JP5802872B2 - 縮合ジイミダゾジアゼピン化合物並びにその使用及び製造方法 - Google Patents

縮合ジイミダゾジアゼピン化合物並びにその使用及び製造方法 Download PDF

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JP5802872B2
JP5802872B2 JP2011529012A JP2011529012A JP5802872B2 JP 5802872 B2 JP5802872 B2 JP 5802872B2 JP 2011529012 A JP2011529012 A JP 2011529012A JP 2011529012 A JP2011529012 A JP 2011529012A JP 5802872 B2 JP5802872 B2 JP 5802872B2
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exemplary embodiments
certain exemplary
groups
benzyl group
group substituted
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JP2012503653A5 (cg-RX-API-DMAC7.html
JP2012503653A (ja
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ラマチャンドラ エス ホスマン
ラマチャンドラ エス ホスマン
ベニュ ラマン
ベニュ ラマン
ラジュ クマール
ラジュ クマール
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ザ ジョンズ ホプキンズ ユニヴァーシティー
ザ ジョンズ ホプキンズ ユニヴァーシティー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
JP2011529012A 2008-09-23 2009-09-23 縮合ジイミダゾジアゼピン化合物並びにその使用及び製造方法 Active JP5802872B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9932408P 2008-09-23 2008-09-23
US61/099,324 2008-09-23
PCT/US2009/005273 WO2010039187A2 (en) 2008-09-23 2009-09-23 Fused diimidazodiazepine compounds and methods of use and manufacture thereof

Publications (3)

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JP2012503653A JP2012503653A (ja) 2012-02-09
JP2012503653A5 JP2012503653A5 (cg-RX-API-DMAC7.html) 2015-04-30
JP5802872B2 true JP5802872B2 (ja) 2015-11-04

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JP2011529012A Active JP5802872B2 (ja) 2008-09-23 2009-09-23 縮合ジイミダゾジアゼピン化合物並びにその使用及び製造方法

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US (1) US8518901B2 (cg-RX-API-DMAC7.html)
EP (1) EP2350086B1 (cg-RX-API-DMAC7.html)
JP (1) JP5802872B2 (cg-RX-API-DMAC7.html)
AU (1) AU2009300357B2 (cg-RX-API-DMAC7.html)
CA (1) CA2738650C (cg-RX-API-DMAC7.html)
WO (1) WO2010039187A2 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012122471A2 (en) 2011-03-09 2012-09-13 The Johns Hopkins University Compounds and methods of use in ablative radiotherapy
US9322831B2 (en) 2008-09-23 2016-04-26 The Johns Hopkins University DDX3 as a biomarker for cancer and methods related thereto
CA2883577A1 (en) * 2012-09-04 2014-03-13 Niigata University Cancer diagnostic and therapeutic method targeting molecules expressed in cancer stem cells
WO2015200779A2 (en) * 2014-06-26 2015-12-30 The Johns Hopkins University Methods of prevention and treatment of viral disease by use of ddx3 inhibitors
CN115103844A (zh) * 2019-09-13 2022-09-23 原真股份有限公司 用于治疗例如自身免疫性疾病的作为lrrk2、nuak1和/或tyk2激酶调节剂的1,4-二氢苯并[d]吡唑并[3,4-f][1,3]二氮杂卓衍生物和相关化合物
DK4028017T3 (da) * 2019-09-13 2024-01-15 Origenis Gmbh 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepinderivater og beslægtede forbindelser som lrrk2-, nuak1- og/eller tyk2- kinasemodulatorer til behandling af for eksempel autoimmune sygdomme
US20230077636A1 (en) * 2021-08-31 2023-03-16 Natsar Pharmaceuticals, Inc. Intravenous formulations of rk-33

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
TW201311B (cg-RX-API-DMAC7.html) * 1991-06-17 1993-03-01 Hoffmann La Roche
EP1968581A4 (en) * 2005-12-16 2009-05-27 Genentech Inc TETRACYCLIC KINASE INHIBITORS

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Publication number Publication date
WO2010039187A3 (en) 2010-06-17
CA2738650A1 (en) 2010-04-08
CA2738650C (en) 2017-07-04
EP2350086A4 (en) 2012-06-27
US8518901B2 (en) 2013-08-27
EP2350086B1 (en) 2021-04-21
WO2010039187A2 (en) 2010-04-08
EP2350086A2 (en) 2011-08-03
US20110275588A1 (en) 2011-11-10
AU2009300357B2 (en) 2014-07-03
JP2012503653A (ja) 2012-02-09
AU2009300357A1 (en) 2010-04-08

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