JP5828120B2 - Drug mixing apparatus and drug mixing method - Google Patents

Description

  The present invention relates to a drug mixing apparatus and a drug mixing method for sucking and mixing a drug such as an injection drug in a syringe in the field of medicine and the like.

  When a medicine is applied to a hospitalized patient or the like in a hospital or the like, a mixture of several kinds of medicines taken out from different medicine containers may be applied. In many cases, the operation of mixing the medicine taken out from the medicine container is dependent on the hands of a nurse or a pharmacist. As an example of the operation of mixing the medicine, there is an operation of sucking the medicine by inserting an injection needle or the like into the medicine container. At this time, since a certain level of force is required for suction, such as suction of high-viscosity chemicals such as butter sugar, or suction from a vial container that requires internal pressure adjustment, mixing these drugs is a heavy work load. It has become. Furthermore, among drugs applied at hospitals, there are drugs that should be handled with due consideration to safety, such as anticancer drugs. Therefore, it is desired to develop a drug mixing apparatus that can be handled safely and requires less work load.

  FIG. 10 shows a plan view of a conventional drug mixing device 10. A drug mixing apparatus 10 shown in FIG. 10 is configured such that a drug container (not shown) such as a vial stored in the rack 2a of the inventory chamber 2 is taken out into the processing chamber 3 by the robot manipulator system 1 and then a syringe is used in the processing chamber 3. (Not shown) is used to take out an appropriate amount of drug from the drug container into a syringe or the like. Here, the pressure in the processing chamber 3 is maintained at a pressure slightly lower than the atmospheric pressure so that the drug is difficult to diffuse outside the drug mixing device 10 even when the drug leaks from the drug container or the like in the process chamber 3. ing. Further, the inside of the inventory chamber 2 is maintained at a pressure slightly higher than the atmospheric pressure, and even when the medicine leaks from the medicine container or the like in the processing chamber 3, the medicine is in a vapor state and hardly enters the inventory chamber 2. Therefore, the outside of the container such as a medicine container stored in the inventory chamber 2 is hardly contaminated with the medicine.

  In the medicine mixing apparatus 10, based on the prescription information displayed on the monitor 4 that can also be used as a control system, the medicine container and the infusion bag (not shown) are each taken out by the robot manipulator system 1 and transported into the processing chamber 3. . Here, the medicine container is selected from the rack 2a disposed in the inventory chamber 2, and the infusion bag is a syringe for sucking medicine from the rack 2b and a medicine for diluting the medicine. Then, in the processing chamber 3, the drug container and the syringe are moved to the needle raising syringe manipulator 5 by the robot manipulator system 1. Then, a predetermined dose of drug in the drug container is sucked into the syringe. Thereafter, the syringe is transported to the decapper station 6 by the robot manipulator system 1 and the needle is removed from the syringe, and transported to the syringe capper station 7 and a cap is attached to the syringe without the needle. Thereafter, the syringe is transported to the weighing station 8 and measured for weight, and then transported to the labeling station 9 where a printed label (identification label: ID label) is applied. In this state, it is thrown into the syringe discharge chute 11 and taken out by a pharmacist or the like.

  Alternatively, the robot manipulator system 1 may be used to transport a syringe containing a medicine to the needle lowering syringe manipulator 12 and discharge it to an infusion bag or the like. In this case, the infusion bag is transported to the port cleaner station 13.

  In the conventional drug mixing apparatus 10, the drug is mixed in the substantially aseptic stock chamber 2 or the processing chamber 3, and the pressure of the process chamber 3 that actually mixes the drug is lower than the atmospheric pressure. Set to pressure. For this reason, even if the drug leaks in the processing chamber 3, it does not leak out of the processing chamber 3. Thereby, it is said that a safe drug mixing operation can be performed without adversely affecting the environment where the drug mixing device 10 is installed (see, for example, Patent Document 1).

Special table 2009-504199

  However, in the conventional drug mixing apparatus described above, the leakage of the drug due to the so-called aerosol when the drug is sucked from the drug container into the syringe is prevented only by preventing the drug from leaking out of the processing chamber. Not considered.

  The present invention solves this problem, and provides a drug mixing device and a drug mixing method that prevent a drug from leaking from a drug container due to aerosol and prevent a drug from leaking from the drug mixing device to the outside. The purpose is to do.

To achieve the above object, the drug mixing device of the present invention includes a storage area for arranging at least one of a drug container, a syringe and an infusion bag, and among the drug container, the syringe and the infusion bag. A transport area for transporting at least one of the above and a drug mixing area provided adjacent to the transport area and provided with a mixing engine for sucking and mixing the drug from the drug container by the syringe. The outer cylinder part and the inner cylinder part have an exhaust port and an intake port, respectively , in the first closed space constituted by the storage area, the transport area and the drug mixing area, and in the drug mixing area When the second closed space defined inside the first closed space is defined, the second closed space is an outer cylinder portion of the mixing engine. Is defined between two cylindrical beauty inner cylindrical portion, the drug in the second closed space is mixed, in order to prevent the influence of the dust generated by the influence and the inner cylindrical portion of the aerosol generated in the outer cylindrical portion The gas flowing through the second closed space and the gas flowing through the inner cylinder portion are separated from each other by exhausting through the exhaust port and intake through the intake port .

  In order to achieve the above object, the drug mixing method of the present invention includes a holder after transferring at least one of a drug container, a syringe, and an infusion bag into a mixing engine in a drug mixing area via a transfer area. And a conveying step that is held at a position, and after closing and closing the door of the mixing engine, gas is supplied from the upper part of the mixing engine and exhausted from the lower part of the mixing engine, and the gas is discharged from the upper part. At least one of a gas flow step that flows at a predetermined speed in the lower part, a drug mixing step of sucking and mixing the drug from the drug container into the syringe, and a pressure and a flow rate of the gas are changed in the mixing engine And a pressure adjustment step for adjusting the pressure value of the gas in the mixing engine. That.

  According to the drug mixing device and the drug mixing method of the present invention, it is possible to prevent the drug from leaking from the drug container due to the aerosol. In addition, leakage of the medicine from the medicine mixing device to the outside can be prevented.

BRIEF DESCRIPTION OF THE DRAWINGS It is a schematic block diagram of the chemical | medical agent mixing apparatus concerning Embodiment 1 of this invention, (a) The front view of a chemical | medical agent mixing apparatus, (b) The top view of a chemical | medical agent mixing apparatus. BRIEF DESCRIPTION OF THE DRAWINGS It is a schematic block diagram of the mixing engine and melt | dissolution engine which are arrange | positioned at the chemical | medical agent mixing area of the chemical | medical agent mixing apparatus concerning Embodiment 1 of this invention, (a) Side view of a mixing engine, (b) Side view of a dissolution engine. (A)-(c) The schematic diagram which shows a mode that mixing operation is performed in the mixing engine of the chemical | medical agent mixing apparatus concerning Embodiment 1 of this invention. The perspective view which shows schematic structure of the mixing engine of the chemical | medical agent mixing apparatus concerning Embodiment 1 of this invention. BRIEF DESCRIPTION OF THE DRAWINGS It is a figure which shows schematic structure of the mixing engine of the chemical | medical agent mixing apparatus concerning Embodiment 1 of this invention, (a) Top view which shows schematic structure of mixing engine, (b) Distribution of flow velocity of gas in mixing engine is modeled Top view The side view which shows typically the flow of the gas inside the mixing engine of the chemical | medical agent mixing apparatus concerning Embodiment 1 of this invention. Sectional drawing which shows typically the gas flow inside the chemical | medical agent mixing apparatus concerning Embodiment 1 of this invention. The flowchart of the chemical | medical agent mixing method concerning Embodiment 1 of this invention. It is a figure which shows each state of the chemical | medical agent mixing method concerning Embodiment 1 of this invention, (a)-(g) The top view inside a mixing engine in each state Plan view of a conventional drug mixing device

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. In addition, the same code | symbol is attached | subjected to the same component and description may be abbreviate | omitted. Further, the drawings schematically show the respective constituent elements mainly for easy understanding. In order to clarify the correspondence between the drawings, the XYZ axes are shown in each drawing.

(Embodiment 1)
1A and 1B are schematic configuration diagrams of a drug mixing device 20 according to a first embodiment of the present invention. FIG. 1A shows a front view of the drug mixing device 20, and FIG. 1B shows a plan view of the drug mixing device 20. 2A and 2B show a mixing engine 22 arranged in the drug mixing area 101 of the drug mixing device 20 according to the first embodiment of the present invention and a dissolving engine 23 arranged in the drug dissolving area 102. FIG. It is a schematic block diagram. FIG. 2A is a side view of the mixing engine 22, and FIG. 2B is a side view of the melting engine 23.

  As shown in FIGS. 1A and 1B, the medicine mixing device 20 shown in the first embodiment includes a storage area 103, a transport area 104, a medicine mixing area 101, and a medicine dissolving area 102. ing. Here, the storage area 103 is an area for arranging at least one of the drug container 26, the syringe 27, and the infusion bag 28. The transport area 104 is an area for transporting at least one of the medicine container 26, the syringe 27, and the infusion bag 28 disposed in the storage area 103, for example. The medicine mixing area 101 is disposed adjacent to the transport area 104 and is an area for sucking the medicine from the medicine container 26 by the syringe 27 and mixing the medicine. The drug dissolution area 102 is an area that is arranged adjacent to the transport area 104 and is used for dissolving the drug sucked into the syringe 27 in physiological saline in the infusion bag 28 or the like. In the first embodiment, the drug mixing area 101 and the drug dissolving area 102 are provided. However, depending on the purpose of the drug mixing device 20, the drug mixing area 101 is provided instead of the drug dissolving area 102, and two locations are provided. It is also possible to adopt a configuration such as mixing medicines with.

  Here, as shown in FIG. 1B, a space including the storage area 103, the transport area 104, the medicine mixing area 101, and the medicine dissolving area 102 is defined as a first closed space 29. In addition, a space including the medicine mixing area 101 and the medicine dissolving area 102 is further defined as a second closed space 30 disposed inside the first closed space 29.

  In the medicine mixing area 101, a mixing engine 22 is arranged as shown in FIG. Although not shown, a dissolution engine 23 is disposed in the drug dissolution area 102 as in the mixing engine 22 of FIG. For example, the mixing engine 22 performs an operation of mixing the medicine by sucking the medicine from the medicine container 26 with the syringe 27. In addition, the dissolution engine 23 performs an operation of, for example, discharging the drug from the syringe 27 to the infusion bag 28 and dissolving the drug in physiological saline or the like in the infusion bag 28. The drug container 26, the syringe 27, and the infusion bag 28 are for performing the mixing operation or the dissolution operation with the dissolution engine 23.

  In the drug mixing area 101, the drug container 26, the syringe 27, and the infusion bag 28 are carried into the mixing engine 22 from the opening / closing mechanism 22d. When the opening / closing mechanism 22d is closed after the loading, the inside of the mixing engine 22 becomes a second closed space 30a sealed by the outer wall 22c and the opening / closing mechanism 22d. In the drug dissolution area 102, the drug container 26, the syringe 27, and the infusion bag 28 are carried into the dissolution engine 23 from the opening / closing mechanism 23d. When the opening / closing mechanism 23d is closed after the loading, the inside of the melting engine 23 becomes a second closed space 30b sealed by the outer wall 23c and the opening / closing mechanism 23d. By comprising in this way, the chemical | medical agent mixing apparatus 20 becomes the structure sealed double closed from the exterior by the 1st closed space 29 and the 2nd closed space 30 (2nd closed space 30a, 30b). ing.

  In addition, the drug mixing device 20 includes a configuration that controls the gas exhaust speed of the drug mixing area 101 and the drug dissolving area 102 to control the atmospheric pressure in the second closed spaces 30a and 30b. Specifically, when a mixing operation is performed in the medicine mixing area 101, gas is taken into the inside from the upper part 101a, the gas is mainly flowed through the space where the medicine is sucked or discharged by the syringe 27, and the gas is sent from the lower part 101b. Is configured to exhaust the air to the outside. Similarly, when performing a dissolution operation in the drug dissolution area 102, the gas is taken into the inside from the upper part 102a, the gas is mainly flowed through the space where the drug is dissolved by the syringe 27, and the gas is exhausted to the outside from the lower part 102b. Is provided.

  With this configuration, the drug mixing device 20 can control the atmospheric pressure in the second closed spaces 30a and 30b (hereinafter, a combination of these is referred to as the second closed space 30). For example, the pressure of the gas inside the drug container 26 can be controlled. From the value, the pressure value of the gas in the second closed spaces 30a and 30b can be increased. With such a relationship of pressure values, the medicine and gas in the medicine container 26 are in a so-called aerosol state and are not pushed out into the second closed spaces 30a and 30b. Therefore, the leakage of the medicine from the medicine container 26 due to the aerosol can be prevented. In addition, the work space (second closed space 30) for sucking the medicine into the syringe 27 has a structure that is double-closed from the outside of the medicine mixing device 20. With such a structure, even if a small amount of medicine leaks into the mixing engine 22 or the dissolution engine 23, leakage of the medicine to the outside of the medicine mixing device 20 can be reliably prevented.

  Next, the basic operation of the medicine mixing device 20 according to the first embodiment will be described.

  First, as shown in FIGS. 1 (a) and 1 (b), necessary drug containers 26, syringes 27, infusion bags 28, and the like are previously carried into the storage area 103 from the outside of the drug mixing device 20, and the drug mixing device. 20. For example, the medicine is mixed using the mixing engine 22 in the medicine mixing area 101. Specifically, the medicine container 26 and the syringe 27 necessary for the medicine mixing operation are taken out from the storage area 103 using the robot arm 31 in the transport area 104 and carried into the mixing engine 22. As shown in FIG. 2A, the medicine container 26 and the syringe 27 carried in are held by a holder 33 attached to a cylindrical wall surface 32 inside the mixing engine 22. Here, the holder 33 is moved in the vertical direction indicated by an arrow 34 by using a moving mechanism provided in the holder 33 holding the syringe 27. In the mixing engine 22, the needle 27 a at the tip of the syringe 27 is inserted into the drug container 26 by the vertical movement indicated by the arrow 34 to suck the drug.

  Thereafter, in order to dissolve the syringe 27 that has sucked the drug in, for example, physiological saline in the infusion bag 35, the robot arm is moved from the mixing engine 22 shown in FIG. 2 (a) to the dissolving engine 23 shown in FIG. 2 (b). Use 31 to move. Specifically, the syringe 27 that sucks the drug from the drug container 26 in the mixing engine 22 is moved using the robot arm 31 and attached to the holder 33 in the dissolution engine 23.

  Then, as shown in FIG. 2B, the needle 27 a at the tip of the syringe 27 is inserted into the infusion bag 35 by the moving mechanism of the holder 33 that moves in the vertical direction indicated by the arrow 36. After the insertion, the medicine sucked into the syringe 27 is injected into the infusion bag 35, and the medicine is dissolved in, for example, physiological saline. In this way, the drug is mixed and dissolved in the drug mixing device 20 via the syringe 27.

  Further, as shown in FIG. 1B, a shaker 37 is disposed in the first closed space 29 of the drug mixing device 20. The shaker 37 vibrates the drug in order to dissolve and mix the solid drug in the liquid drug when the liquid drug and the solid drug such as particulate matter are mixed inside the drug container 26 and the syringe 27. Give.

  Further, a weighing meter 38 is arranged in the first closed space 29 so that a weight difference between the medicine before sucked by the syringe 27 and the medicine after sucked by the syringe 27 can be confirmed.

  Further, an inspector 39 for recognizing the type and amount of the medicine by recognizing the appearance of the medicine container 26 and an ID label such as a barcode is also provided in the medicine mixing device 20. In addition, a trash box 40 for discarding the used syringe 27 and the needle 27a is also arranged.

  Further, the drug information such as the content of the mixing operation performed in the drug mixing device 20 and the type and amount of the drug to be handled is displayed on the display unit 41 such as a liquid crystal display disposed on the upper front of the drug mixing device 20. The A simple manual for handling the drug mixing device 20 and tools necessary for maintenance are stored in the drawer 42 and the like.

  FIGS. 3A to 3C are schematic views showing a state where a mixing operation is performed in the mixing engine 22 of the medicine mixing device 20 according to the first embodiment of the present invention.

  As shown in FIG. 3A, in the mixing region 22a of the mixing engine 22, the medicine container 26 is held in a holder 33 (not shown in FIG. 3A) in an inverted state. Then, the needle 27a at the tip of the inverted syringe 27 is inserted into the drug container 26 from the lower part of the drug container 26, and the drug 26a is sucked. FIG. 3B shows a state in which the needle 27 a of the syringe 27 is pulled out from the drug container 26 after a predetermined appropriate amount of drug 26 a is sucked into the syringe 27.

  Here, the case where the medicine 26a is simply sucked into the syringe 27 without performing the pumping operation in the state shown in FIG. The pumping operation is an operation for injecting the gas in the syringe 27 into the drug container 26 so as to correspond to the drug sucked into the syringe 27. When the pumping operation is not performed, the pressure in the internal space 26b of the medicine container 26 is lower than the pressure when the medicine 26a is placed in the medicine container 26 and sealed. In this state, when a high-pressure gas is injected into the internal space 26b of the medicine container 26 by the syringe 27, the medicine 26a from the inside of the medicine container 26 is, for example, as a droplet 26c, as shown in FIG. It leaks into the chamber 22b outside the drug container 26. Such a phenomenon is called “aerosol phenomenon” (hereinafter referred to as “aerosol”). When the medicine 26a has toxicity, it is necessary to treat the liquid leaked by the aerosol so as not to touch the human body. FIG. 3C shows a state in which the above-described aerosol is generated in the chamber 22b when the needle 27a of the syringe 27 is pulled out from the drug container 26. At this time, the pressure in the internal space 26b of the medicine container 26 is higher than the pressure in the chamber 22b. Therefore, it is necessary to control the pressure in the chamber 22b in order to prevent aerosol. Next, the control of this pressure will be specifically described.

  FIG. 4 is a perspective view showing a schematic structure of the mixing engine 22 of the medicine mixing device 20 according to the first embodiment of the present invention. FIGS. 5A and 5B are diagrams showing a schematic structure of the mixing engine 22 of the drug mixing device 20 according to the first embodiment of the present invention. FIG. 5A is a top view showing a schematic structure of the mixing engine 22, and FIG. 5B is a top view schematically showing the distribution of gas flow velocity in the mixing engine 22. Since the melting engine 23 has the same general structure as that of the mixing engine 22, the description thereof is omitted here.

  As shown in FIG. 4, the second closed space 30 a surrounded by the outer wall 22 c of the mixing engine 22 is divided into an outer cylindrical portion 32 a outside the wall surface 32 and an inner cylindrical portion 32 b inside the wall surface by the cylindrical wall surface 32. To be separated. The syringe 27 is held by the upper rotating portion 32c with a holder 33 (not shown in FIG. 4), and the medicine container 26 is similarly held by the lower rotating portion 32d with the holder 33 (not shown in FIG. 4). With this configuration, a mechanism for operating the syringe 27 in the medicine mixing area 101, the holder 33 for holding the medicine container 26 in the outer cylinder part 32a, and the like can be accommodated in the inner cylinder part 32b. Thereby, it can prevent that the dust which arises when various mechanisms in a mechanism operate | move falls on the syringe 27 and the chemical | medical agent container 26, and these are contaminated.

  The inner cylinder portion 32 b exhausts gas from the inner cylinder exhaust port 44 b and takes in air from the intake port 46. The outer cylinder part 32 a exhausts gas from the outer cylinder exhaust port 44 a and takes in air from the intake port 43. By separating the gas flow in this way, it can be configured so that the influence of the aerosol generated in the outer cylinder part 32a and the dust generated in the inner cylinder part 32b does not reach the inner cylinder part 32b and the outer cylinder part 32a.

  Here, as described above, when a plurality of drug mixing areas 101 are arranged instead of the drug dissolving area 102, the mixing operation can be efficiently performed in the plurality of second closed spaces 30a.

  It should be noted that the drug dissolving area 102 for dissolving the drug and the drug mixing area 101 for mixing the drug are preferably disposed in close proximity via the robot arm 31. This is because a series of drug mixing and dissolving operations can be performed in a short time by arranging them in close proximity and shortening the moving distance.

  As shown in FIG. 4, a plurality of intake ports 43 whose opening ratios can be changed in order to take gas into the interior are arranged above the second closed spaces 30 a and 30 b. The opening ratios of the plurality of intake ports 43 are controlled by the control unit 43a. In the medicine mixing device 20, the gas flowing into the second closed space 30 a is configured to flow in a concentrated manner at the site of the syringe 27 sucking the medicine from the medicine container 26 by the intake port 43.

  This configuration will be specifically described with reference to FIGS. 5 (a) and 5 (b). The plurality of holders 33 attached to the wall surface 32 shown in FIG. 5A hold the syringe 27 and the drug container 26, respectively. Then, the needle 27a of the syringe 27 is inserted into the medicine container 26 and sucks the medicine by a predetermined amount. After the suction, when the needle 27a is pulled out from the medicine container 26, the liquid medicine in the medicine container 26 may be scattered around as droplets or gaseous gases. At this time, as shown in FIG. 5 (b), the flow velocity of the gas flowing in the region 45 where the medicine container 26 is arranged and suctioned is increased (for example, 3 m / sec, three times the medium speed). As the distance from 45 is increased, the flow rate of the gas is changed from a medium speed (for example, 1 m / sec in the areas 47 and 48) to a low speed (for example, 0.5 m / sec in the area 49 and 1/2 of the medium speed). Such adjustment of the gas flow velocity is performed by adjusting the opening ratio of the plurality of intake ports 43 in the upper part of the second closed space 30a. In order to adjust the opening ratio of the intake port 43, a filter 43b made of, for example, a metal thin plate is fitted in the intake port 43 as shown in FIG. The filter 43b is formed with a vent hole 43c that penetrates the thin plate. The control unit 43a shown in FIG. 4 controls the flow rate of the gas passing through the filter 43b of the intake port 43 to a predetermined flow rate by opening, closing, or partially opening the vent hole 43c. That is, the larger the number of vent holes 43c opened in the filter 43b, the larger the aperture ratio and the greater the flow velocity. Here, the pressure of the gas is set to be 10 to 20 Pa lower than the pressure at the place where the drug mixing device 20 is disposed.

  The region 45 through which the high-speed gas flows is a space having a sufficient area for mixing the drug in the region where the drug container 26 is disposed, for example, as shown in FIG. 4 area is set. For example, the regions 47 and 48 in which the medium-speed gas flows are set to ¼ regions of the entire cross-sectional area adjacent to the region 45 in which the high-speed gas flows. And the area | region of 1/4 of the remaining whole cross-sectional area is set as the area | region 49 through which a low-speed gas flows, for example.

  Further, these areas may be divided and set so as to include, for example, one holder 33 according to the position of the holder 33. In this case, six areas divided into six equal parts corresponding to the position of the holder 33 shown in FIG. In this case, six intake ports 43 into which the filter 43b shown in FIG. 5B is fitted are arranged in the upper part of each region.

  Further, in order to clearly divide the region and set the difference in the gas flow rate for each region remarkably, for example, a partition plate (not shown) that divides the holder 33 into the rotating portion 32c that supports the syringe 27 shown in FIG. ) May be attached.

  By setting the region for each holder 33 in this way, even if an aerosol is generated in the region where the medicine is mixed, the aerosol can be prevented from adhering to other regions. The gas sucked from the upper intake port 43 is exhausted by the lower exhaust port 44. In FIG. 5A, the medicine container 26 and the syringe 27 are conveyed to the inside from a door 50 that is an opening / closing mechanism 22 d of the mixing engine 22. The door 50 is provided along the outer wall 22c at a position close to the robot arm 31 of the mixing engine 22 so that the medicine container 26, the syringe 27, and the like can be easily conveyed. The door 50 is formed with good airtightness so that the inside of the mixing engine 22 is completely cut off from the outside. When the door 50 is opened and closed, the gas inside the mixing engine 22 has a low flow rate or In a stopped state, the pressure difference between the inside and outside of the door 50 is minimized so that it can be easily opened and closed.

  With the configuration described with reference to FIGS. 4, 5 </ b> A, and 5 </ b> B, the gas in the mixing engine 22 is downflowed. And even if only a trace amount of harmful gas due to the medicine leaks from the medicine container 26 by making the down flow, the gas flowing inside toward the harmful gas concentrates and flows from the upper part to the lower part. It is composed. That is, as compared with other regions in the second closed space 30a, gas concentrates in the region 45 and flows from the upper part to the lower part at a maximum flow rate. Thereby, the harmful gas is quickly exhausted from the second closed space 30a to the exhaust side.

  Further, in the first embodiment, the flow rate ratio is substantially equal to the pressure ratio, and the region 45 where the medicine is mixed is made high speed. This is to prevent the aerosol from diffusing even when the gas is generated in the region 45 and the aerosol is generated. Thereby, it is possible to more reliably prevent harmful gas from adhering to the inside of the drug mixing device 20 and leaking of harmful gas staying inside the drug mixing device 20 to the outside of the drug mixing device 20. In addition to the aerosol, dust and the like are also quickly discharged to the lower portion of the mixing engine 22 using gravity and downflow.

  FIG. 6 is a side view schematically showing a gas flow inside the mixing engine 22 of the drug mixing device 20 according to the first embodiment of the present invention. FIG. 7 is a cross-sectional view schematically showing a gas flow inside the drug mixing device 20 according to the first embodiment of the present invention. Since the melting engine 23 has the same general structure as that of the mixing engine 22, the description thereof is omitted here.

  As shown in FIG. 6, gas 51 and 52 are allowed to flow from the upper part to the lower part through the outer cylinder part 32a and the inner cylinder part 32b separated by the wall surface of the mixing engine 22, respectively. These gases 51 and 52 pass through the base portion 53 of the mixing engine 22 through the respective paths, and merge and mix in the exhaust portion 54.

  FIG. 7 shows the entire gas flow inside the drug mixing device 20. The gas 51 flowing through the outer cylinder part 32 a and the gas 52 flowing through the inner cylinder part 32 b pass through the base part 53 of the mixing engine 22 and merge at the exhaust part 54. Since the gases 51 and 52 at this time are sucked in by the blower fan 60 at the upper part of the medicine mixing device 20, the air is generally a negative pressure rather than the atmospheric pressure. The gases 51 and 52 are pushed out by the fan 60, become positive pressure air, are cleaned by the HEPA filter 55, and are discharged to the outside of the medicine mixing device 20.

  On the other hand, in the first embodiment, in the medicine mixing area 101, the gases 51 and 52 exhausted from the lower part of the second closed space 30a are mixed with the gas 56 exhausted from the lower part of the first closed space 29, It is inhaled as clean gas 57 from the upper part 101a of the medicine mixing area 101. The drug mixing device 20 includes the circulation path 58 in order to allow the normal gas 57 to flow from the upper part 101a of the drug mixing area 101 in this way. With this configuration, harmful gas generated by aerosol or the like is removed by the detoxifying filter 59 provided in the circulation path 58 without leaking out of the drug mixing device 20, and the internal gas can be kept clean and reused. .

  In the medicine mixing device 20, the pressure value of the gas 51 in the second closed space 30 may be greater than or equal to the pressure value of the gas inside the medicine container 26. In the first embodiment, the pressure value of the gas 51 in the second closed space 30a is set, for example, 10 to 20 Pa lower than the pressure value outside the apparatus where the drug mixing apparatus 20 is installed. The pressure value of the gas inside the medicine container 26 is 50 to 100 Pa lower than the pressure outside the medicine container 26 by sucking the medicine. Thereby, the pressure value of the gas 51 is larger than the pressure value of the gas inside the medicine container 26. With this configuration, when the drug is sucked from the drug container 26 by the syringe 27 and the needle 27 a at the tip of the syringe 27 is pulled out, the pressure value of the gas 51 in the second closed space 30 a in which the syringe 27 is disposed is It becomes higher than the pressure value of the internal gas. Therefore, the liquid or gaseous drug does not leak from the drug container 26. In addition, since the pressure difference between the outside and inside of the drug container 26 is 50 to 100 Pa or more, a phenomenon such as aerosol in which the drug leaks from the drug container 26 can be reliably prevented.

  The pressure value of the gas 51 in the second closed space 30a may be not less than the pressure value of the first closed space 29 and not more than the pressure value of the gas inside the medicine container 26. With this configuration, the pressure value of the first closed space 29 can be minimized, and the difference between the gas pressure value inside the drug container 26 and the gas pressure value of the second closed space 30a can be reduced. As a result, it is possible to reliably reduce phenomena such as aerosol in which the drug leaks from the drug container 26.

  Next, the drug mixing method of the first embodiment will be specifically described.

  8 and 9 show each state of the medicine mixing method according to the first embodiment of the present invention. FIG. 9A to FIG. 9G show top views of the inside of the mixing engine 22 in each state.

  As shown in FIG. 8, the medicine mixing method of the first embodiment includes a transport step S10, a gas flow step S11, a medicine mixing step S12, a pressure adjustment step S13, a drawing step S14, and a clean step S15. It is a method provided with.

  Here, the transport step S10 is performed by passing at least one of the medicine container 26, the syringe 27, and the infusion bag 28 disposed in the first closed space 29 shown in FIG. It is a step of transporting to the second closed space 30 in the mixing area 21 and holding it by the holder 33. In the gas flow step S11, the door 50 of the second closed space 30a is closed, the gas is taken into the inside from the upper part of the second closed space 30a, the gas is exhausted to the outside from the lower part, and the gas is given from the upper part to the lower part. It is a step that flows at a speed. The drug mixing step S12 is a step of sucking the drug from the drug container 26 into the syringe 27 or injecting the drug from the syringe 27 into the infusion bag 28. The pressure adjustment step S13 is a step of adjusting the gas pressure value in the second closed space 30a by changing at least one of the gas pressure and the flow rate. The drawing step S14 is a step of drawing the needle 27a of the syringe 27 from the drug container 26 or the infusion bag 28. The clean step S14 is a step of driving an exhaust blower such as the fan 60 to blow gas to at least one of the needle 27a, the medicine container 26, and the infusion bag 28 of the syringe 27. Note that the pressure value in the second closed space 30a is set to be 50 Pa or more larger than the pressure of the gas inside the medicine container 26 by the pressure adjustment step S13. This setting is directly connected to a gas supply source such as a gas cylinder only when, for example, a pressure adjusting valve is attached to the inlet of the gas flowing into the second closed space 30a, or in addition to performing a mixing operation. This can be realized by introducing a gas having a predetermined pressure into the second closed space 30 from the gas pipe.

  Further, as shown in FIG. 8, a flow rate control start step S16 may be provided after the pressure adjustment step S13 and before the extraction step S14. In the flow rate control start step S16, the flow rate is increased in the space near the needle 27a by changing the opening rate of the filter 43b in the upper part of the second closed space 30a where the syringe 27 and the needle 27a are arranged. This is a step for starting to supply gas. In this way, the pressure value in the space where the syringe 27 and the needle 27a are placed is made higher than the pressure value in the space inside the drug container 26 to prevent the drug from leaking due to the aerosol. Furthermore, the needle 27a withdrawn from the drug container 26 or the infusion bag 35 is further driven by the clean step S15 while the surrounding gas flow rate is increased, and the exhaust blower is driven to maintain the gas flow rate for a predetermined time (for example, , About 20 seconds). As a result, even if a very small amount of medicine is leaked due to aerosol or the like, the medicine is quickly exhausted, and the inside of the second closed space 30a is kept clean. After the clean step S15 is completed, the flow rate of the gas in the second closed space 30a returns to the standby state where the mixing operation of the medicine is not performed, and the flow rate and the flow rate are reduced, for example, by the flow rate control end step S17. 0.1 m / sec or less. Furthermore, when taking out the medicine container 26, the syringe 27, and the like from the second closed space 30a to the first closed space 29, the pressure in the second closed space 30a is changed according to need by the pressure release step S18. The pressure is adjusted to be approximately equal to the pressure. By this method, the pressure and flow rate of the gas in the second closed space 30a can be controlled, so that leakage of the drug from the drug container 26 due to the aerosol can be prevented. In addition, since the working space for sucking or extracting the medicine in the syringe 27 is doubled from the outside, leakage of the medicine from the medicine mixing device 20 to the outside can be surely prevented.

  Subsequently, the drug mixing operation according to the first embodiment will be described in detail with reference to FIGS. 9A to 9G. As shown in FIG. 9A, the mixing engine 22 has a door 50 closed to form a second closed space 30a. As shown in FIG. 9 (b), the door 50 is opened, and as shown in FIG. 9 (c), the medicine container 26 and the syringe 27 are transferred from the first closed space 29, for example, from the storage area 103 to the transport area 104. Then, the robot arm 31 transports it to the second closed space 30a (step S10). The drug container 26 and the syringe 27 are held by respective holders 33. Here, the syringe 27 with the needle 27a facing upward is arranged vertically in the vertical direction with the medicine container 26 held upside down. As shown in FIG. 9 (d), the door 50 is closed, the drug container 26 and the syringe 27 are rotated by the rotating part 32c to move to the pumping position, and gas is passed from the upper part to the lower part of the second closed space 30a. Is flown at a predetermined speed (step S11). Then, as shown in FIG. 9 (e), the medicine is pumped and sucked from the medicine container 26 to the syringe 27 (step S12). At substantially the same time as this pumping operation, the pressure value of the second closed space 30a is adjusted by changing at least one of the pressure and flow rate of the gas. Here, for example, the pressure value is adjusted from the atmospheric pressure to a sufficiently low pressure value so as to be lower than the pressure value of the gas in the internal space of the medicine container 26 (step S13). Note that this pressure adjustment is not performed in the entire second closed space 30a but in a part of the space in which the drug container 26 and the like are arranged in the second closed space 30a as described in the explanation of FIG. 5B. It may be done. Moreover, you may supply the gas which raised the flow velocity and the flow volume to the space near the syringe 27 and the needle 27a (step S16). When the pumping operation is completed, it is confirmed that the pressure value is adjusted, and the needle 27a of the syringe 27 is pulled out from the medicine container 26 (step S14). Further, the exhaust blower such as the fan 60 is driven, and gas is blown to the needle 27a and the medicine container 26 of the syringe 27, and even if liquid or gaseous deposits are attached to them, they are blown off and cleaned. Performed (step S15). After cleaning, the gas flow rate and flow rate are returned to the original standby state (step S17).

  And as shown in FIG.9 (f), the chemical | medical agent container 26 and the syringe 27 are rotated by the rotation part 32c, and move to a carrying-out position from a pumping position, and the pressure value of the 2nd closed space 30a is 1st closure. The pressure is adjusted so as to be substantially equal to the pressure value in the space 29 (step S18). Thereafter, the door 50 is opened, and the medicine container 26 and the syringe 27 are taken out from the second closed space 30a and carried out.

  In the pressure adjustment step S13 described above, at least one of the gas pressure and the flow rate is changed so that the gas pressure value in the second closed space 30a is equal to or higher than the gas pressure value inside the drug container 26. It is good also as a method of making it adjust.

  By this method, it is possible to more reliably prevent a phenomenon such as aerosol in which the drug leaks from the drug container 26.

  Further, in the pressure adjustment step S13, the gas pressure and the pressure value of the gas in the second closed space 30a are equal to or higher than the pressure value of the first closed space 29 and equal to or lower than the pressure value of the gas inside the medicine container 26. It is good also as a method of adjusting by changing at least any one among flow volume.

  By this method, the pressure value of the first closed space 29 can be minimized, and the difference between the pressure value of the gas inside the medicine container 26 and the pressure value of the gas in the second closed space 30a can be reduced. As a result, it is possible to reliably reduce phenomena such as aerosol in which the drug leaks from the drug container 26.

  In the above-described drug mixing method, the mixing engine 22 is described as an example to describe the second closed space 30a, and the drug container 26 and the syringe 27 are used to mix the drug. However, in the second closed space 30b, the medicine is dissolved in the same manner by the syringe 27 and the infusion bag 28 inside the dissolution engine 23.

  According to the drug mixing device and the drug mixing method of the present invention, it is possible to prevent the drug from leaking from the drug container due to the aerosol. In addition, leakage of the medicine from the medicine mixing device to the outside can be prevented. This is useful because a pharmacist or nurse can safely and accurately mix drugs in a hospital or the like, and the work burden on the nurse or pharmacist can be reduced.

DESCRIPTION OF SYMBOLS 20 Drug mixing device 22 Mixing engine 22a Mixing area 22b Chamber 22c, 23c Outer wall 22d, 23d Opening / closing mechanism 23 Dissolution engine 26 Drug container 26a Drug 26b Internal space 26c Droplet 27 Syringe 27a Needle 28 Infusion bag 29 1st closed space 30a, 30b Second closed space 31 Robot arm 32 Wall surface 32a Outer cylinder part 32b Inner cylinder part 32c, 32d Rotating part 33 Holder 34, 36 Arrow 35 Infusion bag 37 Shaker 38 Weighing instrument 39 Auditor 40 Trash box 41 Display part 42 Drawer 43, 46 Intake port 43a Control unit 43b Filter 43c Vent hole 44 Exhaust port 44a Outer cylinder exhaust port 44b Inner cylinder exhaust port 45, 47, 48, 49 Region 50 Door 51, 52, 56, 57 Gas 53 Base unit 54 Exhaust unit 55 HEPA filter 58 Circulation path 59 Detoxification filter 60 Fan 101 Drug mixing area 101a, 102a Upper part 101b, 102b Lower part 102 Drug dissolution area 103 Storage area 104 Transport area

Claims (8)

A storage area for storing at least one of a drug container, a syringe and an infusion bag;
A transport area for transporting at least one of the drug container, the syringe and the infusion bag;
A drug mixing area that is disposed adjacent to the transport area and includes a mixing engine for sucking and mixing the drug from the drug container by the syringe; and
The outer cylinder part and the inner cylinder part have an exhaust port and an intake port, respectively.
When the storage area, the transfer area, the first closed space around the mixing engine, and the second closed space configured inside the mixing engine are defined, the second closed space is defined by the mixing engine. Defined between the two cylindrical shapes of the outer cylinder part and the inner cylinder part, the drug is mixed in the second closed space,
In order to prevent the influence of the aerosol generated in the outer cylinder part and the influence of the dust generated in the inner cylinder part, the gas exhausted at the exhaust port and sucked in the intake port and flowing in the second closed space and the inner Separated from the gas flowing in the tube,
Drug mixing device. In the second closed space, a gas is supplied to the inside of the mixing engine, exhausted to the outside of the mixing engine, and a control unit that controls an exhaust speed of the gas.
The drug mixing device according to claim 1. The second closed space is for the drug mixing area for sucking the drug from the drug container by the syringe and mixing the drug, or for discharging and dissolving the drug inside the syringe by the syringe. A plurality of spaces including any of the drug dissolution areas;
The medicine mixing device according to claim 1 or 2. A plurality of intake ports disposed in the second closed space and having an opening ratio that varies;
In the control unit, the opening ratio of the plurality of intake ports is changed.
The drug mixing device according to claim 2. Providing a circulation path for mixing the gas exhausted from the second closed space with the gas exhausted from the first closed space and supplying the mixed gas to the second closed space;
The medicine mixing device according to any one of claims 1 to 4. The pressure value of the gas in the second closed space is not less than the pressure value of the gas in the drug container,
The medicine mixing device according to any one of claims 1 to 5. A transport step of holding at least one of the drug container, the syringe, and the infusion bag by a holder after transporting into the mixing engine in the drug mixing area through the transport area;
After closing and closing the door of the mixing engine, gas is supplied from the upper part of the mixing engine composed of an outer cylinder part and an inner cylinder part, and the gas is exhausted from the lower part of the mixing engine, and the gas is supplied. A gas flow step for flowing from the upper part to the lower part at a predetermined speed;
In the mixing engine, a drug mixing step of sucking and mixing the drug from the drug container to the syringe;
Varying at least one of the pressure and flow rate of the gas, exhausting the exhaust through the exhaust ports of the outer cylinder part and the inner cylinder part, and intake air through the intake ports of the outer cylinder part and the inner cylinder part A pressure adjusting step for separating the gas in the outer cylinder part and the gas in the inner cylinder part in the mixing engine and adjusting the pressure value of at least one of the gases,
Drug mixing method. In the pressure adjustment step, at least one of the pressure and flow rate of the gas is changed so that the pressure value of the gas in the mixing engine is equal to or higher than the pressure value of the gas in the drug container.
The drug mixing method according to claim 7.

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