JP5877218B2 - ベンチレーターのための噴霧装置及び噴霧装置を有するベンチレーター - Google Patents
ベンチレーターのための噴霧装置及び噴霧装置を有するベンチレーター Download PDFInfo
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- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
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- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0057—Pumps therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0465—Tracheostomy tubes; Devices for performing a tracheostomy; Accessories therefor, e.g. masks, filters
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- A—HUMAN NECESSITIES
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- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
- A61M16/0816—Joints or connectors
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
- A61M16/0816—Joints or connectors
- A61M16/0833—T- or Y-type connectors, e.g. Y-piece
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- A—HUMAN NECESSITIES
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- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
- A61M15/001—Details of inhalators; Constructional features thereof with means for agitating the medicament using ultrasonic means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
- A61M16/18—Vaporising devices for anaesthetic preparations
- A61M16/183—Filling systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
- B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
- B05B17/0646—Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto
Description
これによって引き起こされた遺伝子発現の抑制は、その組成に応じて、様々な病気の治療に役立つオリゴヌクレオチドを作り、また、例えば、呼吸器合胞体ウイルスの治療用のAlN−RSV01、喘息及びアレルギーの治療用のAVE−7279、アレルギー性喘息の治療用のTPI―ASM8、癌の治療用の1018― ISSなどの、多くの化合物が現在臨床試験中である。
Claims (15)
- 噴霧装置をベンチレーション装置(100)に連結するための第一連結部(10)と噴霧装置を患者に至るライン(103)に連結するための第二連結部(31)とを有する本体(1,2)であって、該本体は該第一連結部(10)から該第二連結部(31)に至る流れチャンネルを形成する本体(1、2)と、
流体を霧化するための霧化器(3)であって、該第一連結部(10)と該第二連結部(31)との間の該流れチャンネルに配置され、該流体が該第一連結部から第二連結部に至る流れの方向に実質的に平行に噴霧されるように該霧化器が形成され、流体を霧化するための複数の孔が設けられている振動可能な膜(37)を有する霧化器(3)と、
前記本体(1、2)と連結されて霧化すべき流体を容れる流体容器(14)と、
前記流体が噴霧される噴霧室(38)と
を有するベンチレーターのための噴霧装置において、
前記膜(37)が該流体容器(14)と該噴霧室(38)との間に配置され、
前記噴霧室及び前記第二連結部は前記膜の第一の側に配置され、前記第一連結部は前記第一の側とは反対の前記膜の第二の側に配置され、
a)前記流体容器は、ベンチレーション中でも着脱可能に前記本体に連結され、又は
b)前記流体容器は、ベンチレーション中でも流体連通インターフェースを介して前記流体容器と連通する流体アンプルを容れるように形成され、又は
c)蓋が前記流体容器に連結され、ベンチレーション中でも前記流体容器を前記流体で充填するために取り外し可能であることを特徴とする噴霧装置。 - 前記噴霧室(38)が前記膜(14)と前記第二連結部(31)との間に設けられている請求項1に記載の噴霧装置。
- 前記流体容器(14)は、膜の方向に向くテーパー部(23)を有しており、流体室(24)方向に開き、前記膜により閉じられている請求項1又は2に記載の噴霧装置。
- 前記膜(37)から離れる方向に向く前記テーパー部(23)の少なくとも一部が垂直に対して10°から40°の角度で延びている請求項3に記載の噴霧装置。
- 前記流れチャンネルは、前記膜(37)と前記本体(1,2)との間の半径方向に形成された取巻き流れ部(42、43)を有しており、該流れ部が、前記ベンチレーション装置(100)の患者に至るラインの最小断面積にほぼ相当する面積を有している請求項1ないし4の一つに記載の噴霧装置。
- 前記膜(37)は、前記取巻き流れ部(42,43)の少なくとも一部(42)が前記膜(37)を取り囲むフレーム(19,40)と前記膜(37)との間に形成されるように、スポークにより該フレーム(19,40)内に掛けられている請求項5に記載の噴霧装置。
- 前記膜(37)は、前記第一連結部(10)から前記第二連結部(31)に至る流れの方向に実質的に垂直に配置される、請求項1ないし6の一つに記載の噴霧装置。
- 前記流体連通インターフェースは開孔具により形成され、前記開孔具により開けられる流体アンプルを受けるよう構成される、請求項1ないし7の一つに記載の噴霧装置。
- 前記開孔具は中空スパイクである、請求項8に記載の噴霧装置。
- 前記流体連通インターフェースは中空針(122)及び前記中空針(122)により流体アンプルを受けると開けられるバルブ(123)により形成される、請求項1ないし7の一つに記載の噴霧装置。
- 呼吸気を与えるための給気ライン(101)と排気エアを返すための排気ライン(102)と患者(104)に至る第二ライン(103)とを有するベンチレーション装置と共に、前記請求項1から10のいずれか一つに記載の噴霧装置を有し、前記本体(1,2)の前記第一連結部(10)が少なくとも前記給気ライン(101)に連結されているベンチレーター。
- 前記本体(1,2)の前記第一連結部(10)がさらに、前記排気ライン(102)に連結されており、前記本体の前記第二連結部(31)が前記第二ライン(103)に連結されている請求項11に記載のベンチレーター。
- 前記給気ライン(101)と前記排気ライン(102)が、夫々別の管により形成され、且つ前記噴霧装置の夫々に対応する前記第一連結部(10)の第一連結部材(11)と第二連結部材(12)に連結され、前記ベンチレーション装置(100)は、連続的なバイアス流が生成され、該バイアス流が吸引サイクルの間には、呼吸気と共に前記給気ライン(101)から、前記本体(1,2)の流れチャンネルを通して第二ライン(103)に流れて患者(104)に至り、その他においては、給気ライン(101)と前記噴霧装置の前記第二連結部(31)とは反対側の前記霧化器(3)の側に形成される前記給気ライン(101)から前記排気ライン(102)に至るバイパス(13)を通して前記排気ライン(102)に流れる様に形成された請求項12に記載のベンチレーター。
- 前記給気ライン(101)と前記排気ライン(102)は隔壁により二つの部分に分けられた共通管か前記噴霧装置の前記第一連結部(10)に連結された同心管により形成され、前記ベンチレーション装置(100)は、連続的なバイアス流が生成されて、該バイアス流が吸引サイクルの間には、呼吸気と共に前記給気ライン(101)から、前記本体(1,2)の流れチャンネルを通して第二ライン(103)に流れて患者(104)に至り、その他においては、給気ライン(101)と前記噴霧装置の前記第二連結部(31)とは反対側の前記霧化器(3)の側に形成されるバイパス(13)を通して前記排気ライン(102)に流れるように形成されており、該バイパスは、前記霧化器と前記隔壁の前面か該霧化器に面する同心管の内管との間に形成されている請求項12に記載のベンチレーター。
- 前記吸引サイクルに応答して前記霧化器が起動されることで流体の霧化が該吸引サイクルの間でのみ起きるようにする制御器を更に有している請求項11乃至14の一つに記載のベンチレーター。
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DE102008022987.3 | 2008-05-09 | ||
DE102008022987A DE102008022987A1 (de) | 2008-05-09 | 2008-05-09 | Vernebler für Beatmungsmaschinen und Beatmungsmaschine mit einem solchen Vernebler |
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JP2014077083A Expired - Fee Related JP5877218B2 (ja) | 2008-05-09 | 2014-04-03 | ベンチレーターのための噴霧装置及び噴霧装置を有するベンチレーター |
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EP (3) | EP2548598B1 (ja) |
JP (2) | JP5762283B2 (ja) |
AU (1) | AU2009245802B2 (ja) |
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US20110146670A1 (en) | 2011-06-23 |
US20130174840A1 (en) | 2013-07-11 |
ES2533436T3 (es) | 2015-04-10 |
WO2009135871A1 (de) | 2009-11-12 |
AU2009245802A1 (en) | 2009-11-12 |
EP2848275A3 (de) | 2015-07-08 |
CA2723885A1 (en) | 2009-11-12 |
CA2808171C (en) | 2018-03-20 |
JP5762283B2 (ja) | 2015-08-12 |
JP2011519642A (ja) | 2011-07-14 |
AU2009245802B2 (en) | 2013-11-07 |
US8720435B2 (en) | 2014-05-13 |
ES2533479T3 (es) | 2015-04-10 |
US9095676B2 (en) | 2015-08-04 |
EP2307080B1 (de) | 2015-01-07 |
CA2808171A1 (en) | 2009-11-12 |
EP2548598B1 (de) | 2015-01-07 |
CA2723885C (en) | 2015-11-24 |
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