JP6002816B2 - Oil / vesicle / water emulsion composition and cosmetics containing the same - Google Patents

Description

  The present invention relates to an oil / vesicle / water emulsion composition excellent in moisture transpiration suppression effect, a method for producing the same, and a cosmetic material having a good feeling of use, containing the emulsion composition.

  Among the amphiphilic substances having both hydrophobic and hydrophilic properties, there are those that form a spherical vesicle composed of a bilayer, such as phospholipid. Such closed vesicles are called vesicles or liposomes, and can stably hold a water-soluble component within the closed vesicle or an oily component within the vesicle membrane. For this reason, for example, when a drug is retained and administered into a living body, it is used as a microcapsule in the fields of pharmaceuticals, cosmetics and the like because of its advantages such as suppression of metabolism and maintenance of drug efficacy over a long period of time.

  In the cosmetic field, oil-in-water emulsified cosmetics have been developed in which a large amount of oil is stably blended in order to impart an excellent moisturizing feeling and a good feeling to use. For this reason, it was desired to develop a composition containing a large amount of oil while having the function of a vesicle, but since the oil component can only be held only in the endoplasmic reticulum membrane, the vesicle structure was maintained. It was difficult to add a large amount of oil.

  In recent years, an emulsifying dispersant having a closed vesicle formed of an amphiphilic substance having a self-organizing ability as a main component has been proposed (Patent Documents 1 and 2). According to the present invention, nanoparticles of an amphiphilic substance are attached to the surface of an oily base by van der Waals force, thereby forming a three-phase structure of an aqueous phase, an emulsifying dispersant phase, and an oil phase. It has been shown that coalescence by thermal collision is less likely to occur without causing a decrease in interfacial energy due to compatibility, and the stability of the emulsion is excellent.

JP 2006-239666 A JP 2007-77178 A

However, according to the emulsifying dispersant having the closed vesicle as a main component, it is possible to add a certain amount of oil while maintaining the vesicle structure, but the vesicle attached to the interface film is a nanoparticle. In other words, it was necessary to blend a biopolymer that was made into single particles by a high-pressure emulsification method or the like. When the high-pressure emulsification method is used, the range of use is limited because there is a limitation that the apparatus cost is high and the productivity is low.
Therefore, the object of the present invention is an oil-in-water emulsification that can be produced by a general-purpose production method, can stably blend a large amount of oil useful for the skin, has an excellent effect of suppressing moisture transpiration, and has a good usability. To provide a composition.

  Therefore, as a result of various studies, the present inventor has used an oil component having a certain IOB value, a polyhydric alcohol, and water as an amphiphilic substance, and a vesicle composed of the amphiphilic substance and a specific oil component on the oil-water interface film. By forming, oily particles whose oil content is coated with the vesicles can be formed, a large amount of oil content can be blended, and an emulsified composition with excellent moisture transpiration control effect and good usability can be obtained. The headline and the present invention were completed.

That is, the present invention provides an oil / vesicle / water emulsion composition comprising the following components (A) to (D).
(A) Amphiphile (B) One or more selected from the group consisting of oils having an IOB value of 0.2 to 0.54 and a melting point of 30 ° C. or less (C) Polyhydric alcohol (D Aqueous component

  Moreover, this invention is 1 type (s) or 2 or more types selected from the group which consists of (A) amphiphile, (B) IOB value is 0.2-0.54, and melting | fusing point is 30 degrees C or less. The vesicle-coated oily particles are provided in which the surface of the component (B) not contained in the vesicle is coated with a vesicle composed of a part of the vesicle.

  Furthermore, the present invention provides a cosmetic containing the vesicle-coated oily particles or the oil / vesicle / water emulsion composition.

Furthermore, the present invention provides
(1) The following components (A) to (C) are heated to the phase transition temperature or higher and mixed uniformly.
(A) Amphiphile (B) One or more selected from the group consisting of oils having an IOB value of 0.2 to 0.54 and a melting point of 30 ° C. or lower (C) Polyhydric alcohol (2 ) Heat the aqueous component above the phase transition temperature,
(3) The present invention provides a method for producing an oil / vesicle / water emulsion composition, wherein (1) is added to (2) and mixed uniformly.

  According to the present invention, a vesicle is formed from (A) an amphiphile and a part of (B) oil in the vicinity of the interface on the oil / water interface between the oil and the aqueous component, and the remaining (B) is formed by the vesicle. Vesicle-coated oily particles are formed by covering the surface of the oil. The oil / vesicle / water (O / V / W) emulsion composition containing the vesicle-coated oily particles in the dispersed phase can contain a large amount of oil useful for the skin while taking advantage of the characteristics of the vesicle, It is possible to obtain a composition having an excellent effect of suppressing moisture transpiration and a good feeling upon use. In particular, it is useful as cosmetics, pharmaceuticals and the like.

It is a figure which shows the differential interference microscope image (Example 8) of the O / V / W emulsion composition of this invention which has a structure where the oil component surface was coat | covered with the vesicle. It is a figure which shows the polarization microscope image (Example 8) of the O / V / W emulsion composition of this invention which has a structure where the oil component surface was coat | covered with the vesicle. It is a figure which shows the evaluation result (Example 8, comparative example 7) of the moisture transpiration suppression effect.

The vesicle-coated oil-based particles in the present invention are formed on the oil / water interface between the oil and the aqueous component, and the vesicle is formed from (A) an amphiphile and (B) a part of the oil in the vicinity of the interface. The remaining (B) means oily particles whose surface is covered with oil.
The oil / vesicle / water emulsion composition (hereinafter referred to as O / V / W emulsion composition) in the present invention means an emulsion composition in which an aqueous component is a continuous phase and the vesicle-coated oily particles are a dispersed phase. To do.

  The IOB value in the present invention is an abbreviation of Inorganic / Organic Balance (inorganic / organic ratio), and corresponds to the ratio of the inorganic value of the compound to the organic value of the compound, and the degree of polarity of the organic compound It is an index showing. Specifically, it is expressed as IOB value = inorganic value / organic value.

  Here, for each of the “inorganic value” and “organic value”, for example, “organic value” is 20 for one carbon atom in the molecule, and “inorganic value” is 100 for one hydroxyl group. As described above, “inorganic value” and “organic value” corresponding to various atoms or functional groups are set, and “inorganic value” and “organic value” of all atoms and functional groups in the organic compound. Is integrated to calculate the IOB value of the organic compound (see, for example, Yoshio Koda, “Organic Conceptual Diagram—Basics and Applications”, pages 11-17, published by Sankyo Publishing, 1984).

  The amphiphilic substance (A) used in the present invention means a substance having both hydrophilicity and lipophilicity, and phospholipid, glyceroglycolipid, sphingoglycolipid, sterol, polymer having such properties Surfactant and the like can be mentioned, but any amphiphilic substance capable of forming a vesicle can be used without particular limitation.

Examples of the phospholipid used in the present invention include glycerophospholipid and sphingophospholipid.
Glycerophospholipid is a substance having a glycerophosphoric acid skeleton, and has a fatty acid ester, a long-chain alkyl ether, a vinyl ether or the like as a lipophilic group. Specifically, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphadiylinositol, phosphatidylinositol polyphosphate, phosphatidylglycerol, diphosphatidylglycerol (cardiolipin), phosphatidic acid, lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylserine, lysophosphatidylserine, Examples include phosphatidylinositol, lysophosphatidylglycerol, and lysophosphatidic acid.
Sphingophospholipids have long-chain bases or long-chain fatty acids such as sphingosine and phytosphingosine, and phosphoric acid or phosphonic acid. Ceramide 1-phosphate derivatives (such as sphingomyelin), ceramide 1-phosphonic acid derivatives ( Ceramide aminoethylphosphonic acid and the like).

  Examples of the glyceroglycolipid include sulfoxyribosyl glyceride, diglycosyl diglyceride, digalactosyl diglyceride, galactosyl diglyceride, glycosyl diglyceride and the like.

  Examples of the glycosphingolipid include galactosyl cerebroside, lactosyl cerebroside, ganglioside and the like.

  Examples of sterols include cholesterol, dihydrocholesterol, lanosterol, β-sitosterol, campesterol, stigmasterol, brassicasterol, ergocasterol, fucosterol, and 3β- [N- (N ′, N′-dimethylaminoethyl) carbamoyl. ] Cholesterol and the like.

  As the polymer, N- [1- (2,3-dioleoylpropyl)]-N, N, N-trimethylammonium chloride, N- [1- (2,3-dioleoylpropyl)]-N, N-dimethylamine, N- [1- (2,3-dioleyloxypropyl)]-N, N, N-trimethylammonium chloride, 2,3-dioleyloxy-N- [2- (sperminecarboxamide) Ethyl] -N, N-dimethyl-1-propanaminium trifluoroacetic acid, N- [1- (2,3-ditetradecyloxypropyl)]-N, N-dimethyl-N-hydroxyethylammonium bromide, N- [1- (2,3-dioleyloxypropyl)]-N, N-dimethyl-N-hydroxyethyl ammonium bromide and the like can be mentioned.

  Examples of the surfactant include sorbitan fatty acid ester (sorbitan monolaurate, sorbitan monooleate), polyoxyethylene fatty acid ester (polyoxyethylene sorbitan monooleate), polyoxyethylene derivative (polyoxyethylene hydrogenated castor oil), Nonionic surfactants such as glycerin fatty acid ester and biosurfactant (Alcaligenes Polysacchaides: Alkathylan, manufactured by Hakutosha; mannosyl sorbitol lipid: Surfmellow, manufactured by Toyobo Co., Ltd.) can be mentioned.

Among these amphiphiles, phospholipids are preferable because of the ease of forming an O / V / W emulsion composition, and glycerophospholipids and sphingophospholipids are more preferable.
Particularly preferred are phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol and sphingophospholipid.

  The phospholipid used in the present invention may be a natural product extracted and purified from animals and plants, or may be chemically synthesized, and may be subjected to processing such as hydrogenation or hydroxylation. As a natural product, lecithin, which is an extract / purified product from soybean or egg yolk, is preferable because it is easy to obtain a commercial product.

  Among these lecithins, lecithin containing phosphatidylcholine in an amount of 70% by mass (hereinafter abbreviated as “unit%”) or more is preferable. The content of phosphatidylcholine in lecithin can be analyzed by a method using thin layer chromatography (TLC), high performance liquid chromatography (HPLC), Iatroscan (manufactured by Yatron), or the like. For example, an organic solvent containing phospholipid described in JP-A-2001-186898 is spotted on TLC, developed with chloroform: methanol: acetic acid = 65: 25: 10, sprayed with 50 wt% ethanol sulfate, and after heating A method of analyzing phospholipids with a densitometer is mentioned. In addition to the above method, any method may be used as long as it can measure and calculate the content and content of phosphatidylcholine contained in lecithin. More preferable lecithin is soybean lecithin, egg yolk lecithin, soybean lecithin hydrogenated product, egg yolk lecithin hydrogenated product containing 70% or more of phosphatidylcholine.

  Lecithin containing 70% or more of phosphatidylcholine is commercially available, Coatsome NC-21 (hydrogenated soybean lecithin; manufactured by NOF Corporation), lecinol S-10E, lecinol S-10EX (hydrogenated soybean lecithin; Nikko Chemicals) For example).

  The content of the amphiphilic substance in the O / V / W emulsion composition is preferably 0.0001 to 20% by mass, more preferably 0.0005 to 15%, based on the total amount of the O / V / W emulsion composition. It is mass%, Most preferably, it is 0.001-10 mass%. If it is within this range, the expected sufficient moisturizing effect can be obtained, and the preparation of the O / V / W emulsion composition is easy.

  (B) The oil component having an IOB value of 0.2 to 0.54 and a melting point of 30 ° C. or less (IOB value in parentheses) used in the present invention is isononyl isononanoate (0.2), polyisoisostearate poly Oxyethylene glyceryl (0.2), polyoxyethylene glyceryl trioleate (0.2), propylene glycol dilaurate (0.22), isostearic acid polyoxyethylene lauryl ether (2E.O.) (0.23) , Ethylene glycol distearate (0.23), ethylene glycol dilaurate (0.23), tri (caprylic acid / capric acid / stearic acid) glyceryl (0.23), trimyristate polyoxyethylene trimethylolpropane (0 .23), diethylene glycol distearate (0.24), triisostearate Polyoxyethylene hydrogenated castor oil (0.24), polyoxyethylene glyceryl tristearate (0.24), octyl palmitate (0.24), diethylene glycol diisostearate (0.25), diethylene glycol dioleate (0 .25), neopentyl glycol dicaprate (0.25), propylene glycol dicaprate (0.26), dioctyldodecyl stearoyl glutamate (0.26), polyglyceryl triisostearate (0.26), polyoxytristearate Ethylene trimethylolpropane (0.28), ethylhexyl methoxycinnamate (0.28), isostearyl alcohol (0.29), glyceryl diisostearate (0.29), polyoxyethylene acetate stearate Ruether (3E.O.) (0.29), polyoxyethylene glyceryl tristearate (0.29), dioctyldodecyl lauroyl glutamate (0.29), polyoxyethylene trimethylolpropane distearate (0.3), Polyoxyethylene glyceryl triisostearate (0.3), polyoxyethylene glyceryl trioleate (0.3), polyoxyethylene sorbitol tetraoleate (4EO) (0.31), propylene glycol dicaprylate ( 0.32), triethylene glycol distearate (0.32), polyethylene glycol distearate (0.32), polyoxyethylene lauryl ether stearate (3EO) (0.32), N-lauroyl-L -Di-2-hexyl glutamate Sildecyl (0.33), triethylene glycol diisostearate (0.33), triethylene glycol dioleate (0.33), tri (caprylic / capric) glycerin (0.33), polyoxyethylene sorbitan triisostearate (4E. O. ) (0.33), trimethylolpropane trioctanoate (0.33), polyoxyethylene sorbite tristearate (0.33), diisostearyl malate (0.33), di-2-ethylhexanoic acid Neopentyl glycol (0.34), polyoxyethylene glycerin tristearate (0.34), polyoxyethylene trimethylolpropane trimyristate (0.34), diethylene glycol dilaurate (0.35), polyoxystearate Ethylene stearyl ether (4E.O.) (0.35), tetra-2-ethylhexanoic acid pentaerythritol (0.35), glyceryl tri-2-ethylhexanoate (0.35), distearate polyoxyethylene trimethylol Propane (0.36), triisostearic acid Reoxyethylene hydrogenated castor oil (0.36), octyldodecyl lactate (0.36), polyoxyethylene glyceryl distearate (0.38), methylpentanediol dineopentanoate (0.38), polyoxyethylene monoisostearate Hydrogenated castor oil (0.38), propylene glycol monostearate (0.38), propylene glycol oleate (0.39), polyethylene glycol distearate (0.39), hexyldecyl myristoylmethylaminopropionate (0. 39), propylene glycol monooleate (0.39), propylene glycol isostearate (0.4), polyethylene glycol diisostearate (4EO) (0.4), polyethylene glycol dioleate (0.4), Polyglyceryl stearate (0.4), ethylene glycol monostearate (0.4), lauroyl glutamic acid polyoxyethylene octyldodecyl ether diester (0.4), polyglyceryl diisostearate (0.41), octyldodecyl lactate (0. 41), polyoxyethylene trimethylolpropane distearate (0.42), polyoxyethylene stearyl ether diester (0.42) lauroyl glutamic acid, polyoxyethylene cetyl ether stearate (5E.O.) (0.43), Dineopentanic acid diethylpentanediol (0.44), polyoxyethylene stearyl ether (0.44), dilauric acid triethylene glycol (0.45), di-2-ethylhexanoic acid neopentylglycol (0.47), polyoxyethylene stearyl ether stearate (6E. O. (0.47), polyoxyethylene hydrogenated castor oil (0.47), lipophilic glyceryl monostearate (0.47), polyoxyethylene lauryl ether (5E.O.) (0 .48), polyoxyethylene lauryl ether stearate (5EO) (0.48), polyoxyethylene trimethylolpropane tristearate (0.48), polyoxyethylene cetyl ether (0.49), trio Polyoxyethylene glyceryl oleate (0.5), polyoxyethylene glyceryl tristearate (0.5), polyoxyethylene methylpolysiloxane copolymer (0.5), polyglyceryl distearate (0.51), Polyoxyethylene glyceryl triisostearate (0.51) Polyoxyethylene hydrogenated castor oil (0.51), polyglyceryl diisostearate (0.52), polyethylene glycol dioleate (0.52), polyethylene glycol distearate (0.52), polyglyceryl triisostearate (0.52) , Polyethylene glycol diisostearate (6EO) (0.53), glyceryl palmitate (0.53), polyethylene glycol monostearate (0.53), propylene glycol laurate (0.53), isostearyl glyceryl Examples include ether (0.54), polyethylene glycol dilaurate (0.54), and polyoxyethylene hydrogenated castor oil (0.54) monoisostearate.

  From the viewpoint of feeling of use, an oil component having a preferred IOB value of 0.2 to 0.54 and a melting point of 30 ° C. or less includes isononyl isononanoate, propylene glycol dicaprate, isostearyl alcohol, propylene glycol dicaprate, trioctanoic acid Examples thereof include trimethylolpropane, octyldodecyl lactate, polyglyceryl diisostearate, polyglyceryl triisostearate, isostearyl glyceryl ether, and propylene glycol monoester represented by the following general formula (1).

(In the formula, R ¹ represents a linear or branched, saturated or unsaturated hydrocarbon group having 9 to 23 carbon atoms)

Among these oils, R ^{1 of the} propylene glycol monoester represented by the general formula (1) is a straight chain having 15 to 19 carbon atoms, particularly from the viewpoint of obtaining the effect of suppressing moisture transpiration and the feeling of use. Or a branched, saturated or unsaturated hydrocarbon group is preferable, and propylene glycol isostearate and propylene glycol oleate are preferable.

The content of these oils in the O / V / W emulsion composition is preferably 0.05 to 60% by mass, more preferably 0.1 to 40% by mass, and most preferably 0.1 to 20% by mass. .
If it is in the said range, since the outstanding moisture transpiration suppression effect is acquired and preparation of an emulsion composition is also easy, it is preferable.

  In the O / V / W emulsion composition, (B) an IOB value of 0.20 to 0.54 and a melting point of 30 ° C. or less and an oil component other than an oil component is substantially not included. Although it is preferable, oil components other than the component (B) may be contained as long as they are 5 parts by mass or less with respect to 100 parts by mass of the component (B).

  The (A) amphiphile and (B) IOB value of the present invention is 0.20 to 0.54, and the content mass ratio [A / B] of the oil having a melting point of 30 ° C. or less is an excellent moisture transpiration effect and From the point of obtaining a good feeling of use, 1 / 0.05 to 1/2000 is preferable, more preferably 1 / 0.1 to 1/100, and particularly preferably 1 / 0.5 to 1/50. .

  In the O / V / W emulsion composition of the present invention, (C) a polyhydric alcohol is further used in combination in order to improve the dispersibility of the amphiphile and improve the feeling of use. Preferred polyhydric alcohols include ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol (average molecular weight less than 1000), propylene glycol, dipropylene glycol, polypropylene glycol (average molecular weight: less than 1000), glycerin, diglycerin, polyglycerin, Examples include isoprene glycol, 1,2 pentanediol, 1,3-butylene glycol, hexylene glycol and the like. Of these, isoprene glycol, 1,2 pentanediol, 1,3-butylene glycol, dipropylene glycol, and hexylene glycol are particularly preferable.

(C) 1-10 mass% is preferable, as for content in the O / V / W emulsion composition of a polyhydric alcohol, More preferably, it is 2-9 mass%, More preferably, it is 3-8 mass%. .
Within this range, the vesicles have good dispersibility, no separation / aggregation, etc., and they are excellent in feeling of use and smoothness.

  In the emulsified composition of the present invention, the mass ratio [A / C] of (A) amphiphile and (C) polyhydric alcohol is not produced by separation / aggregation of the O / V / W emulsified composition. From the point of good quality, 1: 12000-4: 1 are preferable, More preferably, it is 1: 5200-1: 3.5.

  The emulsified composition of the present invention contains (D) an aqueous component (excluding the (C) polyhydric alcohol). Examples of the aqueous component include water, alcohol, water-soluble polymer, hydroxide and the like. The content of the aqueous component in the emulsified composition is preferably 20 to 98.9499% by mass, more preferably 36 to 97.8895% by mass, and still more preferably 62 to 96.899% by mass.

The alcohol of the aqueous component is a compound having a hydroxyl group, excluding the (C) polyhydric alcohol, and can be blended as an optional component. Preferred examples include lower alcohols having 2 to 8 carbon atoms, such as ethanol, propanol, isopropanol, butyl alcohol, isobutyl alcohol, pentanol, hexanol, heptanol, octanol, phenol, cresol, cyclohexanol, methylcyclohexanol, benzyl alcohol, phenoxyethanol. Etc.
When mix | blending the said alcohol in an O / V / W emulsion composition, 5 mass% or less is preferable in the said emulsion composition, More preferably, it is 3 mass% or less. If it is in the said range, the O / V / W emulsion composition of this application has no influence on formation, and is preferable.

The water-soluble polymer of the aqueous component can be blended as an optional component, such as carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, xanthan gum, hydroxypropylmethylcellulose, polyacrylamide, (Na acrylate / acryloyl dimethyl taurine Na) Examples thereof include copolymers, hyaluronic acid and alkali metal salts thereof.
When mix | blending the said water-soluble polymer in an O / V / W emulsion composition, 0.1-2 mass% is preferable in the said emulsion composition, More preferably, it is 0.1-1 mass. %.
If it is in the said range, a usability | use_condition is favorable and the moisture evaporation suppression effect is acquired and it is preferable.

The aqueous component hydroxide can be blended as an optional component, and examples thereof include metal hydroxide salts such as potassium hydroxide and calcium hydroxide.
When mix | blending the said hydroxide in an O / V / W emulsion composition, 1 mass% or less is preferable in the said emulsion composition, More preferably, it is 0.5 mass% or less. If it is in the said range, there will be no influence on formation of the O / V / W emulsion composition of this application, and it is preferable.

The O / V / W emulsion composition of the present invention is not simply a form in which oil is emulsified with an amphiphilic substance, but an emulsion composition in which an aqueous component is a continuous phase and vesicle-coated oily particles are a dispersed phase. is there. Here, the vesicle-coated oily particles are formed on the oil-water interface between the oil component and the aqueous component, and the vesicle is formed from (A) an amphiphilic substance and (B) a part of the oil component in the vicinity of the interface, and the vesicles remain. (B) Oily particles with the oily surface covered.
By adopting an O / V / W emulsification system containing the vesicle-coated oily particles in the dispersed phase, it becomes an emulsified composition that stably contains a large amount of oil, and has an excellent moisture transpiration control effect and excellent usability. It is thought that The formation of such an emulsification system can be confirmed by a differential interference microscope image and a polarization microscope image.

  The average particle size of vesicles formed on the oil / water interface of the present invention is preferably in the range of 0.5 to 10 μm, more preferably in the range of 1 to 5 μm from the viewpoint of production efficiency. Further, the average particle size of the vesicle-coated oily particles is not particularly limited as long as the vesicle is uniformly coated on the oil surface, but it is preferable to adjust to the range of 5 to 80 μm from the viewpoint of production efficiency, and more preferable. Is in the range of 10-60 μm, most preferably 15-40 μm. The average particle diameter is a value obtained by reading the particle diameter in the same field of the differential interference micrograph for any 20 particles in an arbitrary field of view, calculating from the arithmetic average of the diameters of all the particles that can be read, and rounding off the decimals. It was.

  In order to produce the O / V / W emulsion composition of the present invention, it comprises (A) an amphiphilic substance and (B) a part of oil in the vicinity of the interface on the oil / water interface between the oil and the aqueous component. It is necessary to form vesicles. Therefore, the O / V / W emulsified composition of the present invention (1) (A) amphiphile, (B) oil and (C) polyhydric alcohol is heated to the phase transition temperature or higher and mixed uniformly. Thereafter, (2) mixing with an aqueous component at a phase transition temperature or higher and then (3) cooling to the phase transition temperature or lower for production.

  When a preferred phospholipid is used as an amphiphilic substance, in order to efficiently form the O / V / W emulsion composition of the present invention, (1) (A) an amphiphilic substance, (B) an oil component and ( C) The polyhydric alcohol is heated in the range of 70 to 90 ° C. and uniformly mixed, and then mixed with the aqueous component in the range of 70 to 90 ° C. (preferably at the same temperature as the oily component). ) A method of cooling to 40 ° C. or lower for production.

  (A) Amphiphile, (C) Polyhydric alcohol and (D) Aqueous component are mixed at or above the phase transition temperature to prepare vesicles (liposomes), and then used in the present invention at or below the phase transition temperature (B ) When an oil component is added and mixed, a composition in which the vesicle and the oil component are separately dispersed is obtained, and the vesicle cannot form oily particles coated with the oil component.

  In particular, when the amphiphile is a phospholipid, the phase transition temperature varies greatly depending on the length of the fatty acid chain constituting the phospholipid, the degree of unsaturation, the type of hydrophilic group, etc., but the movement of the acyl chain is suppressed below the phase transition temperature. It is in the form of a gel with no fluidity and becomes a liquid crystal state with increased fluidity above the phase transition temperature. Therefore, it is considered that the O / V / W emulsion composition of the present invention can be efficiently formed by setting the phase transition temperature or higher.

  The phase transition temperature is a temperature when changing from a gel state to a liquid crystal state, and the measurement is performed using a differential scanning calorimeter (DSC), specifically, DSC 120 (manufactured by Seiko Denshi Kogyo Co., Ltd.). The temperature at the top of the endothermic peak observed in the obtained DSC temperature rise curve can be used as the phase transition temperature.

  The formulation stability of the vesicle-coated oily particles is high, and after the vesicle-coated oily particles are formed, the O / V / W emulsion composition of the present invention is oily, organic acids, alkalis, surfactants, UV absorbing. In a composition containing ingredients commonly used in agents, powders, pigments, dyes, antiseptic / antifungal agents, antioxidants, chelating agents, thickeners, fragrances, and pharmaceuticals, quasi drugs, cosmetics, etc. In the range which does not impair the effect of this invention, it can mix | blend suitably. These are preferably applied as skin external preparations such as emulsions, creams, gels, etc., especially for cosmetics and pharmaceuticals.

  The dosage form of the cosmetic containing the O / V / W emulsion composition of the present invention is not particularly limited. However, considering the advantage that the O / V / W emulsion composition can stably contain oil, an aqueous cosmetic and emulsion It can be preferably used for cosmetics (O / W type, W / O type, W / O / W type, etc.).

  When the O / V / W emulsion composition of the present invention is added to a cosmetic, the content of the O / V / W emulsion composition in the cosmetic can be appropriately selected in consideration of the feeling of use and the like. From the viewpoint of good usability (stickiness, moisturizing feeling), the amount is preferably 5 to 95 parts by mass, more preferably 20 to 80 parts by mass with respect to 100 parts by mass of the cosmetic.

  Hereinafter, the present invention will be described in detail based on examples and comparative examples. The present invention is not limited to these examples.

Examples 1-21 and Comparative Examples 1-6
According to Table 1, Table 2, and Table 3, the O / V / W emulsion composition prepared by the following production method was observed with a microscope, and the structure of the O / V / W emulsion composition was confirmed. Moreover, the usability of the emulsified composition was evaluated based on the following evaluation criteria. The evaluation results are shown in Table 1 and Table 2.
As the hydrogenated soybean phospholipid, Coatsome NC-21 (hydrogenated soybean lecithin; manufactured by NOF Corporation) containing 95% by mass or more of phosphatidylcholine was used.

(Evaluation method for composition observation)
The composition is observed with a differential interference microscope and a polarizing microscope (both ECLIPSE 80i, manufactured by Nikon Corporation), and whether or not an emulsified composition in which the vesicle is coated with oil (specifically, shown in FIG. 1 or 2) can be confirmed. Judgment was carried out.

○: A composition in which the vesicles are coated with oil can be confirmed.
X: The composition which the vesicle coat | covered the oil component cannot be confirmed.

(Evaluation method of usability)
Ten professional evaluation panelists evaluated the feeling of use and moisturizing feeling on a non-sticky and moist feeling basis on a five-point scale, and determined by calculating the average score.

(5-level evaluation)
5 points: Very good.
4 points: Good.
3 points: Normal.
2 points: Somewhat bad.
1 point: Bad.

(Preparation method)
A. Components (1) to (17) are heated to 80 ° C. and uniformly dissolved.
B. Ingredients (18) to (21) are heated to 70 ° C. and uniformly dissolved.
C. A was added to B and stirred, and after cooling to 25 ° C., a composition was obtained.

From observation with a differential interference microscope, as shown in FIG. 1, in the O / V / W emulsified composition of the present invention, a vesicle having a particle size of 3 to 4 μm and a particle size of 5 to 40 μm coated with oil are contained. Vesicle-coated oily particles were formed. From observation with a polarizing microscope, the center of the vesicle is brightly displayed, and it can be seen that the vesicle is formed.
This is because a vesicle is formed from (A) an amphiphile and a part of (B) oil in the vicinity of the interface on the oil / water interface between the oil and the aqueous component, and the surface of the remaining (B) oil is formed by the vesicle. It is presumed that vesicle-coated oily particles are formed by being covered.

  Moreover, from the results of Tables 1 and 2, the O / V / W emulsion composition was excellent in moisturizing feeling and in good usability (no stickiness).

Example 8 and Comparative Example 7
About the comparative example 7 created with the following manufacturing method, the microscope observation was performed similarly to the above, and it confirmed that the vesicle and the oil component were disperse | distributed to the water phase, respectively, and the vesicle was not the composition which coat | covered the oil component. Next, the water evaporation suppression effect of the composition prepared in Example 8 and the composition of Comparative Example 7 was evaluated. The evaluation results are shown in FIG.
As the hydrogenated soybean phospholipid, Coatsome NC-21 (hydrogenated soybean lecithin; manufactured by NOF Corporation) containing 95% by mass or more of phosphatidylcholine was used.

(Evaluation method of moisture transpiration suppression effect)
1. 10 μl of the sample of Example 8 and Comparative Example 7 was applied on a hydrophilic membrane filter (MF-Millipore GSWP02500, manufactured by Nippon Millipore; pore diameter 0.22 μm, filter diameter 25 mm) and dried on a 32 ° C. hot plate for 20 minutes. I let you.
2. 5 mL of pure water is added to a Franz diffusion cell (effective area: 0.95 cm ² ), and each membrane filter on which a dry film of the sample is formed and covered with an uncoated membrane filter, room temperature 32 ° C., humidity 20 %.
After 3.6 hours, the Franz diffusion cell was taken out of the thermostatic bath, and the weight change (moisture transpiration amount) was measured.
4). A value obtained by dividing the weight change amount of each sample by the weight change amount of the sample covered with a membrane filter to which nothing was applied was evaluated as a moisture transpiration suppression rate.

(Preparation method) Comparative Example 7
In the formulation of Example 8, the timing of adding the component (10) was changed. Ingredients (1) and (17) are heated to 80 ° C. and dissolved uniformly.
B. Ingredients (18) to (21) are heated to 70 ° C. and uniformly dissolved.
C. A was added to B, stirred, and cooled to room temperature.
D. (10) was added to C at room temperature and stirred to obtain a composition.

  As shown in FIG. 3, the O / V / W emulsion composition of the present invention was excellent in moisture transpiration suppression effect. That is, an O / V / W emulsion composition (Example 8) having vesicle-coated oily particles as a dispersed phase is an O / W emulsion composition (Comparative Example 7) in which the vesicle and the oil component are dispersed independently. ), It was found that an excellent effect of suppressing moisture transpiration was obtained.

  Further, after the vesicle-coated oil-in-water emulsion composition of Example 8 was stored at room temperature for half a year, the appearance was visually changed and the structure of the composition was confirmed with a microscope in the same manner as described above. There was no separation, discoloration, odor and the like of the W emulsified composition, and there was no structural change of the vesicle-coated oily particles, and the emulsion was stably held.

Claims (4)

An oil / vesicle / water emulsion composition comprising the following components (A) to (D),
(A) One or two selected from the group consisting of soybean lecithin, egg yolk lecithin, soybean lecithin hydrogenated substance, egg yolk lecithin hydrogenated substance, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol and sphingophospholipid More than a kind of amphiphile,
(B) isononyl isononanoate, propylene glycol dicaprate, isostearyl alcohol, propylene glycol dicaprylate, trimethylolpropane trioctanoate, octyldodecyl lactate, polyglyceryl diisostearate, polyglyceryl triisostearate, isostearyl glyceryl ether, the following general formula (1 ) Propylene glycol monoester represented by
(In the formula, R ¹ represents a linear or branched, saturated or unsaturated hydrocarbon group having 9 to 23 carbon atoms)
One or more selected from the group consisting of: an IOB value of 0.2 to 0.54, and a melting point of 30 ° C. or less,
(C) ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol (average molecular weight less than 1000), propylene glycol, dipropylene glycol, polypropylene glycol (average molecular weight: less than 1000), glycerin, diglycerin, polyglycerin, isoprene glycol, 1 , 2-pentanediol, 1,3-butylene glycol and hexylene glycol, one or more polyhydric alcohols selected from the group consisting of
(D) Aqueous component (excluding (C) polyhydric alcohol),
(D) The surface of the component (B) not contained in the vesicle by the vesicle having an average particle diameter of 1 to 5 μm formed from the component (A) and a part of the component (B), wherein the aqueous component is a continuous phase Vesicle-coated oily particles having an average particle diameter of 10 to 60 μm coated with
(1) After heating the components (A), (B) and (C) above the phase transition temperature and mixing them uniformly,
(2) mixing with component (D) above the phase transition temperature, then
(3) Cool below the phase transition temperature
An oil / vesicle / water emulsion composition obtained by   (A) Amphiphile and (B) The IOB value is 0.20 to 0.54, and the content mass ratio [A / B] of the oil having a melting point of 30 ° C. or less is 1 / 0.01 to 1/200. The oil / vesicle / water emulsion composition according to claim 1. The content of component (A) is 0.001 to 20 mass%, the content of component (B) is 0.05 to 60 mass%, the content of component (C) is 1 to 10 mass%, and component (D) claim 1 or 2 oil / vesicles / water emulsion composition according content is from 20 to 98.9499% by mass. A cosmetic comprising the oil / vesicle / water emulsion composition according to any one of claims 1 to 3 .