducting constructional aspects of the welding jaws
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
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    • B65B51/00—Devices for, or methods of, sealing or securing package folds or closures; Devices for gathering or twisting wrappers, or necks of bags
    • B65B51/10—Applying or generating heat or pressure or combinations thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
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    • B65B51/00—Devices for, or methods of, sealing or securing package folds or closures; Devices for gathering or twisting wrappers, or necks of bags
    • B65B51/10—Applying or generating heat or pressure or combinations thereof
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/90—Measuring or controlling the joining process
    • B29C66/96—Measuring or controlling the joining process characterised by the method for implementing the controlling of the joining process
    • B29C66/967—Measuring or controlling the joining process characterised by the method for implementing the controlling of the joining process involving special data inputs or special data outputs, e.g. for monitoring purposes
    • B29C66/9672—Measuring or controlling the joining process characterised by the method for implementing the controlling of the joining process involving special data inputs or special data outputs, e.g. for monitoring purposes involving special data inputs, e.g. involving barcodes, RFID tags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/712—Containers; Packaging elements or accessories, Packages
    • B29L2031/7148—Blood bags, medical bags

Description

本発明は人、動物、植物などの生体組織を凍結保存する際に使用する凍結保存用バッグの開口部分をシールし密封する封口装置に関する。凍結保存用バッグは、２枚重ねにしたフッ素系樹脂シートを赤外線レーザービームで溶着して袋状の容器として形成する。   The present invention relates to a sealing device that seals and seals an opening portion of a cryopreservation bag used when cryopreserving a living tissue such as a human being, an animal, or a plant. The cryopreservation bag is formed as a bag-like container by welding two laminated fluororesin sheets with an infrared laser beam.

この種の凍結保存用バッグは、例えば特許文献１に開示されている。そこでは、２枚重ねにした熱可塑性樹脂フィルムを、支持体と赤外線透過固体放熱材（以下、単に放熱材と称す）とで挟み込んで加圧し、放熱材の側から赤外レーザービームを両フィルムに照射して溶着ビードを形成し、袋状の凍結保存用バッグを形成している。   This type of cryopreservation bag is disclosed in Patent Document 1, for example. In this case, two laminated thermoplastic resin films are sandwiched between a support and an infrared transmitting solid heat dissipating material (hereinafter simply referred to as a heat dissipating material) and pressed, and an infrared laser beam is applied to both films from the heat dissipating material side. To form a weld bead to form a bag-like cryopreservation bag.

本発明の封口装置に関して、凍結保存用容器の開口部を熱溶着により封止することが特許文献２に開示されている。そこでは、生体試料を収容するプラスチック製の容器本体に、開口部と開封部とが一体に設けてあり、生体試料を容器本体の収容したのち開口部をシーラーで熱溶着して封止している。   Regarding the sealing device of the present invention, Patent Document 2 discloses that the opening of a cryopreservation container is sealed by thermal welding. There, an opening and an opening are integrally provided in a plastic container main body that contains a biological sample. After the biological sample is accommodated in the container main body, the opening is thermally sealed with a sealer and sealed. Yes.

国際公開第２００３−０３９８４３号（１１ページ実施例１、図３）International Publication No. 2003-039843 (page 11, Example 1, FIG. 3) 特開２００７−３０２５６７号公報（段落番号００３５、図１）Japanese Patent Laying-Open No. 2007-302567 (paragraph number 0035, FIG. 1)

特許文献２の凍結保存用バッグは、例えばポリエチレンテレフタレートで形成してあるので、インパルス式の市販のシーラーでも十分に封口処理を行える。しかし、フッ素系樹脂で形成した凍結保存用バッグは、より高温でシール加工を行う必要があるため、市販のシーラーで出入口を熱溶着して、ばらつきなく高度の封止機能を発揮させるのは難しい。高度の封止機能を発揮できない凍結保存用バッグは、液体窒素がバッグ内に浸入するおそれがあり、そのことを知らないまま凍結保存用バッグを液体窒素容器から取り出した場合に、液体窒素が急激に膨張して凍結保存用バッグが破損し、内容物が飛散するおそれがある。凍結保存用バッグは病院などの臨床現場で使用されることが多く、主なユーザーである医師や医療技術者にとっては、凍結保存用バッグの封口処理を安全にしかも的確に行え、しかも高度の封止機能を発揮できることが望まれている。   Since the cryopreservation bag of Patent Document 2 is made of, for example, polyethylene terephthalate, even an impulse-type commercially available sealer can be sufficiently sealed. However, since the cryopreservation bag made of fluororesin needs to be sealed at a higher temperature, it is difficult to thermally weld the entrance and exit with a commercially available sealer to exhibit a high degree of sealing function without variation. . In a cryopreservation bag that cannot exhibit a high degree of sealing function, there is a risk that liquid nitrogen may enter the bag, and if the cryopreservation bag is taken out of the liquid nitrogen container without knowing that, the liquid nitrogen suddenly increases. If the bag is frozen, the cryopreservation bag may be damaged and the contents may be scattered. Cryopreservation bags are often used in clinical settings such as hospitals, and the main users, doctors and medical technicians, can safely and accurately seal the cryopreservation bags, and have advanced sealing. It is desired to be able to demonstrate the stopping function.

本発明の目的は、凍結保存用バッグの封口処理を簡便に自動的に行って、封口処理を安全にしかも的確に行える凍結保存用バッグの封口装置を提供することにある。   It is an object of the present invention to provide a cryopreservation bag sealing device that can perform sealing processing of a cryopreservation bag simply and automatically, and can perform the sealing processing safely and accurately.

本発明に係る凍結保存用バッグの封口装置は、凍結保存用バッグの封口部５５を挟持固定するバッグクランプ装置５６と、バッグクランプ装置５６で挟持固定した封口部５５に向かって赤外線レーザービームを照射するレーザー装置５７と、上記の各部材５６・５７を支持するフレーム５９を備えている。バッグクランプ装置５６は、フレーム５９に支持される固定挟持ブロック６７と、固定挟持ブロック６７に設けたガイド軸６８で固定挟持ブロック６７に対して接離自在に支持される可動挟持ブロック６９と、可動挟持ブロック６９を固定挟持ブロック６７に対して接離操作するクランプアクチュエータ７０とを含む。レーザー装置５７は、レーザー発振器１０４と、レーザー発振器１０４から照射された赤外線レーザービームを、凍結保存用バッグの封口部５５に向かって集光する集光レンズ１０７を含む。固定挟持ブロック６７は、赤外線レーザービーム用の照射窓７２が開口してあるブロックベース７３と、赤外線透過作用と熱伝導作用に富む固体材料で構成される放熱体７４と、ブロックベース７３に装着されて放熱体７４を前記照射窓７２に臨む状態で支持する放熱体ホルダー７５とを備えている。固定挟持ブロック６７と可動挟持ブロック６９とで凍結保存用バッグの封口部５５を挟持固定した状態で、赤外線レーザービームを封口部５５に照射して、出入口３を横断する状態のシールビード１２５を封口部５５に形成する。 The sealing device for a cryopreservation bag according to the present invention irradiates an infrared laser beam toward a bag clamping device 56 that sandwiches and fixes the sealing portion 55 of the cryopreservation bag, and a sealing portion 55 that is sandwiched and fixed by the bag clamping device 56. a laser device 57 which includes a frame 59 for supporting the respective members 56, 5 7 above follow. Bag clamp device 56 includes a fixed clamping block 67 which is supported lifting the frame 59, the movable clamping block 69 which is separable rotatably supported with respect to the fixed clamping blocks 67 in the guide shaft 68 provided in the fixed clamping blocks 67, And a clamp actuator 70 for moving the movable clamping block 69 to and from the fixed clamping block 67. The laser device 57 includes a laser oscillator 104 and a condensing lens 107 that condenses the infrared laser beam emitted from the laser oscillator 104 toward the sealing portion 55 of the cryopreservation bag. The fixed clamping block 67 is mounted on the block base 73 having an infrared laser beam irradiation window 72 opened, a heat radiator 74 made of a solid material rich in infrared transmission and heat conduction, and the block base 73. And a radiator holder 75 for supporting the radiator 74 in a state of facing the irradiation window 72. In a state where the sealing portion 55 of the cryopreservation bag were sandwiched and fixed between the fixed clamping block 67 and the movable clamping block 69, by irradiating the infrared laser beam to the sealing portion 55, the sealing bead 125 of the state across the doorway 3 The sealing portion 55 is formed.

可動挟持ブロック６９は、ガイド軸６８で前後に往復スライド自在に支持される左右一対のスライダー７９と、両スライダー７９で固定支持される板状の可動ベース８０と、可動ベース８０の前面の左右に固定した左右一対のブロック支持軸８１で支持する。ガイド軸６８に固定したインナーベース８４に、可動ベース８０とブロック支持軸８１を介して可動挟持ブロック６９を前後操作するクランプアクチュエータ７０を設ける。凍結保存用バッグの封口部５５を固定挟持ブロック６７の放熱体７４の外面にあてがった状態で、可動挟持ブロック６９をクランプアクチュエータ７０で操作して、固定および可動の両挟持ブロック６７・６９で封口部５５をクランプ固定する。   The movable clamping block 69 includes a pair of left and right sliders 79 supported by a guide shaft 68 so as to be slidable back and forth, a plate-like movable base 80 fixedly supported by both sliders 79, and left and right of the front surface of the movable base 80. It is supported by a pair of fixed left and right block support shafts 81. The inner base 84 fixed to the guide shaft 68 is provided with a clamp actuator 70 for operating the movable clamping block 69 back and forth via the movable base 80 and the block support shaft 81. With the sealing portion 55 of the cryopreservation bag placed on the outer surface of the heat radiating body 74 of the fixed holding block 67, the movable holding block 69 is operated by the clamp actuator 70, and the fixed and movable holding blocks 67 and 69 are used for sealing. The part 55 is clamped and fixed.

可動挟持ブロック６９は、ブロック支持軸８１に対して第１装着具８３を介して着脱可能に装着する。放熱体ホルダー７５は、ブロックベース７３に対して第２装着具７７を介して着脱可能に装着する。可動挟持ブロック６９および放熱体ホルダー７５を、ブロック支持軸８１およびブロックベース７３から取外して滅菌処理する。   The movable clamping block 69 is detachably mounted on the block support shaft 81 via the first mounting tool 83. The radiator holder 75 is detachably attached to the block base 73 via the second attachment tool 77. The movable clamping block 69 and the radiator holder 75 are removed from the block support shaft 81 and the block base 73 and sterilized.

フレーム５９の内部に集光レンズ１０７の焦点位置を調整する焦点調整構造を設ける。焦点調整構造は、フレーム５９に固定したインナーフレーム９２で支持されるレンズベース１０８と、レンズベース１０８に固定したレンズガイド１０９と、レンズガイド１０９で前後スライド自在に支持される前後スライダー１１０と、前後スライダー１１０に固定されて集光レンズ１０７を支持するレンズホルダー１１１と、レンズホルダー１１１を前後操作する焦点調整アクチュエータ１１２を備えている。バッグクランプ装置５６で挟持固定された封口部５５の厚みに応じて、集光レンズ１０７の焦点位置を調整する。 A focus adjustment structure for adjusting the focal position of the condenser lens 107 is provided inside the frame 59. The focus adjustment structure includes a lens base 108 supported by an inner frame 92 fixed to a frame 59 , a lens guide 109 fixed to the lens base 108, a front and rear slider 110 supported slidably forward and backward by the lens guide 109, and a front and rear A lens holder 111 that is fixed to the slider 110 and supports the condenser lens 107, and a focus adjustment actuator 112 that operates the lens holder 111 back and forth are provided. The focal position of the condensing lens 107 is adjusted according to the thickness of the sealing portion 55 held and fixed by the bag clamp device 56.

フレーム５９の外面を、レーザー装置５７から漏洩する赤外線レーザーによる被ばくを防ぐ防護壁１１７で覆う。バッグクランプ装置５６の外面に、赤外線レーザーによる被ばくを防ぐ防護カバー１１８を開閉可能に設ける。   The outer surface of the frame 59 is covered with a protective wall 117 that prevents exposure by an infrared laser leaking from the laser device 57. A protective cover 118 that prevents exposure by an infrared laser is provided on the outer surface of the bag clamp device 56 so as to be openable and closable.

本発明に係る凍結保存用バッグの封口装置では、バッグクランプ装置５６と、レーザー装置５７などで封口装置を構成した。また、バッグクランプ装置５６は、固定挟持ブロック６７と、可動挟持ブロック６９と、可動挟持ブロック６９を接離操作するクランプアクチュエータ７０などで構成し、同アクチュエータ７０を作動させることにより、凍結保存用バッグの封口部５５を先の両挟持ブロック６７・６９で挟持固定できるようにした。さらに、ブロックベース７３と、放熱体７４および放熱体ホルダー７５などで固定挟持ブロック６７を構成して、赤外線レーザービームを、放熱体７４を介して封口部５５へ照射して、シールビード１２５を形成できるようにした。 With a sealing device cryopreservation bag according to the present invention, a bag clamp apparatus 56, to constitute a sealing device etc. laser device 5 7. The bag clamping device 56 includes a fixed clamping block 67, a movable clamping block 69, and a clamp actuator 70 for operating the movable clamping block 69. The bag 70 for cryopreservation is operated by operating the actuator 70. The sealing portion 55 can be clamped and fixed by the both clamping blocks 67 and 69. Furthermore, the block base 73, constitute a radiator body 74 and the heat radiating body holder 75 fixed clamping blocks 67 or the like, the infrared laser beam is irradiated to the sealing portion 55 through the heat radiator 74, the sealing bead 125 I was able to form.

上記の封口装置によれば、可動挟持ブロック６９をクランプアクチュエータ７０で移動操作して、封口部５５をクランプしたのち、レーザー装置５７を作動させることにより、フッ素系樹脂Ｓ１・Ｓ２を素材とする凍結保存用バッグの出入口３を簡便かつ自動的に封止することができる。凍結保存用バッグの封口部５５の封止作業は、医師や医療技術者によって行われるが、封口部５５をバッグクランプ装置５６でクランプしたのちは、一連の溶着作業が自動的に行われるので、凍結保存用バッグの封口処理を安全にしかも的確に行うことができる。さらに、封口処理は常に一定の条件下で自動的に行われるので溶着結果にばらつきがなく、従って高度の封止機能を安定した状態で発揮できる封口処理を、誰もが手軽に行える凍結保存用バッグの封口装置を提供できる。とくに、高温でシール加工を行う必要があるフッ素系樹脂で形成した凍結保存用バッグであっても、その封口処理を的確に行える。 According to the sealing device, and the moving operation of the movable clamping block 69 with a clamp actuator 70, after clamping the sealing portion 55, by operating the record Za device 57, a fluorine-based resin S1 · S2 and materials The entrance / exit 3 of the cryopreservation bag can be easily and automatically sealed. Although the sealing operation of the sealing portion 55 of the cryopreservation bag is performed by a doctor or a medical technician, since a series of welding operations are automatically performed after the sealing portion 55 is clamped by the bag clamp device 56, The sealing process of the cryopreservation bag can be performed safely and accurately. In addition, since the sealing process is always performed automatically under certain conditions, there is no variation in the welding results, and therefore, anyone can easily perform a sealing process that can exhibit a high level of sealing function in a stable state for cryopreservation. A bag sealing device can be provided. In particular, even a cryopreservation bag formed of a fluororesin that needs to be sealed at a high temperature can be properly sealed.

一対のスライダー７９と、可動ベース８０と、可動ベース８０に固定した一対のブロック支持軸８１で、可動挟持ブロック６９を固定挟持ブロック６７のガイド軸６８に対して前後スライド自在に支持すると、可動挟持ブロック６９を固定挟持ブロック６７に対して円滑に前後移動でき、しかも両挟持ブロック６７・６９の挟持面の平行度を高度化できる。また、ガイド軸６８に固定したインナーベース８４にクランプアクチュエータ７０を設けると、より簡単な構造のクランプアクチュエータ７０で可動挟持ブロック６９を前後操作して、固定および可動の両挟持ブロック６７・６９で封口部５５を確実にクランプ固定できる。   When the movable sandwiching block 69 is supported by the pair of sliders 79, the movable base 80, and the pair of block support shafts 81 fixed to the movable base 80 so as to be slidable back and forth with respect to the guide shaft 68 of the fixed sandwiching block 67, the movable sandwiching is performed. The block 69 can be smoothly moved back and forth with respect to the fixed clamping block 67, and the parallelism of the clamping surfaces of the both clamping blocks 67 and 69 can be enhanced. Further, when the clamp actuator 70 is provided on the inner base 84 fixed to the guide shaft 68, the movable clamping block 69 is operated back and forth with the clamp actuator 70 having a simpler structure, and sealing is performed with both the fixed and movable clamping blocks 67 and 69. The portion 55 can be securely clamped.

可動挟持ブロック６９は、ブロック支持軸８１に対して第１装着具８３を介して着脱可能に装着した。また、放熱体ホルダー７５は、ブロックベース７３に対して第２装着具７７を介して着脱可能に装着した。こうした封口装置によれば、必要に応じて可動挟持ブロック６９および放熱体ホルダー７５を、ブロック支持軸８１およびブロックベース７３から取外して、生体組織が付着しているかもしれない可動挟持ブロック６９および放熱体ホルダー７５を滅菌処理できる。従って、可動挟持ブロック６９、放熱体７４、放熱体ホルダー７５の衛生管理を容易化して、凍結保存用バッグの封口部５５の口処理を衛生的に安全な状態で行うことができる。   The movable clamping block 69 was detachably mounted on the block support shaft 81 via the first mounting tool 83. The radiator holder 75 is detachably attached to the block base 73 via the second attachment tool 77. According to such a sealing device, the movable clamping block 69 and the radiator holder 75 are removed from the block support shaft 81 and the block base 73 as necessary, and the movable clamping block 69 and the heat radiation to which the living tissue may adhere. The body holder 75 can be sterilized. Therefore, the hygienic management of the movable holding block 69, the radiator 74, and the radiator holder 75 can be facilitated, and the mouth treatment of the sealing portion 55 of the cryopreservation bag can be performed in a sanitary and safe state.

集光レンズ１０７の焦点位置を調整する焦点調整構造を設けると、焦点調整アクチュエータ１１２を作動させるだけで、集光レンズ１０７の焦点位置を簡便に調整することができる。従って、凍結保存用バッグを形成するフッ素系樹脂シートＳ１・Ｓ２の材質の違いや、厚みの違いに応じて集光レンズ１０７の焦点位置を調整して、封口部５５を最適の溶着条件で溶着することができる。   When a focus adjustment structure that adjusts the focal position of the condenser lens 107 is provided, the focal position of the condenser lens 107 can be easily adjusted simply by operating the focus adjustment actuator 112. Therefore, the focal position of the condensing lens 107 is adjusted according to the difference in material and thickness of the fluororesin sheets S1 and S2 forming the cryopreservation bag, and the sealing portion 55 is welded under optimum welding conditions. can do.

フレーム５９の外面を防護壁１１７で覆い、さらに、バッグクランプ装置５６の外面に開閉可能な防護カバー１１８を設けると、封口部５５を溶着する際に、ユーザーがレーザー装置５７から漏洩する赤外線レーザーに暴露されて被ばくするのを防止できるので、封口部５５の封止処理をさらに安全に行うことができる。   When the outer surface of the frame 59 is covered with a protective wall 117 and a protective cover 118 that can be opened and closed is provided on the outer surface of the bag clamp device 56, the infrared laser that leaks from the laser device 57 to the user when the sealing portion 55 is welded is used. Since it can prevent exposure and exposure, the sealing process of the sealing part 55 can be performed further safely.

本発明に係る凍結保存用バッグの封口装置の要部の縦断側面図である。It is a vertical side view of the principal part of the sealing device of the cryopreservation bag according to the present invention. 本発明に係る封口装置の概略構造を示す側面図である。It is a side view which shows schematic structure of the sealing apparatus which concerns on this invention. 本発明に係る封口装置の正面図である。It is a front view of the sealing apparatus which concerns on this invention. 図１におけるＡ−Ａ線断面図である。It is the sectional view on the AA line in FIG. バッグクランプ装置の分解斜視図である。It is a disassembled perspective view of a bag clamp apparatus. バッグクランプ装置に対する封口部の装着要領を示す縦断側面図である。It is a vertical side view which shows the attachment point of the sealing part with respect to a bag clamp apparatus. 封口部がクランプされた状態を示す縦断側面図である。It is a vertical side view which shows the state by which the sealing part was clamped. バッグクランプ装置に対する封口部の装着要領を示す正面図である。It is a front view which shows the attachment point of the sealing part with respect to a bag clamp apparatus. シールビードの形成例を示す正面図である。It is a front view which shows the example of formation of a seal bead. 本発明に係る凍結保存用バッグの製造装置の縦断側面図である。It is a vertical side view of the manufacturing apparatus of the cryopreservation bag according to the present invention. 凍結保存用バッグの製造装置の概略正面図である。It is a schematic front view of the manufacturing apparatus of the cryopreservation bag. 凍結保存用バッグの製造装置の平面図である。It is a top view of the manufacturing apparatus of the bag for cryopreservation. 操作構造の移動を示す側面図である。It is a side view which shows the movement of an operation structure. 溶着ビードの形成状況を示す断面図である。It is sectional drawing which shows the formation condition of a welding bead. 凍結保存用バッグの変形例を示す正面図である。It is a front view which shows the modification of the bag for cryopreservation. 図１５に係る凍結保存用バッグの封止構造を示す正面図である。It is a front view which shows the sealing structure of the bag for cryopreservation which concerns on FIG.

図１ないし図１４は、本発明に係る凍結保存用バッグの封口装置および関連装置等の実施例を示す。なお、本発明における前後、左右、上下とは、図２および図３に示す交差矢印と、各矢印の近傍に表記した前後、左右、上下の表示に従う。本発明に係る封口装置においては、例えば図８に示す構造の凍結保存用バッグを封口処理するが、封口装置の説明を行う前に、凍結保存用バッグの構造と、その製造装置について簡単に説明しておく。   1 to 14 show an embodiment of a sealing device for a cryopreservation bag and related devices according to the present invention. In the present invention, “front / rear”, “left / right”, and “up / down” follow the cross arrows shown in FIGS. 2 and 3 and the front / rear, left / right, upper / lower indications shown in the vicinity of each arrow. In the sealing device according to the present invention, for example, the cryopreservation bag having the structure shown in FIG. 8 is sealed. Before describing the sealing device, the structure of the cryopreservation bag and the manufacturing apparatus thereof will be briefly described. Keep it.

図８において、凍結保存用バッグは、２枚重ねにしたフッ素系樹脂シートＳ１・Ｓ２に赤外線レーザービームを照射して、前記両シートＳ１・Ｓ２の界面に一筆書き状の外郭線ビード１を形成し、外郭線ビード１で囲まれた両シートＳ１・Ｓ２の間に生体組織を収容する収容部２と、収容部２に連続する出入口３を形成してなる。収容部２を区画する外郭線ビード１は、上下一対の平行な上ビード部４および下ビード部５と、左右一対の平行な左ビード部６および右ビード部７と、各ビード部４〜７の隣接隅部に形成される４個の隅ビード部８とからなり、これにより収容部２は４隅が角落としされた縦長四角形状に形成してある。出入口３は上ビード部４の左右中央に形成してある。隅ビード部８を設けることにより、収容部２に直角の内隅が形成されるのを解消して、収容部２に収容した生体組織を余すところなく取出すことができる。   In FIG. 8, the cryopreservation bag irradiates two layers of fluororesin sheets S1 and S2 with an infrared laser beam to form a one-stroke outline outer bead 1 at the interface between the sheets S1 and S2. In addition, the storage unit 2 that stores the living tissue and the entrance / exit 3 that is continuous to the storage unit 2 are formed between the sheets S1 and S2 surrounded by the outer bead 1. The outer bead 1 that divides the housing portion 2 includes a pair of upper and lower parallel bead portions 4 and 5, a pair of left and right parallel bead portions 6 and 7, and bead portions 4 to 7. The four corner bead portions 8 are formed at the adjacent corner portions of the first and second corner bead portions 8, so that the accommodating portion 2 is formed in a vertically long rectangular shape with four corners dropped. The entrance / exit 3 is formed at the left and right center of the upper bead portion 4. By providing the corner bead portion 8, it is possible to eliminate the formation of a right-angle inner corner in the housing portion 2, and to take out the living tissue housed in the housing portion 2 without any excess.

フッ素系樹脂シートＳ１・Ｓ２は、完全フッ素化樹脂と、部分フッ素化樹脂と、フッ素化樹脂共重合体のいずれか一つを形成素材にして、赤外線レーザーの透過を許す透明シートとして形成してある。具体的な形成素材としては、ポリテトラフルオロエチレン（ＰＴＦＥ）、ポリクロロトリフルオロエチレン（ＰＣＴＦＥ）、ポリフッ化ビニリデン（ＰＶＤＦ）、ポリフッ化ビニル（ＰＶＦ）、ペルフルオロアルコキシフッ素系樹脂（ＰＦＡ）、四フッ化エチレン・六フッ化プロピレン共重合体（ＦＥＰ）、エチレン・四フッ化エチレン共重合体（ＥＴＦＥ）、クロロトリフルオロエチレン共重合体（ＥＣＴＦＥ）などがある。この実施例では、フッ素系樹脂シートＳ１・Ｓ２を、厚みが１００μｍの四フッ化エチレン・六フッ化プロピレン共重合体製のシートで形成して、両シートＳ１・Ｓ２に赤外線レーザービームを照射して凍結保存用バッグを形成するようにした。   The fluorine-based resin sheets S1 and S2 are formed as a transparent sheet that allows transmission of an infrared laser using any one of a fully fluorinated resin, a partially fluorinated resin, and a fluorinated resin copolymer as a forming material. is there. Specific forming materials include polytetrafluoroethylene (PTFE), polychlorotrifluoroethylene (PCTFE), polyvinylidene fluoride (PVDF), polyvinyl fluoride (PVF), perfluoroalkoxy fluorine-based resin (PFA), four fluorine. Ethylene / hexafluoropropylene copolymer (FEP), ethylene / tetrafluoroethylene copolymer (ETFE), chlorotrifluoroethylene copolymer (ECTFE), and the like. In this embodiment, the fluororesin sheets S1 and S2 are formed of a sheet made of a tetrafluoroethylene / hexafluoropropylene copolymer having a thickness of 100 μm, and both sheets S1 and S2 are irradiated with an infrared laser beam. Thus, a cryopreservation bag was formed.

図１１において凍結保存用バッグの製造装置は、基台１４上にシート固定構造１５と、シート固定構造１５で支持した２枚重ねのフッ素系樹脂シートＳ１・Ｓ２へ向かって、赤外線レーザービームを照射するレーザー装置１６と、シート固定構造１５を赤外線レーザービームに対して移動操作する走査構造１７などで構成してある。   In FIG. 11, the cryopreservation bag manufacturing apparatus irradiates an infrared laser beam toward the sheet fixing structure 15 on the base 14 and the two-layered fluororesin sheets S 1 and S 2 supported by the sheet fixing structure 15. And a scanning structure 17 for moving the sheet fixing structure 15 with respect to the infrared laser beam.

シート固定構造１５は、２枚重ねにしたフッ素系樹脂シートＳ１・Ｓ２を支持するシートテーブル１８と、シートテーブル１８に載置したフッ素系樹脂シートＳ１・Ｓ２を押え保持するシート押圧体１９とで構成する。シートテーブル１８は、熱伝導性に富むアルミニウム製のテーブル本体２０と、テーブル本体２０を固定支持するテーブル台２１とを備えており、テーブル台２１の後端の左右に、後述するヒンジ２９を装着するためのブラケット２２が上向きに突設してある（図１０参照）。フッ素系樹脂シートＳ１・Ｓ２が載置されるテーブル本体２０の上面（載置面）は面一の水平面として仕上げてある。   The sheet fixing structure 15 includes a sheet table 18 that supports the two fluorine resin sheets S1 and S2, and a sheet pressing body 19 that holds and holds the fluorine resin sheets S1 and S2 placed on the sheet table 18. Configure. The sheet table 18 includes a table body 20 made of aluminum having high thermal conductivity and a table base 21 that fixes and supports the table body 20, and hinges 29 described later are mounted on the left and right of the rear end of the table base 21. A bracket 22 for projecting is projected upward (see FIG. 10). The upper surface (mounting surface) of the table main body 20 on which the fluorine resin sheets S1 and S2 are mounted is finished as a flush horizontal surface.

シート押圧体１９は、赤外線透過作用と熱伝導作用に富む固体材料で構成される放熱体２５と、放熱体２５を支持する鋼材製の押圧枠２６とを備えている。放熱体２５は、赤外線レーザーに対して透明である単結晶シリコン円板で形成した。図１２に示すように、押圧枠２６は八角形状の金属枠体からなり、その中央に円形のレーザー窓２７が開口され、同窓２７の下面側に円形の装着座２８が形成してある。放熱体２５は装着座２８に嵌込み固定してある。   The sheet pressing body 19 includes a heat radiating body 25 made of a solid material rich in infrared transmission and heat conduction, and a steel-made pressing frame 26 that supports the heat radiating body 25. The radiator 25 was formed of a single crystal silicon disk that was transparent to the infrared laser. As shown in FIG. 12, the pressing frame 26 is made of an octagonal metal frame, a circular laser window 27 is opened at the center thereof, and a circular mounting seat 28 is formed on the lower surface side of the window 27. The radiator 25 is fitted and fixed to the mounting seat 28.

押圧枠２６の後部とテーブル台２１のブラケット２２とを、左右一対のヒンジ２９で連結することにより、シート押圧体１９の全体はシートテーブル１８で上下に揺動開閉可能に支持される。シート押圧体１９は、ハンドル３０を掴んで開閉操作することにより、図１２および図１３に示す溶着姿勢と、図１０に示す待機姿勢との間で変位操作できる。シート押圧体１９の後部中央に設けたゴムブロック３１を、ブラケット２２に固定したストッパー３２で受止めることにより、待機姿勢に開放操作したシート押圧体１９を、後傾姿勢のままで位置保持できるようにしている。この状態で、２枚重ねにしたフッ素系樹脂シートＳ１・Ｓ２をテーブル本体２０に載置し、あるいは溶着処理が終わった凍結保存用バッグのブランク体をテーブル本体２０から取り出すことができる。   By connecting the rear portion of the pressing frame 26 and the bracket 22 of the table base 21 with a pair of left and right hinges 29, the entire sheet pressing body 19 is supported by the sheet table 18 so as to be swingable up and down. The sheet pressing body 19 can be displaced between the welding posture shown in FIGS. 12 and 13 and the standby posture shown in FIG. 10 by grasping the handle 30 and opening / closing it. The rubber block 31 provided at the center of the rear part of the sheet pressing body 19 is received by a stopper 32 fixed to the bracket 22 so that the sheet pressing body 19 that has been opened to the standby position can be held in a rearward tilted position. I have to. In this state, the two-layered fluororesin sheets S 1 and S 2 can be placed on the table body 20, or the blank body of the cryopreservation bag after the welding process can be taken out from the table body 20.

レーザー装置１６は市販されている炭酸ガスレーザーユニットであって、左右に長い四角箱状のケースの側端から照射管３４を突設し、ケース内部の共振器から出力されたレーザー光を、変向ミラー３５で下向きに変向したのち、レーザーヘッドの内部に設けた集光レンズ３６で絞って、レーザーノズル３７から照射する。レーザー装置１６は、基台１４上に固定したレーザー台３８と、レーザー台３８に設けた高さ調整構造３９で支持されている。高さ調整構造３９は、複数のリンク対をＸ字状に組んで構成してあり、リンク対の上下中央に配置した調整ねじ軸４０を回動操作することにより、Ｘ字状のリンク対の交差角度を大小に変化させて、レーザー装置１６の上下高さを調整することができる。   The laser device 16 is a commercially available carbon dioxide laser unit. An irradiation tube 34 is projected from the side end of a rectangular box-like case that is long on the left and right sides, and laser light output from a resonator inside the case is changed. After turning downward by the direction mirror 35, the light is squeezed by the condenser lens 36 provided inside the laser head and irradiated from the laser nozzle 37. The laser device 16 is supported by a laser base 38 fixed on the base 14 and a height adjustment structure 39 provided on the laser base 38. The height adjustment structure 39 is configured by assembling a plurality of link pairs in an X shape. By rotating the adjustment screw shaft 40 arranged at the upper and lower centers of the link pairs, the height adjustment structure 39 The vertical height of the laser device 16 can be adjusted by changing the crossing angle to large or small.

走査構造１７は、基台１４上に固定されるＹ軸スライダー４３と、Ｙ軸スライダー４３の移動テーブル４５に固定されるＸ軸スライダー４４で、ＸＹステージとして構成してある。Ｙ軸スライダー４３およびＸ軸スライダー４４は、それぞれ市販されているボールねじ式の電動スライダーからなり、互いに直交する状態で配置してある。Ｘ軸スライダー４４の移動テーブル４６に、シートテーブル１８のテーブル台２１が固定してある。このように、テーブル台２１を基台１４に設けたＸＹステージで支持することにより、テーブル本体２０をレーザーノズル３７に対して自在に変位操作できる。これにより、Ｙ軸スライダー４３およびＸ軸スライダー４４の移動テーブル４５・４６を、予め設定されたＸＹ座標に従って移動操作しながら、フッ素系樹脂シートＳ１・Ｓ２に赤外線レーザービームを照射することにより、両シートＳ１・Ｓ２の界面に任意形状の溶着ビードを形成することができる。図１１において符号４７は、レーザー装置１６および走査構造１７の作動状態を制御する制御装置である。   The scanning structure 17 is configured as an XY stage with a Y-axis slider 43 fixed on the base 14 and an X-axis slider 44 fixed to a moving table 45 of the Y-axis slider 43. The Y-axis slider 43 and the X-axis slider 44 are each composed of a commercially available ball screw type electric slider, and are arranged in a state orthogonal to each other. The table 21 of the sheet table 18 is fixed to the moving table 46 of the X-axis slider 44. Thus, by supporting the table base 21 with the XY stage provided on the base 14, the table main body 20 can be freely displaced with respect to the laser nozzle 37. Thus, both the Y-axis slider 43 and the X-axis slider 44 are moved according to the preset XY coordinates while irradiating the fluororesin sheets S1 and S2 with infrared laser beams. A weld bead having an arbitrary shape can be formed at the interface between the sheets S1 and S2. In FIG. 11, reference numeral 47 is a control device that controls the operating states of the laser device 16 and the scanning structure 17.

凍結保存用バッグは以下の製造手順に従って製造する。レーザー装置１６は、赤外線レーザービームが２枚重ねにしたフッ素系樹脂シートＳ１・Ｓ２の界面で焦点を結ぶように、その集光レンズ３６の焦点調整を予め行っておく。図１０に示すようにシート押圧体１９を待機姿勢に開放操作したのち、テーブル本体２０の中央にフッ素系樹脂シートＳ１・Ｓ２を載置し位置決めしたうえで、シート押圧体１９を下降揺動させて溶着姿勢にする。次に、図１３に示すように、走査構造１７を作動させて溶着開始位置を赤外線レーザービームの照射位置に一致させ、レーザー装置１６と走査構造１７を同時に作動させながら、フッ素系樹脂シートＳ１・Ｓ２の界面に外郭線ビード１を一筆書き状に形成する。   The cryopreservation bag is manufactured according to the following manufacturing procedure. The laser device 16 adjusts the focus of the condensing lens 36 in advance so as to focus on the interface between the fluorine resin sheets S1 and S2 in which two infrared laser beams are overlapped. As shown in FIG. 10, after opening the sheet pressing body 19 to the standby position, the fluororesin sheets S1 and S2 are placed and positioned in the center of the table body 20, and then the sheet pressing body 19 is swung downward. To the welding position. Next, as shown in FIG. 13, the scanning structure 17 is operated so that the welding start position coincides with the irradiation position of the infrared laser beam, and while the laser device 16 and the scanning structure 17 are simultaneously operated, the fluororesin sheet S 1. The outline bead 1 is formed in a single stroke on the interface of S2.

図１ないし図９において、凍結保存用バッグの封口装置は、凍結保存用バッグの封口部５５（図９参照）を挟持固定するバッグクランプ装置５６と、バッグクランプ装置５６で挟持固定した封口部５５に向かって赤外線レーザービームを照射するレーザー装置５７と、バッグクランプ装置５６を移動操作する走査構造５８と、上記の各部材５６〜５８を支持するフレーム５９などで構成する。フレーム５９は、バッグクランプ装置５６および走査構造５８などが組付けられる上フレーム６０と、上フレーム６０を支持する下フレーム６１とを備えており、下フレーム６１の内部にレーザー装置５７と制御装置６２が配置してある。上フレーム６０の後傾する前部内面には、横長板状の走査ベース６５が固定され、その上下中央にバッグクランプ装置５６の左右移動を許す走査窓６６が開口してある。   1 to 9, the cryopreservation bag sealing device includes a bag clamping device 56 that clamps and fixes the sealing portion 55 (see FIG. 9) of the cryopreservation bag, and a sealing portion 55 that is clamped and fixed by the bag clamping device 56. A laser device 57 for irradiating an infrared laser beam toward the head, a scanning structure 58 for moving and operating the bag clamp device 56, a frame 59 for supporting each of the members 56 to 58, and the like. The frame 59 includes an upper frame 60 to which the bag clamp device 56 and the scanning structure 58 are assembled, and a lower frame 61 that supports the upper frame 60. A laser device 57 and a control device 62 are provided inside the lower frame 61. Is arranged. A horizontally long plate-like scanning base 65 is fixed to the inner surface of the front frame inclined backward, and a scanning window 66 that allows the bag clamp device 56 to move left and right is opened at the center of the upper and lower sides.

既に説明したように、凍結保存用バッグは、その収容部２に生体組織を充填したのち、脱気したうえで出入口３と直交する状態で、封口部５５に後述するシールビード１２５を形成する。図９に示すように、封口部５５は上ビード部４と出入口３の上端との間のシート領域であるが、封口部５５のうち上下中央部分において、シールビード１２５を出入口３と直交ないし交差する状態で形成するのが好ましい。   As already described, the cryopreservation bag is filled with a living tissue, and then deaerated, and a seal bead 125 described later is formed in the sealing portion 55 in a state orthogonal to the entrance / exit 3. As shown in FIG. 9, the sealing portion 55 is a sheet region between the upper bead portion 4 and the upper end of the entrance / exit 3, but the seal bead 125 is orthogonal to or intersects with the entrance / exit 3 in the upper and lower central portions of the sealing portion 55. It is preferable to form in such a state.

図１、図４および図５において、バッグクランプ装置５６は、走査ベース６５で支持される固定挟持ブロック６７と、固定挟持ブロック６７の後面に固定した一対のガイド軸６８で固定挟持ブロック６７に対して接離自在に支持される可動挟持ブロック６９と、可動挟持ブロック６９を固定挟持ブロック６７に対して接離操作するソレノイド（クランプアクチュエータ）７０（図１参照）と、可動挟持ブロック６９を前方へ向かって移動付勢する圧縮コイル形のばね７１などで構成する。固定挟持ブロック６７は、赤外線レーザービーム用の照射窓７２が開口してある左右横長のブロックベース７３と、赤外線透過作用と熱伝導作用に富む固体材料で構成される放熱体７４と、ブロックベース７３に装着されて放熱体７４を照射窓７２に臨む状態で支持する放熱体ホルダー７５を備えている。   1, 4, and 5, the bag clamp device 56 is fixed to the fixed clamping block 67 with a fixed clamping block 67 supported by the scanning base 65 and a pair of guide shafts 68 fixed to the rear surface of the fixed clamping block 67. A movable holding block 69 supported so as to be freely contacted and separated, a solenoid (clamp actuator) 70 (see FIG. 1) for moving the movable holding block 69 to and away from the fixed holding block 67, and the movable holding block 69 forward. It is composed of a compression coil spring 71 or the like that moves and energizes. The fixed clamping block 67 includes a horizontally long block base 73 in which an irradiation window 72 for infrared laser beams is opened, a heat radiator 74 made of a solid material rich in infrared transmission and heat conduction, and a block base 73. And a radiator holder 75 that supports the radiator 74 in a state of facing the irradiation window 72.

固定挟持ブロック６７のブロックベース７３は、クランプテーブル９１と上下調整構造とで支持するが、その詳細は後述する。放熱体７４は、赤外線透過作用と熱伝導作用に富む固体材料で構成する。放熱体７４を形成する固体材料としては、炭酸ガスレーザーを用いて溶着処理を行う関係上、赤外線レーザーに対して透明であるセレン化亜鉛、硫化亜鉛、シリコンのいずれかを適用できるが、この実施例では単結晶シリコンで放熱体７４を横長板状に形成した。放熱体７４は、鋼材製の放熱体ホルダー７５の上下中央に開口した照射スリット７６の前面を塞ぐ状態で、放熱体ホルダー７５に装着固定してある。放熱体７４と放熱体ホルダー７５の前面は面一になっている。放熱体ホルダー７５の左右両端は、ブロックベース７３に対してねじ込んだ第２ねじ体（第２装着具）７７で、着脱可能に装着してある（図４参照）。第２ねじ体７７は、ねじ軸の端部に操作つまみが固定してあるつまみねじからなり、操作つまみを指先で回転操作することにより放熱体ホルダー７５を着脱できる。   The block base 73 of the fixed clamping block 67 is supported by the clamp table 91 and the vertical adjustment structure, details of which will be described later. The heat radiating body 74 is made of a solid material rich in infrared transmission and heat conduction. As a solid material for forming the radiator 74, any one of zinc selenide, zinc sulfide, and silicon, which is transparent to the infrared laser, can be applied because of performing a welding process using a carbon dioxide gas laser. In the example, the heat radiator 74 is formed in a horizontally long plate shape with single crystal silicon. The radiator 74 is mounted and fixed to the radiator holder 75 in a state in which the front surface of the irradiation slit 76 opened at the upper and lower centers of the steel radiator holder 75 is closed. The front surfaces of the radiator 74 and the radiator holder 75 are flush with each other. The left and right ends of the radiator holder 75 are detachably mounted with second screw bodies (second mounting tools) 77 screwed into the block base 73 (see FIG. 4). The second screw body 77 is composed of a thumbscrew having an operation knob fixed to the end of the screw shaft, and the radiator holder 75 can be attached and detached by rotating the operation knob with a fingertip.

可動挟持ブロック６９は、熱伝導性に富むアルミニウム製の板材からなり、図１に示すように、先のガイド軸６８で前後に往復スライド自在に支持される左右一対のスライダー７９と、両スライダー７９で固定支持される板状の可動ベース８０と、可動ベース８０の前面の左右に固定した左右一対のブロック支持軸８１で支持してある。ブロック支持軸８１は、ブロックベース７３に形成した軸通口８２（図４参照）から前方へ突出しており、その前端に可動挟持ブロック６９が第１ねじ体（第１装着具）８３で着脱可能に装着してある。第１ねじ体８３は、第２ねじ体７７と同じつまみねじである。バッグクランプ装置５６による封口部５５の着脱を容易化し、確実化するために、可動挟持ブロック６９および固定挟持ブロック６７は、それぞれ走査窓６６の外面に臨ませてある。   The movable clamping block 69 is made of an aluminum plate material having high thermal conductivity. As shown in FIG. 1, a pair of left and right sliders 79 supported by the previous guide shaft 68 so as to be slidable back and forth, and both sliders 79. And a pair of left and right block support shafts 81 fixed to the left and right of the front surface of the movable base 80. The block support shaft 81 protrudes forward from a shaft opening 82 (see FIG. 4) formed in the block base 73, and a movable clamping block 69 can be attached to and detached from the front end thereof with a first screw body (first mounting tool) 83. It is attached to. The first screw body 83 is the same thumbscrew as the second screw body 77. In order to facilitate and ensure the attachment and detachment of the sealing portion 55 by the bag clamp device 56, the movable clamping block 69 and the fixed clamping block 67 face the outer surface of the scanning window 66, respectively.

先に説明したように、可動挟持ブロック６９はソレノイド７０とばね７１で前後操作されて、放熱体ホルダー７５に外接するクランプ姿勢と、放熱体ホルダー７５から前方へ離れる待機姿勢とに変位でき、常態においてはばね７１の付勢力を受けて待機姿勢に位置保持されている。図１に示すようにソレノイド７０は、ガイド軸６８の後端に固定したインナーベース８４に装着されており、その可動鉄心に連続する操作軸８５が可動ベース８０の左右中央に固定してある。図２・図３に示すように、封口装置の前側床面には、ソレノイド７０を作動させるフットスイッチ（スイッチ）８６が設けてあり、このスイッチ８６を踏込むと可動鉄心がソレノイド７０の内部へ向かって吸着されるので、可動挟持ブロック６９をばね７１の付勢力に抗してクランプ姿勢に切換えることができる。このクランプ姿勢は封口処理が終わるまで維持され、封口処理が終了したのち再度フットスイッチ８６を踏込むと、可動挟持ブロック６９はばね７１で待機姿勢に戻される。   As described above, the movable clamping block 69 is operated by the solenoid 70 and the spring 71 to move back and forth, and can be displaced between a clamping posture that circumscribes the radiator holder 75 and a standby posture that moves forward from the radiator holder 75. Is held in a standby position by receiving the biasing force of the spring 71. As shown in FIG. 1, the solenoid 70 is mounted on an inner base 84 fixed to the rear end of the guide shaft 68, and an operation shaft 85 continuing to the movable iron core is fixed to the left and right center of the movable base 80. As shown in FIGS. 2 and 3, a foot switch (switch) 86 for operating the solenoid 70 is provided on the front floor surface of the sealing device, and when the switch 86 is depressed, the movable iron core moves into the solenoid 70. The movable holding block 69 can be switched to the clamping posture against the urging force of the spring 71. This clamping posture is maintained until the sealing process is completed. When the foot switch 86 is stepped on again after the sealing process is completed, the movable clamping block 69 is returned to the standby posture by the spring 71.

上記のように、可動挟持ブロック６９を固定挟持ブロック６７のガイド軸６８に対して前後スライド自在に支持すると、可動挟持ブロック６９を固定挟持ブロック６７に対して円滑に前後移動でき、しかも両挟持ブロック６７・６９の挟持面の平行度を高度化できる。また、ガイド軸６８に固定したインナーベース８４にソレノイド７０を設けると、より簡単な構造のソレノイド７０で可動挟持ブロック６９を前後操作して、固定および可動の両挟持ブロック６７・６９で封口部５５を確実にクランプ固定できる。   As described above, when the movable clamping block 69 is supported slidably back and forth with respect to the guide shaft 68 of the fixed clamping block 67, the movable clamping block 69 can be smoothly moved back and forth with respect to the fixed clamping block 67, and both the clamping blocks can be moved. The parallelism of the clamping surfaces of 67 and 69 can be enhanced. Further, when the solenoid 70 is provided on the inner base 84 fixed to the guide shaft 68, the movable holding block 69 is operated in the front-rear direction by the solenoid 70 having a simpler structure, and the sealing portion 55 is formed by both the fixed and movable holding blocks 67 and 69. Can be securely clamped.

走査構造５８は、走査ベース６５と、走査ベース６５の走査窓６６の前縁上下に設けたガイドレール（ガイド体）８９と、ガイドレール８９で左右スライド自在に案内支持される合計４個のスライド体９０と、スライド体９０に固定される横長の四角枠クランプテーブル９１と、走査ベース６５の下部背面に固定される門型のインナーフレーム９２と、インナーフレーム９２に固定される左右横長の電動スライダー（走査アクチュエータ）９３などで構成する。クランプテーブル９１は横長の四角枠状に形成してあり、同テーブル９１と電動スライダー９３の移動テーブル９４とは、逆Ｌ字状の連動腕９５で連結してある。電動スライダー９３を作動させることにより、バッグクランプ装置５６を走査窓６６の一側端から他側端へ向かって走査移動することができる。このときの走査構造５８によるバッグクランプ装置５６の移動ストロークは、凍結保存用バッグの封口部５５の左右幅より充分に大きく設定してある。フレーム５９の前面の右上隅には、タッチパネル式のディスプレイ９６が設けてあり、ディスプレイ９６に表示されたスタートボタンをタッチすることにより、電動スライダー９３を作動させ、同時にレーザー装置５７から赤外線レーザービームを放射することができる。   The scanning structure 58 includes a scanning base 65, guide rails (guide bodies) 89 provided above and below the front edge of the scanning window 66 of the scanning base 65, and a total of four slides that are guided and supported by the guide rail 89 so as to be slidable to the left and right. Body 90, a horizontally long rectangular frame clamp table 91 fixed to the slide body 90, a gate-shaped inner frame 92 fixed to the lower back surface of the scanning base 65, and a left and right horizontally long electric slider fixed to the inner frame 92 (Scanning actuator) 93 and the like. The clamp table 91 is formed in a horizontally long rectangular frame shape, and the table 91 and the moving table 94 of the electric slider 93 are connected by a reverse L-shaped interlocking arm 95. By operating the electric slider 93, the bag clamp device 56 can be scanned and moved from one end of the scanning window 66 to the other end. The movement stroke of the bag clamping device 56 by the scanning structure 58 at this time is set sufficiently larger than the left and right width of the sealing portion 55 of the cryopreservation bag. A touch panel type display 96 is provided in the upper right corner of the front surface of the frame 59. By touching a start button displayed on the display 96, the electric slider 93 is operated, and at the same time, an infrared laser beam is emitted from the laser device 57. Can radiate.

バッグクランプ装置５６を上下に走査するために、フレーム５９の内部に上下走査構造を設けている。上下走査構造は、クランプテーブル９１に固定した縦長のガイドレール（上下ガイド）９７と、ガイドレール９７で往復スライド自在に支持される上下スライダー９８と、先に説明したインナーベース８４を介してバッグクランプ装置５６を上下操作するサーボモーター（上下走査アクチュエータ）９９などで構成する。図４に示すように、固定挟持ブロック６７のブロックベース７３は、左右一対の上下スライダー９８に固定してある。サーボモーター９９は、クランプテーブル９１の上部内面に固定したアクチュエータベース１００の上面に配置してあり、その回転動力をねじ軸１０１と、インナーベース８４に固定した雌ねじ体１０２で往復動作に変換して、バッグクランプ装置５６を上下に移動操作する。   In order to scan the bag clamp device 56 up and down, a vertical scanning structure is provided inside the frame 59. The vertical scanning structure includes a vertically long guide rail (vertical guide) 97 fixed to the clamp table 91, a vertical slider 98 supported by the guide rail 97 so as to be slidable back and forth, and a bag clamp via the inner base 84 described above. The apparatus 56 is constituted by a servo motor (up / down scanning actuator) 99 for operating up and down. As shown in FIG. 4, the block base 73 of the fixed clamping block 67 is fixed to a pair of left and right upper and lower sliders 98. The servo motor 99 is disposed on the upper surface of the actuator base 100 fixed to the upper inner surface of the clamp table 91, and its rotational power is converted into a reciprocating motion by the screw shaft 101 and the female screw body 102 fixed to the inner base 84. The bag clamp device 56 is moved up and down.

図２において、レーザー装置５７は市販されている炭酸ガスレーザーユニットであって、上下に長い四角箱状のレーザー発振器１０４と、レーザー発振器１０４の上端から突設される照射管１０５と、レーザー発振器１０４から出力されたレーザー光を斜め上向きに変向する変向ミラー１０６と、レーザー光を絞って放熱体７４へ向かって照射する集光レンズ１０７などで構成する。集光レンズ１０７の焦点位置を調整するために、インナーフレーム９２の後部に焦点調整構造を設けている。   In FIG. 2, a laser device 57 is a commercially available carbon dioxide laser unit, which is a rectangular box-shaped laser oscillator 104 that is long in the vertical direction, an irradiation tube 105 that protrudes from the upper end of the laser oscillator 104, and a laser oscillator 104. And a condensing lens 107 that squeezes the laser light and irradiates the heat radiation body 74 with the laser light. In order to adjust the focus position of the condenser lens 107, a focus adjustment structure is provided at the rear of the inner frame 92.

焦点調整構造は、インナーフレーム９２で支持されるレンズベース１０８と、レンズベース１０８に固定した左右一対のレンズガイド１０９と、各レンズガイド１０９で前後に往復スライド自在に支持される前後スライダー１１０と、前後スライダー１１０に固定されて集光レンズ１０７を支持するレンズホルダー１１１と、レンズホルダー１１１を前後操作するサーボモーター（焦点調整アクチュエータ）１１２などで構成する。サーボモーター１１２はレンズベース１０８の下面側に配置してあり、その回転動力をねじ軸１１３と、レンズホルダー１１１に固定した雌ねじ体１１４で往復動作に変換して、集光レンズ１０７の焦点位置を調整する。   The focus adjustment structure includes a lens base 108 supported by the inner frame 92, a pair of left and right lens guides 109 fixed to the lens base 108, and a front / rear slider 110 supported by each lens guide 109 so as to be slidable back and forth. The lens holder 111 is fixed to the front / rear slider 110 and supports the condenser lens 107, and the servo motor (focus adjustment actuator) 112 that operates the lens holder 111 back and forth. The servo motor 112 is arranged on the lower surface side of the lens base 108, and its rotational power is converted into a reciprocating operation by the screw shaft 113 and the female screw body 114 fixed to the lens holder 111, and the focal position of the condenser lens 107 is changed. adjust.

凍結保存用バッグの封口処理を行う過程で、レーザー装置５７から放出される赤外線レーザーが漏洩するおそれがあり、こうした漏洩レーザー光による被ばくを防ぐために、フレーム５９の全ての周側面および上面は防護壁１１７で覆われている。さらに、封口部５５に向かって照射された赤外線レーザーが漏洩するのを防ぐために、バッグクランプ装置５６の前面に防護カバー１１８を設けて、フレーム５９に設けたブラケット１１９とヒンジ１２０で揺動開閉可能に支持している（図１および図２参照）。凍結保存用バッグをバッグクランプ装置５６に着脱するとき、防護カバー１１８は図２に示すように上向きに開放揺動して、開放位置に位置保持することができる。図１および図２において、符号１２１は封口処理が終わった凍結保存用バッグが、誤って床面に落下するのを防ぐ落下防止板である。   In the process of sealing the cryopreservation bag, the infrared laser emitted from the laser device 57 may be leaked. In order to prevent exposure by such leaked laser light, all the peripheral side surfaces and the upper surface of the frame 59 are protective walls. 117. Furthermore, in order to prevent the infrared laser emitted toward the sealing portion 55 from leaking, a protective cover 118 is provided on the front surface of the bag clamp device 56 and can be swingably opened and closed by a bracket 119 and a hinge 120 provided on the frame 59. (Refer to FIG. 1 and FIG. 2). When the cryopreservation bag is attached to or detached from the bag clamp device 56, the protective cover 118 can swing upward and be held in the open position as shown in FIG. 1 and 2, reference numeral 121 denotes a fall prevention plate for preventing the cryopreservation bag after the sealing process from being accidentally dropped on the floor surface.

以下に凍結保存用バッグの封口手順を説明する。封口処理を行うのに先行して、レーザー装置５７の調整や集光レンズ１０７の焦点調整などを行って、赤外線レーザーの放射準備を行い、さらに、バッグクランプ装置５６は図３に示すホーム位置に位置させておく。また、ディスプレイ９６の表示を確認しながら溶着条件を設定して、スタンバイ状態にしておく。凍結保存用バッグは、その収容部２に生体組織を充填し、さらに脱気処理を行って封口部５５をシート状に扁平化しておく。この状態で、図６に示すように、封口部５５を可動挟持ブロック６９と放熱体７４との間に差込み、位置決めした状態でフットスイッチ８６を踏込んで、可動挟持ブロック６９をソレノイド７０で後退操作してクランプ姿勢にする。   The procedure for sealing the cryopreservation bag will be described below. Prior to performing the sealing process, adjustment of the laser device 57 and focus adjustment of the condenser lens 107 are performed to prepare for infrared laser radiation, and the bag clamp device 56 is moved to the home position shown in FIG. Keep it in place. Further, the welding condition is set while checking the display on the display 96, and the standby state is set. In the cryopreservation bag, the housing portion 2 is filled with a living tissue, and further, a deaeration process is performed to flatten the sealing portion 55 into a sheet shape. In this state, as shown in FIG. 6, the sealing portion 55 is inserted between the movable holding block 69 and the radiator 74, and the foot switch 86 is stepped on in the positioned state, and the movable holding block 69 is moved backward by the solenoid 70. To the clamping posture.

可動挟持ブロック６９をクランプ姿勢にした状態では、図７および図８に示すように、凍結保存用バッグの封口部５５の殆どの部分が可動挟持ブロック６９と放熱体７４とで挟持固定されている。この状態で、ディスプレイ９６に表示されたスタートボタンをタッチすることにより、レーザー装置５７から赤外線レーザービームが放熱体７４へ向かって放射され、同時に電動スライダー９３を作動させて、バッグクランプ装置５６をホーム位置から図３に向かって左側へ向かって一定速度で送り操作しながらシールビード１２５を形成する。   In the state where the movable holding block 69 is in the clamped position, as shown in FIGS. 7 and 8, most of the sealing portion 55 of the cryopreservation bag is held and fixed by the movable holding block 69 and the radiator 74. . In this state, by touching the start button displayed on the display 96, an infrared laser beam is emitted from the laser device 57 toward the heat radiating body 74, and at the same time, the electric slider 93 is operated to bring the bag clamp device 56 into the home position. The seal bead 125 is formed while being fed from the position toward the left side in FIG. 3 at a constant speed.

このとき、放熱体７４は赤外線レーザーを透過させるので、自身が赤外線レーザーを吸収して発熱することはない。また、シールビード１２５を形成する際に、ビード形成位置の周辺に溶着熱が伝導するが、封口部５５の後表面に達した溶着熱は、熱伝導性に優れた放熱体７４に吸収されて拡散される。同様に、封口部５５の前表面に達した溶着熱は、熱伝導性に優れた可動挟持ブロック６９に吸収されて拡散される。従って、封口部５５においては、図７の拡大図に示すように、フッ素系樹脂シートＳ１・Ｓ２の界面のみが溶着されることになる。   At this time, since the radiator 74 transmits the infrared laser, it does not generate heat by absorbing the infrared laser. Further, when the seal bead 125 is formed, welding heat is conducted around the bead forming position, but the welding heat reaching the rear surface of the sealing portion 55 is absorbed by the heat radiating body 74 having excellent thermal conductivity. Diffused. Similarly, the welding heat that has reached the front surface of the sealing portion 55 is absorbed and diffused by the movable holding block 69 having excellent thermal conductivity. Therefore, in the sealing part 55, as shown in the enlarged view of FIG. 7, only the interface of the fluorine resin sheets S1 and S2 is welded.

シールビード１２５が封口部５５の一側端から他側端にわたって形成されたら、赤外線レーザーの放射と、走査構造５８による送り操作を一時停止し、この状態で上下走査構造のサーボモーター９９を作動させて、バッグクランプ装置５６を赤外線レーザービームのスポット径の分だけ上方（または下方）へ移動操作する。さらに、走査構造５８を作動させてバッグクランプ装置５６を図３に向かって右方向へ送り操作しながら、赤外線レーザービームを封口部５５に放射して、往路時に形成したシールビード１２５の下方（または上方）に復路側のシールビード１２５を形成する。バッグクランプ装置５６がホーム位置まで復帰移動した状態では、図９に示すように、封口部５５に往復する２重のシールビード１２５が形成される。こののち、凍結保存用バッグを手で支えた状態で、フットスイッチ８６を踏込むことにより、バッグクランプ装置５６による封口部５５のクランプ作用を開放して、凍結保存用バッグを取出すことができる。なお、上下走査構造は、バッグクランプ装置５６がホーム位置まで復帰移動したとき初期状態に戻すか、往路のシールビード１２５を形成したのち、前回とは逆向きにバッグクランプ装置５６を移動操作してもよい。以後、上記の手順を繰り返し行うことにより、凍結保存用バッグの封口部５５にシールビード１２５を的確に形成することができる。   When the seal bead 125 is formed from one end of the sealing portion 55 to the other end, the infrared laser emission and the feeding operation by the scanning structure 58 are temporarily stopped, and the servo motor 99 of the vertical scanning structure is operated in this state. The bag clamp device 56 is moved upward (or downward) by the spot diameter of the infrared laser beam. Further, while operating the scanning structure 58 to feed the bag clamp device 56 to the right in FIG. 3, the infrared laser beam is emitted to the sealing portion 55, and below the seal bead 125 formed during the forward path (or A seal bead 125 on the return path side is formed on the upper side. In the state where the bag clamp device 56 has returned to the home position, a double seal bead 125 that reciprocates to the sealing portion 55 is formed as shown in FIG. After that, by stepping on the foot switch 86 while the cryopreservation bag is supported by hand, the clamping action of the sealing portion 55 by the bag clamp device 56 can be released, and the cryopreservation bag can be taken out. The vertical scanning structure returns to the initial state when the bag clamp device 56 returns to the home position or forms the outward seal bead 125 and then moves the bag clamp device 56 in the opposite direction to the previous time. Also good. Thereafter, the sealing beads 125 can be accurately formed in the sealing portion 55 of the cryopreservation bag by repeating the above procedure.

上記のように構成した封口装置によれば、可動挟持ブロック６９をクランプアクチュエータ７０で移動操作して、封口部５５をクランプしたのち、走査構造５８とレーザー装置５７を作動させることにより、フッ素系樹脂Ｓ１・Ｓ２を素材とする凍結保存用バッグの出入口３を自動的に封止することができる。凍結保存用バッグの封口部５５の封止作業は、医師や医療技術者などの現場ユーザーによって行われるが、封口部５５をバッグクランプ装置５６でクランプしたのちは、一連の溶着作業が自動的に行われるので、凍結保存用バッグの封口処理を安全にしかも的確に行うことができる。さらに、封口処理は常に一定の条件下で自動的に行われるので溶着結果にばらつきがなく、従って高度の封止機能を安定した状態で発揮できる封口処理を、誰もが手軽に行える凍結保存用バッグの封口装置を提供できる。   According to the sealing device configured as described above, the movable holding block 69 is moved and operated by the clamp actuator 70 to clamp the sealing portion 55, and then the scanning structure 58 and the laser device 57 are operated, whereby the fluororesin The entrance / exit 3 of the cryopreservation bag made of S1 and S2 can be automatically sealed. The sealing operation of the sealing portion 55 of the cryopreservation bag is performed by a field user such as a doctor or a medical engineer. After the sealing portion 55 is clamped by the bag clamp device 56, a series of welding operations are automatically performed. As a result, the sealing process of the cryopreservation bag can be performed safely and accurately. In addition, since the sealing process is always performed automatically under certain conditions, there is no variation in the welding results, and therefore, anyone can easily perform a sealing process that can exhibit a high level of sealing function in a stable state for cryopreservation. A bag sealing device can be provided.

可動挟持ブロック６９および固定挟持ブロック６７を走査窓６６の外面に臨ませるので、封口部５５のバッグクランプ装置５６に対する着脱操作を、自由空間に臨む走査窓６６の外面で容易に行うことができる。従って、凍結保存用バッグの位置や姿勢を確認しながら、封口部５５をバッグクランプ装置５６で適正にクランプでき、あるいは溶着作業が終わった凍結保存用バッグを確実に回収でき、全体として封口装置の使い勝手を向上できる。   Since the movable clamping block 69 and the fixed clamping block 67 face the outer surface of the scanning window 66, the attaching / detaching operation of the sealing portion 55 with respect to the bag clamp device 56 can be easily performed on the outer surface of the scanning window 66 facing the free space. Therefore, while confirming the position and posture of the cryopreservation bag, the sealing portion 55 can be properly clamped by the bag clamp device 56, or the cryopreservation bag after the welding operation can be reliably collected, and the sealing device as a whole can be recovered. Usability can be improved.

可動挟持ブロック６９を固定挟持ブロック６７のガイド軸６８に対して前後スライド自在に支持すると、可動挟持ブロック６９を固定挟持ブロック６７に対して円滑に前後移動でき、しかも両挟持ブロック６７・６９の挟持面の平行度を高度化できる。また、ガイド軸６８に固定したインナーベース８４にクランプアクチュエータ７０を設けると、より簡単な構造のクランプアクチュエータ７０で可動挟持ブロック６９を前後操作して、固定および可動の両挟持ブロック６７・６９で封口部５５を確実にクランプ固定できる。   When the movable clamping block 69 is supported slidably back and forth with respect to the guide shaft 68 of the fixed clamping block 67, the movable clamping block 69 can be smoothly moved back and forth with respect to the fixed clamping block 67, and the both clamping blocks 67 and 69 can be clamped. The parallelism of the surface can be enhanced. Further, when the clamp actuator 70 is provided on the inner base 84 fixed to the guide shaft 68, the movable clamping block 69 is operated back and forth with the clamp actuator 70 having a simpler structure, and sealing is performed with both the fixed and movable clamping blocks 67 and 69. The portion 55 can be securely clamped.

可動挟持ブロック６９は、ブロック支持軸８１に対して第１ねじ体８３を介して着脱可能に装着され、放熱体ホルダー７５は、ブロックベース７３に対して第２ねじ体７７を介して着脱可能に装着されている。こうした封口装置によれば、必要に応じて可動挟持ブロック６９および放熱体ホルダー７５を、ブロック支持軸８１およびブロックベース７３から取外して、生体組織が付着しているかもしれない可動挟持ブロック６９および放熱体ホルダー７５を滅菌処理できる。従って、可動挟持ブロック６９、放熱体７４、放熱体ホルダー７５の衛生管理を容易化して、凍結保存用バッグの封口部５５の口処理を衛生的に安全な状態で行うことができる。   The movable clamping block 69 is detachably attached to the block support shaft 81 via the first screw body 83, and the radiator holder 75 is detachably attached to the block base 73 via the second screw body 77. It is installed. According to such a sealing device, the movable clamping block 69 and the radiator holder 75 are removed from the block support shaft 81 and the block base 73 as necessary, and the movable clamping block 69 and the heat radiation to which the living tissue may adhere. The body holder 75 can be sterilized. Therefore, the hygienic management of the movable holding block 69, the radiator 74, and the radiator holder 75 can be facilitated, and the mouth treatment of the sealing portion 55 of the cryopreservation bag can be performed in a sanitary and safe state.

上記の実施例では、シールビード１２５を封口部５５の一側端から他側端にわたって連続形成したがその必要はなく、シールビード１２５は少なくとも出入口３を横断する状態で形成してあれば足りる。また、上記の実施例では、往路時に形成したシールビード１２５に隣接して復路側のシールビード１２５を２重に形成したが、往路側と復路側のいずれか一方のシールビード１２５のみで、封口部５５が封止してあってもよい。必要があれば、走査構造５８の送り移動操作に連動して、上下走査アクチュエータ９９を作動させることにより、シールビード１２５の形成パターンを連続波形や鋸刃形などに形成することができる。   In the above embodiment, the seal bead 125 is continuously formed from one end of the sealing portion 55 to the other end, but it is not necessary. The seal bead 125 only needs to be formed so as to cross at least the entrance 3. In the above embodiment, the return-side seal bead 125 is doubled adjacent to the seal bead 125 formed at the time of the outward path. However, the seal bead is sealed only by the seal bead 125 on either the outward-path side or the return-path side. The part 55 may be sealed. If necessary, the formation pattern of the seal bead 125 can be formed in a continuous waveform or a saw blade shape by operating the vertical scanning actuator 99 in conjunction with the feed movement operation of the scanning structure 58.

図１４および図１５は凍結保存用バッグの変形例を示す。そこでは、２枚重ねにした透明のフッ素系樹脂シートＳ１・Ｓ２に赤外線レーザービームを照射して、前記両シートＳ１・Ｓ２の界面に左右一対の外郭線ビード１を形成し、外郭線ビード１で挟まれた両シートＳ１・Ｓ２の間に生体組織を収容する収容部１３２と、収容部２に連続する通気口１３３と、通気口１３３に連続する抽気部１３４とを形成してなる。抽気部１３４の端部寄りは、第１シールビード１３５で封止されている。通気口１３３はバッグ壁の左右中央に形成してある。   14 and 15 show a modified example of the cryopreservation bag. The transparent fluororesin sheets S1 and S2 stacked in two are irradiated with an infrared laser beam to form a pair of left and right outer wire beads 1 at the interface between the two sheets S1 and S2. Between the sheets S1 and S2 sandwiched between the two, a storage part 132 that stores the living tissue, a vent 133 that continues to the storage 2 and a bleed part 134 that continues to the vent 133 are formed. The end portion of the bleed portion 134 is sealed with a first seal bead 135. The vent 133 is formed at the left and right center of the bag wall.

収容部１３２は、左右一対の左ビード部１３６および右ビード部１３７と、これら両ビード部１３６・１３７から通気口１３３へ向かって先すぼまり状に傾く肩ビード部１３８で区画されており、左右の両ビード部１３６・１３７の上端部はフッ素系樹脂シートＳ１・Ｓ２の短辺部と直交状に交差していて、両ビード部１３６・１３７の間に生体組織を収容部１３２に充填するための充填口１３９が開口してある。抽気部１３４は漏斗状に形成してある。図１５に示すように抽気部１３４の左右幅は、通気口１３３の左右幅より充分に大きく、収容部１３２の左右幅は抽気部１３４の左右幅よりさらに大きく設定してある。   The accommodating portion 132 is partitioned by a pair of left and right left bead portions 136 and a right bead portion 137, and shoulder bead portions 138 that incline in a tapered shape from both the bead portions 136 and 137 toward the vent hole 133. The upper end portions of the left and right bead portions 136 and 137 intersect the short side portions of the fluororesin sheets S1 and S2 in an orthogonal manner, and the living tissue is filled between the bead portions 136 and 137 in the accommodating portion 132. A filling port 139 is opened. The extraction part 134 is formed in a funnel shape. As shown in FIG. 15, the lateral width of the bleeder 134 is sufficiently larger than the lateral width of the vent 133, and the lateral width of the accommodating part 132 is set to be larger than the lateral width of the bleeder 134.

以上のように構成した凍結保存用バッグは、血液などの生体組織を収容部１３２に充填したのち封口処理を行うが、一連の作業は以下の手順に従って行う。
まず、図１５に示すように、充填口１３９を上にして開口したのち、生体組織を充填口１３９から収容部２に充填する（第１手順）。このとき、収容部１３２と同じ幅の充填口１３９を大きく開口した状態で生体組織を充填できるので、生体組織の収容部２への充填や注入を、簡便にしかも速やかに行うことができる。次に、収容部１３２内の空気を押し出しながら、充填口１３９側のバッグ壁を密着させて、図１６に示すように生体組織が充填された凍結保存用バッグの充填口１３９の側を第２シールビード１４０で封止する（第２手順）。この状態の収容部２には、僅かに空気が含まれていることが多く、この空気を放出するために、第１シールビード１３５に沿う切断線１４１に沿ってバッグ壁を切断して、第１シールビード１４０を含むバッグ壁を分離除去し、抽気部４の端部寄りに抽気開口１４２を形成する（第３手順）。 The cryopreservation bag configured as described above performs a sealing process after the living body tissue such as blood is filled in the storage portion 132, and a series of operations are performed according to the following procedure.
First, as shown in FIG. 15, after opening the filling port 139 upward, the living tissue is filled from the filling port 139 into the accommodating portion 2 (first procedure). At this time, since the living tissue can be filled in a state where the filling port 139 having the same width as the containing portion 132 is opened, the filling and injection of the living tissue into the containing portion 2 can be performed easily and quickly. Next, the bag wall on the filling port 139 side is brought into close contact with the air inside the housing portion 132 while pushing out the air in the housing portion 132, and the second filling port 139 side of the cryopreservation bag filled with the biological tissue is shown in FIG. Sealing with the seal bead 140 (second procedure). The container 2 in this state often contains a little air, and in order to release this air, the bag wall is cut along the cutting line 141 along the first seal bead 135, The bag wall including the one seal bead 140 is separated and removed, and the extraction opening 142 is formed near the end of the extraction unit 4 (third procedure).

抽気開口１４２が形成された凍結保存用バッグを、抽気部１３４が上、収容部１３２が下になる状態にして起立保持する。次に、収容部１３２内の生体組織を通気口１３３から抽気部１３４へ押し出して液位を上げ、さらに抽気部１３４のバッグ壁を密着させながら空気を抽気開口１４２から放出する（第４手順）。このとき、広幅の抽気部１３４のバッグ壁を密着させながら空気を抽気開口１４２から放出することにより抽気部１３４内の空気の全てを確実に排出できる。さらに、抽気部１３４から収容部１３２の上部に至る間のバッグ壁を密着させて仮封止部１４３を形成することができる。この状態で、仮封止部１４３を第３シールビード１４４で封止する（第５手順）ことにより、生体組織のみを収容部１３２内に封入することができる。   The cryopreservation bag in which the bleed opening 142 is formed is raised and held in a state where the bleed portion 134 is at the top and the storage portion 132 is at the bottom. Next, the living tissue in the storage part 132 is pushed out from the vent 133 to the extraction part 134 to raise the liquid level, and further, air is released from the extraction opening 142 while closely contacting the bag wall of the extraction part 134 (fourth procedure). . At this time, all the air in the bleed part 134 can be reliably discharged by discharging air from the bleed opening 142 while closely contacting the bag wall of the wide bleed part 134. Further, the temporary sealing portion 143 can be formed by closely contacting the bag wall from the bleed portion 134 to the upper portion of the accommodating portion 132. In this state, by sealing the temporary sealing portion 143 with the third seal bead 144 (fifth procedure), only the living tissue can be enclosed in the accommodating portion 132.

上記の凍結保存用バッグによれば、広幅の充填口１３９を大きく開口した状態で生体組織を充填できるので、生体組織の収容部１３２への充填や注入を、簡便にしかも速やかに行うことができる。また、収容部２内の生体組織を通気口１３３から広幅の抽気部１３４へ押し出して液位を上げ、さらに抽気部１３４のバッグ壁を密着させながら空気を抽気開口１４２から放出することができるので、収容部１３２に入り込んだ空気の脱気作業を楽にしかも速やかに行うことができる。第１シールビード１３５は、凍結保存用バッグの製造過程で形成しておくことができるが、第２シールビード１４０と第３シールビード１４４は封口装置を使用して封口処理する。   According to the above-described cryopreservation bag, since the living tissue can be filled with the wide filling port 139 opened widely, filling and injection of the living tissue into the accommodating portion 132 can be performed easily and quickly. . In addition, the living tissue in the container 2 can be pushed out from the vent 133 to the wide bleed part 134 to raise the liquid level, and air can be discharged from the bleed opening 142 while the bag wall of the bleed part 134 is closely attached. The deaeration work of the air that has entered the housing part 132 can be performed easily and quickly. The first seal beads 135 can be formed in the process of manufacturing the cryopreservation bag, but the second seal beads 140 and the third seal beads 144 are sealed using a sealing device.

上記以外に、クランプアクチュエータ７０はソレノイドである必要はなく、電動スライダー、電動シリンダー、リニアアクチュエータなどで構成してあってもよい。同様に、走査アクチュエータ９３は電動スライダー以外の、電動シリンダー、リニアアクチュエータなどで構成してあってもよい。さらに、上下調整アクチュエータ９９、および焦点調整アクチュエータ１１２は、電動スライダー、電動シリンダー、リニアアクチュエータなどで構成してあってもよい。レーザー発振器１０４は横長姿勢、あるいは前後に長い姿勢で配置することができる。本発明に係る封口装置は、とくにフッ素系樹脂シートＳ１・Ｓ２で形成した凍結保存用バッグの封口部を封口処理するのに好適であるが、封口処理はフッ素系樹脂シート以外の樹脂シートで形成した凍結保存用バッグにも等しく適用できるので、封口対象の凍結保存用バッグがフッ素系樹脂シートＳ１・Ｓ２で形成してあることは限定しない。   In addition to the above, the clamp actuator 70 does not need to be a solenoid, and may be configured by an electric slider, an electric cylinder, a linear actuator, or the like. Similarly, the scanning actuator 93 may be configured by an electric cylinder, a linear actuator, or the like other than the electric slider. Further, the vertical adjustment actuator 99 and the focus adjustment actuator 112 may be configured by an electric slider, an electric cylinder, a linear actuator, or the like. The laser oscillator 104 can be arranged in a horizontally long posture or a long posture in the front-rear direction. The sealing device according to the present invention is particularly suitable for sealing a sealing portion of a cryopreservation bag formed of fluorine-based resin sheets S1 and S2, but the sealing process is formed of a resin sheet other than the fluorine-based resin sheet. Therefore, it is not limited that the cryopreservation bag to be sealed is formed of the fluororesin sheets S1 and S2.

５５ 封口部
５６ バッグクランプ装置
５７ レーザー装置
５８ 走査構造
５９ フレーム
６５ 走査ベース
６７ 固定挟持ブロック
６９ 可動挟持ブロック
７０ クランプアクチュエータ（ソレノイド）
７４ 放熱体
９１ クランプテーブル
９３ 走査アクチュエータ（電動スライダー）
１０７ 集光レンズ
１２５ シールビード 55 Sealing Portion 56 Bag Clamp Device 57 Laser Device 58 Scanning Structure 59 Frame 65 Scanning Base 67 Fixed Clamping Block 69 Movable Clamping Block 70 Clamp Actuator (Solenoid)
74 Radiator 91 Clamp Table 93 Scanning Actuator (Electric Slider)
107 Condensing lens 125 Seal bead

Claims (5)

凍結保存用バッグの封口部（５５）を挟持固定するバッグクランプ装置（５６）と、バッグクランプ装置（５６）で挟持固定した封口部（５５）に向かって赤外線レーザービームを照射するレーザー装置（５７）と、上記の各部材（５６・５７）を支持するフレーム（５９）を備えており、
バッグクランプ装置（５６）は、フレーム（５９）に支持される固定挟持ブロック（６７）と、固定挟持ブロック（６７）に設けたガイド軸（６８）で固定挟持ブロック（６７）に対して接離自在に支持される可動挟持ブロック（６９）と、可動挟持ブロック（６９）を固定挟持ブロック（６７）に対して接離操作するクランプアクチュエータ（７０）とを含み、
レーザー装置（５７）は、レーザー発振器（１０４）と、レーザー発振器（１０４）から照射された赤外線レーザービームを、凍結保存用バッグの封口部（５５）に向かって集光する集光レンズ（１０７）を含み、
固定挟持ブロック（６７）は、赤外線レーザービーム用の照射窓（７２）が開口してあるブロックベース（７３）と、赤外線透過作用と熱伝導作用に富む固体材料で構成される放熱体（７４）と、ブロックベース（７３）に装着されて放熱体（７４）を前記照射窓（７２）に臨む状態で支持する放熱体ホルダー（７５）とを備えており、
固定挟持ブロック（６７）と可動挟持ブロック（６９）とで凍結保存用バッグの封口部（５５）を挟持固定した状態で、赤外線レーザービームを封口部（５５）に照射して、出入口（３）を横断する状態のシールビード（１２５）を封口部（５５）に形成することを特徴とする凍結保存用バッグの封口装置。 A bag clamp device (56) for holding and fixing the sealing portion (55) of the cryopreservation bag, and a laser device (57 for irradiating an infrared laser beam toward the sealing portion (55) clamped and fixed by the bag clamp device (56) ) and comprises a frame (59) supporting each member of the upper Symbol (56-57),
Bag clamp device (56) comprises a frame (59) to the supporting lifting is the solid Teikyoji block (67), with respect to the fixed clamping block guide shaft provided on the fixed clamping blocks (67) (68) (67) A movable clamping block (69) supported so as to be freely contactable and separable, and a clamp actuator (70) for operating the movable clamping block (69) to and from the fixed clamping block (67),
The laser device (57) includes a laser oscillator (104) and a condensing lens (107) that condenses the infrared laser beam emitted from the laser oscillator (104) toward the sealing portion (55) of the cryopreservation bag. Including
The fixed clamping block (67) includes a block base (73) in which an irradiation window (72) for infrared laser beams is opened, and a heat radiator (74) made of a solid material rich in infrared transmission and heat conduction. And a radiator holder (75) mounted on the block base (73) and supporting the radiator (74) in a state facing the irradiation window (72),
In a state where the sealing portion of the cryopreservation bag (55) was sandwiched and fixed de fixed clamping blocks (67) and the movable clamping block (69), by irradiating the infrared laser beam to the sealing portion (55), the doorway (3 A sealing bead for a cryopreservation bag, wherein a sealing bead (125) is formed in the sealing part (55). 可動挟持ブロック（６９）は、ガイド軸（６８）で前後に往復スライド自在に支持される左右一対のスライダー（７９）と、両スライダー（７９）で固定支持される板状の可動ベース（８０）と、可動ベース（８０）の前面の左右に固定した左右一対のブロック支持軸（８１）で支持されており、
ガイド軸（６８）に固定したインナーベース（８４）に、可動ベース（８０）とブロック支持軸（８１）を介して可動挟持ブロック（６９）を前後操作するクランプアクチュエータ（７０）が設けられており、
凍結保存用バッグの封口部（５５）を固定挟持ブロック（６７）の放熱体（７４）の外面にあてがった状態で、可動挟持ブロック（６９）をクランプアクチュエータ（７０）で操作して、固定および可動の両挟持ブロック（６７・６９）で封口部（５５）をクランプ固定できる請求項１に記載の凍結保存用バッグの封口装置。 The movable clamping block (69) includes a pair of left and right sliders (79) supported so as to be slidable back and forth by a guide shaft (68), and a plate-like movable base (80) fixedly supported by both sliders (79). And a pair of left and right block support shafts (81) fixed to the left and right of the front surface of the movable base (80),
The inner base (84) fixed to the guide shaft (68) is provided with a clamp actuator (70) for operating the movable clamping block (69) back and forth via the movable base (80) and the block support shaft (81). ,
With the sealing portion (55) of the cryopreservation bag placed on the outer surface of the radiator (74) of the fixed clamping block (67), the movable clamping block (69) is operated with the clamp actuator (70) to The sealing device for a cryopreservation bag according to claim 1, wherein the sealing portion (55) can be clamped and fixed by both movable clamping blocks (67, 69). 可動挟持ブロック（６９）が、ブロック支持軸（８１）に対して第１装着具（８３）を介して着脱可能に装着されており、
放熱体ホルダー（７５）が、ブロックベース（７３）に対して第２装着具（７７）を介して着脱可能に装着されており、
可動挟持ブロック（６９）および放熱体ホルダー（７５）を、ブロック支持軸（８１）およびブロックベース（７３）から取外して滅菌処理することができる請求項２に記載の凍結保存用バッグの封口装置。 The movable clamping block (69) is detachably mounted on the block support shaft (81) via the first mounting tool (83).
The radiator holder (75) is detachably attached to the block base (73) via the second attachment tool (77).
The sealing device for a cryopreservation bag according to claim 2, wherein the movable holding block (69) and the radiator holder (75) can be removed from the block support shaft (81) and the block base (73) and sterilized. フレーム（５９）の内部に集光レンズ（１０７）の焦点位置を調整する焦点調整構造が設けられており、
焦点調整構造は、フレーム（５９）に固定したインナーフレーム（９２）で支持されるレンズベース（１０８）と、レンズベース（１０８）に固定したレンズガイド（１０９）と、レンズガイド（１０９）で前後スライド自在に支持される前後スライダー（１１０）と、前後スライダー（１１０）に固定されて集光レンズ（１０７）を支持するレンズホルダー（１１１）と、レンズホルダー（１１１）を前後操作する焦点調整アクチュエータ（１１２）を備えており、
バッグクランプ装置（５６）で挟持固定された封口部（５５）の厚みに応じて、集光レンズ（１０７）の焦点位置を調整できる請求項２又は３に記載の凍結保存用バッグの封口装置。 A focus adjustment structure for adjusting the focal position of the condenser lens (107) is provided inside the frame (59).
The focus adjustment structure includes a lens base (108) supported by an inner frame (92) fixed to the frame (59) , a lens guide (109) fixed to the lens base (108), and a front and rear by a lens guide (109). A front / rear slider (110) supported slidably, a lens holder (111) fixed to the front / rear slider (110) to support the condenser lens (107), and a focus adjustment actuator for operating the lens holder (111) front / rear (112)
The bag sealing device for a cryopreservation bag according to claim 2 or 3, wherein the focal position of the condenser lens (107) can be adjusted according to the thickness of the sealing portion (55) clamped and fixed by the bag clamp device (56). フレーム（５９）の外面が、レーザー装置（５７）から漏洩する赤外線レーザーによる被ばくを防ぐ防護壁（１１７）で覆われており、
バッグクランプ装置（５６）の外面に、赤外線レーザーによる被ばくを防ぐ防護カバー（１１８）が開閉可能に設けてある請求項１から４のいずれかひとつに記載の凍結保存用バッグの封口装置。 The outer surface of the frame (59) is covered with a protective wall (117) that prevents exposure by an infrared laser leaking from the laser device (57),
The sealing device for a cryopreservation bag according to any one of claims 1 to 4, wherein a protective cover (118) for preventing exposure by an infrared laser is provided on the outer surface of the bag clamp device (56) so as to be openable and closable.
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