JP6006211B2 - ３員環の縮合エーテルカルバメートおよびその使用 - Google Patents

３員環の縮合エーテルカルバメートおよびその使用 Download PDF

Info

Publication number
JP6006211B2
JP6006211B2 JP2013527348A JP2013527348A JP6006211B2 JP 6006211 B2 JP6006211 B2 JP 6006211B2 JP 2013527348 A JP2013527348 A JP 2013527348A JP 2013527348 A JP2013527348 A JP 2013527348A JP 6006211 B2 JP6006211 B2 JP 6006211B2
Authority
JP
Japan
Prior art keywords
optionally substituted
hiv
alkyl
compounds
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2013527348A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013536871A5 (OSRAM
JP2013536871A (ja
Inventor
ゴーシュ，アルン，ケイ．
シュ，チュン−シャオ
裕明 満屋
裕明 満屋
パルハム，ガース
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of JP2013536871A publication Critical patent/JP2013536871A/ja
Publication of JP2013536871A5 publication Critical patent/JP2013536871A5/ja
Application granted granted Critical
Publication of JP6006211B2 publication Critical patent/JP6006211B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2013527348A 2010-09-02 2011-09-02 ３員環の縮合エーテルカルバメートおよびその使用 Expired - Fee Related JP6006211B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37941410P 2010-09-02 2010-09-02
US61/379,414 2010-09-02
PCT/US2011/050393 WO2012031237A1 (en) 2010-09-02 2011-09-02 Fused tricyclic ether carbamates and their use

Publications (3)

Publication Number Publication Date
JP2013536871A JP2013536871A (ja) 2013-09-26
JP2013536871A5 JP2013536871A5 (OSRAM) 2014-10-16
JP6006211B2 true JP6006211B2 (ja) 2016-10-12

Family

ID=45773291

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013527348A Expired - Fee Related JP6006211B2 (ja) 2010-09-02 2011-09-02 ３員環の縮合エーテルカルバメートおよびその使用

Country Status (5)

Country Link
US (2) US8563597B2 (OSRAM)
EP (1) EP2611295B1 (OSRAM)
JP (1) JP6006211B2 (OSRAM)
CA (1) CA2810005A1 (OSRAM)
WO (1) WO2012031237A1 (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6006211B2 (ja) 2010-09-02 2016-10-12 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ ３員環の縮合エーテルカルバメートおよびその使用
EP3142659B1 (en) * 2014-05-16 2021-03-24 Purdue Research Foundation Hiv-1 protease inhibitors and uses thereof
US11028096B2 (en) 2016-11-09 2021-06-08 Purdue Research Foundation Tricyclic P2-ligand containing potent HIV-protease inhibitors against HIV/AIDS
JOP20180009A1 (ar) 2017-02-06 2019-01-30 Gilead Sciences Inc مركبات مثبط فيروس hiv
TWI766172B (zh) 2018-07-30 2022-06-01 美商基利科學股份有限公司 抗hiv化合物
EP4121042A4 (en) * 2020-03-18 2024-04-17 Purdue Research Foundation Tricyclic p2-ligand containing potent hiv-protease inhibitors
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627165A (en) 1990-06-13 1997-05-06 Drug Innovation & Design, Inc. Phosphorous prodrugs and therapeutic delivery systems using same
IL162574A0 (en) * 2001-12-21 2005-11-20 Tibotec Pharm Ltd Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
EP2491785A1 (en) * 2006-11-21 2012-08-29 Purdue Research Foundation Method and compositions for treating HIV infections
WO2009105782A1 (en) * 2008-02-21 2009-08-27 Sequoia Pharmaceuticals, Inc. Hiv protease inhibitor and cytochrome p450 inhibitor combinations
JP6006211B2 (ja) 2010-09-02 2016-10-12 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ ３員環の縮合エーテルカルバメートおよびその使用

Also Published As

Publication number Publication date
JP2013536871A (ja) 2013-09-26
WO2012031237A1 (en) 2012-03-08
US20130158094A1 (en) 2013-06-20
US20140179754A1 (en) 2014-06-26
WO2012031237A8 (en) 2012-04-26
US8563597B2 (en) 2013-10-22
US9487541B2 (en) 2016-11-08
EP2611295A4 (en) 2015-01-28
CA2810005A1 (en) 2012-03-08
EP2611295A1 (en) 2013-07-10
EP2611295B1 (en) 2017-07-19

Similar Documents

Publication Publication Date Title
JP6006211B2 (ja) ３員環の縮合エーテルカルバメートおよびその使用
KR102771082B1 (ko) 케토아미드계 화합물 및 이의 제조 방법, 약학 조성물과 용도
US20240269108A1 (en) Taxane Analogs for the Treatment of Brain Cancer
CA2373073A1 (en) Cyclic compounds and uses thereof
WO2013019967A1 (en) Modulators of virus assembly as antiviral agents
KR101419320B1 (ko) 2-(치환된-아미노)-벤조티아졸 설폰아미드 ｈｉｖ 프로테아제 저해제
AU2020356484A1 (en) ERK5 degraders as therapeutics in cancer and inflammatory diseases
CA2490239C (en) Substituted 2,4-dihydro-pyrrolo (3, 4-b) -quinolin-9-one derivatives useful as phosphodiesterase inhibitors
EP2307345A1 (en) Nonpeptide hiv-1 protease inhibitors
CN119060066A (zh) 取代的芳基或杂芳基并双环类抑制剂及其制备方法和应用
US9499558B2 (en) Compounds and methods for treating HIV
WO2012092188A1 (en) Hydrogen bond forming p1 ligands and methods for treating hiv
EP2528440A1 (en) Substituted norindenoisoquinolines, syntheses thereof, and methods of use
JP2008519862A (ja) Ｈｉｖ−１カプシド形成のインヒビター：置換アリール・アミノメチル・チアゾール尿素およびその類縁物質
US9617276B2 (en) Compounds and methods for treating AIDS and HIV infections
JP6773035B2 (ja) Ｅｐ２アゴニスト活性を有する化合物
KR20230004549A (ko) Rna 바이러스 감염증, 특히, covid-19를 치료하기 위한 항바이러스성 화합물 및 방법
US9346820B2 (en) HIV-1 protease inhibitors having gem-di-fluoro bicyclic P2-ligands
WO2025015645A1 (zh) 咪唑并[1,2-a]吡嗪类化合物的新应用
Hencken Studies in organic synthesis: Modern organoselenium applications and trioxane-based medicinal chemistry
CN113861176A (zh) 一种黄病毒抑制剂
WO2013050476A1 (en) New apoptosis inducing compounds
WO2017125870A1 (en) Amine derivatives of lupanes with hiv maturation inhibitory activity

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140829

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140829

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20150616

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150714

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20151013

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151116

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160412

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160712

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160809

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160908

R150 Certificate of patent or registration of utility model

Ref document number: 6006211

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees