JP6132680B2 - 予充填可能薬剤送達装置 - Google Patents
予充填可能薬剤送達装置 Download PDFInfo
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- JP6132680B2 JP6132680B2 JP2013131938A JP2013131938A JP6132680B2 JP 6132680 B2 JP6132680 B2 JP 6132680B2 JP 2013131938 A JP2013131938 A JP 2013131938A JP 2013131938 A JP2013131938 A JP 2013131938A JP 6132680 B2 JP6132680 B2 JP 6132680B2
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- 239000007924 injection Substances 0.000 description 8
- 229920001971 elastomer Polymers 0.000 description 6
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- 230000006378 damage Effects 0.000 description 3
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- 210000003462 vein Anatomy 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
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- 239000012141 concentrate Substances 0.000 description 1
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
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- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
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- A—HUMAN NECESSITIES
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- A61M5/283—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
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- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
- A61M2005/3261—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user triggered by radial deflection of the anchoring parts between sleeve and syringe barrel, e.g. spreading of sleeve retaining hooks having slanted surfaces by engagement with conically shaped collet of the piston rod during the last portion of the injection stroke of the plunger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
- A61M2005/3261—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user triggered by radial deflection of the anchoring parts between sleeve and syringe barrel, e.g. spreading of sleeve retaining hooks having slanted surfaces by engagement with conically shaped collet of the piston rod during the last portion of the injection stroke of the plunger
- A61M2005/3263—Trigger provided at the distal end, i.e. syringe end for mounting a needle
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
- F04C2270/00—Control; Monitoring or safety arrangements
- F04C2270/04—Force
- F04C2270/042—Force radial
- F04C2270/0421—Controlled or regulated
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- Health & Medical Sciences (AREA)
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- Vascular Medicine (AREA)
- Anesthesiology (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Environmental & Geological Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
ニードルハブを少なくとも部分的に受け入れるハウジングであって、前記ニードルハブの遠位端が前記ハウジングの遠位端を越えて延びる引込位置と、前記ニードルハブの遠位端が前記ハウジングの遠位端を越えない保護位置との間で前記ニードルハブに対して移動可能なハウジングと、
薬剤を受け入れるための管状筒であって、前記ニードルハブの少なくとも一部が前記管状筒の遠位端を実質的に閉鎖するように、その遠位端を介して前記ハウジングに予備組付け可能であり、前記縦軸に沿って、前記ニードルハブと前記ハウジングに対して並進および/または回転運動可能である管状筒と、
を備える予充填可能薬剤送達装置であり、
前記装置は、前記管状筒が前記ハウジングに予備組付けされたところで動作可能となる密封手段をさらに含み、前記密封手段は、前記ニードルハブの前記一部と前記管状筒の内壁とが密着しない無効状態から、前記ニードルハブの前記一部と前記管状筒の内壁とが密着する有効状態へと移動可能であり、
前記密封手段が有効状態にある時、前記管状筒は、管状筒に送達されるべき薬剤を充填できる充填位置と、前記充填位置に対して遠位側に離間され、おそらく前記管状筒内に受け入れられている前記薬剤が前記針を介して前記管状筒から実質的に押し出され切った送達完了時位置との間で前記ニードルハブに対して並進運動可能である。
2 針
2a 近位端
4 スリーブ
6 外側フランジ
7 薬剤
8 ストッパ
10 ハウジング
10b 遠位端
15 脚状片
15c 傾斜した近位面
15d 内側半径方向ペグ
16 内側半径方向凸部
16a 近位面
19 環状凹部
20 ニードルハブ
20b 遠位端
22 半径方向に圧縮可能な部分
27 円周方向の窓
30 管状筒
30a 近位端
30b 遠位端
31 狭小部分
33 円形外側縁部
Claims (18)
- ニードルハブ(20)を少なくとも部分的に受け入れるハウジング(10)であって、前記ニードルハブの遠位端(20b)が前記ハウジングの遠位端(10b)を越えて延びる引込位置と、前記ニードルハブの前記遠位端が前記ハウジングの前記遠位端を越えない保護位置との間で、前記ニードルハブに対して移動可能なハウジング(10)と、
薬剤(7)を受け入れる管状筒(30)であって、前記ニードルハブの少なくとも一部が前記管状筒の前記遠位端を実質的に閉鎖するように、その遠位端を介して前記ハウジングに予備組付け可能であり、縦軸に沿って、前記ニードルハブと前記ハウジングに対して並進および/または回転運動可能な管状筒(30)と、を備える予充填可能薬剤送達装置(1)において、
前記装置は、前記管状筒が前記ハウジングに予備組付けされると動作可能な密封手段(22、31)をさらに備え、前記密封手段は、前記ニードルハブの前記一部と前記管状筒の内壁とが密着しない無効状態から、前記ニードルハブの前記一部が前記管状筒の内壁と密着する有効状態へと移動可能であり、
前記密封手段の有効状態において、前記管状筒は前記ニードルハブに対して、送達されるべき薬剤を前記管状筒に充填できる充填位置と、前記充填位置に対して遠位方向に離間され、おそらく前記管状筒の中に受け入れられている前記薬剤が針を介して前記管状筒から実質的に押し出され切った送達完了位置との間で並進運動可能であることを特徴とする予充填可能薬剤送達装置(1)。 - 前記ハウジングが縦軸を有し、前記ニードルハブが針を支持し、前記ニードルハブと針が前記縦軸上で実質的に同心状であり、前記ハウジングがその引込位置にある時に前記針の遠位端(2b)が前記ハウジングの前記遠位端(10b)を越えて延び、前記ハウジングがその保護位置にある時に前記針の前記遠位端は前記ハウジングの前記遠位端を越えないことを特徴とする、請求項1に記載の予充填可能薬剤送達装置(1)。
- 前記密封手段を作動する前に、前記管状筒を前記ハウジング(10)に予備組付けされた状態に保持する一時的保持手段(19、33)をさらに備えることを特徴とする、請求項1または2に記載の予充填可能薬剤送達装置(1)。
- 前記密封手段は、前記ニードルハブに対する前記管状筒の限定的運動の影響によって、その無効状態からその有効状態へと移動されるように設計されることを特徴とする、請求項3に記載の予充填可能薬剤送達装置(1)。
- 前記一時的保持手段は、前記管状筒(30)の遠位部の外壁に位置付けられた外側縁部(33)と、前記ハウジングの内壁に位置付けられた環状凹部(19)を含み、前記管状筒が前記ハウジングに予備組付けされた時に、前記外側縁部は前記環状凹部と係合し、前記外側縁部は前記限定的運動の影響によって前記環状凹部から外れることを特徴とする、請求項4に記載の予充填可能薬剤送達装置(1)。
- 前記密封手段の一部(31)は前記管状筒上に位置付けられ、前記密封手段の別の部分(22)は前記ニードルハブ上に位置付けられることを特徴とする、請求項5に記載の予充填可能薬剤送達装置(1)。
- 前記密封手段がいったんその有効状態になると、それがその無効状態に戻るのを防止する固定手段(16、33)をさらに備えることを特徴とする、請求項6に記載の予充填可能薬剤送達装置(1)。
- 前記固定手段の一部(33)は前記管状筒上に位置付けられ、前記固定手段の他の部分(16)は前記ハウジング上に位置付けられることを特徴とする、請求項7に記載の予充填可能薬剤送達装置(1)。
- 前記密封手段は、前記ニードルハブ(20)の半径方向に圧縮可能な部分(22)と、前記管状筒(30)の内壁の狭小部分(31)を含み、前記ニードルハブに対する前記管状筒の遠位方向への限定的運動の影響によって、前記狭小部分が前記半径方向に圧縮可能な部分と対面させられると、前記密封手段がその有効状態に到達し、それによって前記狭小部分が前記半径方向に圧縮可能な部分を圧縮し、前記ニードルハブと前記管状筒の前記内壁とを密着させることを特徴とする、請求項7または8に記載の予充填可能薬剤送達装置(1)。
- 前記固定手段は、前記外側縁部(33)と、前記ハウジング(10)の前記内壁上の前記環状凹部(19)に対して遠位方向に離間された半径方向の凸部(16)を含み、前記半径方向の凸部には傾斜した近位面(16a)が設けられ、前記外側縁部は、前記ニードルハブに対する前記管状筒の前記遠位方向への限定的運動の影響を受けて、前記傾斜した近位面を乗り越えることができ、その後、前記密封手段はその有効状態にあり、近位方向への力が前記管状筒(30)に加えられると、前記外側縁部が前記半径方向の凸部と近位側から当接することを特徴とする、請求項8に記載の予充填可能薬剤送達装置(1)。
- 少なくとも前記管状筒がその送達完了位置に到達するまで、前記ハウジング(10)をその引込位置に保持するための保持手段(15、15d、27)をさらに備えることを特徴とする、請求項1〜10のいずれか1項に記載の予充填可能薬剤送達装置(1)。
- 前記管状筒がその送達完了位置に到達した時、前記保持手段を解除する無効化手段(15c、30b、33)をさらに備えることを特徴とする、請求項11に記載の予充填可能薬剤送達装置(1)。
- 前記ハウジング(10)をその引込位置からその保護位置へと自動的に移動させる付勢手段(3)をさらに備え、前記付勢手段は、前記ハウジングが前記保持手段によってその引込位置にある応力状態に保持され、前記保持手段が解除されると、前記ハウジングがその保護位置にある伸展位置へと伸展することを特徴とする、請求項12に記載の予充填可能薬剤送達装置(1)。
- 前記保持手段が、前記ハウジング上に位置付けられ、それらが前記付勢手段(3)をその応力状態に保持する休止位置から、前記付勢手段が自由に伸展する屈曲位置へと半径方向に屈曲可能である柔軟な脚条片(15)を含み、前記無効化手段は前記管状筒の前記遠位端(30b、33)を含み、前記遠位端は、前記管状筒がその送達完了位置に到達すると前記柔軟な脚状片と接触して、これを半径方向に屈曲させ、それによって前記付勢手段を釈放して、これが前記ハウジングをその保護位置へと移動させることを特徴とする、請求項13に記載の予充填可能薬剤送達装置(1)。
- 前記ハウジング(10)がその保護位置にいったん到達すると、それがその引込位置に戻るのを防止するロック手段(4)をさらに備えることを特徴とする、請求項1〜14のいずれか1項に記載の予充填可能薬剤送達装置(1)。
- 前記針(2)の近位端(2a)が、前記ニードルハブ(20、22)の近位端を越えて近位側に延びることを特徴とする、請求項2〜15のいずれか1項に記載の予充填可能薬剤送達装置(1)。
- 前記管状筒の近位端(30a)に、使用者が前記管状筒に遠位方向の圧力をかけるための押し面を形成するように意図された外側フランジ(6)がさらに設けられていることを特徴とする、請求項1〜16のいずれか1項に記載の予充填可能薬剤送達装置(1)。
- 請求項17に記載の予充填可能薬剤送達装置(1)を備え、前記管状筒(30)が前記ハウジング(10)に組み付けられ、前記密封手段がその有効状態にあり、前記管状筒の、前記ニードルハブ(20)の近位側に位置付けられた部分に、送達されるべき薬剤(7)が充填され、前記管状筒の前記近位端(30a)がストッパ(8)で閉鎖されることを特徴とする予充填型薬剤送達装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP12305732.5A EP2679262B1 (en) | 2012-06-25 | 2012-06-25 | Prefillable drug delivery device |
EP12305732.5 | 2012-06-25 |
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JP2014004372A JP2014004372A (ja) | 2014-01-16 |
JP2014004372A5 JP2014004372A5 (ja) | 2016-07-21 |
JP6132680B2 true JP6132680B2 (ja) | 2017-05-24 |
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JP2013131938A Active JP6132680B2 (ja) | 2012-06-25 | 2013-06-24 | 予充填可能薬剤送達装置 |
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US (1) | US9101725B2 (ja) |
EP (1) | EP2679262B1 (ja) |
JP (1) | JP6132680B2 (ja) |
CN (2) | CN203469143U (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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EP2679262B1 (en) * | 2012-06-25 | 2015-02-25 | Becton Dickinson France | Prefillable drug delivery device |
DK3325051T3 (da) * | 2015-07-23 | 2019-10-21 | Shl Medical Ag | Variabel enkeltdosisinjektor |
TWI633903B (zh) * | 2017-04-21 | 2018-09-01 | 戴浙 | 預先裝載藥劑藥囊注射器的裝置 |
EP3476418A1 (en) * | 2017-10-30 | 2019-05-01 | Eurotrol B.V. | Device for extracting a fluid from an ampoule |
WO2019158549A1 (en) * | 2018-02-16 | 2019-08-22 | Becton Dickinson France | Medical device for injecting a composition provided with a safety needle cover |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US2574339A (en) | 1945-02-03 | 1951-11-06 | Marshall L Lockhart | Hypodermic syringe |
US3841329A (en) | 1972-09-11 | 1974-10-15 | Upjohn Co | Compact syringe |
US3980083A (en) | 1975-02-13 | 1976-09-14 | Illinois Tool Works Inc. | Medicament infusor unit |
DE3363818D1 (de) | 1982-12-20 | 1986-07-03 | Meditec Sa | Syringe ampoule |
DE3473565D1 (en) | 1983-05-04 | 1988-09-29 | Medicorp Holding | Unitary dose prefilled syringe |
IT223250Z2 (it) | 1991-04-18 | 1995-06-21 | Tecnomedia Ricerche S R L | Dispositivo per la somministrazione di farmaci |
US6007520A (en) * | 1992-02-12 | 1999-12-28 | Daikyo Gomu Seiko, Ltd. | Medical instrument |
ES2133535T3 (es) * | 1993-02-19 | 1999-09-16 | Sanofi Sa | Jeringa precargada para el almacenamiento y la transferencia de una sustancia medicamentosa liquida y esteril. |
ES2118558T3 (es) * | 1994-02-14 | 1998-09-16 | Sanofi Sa | Modulo inyector para una jeringa. |
FR2778853B1 (fr) | 1998-05-19 | 2000-12-22 | Sedat | Seringue d'injection a protecteur d'aiguille charge par un ressort |
US7329238B2 (en) * | 1999-12-07 | 2008-02-12 | Specialized Health Products Inc. | Safety needle medical bearing devices |
US20060178644A1 (en) * | 2004-12-03 | 2006-08-10 | Reynolds David L | Pharmaceutical cartridge assembly and method of filling same |
EP2039382B1 (de) * | 2007-09-01 | 2010-05-12 | F.Hoffmann-La Roche Ag | Ampulle mit Dichtung in zwei Kompressionszuständen |
WO2009155277A1 (en) * | 2008-06-20 | 2009-12-23 | West Pharmaceutical Services, Inc. | Automatic injection mechanism with frontal buttress |
CN102639170B (zh) * | 2009-09-30 | 2014-10-15 | Shl集团有限责任公司 | 药物输送装置 |
US8721599B2 (en) * | 2010-07-22 | 2014-05-13 | Becton, Dickinson And Company | Dual chamber passive retraction needle syringe |
EP2679262B1 (en) * | 2012-06-25 | 2015-02-25 | Becton Dickinson France | Prefillable drug delivery device |
-
2012
- 2012-06-25 EP EP12305732.5A patent/EP2679262B1/en active Active
-
2013
- 2013-06-24 CN CN201320361833.1U patent/CN203469143U/zh not_active Withdrawn - After Issue
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- 2013-06-24 CN CN201310251289.XA patent/CN103505779B/zh active Active
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CN103505779A (zh) | 2014-01-15 |
CN203469143U (zh) | 2014-03-12 |
EP2679262B1 (en) | 2015-02-25 |
JP2014004372A (ja) | 2014-01-16 |
CN103505779B (zh) | 2017-04-12 |
US9101725B2 (en) | 2015-08-11 |
EP2679262A1 (en) | 2014-01-01 |
US20130345631A1 (en) | 2013-12-26 |
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