JP6141958B2 - 増殖性疾患の治療のための併用療法（ベムラフェニブ及びｍｄｍ２阻害剤） - Google Patents

増殖性疾患の治療のための併用療法（ベムラフェニブ及びｍｄｍ２阻害剤） Download PDF

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JP6141958B2
JP6141958B2 JP2015500865A JP2015500865A JP6141958B2 JP 6141958 B2 JP6141958 B2 JP 6141958B2 JP 2015500865 A JP2015500865 A JP 2015500865A JP 2015500865 A JP2015500865 A JP 2015500865A JP 6141958 B2 JP6141958 B2 JP 6141958B2
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cancer
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JP2015510908A (ja
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ブライアン ヒギンス，
ブライアン ヒギンス，
ケネス コリーンスキー，
ケネス コリーンスキー，
グウェン ニコルズ，
グウェン ニコルズ，
キャスリン イー． パックマン，
キャスリン イー． パックマン，
フェイ スー，
フェイ スー，
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エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015500865A 2012-03-19 2013-03-18 増殖性疾患の治療のための併用療法（ベムラフェニブ及びｍｄｍ２阻害剤） Active JP6141958B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261612441P 2012-03-19 2012-03-19
US61/612,441 2012-03-19
PCT/EP2013/055522 WO2013139724A1 (en) 2012-03-19 2013-03-18 Combination therapy (vemrufenib and a mdm2 inhibitor) for the treatment proliferative disorders

Publications (2)

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JP2015510908A JP2015510908A (ja) 2015-04-13
JP6141958B2 true JP6141958B2 (ja) 2017-06-07

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JP2015500865A Active JP6141958B2 (ja) 2012-03-19 2013-03-18 増殖性疾患の治療のための併用療法（ベムラフェニブ及びｍｄｍ２阻害剤）

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US (2) US9216170B2 (enrdf_load_stackoverflow)
EP (1) EP2827859B1 (enrdf_load_stackoverflow)
JP (1) JP6141958B2 (enrdf_load_stackoverflow)
KR (1) KR101673731B1 (enrdf_load_stackoverflow)
CN (2) CN108295063A (enrdf_load_stackoverflow)
AR (1) AR090349A1 (enrdf_load_stackoverflow)
AU (1) AU2013203637B2 (enrdf_load_stackoverflow)
BR (1) BR112014018910A8 (enrdf_load_stackoverflow)
CA (1) CA2861056A1 (enrdf_load_stackoverflow)
HK (1) HK1201198A1 (enrdf_load_stackoverflow)
MX (1) MX2014010590A (enrdf_load_stackoverflow)
NZ (1) NZ626985A (enrdf_load_stackoverflow)
RU (1) RU2014141362A (enrdf_load_stackoverflow)
SG (1) SG11201404418QA (enrdf_load_stackoverflow)
WO (1) WO2013139724A1 (enrdf_load_stackoverflow)
ZA (1) ZA201405411B (enrdf_load_stackoverflow)

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US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
WO2012021876A2 (en) 2010-08-13 2012-02-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8709419B2 (en) 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
US9295669B2 (en) 2010-12-14 2016-03-29 Hoffman La-Roche Inc. Combination therapy for proliferative disorders
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
US20140200255A1 (en) 2012-03-19 2014-07-17 Brian Higgins Method for administration
US9216170B2 (en) 2012-03-19 2015-12-22 Hoffmann-La Roche Inc. Combination therapy for proliferative disorders
US20130245089A1 (en) 2012-03-19 2013-09-19 Hoffmann-La Roche Inc. Method for administration
PL2884979T3 (pl) 2012-08-17 2019-11-29 Hoffmann La Roche Terapie skojarzone czerniaka obejmujące podawanie kobimetynibu i wemurafinibu
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
AU2014346354A1 (en) 2013-11-11 2016-05-26 Amgen Inc. Combination therapy including an MDM2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers
WO2015084804A1 (en) 2013-12-03 2015-06-11 Novartis Ag Combination of mdm2 inhibitor and braf inhibitor and their use
WO2015082384A1 (en) * 2013-12-05 2015-06-11 F. Hoffmann-La Roche Ag Novel combination treatment for acute myeloid leukemia (aml)
MX2016013439A (es) * 2014-04-15 2016-11-17 Hoffmann La Roche Formas solidas de un compuesto farmaceuticamente activo.
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EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
KR102570210B1 (ko) 2014-09-24 2023-08-23 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 제제
WO2016106357A1 (en) * 2014-12-23 2016-06-30 Millennnium Pharmaceuticals, Inc. Combination of raf inhibitors and aurora kinase inhibitors
EP3260119B1 (en) 2015-02-20 2023-11-15 Daiichi Sankyo Company, Limited Combination method for treating cancer
BR112017019738A2 (pt) 2015-03-20 2018-05-29 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
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CN110291089B (zh) 2017-01-17 2022-05-27 海帕瑞吉尼克斯股份有限公司 用于促进肝再生或者减少或预防肝细胞死亡的蛋白激酶抑制剂
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN110585433A (zh) * 2019-09-27 2019-12-20 青岛大学 Braf-v600e的抑制剂的应用及用于治疗甲状腺癌的药物

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Also Published As

Publication number Publication date
JP2015510908A (ja) 2015-04-13
CN108295063A (zh) 2018-07-20
WO2013139724A1 (en) 2013-09-26
BR112014018910A8 (pt) 2017-07-11
AU2013203637B2 (en) 2016-07-07
SG11201404418QA (en) 2014-10-30
AU2013203637A1 (en) 2013-10-03
EP2827859A1 (en) 2015-01-28
US9216170B2 (en) 2015-12-22
KR101673731B1 (ko) 2016-11-07
MX2014010590A (es) 2014-09-18
BR112014018910A2 (enrdf_load_stackoverflow) 2017-06-20
US9486445B2 (en) 2016-11-08
CN104114168A (zh) 2014-10-22
US20160051525A1 (en) 2016-02-25
KR20140130179A (ko) 2014-11-07
AR090349A1 (es) 2014-11-05
US20130245039A1 (en) 2013-09-19
NZ626985A (en) 2016-07-29
CA2861056A1 (en) 2013-09-26
ZA201405411B (en) 2019-09-25
EP2827859B1 (en) 2018-10-17
HK1201198A1 (en) 2015-08-28
RU2014141362A (ru) 2016-05-10

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