JP5902673B2 - 眼疾患の処置のためのキノンの製剤 - Google Patents

眼疾患の処置のためのキノンの製剤 Download PDF

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Publication number
JP5902673B2
JP5902673B2 JP2013508167A JP2013508167A JP5902673B2 JP 5902673 B2 JP5902673 B2 JP 5902673B2 JP 2013508167 A JP2013508167 A JP 2013508167A JP 2013508167 A JP2013508167 A JP 2013508167A JP 5902673 B2 JP5902673 B2 JP 5902673B2
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Prior art keywords
formulation
disease
formula
quinone
eye
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Expired - Fee Related
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JP2013508167A
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Japanese (ja)
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JP2013525443A (ja
JP2013525443A5 (cg-RX-API-DMAC7.html
Inventor
ガイ エム． ミラー，
ガイ エム． ミラー，
Original Assignee
エジソン ファーマシューティカルズ， インコーポレイテッド
エジソン ファーマシューティカルズ， インコーポレイテッド
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Publication of JP2013525443A publication Critical patent/JP2013525443A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013508167A 2010-04-27 2011-04-26 眼疾患の処置のためのキノンの製剤 Expired - Fee Related JP5902673B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32854610P 2010-04-27 2010-04-27
US61/328,546 2010-04-27
US39369310P 2010-10-15 2010-10-15
US61/393,693 2010-10-15
PCT/US2011/033983 WO2011137126A1 (en) 2010-04-27 2011-04-26 Formulations of quinones for the treatment of ophthalmic diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016046881A Division JP6266674B2 (ja) 2010-04-27 2016-03-10 眼疾患の処置のためのキノンの製剤

Publications (3)

Publication Number Publication Date
JP2013525443A JP2013525443A (ja) 2013-06-20
JP2013525443A5 JP2013525443A5 (cg-RX-API-DMAC7.html) 2014-06-19
JP5902673B2 true JP5902673B2 (ja) 2016-04-13

Family

ID=44861894

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013508167A Expired - Fee Related JP5902673B2 (ja) 2010-04-27 2011-04-26 眼疾患の処置のためのキノンの製剤
JP2016046881A Expired - Fee Related JP6266674B2 (ja) 2010-04-27 2016-03-10 眼疾患の処置のためのキノンの製剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016046881A Expired - Fee Related JP6266674B2 (ja) 2010-04-27 2016-03-10 眼疾患の処置のためのキノンの製剤

Country Status (13)

Country Link
US (2) US20130109759A1 (cg-RX-API-DMAC7.html)
EP (1) EP2563352A4 (cg-RX-API-DMAC7.html)
JP (2) JP5902673B2 (cg-RX-API-DMAC7.html)
CN (2) CN105147651A (cg-RX-API-DMAC7.html)
AU (1) AU2011245384C1 (cg-RX-API-DMAC7.html)
BR (1) BR112012027543A8 (cg-RX-API-DMAC7.html)
CA (1) CA2797581A1 (cg-RX-API-DMAC7.html)
EA (1) EA201201465A1 (cg-RX-API-DMAC7.html)
MX (1) MX337594B (cg-RX-API-DMAC7.html)
MY (1) MY183449A (cg-RX-API-DMAC7.html)
SG (2) SG10201801321XA (cg-RX-API-DMAC7.html)
WO (1) WO2011137126A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201208535B (cg-RX-API-DMAC7.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005033093A1 (en) 2003-09-19 2005-04-14 Galileo Pharmaceuticals, Inc. 7,8-bicycloalkyl-chroman derivatives
DK2471530T3 (en) 2005-06-01 2017-04-10 Edison Pharmaceuticals Inc REDOXACTIVE THERAPEUTIC AGENTS FOR THE TREATMENT OF MITOCONDARY DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY BIOMARKERS
EP1986636B1 (en) 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases
HUE028502T2 (en) 2007-11-06 2016-12-28 Edison Pharmaceuticals Inc 4- (P-Quinonyl) -2-hydroxybutanamide derivatives for the treatment of mitochondrial diseases
EP2237664A4 (en) * 2008-01-08 2013-05-22 Edison Pharmaceuticals Inc (HET) ARYL-p-CHINONE DERIVATIVES FOR THE TREATMENT OF OCHONDRIAL DISEASES
US8716527B2 (en) 2008-03-05 2014-05-06 Edison Pharmaceuticals, Inc. 2-substituted-p-quinone derivatives for treatment of oxidative stress diseases
US8716486B2 (en) * 2008-06-25 2014-05-06 Edison Pharmaceuticals, Inc. 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases
LT3827815T (lt) 2008-09-10 2023-10-10 Ptc Therapeutics, Inc. Psichologinių raidos sutrikimų gydymas oksidacijos redukcijos atžvilgiu aktyviais vaistais
US10039722B2 (en) 2008-10-14 2018-08-07 Bioelectron Technology Corporation Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells
ES2553557T3 (es) 2008-10-28 2015-12-10 Edison Pharmaceuticals, Inc. Proceso para la producción de alfa-tocotrienol y derivados
HUE037574T2 (hu) 2009-04-28 2018-09-28 Bioelectron Tech Corp Leber-féle örökletes optikus neuropátia és domináns optikus atrofia kezelése tokotrienol kinonokkal
US20110207828A1 (en) * 2009-08-26 2011-08-25 Miller Guy M Methods for the prevention and treatment of cerebral ischemia
JP2013523816A (ja) * 2010-04-06 2013-06-17 エジソン ファーマシューティカルズ， インコーポレイテッド 毛細血管拡張性運動失調症の治療
MY183449A (en) * 2010-04-27 2021-02-18 Bioelectron Tech Corp Formulations of quinones for the treatment of ophthalmic diseases
WO2012174286A1 (en) 2011-06-14 2012-12-20 Edison Pharmaceuticals, Inc. Catechol derivatives for treatment of oxidative stress diseases
WO2013013078A1 (en) 2011-07-19 2013-01-24 Edison Pharmeceuticals, Inc. Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
US9629815B2 (en) 2012-09-07 2017-04-25 Bioelectron Technology Corporation Benzoquinone derivatives for treating oxidative stress disorders
US9670170B2 (en) 2013-03-15 2017-06-06 Bioelectron Technology Corporation Resorufin derivatives for treatment of oxidative stress disorders
CA2906145A1 (en) 2013-03-15 2014-09-18 Edison Pharmaceuticals, Inc. Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders
US9296712B2 (en) 2013-03-15 2016-03-29 Edison Pharmaceuticals, Inc. Resorufin derivatives for treatment of oxidative stress disorders
US9868711B2 (en) 2013-03-15 2018-01-16 Bioelectron Technology Corporation Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
NZ733528A (en) 2014-12-16 2021-07-30 Ptc Therapeutics Inc Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide
JP7117241B2 (ja) 2015-12-16 2022-08-12 ピーティーシー セラピューティクス， インコーポレイテッド 混合されたトコール組成物からアルファ－トコトリエノールを富化するための改良された方法
CA3008849A1 (en) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
JP2018083799A (ja) 2016-11-15 2018-05-31 バイオエレクトロン テクノロジー コーポレイション ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩
US11260048B2 (en) 2017-10-03 2022-03-01 The Schepens Eye Research Institute, Inc. Compounds and compositions for inhibiting retinal pigment epithelium degeneration and methods using the same
HUE066196T2 (hu) 2018-10-17 2024-07-28 Ptc Therapeutics Inc 2,3,5-trimetil-6-nonilciklohexa-2,5-dién-1,4-dion alfa-szinukleinopátiák, tauopátiák és egyéb rendellenességek szuppresszálására és kezelésére
JP7705106B2 (ja) * 2019-05-28 2025-07-09 ナノ－ネオ リミテッド 網膜症を治療するための組成物及び方法
CA3225266A1 (en) 2021-07-08 2023-01-12 Swathi PINNAMANENI Pharmaceutical compositions comprising 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione
WO2025231245A1 (en) * 2024-05-02 2025-11-06 Stealth Biotherapeutics Inc. Use of substituted 1,4 benzoquinones to treat alpha-synucleinopathies

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2471530T3 (en) * 2005-06-01 2017-04-10 Edison Pharmaceuticals Inc REDOXACTIVE THERAPEUTIC AGENTS FOR THE TREATMENT OF MITOCONDARY DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY BIOMARKERS
EP1924292A2 (en) * 2005-09-16 2008-05-28 Allergan, Inc. Compositions and methods for the intraocular transport of therapeutic agents
EP1986636B1 (en) * 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases
LT3827815T (lt) * 2008-09-10 2023-10-10 Ptc Therapeutics, Inc. Psichologinių raidos sutrikimų gydymas oksidacijos redukcijos atžvilgiu aktyviais vaistais
US20110207828A1 (en) * 2009-08-26 2011-08-25 Miller Guy M Methods for the prevention and treatment of cerebral ischemia
JP2013523816A (ja) * 2010-04-06 2013-06-17 エジソン ファーマシューティカルズ， インコーポレイテッド 毛細血管拡張性運動失調症の治療
MY183449A (en) * 2010-04-27 2021-02-18 Bioelectron Tech Corp Formulations of quinones for the treatment of ophthalmic diseases

Also Published As

Publication number Publication date
AU2011245384A1 (en) 2012-12-06
SG185046A1 (en) 2012-12-28
JP2016106144A (ja) 2016-06-16
US20170354618A1 (en) 2017-12-14
US20130109759A1 (en) 2013-05-02
JP2013525443A (ja) 2013-06-20
EP2563352A4 (en) 2013-11-13
SG10201801321XA (en) 2018-04-27
WO2011137126A1 (en) 2011-11-03
JP6266674B2 (ja) 2018-01-24
MX2012012518A (es) 2012-12-17
EA201201465A1 (ru) 2013-04-30
CN105147651A (zh) 2015-12-16
EP2563352A1 (en) 2013-03-06
AU2011245384B2 (en) 2016-02-18
AU2011245384C1 (en) 2016-09-01
CA2797581A1 (en) 2011-11-03
CN102985083A (zh) 2013-03-20
MY183449A (en) 2021-02-18
BR112012027543A2 (pt) 2019-05-28
ZA201208535B (en) 2016-06-29
MX337594B (es) 2016-03-11
BR112012027543A8 (pt) 2019-12-03

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