JP5843089B2 - 球形あるいは非球形ポリマー粒子の合成方法 - Google Patents
球形あるいは非球形ポリマー粒子の合成方法 Download PDFInfo
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
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- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 4
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- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
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- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
- 235000011054 acetic acid Nutrition 0.000 claims description 2
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- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019260 propionic acid Nutrition 0.000 claims description 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 2
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000010419 fine particle Substances 0.000 description 53
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 33
- 239000000178 monomer Substances 0.000 description 17
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- 239000004372 Polyvinyl alcohol Substances 0.000 description 8
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- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 238000004945 emulsification Methods 0.000 description 4
- 230000000379 polymerizing effect Effects 0.000 description 4
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- 239000012798 spherical particle Substances 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- YKYONYBAUNKHLG-UHFFFAOYSA-N n-Propyl acetate Natural products CCCOC(C)=O YKYONYBAUNKHLG-UHFFFAOYSA-N 0.000 description 3
- 229940090181 propyl acetate Drugs 0.000 description 3
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 3
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- 239000011521 glass Substances 0.000 description 2
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- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
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- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003759 ester based solvent Substances 0.000 description 1
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- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 1
- 229940011051 isopropyl acetate Drugs 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
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- 229920001223 polyethylene glycol Polymers 0.000 description 1
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
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Description
Claims (7)
- ギ酸、酢酸及びプロピオン酸の少なくともいずれかのカルボン酸と、メタノール、エタノール、プロパノール及びイソプロパノールの少なくともいずれかのアルコールによって形成されたエステルを含む水溶性有機溶媒に対し、ポリスチレン、ポリメチルメタクリレート、ポリスチレン−co−ジビニルベンゼン、ポリエチレン、ポリエチレンテレフタレート、ポリグリシジルメタクリレート、ポリウレタン、ポリ塩化ビニル又はこれらの任意の共重合体を含むポリマーを溶解することで、ポリマー溶液を調製し、
前記ポリマー溶液及び水溶液を、それぞれマイクロ流路に連続的に導入することで、マイクロ流路内において液滴を形成し、
前記液滴中に含まれる前記水溶性有機溶媒が、前記水溶液中に溶解することによって、ポリマー粒子が形成される、非球形ポリマー粒子の合成方法であって、
前記水溶液及び前記ポリマー溶液の少なくともいずれかに、あらかじめ界面活性剤及び分散安定剤の少なくともいずれかが溶解されており、
前記マイクロ流路は、前記水溶性有機溶媒を導入するための入口、前記水溶液を導入する複数の入口、部分的に細くなっている合流部付近に設けられるオリフィス部、前記オリフィス部の下流の流路部、及び出口と、を備えて構成されており、
前記ポリマー粒子の形状は、半球形、あるいは球に対しクレーター状の欠落を有する形状のいずれかである非球形ポリマー粒子の合成方法。 - 形成された前記ポリマー粒子を含む混合溶液に対し、大量の希釈水溶液を加えた後に、前記水溶液、前記希釈水溶液、および前記水溶性有機溶媒を除去する請求項1に記載の非球形ポリマー粒子の合成方法。
- 前記水溶性有機溶媒とは、室温において、純水に対し1から100重量%の範囲で溶解する有機溶媒である請求項1又は2に記載の非球形ポリマー粒子の合成方法。
- 前記水溶性有機溶媒とは、溶解パラメーターが15から25(MPa1/2)の範囲にある有機溶媒である請求項1乃至3のいずれか1項に記載の非球形ポリマー粒子の合成方法。
- 前記ポリマー溶液中に含まれるポリマー濃度は、10重量%以下である請求項1乃至4のいずれか1項に記載の非球形ポリマー粒子の合成方法。
- 前記ポリマー粒子の平均直径は、10ミクロン以下である請求項1乃至5のいずれか1項に記載の非球形ポリマー粒子の合成方法。
- 前記ポリマー粒子は、その直径の変動係数が10%以下である請求項1乃至6のいずれか1項に記載の非球形ポリマー粒子の合成方法。
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JP2016054696A (ja) * | 2014-09-10 | 2016-04-21 | 国立大学法人 千葉大学 | 細胞培養方法 |
JP7022984B2 (ja) * | 2018-02-23 | 2022-02-21 | 大川原化工機株式会社 | ポリマー粒子の製造方法及び粒子製造装置 |
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JPS5190352A (ja) * | 1975-02-06 | 1976-08-07 | Shinkyujogoseijushiryushinoseizohoho | |
JP4186637B2 (ja) * | 2002-11-06 | 2008-11-26 | 東ソー株式会社 | 粒子製造方法及びそのための微小流路構造体 |
JP2005264120A (ja) * | 2004-03-22 | 2005-09-29 | Sharp Corp | ポリマー微粒子の製造方法。 |
JP4849828B2 (ja) * | 2005-06-10 | 2012-01-11 | 株式会社リコー | トナーの製造方法及びトナー |
JP5350620B2 (ja) * | 2006-11-24 | 2013-11-27 | キヤノン株式会社 | 粒子の製造方法、及び粒子 |
JP2008239902A (ja) * | 2007-03-28 | 2008-10-09 | Fujifilm Corp | ポリマー微粒子及びその製造方法 |
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