JP6175283B2 - Stent - Google Patents

Description

  The present invention relates to a stent used for treating a tubular portion of a human body.

A stent expands its stenosis or occlusion site to treat various diseases caused by stenosis or occlusion of blood vessels or other in vivo lumens (trachea, lymphatic vessels, ureters, etc.) It is a tubular medical device that is placed there in order to ensure safety.
Since the stent is inserted into the body from outside the body, the diameter is small at that time. The stent is expanded at the target stenosis or occlusion site to increase the diameter, and the lumen is held as it is.

  As a stent, a metal wire or a cylindrical shape obtained by processing a metal tube is generally used (see, for example, Patent Document 1). It is attached to a catheter or the like in a thin state, inserted into a living body, expanded by a certain method at a target site, and tightly fixed to the inner wall of the lumen to maintain the lumen shape. Stents are classified into self-expandable stents and balloon expandable stents according to function and placement method. The balloon expandable stent has no expansion function in the stent itself. After inserting the stent into the target site, the balloon is positioned in the stent to expand the balloon, and the stent is expanded (plastic deformation) by the expansion force of the balloon. Fix it in close contact with the inner surface of the lumen. This type of stent requires the above-described stent expansion operation.

  The purpose of stent placement is to prevent and reduce restenosis that occurs after a procedure such as PTCA.

  As described above, since the stent is placed in the living body, it is preferable that the stent is made of a material that is absorbed by the living body after the treatment is completed.

JP 2012-196264 A

  An object of one embodiment of the present invention is to provide a stent formed of a material that is absorbed by a living body.

Various aspects of the present invention are as follows.
[1] A stent having a cylindrical body formed of a wire, wherein the wire is made of magnesium or a magnesium alloy having an α-Mg phase.

[2] The stent according to [1], wherein the cylindrical body has a mesh shape knitted or woven with the wire.

[3] The stent according to [1], wherein the cylindrical body is a coil formed by winding the wire in a circular shape or a spiral shape.

[4] In any one of the above [1] to [3], the wire includes a first wire having a first wire diameter and a second wire having a second wire diameter, The stent has a wire diameter different from that of the second wire diameter.

[5] The stent according to any one of [1] to [3], wherein the wire has a tape-like wire.

[6] The stent according to any one of [1] to [3], wherein the wire includes a tape-shaped wire and a wire.

[7] The stent according to any one of [1] to [3], wherein the wire has a strand of two or more wires.

[8] A stent according to [6] or [7], wherein the following (Equation 1) is satisfied when the wire diameter of the wire is d1.
(Formula 1) 5 μm ≦ d1 <0.1 mm

[9] The stent according to any one of [1] to [8] above, wherein the surface of the wire is provided with irregularities.

[10] The stent according to any one of [1] to [9], wherein an average crystal grain size of the α-Mg phase is 2 μm or less.

[11] The stent according to any one of [1] to [10], wherein the wire is coated with a DLC film.

  By applying one embodiment of the present invention, a stent formed of a material that can be absorbed by a living body can be provided.

It is a figure showing some stents concerning one mode of the present invention. (A)-(E) are perspective views which show a various wire. (A) is a schematic diagram showing a state before the stent according to one embodiment of the present invention is inserted into the in-vivo lumen, and (B) is a diagram in which the stent shown in (A) is inserted into the in-vivo lumen. It is a schematic diagram which shows a back state.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. However, the present invention is not limited to the following description, and it will be easily understood by those skilled in the art that modes and details can be variously changed without departing from the spirit and scope of the present invention. Therefore, the present invention should not be construed as being limited to the description of the embodiments below.

(Embodiment 1)
FIG. 1 is a diagram illustrating a part of a stent according to one embodiment of the present invention.
The stent 1 is a stent for in-vivo indwelling that is in close contact with the in-vivo tissue by being deformed during the in-dwelling operation. The stent 1 has a cylindrical body formed of a wire rod 3, and this cylindrical body is a knitted or woven mesh shape of the wire rod 3.

  The stent 1 formed in a cylindrical body has an outer diameter for insertion into a lumen in a living body, and expands by applying a force that spreads in the radial direction from the inside, and is in close contact with the tissue in the living body. A balloon expandable stent. The stent is not limited to such a balloon expandable stent, and may be a so-called self-expandable stent.

  The wire 3 is made of a magnesium alloy having an α-Mg phase or magnesium. Magnesium is preferable because it has excellent biocompatibility and is harmless even if it is absorbed into the body during or after treatment.

When a wire having a wire diameter d1 is used as the wire, the following (Equation 1) should be satisfied. Thereby, a stent can be made compact.
(Formula 1) 5 μm ≦ d1 <0.1 mm

  The average crystal grain size of the α-Mg phase is preferably 2 μm or less. Thereby, high intensity | strength and high ductility are realizable.

  Specifically, the stent 1 is a tubular body knitted or woven by a plurality of wire members 3 extending obliquely. The wire 3 includes a first wire 31 and a second wire 32, and includes a large number of intersecting portions 5 where the first wire 31 and the second wire 32 intersect.

  In the present embodiment, the first wire 31 and the second wire 32 having the same wire diameter are used, but a first wire and a second wire having different wire diameters may be used. Further, the wire 3 may have a cross-sectional shape of a circle, an ellipse, a square, a rectangle, or the like, or may be a tape-like one shown in FIG. Wire strands may be used. Further, a tape-shaped wire and a wire may be used in combination, a stranded wire and a wire may be used in combination, or a tape-shaped wire and a stranded wire may be used in combination.

  By using a tape-shaped wire, it is possible to reduce the thickness while maintaining the strength of the wire. Further, the contact area between the wires can be increased by knitting or weaving using a tape-like wire, and the wire can be prevented from shrinking. Further, the hole diameter of the mesh can be controlled by controlling the tape width.

  The surface of the wire 3 is preferably provided with unevenness. The unevenness | corrugation here may be a thing with the surface roughened, and may be a big unevenness | corrugation as shown to FIG. 2 (B)-(E). By providing such irregularities on the wire, it is possible to make it difficult to return once the stent has spread. Also, depending on the shape of the irregularities, once the stent is expanded, it is fixed and held in the expanded state. Moreover, it can make it easy to apply | coat a chemical | medical agent to an unevenness | corrugation, and to hold | maintain.

  In addition, by using a stranded wire formed by two or more wires having a wire diameter of less than 0.1 mm as the wire 3, it is possible to control the absorption rate to the living body, improve the adhesion of the drug, Can be controlled.

  Examples of the drug include biologically and biologically active substances such as anticancer agents, immunosuppressive agents, antibiotics, anti-rheumatic agents, antithrombotic agents, HMG-CoA reductase inhibitors, ACE inhibitors, calcium antagonists. Antihyperlipidemic agent, integrin inhibitor, antiallergic agent, antioxidant, GPIIbIIIa antagonist, retinoid, flavonoid, carotenoid, lipid improver, DNA synthesis inhibitor, tyrosine kinase inhibitor, antiplatelet agent, anti-inflammatory It may be at least one selected from the group consisting of a drug, a biological material, an interferon, and a NO production promoting substance.

  The surface of the wire 3 may be coated with a DLC (Diamond Like Carbon) film. A DLC film is preferable because it is excellent in biocompatibility and is harmless even if it is absorbed into a living body during or after treatment. By controlling the thickness of the DLC film, the time when the stent is absorbed by the living body can be controlled.

  According to the present embodiment, since the stent 1 is produced by the cylindrical body formed of the magnesium alloy having the α-Mg phase or the wire 3 made of magnesium, a stent that is absorbed by the living body can be realized.

(Embodiment 2)
3A is a schematic diagram illustrating a state before the stent according to one embodiment of the present invention is inserted into a living body lumen, and FIG. 3B illustrates the stent illustrated in FIG. It is a schematic diagram which shows the state after inserting in a biological body lumen | bore.

  As shown in FIG. 3A, the stent 11 is placed inside the cylindrical device 21. This stent 11 has a cylindrical body formed of the wire 3, and this cylindrical body is a coil shape in which the wire 3 is wound in a circular shape or a spiral shape.

  The wire 3 can be the same as that in the first embodiment. As in the first embodiment, the surface of the wire 3 may be provided with irregularities, and a drug may be applied to the irregularities. The same drug as that in Embodiment 1 can be used. Further, as in the first embodiment, the surface of the wire 3 may be coated with a DLC film.

  The stent 11 placed in the tubular device 21 has an outer diameter for insertion into a living body lumen. The tubular device 21 is inserted into the living body lumen, and a force that spreads in the radial direction from the inside acts on the stent 11 pushed out from the tubular device 21 within the living body lumen. As a result, as shown in FIG. 3B, the inner diameter of the cylindrical body of the stent 11 is expanded, is in close contact with the in-vivo tissue, and is held in an expanded state. The stent is not limited to such a so-called self-expanding stent, and may be a balloon expandable stent.

  In the present embodiment, one wire 3 is wound in a circle or spiral to form the stent 11 with one coil. However, two or more wires are wound in a circle or a spiral to form 2. Two or more coils may be stacked to form a single stent.

  In the present embodiment, the same effect as in the first embodiment can be obtained.

  The magnesium alloy of the wire 3 in the first and second embodiments may be any one of the following [1] to [48].

[1] The magnesium alloy is an alloy containing Zn at a atom%, Y at b atom%, and the balance being Mg and inevitable impurities, wherein a and b are the following (formula 11) to (formula) 13) or (Formula 14) to (Formula 16), and may be made of an alloy having a crystal structure having a long-period laminated structure phase.
(Formula 11) 0.25 ≦ a <5.0
(Formula 12) 0.5 <b <5.0
(Formula 13) 2 / 3a-5 / 6 ≦ b
(Formula 14) 0.25 ≦ a ≦ 5.0
(Formula 15) 0.5 ≦ b ≦ 5.0
(Formula 16) 0.5a ≦ b

[2] The magnesium alloy is an alloy containing Zn at a atom%, Y at b atom%, and the balance being Mg and inevitable impurities, wherein a and b are the following (formula 11 ′), ( It may be made of an alloy that satisfies the expressions (12) and (13) and has a crystal structure having a long-period laminated structure phase.
(Formula 11 ′) 0.5 ≦ a <5.0
(Formula 12) 0.5 <b <5.0
(Formula 13) 2 / 3a-5 / 6 ≦ b

[3] The magnesium alloy according to the above [1] or [2] further contains at least one element selected from the group consisting of Yb, Tb, Sm and Nd in total c atom%, and c is It is preferable to satisfy the following (Equation 17) and (Equation 18).
(Formula 17) 0 ≦ c ≦ 3.0
(Formula 18) 0.1 (0.2) ≦ b + c ≦ 6.0

[4] The magnesium alloy according to the above [1] or [2] further contains at least one element selected from the group consisting of La, Ce, Pr, Eu, Mm and Gd in total c atom% C preferably satisfies the following (formula 19) and (formula 20).
(Formula 19) 0 ≦ c <2.0
(Formula 20) 0.2 ≦ b + c ≦ 6.0

[5] The magnesium alloy according to the above [1] or [2] further contains at least one element selected from the group consisting of La, Ce, Pr, Eu, Mm, and Gd in total c atom% C preferably satisfies the following (formula 20) and (formula 21).
(Formula 20) 0.2 ≦ b + c ≦ 6.0
(Formula 21) c / b ≦ 1.5

[6] The magnesium alloy according to the above [1] or [2] further contains at least one element selected from the group consisting of La, Ce, Pr, Eu, Mm and Gd in total c atom% C preferably satisfies the following (Equation 22) and (Equation 23).
(Formula 22) 0 ≦ c ≦ 3.0
(Formula 23) 0.1 <= b + c <= 6.0

[7] The magnesium alloy according to the above [1] or [2] further contains at least one element selected from the group consisting of Yb, Tb, Sm and Nd in total c atom%, La, It is preferable that at least one element selected from the group consisting of Ce, Pr, Eu, Mm and Gd is contained in total in d atom%, and c and d satisfy the following (formula 14) to (formula 16).
(Formula 14) 0 ≦ c ≦ 3.0
(Formula 15) 0 ≦ d <2.0
(Formula 16) 0.2 ≦ b + c + d ≦ 6.0

[8] The magnesium alloy according to the above [1] or [2] further contains at least one element selected from the group consisting of Yb, Tb, Sm and Nd in total c atom%, La, It is preferable that at least one element selected from the group consisting of Ce, Pr, Eu, Mm, and Gd is contained in total in d atom%, and c and d satisfy the following (formula 16) and (formula 17).
(Formula 16) 0.2 ≦ b + c + d ≦ 6.0
(Formula 17) d / b ≦ 1.5

[9] The magnesium alloy according to the above [1] or [2] further contains at least one element selected from the group consisting of Yb, Tb, Sm and Nd in total c atom%, La, It is preferable that at least one element selected from the group consisting of Ce, Pr, Eu, Mm and Gd is contained in total in d atomic%, and c and d satisfy the following (formula 18) to (formula 20).
(Formula 18) 0 ≦ c ≦ 3.0
(Formula 19) 0 ≦ d ≦ 3.0
(Formula 20) 0.1 ≦ b + c + d ≦ 6.0

[10] The magnesium alloy according to any one of [1] to [9], further includes Al, Th, Ca, Si, Mn, Zr, Ti, Hf, Nb, Ag, Sr, Sc, B, A total of at least one element selected from the group consisting of C, Sn, Au, Ba, Ge, Bi, Ga, In, Ir, Li, Pd, Sb and V is more than 0 atom% and less than 2.5 atom% It is good to contain.

[11] The magnesium alloy contains a atom% of Zn, contains a total of b atom% of at least one element selected from the group consisting of Dy, Ho, and Er, and the balance consists of Mg and inevitable impurities. It is an alloy, and a and b may satisfy the following (Formula 21) to (Formula 23) or (Formula 24) to (Formula 26) and be made of an alloy having a crystal structure having a long-period stacked structure phase.
(Formula 21) 0.1 ≦ a ≦ 5.0
(Formula 22) 0.1 ≦ b ≦ 5.0
(Formula 23) 0.5a-0.5 <= b
(Formula 24) 0.1 ≦ a ≦ 3.0
(Formula 25) 0.1 ≦ b ≦ 5.0
(Formula 26) 2a-3 ≦ b

[12] Magnesium alloy contains a atom% of Zn, contains a total of b atom% of at least one element selected from the group consisting of Dy, Ho, and Er, and the balance consists of Mg and inevitable impurities An alloy in which a and b satisfy the following (formula 21 ′), (formula 22 ′) and (formula 23) or (formula 24 ′), (formula 25 ′) and (formula 26), It may be made of an alloy having a crystal structure having a structural phase.
(Formula 21 ′) 0.2 ≦ a ≦ 5.0
(Formula 22 ′) 0.2 ≦ b ≦ 5.0
(Formula 23) 0.5a-0.5 <= b
(Formula 24 ′) 0.2 ≦ a ≦ 3.0
(Formula 25 ′) 0.2 ≦ b ≦ 5.0
(Formula 26) 2a-3 ≦ b

[13] The magnesium alloy according to the above [11] or [12] further contains at least one element selected from the group consisting of Yb, Sm and Nd in total c atom%, where c is (Expression 27) and (Expression 28) should be satisfied.
(Formula 27) 0 ≦ c ≦ 3.0
(Formula 28) 0.1 (0.2) <= b + c <= 6.0

[14] The magnesium alloy according to the above [11] or [12] further contains at least one element selected from the group consisting of La, Ce, Pr, Eu and Mm in total c atom%, c should satisfy the following (formula 29) and (formula 30).
(Formula 29) 0 ≦ c ≦ 3.0
(Formula 30) 0.1 (0.2) ≦ b + c ≦ 6.0

[15] The magnesium alloy according to the above [11] or [12] further contains at least one element selected from the group consisting of Yb, Sm, and Nd in total c atom%, and La, Ce, It is preferable that at least one element selected from the group consisting of Pr, Eu, and Mm is contained in d atom% in total, and c and d satisfy the following (formula 31) to (formula 33).
(Formula 31) 0 ≦ c ≦ 3.0
(Formula 32) 0 ≦ d ≦ 3.0
(Formula 33) 0.1 (0.2) ≦ b + c + d ≦ 6.0

[16] The magnesium alloy according to any one of [11] to [15] above further contains at least one of Y and Gd in a total of y atomic%, wherein y is represented by the following (Formula 34) and (Formula 35) should be satisfied.
(Formula 34) 0 ≦ y ≦ 4.9
(Formula 35) 0.1 ≦ b + y ≦ 5.0

[17] The magnesium alloy according to any one of [11] to [16], further includes Al, Th, Ca, Si, Mn, Zr, Ti, Hf, Nb, Ag, Sr, Sc, B, A total of at least one element selected from the group consisting of C, Sn, Au, Ba, Ge, Bi, Ga, In, Ir, Li, Pd, Sb and V is more than 0 atom% and less than 2.5 atom% It is good to contain.

[18] It is preferable that at least a part of the long-period laminate structure phase included in the magnesium alloy according to any one of [11] to [17] is curved or bent.

[19] The magnesium alloy contains Zn by a atom%, and contains at least one element selected from the group consisting of Gd, Tb, Tm and Lu in total b atom%, with the balance being Mg and inevitable impurities A and b satisfy the following (Formula 41) to (Formula 43) or (Formula 44) to (Formula 46), and are composed of an alloy having a crystal structure having a long-period laminated structure phase. Good.
(Formula 41) 0.1 ≦ a ≦ 5.0
(Formula 42) 0.25 ≦ b ≦ 5.0
(Formula 43) 0.5a−0.5 ≦ b
(Formula 44) 0.1 ≦ a ≦ 3.0
(Formula 45) 0.25 ≦ b ≦ 5.0
(Formula 46) 2a-3 ≦ b

[20] The magnesium alloy contains Zn by a atom%, and contains at least one element selected from the group consisting of Gd, Tb, Tm and Lu in total b atom%, with the balance being Mg and inevitable impurities A and b satisfy the following (formula 41 ′), (formula 42 ′) and (formula 43) or (formula 44 ′), (formula 45 ′) and (formula 46), and are long It is good to consist of an alloy provided with the crystal structure which has a periodic laminated structure phase.
(Formula 41 ′) 0.2 ≦ a ≦ 5.0
(Formula 42 ′) 0.5 ≦ b ≦ 5.0
(Formula 43) 0.5a−0.5 ≦ b
(Formula 44 ′) 0.2 ≦ a ≦ 3.0
(Formula 45 ′) 0.5 ≦ b ≦ 5.0
(Formula 46) 2a-3 ≦ b

[21] The magnesium alloy according to the above [19] or [20] further contains at least one element selected from the group consisting of Yb, Sm and Nd in total c atom%, and c is: (Expression 47) and (Expression 48) should be satisfied.
(Formula 47) 0 ≦ c ≦ 3.0
(Formula 48) 0.25 (0.5) ≦ b + c ≦ 6.0

[22] The magnesium alloy according to the above [19] or [20] further contains at least one element selected from the group consisting of La, Ce, Pr, Eu and Mm in total c atom%, c should satisfy the following (formula 49) and (formula 50).
(Formula 49) 0 ≦ c ≦ 2.0
(Formula 50) 0.25 (0.5) ≦ b + c ≦ 6.0

[23] The magnesium alloy according to the above [19] or [20] further contains at least one element selected from the group consisting of Yb, Sm, and Nd in a total of c atomic%, and La, Ce, It is preferable that at least one element selected from the group consisting of Pr, Eu, and Mm is contained in a total of d atomic%, and c and d satisfy the following (formula 51) to (formula 53).
(Formula 51) 0 ≦ c ≦ 3.0
(Formula 52) 0 ≦ d ≦ 2.0
(Formula 53) 0.25 (0.5) ≦ b + c + d ≦ 6.0

[24] In the magnesium alloy according to any one of [19] to [23], the total amount of at least one element selected from the group consisting of Dy, Ho, and Er is more than 0 atomic%. It is good to contain 5 atomic% or less.

[25] The magnesium alloy according to any one of [19] to [23] may further contain Y in an amount of more than 0 atomic% and not more than 1.0 atomic%.

[26] The magnesium alloy according to any one of [19] to [25], further comprising at least one element selected from the group consisting of Gd, Tb, Tm, and Lu in total less than 3 atomic% It is good to contain.

[27] The magnesium alloy according to any one of [19] to [26], further includes Al, Th, Ca, Si, Mn, Zr, Ti, Hf, Nb, Ag, Sr, Sc, B, and It is preferable to contain at least one element selected from the group consisting of C more than 0 atomic% and 2.5 atomic% or less in total.

[28] It is preferable that at least a part of the long-period laminate structure phase included in the magnesium alloy according to any one of [19] to [27] is curved or bent.

[29] The magnesium alloy contains a total of at least one metal of Cu, Ni, and Co, and is at least one selected from the group consisting of Y, Dy, Er, Ho, Gd, Tb, and Tm. In total, and the balance is Mg and inevitable impurities, wherein a and b satisfy the following (formula 61) to (formula 63) and have a long-period laminated structure phase: A magnesium alloy comprising an alloy having a crystal structure.
(Formula 61) 0.2 ≦ a ≦ 10
(Formula 62) 0.2 ≦ b ≦ 10
(Formula 63) 2 / 3a-2 / 3 <b

[30] The magnesium alloy according to [29] further contains c atomic% of Zn, and the a and c preferably satisfy the following (formula 64).
(Formula 64) 0.2 <a + c ≦ 15

[31] In the above [30], the a and c may further satisfy the following (formula 65).
(Formula 65) c / a ≦ 1/2

[32] The magnesium alloy according to any one of [29] to [31] is further at least one selected from the group consisting of La, Ce, Pr, Nd, Sm, Eu, Yb, and Lu. It is preferable that the element contains d atomic% in total, and the b and d satisfy the following (formula 66).
(Formula 66) 0.2 <b + d ≦ 15

[33] In the above [32], b and d may further satisfy the following (formula 67).
(Formula 67) d / b ≦ 1/2

[34] The magnesium alloy according to any one of [29] to [33], further includes Zr, Ti, Mn, Al, Ag, Sc, Sr, Ca, Si, Hf, Nb, B, C, Containing at least one element selected from the group consisting of Sn, Au, Ba, Ge, Bi, Ga, In, Ir, Li, Pd, Sb, V, Fe, Cr, and Mo in a total of e atomic%, It is preferable that e satisfies the following (Formula 68).
(Formula 68) 0 <e ≦ 2.5

[35] In the above [34], e, a, b, and d may further satisfy the following (formula 69).
(Formula 69) e / (a + b + c + d) ≦ 1/2

[36] The magnesium alloy contains Zn by a atom%, and contains at least one element of Y, Dy, Ho and Er in total b atom%, La, Ce, Pr, Nd, Sm, Gd, Tb and It is an alloy containing at least one element selected from the group consisting of Yb in a total of c atomic% and the balance being Mg and inevitable impurities, wherein a, b and c are the following (formula 71) to (formula 74), and may be made of an alloy having a crystal structure having a long-period laminated structure phase.
(Formula 71) 0.2 <= a <= 5.0
(Formula 72) 0.2 ≦ b ≦ 5.0
(Formula 73) 2a-3 ≦ b
(Formula 74) 0.05b ≦ c <0.75b

[37] The magnesium alloy according to [36] may further contain d atomic% of Al and satisfy the following (formula 75).
(Formula 75) 0.05b ≦ d <0.75b

[38] The magnesium alloy according to the above [36] or [37] may contain a total of b atom% of at least two elements of Y, Dy, Ho and Er.

[39] The magnesium alloy contains Zn by a atom%, and contains at least one element of Gd and Tb by a total of b atom%, Al, Y, La, Ce, Pr, Nd, Sm, Dy, Ho, An alloy containing at least one element selected from the group consisting of Er, Tm, and Yb in a total amount of c atomic%, with the balance being Mg and inevitable impurities, wherein a, b, and c are represented by the following formula (Formula 81 ) To (Equation 84) and is preferably made of an alloy having a crystal structure having a long-period laminated structure phase.
(Formula 81) 0.2 ≦ a ≦ 5.0
(Formula 82) 0.2 ≦ b ≦ 5.0
(Formula 83) 2a-3 ≦ b
(Formula 84) 0.05b ≦ c <0.75b

[40] A magnesium alloy is an alloy containing Al at a atom%, Gd at b atom%, the balance being Mg and inevitable impurities, wherein a and b are the following (formula 91) and (formula) 92), and may be made of an alloy having a crystal structure having a long-period stacked structure phase or a phase containing a close-packed atomic area layer defect.
(Formula 91) 0.01 ≦ a ≦ 2.0
(Formula 92) 0.2 ≦ b ≦ 5.0

  In the present specification, the close-packed atomic area layer defect is a dilute layer in which zinc and rare earth elements, which are solute atoms, continue in the stacking direction along the close-packed atomic plane (a solute atom-concentrated layer defect). Atomic layer), and the solute atom-enriched diatomic layer has no periodicity in the stacking direction over a long distance.

[41] The magnesium alloy contains Zn by a atom%, and contains at least one element selected from the group consisting of Y, Dy, Ho, Er, Gd, Tb and Tm in total b atom%, Al In which the balance is Mg and inevitable impurities, and a, b, and c satisfy the following (formula 101) to (formula 104) and have a long-period laminated structure phase or a close-packed atom It is good to consist of an alloy provided with the crystal structure which has a phase containing an area layer defect.
(Formula 101) 0.2 ≦ a ≦ 5.0
(Formula 102) 0.2 ≦ b ≦ 5.0
(Formula 103) 2a-3 ≦ b
(Formula 104) 0.05b ≦ c <0.75b

[42] The magnesium alloy according to the above [41] further includes Li, Sn, Di, La, Ce, Pr, Nd, Sm, Eu, Mm, Yb, Th, Ca, Si, Mn, Zr, Ti, At least one element selected from the group consisting of Hf, Nb, Ag, Sr, Sc, B, C, Ga, and Ge is contained in total in d atomic%, and d may satisfy the following (Formula 105). .
(Formula 105) 0 ≦ d ≦ b / 2

[43] The magnesium alloy may be composed of any of the following chemical components (A) to (G).
(A) mass%, Al: 0.1 to 12.0%, Mn: 0.1 to 1.0%, the balance being Mg and impurities (B) mass%, Al: 0.1 to 12 0.0%, containing Mn: 0.1 to 1.0%, further containing one or more elements selected from Zn: 0.5 to 2.0%, Si: 0.3 to 2.0%, The balance is Mg and impurities (C) mass%, Zn: 1.0-10.0%, Zr: 0.4-2.0%, the balance is Mg and impurities (D) mass%, Zn: 1.0 to 10.0%, Zr: 0.4 to 2.0%, Mn: 0.5 to 2.0%, the balance being Mg and impurities (E) mass%, Zn: 1.0 -10.0%, rare earth element: 1.0-3.0%, the balance is Mg and impurities (F) mass%, Zr: 0.4-2.0%, rare earth element: 1.0- Including 3.0% The balance is Mg and impurities (G) mass%, Zn: 1.0-10.0%, Mn: 0.1-1.0, Cu: 0.5-
Contains 2.0%, the balance being Mg and impurities

[44] The magnesium alloy contains Zn at a atom%, Y contains b atom%, and a and b satisfy the following (formula 11) to (formula 13) or (formula 14) to (formula 16). It may be made of an alloy having a crystal structure having a long-period laminated structure phase.
(Formula 11) 0.25 ≦ a <5.0
(Formula 12) 0.5 <b <5.0
(Formula 13) 2 / 3a-5 / 6 ≦ b
(Formula 14) 0.25 ≦ a ≦ 5.0
(Formula 15) 0.5 ≦ b ≦ 5.0
(Formula 16) 0.5a ≦ b

[45] The magnesium alloy contains a atom% of Zn and contains a total of b atom% of at least one element selected from the group consisting of Dy, Ho, and Er. ) To (Equation 23) or (Equation 24) to (Equation 26), and may be made of an alloy having a crystal structure having a long-period laminated structure phase.
(Formula 21) 0.1 ≦ a ≦ 5.0
(Formula 22) 0.1 ≦ b ≦ 5.0
(Formula 23) 0.5a-0.5 <= b
(Formula 24) 0.1 ≦ a ≦ 3.0
(Formula 25) 0.1 ≦ b ≦ 5.0
(Formula 26) 2a-3 ≦ b

[46] The magnesium alloy contains Zn by a atom%, and contains at least one element selected from the group consisting of Gd, Tb, Tm and Lu in total b atom%, and a and b are the following ( It may be made of an alloy that satisfies the formulas 41 to 43 or the formulas 44 to 46 and has a crystal structure having a long-period laminated structure phase.
(Formula 41) 0.1 ≦ a ≦ 5.0
(Formula 42) 0.25 ≦ b ≦ 5.0
(Formula 43) 0.5a−0.5 ≦ b
(Formula 44) 0.1 ≦ a ≦ 3.0
(Formula 45) 0.25 ≦ b ≦ 5.0
(Formula 46) 2a-3 ≦ b

[47] The magnesium alloy contains a total of at least one metal of Cu, Ni, and Co, and is at least one selected from the group consisting of Y, Dy, Er, Ho, Gd, Tb, and Tm. These elements are preferably contained in an amount of b atom%, and a and b satisfy the following (formula 61) to (formula 63) and are made of an alloy having a crystal structure having a long-period laminated structure phase.
(Formula 61) 0.2 ≦ a ≦ 10
(Formula 62) 0.2 ≦ b ≦ 10
(Formula 63) 2 / 3a-2 / 3 <b

[48] The magnesium alloy contains Al at a atom%, Gd at b atom%, a and b satisfy the following (formula 91) and (formula 92), and have a long-period laminated structure phase It is good to consist of an alloy provided with.
(Formula 91) 0.01 ≦ a ≦ 2.0
(Formula 92) 0.2 ≦ b ≦ 5.0

DESCRIPTION OF SYMBOLS 1 ... Stent 3 ... Wire 5 ... Intersection 11 ... Stent 21 ... Cylindrical instrument 31 ... 1st wire 32 ... 2nd wire

Claims (15)

A stent having a cylindrical body formed of a wire,
Ri Rana or magnesium alloy, wherein the wire has a alpha-Mg phase,
The magnesium alloy contains Zn at a atom%, Y contains b atom%, a and b satisfy the following (formula 11) to (formula 13) or (formula 14) to (formula 16), and are long. the stent according to claim Rukoto such an alloy having a crystal structure having a period stacking ordered structure phase.
(Formula 11) 0.25 ≦ a <5.0
(Formula 12) 0.5 <b <5.0
(Formula 13) 2 / 3a-5 / 6 ≦ b
(Formula 14) 0.25 ≦ a ≦ 5.0
(Formula 15) 0.5 ≦ b ≦ 5.0
(Formula 16) 0.5a ≦ b A stent having a cylindrical body formed of a wire,
Ri Rana or magnesium alloy, wherein the wire has a alpha-Mg phase,
The magnesium alloy contains Zn by a atom%, and contains at least one element selected from the group consisting of Dy, Ho and Er in total b atom%, and a and b are the following (formula 21) to (formula 23) or (expression 24) - filled with (equation 26), the stent characterized by Rukoto such an alloy having a crystal structure having a long period stacking ordered structure phase.
(Formula 21) 0.1 ≦ a ≦ 5.0
(Formula 22) 0.1 ≦ b ≦ 5.0
(Formula 23) 0.5a-0.5 <= b
(Formula 24) 0.1 ≦ a ≦ 3.0
(Formula 25) 0.1 ≦ b ≦ 5.0
(Formula 26) 2a-3 ≦ b A stent having a cylindrical body formed of a wire,
Ri Rana or magnesium alloy, wherein the wire has a alpha-Mg phase,
The magnesium alloy contains a atomic% of Zn, and contains a total of b atomic% of at least one element selected from the group consisting of Gd, Tb, Tm, and Lu. ) - (formula 43) or (expression 44) - (satisfies expression 46), the stent characterized by Rukoto such an alloy having a crystal structure having a long period stacking ordered structure phase.
(Formula 41) 0.1 ≦ a ≦ 5.0
(Formula 42) 0.25 ≦ b ≦ 5.0
(Formula 43) 0.5a−0.5 ≦ b
(Formula 44) 0.1 ≦ a ≦ 3.0
(Formula 45) 0.25 ≦ b ≦ 5.0
(Formula 46) 2a-3 ≦ b A stent having a cylindrical body formed of a wire,
Ri Rana or magnesium alloy, wherein the wire has a alpha-Mg phase,
The magnesium alloy contains a total of at least one metal of Cu, Ni and Co, and contains at least one element selected from the group consisting of Y, Dy, Er, Ho, Gd, Tb and Tm. the containing b atomic% in total, a and b satisfy the following equation (61) - (wherein 63), characterized by Rukoto such an alloy having a crystal structure having a long period stacking ordered structure phase stents.
(Formula 61) 0.2 ≦ a ≦ 10
(Formula 62) 0.2 ≦ b ≦ 10
(Formula 63) 2 / 3a-2 / 3 <b A stent having a cylindrical body formed of a wire,
Ri Rana or magnesium alloy, wherein the wire has a alpha-Mg phase,
The magnesium alloy has a crystal structure containing a atomic% Al, b atomic% Gd, a and b satisfying the following (formula 91) and (formula 92), and having a long-period laminated structure phase: stent characterized by Rukoto such from the alloy.
(Formula 91) 0.01 ≦ a ≦ 2.0
(Formula 92) 0.2 ≦ b ≦ 5.0 In any one of Claims 1 thru | or 5 ,
The stent is characterized in that the cylindrical body is a mesh-like one knitted or woven with the wire. In any one of Claims 1 thru | or 5 ,
The said cylindrical body is a coil-shaped thing which wound the said wire rod circularly or spirally, The stent characterized by the above-mentioned. In any one of Claims 1 thru | or 7 ,
The wire has a first wire having a first wire diameter and a second wire having a second wire diameter,
The stent according to claim 1, wherein the first wire diameter is different from the second wire diameter. In any one of Claims 1 thru | or 7 ,
The stent, wherein the wire has a tape-like wire. In any one of Claims 1 thru | or 7 ,
The said wire has a tape-shaped wire and a wire, The stent characterized by the above-mentioned. In any one of Claims 1 thru | or 7 ,
The stent, wherein the wire has a stranded wire of two or more wires. In claim 10 or 11 ,
A stent that satisfies the following (formula 1) when the wire diameter of the wire is d1.
(Formula 1) 5 μm ≦ d1 <0.1 mm In any one of Claims 1 thru | or 12 ,
A stent characterized in that irregularities are provided on the surface of the wire. In any one of Claims 1 thru | or 13 ,
The average crystal grain size of the α-Mg phase is 2 μm or less. In any one of Claims 1 thru | or 14 ,
The stent, wherein the wire is coated with a DLC film.

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