JP5922156B2 - 分析フィルタリングおよび分離用ｄｃイオンガイド - Google Patents
分析フィルタリングおよび分離用ｄｃイオンガイド Download PDFInfo
- Publication number
- JP5922156B2 JP5922156B2 JP2013557171A JP2013557171A JP5922156B2 JP 5922156 B2 JP5922156 B2 JP 5922156B2 JP 2013557171 A JP2013557171 A JP 2013557171A JP 2013557171 A JP2013557171 A JP 2013557171A JP 5922156 B2 JP5922156 B2 JP 5922156B2
- Authority
- JP
- Japan
- Prior art keywords
- ion guide
- ions
- ion
- mass
- charge ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000926 separation method Methods 0.000 title claims description 15
- 238000001914 filtration Methods 0.000 title description 7
- 150000002500 ions Chemical class 0.000 claims description 245
- 238000006243 chemical reaction Methods 0.000 claims description 15
- 230000005284 excitation Effects 0.000 claims description 13
- 238000010884 ion-beam technique Methods 0.000 claims description 11
- 230000001133 acceleration Effects 0.000 claims description 8
- 230000005684 electric field Effects 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 230000001052 transient effect Effects 0.000 claims description 5
- 238000004458 analytical method Methods 0.000 claims description 4
- 230000007423 decrease Effects 0.000 claims description 4
- 238000011144 upstream manufacturing Methods 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 230000001939 inductive effect Effects 0.000 claims description 3
- 230000035945 sensitivity Effects 0.000 claims description 3
- 238000013467 fragmentation Methods 0.000 description 23
- 238000006062 fragmentation reaction Methods 0.000 description 23
- 238000010494 dissociation reaction Methods 0.000 description 8
- 230000005593 dissociations Effects 0.000 description 8
- 238000007792 addition Methods 0.000 description 6
- 238000005040 ion trap Methods 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 5
- 230000001419 dependent effect Effects 0.000 description 4
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 3
- 238000001360 collision-induced dissociation Methods 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 238000000688 desorption electrospray ionisation Methods 0.000 description 2
- 238000001211 electron capture detection Methods 0.000 description 2
- 238000001077 electron transfer detection Methods 0.000 description 2
- 238000010265 fast atom bombardment Methods 0.000 description 2
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 238000009616 inductively coupled plasma Methods 0.000 description 2
- 238000001698 laser desorption ionisation Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 1
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 description 1
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 1
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 1
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 description 1
- 238000000451 chemical ionisation Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004070 electrodeposition Methods 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 230000006862 enzymatic digestion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000165 glow discharge ionisation Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- -1 nickel-63 ion Chemical class 0.000 description 1
- 238000004150 penning trap Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K1/00—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/426—Methods for controlling ions
- H01J49/427—Ejection and selection methods
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/28—Static spectrometers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/422—Two-dimensional RF ion traps
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1103858.5A GB201103858D0 (en) | 2011-03-07 | 2011-03-07 | DC ion guide for analytical filtering/separation |
| GB1103858.5 | 2011-03-07 | ||
| US201161452776P | 2011-03-15 | 2011-03-15 | |
| US61/452,776 | 2011-03-15 | ||
| PCT/GB2012/050502 WO2012120297A1 (en) | 2011-03-07 | 2012-03-07 | Dc ion guide for analytical filtering/separation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014511003A JP2014511003A (ja) | 2014-05-01 |
| JP2014511003A5 JP2014511003A5 (cg-RX-API-DMAC7.html) | 2016-04-07 |
| JP5922156B2 true JP5922156B2 (ja) | 2016-05-24 |
Family
ID=43923329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557171A Expired - Fee Related JP5922156B2 (ja) | 2011-03-07 | 2012-03-07 | 分析フィルタリングおよび分離用ｄｃイオンガイド |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9111654B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2684208B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5922156B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2829011A1 (cg-RX-API-DMAC7.html) |
| GB (2) | GB201103858D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012120297A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201114734D0 (en) | 2011-08-25 | 2011-10-12 | Micromass Ltd | Mass spectrometer |
| GB201114735D0 (en) | 2011-08-25 | 2011-10-12 | Micromass Ltd | Mass spectrometer |
| US8809769B2 (en) * | 2012-11-29 | 2014-08-19 | Bruker Daltonics, Inc. | Apparatus and method for cross-flow ion mobility spectrometry |
| JP6495192B2 (ja) * | 2013-03-13 | 2019-04-03 | マイクロマス ユーケー リミテッド | トロイダルトラップ構造のパルスイオン源 |
| US10497551B2 (en) | 2013-12-24 | 2019-12-03 | Micromass Uk Limited | Storage ring for fast processes |
| WO2015155551A1 (en) | 2014-04-11 | 2015-10-15 | Micromass Uk Limited | Ion entry/exit device |
| US9330894B1 (en) * | 2015-02-03 | 2016-05-03 | Thermo Finnigan Llc | Ion transfer method and device |
| CN106373854B (zh) | 2015-07-23 | 2018-12-21 | 株式会社岛津制作所 | 一种离子导引装置 |
| GB2558221B (en) * | 2016-12-22 | 2022-07-20 | Micromass Ltd | Ion mobility separation exit transmission control |
| US10236168B1 (en) | 2017-11-21 | 2019-03-19 | Thermo Finnigan Llc | Ion transfer method and device |
| EP3753043B1 (en) * | 2018-02-16 | 2022-03-30 | Micromass UK Limited | Quadrupole devices |
| AU2019269449A1 (en) * | 2018-05-14 | 2020-12-10 | MOBILion Systems, Inc. | Coupling of ion mobility spectrometer with mass spectrometer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5783824A (en) | 1995-04-03 | 1998-07-21 | Hitachi, Ltd. | Ion trapping mass spectrometry apparatus |
| US6177668B1 (en) * | 1996-06-06 | 2001-01-23 | Mds Inc. | Axial ejection in a multipole mass spectrometer |
| GB2390935A (en) | 2002-07-16 | 2004-01-21 | Anatoli Nicolai Verentchikov | Time-nested mass analysis using a TOF-TOF tandem mass spectrometer |
| US6838666B2 (en) * | 2003-01-10 | 2005-01-04 | Purdue Research Foundation | Rectilinear ion trap and mass analyzer system and method |
| DE112004000453B4 (de) * | 2003-03-19 | 2021-08-12 | Thermo Finnigan Llc | Erlangen von Tandem-Massenspektrometriedaten für Mehrfachstammionen in einer Ionenpopulation |
| EP1704578B1 (en) | 2004-01-09 | 2011-04-27 | Micromass UK Limited | Ion extraction devices and methods of selectively extracting ions |
| GB0514964D0 (en) | 2005-07-21 | 2005-08-24 | Ms Horizons Ltd | Mass spectrometer devices & methods of performing mass spectrometry |
| GB0416288D0 (en) | 2004-07-21 | 2004-08-25 | Micromass Ltd | Mass spectrometer |
| GB0524042D0 (en) * | 2005-11-25 | 2006-01-04 | Micromass Ltd | Mass spectrometer |
| GB2454508B (en) | 2007-11-09 | 2010-04-28 | Microsaic Systems Ltd | Electrode structures |
| GB2476964A (en) * | 2010-01-15 | 2011-07-20 | Anatoly Verenchikov | Electrostatic trap mass spectrometer |
| GB201114735D0 (en) * | 2011-08-25 | 2011-10-12 | Micromass Ltd | Mass spectrometer |
-
2011
- 2011-03-07 GB GBGB1103858.5A patent/GB201103858D0/en not_active Ceased
-
2012
- 2012-03-07 WO PCT/GB2012/050502 patent/WO2012120297A1/en not_active Ceased
- 2012-03-07 EP EP12715703.0A patent/EP2684208B1/en active Active
- 2012-03-07 JP JP2013557171A patent/JP5922156B2/ja not_active Expired - Fee Related
- 2012-03-07 GB GB1203983.0A patent/GB2491678B/en active Active
- 2012-03-07 US US14/003,487 patent/US9111654B2/en active Active
- 2012-03-07 CA CA2829011A patent/CA2829011A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2684208B1 (en) | 2018-07-18 |
| GB201203983D0 (en) | 2012-04-18 |
| GB2491678A (en) | 2012-12-12 |
| GB201103858D0 (en) | 2011-04-20 |
| US20140048696A1 (en) | 2014-02-20 |
| WO2012120297A1 (en) | 2012-09-13 |
| JP2014511003A (ja) | 2014-05-01 |
| EP2684208A1 (en) | 2014-01-15 |
| US9111654B2 (en) | 2015-08-18 |
| GB2491678B (en) | 2015-10-14 |
| CA2829011A1 (en) | 2012-09-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5922156B2 (ja) | 分析フィルタリングおよび分離用ｄｃイオンガイド | |
| JP6059158B2 (ja) | 直交サンプリングを備えたイオンガイド | |
| JP6027987B2 (ja) | 質量電荷比に依存しない閉じ込めによる湾曲型イオンガイド | |
| US8946626B2 (en) | Ion trap with spatially extended ion trapping region | |
| JP5623428B2 (ja) | Ｍｓ／ｍｓ／ｍｓを行なう質量分析計 | |
| GB2485063A (en) | Differential ion mobility separation in a RF linear ion trap | |
| JP6214533B2 (ja) | 空間的に拡張されたイオントラップ領域を有するイオントラップ | |
| JP2009514179A5 (cg-RX-API-DMAC7.html) | ||
| JP5684957B2 (ja) | 環状イオンガイド | |
| CA2829844A1 (en) | Pre-scan for mass to charge ratio range | |
| US9548194B2 (en) | Toroidal trapping geometry pulsed ion source | |
| CA2815435A1 (en) | Asymmetric field ion mobility in a linear geometry ion trap |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150305 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20151117 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20160217 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160315 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160413 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5922156 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |