JP5888904B2 - 中枢神経移行性評価用プローブ、中枢神経移行性評価方法、及び、中枢神経移行性評価用プローブを用いたスクリーニング方法 - Google Patents

中枢神経移行性評価用プローブ、中枢神経移行性評価方法、及び、中枢神経移行性評価用プローブを用いたスクリーニング方法 Download PDF

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JP5888904B2
JP5888904B2 JP2011187500A JP2011187500A JP5888904B2 JP 5888904 B2 JP5888904 B2 JP 5888904B2 JP 2011187500 A JP2011187500 A JP 2011187500A JP 2011187500 A JP2011187500 A JP 2011187500A JP 5888904 B2 JP5888904 B2 JP 5888904B2
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central nervous
probe
nervous system
transporter
group
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Japanese (ja)
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JP2012184217A (ja
JP2012184217A5 (enExample
Inventor
利男 田中
利男 田中
有平 西村
有平 西村
康人 島田
康人 島田
渡邉　耕平
耕平 渡邉
野本　毅
毅 野本
美絵 岡野
美絵 岡野
太一 新藤
太一 新藤
健 宮▲崎▼
健 宮▲崎▼
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Canon Inc
Mie University
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Canon Inc
Mie University
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Priority to JP2011187500A priority Critical patent/JP5888904B2/ja
Priority to US13/397,759 priority patent/US10227337B2/en
Priority to EP12001025.1A priority patent/EP2489665B1/en
Publication of JP2012184217A publication Critical patent/JP2012184217A/ja
Publication of JP2012184217A5 publication Critical patent/JP2012184217A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/04—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups one >CH- group, e.g. cyanines, isocyanines, pseudocyanines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/4603—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from fish
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2011187500A 2011-02-16 2011-08-30 中枢神経移行性評価用プローブ、中枢神経移行性評価方法、及び、中枢神経移行性評価用プローブを用いたスクリーニング方法 Active JP5888904B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2011187500A JP5888904B2 (ja) 2011-02-16 2011-08-30 中枢神経移行性評価用プローブ、中枢神経移行性評価方法、及び、中枢神経移行性評価用プローブを用いたスクリーニング方法
US13/397,759 US10227337B2 (en) 2011-02-16 2012-02-16 Evaluation probe for central nervous system permeability, evaluation method for central nervous system permeability, and screening method using an evaluation probe for central nervous system permeability
EP12001025.1A EP2489665B1 (en) 2011-02-16 2012-02-16 Evaluation probe for central nervous system permeability, evaluation method for central nervous system permeability, and screening method using an evaluation probe for central nervous system permeability

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011030778 2011-02-16
JP2011030778 2011-02-16
JP2011187500A JP5888904B2 (ja) 2011-02-16 2011-08-30 中枢神経移行性評価用プローブ、中枢神経移行性評価方法、及び、中枢神経移行性評価用プローブを用いたスクリーニング方法

Publications (3)

Publication Number Publication Date
JP2012184217A JP2012184217A (ja) 2012-09-27
JP2012184217A5 JP2012184217A5 (enExample) 2014-10-09
JP5888904B2 true JP5888904B2 (ja) 2016-03-22

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JP2011187500A Active JP5888904B2 (ja) 2011-02-16 2011-08-30 中枢神経移行性評価用プローブ、中枢神経移行性評価方法、及び、中枢神経移行性評価用プローブを用いたスクリーニング方法

Country Status (3)

Country Link
US (1) US10227337B2 (enExample)
EP (1) EP2489665B1 (enExample)
JP (1) JP5888904B2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2370111B1 (en) 2008-12-25 2014-11-05 Canon Kabushiki Kaisha Probe for a biological specimen and labelling method and screening method using the probe
EP2399612B1 (en) * 2009-12-25 2018-02-21 Canon Kabushiki Kaisha Composition for labeling tissues of central nervous system, method for labeling tissues of central nervous system, and screening method using the composition for labeling tissues of central nervous system
JP6057574B2 (ja) * 2012-07-11 2017-01-11 キヤノン株式会社 造血幹細胞識別用プローブ
JP6384821B2 (ja) 2012-10-26 2018-09-05 国立大学法人三重大学 がん細胞阻害薬、がん幹細胞検出用プローブ
JP6327431B2 (ja) 2012-10-26 2018-05-23 国立大学法人三重大学 がん細胞阻害薬、がん幹細胞検出用プローブ
EP2943584B1 (en) 2013-05-30 2019-08-14 Canon Kabushiki Kaisha Macrophage identification agent, and identification method, sorting method, evaluation method, screening method and kit using the macrophage identifier agent

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0403490D0 (en) 2004-02-17 2004-03-24 Daniolabs Ltd Screening methods
JP2006121981A (ja) 2004-10-29 2006-05-18 Research Organization Of Information & Systems ヒトｍｒｐ１阻害剤のスクリーニング方法
JP2009250652A (ja) 2008-04-02 2009-10-29 Fujifilm Corp 細胞内移行性速度を測定することによる機能性物質のスクリーニング法
EP2370110B1 (en) * 2008-12-25 2017-08-02 Canon Kabushiki Kaisha Labeling composition for intraocular tissue, labeling method of intraocular tissue, and screening method
EP2370111B1 (en) 2008-12-25 2014-11-05 Canon Kabushiki Kaisha Probe for a biological specimen and labelling method and screening method using the probe
EP2399612B1 (en) * 2009-12-25 2018-02-21 Canon Kabushiki Kaisha Composition for labeling tissues of central nervous system, method for labeling tissues of central nervous system, and screening method using the composition for labeling tissues of central nervous system
EP2517732B1 (en) 2009-12-25 2016-09-21 Canon Kabushiki Kaisha Transnasal labeling composition for tissues of central nervous system
JP6057574B2 (ja) 2012-07-11 2017-01-11 キヤノン株式会社 造血幹細胞識別用プローブ

Also Published As

Publication number Publication date
US10227337B2 (en) 2019-03-12
EP2489665B1 (en) 2019-10-02
JP2012184217A (ja) 2012-09-27
US20120207683A1 (en) 2012-08-16
EP2489665A1 (en) 2012-08-22

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