JP6166697B2 - Optical coherence tomography device - Google Patents

Description

  The present invention relates to an optical coherence tomography apparatus, and more particularly to an optical coherence tomography apparatus for acquiring a three-dimensional tomographic image mainly used in medicine.

  A light source in which the wave number of light continuously changes (sweep) with respect to time is called a wavelength-swept light source. In such a light source, the wave number of light sweeps linearly (linearly) with respect to time. The light source to be called is called a wave number linear wavelength swept light source.

  As an optical coherence tomography device, the interference waveform signal obtained when using a wavelength variable light source that is not wave number linear is converted (resampled) into an interference waveform signal equivalent to that when a wavelength variable light source that is wave number linear is used. There is known a Swept Source Optical Coherence Tomography (SS-OCT) system that acquires a three-dimensional tomographic image (Non-Patent Document 1). Non-Patent Document 1 describes an SS-OCT system configured as shown in FIG. The SS-OCT system shown in FIG. 1 includes a light source 101 that performs wavelength sweeping so as to obtain a comb-like spectrum, a coupler 102, an interferometer 103, a photodetector 104, a peak time acquisition unit 1106, and a resampling unit. 107 and a Fourier transform unit 108. Further, the interferometer 103 includes a balance photodetector 1031, a circulator 1032, a coupler 1033, a fiber collimator 1038, a mirror 1035, a fiber collimator 1039, and an optical deflector 1037. Each component in the figure is connected by an optical fiber (double line) or an electric cable (single line). The optical path from the coupler 1033 through the fiber collimator 1038 to the mirror 1035 is referred to as a reference arm 1034, and the optical path from the coupler 1033 through the fiber collimator 1039 and the optical deflector 1037 to the reflecting surface B in the observation object O. The sample arm 1036 will be called. The optical path from the fiber collimator 1038 to the mirror 1034 in the reference arm 1034 and from the fiber collimator 1039 in the sample arm 1036 to the reflecting surface B via the optical deflector 1037 is a spatial system, and is in space (usually Light propagates in the air.

  The light source 101 is a light source that performs wavelength sweeping so as to have a comb-shaped spectrum as described above. To realize this, the laser resonator has a predetermined free spectral range (FSR) in the laser resonator. A filter (a filter having a comb-shaped spectrum transmittance: a comb-tooth filter) is included. In a laser in which such a filter is inserted in the laser resonator, the output light intensity changes according to the transmittance of the filter. For example, when the filter has a light frequency at which the transmittance is maximum / minimum, the output light intensity is maximum / minimum. For this reason, when the resonance frequency of the laser resonator light is continuously changed over time, the output light intensity changes according to the frequency of the resonating light. ), The spectrum of the light source 101 has a comb shape having peaks at the intervals of FSR.

  In SS-OCT, the coherence length of the light source determines the depth (depth depth) that can be observed in the tomographic image obtained by SS-OCT, and if the coherence length is long, the depth depth becomes long. For this reason, it is important in SS-OCT that the light source has a long coherence length.

  It is known that the laser in which the comb filter shown above is inserted into a resonator has a maximum filter transmittance, that is, the coherence length of output light having a wavelength at which the laser output is maximized. Therefore, if only the output of the interferometer obtained by the light having a strong light source light intensity, that is, the light having a long coherence length is extracted and signal-processed, observation with a long depth can be performed. The method described below is a method of performing the above extraction, and is a method of sampling the output of the interferometer 103 with the peak value of intensity modulation of the output light of the light source light 101.

  The light source 101 outputs light whose wavelength is periodically swept. The light intensity changes with time according to the transmittance of the comb filter inserted in the laser resonator and the resonance frequency of the laser resonator. The interval between the maximum values (peak values) of the light intensity is the positive peak interval of cos (2hk (t)) where time is t, the wave number of the light source output light is k (t), and h is a constant. The same. The value of h is designed by information about the deepest position to be observed in the observation target, which will be described later.

  Output light from the light source 101 is branched by the coupler 102. One light emitted from the coupler 102 enters the interferometer 103, passes through the circulator 1032, is divided into two by the coupler 1033, and enters the reference arm 1034 and the sample arm 1036. The reference arm 1034 is reflected by the mirror 1035. The sample arm 1036 is reflected by the reflection surface in the object O to be observed. The light returned from the reference arm 1034 and the sample arm 1036 enters the coupler 1033 again and is combined to become interference light (fringe light). One of the interference light (fringe light) passes through the circulator 1032, and the other is directly input to the balance photodetector 1031 for photoelectric conversion, and the fringe signal which is an electric signal generated thereby is input to the resampling unit 107.

The optical path length difference z between the reference arm 1034 and the sample arm 1036 is an optical path length difference determined by the distance between the reference plane A that is the position of the mirror in the reference arm and the reflecting surface B in the object O. The fringe signal includes a signal component having a frequency proportional to the optical path length difference z. For example, when the wave number of the output light of the light source 101 is expressed by a function k (t) where time is t, the fringe signal includes a signal of cos (2zk (t)). That is, at time t, a signal having a frequency zk ′ (t) / π is included. Here, k ′ (t) is a function obtained by time-differentiating k (t), and k ′ (t) = dk / dt. In general, the reflection surface B in the object O is not limited to one and may be plural. For example, if there are N reflecting surfaces z ₁ ,..., Z _N , the fringe signal is expressed as N components of cos (2z ₁ k (t)),..., Cos (2z _N k (t)). Will have.

  The other light emitted from the coupler 102 is photoelectrically converted by the photodetector 104 and passed to the peak time acquisition unit 1106. The peak time acquisition unit 1106 measures the peak time of the input electric signal and outputs it to the resampling unit 107.

  FIG. 2 shows a procedure for processing electrical signals output from the photodetector 104 and the interferometer 103 in the SS-OCT system having the configuration shown in FIG.

  The peak time acquisition method described in Non-Patent Document 1 applies a low-pass filter after up-sampling peak detection target data (electric signal output from the photodetector 104), and removes high-frequency noise to up-sample. The peak time is acquired with the time accuracy of the sampling interval (S-1201).

  The resampling unit 107 samples the fringe signal input from the balance photodetector 1031 according to the peak time input from the peak time acquisition unit 106 and outputs the sampled signal to the Fourier transform unit 108. (S-1220) The Fourier transform unit 108 performs Fourier transform on the sampling signal of the fringe signal input from the resampling unit 107 and outputs the result. (S-1203)

  The resampling unit 107 temporally expands and contracts the fringe signal so that the component of cos (2zk (t)) included in the fringe signal becomes cos (2z (Δk / ΔT) t). Here, Δk is a sweep wave number width of the light source, and ΔT is a time for sweeping by Δk. The fringe signal before resampling includes a frequency represented by zk ′ (t) / π, and if k ′ (t) is not linear with respect to t (if it is not a linear function of t), the frequency varies with time. change. Resampling is to temporally expand and contract the fringe signal so that the fringe signal becomes a signal having a frequency that does not vary with time, such as z (Δk / ΔT) t / π. This is obtained by sampling the fringe signal at the peak time using the property that the time when the output light of the light source 101 reaches the peak is the positive peak of cos (2hk (t)). At this time, the resampling converts the fringe signal so that the time variation of k is linear with respect to time, such that Δk / ΔT per time. The fact that k is linear with respect to time is called wave number linear.

H that determines the period of intensity modulation of the output light of the light source 101 is determined by the optical path length difference z _max between the reference arm 1034 and the sample arm 1036 at the deepest position to be observed in the observation target. The resampling unit 107 samples the fringe signal at the peak time of the intensity of the output light from the light source 101. The frequency at the time t of the intensity modulation of the fringe light with respect to z is zk ′ (t) / π, and the light source output light In order to obtain all the fringe signals cos (2zk (t)) (where 0 ≦ z ≦ z _max ) where z is from 0 to z _max , it is hk ′ (t) / π. Based on the sampling theorem, the sampling frequency is determined to be at least twice the frequency of z _max , that is, 2z _max k ′ (t) / π ≦ hk ′ (t) / π, that is, 2z ≦ h. . Regarding how to realize h of the light source, for example, in Non-Patent Document 1, the FSR of a fiber Fabry-Perot filter (FFPF) in a fiber laser is c / (2h). There is an example designed. Here, c is the speed of light.

  The signal output from the Fourier transform unit 108 is a scan signal in the depth direction of SS-OCT, and this depth signal scan is referred to as A scan. Also, this scan signal is called an A scan signal. The A-scan does not mean physical light operation such as deflecting with an optical deflector or the like, but means obtaining depth direction information by Fourier-transforming the fringe signal as described above.

  Since the A scan signal is a Fourier transform of the resampled fringe signal, it is a signal indicating the intensity with respect to the frequency, but the frequency f can be converted to a distance z in the depth direction, and their relationship is z = πf / k ′. It is expressed. Here, k ′ is ideally k ′ = Δk / ΔT in the A-scan signal after resampling, and therefore z = πfΔT / Δk after resampling.

The reflection surface in the object O to be observed is represented by the signal intensity in the A scan signal, but on the A scan signal, a signal having a frequency corresponding to the position where the reflection surface is located becomes strong. When there are a plurality of reflection surfaces, the fringe signal includes a component signal corresponding to the reflection surface and corresponding to the difference in optical path length between the reference arm and the sample arm. For example, there are N of the reflection point, the optical path length difference _z 1 corresponding to them, ..., if it was _{z N,} the fringe signal _{cos (2z 1 k (t)} ), ..., cos (2z N N components of k (t)) are included. Similarly, the resampled fringe signal includes N components of cos (2z ₁ Δk / ΔTt),..., Cos (2z _N Δk / ΔTt), and their frequencies are f ₁ = z ₁ Δk / ( πΔT),..., f _N = z _N Δk / (πΔT). When the resampled fringe signal is Fourier-transformed, a signal having a high intensity at a frequency position corresponding to f ₁ ,..., F _N appears in accordance with the reflection intensity in the object O to be observed. When these frequencies are converted into z = πfΔT / Δk, the correspondence between the depth distance and the reflection intensity can be taken.

  When there is only one reflecting surface in the object O to be observed and the reflecting surface is at a position corresponding to the optical path length difference z between the reference light and the sample light at this time, it corresponds to z of the A scan signal. It is desirable that the signal at the location, that is, the frequency f = z (Δk / ΔT) / π is strong, and the signal at the other frequency is 0 (delta function). Such an A-scan signal obtained from a fringe signal in the case of having one reflection point is called a point spread function (PSF). However, due to modulation of the light source light intensity within ΔT, optical and electrical noise, inadequate signal processing such as resampling, etc., the actual PSF does not become a delta function, and half of the PSF. The value range becomes large, and the SNR (PSF peak / noise floor level) becomes low (bad).

  Resampling is a process that makes a wavenumber linear that is not wavenumber linear, but if there is an error in the sampling time (if accurate resampling is not possible), an accurate wavenumber fringe signal is generated. The half width of the PSF becomes large, and the SNR of the PSF deteriorates.

Tsung-Han Tsia, Chao Zhoua, Desmond Adlera, and James G. Fujimoto, “Frequency Comb Swept Lasers for Optical Coherence Tomography,” Proc. of SPIE, Vol. 7554, pp. 7554E-1-10 (2010).

  Since the output light of the light source 101 is divided by the coupler 102, the light irradiated to the object from the interferometer 103 becomes weak. When the light applied to the object is weakened, the light reflected from the object is also weakened, and the interference light received by the balance photodetector 1031 in the interferometer 103 is also weakened. Therefore, it is easy to be affected by optical noise generated from the light source 101 to the balance photo detector 1031 in the interferometer 103, and the influence of electrical noise generated after the balance photo detector in the interferometer 103 or after the photo detector 104. For this reason, the SNR of the A scan signal output from the Fourier transform unit 108 tends to deteriorate.

  Since the coupler 102 and the subsequent optical paths pass through different optical paths, the peak time acquired by the peak time acquisition unit is affected by the optical delay due to the wavelength dispersion of the optical path and the optical path length difference, and the peak time acquired from the interferometer 103 is transferred to the resampling unit 107. It will not match the input fringe signal. That is, the peak time detection accuracy is degraded. When the peak time detection accuracy is low, it is difficult to perform accurate resampling in the subsequent processing. Therefore, only the fringe signal obtained by causing the interferometer 103 to interfere with light having a long coherence length of the output light of the light source 101 is extracted. Becomes difficult. As a result, there is a problem that the depth of the A scan signal does not become long, that is, the tomographic image cannot be seen deeply. Further, due to the same cause, there is a problem that the half-value width of the PSF of the A scan signal output from the Fourier transform unit 108 is likely to be large, and a problem that the SNR is likely to be deteriorated.

  The present invention has been made in view of the above-described conventional problems, and an object of the present invention is to provide an optical coherence tomography apparatus that reduces the SNR and the deviation from the wave number sweep.

  In order to solve the above problems, the invention described in one embodiment includes a light source that sweeps a wavelength so as to have a comb-shaped spectrum, and light output from the light source is incident on an object to be observed. An interferometer that outputs a fringe signal that is an interference signal corresponding to the structure of the object to be observed, and a high-pass filter that separates a signal having an intensity modulation frequency component of the light source from the fringe signal output from the interferometer A peak time acquisition unit that acquires a peak time that is a time at which a peak of the signal separated by the high-pass filter unit appears, and a resampling unit that samples a fringe signal at the peak time. It is a tomographic device.

It is a figure which shows the structural example of the conventional SS-OCT system. It is a figure which shows the processing flow of the signal output from the photodetector of the SS-OCT system of FIG. It is a figure which shows the structural example of the SS-OCT system of 1st Embodiment. It is a figure which shows the structural example of the light source comprised by the spatial optical system. It is a figure which shows the processing flow of the signal output from the photodetector of the apparatus of FIG.

  Hereinafter, embodiments of the present invention will be described in detail. The optical coherence tomography apparatus of the present invention includes a light source that sweeps a wavelength so as to have a comb-shaped spectrum, and an interference according to the structure of the object to be observed by making the light output from the light source incident on the object to be observed. An interferometer that outputs a fringe signal that is a signal; a high-pass filter that separates a fundamental component of the intensity modulation frequency of the light source and a signal of its harmonic component from the fringe signal output from the interferometer; and the high-pass filter A peak time acquisition unit that acquires a peak time that is a time at which a peak of the signal separated by the unit appears, and a resampling unit that samples a fringe signal at the peak time.

In the optical coherence tomography apparatus, the cut-off frequency f _c of the high-pass filter unit is ν _s / 2 ≦ f _c <ν _{s with} respect to the temporal intensity modulation frequency ν _s of the comb-shaped spectral wavelength swept light source. Is preferably set.

  According to the optical coherence tomography apparatus, since all the output light from the light source can be put into the interferometer, the intensity of light incident on the object from the interferometer becomes stronger than before, so that the SNR of the fringe can be prevented from decreasing.

  In addition, since the optical path for acquiring the peak time and the optical path for acquiring the fringe signal can be the same (interferometer 103), accurate resampling is possible. This makes it possible to accurately sample the interference signal of light with a long coherence length that appears at the peak time of the output light intensity of the light source, and to increase the depth of the tomographic image, that is, to deepen the object to be observed. It becomes possible to observe up to.

  In addition, as described above, since accurate resampling is possible, the fringe signal output from the resampling unit is the same as the fringe signal when the light source is accurately swept in a wavenumber linear form. Since the half width of the PSF of the output A scan signal becomes narrower and the SNR becomes larger, the sharpness becomes higher.

(First embodiment)
The optical coherence tomography apparatus according to the first embodiment will be described. FIG. 3 is a diagram illustrating a configuration example of the SS-OCT system according to the first embodiment. As shown in FIG. 3, the SS-OCT system of the present embodiment includes a light source 101 that performs wavelength sweep so as to obtain a comb-shaped spectrum, an interferometer 103, a high-pass filter unit 105, and a peak time acquisition unit 106. A resampling unit 107 and a Fourier transform unit 108. Further, the interferometer 103 includes a balance photodetector 1031, a circulator 1032, a coupler 1033, a fiber collimator 1038, a mirror 1035, a fiber collimator 1039, and an optical deflector 1037. The optical path from the coupler 1033 through the fiber collimator 1038 to the mirror 1035 is a reference arm 1034, and the optical path from the coupler 1033 through the fiber collimator 1039 and the optical deflector 1037 to the reflecting surface B in the observation object O is the sample arm. 1036. Each component in the figure is connected by an optical fiber (double line) or an electric cable (single line).

  In the optical coherence tomography apparatus according to the present embodiment, the optical path for acquiring the peak time is the same as the optical path for acquiring the fringe signal. The time acquisition and fringe signal acquisition are the same, and resampling is performed accurately. This makes it possible to accurately sample the interference signal of light with a long coherence length that appears at the peak time of the output light intensity of the light source, and to increase the depth of the tomographic image, that is, to deepen the object to be observed. It becomes possible to observe up to. In addition, since accurate resampling is possible as described above, the fringe signal output from the resampling unit 107 is obtained when the light source 101 sweeps the wave number of light accurately and linearly with respect to time (in the case where the wave number is linear). ), The half width of the PSF of the A scan signal output from the Fourier transform unit 108 is narrowed, and the SNR is increased, so that the sharpness is increased.

  The light source 101 is a laser whose wavelength (frequency) of light changes (sweeps) with time, and the peak of its oscillation spectrum takes discrete values at regular intervals with respect to the frequency. A spectrum obtained by superimposing the oscillation spectrum for one sweep (a time integral of one sweep) is a comb-shaped spectrum having peaks at equal intervals with respect to the frequency. Since the frequency of the light source 101 changes with time, the laser oscillation repeatedly increases and decreases with time. That is, the intensity of the output light from the light source 101 is modulated. This intensity modulation has a fundamental component of cos (2hk (t)) and its harmonic component. Here, cos (x) is the cosine of x, h is a constant, k (t) is the wave number of light, and changes with time t. This h is a parameter of the optical component in the laser resonator in the light source, and is a constant determined based on the maximum depth of the object to be measured.

  In the light source 101 whose intensity modulation is cos (2hk (t)), the frequency interval (free spectral interval: FSR) between adjacent comb teeth spectrum generated by the light source 101 is c / (2h). Light source. Here, c is the speed of light. As a configuration of the light source 101, there are a fiber laser in which a fiber Fabry-Perot filter (FFPF) is inserted, and an etalon inserted in a laser resonator constituted by a spatial optical system. The FFPF or etalon at this time uses a light source having an FSR of c / (2h), thereby realizing a light source having an FSR of c / (2h).

  FIG. 4 shows a configuration example of the light source 1 configured by a spatial optical system. The configuration shown in FIG. 4 is a Littman-Metcalf type resonator composed of a spatial optical system. Light emitted from a semiconductor optical amplifier (SOA) 304 is collimated by a collimator lens 306 and then etalon 307. Then, the light is deflected by the optical deflector 308 and incident on the diffraction grating 310, and the diffracted light is sent to the mirror 311. Only the light that is perpendicularly incident on the mirror 311 returns to the SOA 304 along the reverse path, is folded back at the SOA reflecting surface 305, and finally laser-resonates between the SOA reflecting surface 305 and the mirror 311. The SOA reflecting surface 305 is a half mirror, and part of the laser-oscillated light passes through the SOA reflecting surface, reaches the optical fiber 301 via the coupling lens 303 and the isolator 302, and is output to the outside of the resonator. An etalon having an optical path length of h is used. For example, when the refractive index of the etalon is n and the thickness of the etalon is d, h = nd. Since the resonance frequency of the light of the laser resonator varies depending on the incident angle from the optical deflector 308 to the diffraction grating 310, the angle (deflection angle) of the light emitted from the optical deflector 308 by the optical deflector controller 309 is changed over time. Therefore, the frequency of the output light from the light source 101 is continuously changed (swept).

  In the interferometer 103 to which light from the light source 1 is input, the input light is input to the coupler 1033 via the circulator 1032, branched into two by the coupler 1033, and then input to the reference arm 1034 and the sample arm 1036. One light branched by the coupler 1033 is reflected by the mirror 1035 provided at the reference position A of the reference arm 1034 and returns to the coupler 1033 again. The other light branched by the coupler 1033 is reflected by the reflection surface B in the object O to be observed (the reflection surface B is not necessarily one place in the object) and returns to the coupler 1033 again. Each time the light source sweeps one time, the position where the A-scan is performed in the width direction W by the optical deflector 1037 is gradually moved. In this way, the operation of continuously changing the position where light is physically applied to the observation target (the position where the A scan is performed) is called B scan.

  In the coupler 1033, the two return lights from the reference arm 1034 and the sample arm 1036 are combined and interfered. That is, the coupler 1033 functions as an interference mechanism. Interfering light (fringe light) generated from these two return lights is branched into two with their phases inverted, and one enters the balance photodetector 1031 directly through the circulator 1032. The balance photodetector 1031 converts each incident light into an electrical signal and outputs the difference signal to the resampling unit 107. This output signal is called an interference signal (fringe signal).

The fringe signal (electric signal) output from the interferometer 103 is a signal that changes according to the optical path length difference z between the reference arm and the sample arm. Specifically, the fringe signal has a component of cos (2zk (t)). Since the output light from the light source 101 is intensity-modulated by cos (2hk (t)), the fringe signal has two basic components represented by cos (2zk (t)) and cos (2hk (t)). And its harmonic components. Assuming that z _max is the deepest position z from the reference plane A of the reflecting surface in the object O to be observed, h determines the frequency of intensity modulation of the light source 101, and determines the time interval for resampling is 2z _max. The above is satisfied (h ≧ 2z _max ). The reason for this is based on the following principle. The fringe signal for z is modulated by cos (2zk (t)), and the frequency ν _f (t) at time t is zk ′ (t) / π. However, k ′ (t) is a differentiated function of k (t) at time t, and k ′ (t) = dk / dt. On the other hand, the light output of the light source 101 is modulated by cos (2hk (t)), and the frequency ν _s (t) at time t is hk ′ (t) / π. Since the fringe signal is sampled at the peak time of the light output of the light source 101, the fringe signal is sampled at a sampling frequency represented by hk ′ (t) / π around time t. Since the highest frequency of the fringes due to reflection points in the object O to be observed is the z frequency of the interference light generated by the light from the _max become reflection point _{z max k '(t) /} π, the information of the signal component of the frequency In order to obtain all of the above, from the sampling theorem, it is necessary that 2z _max k ′ (t) / π ≦ hk ′ (t) / π. Therefore, h is set to be 2z _max or more (where h ≧ 2z _max ).

Here, the relationship between ν _s and z _max and the free spectral interval (FSR) between the comb teeth of the comb-shaped spectrum of the light from the light source 101 will be described. Since FSR = c / (2h) (or h = c / (2FSR)), the component of the light intensity modulation signal of the light source 101 is cos (ck (t) / FSR) and its harmonics. Its frequency ν _{s at} t is (c / (2πFSR)) · k ′ (t). However, k ′ (t) is a function obtained by differentiating k (t) by t, and k ′ (t) = dk (t) / dt. Further, since h ≧ 2z _max , c / (4FSR) ≧ z _max (or FSR ≦ c / (4z _max )).

  FIG. 5 shows a processing procedure of the electrical signal output from the interferometer 103 by the high-pass filter unit 105, the peak time acquisition unit 106, the resampling unit 107, and the Fourier transform unit 108.

First, the high-pass filter 105 separates the intensity modulation frequency component of the light source 101, that is, the fundamental component of cos (2hk (t)) and its harmonic component signal from the input fringe signal. Separating a predetermined frequency component by cut-off frequency _{f c} of the (S-201) the high-pass filter 105. Here will be described below cut-off frequency f _c of the for separating fundamental component and harmonic components thereof cos (2hk (t)) from the fringe signal. The frequencies ν _s and ν _f at t = t ₀ of each component of cos (2hk (t)) and cos (2zk (t)) included in the fringe signal are respectively

It becomes. Here, “||” represents an absolute value. As described above, since h> 2z _max ≧ 2z, ν _s > 2ν _f (that is, ν _s / 2> ν _f ) is always satisfied. If the cut-off frequency f _c of the high-pass filter is ν _f ≦ f _c <ν _s , only the signal ν _s can be separated from the fringe signal. However, as described above, always ν _s / 2> ν _f . since, by using a high-pass filter with a [nu _s / 2 or more cut in less than [nu _s-off frequency _{f c} (i.e., the _{ν s / 2 ≦ f c <} ν s f c), cos (2hk ( Only component t)) can be separated from the fringe.

By the way, when dk (t) / dt does not become a constant with respect to time t (that is, when dk (t) / dt fluctuates over time), the frequencies ν _s and ν _{f of the} signal included in the fringe signal are As can be seen from the equation, it varies with time. Due to this time variation, when a high-pass filter with f _c fixed in time is used, depending on the function representing k (t), the time when f _c > ν _s and f _c <ν _f are satisfied. Time may occur. That is, when a high-pass filter having a fixed f _c with respect to time is used, only the component of cos (2hk (t)) cannot be separated from the fringe in the time zone of f _c > ν _s , while f _c In the time zone of <ν _f , a signal in which a component of cos (2hk (t)) and a component of cos (2zk (t)) are mixed is output from the high-pass filter. Thus, the filter cut-off frequency f _c is not changed temporally may not be used. In that case, a dynamic filter that temporally varies the cutoff frequency may be used.

For example, in the case of a digital filter, the dynamic filter is one that fluctuates the coefficient of the filter over time. In the case of an analog filter, the resistance value of the resistor constituting the circuit, the capacitance value of the capacitor, and the inductance of the inductor are temporally varied. For example, if you use a varicap, by temporally varying the voltage applied to the varicap, it is possible to vary the capacitance in time, it is possible to vary the f _c of the high-pass filter time.

Specifically, the cut-off frequency f _c of the high-pass filter used ν _f ≦ _{f c <ν s} temporally varied so. Further, since the relationship between [nu _s and [nu _f is the above as described in the ν _{s /} 2> ν _f, regardless of cut-off frequency f _c of the high-pass filter used in the time variation of the [nu _s and [nu _f What is necessary is just to change temporally so that it may always satisfy (nu) _s / 2 <= _fc <(nu) _s .

Assuming that the deepest z to be measured of the object O is z _max , the optical path length h of the etalon is designed to be 2z _max or more (that is, h ≧ 2z _max ) as described above, so ν _s and ν _f are Each is determined according to the above formula. That is, when z _max is determined, ν _s and ν _f for a certain time are determined. Therefore, the cutoff frequency f _c of the high-pass filter may be determined as ν _f ≦ f _c <ν _s (or ν _s ≦≦ f _c <ν _s ) for a certain time as described above. down during operation of the optical coherence tomography apparatus, it is not necessary to calculate the cut-off frequency f _c by measuring the [nu _s and [nu _f of the output signal from the light source 1 and the interferometer 3. That, z _max and once you decide h that matches it, since the range of the cut-off frequency f _c for a time determined, cut-off frequency f _c of the each time before operating the optical coherence tomography apparatus of the present embodiment the calculated in advance, during the operation of the optical coherence tomography apparatus of the present embodiment, the cutoff frequency for that time, to operate the high-pass filter such that the cut-off frequency f _c of the calculated. Alternatively, if the function of the wave number k (t) of the light source light with respect to time is known, the function of ν _s (t) is also known, so that the cutoff frequency f is real-time during the operation of the optical coherence tomography apparatus of the present embodiment. _c is calculated and the high-pass filter is operated. The signal separated by the high-pass filter unit 105 in this way includes a fundamental component of cos (2hk (t)) that is the intensity modulation frequency of the output signal of the light source 101 and a signal of its harmonic component.

  The peak time acquisition unit 106 detects the peak of the signal separated by the high-pass filter unit 105, obtains the time at which the peak appears, and outputs it to the sampling unit 107. (S-202)

  The resampling unit 107 samples the fringe signal output from the interferometer 103 at the peak time acquired by the peak time acquisition unit 106. (S-203)

  The Fourier transform unit 108 performs a Fourier transform on the fringe signal sampled by the resampling unit 107. The signal after the Fourier transform becomes an A-scan signal of the SS-OCT system. (S-204)

  According to the optical coherence tomography apparatus described above, since all the output light from the light source can be put into the interferometer, the light intensity incident on the object from the interferometer becomes stronger than before, so that the SNR of the fringe can be prevented from decreasing. In addition, since the optical path for acquiring the peak time and the optical path for acquiring the fringe signal can be the same (interferometer 103), accurate sampling can be performed.

DESCRIPTION OF SYMBOLS 101 Light source 102 Coupler 103 Interferometer 1031 Balanced photo detector 1032 Circulator 1033 Coupler 1034 Reference arm 1035 Mirror 1036 Sample arm 1037 Optical deflector 1038 Fiber collimator 1039 Fiber collimator 105 High pass filter unit 106 Peak time acquisition unit 107 Resampling unit 301 Fourier transform unit Optical fiber 302 Isolator 303 Coupled lens 304 SOA
305 SOA reflecting surface 306 Collimator lens 307 Etalon 308 Optical deflector 309 Optical deflector controller 310 Diffraction grating 311 Mirror

Claims (8)

A light source that sweeps the wavelength so that it has a comb-shaped spectrum;
An interferometer that inputs light output from the light source to an object to be observed and outputs a fringe signal that is an interference signal according to the structure of the object to be observed;
A high-pass filter for separating a signal having a component of an intensity modulation frequency of the light source from a fringe signal output from the interferometer;
A peak time acquisition unit that acquires a peak time that is a time at which a peak of the signal separated by the high-pass filter unit appears;
An optical coherence tomography apparatus comprising: a resampling unit that samples a fringe signal at the peak time. Cut-off frequency f _c of the said high-pass filter unit, to the temporal intensity modulation frequency [nu _s of the light source, to claim 1, characterized in that it is set as _{ν s / 2 ≦ f c <} ν s The optical coherence tomography apparatus described. The high-pass filter unit, a varying the cut-off frequency f _c to satisfy even _{ν s / 2 ≦ f c <} ν s if there is a time variation of the wave number of the light output temporally from said light source The optical coherence tomography apparatus according to claim 1 or 2, characterized in that Ν _s is the wave number of light output from the light source k (t), the time derivative of k (t) is k ′ (t), the free spectral interval of the spectrum of the light output from the light source is FSR, The optical coherence tomography apparatus according to claim 1, wherein ν _s = (c / (2πFSR)) · k ′ (t), where c is a high speed. The constant FSR is determined so that FSR ≦ c / (4z _max ), where z _max is a value when the optical path length difference between the reference arm and the sample arm is longest in the object to be observed. The optical coherence tomography apparatus according to claim 4.   The interferometer splits the input light into two, inputs one light to the reference arm and reflects it with a mirror arranged at the standard position, and inputs the other light to the sample arm and inputs the observation target. 2. An interference mechanism that generates interference light by combining light reflected by a reflecting surface in an object, and a photodetector that converts the interference light into an electrical signal and outputs the electrical signal. The optical coherence tomography apparatus according to any one of 5.   The light source is a laser, a comb-type filter is inserted in an optical path in a laser resonator, and the FSR of the comb-type filter is an interval between comb teeth of the comb-type spectrum of the light source. The optical coherence tomography apparatus according to any one of claims 1 to 6. The comb filter is an etalon, and the optical path length h of the etalon is h _max when the _maximum optical path length difference between the reference arm and the sample arm is z _{max in} the object to be observed. The optical coherence tomography apparatus according to claim 7, wherein the optical coherence tomography apparatus is determined to satisfy ≧ 2z _max .

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