JP5840609B2 - イメージングに用いるパーフルオロ化合物 - Google Patents

イメージングに用いるパーフルオロ化合物 Download PDF

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Publication number
JP5840609B2
JP5840609B2 JP2012522296A JP2012522296A JP5840609B2 JP 5840609 B2 JP5840609 B2 JP 5840609B2 JP 2012522296 A JP2012522296 A JP 2012522296A JP 2012522296 A JP2012522296 A JP 2012522296A JP 5840609 B2 JP5840609 B2 JP 5840609B2
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contrast agent
fmri
imaging
combination
perfluoro
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English (en)
Japanese (ja)
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JP2013500959A (ja
JP2013500959A5 (enExample
Inventor
イルディリム，ムハメド
グリュル，ホルガー
マティアス ヨハネス ニコラース ラメリクス，ルドルフ
マティアス ヨハネス ニコラース ラメリクス，ルドルフ
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Koninklijke Philips NV
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Koninklijke Philips NV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1809—Micelles, e.g. phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1878—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles the nanoparticle having a magnetically inert core and a (super)(para)magnetic coating
    • A61K49/1881—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles the nanoparticle having a magnetically inert core and a (super)(para)magnetic coating wherein the coating consists of chelates, i.e. chelating group complexing a (super)(para)magnetic ion, bound to the surface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2012522296A 2009-07-31 2010-07-21 イメージングに用いるパーフルオロ化合物 Expired - Fee Related JP5840609B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09166955.6 2009-07-31
EP09166955 2009-07-31
PCT/IB2010/053321 WO2011013038A2 (en) 2009-07-31 2010-07-21 Perfluoro compounds for use in imaging

Related Child Applications (1)

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JP2015221770A Division JP2016029098A (ja) 2009-07-31 2015-11-12 イメージングに用いるパーフルオロ化合物

Publications (3)

Publication Number Publication Date
JP2013500959A JP2013500959A (ja) 2013-01-10
JP2013500959A5 JP2013500959A5 (enExample) 2014-12-18
JP5840609B2 true JP5840609B2 (ja) 2016-01-06

Family

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JP2012522296A Expired - Fee Related JP5840609B2 (ja) 2009-07-31 2010-07-21 イメージングに用いるパーフルオロ化合物
JP2015221770A Pending JP2016029098A (ja) 2009-07-31 2015-11-12 イメージングに用いるパーフルオロ化合物

Family Applications After (1)

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JP2015221770A Pending JP2016029098A (ja) 2009-07-31 2015-11-12 イメージングに用いるパーフルオロ化合物

Country Status (5)

Country Link
US (1) US20120128589A1 (enExample)
EP (1) EP2459235B1 (enExample)
JP (2) JP5840609B2 (enExample)
CN (1) CN102497888B (enExample)
WO (1) WO2011013038A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101906574B1 (ko) * 2013-01-15 2018-10-10 주식회사 엘지생활건강 발수성을 가지는 칫솔모 및 이를 포함하는 칫솔
CN118859065A (zh) * 2024-07-01 2024-10-29 中国科学院精密测量科学与技术创新研究院 一种利用凝血级联放大提升19f mri肿瘤信噪比的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4453028A (en) * 1982-03-29 1984-06-05 Lagow Richard J Perfluorinated compounds with cyclohexyl groups
US5236694A (en) 1990-02-21 1993-08-17 The Board Of Regents, The University Of Texas System 19f labelled dextrans and antibodies as nmr imaging and spectroscopy agents
US5571498A (en) 1994-06-02 1996-11-05 Hemagen/Pfc Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).
US6167887B1 (en) * 1997-11-21 2001-01-02 Synthetic Blood International, Inc. Selected C-10 perfluorinated hydrocarbons for liquid ventilation and artificial blood
US7220401B2 (en) * 1999-09-24 2007-05-22 Barnes-Jewish Hospital Blood clot-targeted nanoparticles
US6676963B1 (en) * 2000-10-27 2004-01-13 Barnes-Jewish Hospital Ligand-targeted emulsions carrying bioactive agents
US6574497B1 (en) * 2000-12-22 2003-06-03 Advanced Cardiovascular Systems, Inc. MRI medical device markers utilizing fluorine-19
US6869591B2 (en) * 2002-03-26 2005-03-22 Barnes-Jewish Hospital Paramagnetic particles that provide improved relaxivity
US8777889B2 (en) * 2004-06-15 2014-07-15 Ceramatec, Inc. Apparatus and method for administering a therapeutic agent into tissue
EP1817098A1 (en) 2004-10-29 2007-08-15 Koninklijke Philips Electronics N.V. Method and apparatus for the preparation of dispersions of particles for use as contrast agents in ultrasound imaging
WO2007127958A2 (en) * 2006-04-27 2007-11-08 Barnes-Jewish Hospital Detection and imaging of target tissue
JP5366824B2 (ja) * 2006-12-19 2013-12-11 コーニンクレッカ フィリップス エヌ ヴェ ２次元ビデオの３次元ビデオへの変換方法及びシステム
EP2130058B1 (en) 2007-03-19 2013-05-15 Koninklijke Philips Electronics N.V. Fast magnetic resonance spectroscopic imaging
EP1985312A1 (en) 2007-04-25 2008-10-29 Koninklijke Philips Electronics N.V. T1 reduction in 19F magnetic resonance imaging (MRI)
KR101005561B1 (ko) * 2008-06-21 2011-01-05 한국생명공학연구원 광학특성 나노입자 및 퍼플루오로카본으로 구성된 나노에멀젼을 이용한 다중모드 조영 방법
CN102395548A (zh) * 2009-04-15 2012-03-28 奥斯金生医公司 全氟化碳类乳液

Also Published As

Publication number Publication date
CN102497888B (zh) 2014-10-29
CN102497888A (zh) 2012-06-13
EP2459235B1 (en) 2014-04-23
JP2013500959A (ja) 2013-01-10
JP2016029098A (ja) 2016-03-03
WO2011013038A2 (en) 2011-02-03
EP2459235A2 (en) 2012-06-06
US20120128589A1 (en) 2012-05-24
WO2011013038A3 (en) 2011-05-05

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