JP5992309B2 - Composition for improving oral odor - Google Patents

Description

  The present invention relates to a composition for improving oral body odor, and more particularly to a composition for improving body odor that can improve human body odor by ingestion orally and a method for improving body odor using the same.

  Body odor is composed of various volatile components released from the body, and is known to change in various situations such as diet, stress, aging, and various diseases. In particular, the relationship between eating habits and body odor is widely known, and a typical example is Oiso.

  This body odor includes the odor of ingredients contained in human sweat, the smell of secretions from the skin, or the odor caused by their oxides, foul odor, foot odor, halitosis, manure odor, aging odor, etc. It has been known. Since these odors feel unpleasant for humans, various measures have been taken to eliminate these odors (Patent Documents 1 to 3).

  However, as described above, the body odor is a composite odor composed of various odor components, and it is very difficult to cope with various odors, and it cannot be said that sufficient measures are taken.

  On the other hand, Kampo medicines that improve body odor have also been reported for a long time in medical minds, and as a representative example, body aroma is known. The body fragrance is made of herbal medicine with strong fragrance, and it is said that when ingested, it releases fragrance from the body and can improve body odor.

  In addition, regarding linalool, citronellol and geraniol, which are representative components of the scent of roses, these components themselves are released from the body (Non-patent Document 1) and can improve body odor. That is, it can be said that a substance released from the body by ingestion may have an effect of improving body odor.

  However, compounds or compositions that have been released from the body surface by oral ingestion and have a sufficient effect to exhibit an unpleasant body odor (hereinafter referred to as “masking”) and a harmony effect (hereinafter referred to as “harmonage”) have been used so far. The fact was not known. In addition, the “harmonage” in the present invention is an effect that makes it possible to harmonize the whole odor including body odor even in the presence of various body odors, and to eliminate the discomfort of body odors. Means.

JP 2010-248120 A JP2009-280573 JP-A-11-286423

BUNSEKI KAGAKU Vol55, No10, 787-792 (2006)

  This invention is made | formed in view of the said situation, The subject is providing the composition for oral body odor improvement which can fully mask and / or harmonize body odor by ingesting orally. It is.

  As a result of intensive studies to solve the above problems, the present inventors have found that body odor can be effectively masked and / or harmonized by ingesting a composition containing guaiacol and hexenol. The present invention has been completed.

That is, the present invention
(1) A composition for improving oral odor containing guaiacol and hexenol,
(2) The composition for improving oral odor according to (1), further comprising at least one compound selected from linalool oxide, anethole and phenethyl alcohol,
(3) The composition for improving oral odor according to (1) or (2), which is a food and a medicine,
(4) The composition for improving oral odor according to any one of (1) to (3), wherein the body odor is an aging odor, halitosis or foot odor,
(5) A method for improving body odor characterized by orally ingesting a composition containing guaiacol and hexenol,
(6) A method for improving body odor characterized by orally ingesting a composition containing guaiacol and hexenol and at least one compound selected from linalool oxide, anethole and phenethyl alcohol.

  According to the present invention, it is possible to provide an oral body odor improving composition capable of effectively improving body odor.

  Guaiacol, one of the body odor improving components used in the present invention, is a known compound whose general name is 2-methoxyphenol. This is used as a fragrance for coffee, chocolate, and the like.

  The other component, hexenol, is one of unsaturated alcohols also called green leaf alcohols, is a known compound that has a characteristic odor of blue odor and is used as a raw material for perfumes and the like.

  However, there has been no report about the substances released from the body surface masking or harming unpleasant body odors by ingesting these guaiacol and hexenol.

  In the composition for improving oral odor according to the present invention, the above-mentioned guaiacol and hexenol are used in combination as essential components. The blending amounts of guaiacol and hexenol in this composition are within the safe range of oral intake described in the Food Additives Official Document, and the blending ratio is not particularly limited as long as each component is within the safe range. However, the blending amounts of general guaiacol and hexenol are 0.001 to 10% by mass (hereinafter referred to as “%”), preferably 0.005% to 5%, based on the total composition. More preferably, it is 0.01 to 3%.

  In the present invention, the essential body odor improving component of guaiacol and hexenol can be used in combination with at least one compound selected from linalool oxide, anethole, and phenethyl alcohol, if necessary. Each of these components used in combination is a known compound.

  When the above linalool oxide, anethole, and phenethyl alcohol are used in combination, the blending amount is within the safe range of oral intake described in the Food Additives Official Statement, and the blending ratio is within the safe amount range for each component. If there is no particular limitation. The general blending amount is 0.00005 to 5000 parts by weight, preferably 0.0005 to 500 parts by weight, and more preferably 0.0016 to 150 parts per 100 parts by weight of the total amount of guaiacol and hexenol. Parts by weight.

  The composition for improving oral odor of the present invention comprises the above-mentioned guaiacol and hexenol, or these and a combination component such as linalool oxide in a known oral pharmaceutical ingredient or food material, and is formulated according to a conventional method. To prepare in the form of a pharmaceutical, quasi-drug or food.

  Examples of oral pharmaceutical ingredients or food materials used in the body odor improving composition of the present invention include excipients, pH adjusters, cooling agents, suspending agents, antifoaming agents, thickeners, and dissolution aids. Agents, disintegrating agents, binders, lubricants, antioxidants, coating agents, coloring agents, flavoring agents, surfactants, plasticizers, etc., and these are qualitative and quantitative amounts that do not impair the effects of the invention. It can be used within the scope.

  Among the above components, organic and inorganic edible acids can be used as the pH adjuster. Acids are in their undissociated form or include their respective salts such as citric acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid or mixtures thereof It is an edible organic acid. Also, bicarbonate, potassium hydrogen phosphate or sodium, potassium dihydrogen phosphate or sodium, and the like can be used.

  Examples of the antioxidant include vitamin C, dibutylhydroxytoluene (BHT), propyl gallate, butylhydroxyanisole (BHA), α-tocopherol, citric acid, and the like, and examples of the colorant include tar dye and titanium oxide. , Surfactants include polyglycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, sorbitan monostearate, sorbitan monopalmitate, sorbitan monolaurate, polyoxyethylene polyoxypropylene block copolymer, polysorbates, sodium lauryl sulfate, macro Examples thereof include galls and sucrose fatty acid esters.

  Further, in the food material used in the composition for improving oral odor of the present invention, minerals include sodium ion, potassium ion, calcium, chromium, copper, iron, magnesium, manganese, phosphorus, selenium, silicon, molybdenum or As sweeteners for enhancing the palatability of zinc and the like, high-intensity sweeteners such as stevia, sucralose, acesulfame potassium and aspartame, carbohydrates such as sucrose, sugar alcohols such as sorbitol, erythritol and xylitol, glycerin Examples of vitamins include vitamin A, vitamin B, vitamin C, vitamin D and vitamin E, or various derivatives thereof, taurine and the like.

  Furthermore, you may add various compounds, a fragrance | flavor, etc. to the composition of this invention. Examples of the added compound include 1,8-cineole, rose oxide, carvone, methyl-β-naphthyl ketone, 2-acetylfuran, menthone, cis-jasmon, linalool, α-terpineol, 4-terpineol, limonene, Examples include γ-terpinene, myrcene, p-cymene, terpinolene, β-naphthylethyl ether, eugenol, isoamyl alcohol, cis-3-hexenyl alcohol, and phenylethyl alcohol.

  The preferred form of the composition for improving oral odor of the present invention is a pharmaceutical product or a quasi-drug, and its dosage form is a liquid, tablet, granule, powder, capsule, dry syrup, chewable tablet, transmucosal agent. And oral dosage forms such as enteric preparations.

  For example, if the form of the composition for improving oral odor is a liquid agent, an antioxidant, a coloring agent, a corrigent, a surfactant, a plasticizer, a pH adjuster, etc. are mixed, and a dry syrup agent and a liquid agent are mixed in a conventional manner. Orally. In the case of a solid agent, an excipient, a disintegrant, a binder, a lubricant, an antioxidant, a coating agent, a coloring agent, a flavoring agent, a surfactant, a plasticizer, and the like are mixed. Granules, powders, capsules, tablets and the like can be produced.

  The range of the amount of guaiacol and hexenol consumed per day using the composition for improving body odor of the present invention produced as described above varies depending on the age of the user, the strength of body odor, etc. However, it is usually 1 mg to 10000 mg, preferably 5 mg to 5000 mg, more preferably 10 mg to 3000 mg per day. What is necessary is just to divide the oral body odor improving composition which becomes such an amount into 1 to several times.

  Similarly, the range of the amount of linalool oxide, anethole, and phenethyl alcohol when used in combination also varies depending on the age of the user, the intensity of body odor, etc., but is usually 1 mg to 10,000 mg per day, preferably It is 5 mg to 5000 mg, more preferably 10 mg to 3000 mg. What is necessary is just to divide the oral body odor improving composition which becomes such an amount into 1 to several times.

  By ingesting the above amount from the oral route, the aroma component is released from the body surface, and the body odor can be masked and / or harmonized and deodorized.

  The present invention will be described more specifically with reference to the following examples. However, the present invention is not limited thereto.

Example 1
In vitro transpiration test:
Guaiacol, cis-3-hexenol, linalool oxide, anethole, and phenethyl alcohol were each administered into the duodenum at a dose of 1 mL / kg to SD male rats under pentobarbital anesthesia. A glass vial with a capacity of 10 mL was attached to the site including the bottom of the foot, and the transpiration was collected for 3 hours. At this time, the temperature of the glass vial was kept at about 40 ° C.

  The collected transpiration material in the glass vial was collected with 1 mL of ethanol, filtered through a 0.45 μm filter, and then analyzed using a GC-MS system (TraceGC-PoralisQ) manufactured by Thermo Fisher Scientific. did.

  DB-5 ms (30 m × 0.25 mm × 0.25 μm) was used for the analytical column, helium gas was used for the carrier gas, and the flow rate was 1.2 mL / min. The oven temperature was held at 50 ° C. for 1 minute, then increased to 180 ° C. at a rate of 5 minutes per minute, then increased to 300 ° C. at a rate of 20 ° C. per minute and held for 5 minutes. The inlet temperature was 250 ° C., the ion source temperature was 230 ° C., and the transfer line temperature was 280 ° C.

  As a result of analyzing the mass spectrum of the peak of the obtained chromatogram, it was confirmed that the collected components were contained in the collected transpiration product.

  As a result, it has been clarified that after ingestion of guaiacol, cis-3-hexenol, linalool oxide, anethole, and phenethyl alcohol, the components themselves are released from the body surface.

Example 2
Deodorization test 1:
(1) Compositions 1-4 and comparative compositions 1-2 containing guaiacol, cis-3-hexenol, linalool oxide, anethole and phenethyl alcohol in the amounts shown in Table 1 were prepared.

(2) The compositions 1-4 prepared in the above (1) and the comparative compositions 1-2 were added to a vial having a capacity of about 150 cm ³ , and 0.1 mL of an aging odor model was further added. Next, the masking and harmony effects on the aging odor model were verified by the following sensory evaluation test. The results are shown in Table 2.

(Aging odor model)
Component Mass (%)
Dibutylhydroxytoluene 1
Heptanoic acid 10
Octanoic acid 10
Nonenal 0.2
Octenal 0.03
Triethyl citrate 78.77

(Sensory evaluation of masking)
The masking effect was evaluated with the following five-level score.
1: Very strong aging odor 2: Slightly aging odor 3: Aging odor 4: Slightly aging odor 5: No aging odor

(Sensory evaluation of harmony)
The harmony effect was evaluated using the following five-point score.
2: Harmonized 1: Slightly harmonized 0: Neither -1: Slightly harmonized -2: Not harmonized

<Effect on aging odor>

  As a result, it became clear that the compositions 1 to 4 showed superior masking effect and harmony effect compared to the comparative compositions 1 and 2 for the aging odor model.

Example 3
Add compositions 1 to 4 and comparative compositions 1 to 2 shown in Table 1 of Example 2 into a vial having a capacity of about 10 mL, and further add 1 mL of air in the vial containing the bad breath model or foot odor model to a syringe. Added. Next, masking and harmony effects on bad breath and foot odor were verified by the following sensory evaluation test. The results are shown in Tables 3 and 4.

(Bad breath model)
To a vial of about 10 mL capacity, 100 μL of 2-mercaptoethanol was added.
(Foot odor model)
To a vial with a volume of about 10 mL was added 100 μL of iso-amino acid.

(Sensory evaluation of masking)
The masking effect was evaluated with the following five-level score.
1: Feels bad breath or foot odor very strongly 2: Feels bad breath or foot odor 3: Feels bad breath or foot odor 4: Feels weak or bad foot odor 5: Does not feel bad breath or foot odor

(Sensory evaluation of harmony)
The harmony effect was evaluated using the following five-point score.
2: Harmonized 1: Slightly harmonized 0: Neither -1: Slightly harmonized -2: Not harmonized

<Effects on bad breath model>

<Effects on foot odor model>

  As a result, it became clear that the compositions 1 to 4 showed superior masking effect and harmony effect compared to the comparative compositions 1 and 2 for the bad breath and foot odor models.

Treatment example 1
Preparation of oral solution:
The components listed in Table 5 below were dissolved in 15% of the total amount of water and stirred thoroughly. Next, the pH was adjusted to 3.0 with citric acid and sodium citrate, and a beverage stock solution having a concentration of 25% of the total amount was prepared. Finally, purified water was added to the beverage stock solution to make a total amount, and the solution was filled in a 100 ml glass bottle to obtain an internal solution. This internal liquid solution was able to improve body odor and had good dosing properties.

  The composition of the present invention can be masked and / or harmonized by ingesting it, effectively improving body odor and effectively reducing unpleasant body odor.

Claims (3)

A composition containing guaiacol and hexenol, which is taken orally and used to improve aging odor or foot odor .   The composition according to claim 1, further comprising at least one compound selected from linalool oxide, anethole and phenethyl alcohol. The composition according to claim 1 or 2, which is a food or a medicine.