JP6074070B2 - 化学−光学センサスポットにおける浸透圧変動の補正 - Google Patents
化学−光学センサスポットにおける浸透圧変動の補正 Download PDFInfo
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/775—Indicator and selective membrane
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7786—Fluorescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/062—LED's
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/13—Standards, constitution
Description
測定された発光応答ベクトル
測定された発光応答を、第1モーメントの時間の後に基準染料に基づいて、式(II)
前記ガス濃度を、結果として得られる発光応答ベクトル
を備える。
品質評価は、式(I)
ここで、α及びβは、双方とも時間変化であり、
実数部(α)は、基準染料の実数部と指示染料の実数部の合計である。これらの値を取得すると、発光応答の虚数部(β)を、例えば経時的に又は幾つかの測定に対して更に分析することができる。例えば検出可能な虚数部(β)の遅い及び/又は段階的変動が存在する場合、これは、許容可能な測定品質を示すことができる。一方、検出可能な虚数部(β)の早い変化又は揺らぎ変動(fluctuating variation)が存在する場合、これは許容可能でない測定品質を示すことがある。
例1−浸透圧変動;ゼロ−モル浸透圧濃度の純水(demi-water)への移動
第1の実験では、センサスポットは、18g/l NaClで調整され、これはセンサが典型的に設計されるノミナルの生理的浸透圧の2倍である。t=0では、センサが、モル浸透圧濃度の純水に移動され、変化するCO2濃度で泡立つ(bubble)。統計値によると、水は、スポットの内と外の浸透圧を均衡させるようにスポットへ入る。その結果、感度が上がるが、これは、より多くのH3O+イオンが利用可能になり、pH感応性の指示染料に反応するようになるという事実による可能性が高い(図3も参照されたい)。
第2の実験では、スポットを、液体を調整する純水から生理食塩溶液に移した。ここで、水は、センサスポットから出るよう動き、感度は落ちる(図4も参照されたい)。
例1の基準染料からの応答は、
虚数部は、適用されるCO2変調に対して非感応であり、4000分以降に一定のレベルになるまで、指数的増加を示し(図6Aも参照されたい)、これは、センサ内及び外部の浸透圧が均衡になるまでの水輸送として説明可能である。
次のステップでは、例1のセンサ応答を、基準染料に基づいて補償した。最初に、(基準染料を表す)虚数部の相対的変化δ(t)が、
この値は、
ここで、kは、2つの染料のモル浸透圧濃度の感度の比を反映する定数である。この結果が図7に示されており、図7Aでは蛍光発光の虚数部を提供し、図7Bでは蛍光発光の補正された実数部を提供している。
図2に示される基準染料からの応答を、
虚数部は、適用されるCO2変調に対して非感応であり、指数的減少を示す(図9Aも参照されたい)。
次のステップでは、例2のセンサ応答を、基準染料に基づいて補償した。最初に、(基準染料を表す)虚数部の相対的変化δ(t)が、
この値は、
ここで、kは、2つの染料のモル浸透圧濃度の感度の比を反映する定数である。続いて、CO2の部分がα’(t)及びβ(t)に基づいて計算された。
Claims (15)
- ガス濃度を光学的に決定する方法であって、少なくとも2つの発光染料を使用し、1つは、発光応答に関してガス濃度に感応性がなく(基準染料)、2つめは、前記発光応答に関してガス濃度に感応性があり(指示染料)、両染料は、結果として得られる位相角がガス濃度を示すよう、異なる発光減衰時間を示し、第1モーメントの時間内の前記基準染料の検出される発光振幅が、前記モーメントの後に感度変化を補正するために使用される、方法。
- 前記発光染料が単一の光源によって励起される、
請求項1に記載の方法。 - 前記発光染料が同時に励起される、
請求項1又は2に記載の方法。 - 前記発光染料が化学−光学センサユニットの感知層において提供される、
請求項1又は2に記載の方法。 - 前記化学−光学センサユニットは、前記感知層に隣接して少なくとも1つのガス透過層を備え、濃度を測定すべきガスが、当該ガス透過層を通過して前記感知層に向かうように構成される、
請求項4に記載の方法。 - 前記ガス透過層は、光が当該ガス透過層を通過することを防ぐように構成される、
請求項5に記載の方法。 - 光学センサは、前記ガス透過層と前記光学センサが適用される表面層との間に少なくとも置かれる接触媒とともに動作するように構成される、
請求項5又は6に記載の方法。 - 単一の検出器により前記基準染料と前記指示染料の発光応答の相挙動を測定し、前記測定された相挙動による両発光染料の全体の強度と独立の発光応答ベクトル
前記測定された発光応答ベクトル
前記測定された発光応答を第1モーメントの時間の後に前記基準染料に基づいて、式(II)
前記ガス濃度を、結果として得られる前記発光応答ベクトル
を備える、請求項1、2、5又は6に記載の方法。 - 虚数部(β)及び測定された発光応答の実数部(α)が、ローパスフィルタされる、
請求項1、2、5又は6に記載の方法。 - ある浸透環境における前記基準染料の発光と前記指示染料の発光との間の定常状態比を、1つ以上の異なる浸透環境のキャリブレータとして使用する、
請求項1に記載の方法。 - ある浸透環境における前記基準染料の発光と前記指示染料の発光との間の定常状態比のダイナミクスを、変化する浸透環境のダイナミクスのキャリブレータとして使用する、
請求項1に記載の方法。 - ガス濃度を決定する光学センサの測定の品質評価のための方法であって、少なくとも2つの発光染料を使用し、1つめの染料は、発光応答に関してガス濃度に感応性がなく(基準染料)、2つめの染料は、前記発光応答に関してガス濃度に感応性があり(指示染料)、両染料は、結果として得られる位相角がガス濃度を示すよう、異なる発光減衰時間を示し、第1モーメントの時間内の前記基準染料の検出される発光振幅が、前記モーメントの後の感度変化を示し、
前記品質評価は、式(I)
方法。 - 前記ガス濃度は、血液ガス濃度である、
請求項1、2、5、6、10、11又は12のいずれか一項に記載の方法。 - 前記感度変化は、浸透圧的に不均衡な環境で起こる、
請求項1、2、5、6、10、11又は12のいずれか一項に記載の方法。 - 前記ガス濃度の決定は、人間の皮膚におけるCO2濃度の経皮決定である、
請求項1、2、5、6、10、11又は12のいずれか一項に記載の方法。
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