JP5809068B2 - 免疫抑制−関連疾患の治療 - Google Patents

免疫抑制−関連疾患の治療 Download PDF

Info

Publication number
JP5809068B2
JP5809068B2 JP2011551250A JP2011551250A JP5809068B2 JP 5809068 B2 JP5809068 B2 JP 5809068B2 JP 2011551250 A JP2011551250 A JP 2011551250A JP 2011551250 A JP2011551250 A JP 2011551250A JP 5809068 B2 JP5809068 B2 JP 5809068B2
Authority
JP
Japan
Prior art keywords
cells
blscs
patient
cancer
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2011551250A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012518646A5 (https=
JP2012518646A (ja
Inventor
ワン,ジェームス
チャン,ルーフェン
イェン,ユン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stembios Technologies Inc
Original Assignee
Stembios Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stembios Technologies Inc filed Critical Stembios Technologies Inc
Publication of JP2012518646A publication Critical patent/JP2012518646A/ja
Publication of JP2012518646A5 publication Critical patent/JP2012518646A5/ja
Application granted granted Critical
Publication of JP5809068B2 publication Critical patent/JP5809068B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22Immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/416Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0607Non-embryonic pluripotent stem cells, e.g. MASC
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2011551250A 2009-02-24 2010-02-19 免疫抑制−関連疾患の治療 Expired - Fee Related JP5809068B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/391,581 US8563307B2 (en) 2009-02-24 2009-02-24 Treatment of immunosuppression-related disorders
US12/391,581 2009-02-24
PCT/US2010/024735 WO2010099044A2 (en) 2009-02-24 2010-02-19 Treatment of immunosuppression-related disorders

Publications (3)

Publication Number Publication Date
JP2012518646A JP2012518646A (ja) 2012-08-16
JP2012518646A5 JP2012518646A5 (https=) 2012-11-29
JP5809068B2 true JP5809068B2 (ja) 2015-11-10

Family

ID=42631141

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011551250A Expired - Fee Related JP5809068B2 (ja) 2009-02-24 2010-02-19 免疫抑制−関連疾患の治療

Country Status (7)

Country Link
US (2) US8563307B2 (https=)
EP (1) EP2400971B1 (https=)
JP (1) JP5809068B2 (https=)
CN (1) CN102325537B (https=)
ES (1) ES2582582T3 (https=)
TW (1) TWI496888B (https=)
WO (1) WO2010099044A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563307B2 (en) 2009-02-24 2013-10-22 James Wang Treatment of immunosuppression-related disorders
US8679474B2 (en) 2010-08-04 2014-03-25 StemBios Technologies, Inc. Somatic stem cells
US8741642B2 (en) 2010-10-22 2014-06-03 Virginia Commonwealth University Methods for producing autologous immune cells resistant to myeloid-derived suppressor cells effects
TWI571513B (zh) 2011-09-28 2017-02-21 幹細胞生物科技股份有限公司 體幹細胞及其製備方法
WO2013176785A1 (en) * 2012-05-21 2013-11-28 The Trustees Of Columbia University In The City Of New York Trefoil family factor and uses thereof
WO2014089268A2 (en) 2012-12-06 2014-06-12 StemBios Technologies, Inc. Lgr5+ somatic stem cells
EP2746769A1 (en) * 2012-12-21 2014-06-25 Stembios Technologies, Inc. Method for evaluating effect of action on subject based on stem celldynamics
US9212225B1 (en) * 2014-07-01 2015-12-15 Amphivena Therapeutics, Inc. Bispecific CD33 and CD3 binding proteins
MX2017015380A (es) 2015-05-29 2018-03-28 Amphivena Therapeutics Inc Metodos para utilizar proteinas de enlace biespecificas cd3 y cd33.

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2936171B2 (ja) 1989-09-01 1999-08-23 東ソー株式会社 血清アルブミンの製造方法
US6004807A (en) 1992-03-30 1999-12-21 Schering Corporation In vitro generation of human dendritic cells
US6916654B1 (en) * 1992-06-29 2005-07-12 Oklahoma Medical Research Foundation Universal donor cells
AU6869198A (en) * 1997-03-25 1998-10-20 Morphogenesis, Inc. Universal stem cells
AU1705599A (en) 1997-11-26 1999-06-15 Allegheny University Of The Health Sciences Methods for mobilizing hematopoietic facilitating cells and hematopoietic stem cells into the peripheral blood
CA2347067C (en) 1998-03-31 2013-09-17 Geron Corporation Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer
US6080399A (en) 1998-04-23 2000-06-27 Arch Development Corporation Vaccine adjuvants for immunotherapy of melanoma
JP3553858B2 (ja) 1999-08-25 2004-08-11 東洋紡績株式会社 血管網類似構造体を有する細胞培養用モジュール
US20030161817A1 (en) 2001-03-28 2003-08-28 Young Henry E. Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
US7575921B2 (en) 1999-12-30 2009-08-18 Vbi Technologies, L.L.C. Spore-like cells and uses thereof
US20020151050A1 (en) 2000-10-30 2002-10-17 Vacanti Charles A. Isolation of spore-like cells from tissues exposed to extreme conditions
JP3977136B2 (ja) 2001-05-22 2007-09-19 キヤノン株式会社 コイルユニット
US7316932B2 (en) 2001-10-01 2008-01-08 Stemcell Technologies Inc. Method for separating cells
US7736892B2 (en) 2002-02-25 2010-06-15 Kansas State University Research Foundation Cultures, products and methods using umbilical cord matrix cells
WO2003075016A1 (en) 2002-03-07 2003-09-12 Cambridge University Technical Services Limited (Cuts) Scd fingerprints
EP1509244B1 (en) 2002-06-06 2011-07-27 Immunicum AB New method and composition for producing a cellular allogeneic vaccine
WO2004042023A2 (en) * 2002-11-01 2004-05-21 Five Prime Therapeutics, Inc. Stem cell libraries
US20060252150A1 (en) * 2002-11-08 2006-11-09 Linzhao Cheng Human embryonic stem cell cultures, and compositions and methods for growing same
US20050003533A1 (en) 2003-05-08 2005-01-06 Pawel Kalinski Mature type-1 polarized dendritic cells with enhanced IL-12 production and methods of serum-free production and use
US20090004661A1 (en) 2003-05-26 2009-01-01 Reliance Life Sciences Pvt Ltd. Method of growing mesenchymal stem cells from bone marrow
ES2265199B1 (es) 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
AU2004249812B8 (en) * 2003-06-25 2011-09-15 Ottawa Hospital Research Institute Methods and compositions for modulating stem cell growth and differentiation
US7622108B2 (en) 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
EP1789540B9 (en) * 2004-09-03 2012-02-22 Moraga Biotechnology Inc. Non-embryonic totipotent blastomer-like stem cells and methods therefor
EP2410044B1 (en) 2004-12-29 2022-06-22 Hadasit Medical Research Services And Development Ltd. Stem cells culture systems
US8846395B2 (en) 2005-06-01 2014-09-30 Wisconsin Alumni Research Foundation Generation of mature myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+progenitors
CA2612694C (en) 2005-06-24 2015-10-27 Desert Lake Technologies Purified component of blue-green algae and method of use
WO2007026353A2 (en) 2005-08-29 2007-03-08 Technion Research & Development Foundation Ltd. Media for culturing stem cells
WO2007082177A2 (en) * 2006-01-06 2007-07-19 Mount Sinai School Of Medicine Of New York University Myeloid suppressor cells, methods for preparing them, and methods for using them for treating autoimmunity
CA2640087A1 (en) 2006-01-25 2007-08-02 Mount Sinai School Of Medicine Methods and compositions for modulating the mobilization of stem cells
EP1991666A4 (en) 2006-02-27 2009-06-10 Moraga Biotech Corp NON-EMBRYONIC TOTIPOTENT STEM CELLS OF BLASTOMERIC TYPE AND METHODS
US8337858B2 (en) 2006-06-27 2012-12-25 Nutratec S.R.L. Extracts of Aphanizomenon Flos Aquae and nutritional, cosmetic and pharmaceutical compositions containing the same
EP1894941A1 (en) * 2006-09-01 2008-03-05 Institut Pasteur Treatment of cervical carcinoma with a recombinant adenylate cyclase carrying HPV antigens
US8759090B2 (en) * 2006-10-30 2014-06-24 University Of Central Florida Research Foundation, Inc. Stem cell banking system
US20090104160A1 (en) 2007-02-01 2009-04-23 Moraga Biotechnology Corporation Mobilization of Stem Cells After Trauma and Methods Therefor
US20090053182A1 (en) 2007-05-25 2009-02-26 Medistem Laboratories, Inc. Endometrial stem cells and methods of making and using same
DK2173379T3 (en) 2007-07-02 2015-12-07 Oncomed Pharm Inc Compositions and methods for treatment and diagnosis of cancer
WO2009012357A2 (en) 2007-07-17 2009-01-22 The General Hospital Corporation Methods to identify and enrich for populations of ovarian cancer stem cells and somatic ovarian stem cells and uses thereof
CN101978046A (zh) 2007-10-30 2011-02-16 路易斯维尔大学研究基金会有限公司 非常小的胚胎样(vsel)干细胞的应用和分离
CA2692634C (en) 2007-11-09 2014-05-27 Rnl Bio Co., Ltd Method for isolating and culturing adult stem cells derived from human amniotic epithelium
CA2723765A1 (en) 2008-05-08 2009-11-12 Coretherapix Slu Multipotent adult stem cell population
WO2010039241A1 (en) 2008-09-30 2010-04-08 University Of Louisville Research Foundation, Inc. Methods for isolating very small embryonic-like (vsel) stem cells
WO2010056341A2 (en) 2008-11-12 2010-05-20 The University Of Vermont And State Agriculture College Compositions and methods for tissue repair
CN102333863A (zh) * 2009-01-13 2012-01-25 干细胞生物科技公司 非胚胎干细胞及其用途
ES2579909T3 (es) 2009-02-03 2016-08-17 Koninklijke Nederlandse Akademie Van Wetenschappen Medio de cultivo para células madre epiteliales y organoides que comprenden dichas células madre
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US8563307B2 (en) 2009-02-24 2013-10-22 James Wang Treatment of immunosuppression-related disorders
WO2011119738A2 (en) 2010-03-23 2011-09-29 The Johns Hopkins University Methods of treatment using stem cell mobilizers
US20130149311A1 (en) 2010-05-07 2013-06-13 Institut De Recherches Cliniques De Montreal Gfi1b modulation and uses thereof
US8679474B2 (en) 2010-08-04 2014-03-25 StemBios Technologies, Inc. Somatic stem cells
TWI635177B (zh) 2010-08-04 2018-09-11 幹細胞生物科技公司 體幹細胞
CN102008650B (zh) 2010-12-16 2017-02-15 天津市医药科学研究所 一种治疗肿瘤的复方中药制剂及其制备方法
TWI571513B (zh) 2011-09-28 2017-02-21 幹細胞生物科技股份有限公司 體幹細胞及其製備方法
WO2014089268A2 (en) 2012-12-06 2014-06-12 StemBios Technologies, Inc. Lgr5+ somatic stem cells
JP2015006184A (ja) 2013-06-24 2015-01-15 ステムバイオス テクノロジーズ, インコーポレイテッドStembios Technologies, Inc. 幹細胞及びそのデータを獲得する方法
CN105687245A (zh) 2014-12-13 2016-06-22 干细胞生物科技公司 制备注射液的方法

Also Published As

Publication number Publication date
EP2400971B1 (en) 2016-05-18
US20140030237A1 (en) 2014-01-30
EP2400971A4 (en) 2013-03-27
WO2010099044A2 (en) 2010-09-02
CN102325537B (zh) 2014-07-30
ES2582582T3 (es) 2016-09-13
US20100215622A1 (en) 2010-08-26
US8563307B2 (en) 2013-10-22
EP2400971A1 (en) 2012-01-04
WO2010099044A9 (en) 2010-12-16
TWI496888B (zh) 2015-08-21
US9770473B2 (en) 2017-09-26
CN102325537A (zh) 2012-01-18
JP2012518646A (ja) 2012-08-16
TW201040278A (en) 2010-11-16

Similar Documents

Publication Publication Date Title
JP5809068B2 (ja) 免疫抑制−関連疾患の治療
JP6871899B2 (ja) 補助的免疫抑制処置を行わないmapc療法
Sera et al. Hematopoietic stem cell origin of adipocytes
TW200523368A (en) Multipotent placental stem cell and methods thereof
JP5432527B2 (ja) 脳損傷及び疾患のmapc治療
EP2539436B1 (en) Modulation of macrophage activation
JP2015159895A (ja) 脳梗塞治療のための多能性幹細胞
CA2798895A1 (en) Modulation of splenocytes in cell therapy
Wang et al. Pre-clinical study of human umbilical cord mesenchymal stem cell transplantation for the treatment of traumatic brain injury: safety evaluation from immunogenic and oncogenic perspectives
US20060210544A1 (en) Internally administered therapeutic agents for cranial nerve diseases comprising mesenchymal cells as an active ingredient
CN105055450A (zh) 人宫内膜干细胞在制备治疗卵巢早衰的药物中的应用
WO2023054317A1 (ja) 放射線による神経障害の処置に用いる細胞調製物
WO2017199976A1 (ja) 多能性幹細胞による周産期脳障害の改善及び治療
US20140004087A1 (en) Endometrial regenerative cells for treatment of traumatic brain injury
Serrato López et al. The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine
MOHAMED et al. The role of stem cells on the ovarian failure induced by busulfan in female albino rat
AU2015202292B2 (en) Modulation of macrophage activation
JP2025523021A (ja) 幹細胞由来エクソソームを含む抗癌組成物及びその製造方法
KR101590722B1 (ko) 인간 혈액 유래 혈구 세포괴를 포함하는 신경계 질환 치료용 약학적 조성물
HK1175805B (en) Modulation of macrophage activation
HK1175805A (en) Modulation of macrophage activation
KR20140021156A (ko) 인간 혈액 유래 혈구 세포괴를 포함하는 신경계 질환 치료용 약학적 조성물

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120104

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121010

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20121010

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131224

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140320

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140328

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140418

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20140422

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150106

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150331

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150811

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150910

R150 Certificate of patent or registration of utility model

Ref document number: 5809068

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees