JP6082850B2 - 多重区画の製剤形態品 - Google Patents
多重区画の製剤形態品 Download PDFInfo
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- JP6082850B2 JP6082850B2 JP2016537462A JP2016537462A JP6082850B2 JP 6082850 B2 JP6082850 B2 JP 6082850B2 JP 2016537462 A JP2016537462 A JP 2016537462A JP 2016537462 A JP2016537462 A JP 2016537462A JP 6082850 B2 JP6082850 B2 JP 6082850B2
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- GOZDTZWAMGHLDY-UHFFFAOYSA-L sodium picosulfate Chemical compound [Na+].[Na+].C1=CC(OS(=O)(=O)[O-])=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OS([O-])(=O)=O)C=C1 GOZDTZWAMGHLDY-UHFFFAOYSA-L 0.000 description 1
- 229940084026 sodium valproate Drugs 0.000 description 1
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- 239000002910 solid waste Substances 0.000 description 1
- GMJHUSJLZXFFQJ-UHFFFAOYSA-N soquinolol Chemical compound C1N(C=O)CCC2=C1C=CC=C2OCC(O)CNC(C)(C)C GMJHUSJLZXFFQJ-UHFFFAOYSA-N 0.000 description 1
- 229950000137 soquinolol Drugs 0.000 description 1
- 229960002370 sotalol Drugs 0.000 description 1
- ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229930002534 steroid glycoside Natural products 0.000 description 1
- 150000008143 steroidal glycosides Chemical class 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
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- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
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- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
- 229960005371 tolbutamide Drugs 0.000 description 1
- 229960004380 tramadol Drugs 0.000 description 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
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- JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229960002726 vincamine Drugs 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
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- 239000011709 vitamin E Substances 0.000 description 1
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- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
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Description
図1及び図2を参照すると、本明細書での開示は、経口投与に適した製剤形態品100に関し、この製剤形態品100は、1つ以上の区画101a、101bを含み、各々が製剤形態品100の複数の別個の部分102、103、104により範囲を定められており、この別個の部分は、本体部分102、104、キャップ部分103、及びそれらの組み合わせからなる群から選択され、この製剤形態品100は、各々が内部表面105及び外部表面106を含む、少なくとも1つの第1本体部分102及び少なくとも1つの第1キャップ部分103であって、好ましくは第1本体部分の外部表面の少なくとも一部分が第1キャップ部分の内部表面の各々の部分に接するように、第1本体部分102は第1キャップ部分103に伸縮自在に係合可能である、少なくとも1つの第1本体部分102及び少なくとも1つの第1キャップ部分103と、少なくとも1つの第2本体部分104であって、内部表面105及び外部表面106を含み、少なくとも1つの第1本体部分102若しくは第1キャップ部分103又はその両方に伸縮自在に係合可能である、少なくとも1つの第2本体部分104(あるいは第2キャップ部分。第2キャップ部分は等しく及び/又は別の方法として用いられると本明細書では理解されるため)と、を備え、別個の第1区画101aは、第2本体部分104の外部表面106と第1本体部分若しくは第1キャップ部分103又はその両方の内部表面105との間、好ましくは、別個の第1区画101aは、第2本体部分104の外部表面106と第1本体部分若しくは第1キャップ部分103又はその両方の内部表面105との間のみに形成されるように、第2本体部分104の少なくとも1つは、少なくとも1つの第1本体部分102若しくは第1キャップ部分103又はその両方内に構成される。この構成の長所は、多重区画の充填操作の簡易化であり、並びに、いくつかの媒質は、本体間の区画内に事前に充填され、閉じられ、その後、更に充填され、最終的に閉じられ工程の後の段階で最終製剤形態を形成するので柔軟性が向上することである。後者は、例えば、充填工程を実質的に修正する必要なく、カプセル製造業者によるある媒質の事前充填と、医薬品開発業者による他のある媒質の充填(事前充填後の充填)とを可能にする。もう1つの長所には全体容積の最大化が挙げられ、これは同様に、既知の多重区画製剤形態に比べて製剤形態の全体寸法を低減するのを助ける。更に、製剤形態の全体の外観の美的印象(外部形状の観点から)は、標準的なカプセルに対して変わらないので、消費者の受け入れの観点で利点をもたらす。
本明細書に記載の製剤形態品内に、1つ又はそれ以上の信号手段が収容されることがある。
本明細書に記載の製剤形態品は、1つ又はそれ以上の医薬品301を含むことがある。本明細書に記載の製剤形態内に用いられるのに適した医薬品は、あらゆる形態をとってもよく、対象となるヒト又は動物のあらゆる治療のためのものであることがある。これは、薬剤化合物のみでなく、ビタミン、ミネラル、及び同様なものなどの栄養補助食品も含む。
a)ベタメタゾン、チオクト酸、ソタロール、サルブタモール、ノルフェネフリン、silymahn、ジヒドロエルゴタミン、ブフロメジル、エトフィブレート、インドメタシン、オキサゼパム、アセチルジギトキシン、ピロキシカム、ハロペリドール(halopehdol)、一硝酸イソソルビド、アミトリプチリン(amithptyline)、ジクロフェナク、ニフェジピン、ベラパミル、ピリチノール、ニトレンジピン、ドキシサイクリン、ブロムヘキシン、メチルプレドニゾロン、クロニジン、フェノフィブラート、アロプリノール、ピレンゼピン、レボチロキシン、タモキシフェン、メチルジゴキシン、o−(B−ヒドロキシエチル)−ルトシド、プロピシリン、一硝酸アクシロビル、パラセタモール(paracetamolol)、ナフチドロフリル、ペントキシフィリン、プロパフェノン、アセブトロール、1−チロキシン、トラマドール、ブロモクリプチン、ロペラミド、ケトフィネン(ketofinen)、フェノテロール、ドベシル酸カルシウム、プロプラノロール、ミノサイクリン、ニセルゴリン、アンブロキソール、メトプロロール、β−シトステリン(B-sitosterin)、マレイン酸エナラプリル(enalaprilhydro-genmaleate)、ベザフィブラート、硝酸イソソルビド、ガロパミル、キサンチノールニコチナート、ジギトキシン、フルニトラゼパム、ベンシクラン、デクスパンテノール、ピンドロール、ロラゼパム、ジルチアゼム、ピラセタム、フェノキシメチルペニシリン、フロセミド、ブロマゼパム、フルナリジン、エリスロマイシン、メトクロプラミド、アセメタシン、ラニチジン、ビペリデン、メタミゾール、ドキセピン、クロラゼプ酸二カリウム、テトラゼパム、リン酸エストラムスチン、テルブタリン、カプトプリル、マプロチリン、プラゾシン、アテノロール、グリベンクラミド、セファクロル、エチレフリン、シメチジン、テオフィリン、ヒドロモルフォン、イブプロフェン、プリミドン、クロバザム、オキサセプロール、メドロキシプロゲステロン、フレカイニド、Mg−ピリドキサル−5−リン酸グルタミニン酸(Mg-pyhdoxal-5-phosphateglutaminate)、ヒメクロモン、エトフィリンクロフィブラート、ビンカミン、シンナリジン、ジアゼパム、ケトプロフェン、フルペンチキソール、モルシドミン、グリボルヌリド(glibornuhde)、ジメチンデン、メルペロン、ソキノロール、ジヒドロコデイン、クロメチアゾール、クレマスチン、グリソキセピド、カリジノゲナーゼ、オキシフェドリン(oxyfedhne)、バクロフェン、カルボキシメチルシスチン、チオレドキシン、ベタヒスチン、1−トリプトファン、ミルトル、ブロメライン、プレニルアミン、サラゾスルファピリジン、アステミゾール、スルピリド、ベンゼラジド(benzerazid)、ジベンゼピン、アセチルサリチル酸、ミコナゾール、ナイスタチン、ケトコナゾール、ピコ硫酸ナトリウム、コレスチラマート(colestyramate)、ゲムフィブロジル、リファンピン、フルオコルトロン、メキシレチン、アモキシシリン、テルフェナジン、ムコ多糖体ポリ硫酸(mucopolysaccharidpolysulfuric acid)、トリアゾラム、ミアンセリン、チアプロフェン酸(tiaprofensaure)、メチル硫酸アメジニウム(ameziniummethylsulfate)、メフロキン、プロブコール、キニジン、カルバマゼピン、Mg−1−アスパラギン酸、ペンブトロール、ピレタニド、アミトリプチリン、カプロテロン(caproteron)、バルプロ酸ナトリウム、メベベリン、ビサコジル、5−アミノサリチル酸、ジヒドララジン、マルガドレード(magaldrate)、フェンプロクモン、アマンタジン、ナプロキセン、カルテオロール、ファモチジン、メチルドーパ、オーラノフィン、エストリオール、ナドロール、レボメプロマジン、ドキソルビシン、メドフェノキサット(medofenoxat)、アザチオプリン、フルタミド、ノルフロキサシン、フェンジリン、prajmaliumbitartrate、エシンアクロマイシン、アニパミル、ベンゾカイン、[β]−カロテン、クロラムフェニコール、クロロジアゼポキシド(chlorodiazepoxid)、chlormadinoneacetate、クロロチアジド、シンナリジン、クロナゼパム、コデイン、デキサメタゾン、ジクマロール、ジゴキシン、ドロタベリン、グラミシジン(grami-cidine)、グリセオフルビン、ヘキソバルビタールヒドロクロロチアジド、コルチゾール、ヒドロフルメチアジド、ケトプロフェン、ロネチル、メダゼパム、メフルシド、メタンドロステノロン、スルファペリン、ナリジクス酸、ニトラゼパム、ニトロフラントイン、エストラジオール、パパベリン、フェナセチン、フェノバルビタール、フェニルブタゾン、フェニトイン、プレドニゾン、レセルピン、スピロノラクチン(spironolactine)、ストレプトマイシン、スルファメチゾール、スルファメタジン、スルファメトキサゾール、sulfamethoxydiazinon、スルファチアゾール、スルフィソキサゾール、テストステロン、トラザミド、トルブタミド、トリメトプリム、チロトリシン、制酸薬、逆流抑制剤、整腸剤、抗ドーパミン剤、プロトンポンプ阻害薬、H2受容体拮抗剤、細胞保護劑、プロスタグランジン類似体、便秘薬、鎮痙薬、下痢止め剤、胆汁酸抑制薬、オピオイド、ベータ受容体遮断剤、カルシウムチャンネル遮断薬、利尿剤、強心配糖体、抗不整脈薬、硝酸塩、抗狭心症薬、血管収縮剤、血管拡張剤、ACE阻害薬、アンジオテンシン受容体遮断剤、アルファ遮断剤、抗凝血剤、ヘパリン、抗血小板薬、線維素溶解薬、抗血友病因子、止血剤、脂質低下薬、スタチン、睡眠薬、麻酔薬、抗精神病薬、抗うつ剤(三環系抗うつ剤、モノアミンオキシダーゼ阻害薬、リチウム塩、選択的セロトニン再取り込み阻害薬を含む)、制吐薬、抗けいれん剤、抗てんかん薬、抗不安薬、バルビツール酸塩、運動障害薬、興奮剤(アンフェタミンを含む)、ベンゾジアゼピン、シクロピロロン(cyclopyrrolone)、ドーパミン拮抗薬、抗ヒスタミン剤、コリン作動薬、抗コリン作用薬、吐剤、カンナビノイド、5−HT拮抗剤、鎮痛剤、筋弛緩薬、抗生剤、サルファ剤、アミノグリコシド抗生物質、フルオロキノロン類、気管支拡張剤、非ステロイド系抗炎症薬、抗アレルギー薬、鎮咳薬、粘液溶解薬、充血除去剤、コルチコステロイド、ベータ受容体拮抗剤、抗コリン作用薬、ステロイド、アンドロゲン、抗アンドロゲン、ゴナドトロピン、コルチコステロイド、成長ホルモン、インシュリン、抗糖尿病薬(スルホニル尿素、ビグアニド/メトホルミン、及びチアゾリジンジオンを含む)、甲状腺ホルモン、抗甲状腺薬、カルシトニン、ジホスホン酸塩、バソプレシン類似体、避妊薬、卵胞刺激ホルモン、黄体形成ホルモン、ゴナドトロピン放出阻害薬、プロゲストゲン、ドーパミン作動薬、エストロゲン、プロスタグランジン、ゴナドレリン、クロミフェン、タモキシフェン、ジエチルスチルベストロール、抗マラリア剤、駆虫薬、抗アメーバ薬、抗ウイルス剤、抗原虫薬、ワクチン、免疫グロブリン、免疫抑制剤、インターフェロン、モノクローナル抗体、及びこれらの混合物などの医薬品(医薬品有効成分とも呼ばれる);
b)ビタミン、例えば、ビタミンA、D、E、及びKなどの脂溶性ビタミン、並びに、ビタミンC、ビオチン、葉酸、ナイアシン、パントテン酸、リボフラビン、チアミン、ビタミンB6、ビタミンB12、及びこれらの混合物などの水溶性ビタミン;
c)カルシウム、クロム、銅、フッ化物、ヨウ素、鉄、マグネシウム、マンガン、モリブデン、リン、カリウム、セレン、ナトリウム(塩化ナトリウムを含む)、亜鉛、及びこれらの混合物などのミネラル;
d)ハーブ又は他の植物性薬品、アミノ酸、並びに、酵素、臓器組織、分泌腺、及び代謝産物などの物質、並びに、食事成分の濃縮物、代謝産物、構成物質、抽出物、及びこれらの混合物などの栄養補助食品;
e)Homeopathic Pharmacopoeia of the United States Revision Service(HPRS)に掲載のもの、及びこれらの混合物などのホメオパシー成分。もちろん、HPRSは定期的に更新されること、並びに、本発明は、HPRSに追加されることがあるホメオパシー成分及び前述のあらゆる組み合わせの混合物を含むことが認識されなければならない。
本明細書に記載の製剤形態品は、多数の方法及び応用で用いることができ、下記の節は、記載の製剤形態品が特に有益であり得る方法のいくつかを述べるであろう。
Claims (15)
- 経口投与に適した製剤形態品(100)であって、1つ以上の区画(101a、101b)を含み、各々が前記製剤形態品(100)の複数の別個の部分(102、103、104)により範囲を定められており、前記別個の部分は、本体部分(102、104)、キャップ部分(103)、及びそれらの組み合わせからなる群から選択され、前記製剤形態品(100)は、
少なくとも1つの第1本体部分(102)及び少なくとも1つの第1キャップ部分(103)であって、各々は内部表面(105)及び外部表面(106)を含み、前記第1本体部分(102)は前記第1キャップ部分(103)と伸縮自在に係合可能である、少なくとも1つの第1本体部分(102)及び少なくとも1つの第1キャップ部分(103)と、
少なくとも1つの第2本体部分(104)であって、内部表面(105)及び外部表面(106)を含み、少なくとも1つの前記第1本体部分(102)若しくは前記第1キャップ部分(103)又はその両方に伸縮自在に係合可能である、少なくとも1つの第2本体部分(104)と、を備える製剤形態品(100)であって、
別個の第1区画(101a)が、前記第2本体部分(104)の前記外部表面(106)と前記第1本体部分(102)若しくは前記第1キャップ部分(103)又はその両方の前記内部表面(105)との間に形成されるように、前記第2本体部分(104)の少なくとも1つは、少なくとも1つの前記第1本体部分(102)若しくは前記第1キャップ部分(103)又はその両方の中に構成されることを特徴とする、製剤形態品(100)。 - 前記第1キャップ部分(103)が前記第1本体部分(102)、前記第2本体部分(104)、又はその両方と伸縮自在に接合されると、前記第2本体部分(104)が、前記第1本体部分(102)及び前記第1キャップ部分(103)により形成される容積を少なくとも2つの別個の区画に分けるように、前記第2本体部分(104)の少なくとも1つが、前記第1本体部分(102)内に構成される、請求項1に記載の製剤形態品(100)。
- 前記第1キャップ部分(103)の前記内部表面(105)の少なくとも一部分が前記第1本体部分(102)の前記外部表面(106)の少なくとも一部分に接するように、前記第1本体部分(102)は、前記第1キャップ部分(103)と伸縮自在に係合され、前記第1本体部分(102)の前記内部表面(105)の少なくとも一部分が、前記第2本体部分(104)の前記外部表面(106)の少なくとも一部分に接するように、少なくとも前記第2本体部分(104)は、前記第1本体部分(102)と伸縮自在に係合するように構成される、請求項1又は2に記載の製剤形態品(100)。
- 第2区画(101b)は、前記第2本体部分(104)の少なくとも1つの前記内部表面(105)と前記第1キャップ部分(103)の前記内部表面(105)との間に形成されるように、前記第2本体部分(104)は構成される、請求項1から3のいずれか一項に記載の製剤形態品(100)。
- 前記本体部分(102、104)及び前記キャップ部分(103)の各々は、開放端(201)及び閉鎖端(202)を含み、好ましくは実質的に管状の形状の半閉鎖容積が形成されるように前記開放端は開放しているのみの端であり、前記第1本体部分(102)及び少なくとも前記第2本体部分(104)は、前記開放端(201)に近接した第1領域(A1、A1’)、及び前記閉鎖端(202)に近接し、かつ前記開放端(201)から離れた第2領域(A2、A2’)を含み、前記第1本体部分(102)の面積比(A1/A2)は、前記第2本体部分(104)の面積比(A1’/A2’)より小さい、請求項1から4のいずれか一項に記載の製剤形態品(100)。
- 前記第2本体部分(104)の前記面積比(A1’/A2’)は、少なくとも1.1倍、好ましくは少なくとも1.2倍、より好ましくは少なくとも1.3倍、更により好ましくは1.4倍から2.5倍、前記第1本体部分(102)の前記面積比(A1/A2)より大きい、請求項4に記載の製剤形態品(100)。
- 前記本体部分(102、104)及び前記キャップ部分(103)は各々、1つ又はそれ以上の突起係止手段(107)及び/あるいは1つ又はそれ以上の陥凹係止手段(108)を含み、前記本体部分(102、104)、前記キャップ部分(103)及び/又はそれらの組み合わせを一体に結合する係止力をもたらすように、前記突起係止手段(107)は前記陥凹係止手段(108)と機械的に係合可能で、好ましくは、前記突起係止手段(107)は、Y軸に垂直な平面に沿って前記外部表面(106)から前記内部表面(105)の方向に突出した係止環の形をしており、前記陥凹係止手段(108)は、陥凹部が前記外部表面(106)から始まり前記内部表面(105)に向かって伸びている陥凹環の形をしている、請求項1から6のいずれか一項に記載の製剤形態品(100)。
- 少なくとも前記第1本体部分及び前記第2本体部分(102、104)各々は、Y軸に垂直な軸に沿って1つ又はそれ以上の陥凹係止手段(108)と直列に構成された、1つ又はそれ以上の突起係止手段(107)を含む、請求項7に記載の製剤形態品(100)。
- 少なくとも前記第1区画(101a)は、前記第1本体部分(102)及び少なくとも前記第2本体部分(104)の1つにより、好ましくは前記第1本体部分(102)及び少なくとも前記第2本体部分(104)の1つのみにより、好ましくは前記第1本体部分(102)の前記内部表面(105)及び前記第2本体部分(104)の前記外部表面(106)により、範囲を定められ、少なくとも第2区画(101b)は、前記第1キャップ部分(103)及び少なくとも1つの前記第2本体部分(104)の1つにより、好ましくは前記第1キャップ部分(103)及び少なくとも1つの前記第2本体部分(104)の1つのみにより、好ましくは前記第1キャップ部分(103)の前記内部表面(105)及び前記第2本体部分(104)の前記内部表面(105)により範囲を定められる、請求項1から8のいずれか一項に記載の製剤形態品(100)。
- 1つ又はそれ以上の更なる第2本体部分を含み、前記更なる第2本体部分は、前記更なる第2本体部分の外部表面と少なくとも1つの前記第2本体部分(104)の前記内部表面との間に、少なくとも1つの更なる区画が形成されるように、少なくとも1つの前記第2本体部分内に各々構成される、請求項1から9のいずれか一項に記載の製剤形態品(100)。
- 前記第1区画(101a)は、第1医薬品又は信号手段を内部に含み、前記区画のもう1つは、第2医薬品を内部に含む、請求項1から10のいずれか一項に記載の製剤形態品(100)。
- 前記第1医薬品及び前記第2医薬品は、固体又は液体形状であり、好ましくは前記第1医薬品及び前記第2医薬品は異なる相にある、請求項11に記載の製剤形態品(100)。
- 前記製剤形態品を通して前記第2本体部分(104)及び/又は前記第1区画(101a)が見えるように、前記第1本体部分(102)は、半透明である、請求項1から12のいずれか一項に記載の製剤形態品(100)。
- 液体封止部は、前記第2本体部分(104)の前記外部表面(106)と前記第1本体部分の前記内部表面(105)との間、並びに/又は前記第1本体部分(102)の前記外部表面(106)と前記第1キャップ部分(103)の前記内部表面(105)との間に含まれ、好ましくは、乾燥後、封止液が前記外部表面(106)と前記内部表面(105)との間の間隔に入れるように、前記液体封止部は形成される、請求項1から13のいずれか一項に記載の製剤形態品(100)。
- 請求項1から14のいずれか一項に記載の製剤形態品(100)を充填する方法であって、前記方法は、好ましくは連続に、
第1本体部分(102)を供給する工程と、
前記第1本体部分(102)に第1媒質を充填する工程と、
前記第1媒質を収容するために、及び任意に、前記第2本体部分(104)を前記第1本体部分(102)に結合するために、第1区画(101a)が形成されるように、第2本体部分(104)を前記第1本体部分(102)内に挿入する工程と、
前記第2本体部分(104)に第2媒質を充填する工程と、
任意に、前記第2媒質を収容するために第2区画(101b)が形成されるように、第1キャップ部分(103)を前記第1本体部分(102)若しくは前記第2本体部分(104)又はその両方と接合する工程と、
を含み、任意に、前記第1媒質は、固体若しくは液体状態の医薬品若しくは信号手段から選択され、前記第2媒質は、固体若しくは液体状態の医薬品から選択される、方法。
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CN104010617B (zh) * | 2011-10-06 | 2017-05-10 | 生物胶囊药物和营养产品私人有限公司 | 胶囊的制造方法和装置 |
US9980905B2 (en) | 2013-12-03 | 2018-05-29 | Capsugel Belgium Nv | Dosage form articles |
EP3028694B1 (en) | 2014-12-02 | 2017-07-12 | Capsugel Belgium NV | Dosage form articles for delayed release |
CN108366970A (zh) * | 2015-10-09 | 2018-08-03 | 科姆博盖股份有限公司 | 具有内部隔片和固体成分的胶囊 |
WO2017081569A1 (en) * | 2015-11-13 | 2017-05-18 | Binutra Incorporated | Capsule and method of manufacturing a capsule |
ES2897981T3 (es) | 2016-06-28 | 2022-03-03 | Asamedic As | Composición de dos componentes que comprende ácido acetilsalicílico |
WO2018078483A1 (en) * | 2016-10-27 | 2018-05-03 | Combocap, Inc. | A comestible capsule and method and apparatus for manufacturing same |
EP3501522A1 (en) | 2017-12-22 | 2019-06-26 | Asamedic AS | Compositions comprising acetylsalicylic acid and a phosphate salt |
EP3501523A1 (en) | 2017-12-22 | 2019-06-26 | Asamedic AS | Two-component compositions comprising acetyl salicylic acid and a carbonate salt |
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FR1454013A (fr) * | 1965-08-18 | 1966-07-22 | Pluripharm | Mode de présentation de deux médicaments associés |
WO2002007710A2 (en) | 2000-07-20 | 2002-01-31 | Mw Encap Limited | Delivery device |
US7670612B2 (en) * | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
ATE526952T1 (de) * | 2005-05-20 | 2011-10-15 | Dow Global Technologies Llc | Überwachung der korrekten zufuhr oraler arzneimittel mittels radiofrequenzidentifikationsetiketten |
US8377471B2 (en) * | 2005-08-09 | 2013-02-19 | Capsugel Belgium Nv | Container |
WO2007047371A2 (en) * | 2005-10-14 | 2007-04-26 | Microdose Technologies, Inc. | Pharmaceutical packaging of an oral dosage combination |
JP5667874B2 (ja) | 2007-10-19 | 2015-02-12 | ファイザー・プロダクツ・インク | マルチコンパートメント容器 |
PL2276445T3 (pl) * | 2008-05-12 | 2012-12-31 | Capsugel Belgium Nv | Ulepszona kapsułka z odpowietrznikami |
CN104010617B (zh) * | 2011-10-06 | 2017-05-10 | 生物胶囊药物和营养产品私人有限公司 | 胶囊的制造方法和装置 |
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EP2777802A1 (en) | 2014-09-17 |
US9561189B2 (en) | 2017-02-07 |
EP3077086B1 (en) | 2017-12-13 |
CA2932562C (en) | 2017-10-17 |
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