JP6039256B2 - Solubilization accelerator - Google Patents

Description

  The present invention relates to a solubilization accelerator that promotes solubilization of a poorly water-soluble substance in an aqueous solvent, a solubilization accelerator composition obtained by dissolving the solubilization accelerator in an aqueous solvent, and the solubilization accelerator composition. And an anionic surfactant, a nonionic surfactant, a poorly water-soluble substance and an aqueous solvent. The solubilized composition of the present invention relates to a composition in which the amount of a surfactant used for solubilizing a poorly water-soluble substance in an aqueous solvent is reduced.

Fragrances containing fragrances are widely used to reduce discomfort associated with odors in living spaces such as rooms, entrances, toilets, and cars, and to impart fragrances. Various forms such as liquids, gels, solids, and aerosols are known as fragrances. Among these forms, the liquid type can be broadly classified into aqueous, alcoholic and oil-soluble, and is used together with a spray type or wicking type fragrance device. Among them, the aqueous liquid fragrance composition is widely used because it has low flammability and is advantageous in terms of cost.
Since many of the fragrances are hardly soluble in water, it is necessary to solubilize the fragrance using a surfactant in the aqueous liquid fragrance composition. However, since the surfactant is non-volatile, the surfactant accumulates in the wicking portion during use, and has the disadvantage that the volatile property of the perfume deteriorates.

In order to solve the above problems, several methods for improving the volatility of the aqueous liquid fragrance composition have been proposed. For example, in Patent Document 1 (Japanese Patent Laid-Open No. 10-248912) and Patent Document 2 (Japanese Patent Laid-Open No. 4-231058), isoprene such as 3-methyl-3-methoxybutanol is used as a perfume solubilizing agent during formulation. It has been reported that a fragrance component can be released at a constant volatilization rate for a long period of time without using a surfactant that is a non-volatile component by blending a system solvent.
However, in the above method, it is necessary to use a larger amount of isoprene-based solvent as compared with the case of using a surfactant, and there are safety problems and cost problems due to a reduction in flash point. In addition, since isoprene-based solvents such as 3-methyl-3-methoxybutanol have a specific odor, there is a concern about the influence on the incense and the change in fragrance caused by volatilization when used in a large amount. . Furthermore, isoprene-based solvents such as 3-methyl-3-methoxybutanol have low volatility, and the volatilization rate of the aroma component may decrease when used in a large amount.

Japanese Patent Laid-Open No. 10-248912 Japanese Patent Laid-Open No. 4-231058

  Under such circumstances, it is desired to provide a solubilized composition that has excellent transparency stability even after storage for a long time, has a good product image, is highly safe, and can be highly evaluated in the market. ing. Moreover, provision of the solubilization promoter composition which can prepare this solubilization composition, and the solubilization promoter composition formed by melt | dissolving this solubilization promoter in an aqueous solvent is calculated | required. Such a solubilization promoter, solubilization promoter composition, and further solubilization composition should be suitably used in the fields of cosmetics, toiletry products, pharmaceuticals and quasi-drugs in addition to the aqueous liquid fragrance composition. Can do.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors have promoted the solubilization of a poorly water-soluble substance in an aqueous solvent by using gluconate, and furthermore, the poorly water-soluble substance in an aqueous solvent. Was found to be stable without cloudiness or phase separation, and the transparency of the solubilized composition was maintained, thereby completing the present invention.

That is, the present invention includes the following solubilization accelerator, solubilization accelerator composition obtained by dissolving the solubilization accelerator in an aqueous solvent, further the solubilization accelerator composition, and an anionic surfactant. And a solubilized composition containing a nonionic surfactant, a hardly water-soluble substance and an aqueous solvent.
[1] A solubilization accelerator for a poorly water-soluble substance containing gluconate as an active ingredient.
[2] One or two gluconates selected from the group consisting of sodium gluconate, potassium gluconate, calcium gluconate, magnesium gluconate, manganese gluconate, zinc gluconate, iron gluconate and copper gluconate The solubilization promoter according to [1], which is a species or more.
[3] The solubilization accelerator according to [1] or [2], wherein the poorly water-soluble substance is a fragrance or a repellent.
[4] A solubilization accelerator composition comprising the solubilization accelerator according to any one of [1] to [3] and an aqueous solvent.
[5] The solubilization promoter composition according to [4], further comprising at least one of an auxiliary salt and a preservative.
[6] The solubilization promoter composition according to [5], wherein the auxiliary salt is one or more selected from the group consisting of sodium citrate, potassium citrate and sodium malate.
[7] The solubilization accelerator composition according to [5] or [6], wherein the preservative is one or more selected from the group consisting of potassium sorbate and sodium benzoate.
[8] The solubilization composition comprising the solubilization accelerator composition according to any one of [4] to [7], an anionic surfactant, a nonionic surfactant, a hardly water-soluble substance, and an aqueous solvent. object.
[9] The solubilized composition according to [8], wherein the total amount of the anionic surfactant and the nonionic surfactant is 0.3 to 5 parts by mass with respect to 1 part by mass of the poorly water-soluble substance.
[10] The solubilized composition according to [8] or [9], wherein the content of the solubilization accelerator in the composition is 0.01 to 2% by mass.
[11] The solubilized composition according to any one of [8] to [10], wherein the content of the anionic surfactant in the composition is 0.05 to 20% by mass.
[12] The solubilized composition according to any one of [8] to [11], wherein the anionic surfactant is a dialkylsulfosuccinate.
[13] The solubilized composition according to any one of [8] to [12], wherein the content of the nonionic surfactant in the composition is 0.05 to 20% by mass.
[14] The nonionic surfactant is one or more selected from the group consisting of polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether and polyoxyethylene hydrogenated castor oil, [8] The solubilized composition according to any one of to [13].
[15] A fragrance comprising the solubilized composition according to any one of [8] to [14], further comprising a base acceptable for the fragrance.
[16] A cosmetic comprising the solubilized composition according to any one of [8] to [14], further containing a base acceptable for cosmetics.
[17] A toiletry product comprising the solubilized composition according to any one of [8] to [14], further containing a base acceptable for a toiletry product.
[18] A pharmaceutical comprising the solubilized composition according to any one of [8] to [14], further comprising a base acceptable for the pharmaceutical.
[19] A quasi drug comprising the solubilized composition according to any one of [8] to [14], further comprising a base acceptable for the quasi drug.
[20] Use of gluconate as a solubilizer.

  By using the solubilization accelerator of the present invention or the solubilization accelerator composition obtained by dissolving the solubilization accelerator in an aqueous solvent, the blending amount of the poorly water-soluble active ingredient can be increased, and the functionality is improved. The solubilized composition having excellent cost performance is provided by reducing the amount of the surfactant added. In addition, a solubilized composition is provided that has excellent transparency stability even after storage for a long time, a good product image, high safety, and high evaluation in the market. The solubilized composition of the present invention is suitably used as a fragrance, a cosmetic, a toiletry product, a pharmaceutical product, a quasi-drug, and the like.

  Hereinafter, the solubilization accelerator, the solubilization accelerator composition and the solubilization composition of the present invention will be specifically described.

  The solubilization promoter of the present invention is an additive used to promote the solubilizing power of a surfactant when a poorly water-soluble substance is solubilized in an aqueous solvent using the surfactant. The solubilization promoter composition of the present invention is a composition that improves the solubilization promoting effect prepared by dissolving the solubilization promoter in a small amount of an aqueous solvent before mixing with the poorly water-soluble substance. is there. The solubilized composition of the present invention is a composition prepared by adding the solubilizer or solubilizer composition to a mixture of a poorly water-soluble substance and a surfactant, and further adding an aqueous solvent. In a preferred embodiment of the present invention, the solubilized composition of the present invention is excellent in transparency, and the transparency is maintained even during the storage period.

  The poorly water-soluble substance (hereinafter sometimes referred to as “component (A)”) to be solubilized in the present invention is not particularly limited, and includes a wide variety of poorly water-soluble substances. For example, fragrance raw material oils such as limonene, citral, lemon oil, orange oil; fragrances such as formulated fragrances; oil-soluble repellents such as diet (N, N-diethyl-toluamide) and p-menthane-3,8-diol Oil-soluble vitamins such as vitamin A and vitamin E; cosmetic raw material oils such as triglyceride, liquid paraffin, and squalane; and other oil-soluble poorly water-soluble substances used as repellents, cosmetics and pharmaceutical raw materials . Among these, fragrances such as fragrance raw material oils and blended fragrances are preferably exemplified.

The solubilization accelerator for a poorly water-soluble substance according to the first aspect of the present invention (hereinafter sometimes referred to as “component (B)”) contains gluconate as an active ingredient.
Examples of the gluconate used in the present invention include sodium gluconate, potassium gluconate, calcium gluconate, magnesium gluconate, manganese gluconate, zinc gluconate, iron gluconate and copper gluconate. One or more of these can be selected and used. Among them, sodium gluconate, potassium gluconate, zinc gluconate or a combination thereof is preferable, and sodium gluconate, potassium gluconate or a combination thereof is particularly preferable in terms of being able to maintain transparency more suitably during use and inexpensive. preferable.

The solubilization promoter composition according to the second aspect of the present invention contains a solubilization promoter (component (B)) and an aqueous solvent (hereinafter sometimes referred to as “component (G)”). In the solubilization promoter composition of the present invention, the solubilization promoter is preferably dissolved in an aqueous solvent.
In the solubilization accelerator composition of the present invention, water is usually used as an aqueous solvent, but one or two kinds of water-soluble organic solvents such as glycol ethers, polyhydric alcohols and lower alcohols are added to water. These may be selected and mixed for use.
Examples of glycol ethers include 3-methoxy-3-methyl-1-butanol, diethylene glycol monoethyl ether, ethylene glycol monomethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, and dipropylene glycol monomethyl ether.
Examples of the polyhydric alcohols include alcohols having 3 to 6 carbon atoms such as glycerin, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, dipropylene glycol, polyethylene glycol, sorbitol, xylitol, and erythritol; glucose, fructose, Monosaccharides such as xylose; disaccharides such as sucrose, maltose and trehalose are preferred.
As the lower alcohol, monohydric alcohols such as methanol, ethanol, propyl alcohol and isopropyl alcohol are preferably used.

  The solubilization accelerator composition of the present invention preferably further contains an auxiliary salt such as citrate (hereinafter sometimes referred to as “component (C)”) from the viewpoint of promoting solubilization. By using the solubilization accelerator and an auxiliary salt such as citrate in combination, the solubilizing power of the poorly water-soluble substance can be increased as compared with the case where the solubilization accelerator is used alone.

  Examples of auxiliary salts include sodium citrate, potassium citrate, sodium malate, sodium lactate, calcium lactate, sodium tartrate, potassium sodium tartrate, sodium succinate, calcium ascorbate, and potassium aluminum sulfate. One or more of them can be selected and used. Among them, sodium citrate, potassium citrate, sodium malate or a combination thereof is preferable in assisting the solubilization promoting effect of the solubilization promoter.

  The solubilization promoter composition of the present invention preferably contains a preservative such as benzoate (hereinafter sometimes referred to as “component (D)”) from the viewpoint of suppressing the growth of microorganisms. . By adding a preservative, destabilization of the solubilization promoter composition due to generation of mold or the like can be suppressed.

  Examples of preservatives include sodium benzoate, sorbic acid, potassium sorbate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, ethyl paraoxybenzoate, methyl paraoxybenzoate, butyl paraoxybenzoate, and propyl paraoxybenzoate. Can do. One or more of these can be selected and used. Among these, sodium benzoate, potassium sorbate or a combination thereof is preferable from the viewpoint of safety.

  The content of each component in the solubilization accelerator composition of the present invention varies depending on the kind and purpose of the poorly water-soluble substance and the solubilizing composition described later, but is generally as follows.

It is preferable that content of a solubilization promoter (component (B)) is 0.01-40 mass% in a solubilization promoter composition. If the content of the solubilization accelerator is less than 0.01% by mass, the effect of reducing the blending amount of the surfactant may not be sufficiently exhibited while maintaining a good appearance in the solubilized composition described later. In particular, when the poorly water-soluble substance is a fragrance, the effect of reducing the blending amount of the surfactant is not sufficiently exhibited while maintaining good volatility and appearance in the solubilized composition. On the other hand, when the solubilization accelerator is more than 40% by mass, the poorly water-soluble substance cannot be solubilized in the solubilized composition described later, or even if solubilized, insoluble matter is precipitated or the solution becomes cloudy. May end up.
The content of the solubilization accelerator is more preferably 0.03% by mass or more, and further preferably 0.05% by mass or more in the solubilization accelerator composition. Moreover, 35 mass% or less is more preferable, 30 mass% or less is more preferable, 25 mass% or less is especially preferable, and 20 mass% or less is still more preferable.

The content of the auxiliary salt (component (C)) is preferably 0.01 to 40% by mass in the solubilization accelerator composition. If the content of the auxiliary salt is less than 0.01% by mass, the effect of assisting solubilization of the poorly water-soluble substance may be insufficient. On the other hand, if the auxiliary salt is more than 40% by weight, crystals may precipitate at a low temperature.
The content of the auxiliary salt is more preferably 0.05% by mass or more, and further preferably 0.09% by mass or more in the solubilization accelerator composition. Moreover, 35 mass% or less is more preferable, 30 mass% or less is more preferable, 25 mass% or less is especially preferable, and 20 mass% or less is still more preferable.

The content of the preservative (component (D)) is preferably 0.001 to 5% by mass in the solubilization accelerator composition. When the content of the preservative is less than 0.001% by mass, the antiseptic effect is insufficient, so that mold or the like grows in the solubilization accelerator and the quality may be impaired. Moreover, when there are more preservatives than 5 mass%, the solubilization promotion effect may be inhibited.
The content of the preservative is more preferably 0.005% by mass or more, and further preferably 0.01% by mass or more in the solubilization accelerator composition. Moreover, 4 mass% or less is more preferable, and 3 mass% or less is further more preferable.

The content of the aqueous solvent (component (G)) is the balance of the other components, but is usually preferably 30 to 99.98% by mass in the solubilization accelerator composition. If the content of the aqueous solvent is less than 30% by mass, crystals may precipitate at low temperatures. On the other hand, when the amount of the aqueous solvent is more than 99.98% by mass, the effect of assisting the solubilization of the hardly water-soluble substance may not be sufficiently exhibited.
The content of the aqueous solvent is more preferably 35% by mass or more, and further preferably 40% by mass or more in the solubilization accelerator composition. Moreover, 99.69 mass% or less is more preferable, and 99.49 mass% or less is further more preferable. In addition, although the water-soluble organic solvent in an aqueous solvent can be suitably contained as needed, 50 mass% or less is preferable in a solubilization promoter composition normally, and 30 mass% or less is more preferable.

  The solubilization promoter composition of the present invention can be obtained by dissolving each component in an aqueous solvent by a conventional method. For example, a method of dissolving a solubilizer, auxiliary salt and preservative in water is employed.

  The solubilized composition according to the third aspect of the present invention contains a solubilizer composition, an anionic surfactant, a nonionic surfactant, a hardly water-soluble substance, and an aqueous solvent.

Examples of the anionic surfactant (hereinafter sometimes referred to as “component (E)”) used in the solubilized composition of the present invention include alkyl sulfates, polyoxyethylene alkyl ether sulfates, and alkylbenzene sulfones. Acid salt, dialkylsulfosuccinate (eg, sodium dioctylsulfosuccinate), N-acyl amino acid salt, alkyl ether carboxylate, sulfonate, alkyl phosphate, polyoxyethylene alkyl ether phosphate, fatty acid soap, etc. 1 type or 2 types or more can be selected and used from these.
Of these, dialkylsulfosuccinate is preferable. The alkyl group of the dialkylsulfosuccinate is preferably a linear or branched alkyl group having 4 to 10 carbon atoms. For example, nonyl group, pentyl group (amyl group), octyl group, cyclohexyl group, ethylhexyl group, heptyl group, hexyl group, isobutyl group and the like are preferable. Examples of counter ions of dialkyl sulfosuccinate include sodium ion, potassium ion, and ammonium ion. Of these, sodium ion is preferred.
Specific examples of the dialkylsulfosuccinate include sodium diisobutylsulfosuccinate, sodium dioctylsulfosuccinate, sodium dihexylsulfosuccinate, sodium diamylsulfosuccinate and sodium dicyclohexylsulfosuccinate. Of these, sodium dioctyl sulfosuccinate is preferable.

  Examples of the nonionic surfactant (hereinafter sometimes referred to as “component (F)”) used in the solubilized composition of the present invention include polyoxyethylene alkyl ether and polyoxyethylene polyoxypropylene alkyl ether. , Polyoxyethylene hydrogenated castor oil, alkyl alkanolamide, alkyl polyglucoside, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, A polyoxyethylene polyoxypropylene glycol etc. can be mentioned, From these, 1 type (s) or 2 or more types can be selected and used. Among them, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, and polyoxyethylene hydrogenated castor oil are preferable; in particular, addition of polyoxyethylene alkyl ether, ethylene oxide, and propylene oxide having an addition mole number of ethylene oxide of 5 to 30 Polyoxyethylene polyoxypropylene alkyl ether having 5 to 20 moles and polyoxyethylene hydrogenated castor oil having 10 to 100 moles of added ethylene oxide are preferable.

  Examples of the aqueous solvent used in the solubilized composition of the present invention include the same solvents as those exemplified in the aqueous solvent (component (G)) of the solubilization accelerator composition. Usually, it is preferable to use water.

  The content of each component in the solubilized composition of the present invention varies depending on the kind and purpose of the poorly water-soluble substance and the solubilized composition, and cannot be generally specified, but is usually as follows.

The content of the hardly water-soluble substance (component (A)) is preferably 0.03 to 30% by mass in the solubilized composition. When the content of the hardly water-soluble substance is less than 0.03% by mass, the effect of the hardly water-soluble substance may not be sufficiently exhibited in the product. In particular, when the poorly water-soluble substance is a fragrance, there may be a case where a satisfactory scent strength cannot be obtained in the solubilized composition. Further, when the amount of the hardly water-soluble substance is more than 30% by mass, a large amount of the surfactant is required for solubilizing the hardly water-soluble substance in the product. In particular, when the sparingly water-soluble substance is a fragrance, the fragrance may be volatilized during use.
In consideration of these points, the content of the hardly water-soluble substance is preferably selected according to the kind of the hardly water-soluble substance to be used.
The content of the hardly water-soluble substance is more preferably 0.05% by mass or more, and further preferably 0.1% by mass or more in the solubilized composition. Moreover, 25 mass% or less is more preferable, 20 mass% or less is further more preferable, 18 mass% or less is especially preferable, and 15 mass% or less is still more preferable.

The content of the solubilization accelerator (component (B)) is preferably 0.01 to 2% by mass in the solubilized composition. When the content of the solubilization accelerator is less than 0.01% by mass, the effect of reducing the blending amount of the surfactant may not be sufficiently exhibited while maintaining a good appearance. In particular, when the poorly water-soluble substance is a fragrance, the effect of reducing the blending amount of the surfactant is not sufficiently exhibited while maintaining good volatility and appearance. On the other hand, when the solubilization accelerator is more than 2% by mass, the poorly water-soluble substance cannot be solubilized, or even if solubilized, insoluble matter may precipitate or the solution may become cloudy.
The content of the solubilization accelerator is more preferably 0.03% by mass or more, and further preferably 0.05% by mass in the solubilized composition. Moreover, 1.8 mass% or less is more preferable, and 1.5 mass% or less is further more preferable.
In this invention, it is preferable to adjust content of a solubilization promoter composition so that content of a solubilization promoter in a solubilization composition may become the said range.

The content of the auxiliary salt (component (C)) is preferably 0.005 to 2% by mass in the solubilized composition. When the content of the auxiliary salt is less than 0.005% by mass, the effect of assisting solubilization of the poorly water-soluble substance may be insufficient. On the other hand, if the auxiliary salt is more than 2% by weight, crystals may precipitate at low temperatures.
The content of the auxiliary salt is more preferably 0.01% by mass or more, and further preferably 0.03% by mass or more in the solubilized composition. Moreover, 1.8 mass% or less is more preferable, and 1.5 mass% or less is further more preferable.

The content of the preservative (component (D)) can be blended as an optional component when the antiseptic effect needs to function in the solubilized composition.
The content of the preservative is preferably 0.001 to 5% by mass in the solubilized composition. If it is less than 0.001% by mass, the antiseptic effect is insufficient, and mold and the like may grow in the solubilization accelerator, which may impair the quality. Moreover, when it is 5 mass% or more, the solubilization promotion effect may be inhibited.
The content of the preservative is more preferably 0.005% by mass or more, and further preferably 0.01% by mass in the solubilized composition. Moreover, 4 mass% or less is more preferable, 3 mass% or less is more preferable, 3 mass% or less is especially preferable, and 2 mass% or less is still more preferable.

  In the present invention, it is preferable to adjust the content of the solubilization accelerator composition so that the content of the auxiliary salt or the preservative in the solubilized composition falls within the above range. Alternatively, auxiliary salts or preservatives may be further added as necessary.

The content of the anionic surfactant (component (E)) is preferably 0.05 to 20% by mass in the solubilized composition. If the content of the anionic surfactant is less than 0.05% by mass, it may be insufficient to solubilize the poorly water-soluble substance in water. Moreover, when there is more content of an anionic surfactant than 20 mass%, it is economically not preferable. In particular, when the sparingly water-soluble substance is a fragrance, the non-volatile content increases, and the volatilization of the fragrance during use may be hindered.
The content of the anionic surfactant is more preferably 0.08% by mass or more, and further preferably 0.1% by mass or more in the solubilized composition. Moreover, 18 mass% or less is more preferable, 15 mass% or less is more preferable, 13 mass% or less is especially preferable, and 11 mass% or less is still more preferable.

The content of the nonionic surfactant (component (F)) is preferably 0.05 to 20% by mass in the solubilized composition. If the content of the nonionic surfactant is less than 0.05% by mass, it may be insufficient for solubilizing the poorly water-soluble substance. Moreover, when there is more content of a nonionic surfactant than 20 mass%, it is economically not preferable. In particular, when the sparingly water-soluble substance is a fragrance, the non-volatile content increases, and the volatilization of the fragrance during use may be hindered.
The content of the nonionic surfactant is more preferably 0.08% by mass or more, and further preferably 0.1% by mass or more in the solubilized composition. Moreover, 18 mass% or less is more preferable, 15 mass% or less is more preferable, 13 mass% or less is especially preferable, and 11 mass% or less is still more preferable.

The content of the aqueous solvent is the balance of the other components. Although the content of the aqueous solvent varies greatly depending on the application, it is usually preferably 30 to 99.8% by mass in the solubilized composition. In addition, the water-soluble organic solvent in an aqueous solvent can be suitably contained as needed. The content of the water-soluble organic solvent in the solubilized composition should be appropriately determined according to the purpose, but is usually preferably 60% by mass or less and more preferably 30% by mass or less in the solubilized composition. .
Water-soluble organic solvents include ethanol, propanol, isopropanol, butanol, 3-methoxy-3-methyl-1-butanol, benzyl alcohol, ethyl carbitol (diethylene glycol monoethyl ether), ethylene glycol, propylene glycol, dipropylene glycol, Examples include butylene glycol, hexylene glycol, glycerin, ethylene glycol monomethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, and dipropylene glycol monomethyl ether. These water-soluble organic solvents may be used alone or in combination of two or more.
In the present invention, the addition amount of the aqueous solvent is adjusted so that the content of the aqueous solvent in the solubilized composition is in the above range in total with the aqueous solvent in the solubilization accelerator composition.

Specific examples of the poorly water-soluble substance used in the present invention are as described above. Among these, the perfume will be described in more detail below.
The fragrance used in the present invention is not particularly limited as long as it can be used as a fragrance. For example, “Perfume and Flavor Chemicals”, Vol. Iand II, Steffen Arctander, Allured Pub. Co. (1994); “Synthetic fragrance chemistry and product knowledge”, Motoichi Into, Chemical Industry Daily (1996); “Aroma Encyclopedia”, edited by Japan Fragrance Association, Asakura Shoten (1989); Fragrance Part I "(issued January 29, 1999, issued by the Patent Office);" Performerial Material Performance V.3.3 ", Boelens Aroma Chemical Information Service (1996); and" Flower oils and Pf , Danute Lajaujis Anonis, Allured Pub. Co. (1993) and other known synthetic fragrances and natural fragrances.

  Specifically, esters, alcohols, aldehydes, ketones, acetals, phenols, ethers, lactones, furans, hydrocarbons, acids, natural fragrances, and the like can be used.

  Examples of esters include acrylic acid esters (methyl, ethyl, etc.), acetoacetic acid esters (methyl, ethyl, etc.), anisic acid esters (methyl, ethyl, etc.), benzoic acid esters (allyl, isoamyl, ethyl, geranyl, linalyl). , Phenylethyl, hexyl, cis-3-hexenyl, benzyl, methyl, etc.), anthranilate (cinnamyl, cis-3-hexenyl, methyl, ethyl, linalyl, isobutyl, etc.), N-methylanthranilate (methyl, ethyl) Isovaleric ester (amyl, allyl, isoamyl, isobutyl, isopropyl, ethyl, octyl, geranyl, cyclohexyl, citronellyl, terpenyl, linalyl, cinnamyl, phenylethyl, butyl, propyl, hexyl, benzyl, methyl, rho Isobutyric acid ester (isoamyl, geranyl, citronellyl, terpenyl, cinnamyl, octyl, neryl, phenylethyl, phenylpropyl, phenoxyethyl, butyl, propyl, isopropyl, hexyl, benzyl, methyl, ethyl, linalyl, rosinyl, etc.) , Undecylenic acid esters (allyl, isoamyl, butyl, ethyl, methyl, etc.), octanoic acid esters (allyl, isoamyl, ethyl, octyl, hexyl, butyl, methyl, linalyl, etc.), octenoic acid esters (methyl, ethyl, etc.), Octynecarboxylic acid ester (methyl, ethyl, etc.), caproic acid ester (allyl, amyl, isoamyl, methyl, ethyl, isobutyl, propyl, hexyl, cis-3-hexenyl, trans-2-hexenyl, linalyl, Ranyl, cyclohexyl, etc.), hexenoic acid esters (methyl, ethyl, etc.), valeric acid esters (amyl, isopropyl, isobutyl, ethyl, cis-3-hexenyl, trans-2-hexenyl, cinnamyl, phenylethyl, methyl, etc.), formic acid Esters (anisyl, isoamyl, isopropyl, ethyl, octyl, geranyl, citronellyl, cinnamyl, cyclohexyl, terpenyl, phenylethyl, butyl, propyl, hexyl, cis-3-hexenyl, benzyl, linalyl, rosinyl, etc.), crotonic acid ester (isobutyl , Ethyl, cyclohexyl, etc.), cinnamic acid esters (allyl, ethyl, methyl, isopropyl, propyl, 3-phenylpropyl, benzyl, cyclohexyl, methyl, etc.), succinic acid esters (monomenthyl, di-ethyl) Ethyl, dimethyl, etc.), acetate (anisyl, amyl, α-amylcinnamyl, isoamyl, isobutyl, isopropyl, isobornyl, isoeugenyl, eugenyl, 2-ethylbutyl, ethyl, 3-octyl, p-cresyl, o-cresyl, geranyl, α -Or β-Santalyl, cyclohexyl, cycloneryl, dihydrocuminyl, dimethylbenzylcarbinyl, cinnamyl, styryl, decyl, dodecyl, terpenyl, guanyl, neryl, nonyl, phenylethyl, phenylpropyl, butyl, furfuryl, propyl, hexyl, cis -3-hexenyl, trans-2-hexenyl, cis-3-nonenyl, cis-6-nonenyl, cis-3, cis-6-nonadienyl, 3-methyl-2-butenyl, heptyl, benzyl, bornyl, Lucenyl, dihydromyrcenyl, myrtenyl, methyl, 2-methylbutyl, menthyl, linalyl, rosinyl, etc.), salicylic acid ester (allyl, isoamyl, phenyl, phenylethyl, benzyl, ethyl, methyl, etc.), cyclohexyl alkanoic acid ester (cyclohexyl acetic acid) Ethyl, allyl cyclohexylpropionate, allyl cyclohexylbutyrate, allyl cyclohexylhexanoate, allyl cyclohexyldecanoate, allyl cyclohexylvalerate, etc., stearic acid ester (ethyl, propyl, butyl, etc.), sebacic acid ester (diethyl, dimethyl, etc.) Decanoic acid ester (isoamyl, ethyl, butyl, methyl, etc.), dodecanoic acid ester (isoamyl, ethyl, butyl etc.), lactic acid ester (isoamyl, ethyl, butyl etc.), Nanoic acid ester (ethyl, phenylethyl, methyl, etc.), Nonenoic acid ester (allyl, ethyl, methyl, etc.), Hydroxyhexanoic acid ester (ethyl, methyl, etc.), Phenylacetic acid ester (isoamyl, isobutyl, ethyl, geranyl, citronellyl, Cis-3-hexenyl, methyl, etc.), phenoxyacetic acid ester (allyl, ethyl, methyl, etc.), furancarboxylic acid ester (ethyl furancarboxylate, methyl furancarboxylate, hexyl furancarboxylate, isobutyl furanpropionate, etc.), propion Acid esters (anisyl, allyl, ethyl, amyl, isoamyl, propyl, butyl, isobutyl, isopropyl, benzyl, geranyl, cyclohexyl, citronellyl, cinnamyl, tetrahydrofurfuryl, tricyclodecenyl, Butyl, bornyl, methyl, menthyl, linalyl, terpenyl, α-methylpropionyl, β-methylpropionyl, etc.), heptanoic acid ester (allyl, ethyl, octyl, propyl, methyl, etc.), heptine carboxylic acid ester (allyl, ethyl, Propyl, methyl, etc.), myristic acid ester (isopropyl, ethyl, methyl, etc.), phenylglycidic acid ester (ethyl phenylglycidate, ethyl 3-methylphenylglycidate, ethyl p-methyl-β-phenylglycidate) Etc.), 2-methylbutyric acid ester (methyl, ethyl, octyl, phenylethyl, butyl, hexyl, benzyl etc.), 3-methylbutyric acid ester (methyl, ethyl etc.), butyric acid ester (anisyl, amyl, allyl, isoamyl, methyl) , Ethyl, propyl, octyl, g Inyl, linalyl, geranyl, cyclohexyl, citronellyl, cinnamyl, neryl, terpenyl, phenylpropyl, β-phenylethyl, butyl, hexyl, cis-3-hexenyl, trans-2-hexenyl, benzyl, rosinyl, etc.), hydroxybutyric acid ester ( 3-hydroxybutyric acid such as methyl, ethyl, menthyl and the like can be used.

Examples of alcohols include aliphatic alcohols (isoamyl alcohol, 2-ethylhexanol, 1-octanol, 3-octanol, 1-octen-3-ol, 1-decanol, 1-dodecanol, 2,6-nonadienol, nonanol. 2-nonanol, cis-6-nonenol, trans-2, cis-6-nonadienol, cis-3, cis-6-nonadienol, butanol, hexanol, cis-3-hexenol, trans-2-hexenol, 1-undecanol Terpene alcohol (borneol, isoborneol, carveol, geraniol, α- or β-santalol, citronellol, 4-tuyanol, terpineol, 4-terpene, etc.), heptanol, 2-heptanol, 3-methyl-1-pentanol, etc. Neoru, nerol, myrcenol, myrtenol, dihydromyrcenol, tetrahydrocannabinol mill Se Nord, nerolidol, hydroxy citronellol, farnesol, perilla alcohol, rhodinol, linalool, etc.);
Aromatic alcohol (anise alcohol, α-amyl cinnamic alcohol, isopropyl benzyl carbinol, carvacrol, cumin alcohol, dimethyl benzyl carbinol, cinnamic alcohol, phenyl allyl alcohol, phenyl ethyl carbinol, β-phenyl ethyl alcohol, 3 -Phenylpropyl alcohol, benzyl alcohol, etc.) can be used.

Examples of aldehydes include aliphatic aldehydes (acetaldehyde, octanal, nonanal, decanal, undecanal, 2,6-dimethyl-5-heptanal, 3,5,5-trimethylhexanal, cis-3, cis-6-nonadienal. , Trans-2, cis-6-nonadienal, valeraldehyde, propanal, isopropanal, hexanal, trans-2-hexenal, cis-3-hexenal, 2-pentenal, dodecanal, tetradecanal, trans-4-decenal, Trans-2-tridecenal, trans-2-dodecenal, trans-2-undecenal, 2,4-hexadienal, cis-6-nonenal, trans-2-nonenal, 2-methylbutanal, etc.);
Aromatic aldehydes (anisaldehyde, α-amylcinnamic aldehyde, α-methylcinnamic aldehyde, cyclamenaldehyde, p-isopropylphenylacetaldehyde, ethyl vanillin, cuminaldehyde, salicylaldehyde, cinnamaldehyde, o-, m- or p -Tolylaldehyde, vanillin, piperonal, phenylacetaldehyde, heliotropin, benzaldehyde, 4-methyl-2-phenyl-2-pentenal, p-methoxycinnamic aldehyde, p-methoxybenzaldehyde, etc.);
Terpene aldehyde (geranial, citral, citronellal, α-sinensal, β-sinensal, perilaldehyde, hydroxycitronellal, tetrahydrocitral, mirutenal, cyclocitral, isocyclocitral, citronellyloxyacetaldehyde, neral, α-methylenecitrone Lar, mylacaldehyde, Bernaldehyde, safranal, etc.).

Examples of the ketones include cyclic ketones (1-acetyl-3,3-dimethyl-1-cyclohexene, cis jasmon, α-, β- or γ-iron, ethyl maltol, cycloten, dihydronootkatone, 3,4 -Dimethyl-1,2-cyclopentadione, sotron, α-, β-, γ- or δ-damascon, α-, β- or γ-damasenone, nootkatone, 2-sec-butylcyclohexanone, maltol, α-, β- or γ-ionone, α-, β- or γ-methylyonone, α-, β- or γ-isomethylyonone, furaneol, camphor, etc.);
Aromatic ketones (acetonaphthone, acetophenone, anisylideneacetone, raspberry ketone, p-methylacetophenone, anisylacetone, p-methoxyacetophenone, etc.);
Chain ketones (diacetyl, 2-nonanone, diacetyl, 2-heptanone, 2,3-heptanedione, 2-pentanone, methyl amyl ketone, methyl nonyl ketone, β-methyl naphthyl ketone, methyl heptanone, 3-heptanone, 4 -Heptanone, 3-octanone, 2,3-hexanedione, 2-undecanone, dimethyloctenone, 6-methyl-5-hepten-2-one, etc.) can be used.

  Examples of acetals include acetaldehyde diethyl acetal, acetaldehyde diamyl acetal, acetaldehyde dihexyl acetal, acetaldehyde propylene glycol acetal, acetaldehyde ethyl cis-3-hexenyl acetal, benzaldehyde glycerol acetal, benzaldehyde propylene glycol acetal, citral dimethyl acetal, citral diethyl Acetal, citral propylene glycol acetal, citral ethylene glycol acetal, phenylacetaldehyde dimethyl acetal, citronellyl methyl acetal, acetaldehyde phenylethyl propyl acetal, hexanal dimethyl acetal, hexanal dihexyl acetal, hex Nalpropylene glycol acetal, trans-2-hexenal diethyl acetal, trans-2-hexenal propylene glycol acetal, cis-3-hexenal diethyl acetal, heptanal diethyl acetal, heptanal ethylene glycol acetal, octanal dimethyl acetal, nonanal dimethyl acetal , Decanal dimethyl acetal, decanal diethyl acetal, 2-methylundecanal dimethyl acetal, citronellal dimethyl acetal, amber sage (manufactured by Givaudan), ethyl acetoacetate ethylene glycol acetal and 2-phenylpropanal dimethyl acetal it can.

  Examples of phenols that can be used include eugenol, isoeugenol, 2-methoxy-4-vinylphenol, thymol, carvacrol, guaiacol, and chabicol.

  Examples of ethers include anethole, 1,4-cineole, dibenzyl ether, linalool oxide, limonene oxide, nerol oxide, rose oxide, methyl isoeugenol, methyl chabicol, isoamyl phenyl ethyl ether, β-naphthyl methyl ether. , Phenylpropyl ether, p-cresyl methyl ether, vanillyl butyl ether, α-terpinyl methyl ether, citronellyl ethyl ether, geranyl ethyl ether, rose furan, theaspirane, decyl methyl ether, and methyl phenyl methyl ether.

  Examples of lactones include γ- or δ-decalactone, γ-heptalactone, γ-nonalactone, γ- or δ-hexalactone, γ- or δ-octalactone, γ- or δ-undecalactone, δ- Dodecalactone, δ-2-decenolactone, methyl lactone, 5-hydroxy-8-undecenoic acid δ-lactone, jasmine lactone, mentalactone, dihydrocoumarin, octahydrocoumarin and 6-methylcoumarin can be used.

  Examples of furans include furan, 2-methylfuran, 3-methylfuran, 2-ethylfuran, 2,5-diethyltetrahydrofuran, 3-hydroxy-2-methyltetrahydrofuran, 2- (methoxymethyl) furan, 2, 3-dihydrofuran, furfural, 5-methylfurfural, 3- (2-furyl) -2-methyl-2-propenal, 5- (hydroxymethyl) furfural, 2,5-dimethyl-4-hydroxy-3 (2H) -Furanone (furaneol), 4,5-dimethyl-3-hydroxy-2 (5H) -furanone (sotron), 2-ethyl-4-hydroxy-5-methyl-3 (2H) -furanone (homofuranool), 5-ethyl-3-hydroxy-4-methyl-2 (5H) furanone (homosotron), 3-methyl-1,2 Cyclopentanedione (cycloten), 2 (5H) -furanone, 4-methyl-2 (5H) -furanone, 5-methyl-2 (5H) -furanone, 2-methyl-3 (2H) -furanone, 5-methyl -3 (2H) -furanone, 2-acetylfuranone, 2-acetyl-5-methylfuran, furfuryl alcohol, methyl 2-furancarboxylate, ethyl 2-furancarboxylate, and furfuryl acetate can be used.

  Examples of the hydrocarbons include α- or β-bizaborane, β-caryophyllene, p-cymene, terpinene, terpinolene, kadinene, farnesene, limonene, osimene, myrcene, α- or β-pinene, 1,3,5- Undecatriene and valencene can be used.

  Examples of the acids include gellan acid, dodecanoic acid, myristic acid, stearic acid, lactic acid, phenylacetic acid, pyruvic acid, trans-2-methyl-2-pentenoic acid, 2-methyl-cis-3-pentenoic acid, 2- Methyl-4-pentenoic acid and cyclohexanecarboxylic acid can be used.

  Natural flavors include, for example, anise, orange, lemon, lime, mandarin, petit grain, bergamot, lemon balm, grapefruit, elemi, olibanum, lemongrass, neroli, marjoram, angelica root, star anise, basil, bay, columns, chamomile , Caraway, Cardamom, Cascia, Cinnamon, Pepper, Perilla, Cypress, Oregano, Cascarilla, Ginger, Parsley, Pine Needle, Sage, Hyssop, Tea Tree, Mustard, Horseradish, Clarage, Clove, Cognac, Coriander, Estragon, Eucalyptus, Fennel, guaiac wood, dill, kayapte, worm seed, pimento, juniper, phenegreak, garlic, laurel, mace, mill, jujube , Spruce, geranium, citronella, lavender, lavandin, palmarosa, rose, rosemary, sandalwood, oak moss, cedarwood, vetiver, linaloe, boredrose, patchouli, lovedanum, cumin, thyme, ylang ylang, birch, capsicum, celery, trubal sum Gene, Inmortel, Benzoin, Jasmine, Cassie, Tuberose, Reseda, Marigold, Mimosa, Opoponax, Oris, Vanilla and Licorice. Moreover, the fragrance | flavor component contained in these natural fragrance | flavors can also be extracted and used.

  These fragrance | flavors may be used individually by 1 type, and can also be used by flavoring combining 2 or more types arbitrarily. Since the content of the fragrance in the solubilized composition of the present invention varies depending on the type of the fragrance used, etc., it cannot be generally stated, but usually 0.1 to 30% by mass is preferable. When there is too little content of a fragrance | flavor, the intensity | strength of satisfactory fragrance may not be obtained. Moreover, when there is too much content of a fragrance | flavor, content of surfactant for solubilizing a fragrance | flavor will increase and it may inhibit volatilization of the fragrance | flavor at the time of use. It is desirable that the content of the fragrance is appropriately selected according to the type of the fragrance used in consideration of these points.

  Anionic surfactant and nonionic interface per 1 part by weight of fragrance to suppress adverse effects on volatilization of fragrance during use due to increased concentration of surfactant, as well as influence on fragrance formation and fragrance persistence It is desirable that the amount of the active agent is as small as possible. In the present invention, the total content of the anionic surfactant and the nonionic surfactant per 1 part by weight of the fragrance is preferably 0.3 to 1.4 parts by weight. The total content of the anionic surfactant and the nonionic surfactant per 1 part by weight of the fragrance is preferably as small as possible, and since it varies depending on the type or content of the fragrance, it cannot be generally stated, but 1.2 parts by weight The following is more preferable, and 1 part by weight or less is more preferable. The appearance of the solubilized composition is not impaired during use by adjusting the total content of the anionic surfactant and the nonionic surfactant per 1 part by weight of the fragrance to the above range. . If the total content of the anionic surfactant and the nonionic surfactant per 1 part by weight of the fragrance is less than 0.3 parts by weight, the fragrance may not be solubilized in a transparent state. On the other hand, when the amount is more than 1.4 parts by weight, the amount of the reduced amount of the surfactant is too small, and the effect of reducing the surfactant may not be sufficiently obtained.

  In the solubilized composition of the present invention, in addition to the above-described components, other components may be blended as necessary within a range not impairing the effects of the present invention.

  For example, you may mix | blend an oil-soluble organic solvent as needed. Examples of the oil-soluble organic solvent include isoparaffin, paraffin, limonene, pinene, triethyl citrate, benzyl benzoate, isopropyl myristate, triacetin, and silicon.

  If necessary, sequestering agents, antioxidants, deodorants, disinfectants, UV absorbers, pH adjusters, cationic surfactants, amphoteric surfactants, cloudiness agents, insecticide components, Insect repellent ingredients, repellent ingredients, pigments, sweeteners and the like may be incorporated.

  The solubilized composition of the present invention comprises a slightly water-soluble substance, the aforementioned solubilization accelerator composition, an anionic surfactant, a nonionic surfactant, an aqueous solvent, and other components as required in a predetermined amount ratio. It can be prepared by mixing with. The solubilization accelerator composition may be prepared separately by the above-described method, or each component of the solubilization accelerator composition may be used at a predetermined quantitative ratio when preparing the solubilization composition. It may be prepared by mixing. The solubilized composition of the present invention can be produced by a simple method of mixing and stirring without requiring a special apparatus.

The solubilized composition of the present invention can be used in combination with a fragrance base, a cosmetic base, a pharmaceutical base or a quasi-drug base to produce a product such as a fragrance, cosmetic, pharmaceutical or quasi-drug. Can be manufactured. A desirable method for preparing such a product is to mix the base in a predetermined quantitative ratio during or after the preparation of the solubilized composition described above.
Ingredients acceptable as a fragrance base, cosmetic base, pharmaceutical base or quasi-drug base include, for example, fats and oils, waxes, hydrocarbons, fatty acids, alcohols, esters, polyhydric alcohols, fluoro oils, Moisturizer, film agent, thickener, gelling agent, inorganic minerals, powder, sequestering agent, monosaccharide, oligosaccharide, amino acid, vitamin, peptide, protein, collagen, ceramide, plant extract, organic amine , Macromolecules, antioxidants, antioxidant aids, skin nutrients, cell activators, blood flow promoters, whitening agents, hair restorers, skin roughening agents, anti-wrinkle agents, astringents, anti-inflammatory agents, pharmacologically active ingredients , UV absorber, organic solvent, silicon, enzyme, warming sensation, cooling sensation, menthol, deodorant, antiseptic, disinfectant, disinfectant, pH adjuster, surfactant, defoaming agent, insecticidal component , Insect repellent, repellent, cloudiness agent, stabilizer, Hamazai, dyes, perfumes, essential oils, sweeteners and the like, can be used as needed.

Examples of the fragrance containing the solubilized composition of the present invention include an aqueous liquid fragrance, a spray fragrance, a bead fragrance using a water absorbent resin, and the like.
The fragrance of the present invention is stored in a container provided with a liquid-absorbing member for sucking up an aqueous liquid fragrance that has been widely used, and a volatilization member for volatilizing the sucked-up aqueous liquid fragrance. It can be used in the form of a liquid fragrance. The liquid-absorbing member and the volatilizing member are usually composed of a fibrous material such as natural fibers such as plant fibers and pulp; synthetic fibers such as rayon, polyester, polyethylene terephthalate, polyethylene, and polypropylene; or mixed fibers thereof. For example, containers such as those disclosed in JP-A-9-187495 and JP-A-2001-225484 can be used. Further, for example, a container provided with a member in which a liquid absorbing member and a volatilization member are integrated as shown in JP2003-102825A and JP2003-320005A may be used.
The fragrance of the present invention can be used in rooms, entrances, toilets, cars and the like. By using the fragrance of the present invention, a desired fragrance can be imparted to the living space.

Examples of cosmetics comprising the solubilized composition of the present invention include cosmetics such as perfume, eau de cologne, lotion, emulsion, cleansing, sunscreen agent, after-shave lotion, deodorant, body lotion; hair tonic, hair styling agent, hair colon, etc. The cosmetics for hair etc. can be illustrated.
Examples of toiletry products made of the solubilized composition of the present invention include clothes deodorant sprays, clothes antistatic agents, toilet cleaners, residential cleaners, floor waxes and the like.
Examples of pharmaceutical products comprising the solubilized composition of the present invention include medicinal cosmetics, medicated lotions and the like.
Examples of quasi drugs comprising the solubilized composition of the present invention include liquid bath agents, mouthwashes, repellents and the like. Examples of repellents include mist spray type and aqueous liquid type.

  EXAMPLES Hereinafter, although this invention is demonstrated more concretely using an Example, this invention is not limited at all by these.

[Examples 1 to 8]
A solubilization accelerator composition was prepared according to the formulation shown in Table 1. The compounding quantity in a table | surface is shown by the mass%.

[Examples 9 to 13, Comparative Examples 1 to 3]
A blended fragrance solubilized composition was prepared according to the blending formulation shown in Table 2, and the appearance properties immediately after blending were observed visually. The results are shown in Table 2.

[Examples 14 to 16, Comparative Examples 4 to 8]
Limonene-solubilized compositions were prepared according to the formulation shown in Table 3, and the appearance properties immediately after the formulation were observed visually. The results are shown in Table 3.

[Example 17]
Aqueous liquid fragrances were prepared according to the recipe shown in Table 4.

[Example 18]
A deodorizing spray for clothing was prepared according to the formulation shown in Table 5.

[Example 19]
A mouthwash was prepared according to the formulation shown in Table 6.

[Example 20]
A liquid bath preparation was prepared according to the formulation shown in Table 7.

  By using the solubilization accelerator and the solubilization accelerator composition of the present invention, even when stored for a long time, excellent transparency stability, good product image, high safety, and high evaluation in the market Solubilized compositions are provided. The solubilized composition of the present invention is suitably used as a fragrance, a cosmetic, a toiletry product, a pharmaceutical product, a quasi-drug, and the like.

Claims (15)

A solubilization accelerator for a poorly water-soluble substance, which is a fragrance or a repellent used in a fragrance, containing gluconate as an active ingredient.   The gluconate is one or more selected from the group consisting of sodium gluconate, potassium gluconate, calcium gluconate, magnesium gluconate, manganese gluconate, zinc gluconate, iron gluconate and copper gluconate. The solubilization promoter according to claim 1. A solubilization accelerator composition comprising the solubilization accelerator according to claim 1 or 2 and an aqueous solvent.   The solubilization promoter composition according to claim 3, further comprising at least one of an auxiliary salt and a preservative. The solubilization promoter composition according to claim 4 , wherein the auxiliary salt is one or more selected from the group consisting of sodium citrate, potassium citrate and sodium malate. The solubilization promoter composition according to claim 4 or 5 , wherein the preservative is one or more selected from the group consisting of potassium sorbate and sodium benzoate. A solubilization accelerator composition according to any one of claims 3 to 6 , an anionic surfactant, a nonionic surfactant , a poorly water-soluble substance and an aqueous solvent which are fragrances or repellents used in fragrances. A solubilized composition containing. The solubilized composition of Claim 7 whose sum total of an anionic surfactant and a nonionic surfactant is 0.3-5 mass parts with respect to 1 mass part of hardly water-soluble substances. The solubilized composition according to claim 7 or 8 , wherein the content of the solubilization accelerator in the composition is 0.01 to 2% by mass. The solubilized composition according to any one of claims 7 to 9 , wherein the content of the anionic surfactant in the composition is 0.05 to 20% by mass. The solubilized composition according to any one of claims 7 to 10 , wherein the anionic surfactant is a dialkylsulfosuccinate. The content of the nonionic surfactant in the set Narubutsu is 0.05 to 20 wt%, the solubilizing composition of any one of claims 7-11. Nonionic surfactants, polyoxyethylene alkyl ethers, selected from the group consisting of polyoxyethylene polyoxypropylene alkyl ether and polyoxyethylene hardened castor oil is one or more of claims 7 to 12 The solubilized composition of any one of Claims. A fragrance comprising the solubilized composition according to any one of claims 7 to 13 , further comprising a base acceptable for the fragrance. Use of gluconate as a solubilization accelerator for poorly water-soluble substances that are fragrances or repellents used in fragrances .