JP5899965B2 - Method for producing external preparation for skin - Google Patents

Description

  The present application discloses a skin external preparation tool, a skin external preparation holder, and a method for producing a skin external preparation tool.

  In recent years, skin care using a cosmetic sheet such as a mask or a pack (facial mask) has been performed. A non-woven fabric or a woven fabric impregnated with collagen, gelatin, hyaluronic acid, chitin, chitosan, amino acids or a mixture thereof as skin care components is used for the cosmetic sheet (see, for example, Patent Document 1). These non-woven fabric or woven fabric cosmetic sheets are impregnated with skin lotion or the like, and are applied to the skin surface.

  Moreover, only a topical skin component such as a synthetic polypeptide having a collagen-like structure is formed into a sponge-like, gel-like, or film-like sheet by physical treatment such as heating, cooling, freeze-drying, and drying under reduced pressure. The thing used as a skin external preparation sheet | seat is also proposed (for example, refer patent document 2). In that case, a large sheet is first manufactured, and a sheet cut or stamped according to the dimensional shape of the application portion is attached to the skin surface.

  In order to reduce the restriction of the user's behavior during the period when the skin external preparation sheet is applied, and to facilitate the handling of the skin external preparation sheet, an outer edge is provided around the skin external preparation component sheet. There has been proposed one in which a skin external preparation component sheet is pressure-bonded and laminated on one side of a base fabric made of a water-repellent nonwoven fabric or woven fabric having a shape and area that can be formed (for example, Patent Document 3).

JP 2005-263759 A JP 2007-137875 A JP 2010-163386 A

  Since the skin external preparation component remains in the base fabric even after use, the sheet obtained by impregnating the base fabric made of nonwoven fabric or woven fabric with the skin external preparation component inevitably discards the skin external preparation component. In addition, when a skin external preparation component such as collagen is formed into a sheet or the like by freeze-drying, cracks etc. are likely to occur. Or the film needs to be hardened. When thickening the membrane, it is necessary to increase the amount of the aqueous solution of the external preparation for skin and freeze-dry it before shaping. To harden the membrane, freeze the solution by increasing the concentration of the aqueous solution for external preparation for skin. Need to be molded. However, if the amount of the aqueous solution of the external preparation for skin is increased or the film is formed at a high concentration, the amount of the external preparation for skin constituting the membrane increases, so that the external preparation for skin is solid on the skin surface during use. It remains as a product.

  Therefore, the present application provides a skin external preparation that can be easily handled even if the amount of the skin external preparation component formed by lyophilization is reduced so that the skin external preparation component does not remain on the skin surface during use. It is an object of the present invention to provide a tool, a skin external preparation holder, and a method for producing a skin external preparation tool.

  In order to solve the above-mentioned problems, the present invention provides freeze-drying of a skin external preparation at the other end of a holder that is open at both ends and gripped at one end, and an aqueous solution of the skin external preparation component so as to close the opening at the other end. Formed.

  Specifically, the present invention is a holder having both ends open, the holder having an end capable of gripping the holder at one end, and an aqueous solution of a skin external preparation component formed by lyophilization, A skin external preparation device comprising: a skin external preparation that is fixed so as to close an opening at the other end of the holder.

  If the holder is open at both ends, when the skin external preparation is lyophilized to form a skin external preparation, the removal of moisture in the aqueous solution is not hindered and the opening of the holder is blocked. An external preparation for skin can be fixed to the skin. In addition, by grasping the end opposite to the side where the external preparation for skin is fixed, the user can grasp the external preparation and apply the external preparation to the skin without directly touching the external preparation. Can do.

  With this skin external preparation tool, since the user can grasp the skin external preparation tool without directly touching the skin external preparation, almost no force is applied to the skin external preparation. In use, almost no force is applied to the external preparation for skin, so that even a sheet formed by reducing the amount of external preparation for skin formed by freeze-drying does not crack. Therefore, even if the amount of the external preparation for skin is reduced, the external preparation for skin can be easily handled.

  The holder may be a cylindrical holder whose cross section is circular or deformed and open at both ends. Here, the deformed shape includes an elliptical shape, a crescent shape, a gourd shape, and the like. If the holder has a circular cross section, any part of the end opposite to the side to which the external preparation for skin is fixed can be gripped. If the cross section is oval, the narrowest part of the end opposite to the side to which the skin external preparation is fixed can be gripped. If the cross section is a crescent, the skin external preparation It is possible to grip the widest portion of the end on the side opposite to the side where the is fixed. Further, if the cross-section is gourd, the constricted portion of the end opposite to the side on which the skin external preparation is fixed can be gripped, and the area of the skin external preparation to be carried can be reduced. It can be secured sufficiently.

  The external preparation for skin may have at least one of collagen, polypeptide, hyaluronic acid, pullulan, and elastin. When the external preparation for skin has such a component, the wound covering effect and the cosmetic effect of the skin at the site to which the external preparation for skin is applied are promoted.

  The external preparation for skin may be a cosmetic. If the said external preparation for skin is used as cosmetics, the component synthesize | combined by a fibroblast will be supplemented, and the cosmetic effect of the site | part which applied the external preparation for skin will be accelerated | stimulated.

  Moreover, the holding tool may include a carrying part that carries the external preparation for skin and a gripping part that protrudes from the carrying part. If the gripping part for gripping the holding tool protrudes from the carrying part, the holding tool can be easily gripped. In addition, if the gripping part is formed so as to protrude from the carrying part that carries the external preparation for skin, for example, by taking the gripping part to be thinner than the carrying part, it can be removed from the site where the holder is stored Becomes easier.

  Moreover, the opening of the other end of the holder may be subjected to uneven processing for fixing the skin external preparation. If the opening at the other end of the holder has been processed with irregularities, the external preparation for skin formed by freeze-drying the aqueous solution solidifies in a state of engaging with the irregularities, so that the external preparation for skin is unlikely to come off from the holder. .

  Moreover, this invention can also be grasped | ascertained as a holder of an external preparation for skin. That is, an opening at the other end of the holding tool that is open at both ends, has an end that can hold the holding tool at one end, and is formed by freeze-drying an aqueous solution of a skin external preparation component. The external preparation for skin may be fixed and held so as to close it.

  The present invention can also be understood from a method aspect. For example, the present invention is a holder that is open at both upper and lower ends, and an aqueous solution of a skin external preparation component is injected into a holder having an upper end that can hold the holder, and the lower end of the holder It may be a method for producing an external preparation for skin, wherein the aqueous solution soaking the lower end of the holder is freeze-dried. It is possible to efficiently produce the above-described skin external preparation device with relatively few man-hours by injecting an aqueous solution of the skin external preparation component into the holder so as to immerse the lower end of the holder open at both ends, and freeze-drying it. it can.

  Further, the holder is stored in a storage unit that stores the external preparation for skin, the aqueous solution is injected into the holder stored in the storage unit, and a lower end of the holder is immersed in the aqueous solution, and the holding is performed. The aqueous solution soaking the lower end of the tool may be freeze-dried. If the above-mentioned skin external preparation tool is produced using the storage part for housing the skin external preparation tool, it is not necessary to transfer the skin external preparation tool to another container after freeze-drying, so that it can be produced more efficiently.

  Further, the present invention is, for example, a method for manufacturing a skin external preparation device, which is a holder in which an aqueous solution of a skin external preparation component is injected into a storage portion for storing a skin external preparation device, and upper and lower ends are opened. A holder having an upper end at which the holder can be gripped is stored in the storage unit, the lower end of the holder is immersed in the aqueous solution, and the aqueous solution in which the lower end of the holder is immersed is freeze-dried. It may be allowed. The skin external preparation device described above can be efficiently produced with a relatively small number of man-hours by injecting it into the holder into which the aqueous solution of the skin external preparation component is injected and freeze-drying it.

  Moreover, the uneven | corrugated process for making the said skin external preparation adhere may be given to the lower end of the said holder. If the holder has an uneven surface at the lower end, the skin external preparation formed by freeze-drying will be related to the unevenness when it is freeze-dried in a container filled with an aqueous solution of the external preparation for skin. Since it solidifies in the combined state, it is difficult for the external preparation for skin to come off from the holder.

  The holder may be formed of a hydrophilic material, and the storage portion may be formed of a hydrophobic material. When the holder is formed of a hydrophilic material and the storage part is formed of a hydrophobic material, when the holder is inserted into the storage part into which the aqueous solution has been poured, the aqueous solution that accumulates at the bottom of the storage part is retained. To gather. If freeze-drying is performed in this state, the external preparation for skin can be fixed to the holder without remaining in the storage section.

  ADVANTAGE OF THE INVENTION According to this invention, even if it reduces the quantity of the skin external preparation component formed by freeze-drying so that a skin external preparation component may not remain on the skin surface at the time of use, it becomes possible to handle a skin external preparation easily. .

It is an external view of a skin external preparation tool. It is a structural diagram of an external preparation for skin. It is the figure which showed an example of the manufacturing process of the external preparation for skin. It is the figure which showed the 1st example of the tray. It is the figure which showed a mode that the skin external preparation tool was taken out. It is the figure which showed the 2nd example of the tray. It is the figure which showed the 3rd example of the tray. It is a modification of a skin external preparation tool. It is the figure which showed the 4th example of the tray. It is the figure which showed the 5th example of the tray. It is the figure which showed the modification of the cross section of a holder. It is an external view of the skin external preparation tool which concerns on a modification. It is structural drawing of the skin external preparation tool which concerns on a modification. It is the figure which showed an example of the container which stores a skin external preparation tool. It is sectional drawing of the container which accommodated the skin external preparation tool. It is a perspective view of the holder used in the manufacturing process concerning a modification. It is structural drawing of the holder used in the manufacturing process which concerns on a modification. It is the figure which showed an example of the manufacturing process of the skin external preparation tool using the holder which concerns on a modification. It is the 1st figure which showed the modification of the holder. It is the 2nd figure which showed the modification of the holder. It is the 3rd figure which showed the modification of the holder.

  Embodiments of the above invention will be described below. The following embodiments are exemplifications, and do not limit the technical scope of the invention disclosed in the present application.

  The external appearance of the external preparation for skin according to the embodiment is shown in FIG. As shown in FIG. 1, the skin external preparation device 1 includes a cylindrical holder 2 and a skin external preparation 3 carried inside the holder 2. The holder 2 is a member whose upper and lower ends are open. The holder 2 preferably has an outer diameter and a height that can be picked by a finger. For example, the outer diameter is about 12 mm and the height is about 10 mm. In addition, the holder 2 is preferably made of a material that can be easily picked with a finger and to which the skin external preparation 3 is easy to adhere, but at least the force applied to the outer peripheral side surface 4 when the finger is picked up is deformed. Therefore, it is preferable to have a strength that does not collapse. For this reason, when the outer diameter is about 12 mm, for example, the inner diameter is about 10 to 11 mm. Moreover, about a raw material, a polypropylene, PET, and a silicone resin can be illustrated.

The structure of the external preparation for skin 1 is shown in FIG. As shown in FIG. 2, the skin external preparation device 1 carries a sheet-like skin external preparation 3 so as to close the opening at the lower end of the holder 2. The external preparation for skin 3 is obtained by freeze-drying an aqueous solution of the external preparation for skin. Examples of the external preparation for skin include collagen, synthetic polypeptide, hyaluronic acid, pullulan, and elastin. Collagen may be naturally occurring collagen or collagen produced by gene recombination, but may be synthetic collagen. Examples of synthetic collagen include synthetic peptides having an amino acid sequence represented by the following formula, which form a collagen-like structure. In addition, since it does not cause pathogen infection or transmission of pathogenic factors, it has high safety, has high moisturizing properties and stability, and has the advantage of not causing odor.
(Pro-X-Gly) n

  In the above formula, X represents Pro or Hyp, Pro represents an L-proline residue, Hyp represents an L-hydroxyproline residue, and Gly; a glycine residue, and n is an integer of 1 or more, preferably An integer of 4 or more which starts to take a triple helical structure similar to collagen is preferable. The upper limit of n is not particularly defined, but preferably n <100,000 corresponding to the molecular weight capable of maintaining the state as an aqueous solution. In addition, you may use additives, such as a thickener and an excipient | filler normally used for cosmetics or medical use for manufacture of the said skin external preparation 3 as needed.

  The aqueous solution of the external preparation component for skin when the freeze-drying is performed preferably has a concentration and an amount so that the active ingredient can effectively penetrate into the skin and be held at an appropriate strength by the holder 2. Is, for example, more preferably 0.1 to 1.0% by weight, and particularly preferably about 0.5% by weight. If the concentration of the aqueous solution of the external preparation for skin is low, the hardness of the film is insufficient, and the structural strength of the external preparation for skin 3 is reduced. However, the formed external preparation for skin 3 is maintained in an aqueous solution with an appropriate amount of water. The external preparation 3 for skin adheres to the holder 2 by solidifying by freeze-drying while the tool 2 is immersed. Therefore, even if the skin external preparation 3 has a small absolute amount of the external preparation component and low structural strength, it can be easily handled by picking the holder 2 with a finger as long as it is supported on the holder 2. . In addition, when the concentration of the aqueous solution is increased, the film becomes hard and the skin external preparation 3 having high structural strength can be formed, but in that case, the absolute amount of the external preparation component for skin increases, An active ingredient that does not penetrate into the skin remains as a solid on the surface of the skin. The appropriate concentration and amount of the aqueous solution for making the external preparation 3 for skin to be structurally appropriate depends on the shape and size of the holder 2. Depending on the shape and size of the holder 2 to be used, the concentration and amount of the aqueous solution are appropriately determined while observing the balance between the amount of the active ingredient penetrating the skin and the structural strength necessary for the external preparation 3 for skin.

  The external skin preparation device 1 can be manufactured, for example, by the following process. An example of the manufacturing process of the external skin preparation device 1 is shown in FIG.

  When manufacturing the external preparation 1 for skin, the cylindrical holder 2 is placed on the tray 5 (FIG. 3A). The tray 5 is formed with a concave storage portion 6 for storing the external skin preparation tool 1, and the holder 2 is placed in the storage portion 6. Here, the storage portion 6 is a cylindrical storage portion along the cylindrical holder 2, and includes a wall surface 7 that supports the side portion of the skin external preparation device 1 and a bottom surface that supports the lower portion of the skin external preparation device 1. 8. The bottom surface 8 of the storage portion 6 is circular, and the center portion is one step lower than the edge portion. That is, of the two surfaces constituting the bottom surface 8, the first bottom surface 9 constituting the central portion of the bottom surface 8 constitutes an edge portion of the bottom surface 8 and supports the cylindrical lower end of the holder 2. 2 lower than the bottom surface 10 of 2.

  Next, an aqueous solution of a skin external preparation component is injected inside the holder 2 and the lower part of the holder 2 is immersed in the aqueous solution (FIG. 3B). Then, the aqueous solution is freeze-dried (FIG. 3C). When lyophilizing, the tray 5 is cooled while the holder 2 is immersed in the aqueous solution to freeze the aqueous solution. The temperature at the time of freezing depends on the components in the aqueous solution, but if the freezing is insufficient, there is a possibility that a sheet cannot be formed in the drying step described later, so it is desirable that the temperature be sufficiently low.

  After the aqueous solution that immerses the lower part of the holder 2 is sufficiently frozen, the space in which the tray 5 is disposed is decompressed and evacuated. And a vacuum state is hold | maintained, supplying the quantity of heat required for the sublimation of the water | moisture content in aqueous solution to such an extent that the frozen aqueous solution does not melt | dissolve. Since the upper and lower ends of the holder 2 are open, the water in the aqueous solution soaking the lower part of the holder 2 is sublimated so that it passes through the inside of the holder 2. Thereby, the water | moisture content in aqueous solution sublimes, and eventually, aqueous solution freeze-drys and it leads to completion of the skin external preparation 3 (FIG.3 (D)).

  When using the external preparation 1 for skin, the external preparation 1 for skin is removed from the tray 5 (FIG. 3E). Since the external preparation 3 for skin is fixed to the lower part of the holder 2 by freeze-drying, the external preparation 3 for skin peels from the bottom surface 8 of the storage portion 6 when the holder 2 is picked up with a finger and lifted from the tray 5. When the external preparation 3 for skin is applied onto the skin moistened by applying lotion or the like while the holder 2 is picked with a finger, the external preparation 3 for skin permeates the skin. When the skin external preparation 3 penetrates into the skin, it disappears, and only the holder 2 remains in the skin external preparation tool 1.

For example, as shown in FIG. 4, the tray is provided with two storage units 6, and each storage unit 6
You may make it accommodate the skin external preparation tool 1 in this. In this case, the tray 5 may be provided with two grooves 11 for each of the storage units 6 for picking the skin external preparation device 1 stored in the storage unit 6 with a finger. Since the skin external preparation device 1 stored in the storage portion 6 can be easily picked up by providing the groove 11 at the edge of each storage portion 6, the skin external preparation device 1 is used as shown in FIG. Easy to remove from the storage unit 6. In addition, the groove | channel 11 needs to prevent the aqueous solution inject | poured into the holder | retainer 2 from flowing into the groove | channel 11 from the convenience of the said process of forming the skin external preparation 3 by freeze-drying. Therefore, the lowermost portion of the groove 11 is made higher than the bottom surface of the storage portion 6.

  Further, as shown in FIG. 6, the two storage portions 6 may extend in the longitudinal direction of the tray 5. In this case, the groove 11 </ b> _C between the two storage units 6 can be used when the external skin preparation tool 1 in any of the storage units 6 is picked.

  Further, as shown in FIG. 7, the tray 5 may be provided with a lid 12 that can open and close the storage portion 6. If the storage unit 6 can be opened and closed, only one of the external skin preparation tools 1 stored in each storage unit 6 is taken out for use, and the other external skin preparation tools 1 are placed in the storage unit 6. It can be stored in a sealed state.

  As a representative example of a cosmetic tool according to a modification, the appearance of a gourd-shaped holder is shown in FIG. As shown in FIG. 8, the skin external preparation device 21 according to this modification is in a gourd shape when the holder 22 is viewed from above, and the skin external preparation 23 is carried inside the holder 22. As with the holder 2, the upper and lower ends of the holder 22 are open. The conditions regarding the dimensions and material of the holder 22 are the same as those of the holder 2. Similarly to the cylindrical holder 2, the gourd-shaped holder 22 is lyophilized after the lower part of the holder 22 is immersed in an aqueous solution of the skin external preparation component to form the skin external preparation 23. In the case of the gourd-shaped holding tool 22, the area of the skin external preparation 23 can be increased as compared with the cylindrical holding tool 2. For this reason, the skin external preparation 23 can be applied to a wide part of the skin.

  For example, as shown in FIG. 9, the tray for storing the holders 22 is provided with two gourd-shaped storage portions 26, and grooves 31 for gripping the constricted portions of the holders 22 with fingers. Provided at the edge of the portion 26. If the groove 31 is provided at the edge of each storage portion 26, the skin external preparation device 21 stored in the storage portion 26 can be easily picked, so that the skin external preparation device 21 can be easily taken out from the storage portion 26.

  Further, as shown in FIG. 10, the tray 25 may be provided with a lid 32 that can open and close the storage portion 26. If the storage section 26 can be opened and closed, only one of the external skin preparation tools 21 stored in each storage section 26 is taken out for use, and the other external skin preparation equipment 21 is placed in the storage section 26. It can be stored in a sealed state.

  In addition, in the said embodiment and modification, the skin external preparation was carry | supported by the cylindrical or gourd-shaped holder, However, This invention is not limited to such an aspect. That is, the holding device may have any form as long as it can carry the external preparation for skin, and the form can be selected according to the shape of the skin portion to which the external preparation for skin is applied. For example, as shown in FIG. 11, the cross-section of the holder may be oval, crescent, square, polygonal, trapezoidal, or any other shape. Further, the holder need not completely surround the skin external preparation to be carried, and may have a notch, for example. Further, the holder may be provided with a nail for preventing the skin external preparation from detaching, or may be provided with a concavo-convex process at a site carrying the skin external preparation.

<Manufacture of cosmetic tools>
A holder is stored in the storage unit, and a tray into which 0.5% by weight of a synthetic collagen aqueous solution (JNC Co., Ltd., product name: Pure Cola 0.5% aqueous solution) is injected is freeze-dried (main product name: EYELA FDU). -1100 (manufactured by Tokyo Rika Instrument Co., Ltd.), square dry chamber product name: EYELA DRC-1000 (manufactured by Tokyo Rika Instrument Co., Ltd.), vacuum pump: ULVAC-200 (manufactured by ULVAC Kiko Co., Ltd.)) It cooled and frozen until it became -50 degreeC over 10 hours at normal pressure. Thereafter, the vacuum pump was operated and freeze-dried at −50 ° C. for 10 hours (vacuum degree: 9 to 10 Pa), and then the temperature was returned to 25 ° C. and taken out from the freeze dryer. As a result, it was confirmed that an external preparation for skin having an apparent thickness of about 1 mm was formed.

<Evaluation of usability>
Usability when the above-mentioned external preparation for skin was used as a cosmetic was evaluated. That is, a lotion was applied to the skin under the eyes, and a cosmetic that was an external preparation for skin of the external preparation for skin prepared by the above method was applied. When the cosmetic was applied, the cosmetic was dissolved by the lotion applied to the skin part, and the active ingredient of the cosmetic quickly penetrated into the skin and disappeared. When there is no holder, the cosmetic material dissolves on the surface of the finger, or the cosmetic material is damaged by the force of the finger when picking up the cosmetic material, and it is difficult to sufficiently apply the cosmetic material to a desired site. However, as in the present application, by using the holder, the external preparation for skin can be sufficiently applied to a desired site, and the active ingredient can penetrate into the skin. In addition, if the said skin external preparation tool uses a wound therapeutic agent as a skin external preparation, a skin external preparation can be applied to a desired wound site | part and can also be used for wound treatment. When collagen, particularly synthetic collagen, is included in the skin external preparation component, the skin external preparation transferred to the wound site is not spread by hand, and a hemostatic effect is produced by leaving it as it is.

  Moreover, you may deform | transform the said embodiment as follows. The external appearance of the external preparation for skin according to this modification is shown in FIG. As shown in FIG. 12, the external preparation for skin 51 according to this modification includes a stamp-like holder 52 and a skin external preparation described later carried on the lower end of the holder 52.

  The holding tool 52 has a two-stage cylindrical shape, and has a cylindrical holding portion 55 that forms a lower side of the step 54, and a cylindrical grip that forms an upper side of the step 54 and protrudes from the holding portion 55. Part 56. On the other hand, the grip part 56 has a diameter smaller than that of the carrier part 55 and has a height that can be easily picked up by a finger. Like the holder 2, the holder 52 is preferably made of a material that can be easily picked with a finger and to which the external preparation for skin is easily fixed. However, at least by the force applied to the outer side surface 57 of the gripping part 56 when picking with the finger. In addition, it is preferable that the external preparation for skin has a strength enough to prevent deformation and collapse.

  The structure of the external preparation for skin 51 is shown in FIG. As in the case of the holder 2 described above, the skin external preparation device 51 carries a sheet-like skin external preparation 61 so as to close the opening at the lower end of the carrying portion 55 as shown in FIG. Since the external preparation for skin 61 is the same as the external preparation for skin 3 described above, detailed description thereof is omitted. The holder 52 has a two-step shape due to the step 54, but as shown in FIG. 13, the lower opening of the carrier 55 and the upper opening of the grip 56 communicate internally. When the skin external preparation 61 is not carried, a hole extending in the vertical direction passes through the holder 52.

  Since the skin external preparation tool 51 according to this modification can be manufactured by the above manufacturing process shown in FIG. 3, for example, the description of the manufacturing process of the skin external preparation tool 51 is omitted.

In the case of the external preparation for skin 51 according to this modification, the external preparation for skin 61 is solidified by freeze-drying in a state where the holder 52 is immersed in an aqueous solution having an appropriate amount of water so as to form the external preparation for skin. 61 is fixed to the carrier 55 of the holder 52. Therefore, even if the skin external preparation 61 has a small absolute amount of the external preparation component and has a low structural strength, if it is carried by the holder 52, it can be easily grasped with the fingers of the holding portion 56 of the holder 52. It can be handled.

  By the way, if it is the skin external preparation tool 51 which concerns on this modification, since the diameter of the holding part 56 is smaller than the diameter of the support part 55, the container which accommodates the skin external preparation tool 51 can be comprised as follows. . That is, in the above-described embodiment, the groove 11 for picking the skin external preparation device 1 with a finger is provided in the tray 5, but the skin external preparation device 51 according to the present modification has a diameter of the gripping portion 56. Since it is smaller than the diameter of the part 55, it is possible to pick the grip part 56 without providing the skin external preparation tool 51 corresponding to the groove 11.

  An example of a container for storing the external preparation for skin 51 is shown in FIG. As shown in FIG. 14, the container 50 for storing the external preparation for skin 51 is a cylindrical container, and includes a container main body 58 for storing the external preparation for skin 51 and a lid 53 for closing the opening of the container main body 58. .

  FIG. 15 is a cross-sectional view of the container 50 in which the external skin preparation tool 51 is housed. The lid 53 seals the inside of the container main body 58 by screwing and tightening the female screw 60 of the lid 53 to the male screw 59 provided in the container main body 58. The lid 53 is not limited to being screwed with the container body 58 with a screw. For example, the lid 53 may be engaged with the container body 58 when the lid 53 is pressed against the container body 58. Good.

  The male screw 59 and the female screw 60 are located at approximately the middle height of the container body 58. Therefore, when the lid 53 is removed, the gripping portion 56 of the external skin preparation tool 51 housed in the container main body 58 is protruded from the opening of the container main body 58, and the gripping portion 56 can be easily picked. It is. Further, the container 50 is designed such that when the container main body 58 is closed with the lid 53, the height of the container 50 is substantially the same as that of the external skin preparation tool 51. Therefore, when the container main body 58 is closed with the lid 53, the skin external preparation tool 51 accommodated in the container 50 is sandwiched between the lid 53 and the container main body 58 and supported. When transporting, it is possible to protect the freeze-dried external preparation for skin 61 from impact.

  If the skin external preparation 51 is housed in the container 50 configured in this manner, the airtightness inside the container body 58 is maintained by the lid 53, and therefore when using a non-airtight container such as the tray 5 described above. This eliminates the need for a sealing bag or the like.

  By the way, when manufacturing the external skin preparation device 1 according to each of the above embodiments, the center portion is one step lower than the edge portion, and the two surfaces of the first bottom surface 9 and the second bottom surface 10 are used. The holder 2 is disposed in the storage portion 6 in which the bottom surface 8 is configured, and the skin external preparation 3 is formed by injecting an aqueous solution of the skin external preparation component. However, if the holder is configured as follows, it is possible to inject an aqueous solution of an external preparation for skin and freeze-dry it to form an external preparation for the skin even if the bottom is a flat storage section. It is.

  Hereinafter, using a modified example of the above-mentioned skin external preparation tool 51, the holder is housed in the container body of the container having a flat bottom surface, an aqueous solution of the skin external preparation component is injected, and the injected aqueous solution is freeze-dried to externally apply the skin. A method for forming the agent will be described. In addition, although the manufacturing process shown below uses the modification of the skin external preparation tool 51, it is applicable similarly to the skin external preparation tool 1 which concerns on embodiment, and its modification.

Before describing the manufacturing process according to this modification, a holder used in the manufacturing process will be described. FIG. 16A is a perspective view of the holder 62 used in the manufacturing process according to this modification, and FIG. 16B is a structural diagram of the holder 62. The holder 62 used in the manufacturing process according to this modification is substantially the same as the holder 52 of the above-described external preparation for skin 51, but the configuration of the carrier is different. That is, the holder 52 of the above-mentioned external preparation for skin 51 has no particular unevenness at the lower end of the carrier 55. However, the holding portion 65 of the holder 62 used in the manufacturing process according to the present modification has a concavo-convex process at the lower end. In addition, the holder 62 is formed of a hydrophilic material so that the aqueous solution of the external preparation component for skin can easily gather in the holder 62, and the storage portion for storing the holder 62 is formed of a hydrophobic material. And The number of irregularities is appropriately determined according to the size of the holder 62 and the concentration of the aqueous solution of the external preparation for skin. Further, the grip portion 66 is the same as the grip portion 56.

  An example of the manufacturing process of the external preparation for skin using the holder 62 configured as described above is shown in FIG. In addition, the example shown below demonstrates as an example the case where the holder 62 is accommodated in the container main body 68 mentioned above, and a skin external preparation tool is manufactured.

  When manufacturing the external preparation for skin using the holder 62, an aqueous solution of the external preparation for skin is injected into the storage portion of the container body 68 (FIG. 17A). Next, the holder 62 is put into the storage part of the container main body 68, and the lower part of the carrying part 65 is immersed in the aqueous solution (FIG. 17B).

  By the way, as described above, the holder 62 is made of a hydrophilic material, and the container body 68 that forms a storage portion for storing the holder 62 is made of a hydrophobic material. Therefore, when the holder 62 is inserted into the storage portion of the container main body 68 into which the aqueous solution of the external preparation component for skin has been injected, due to the interaction between the hydrophobic effect of the container main body 68 and the hydrophilic effect of the holder 62, The aqueous solution of the skin external preparation component passes through the uneven gap, and the aqueous solution of the skin external preparation component gathers inside the carrier 65 (FIG. 17C).

  In this state, the aqueous solution is freeze-dried (FIG. 17D). When freeze-drying, the container main body 68 is cooled in a state where the carrier 65 is immersed in the aqueous solution to freeze the aqueous solution. After the aqueous solution that immerses the lower end of the support 65 is sufficiently frozen, the space in which the container main body 68 is disposed is depressurized and evacuated. And a vacuum state is hold | maintained, supplying the quantity of heat required for the sublimation of the water | moisture content in aqueous solution to such an extent that the frozen aqueous solution does not melt | dissolve. Since the holding tool 62 is open at the upper end of the gripping part 66 and the lower end of the holding part 65, the water in the aqueous solution soaking the lower part of the holding part 65 is sublimated so as to pass through the inside of the holding tool 62. As a result, moisture in the aqueous solution sublimes, and eventually the aqueous solution is freeze-dried to form the external skin preparation 64, thereby completing the external skin preparation tool 63 (FIG. 17 (E)).

  When using the external preparation for skin 63, the grasping portion 66 is picked with a finger and the external preparation for skin 63 is taken out from the container main body 68 (FIG. 17F). Since the external preparation for skin 64 is fixed to the lower portion of the carrier 65 by freeze-drying, when the grasping portion 66 is picked up with a finger and lifted from the container main body 68, the external preparation for skin 64 is removed from the bottom surface of the storage portion of the container main body 68. Peel off. When the external preparation 64 for skin is applied onto the skin moistened by applying lotion or the like while the holder 62 is picked with a finger, the external preparation for skin 64 penetrates into the skin.

  In addition, although the holder 62 mentioned above was formed in the cylindrical shape, this invention is not limited to such an aspect. That is, the holder 62 may have any form as long as it can carry the external preparation for skin, and the form can be selected according to the shape of the skin portion to which the external preparation for skin is applied. The cross section of the holder 62 may be non-circular, for example, as shown in FIG. 18, and may have any shape such as an ellipse, crescent, square, polygon, trapezoid, etc., as shown in FIG. There may be.

Moreover, although the holder 62 mentioned above stood | installed the outer surface of the holding | grip part 66 perpendicular | vertical, this invention is not limited to such an aspect. In other words, the holding tool 62 may have any shape as long as the holding part 66 can hold it. The size of the user's finger or the holding tool 62 may be used.
The form can be selected according to the size. For example, as shown in FIG. 19, the outer surface of the grip portion 66 may be erected obliquely.

  Moreover, although the holding | maintenance tool 62 mentioned above had the cross-sectional shape of the holding | grip part 66 and the cross-sectional shape of the holding | maintenance part 65, this invention is not limited to such an aspect. That is, the holding device 62 may have any form as long as the external preparation for skin can be easily transferred to the skin and can be easily grasped. The shape of the skin portion to which the external preparation for skin is applied and the user's finger The form can be selected according to the size. For example, as shown in FIG. 20, the holder 62 may have a cross-sectional shape of the grip portion 66 and a cross-sectional shape of the support portion 65 that are different from each other.

1, 2, 51, 63 ... skin external preparation tool 2, 22, 52, 62 ... holder 3, 23, 61, 64 ... skin external preparation 4 ... outer peripheral side surface 5, 25 ... -Tray 6, 26 ... Storage part 7 ... Wall surface 8 ... Bottom surface 9 ... First bottom surface 10 ... Second bottom surface 11, 11_C, 31 ... Grooves 12, 32, 53 ... Cover 50 ·· Container 54 ·· Steps 55 and 65 · · Supporting portions 56 and 66 · · Holding portion 57 · · Outer surface 58 and 68 · · Container body 59 · · Male screw 60 · · Internal screw

Claims (5)

An upper and lower ends of the holder are open, and an aqueous solution of a skin external preparation component is injected into a holder having an end capable of gripping the holder at the upper end, and the lower end of the holder is immersed in the aqueous solution,
Freeze-drying the aqueous solution soaking the lower end of the holder;
A method for producing an external preparation for skin. Storing the holder in a storage section for storing the external preparation for skin,
Injecting the aqueous solution into the holder stored in the storage unit, immersing the lower end of the holder in the aqueous solution,
Freeze-drying the aqueous solution soaking the lower end of the holder;
The manufacturing method of the skin external preparation tool of Claim 1 . Inject the aqueous solution of the external preparation for skin into the storage part for storing the external preparation for skin,
A holding tool that is open at both upper and lower ends, a holding tool having an upper end at which the holding tool can be gripped is stored in the storage section, and the lower end of the holding tool is immersed in the aqueous solution,
Freeze-drying the aqueous solution soaking the lower end of the holder;
A method for producing an external preparation for skin. The lower end of the holder has been subjected to uneven processing for fixing the skin external preparation,
The manufacturing method of the external preparation for skin preparations of Claim 3 . The holder is made of a hydrophilic material,
The storage portion is formed of a hydrophobic material,
The manufacturing method of the external preparation for skin as described in any one of Claims 2-4 .

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