JP6018636B2 - マルチチャネルフローセル - Google Patents
マルチチャネルフローセル Download PDFInfo
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0636—Focussing flows, e.g. to laminate flows
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
- G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0031—General constructional details of gas analysers, e.g. portable test equipment concerning the detector comprising two or more sensors, e.g. a sensor array
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
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Description
しかし、多くの状況において、より高いスループットが必要となるので、センサ表面上にはさらに多くの検出スポットが求められる。
1. ポート38iからポート38aへ、例えば緩衝液などの保護流体を流しながら、ポート36iからポート36aに活性化流体を流すことによる第1のセクション58aの活性化(図13a)
2. フローチャネル34a〜iに沿ってリガンド溶液を流すこと、それによりリガンドは各チャネルとSPR検出線9bに沿って検出スポットを形成する第1のセクション58aの交差領域で固定化される(図13b)
3. ポート38iからポート38aへ、例えば緩衝液などの保護流体を流しながら、ポート36iからポート36aに非活性化流体を流すことによる第1のセクション58aの非活性化(図13c)
4. 適宜、第2のセクション58bに段階aからcを繰り返し、相応してSPR検出線9aに沿った検出スポットを形成する前記セクションの交差領域でリガンドを固定化すること(図13a〜c)。或いは、第2のセクション58bの検出スポットは基準スポットとして空白にしておく。
5. SPR検出線9a及び9bに沿った検出スポット13の相互作用レスポンスを記録しながら、フローチャネル34a〜iに沿ってアナライト溶液を流すこと(図13d)
6. ポート36i及び38iからポート36a及び38aに再生成流体を流すことによってすべての検出スポット13において同時に固定化されたリガンドを再生成すること(図13e)
図14a及び図14bは、交差するフロー経路の境界面位置60が、例えば1以上の追加の交差する検出線9cを流体力学的に処理するために、2つの流体の相対流量を制御することによって変位される一実施形態を示す。そのような境界面の流体力学的な位置決めを達成するさまざまな方法は、例えば、参照によって全体をここに援用する、米国特許第7811515号、米国特許第7219528号、米国特許第7015043号、及び国際公開第2003102580号に開示されている。
2 フローチャネル
3 アナライト
4 キャプチャ分子(リガンド)
5 照明ユニット
6 p偏光
7 プリズム
8 境界面
9 SPR曲線
10 反射光ビーム
11 光検出ユニット
12 SPRセンサ表面
13 検出領域
14 くさび形ビーム
15 光源
16 くさび形成光学系
17 2次元光検出器ユニット
18 検出スポット
19 線形の検出領域
20 フローチャネル
21 フローセルユニット
22 流体ポート
23 フローセル構成
24 流体管
25 流体制御システム
26 バルブセクション
27 壁
28 力制御要素
29 連結ユニット
30 連結力位置
31 作動装置
32 スプリング要素
33 入口−出口ペア
34 層流チャネル
Claims (10)
- 閉フローセル構成を形成するために平坦な蓋表面に連結されるフローセルユニットであって、3以上の隣接する延長フローチャネルを画定する弾性材料の突き出た壁を持つ上面を備え、各フローチャネルは第1の流体ポート及び第2の流体ポートを備え、
隣接するフローチャネルを分離する前記壁は、低い高さのバルブセクションを備え、それによりフローセルと前記蓋表面との間の連結力を、それぞれ開いた連結状態及び閉じた連結状態に制御することによって、前記延長フローチャネルと交差するフロー経路を選択的に開閉できるようにする、フローセルユニット。 - 一方又は両方の連結状態において、前記壁をさらに圧迫するために必要な前記連結力を段階的に高めるように配置された弾性材料の1以上の力制御要素を備える、請求項1記載のフローセルユニット。
- 交差するフロー経路に沿って交差する層流チャネルを提供するように配置された1以上の交差するように配置された入口−出口ペアを備える、請求項1又は請求項2記載のフローセルユニット。
- 閉フローセル構成を形成するために平坦な蓋表面に連結される請求項1乃至3のいずれか1項に記載のフローセルユニットと、前記フローセルユニットの前記第1及び第2の流体ポートに接続された流体管と、前記流体管を経由する流体のフローを制御するための流体制御システムと、フローセルと前記蓋表面の間の連結力をそれぞれ開いた連結状態及び閉じた連結状態に制御するように配置された連結ユニットとを備える、流体システム。
- 連結ユニットは、前記2つの連結状態に事前定義済みの連結力を供給するように配置された力制御構成を備える、請求項4記載の流体システム。
- 連結力センサを備え、前記連結ユニットは前記力センサからのフィードバックに基づいて事前定義済みの力を印加するように配置される、請求項4記載の流体システム。
- 請求項4乃至6のいずれか1項記載の流体システムを備えるバイオセンサシステム。
- 平坦な蓋表面はSPRセンサ表面である、請求項4乃至6のいずれか1項記載の流体システムを備える、表面プラズモン共鳴(SPR)バイオセンサシステム。
- 前記隣接する延長フローチャネルに交差する前記SPRセンサ表面上の2以上の間隔をあけた線形の検出領域においてSPRレスポンスを記録するように配置された、請求項8記載のSPRバイオセンサシステム。
- 前記全SPRセンサ表面にわたり前記SPRレスポンスを空間的に記録するように配置された、請求項8記載のSPRバイオセンサシステム。
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Application Number | Priority Date | Filing Date | Title |
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SE1100724-2 | 2011-09-30 | ||
SE1100724 | 2011-09-30 | ||
PCT/SE2012/051036 WO2013055281A1 (en) | 2011-09-30 | 2012-09-28 | Multi-channel flowcell |
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JP2014528574A JP2014528574A (ja) | 2014-10-27 |
JP6018636B2 true JP6018636B2 (ja) | 2016-11-02 |
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JP2014533245A Active JP6018636B2 (ja) | 2011-09-30 | 2012-09-28 | マルチチャネルフローセル |
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US (1) | US9958438B2 (ja) |
EP (1) | EP2761295B1 (ja) |
JP (1) | JP6018636B2 (ja) |
WO (1) | WO2013055281A1 (ja) |
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CN105181658B (zh) * | 2014-05-27 | 2018-11-23 | 中央研究院 | 感测装置及应用其的感测系统及感测方法 |
US10084979B2 (en) * | 2016-07-29 | 2018-09-25 | International Business Machines Corporation | Camera apparatus and system, method and recording medium for indicating camera field of view |
CN106841120B (zh) * | 2017-03-31 | 2023-08-25 | 丁利 | 适用于多通道终端反射式光纤spr传感器的流通池 |
TWI695162B (zh) * | 2017-09-28 | 2020-06-01 | 美商伊路米納有限公司 | 流體施配器總成與用於將流體施配至流體匣中的方法 |
JP6731901B2 (ja) * | 2017-09-29 | 2020-07-29 | 株式会社日立ハイテク | 分析装置 |
AU2019337557A1 (en) * | 2018-09-14 | 2021-01-14 | Illumina, Inc. | Flow cells and methods related to same |
WO2020061715A1 (en) * | 2018-09-28 | 2020-04-02 | Nicoya Lifesciences, Inc. | Plasmon resonance system, instrument, and device for measuring molecular interactions |
WO2020234691A1 (en) | 2019-05-17 | 2020-11-26 | Creoptix Ag | Methods for determining kinetic parameters of a reaction between analyte and ligands |
DE102020107645B4 (de) * | 2020-03-19 | 2024-07-18 | Bruker Daltonics GmbH & Co. KG | Betrieb einer Mikrofluidik-Vorrichtung bei der Analyse von Probesubstanzen |
CN114682310B (zh) * | 2020-12-31 | 2023-12-05 | 深圳市真迈生物科技有限公司 | 液路系统、测序系统和方法 |
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SE470347B (sv) * | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system |
US6200814B1 (en) | 1998-01-20 | 2001-03-13 | Biacore Ab | Method and device for laminar flow on a sensing surface |
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US20030186426A1 (en) * | 2000-03-15 | 2003-10-02 | The Regents Of The University Of California | Multichannel flow cell for interacting single optically trapped, DNA molecules with different chemical species |
ATE374162T1 (de) * | 2000-11-02 | 2007-10-15 | Biacore Ab | Ventil dem eine mikrofluide flüssigkeitstransportanordnung integral zugeordnet ist |
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EP1489404A1 (de) | 2003-06-16 | 2004-12-22 | GeSIM Gesellschaft für Silizium-Mikrosysteme mbH | Verfahren zum Herstellen einer 3-D-Mikroskop-Durchflusszelle |
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EP2517024A4 (en) * | 2009-12-22 | 2013-11-06 | Ge Healthcare Bio Sciences Ab | ANALYSIS METHOD WITH ENHANCED MIXING |
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- 2012-09-28 US US14/343,120 patent/US9958438B2/en active Active
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US20140219871A1 (en) | 2014-08-07 |
EP2761295B1 (en) | 2016-02-10 |
US9958438B2 (en) | 2018-05-01 |
EP2761295A4 (en) | 2015-05-27 |
WO2013055281A1 (en) | 2013-04-18 |
EP2761295A1 (en) | 2014-08-06 |
JP2014528574A (ja) | 2014-10-27 |
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