JP6026540B2 - 種々の原因の末梢性潰瘍の治療用組成物 - Google Patents
種々の原因の末梢性潰瘍の治療用組成物 Download PDFInfo
- Publication number
- JP6026540B2 JP6026540B2 JP2014530203A JP2014530203A JP6026540B2 JP 6026540 B2 JP6026540 B2 JP 6026540B2 JP 2014530203 A JP2014530203 A JP 2014530203A JP 2014530203 A JP2014530203 A JP 2014530203A JP 6026540 B2 JP6026540 B2 JP 6026540B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- anthocyanoside
- cypress extract
- extract
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
末梢性潰瘍は、幾つかの症状を共通に有するものの、外傷性要因あるいは代謝性要因のものか、例えば、糖尿病性潰瘍、あるいは、手足の静脈閉塞に起因する潰瘍、床ずれ、ならびにそれらに関連する皮膚感染であるかによって、異なる病因を有している。幾つかは、末梢性の微小循環ならびに血液循環に関係しており、そして、掻痒の結果の引掻き、または偶発的な要因に起因して結果として浮腫を伴う中位および細い動脈の閉塞を引き起こすとともに、結果として生じる細菌性、および/または真菌性感染により治癒するには遅い病変に至る、動脈硬化と主に結びついている。
純粋な形態のアントシアノシドの重亜硫酸付加物、または、それらを含む抽出物は、元のアントシアノシドよりも優れた生物学的活性を有することを見出した。
a)純粋な形態のアントシアノシドの重亜硫酸付加物または、それらを含む抽出物:
b)エキナセア種(Echinacea sp)の脂溶性抽出物;ならびに、
場合によって、
c)血管作動作用を有する物質、
を含む組成物に関する。
a)アントシアノシドの重亜硫酸付加物または、それらを含む抽出物:0.05〜2%、好ましくは、0.5%〜1%;
b)0.01〜1%、好ましくは、0.05〜0.3%のエキナセア種の脂溶性抽出物;ならびに、場合により、
c)0.2〜1%のビスナジンまたはエスクロシド、好ましくは、0.5%の含有率のビスナジン。
下肢の静脈うっ血に起因する潰瘍を患っているが、その他の血管障害を併発していない、50名の患者(各群10名)が、研究に含まれていた。
Claims (8)
- 潰瘍ならびに外傷の治療用の局所投与に適する剤形に製剤化されている組成物であり、
該組成物は、
a)セイヨウスノキ抽出物に由来する、アントシアノシドの重亜硫酸付加物:
b)エキナセア アングスティフォリア、または、ムラサキバレンギクの脂溶性抽出物;ならびに、
場合により、
c)ビスナジンおよび/またはエスクロシド
を含み、
前記a)セイヨウスノキ抽出物に由来する、アントシアノシドの重亜硫酸付加物は、
該組成物中において、セイヨウスノキ抽出物に由来する、純粋なアントシアノシドから、系内で形成される、重亜硫酸付加物である; あるいは、
該組成物中において、セイヨウスノキ抽出物中に含まれる、アントシアノシドから、系内で形成される、重亜硫酸付加物である
ことを特徴とする、組成物。 - セイヨウスノキ抽出物に由来する、アントシアノシドの含有率36±5%を有する、セイヨウスノキ抽出物を0.05〜2%、ならびに、前記セイヨウスノキ抽出物の質量の約半分の質量の重亜硫酸塩;
0.01〜1%のエキナセア アングスティフォリア、または、ムラサキバレンギクの脂溶性抽出物;ならびに、
場合によって、
0,1〜1%のビスナジンおよび/またはエスクロシド
を含有する
ことを特徴とする、請求項1に記載の組成物。 - セイヨウスノキ抽出物に由来する、アントシアノシドの含有率36±5%を有する、セイヨウスノキ抽出物を0.5〜1%、ならびに、前記セイヨウスノキ抽出物の質量の約半分の質量の重亜硫酸塩;
0.05〜0.3%のエキナセア アングスティフォリア、または、ムラサキバレンギクの脂溶性抽出物;ならびに、
場合によって、
0,1〜1%のビスナジンおよび/またはエスクロシド
を含有する
ことを特徴とする、請求項1に記載の組成物。 - 前記腫瘍ならびに外傷の治療用の局所投与に適する剤形は、水性ゲル、水/オイル エマルジョン、閉塞性製剤(occlusive formulation)からなる群から選択される
ことを特徴とする、請求項1〜3のいずれか一項に記載の組成物。 - 放射線療法により誘発される放射線皮膚炎、または、潰瘍性痔核の治療に使用するための、請求項1〜4のいずれか一項に記載の組成物。
- 放射線性皮膚炎、または、下肢の静脈うっ血に起因する潰瘍の治療に使用するための、請求項1〜4のいずれか一項に記載の組成物。
- 糖尿病性潰瘍、静脈うっ血に起因する手足の潰瘍、放射線に起因する潰瘍、あるいは、床ずれの治療に使用するための、請求項1〜4のいずれか一項に記載の組成物。
- 潰瘍ならびに外傷の治療用の局所投与用組成物の調製における、セイヨウスノキ抽出物に由来する、アントシアノシドの重亜硫酸付加物の使用であって、
前記セイヨウスノキ抽出物に由来する、アントシアノシドの重亜硫酸付加物は、
該組成物中において、セイヨウスノキ抽出物に由来する、純粋なアントシアノシドから、系内で形成される、重亜硫酸付加物である; あるいは、
該組成物中において、セイヨウスノキ抽出物中に含まれる、アントシアノシドから、系内で形成される、重亜硫酸付加物である
ことを特徴とする、使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2011A001671 | 2011-09-16 | ||
IT001671A ITMI20111671A1 (it) | 2011-09-16 | 2011-09-16 | Composizioni per il trattamento di ulcere periferiche di varia origine |
PCT/EP2012/067893 WO2013037859A1 (en) | 2011-09-16 | 2012-09-13 | Compositions for the treatment of peripheral ulcers of various origins |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2014526487A JP2014526487A (ja) | 2014-10-06 |
JP6026540B2 true JP6026540B2 (ja) | 2016-11-16 |
Family
ID=44907960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014530203A Expired - Fee Related JP6026540B2 (ja) | 2011-09-16 | 2012-09-13 | 種々の原因の末梢性潰瘍の治療用組成物 |
Country Status (21)
Country | Link |
---|---|
US (3) | US9278084B2 (ja) |
EP (1) | EP2755670B1 (ja) |
JP (1) | JP6026540B2 (ja) |
KR (1) | KR101996319B1 (ja) |
CN (1) | CN103874499B9 (ja) |
AR (1) | AR087879A1 (ja) |
AU (1) | AU2012307406B2 (ja) |
BR (1) | BR112014005966A2 (ja) |
CA (1) | CA2848570C (ja) |
DK (1) | DK2755670T3 (ja) |
ES (1) | ES2577405T3 (ja) |
HU (1) | HUE028120T2 (ja) |
IL (1) | IL231498B (ja) |
IT (1) | ITMI20111671A1 (ja) |
MX (1) | MX347245B (ja) |
PL (1) | PL2755670T3 (ja) |
PT (1) | PT2755670E (ja) |
RU (1) | RU2619853C2 (ja) |
SG (1) | SG11201400617UA (ja) |
SI (1) | SI2755670T1 (ja) |
WO (1) | WO2013037859A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2014292541B2 (en) * | 2013-07-14 | 2018-11-15 | Asiros A/S | Alkaloid compositions from ribes species to treat conditions assosiated with mitochondrial function or inhibition of PDE4, PDE5 and IKK-Beta |
CN103961482A (zh) * | 2014-04-23 | 2014-08-06 | 湖州康企药业有限公司 | 一种治疗皮炎的天然药物 |
ITUB20160672A1 (it) * | 2016-02-11 | 2017-08-11 | Mireno Leoni | Composizione farmaceutica per il trattamento della disidrosi |
KR101892865B1 (ko) | 2017-08-16 | 2018-08-28 | 계명대학교 산학협력단 | 마퀴베리를 유효성분으로 함유하는 아토피성 피부염 예방 또는 치료용 조성물 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1589294A (en) * | 1976-09-08 | 1981-05-13 | Inverni Della Beffa Spa | Pharmaceutical compositions containing anthocyanidines |
US4376781A (en) * | 1978-02-27 | 1983-03-15 | Inverni Della Beffa S.P.A. | Pharmaceutical compositions |
GB8518289D0 (en) * | 1985-07-19 | 1985-08-29 | Inverni Della Beffa Spa | Obtaining proanthocyanidine a2 |
IT1231725B (it) * | 1989-08-11 | 1991-12-21 | Inverni Della Beffa Spa | Procedimento per la preparazione di estratti ad alto contenuto in antocianosidi. |
DK0464298T3 (da) * | 1990-07-05 | 1995-11-13 | Indena Spa | Echinacea-ekstrakter, fremgangsmåde til fremstilling deraf og formuleringer, der indeholder dem |
IT1255029B (it) * | 1992-05-11 | 1995-10-13 | Paolo Morazzoni | Formulazioni farmaceutiche orali contenenti antocianosidi |
IT1270602B (it) * | 1994-07-12 | 1997-05-07 | Indena Spa | Formulazioni a base di esculoside e loro uso in campo farmaceutico e cosmetico |
US6224871B1 (en) * | 1998-03-11 | 2001-05-01 | Reliv International, Inc. | Dietary supplement for nutritionally promoting healthy joint function |
US6780442B2 (en) * | 2000-08-31 | 2004-08-24 | Hauser, Inc. | Efficient method for producing compositions enriched in anthocyanins |
NZ515182A (en) * | 2001-10-31 | 2004-03-26 | Brightwater Horticulture Ltd | Extraction of biologically active compounds from plant material using acid and antioxidant |
US20030152610A1 (en) * | 2002-01-28 | 2003-08-14 | David Rolf | Cosmetic patch |
US8337914B2 (en) * | 2002-02-27 | 2012-12-25 | Access Business Group International Llc | Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation |
RU2203082C1 (ru) * | 2002-07-22 | 2003-04-27 | Государственное учреждение Тверская государственная медицинская академия | Способ лечения язвенно-эрозивных поражений гастродуоденальной зоны в сочетании с артериальной гипертензией |
ITMI20032287A1 (it) * | 2003-11-24 | 2005-05-25 | Indena Spa | Composizioni per il trattamento delle affezioni del cavo orale e delle prime vie respiratorie |
ITMI20042414A1 (it) * | 2004-12-17 | 2005-03-17 | Indena Spa | Formulazione per il trattamento di affezioni delle prime vie respiratorie |
TWI286941B (en) * | 2005-07-27 | 2007-09-21 | Anagen Therapeutics Inc | Stabilized pharmaceutical and cosmetic composition of catechins or derivatives thereof |
GB2428952B (en) | 2005-07-30 | 2010-10-06 | Hewlett Packard Development Co | Digital pen and paper system |
US7763289B2 (en) * | 2005-09-01 | 2010-07-27 | JoAl's Products, LLC | Topical turmeric skin care products |
US7303772B2 (en) * | 2005-11-10 | 2007-12-04 | Olalde Rangel Jose Angel | Synergistic phytoceutical compositions |
EP1882473A1 (en) * | 2006-07-28 | 2008-01-30 | Indena S.P.A. | Use of anthocyanosides to prepare formulations for the treatment of mucositis induced by antitumoral drugs |
EP2937093B1 (en) * | 2008-07-22 | 2018-07-04 | Izun Pharmaceuticals Corporation | Topical anti-inflammatory combination |
-
2011
- 2011-09-16 IT IT001671A patent/ITMI20111671A1/it unknown
-
2012
- 2012-09-13 MX MX2014003051A patent/MX347245B/es active IP Right Grant
- 2012-09-13 PT PT127700011T patent/PT2755670E/pt unknown
- 2012-09-13 DK DK12770001.1T patent/DK2755670T3/en active
- 2012-09-13 PL PL12770001.1T patent/PL2755670T3/pl unknown
- 2012-09-13 CA CA2848570A patent/CA2848570C/en not_active Expired - Fee Related
- 2012-09-13 SG SG11201400617UA patent/SG11201400617UA/en unknown
- 2012-09-13 JP JP2014530203A patent/JP6026540B2/ja not_active Expired - Fee Related
- 2012-09-13 KR KR1020147006806A patent/KR101996319B1/ko active IP Right Grant
- 2012-09-13 EP EP12770001.1A patent/EP2755670B1/en active Active
- 2012-09-13 US US14/342,618 patent/US9278084B2/en not_active Expired - Fee Related
- 2012-09-13 CN CN201280044588.XA patent/CN103874499B9/zh not_active Expired - Fee Related
- 2012-09-13 RU RU2014109796A patent/RU2619853C2/ru active
- 2012-09-13 ES ES12770001.1T patent/ES2577405T3/es active Active
- 2012-09-13 HU HUE12770001A patent/HUE028120T2/en unknown
- 2012-09-13 SI SI201230613A patent/SI2755670T1/sl unknown
- 2012-09-13 BR BR112014005966A patent/BR112014005966A2/pt not_active Application Discontinuation
- 2012-09-13 WO PCT/EP2012/067893 patent/WO2013037859A1/en active Application Filing
- 2012-09-13 AU AU2012307406A patent/AU2012307406B2/en not_active Ceased
- 2012-09-14 AR ARP120103397A patent/AR087879A1/es unknown
-
2014
- 2014-03-13 IL IL231498A patent/IL231498B/en active IP Right Grant
-
2015
- 2015-11-06 US US14/935,036 patent/US9526716B2/en active Active
-
2016
- 2016-10-18 US US15/296,533 patent/US10149877B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2632475B1 (en) | Compositions for the treatment of peripheral ulcers of various origins | |
US10149877B2 (en) | Compositions for the treatment of peripheral ulcers of various origins | |
JP2013060455A (ja) | ハチ毒を有効成分とする組成物 | |
KR20140104823A (ko) | 당뇨병성 창상의 예방 또는 치료용 약학 조성물 | |
CA2880439C (en) | Use of procyanidin compositions in the treatment of diabetic foot ulcers, pressure ulcers and venous leg ulcers | |
US20130045269A1 (en) | Formulations and methods for wound treatment | |
US10905729B1 (en) | Formulations and methods for wound treatment | |
US20200390841A1 (en) | Compositions and methods for treating wounds | |
RU2589257C1 (ru) | Зверкалипт | |
LT4880B (lt) | Pelkinės vingiorykštės preparato gamybos būdas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A529 | Written submission of copy of amendment under article 34 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A529 Effective date: 20140313 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20140523 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150806 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160517 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160816 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160913 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20161012 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6026540 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |