JP5796333B2 - Microchip unit and compound synthesis apparatus using microchip unit - Google Patents

Microchip unit and compound synthesis apparatus using microchip unit Download PDF

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JP5796333B2
JP5796333B2 JP2011097846A JP2011097846A JP5796333B2 JP 5796333 B2 JP5796333 B2 JP 5796333B2 JP 2011097846 A JP2011097846 A JP 2011097846A JP 2011097846 A JP2011097846 A JP 2011097846A JP 5796333 B2 JP5796333 B2 JP 5796333B2
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microchip
flow path
reagent
holder
syringe pump
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JP2012229968A (en
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勝彦 大崎
勝彦 大崎
陽介 水川
陽介 水川
茂樹 山▲崎▼
茂樹 山▲崎▼
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Jfeエンジニアリング株式会社
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  The present invention relates to a microchip unit that performs chemical processing such as mixing, reaction, separation, and detection of chemical substances in a microchannel inside a substrate, and a compound synthesizer using the microchip unit, and in particular, PET (positron emission) tomography) relates to an apparatus for synthesizing a labeled compound used in a system (positron emission tomography).

  In the medical field, as one of methods for observing and diagnosing the internal state of a human body with images, in recent years, an image diagnostic method using a PET system using a substance that emits positrons has attracted attention. Image diagnostic methods using the PET system have been shown to be useful for cancer diagnosis or brain function diagnosis.

  As the radiopharmaceutical used in the PET system, FDG (2-fluoro-2-deoxyglucose), fluorine F-18 labeled compound labeled with fluorine F-18 such as FLT (3′-deoxy 3′-fluorothymidine), Examples thereof include carbon C-11 labeled compounds labeled with carbon C-11 such as methionine and laclopride. These labeled compounds are synthesized using a short-lived radioisotope (fluorine F-18, carbon C-11, etc.) produced using a cyclotron as a raw material using a synthesizer capable of automatic remote operation. In the initial synthesis apparatus, reaction vessels, valves, piping, and the like were fixed, and a washing operation was required for each batch synthesis operation. Such an apparatus cannot sterilize the wetted part and is difficult to clean completely, and thus a problem of cross contamination has been pointed out.

  The amount of radiopharmaceutical required in the PET system is negligible. For this reason, application of a microchemical system to the synthesis of such a labeled compound has been attempted. In the microchemical system, it has been proposed to perform the reaction operation in a minute reaction channel. When a chemical reaction is performed using a minute reaction channel, a minute microchannel is formed on the microchip, and a sample fluid is mixed in the microchannel to cause a chemical reaction. In this case, the microchip usually has a channel formed on a thin substrate having a thickness of several millimeters. Advantages include excellent heat removal, easy temperature control, and a small amount of sample fluid and reaction solvent. Further, if the synthesis process can be integrated on the microchip, advantages such as downsizing of the apparatus can be obtained.

  Synthetic examples using a microchip of a labeled compound for PET are disclosed in Patent Document 1, Patent Document 2, and Non-Patent Document 1. However, these synthesis examples are laboratory-level research results for synthesis validation and details of the synthesizer for actual clinical use are not mentioned. A synthesizer using microsynthesis is described in Non-Patent Document 2. However, these apparatuses require a washing operation of the flow path, and are not apparatuses that allow the flow paths of all the wetted parts to be disposable.

Japanese translation of PCT publication No. 2005-52027 JP-T-2006-527367

SCIENCE VOL310 16 DECEMBER 2005 NSTI-Nanotech 2007, www.nsti.org, ISBN 1-4200-6184-4 Vol.3,2007

  Thus, conventionally, a synthesizer capable of making all the liquid contact parts using a microchip disposable has not been realized. The present invention has been made to solve the above-described problems, and realizes a microchip unit that makes all the liquid contact parts disposable, and an apparatus for synthesizing a labeled compound using the microchip unit. The challenge is to make it easier. More specifically, a synthesis apparatus using a new microchip unit in the production of fluorine F-18 labeled compounds such as FDG (2-fluoro-2-deoxyglucose) and carbon C-11 labeled compounds such as methionine is provided. This is the issue.

In order to solve the above problems, one embodiment of the present invention includes a microchannel that performs chemical treatment of a fluid therein, a supply port for introducing a fluid into the microchannel on the surface, and the microstream A microchip having a discharge port for discharging the fluid discharged from the path, and a flow path coupled to the microchip and connected to at least one of the supply port and the discharge port of the microchip; The flow path is provided in the microchip holder having a first flow path connectable to a reagent container for storing a reagent and a second flow path connectable to a syringe pump, and the microchip holder. and a flow path switching mechanism for switching of the flow path, and the reagent container is attached to the microchip holder, mounted et the microchip holder Comprising said syringe pump operated by a reciprocating actuator, the said microchip, the microchip holder, said channel switching mechanism, a microchip unit the reagent container, and the syringe pump except the reciprocating actuator is disposable It is.

Another aspect of the invention, use a microchip unit described above, a gas supply mechanism for supplying a gas for transporting the fluid, and an exhaust gas recovery mechanism for recovering the gas, the Bei obtain microchip units It is a synthesis device of the compound.

  According to the present invention, the microchip holder is coupled to the microchip having the micro flow path, the supply port, and the discharge port, and the flow path and the flow path switching mechanism are provided in the micro chip holder. The road becomes disposable, and a disposable kit type synthesizer using a microchip unit can be provided.

1 is a schematic plan view of a synthesis device according to a first embodiment of the present invention. Outline side view of the synthesis apparatus of the first embodiment Operation diagram of the microchip holder functioning as a reagent supply station ((A-1) in the figure shows an operation diagram of the microchip holder having a reagent supply function, and (A-2) in the figure further has a dispensing function) (Operation diagram of the microchip holder is shown) Operational diagram showing another example of use of the channel switching mechanism of the microchip holder ((B) in the figure shows an example of opening and closing a single channel, and (C) in the figure shows the supply port and the discharge port of the microchip) (D) shows an example of switching two flow paths of the microchip holder) The schematic side view of the synthesizing | combining apparatus of 2nd embodiment of this invention. The top view which shows the F-18 label | marker microchip and microchip holder of Example 1 of this invention The top view which shows the C-11 labeling microchip and microchip holder of Example 2 of this invention

  Hereinafter, a microchip unit according to an embodiment of the present invention and a compound synthesis apparatus using the microchip unit will be described. However, the present invention can be embodied in various forms, and is not limited to the embodiments described in the present specification. This embodiment is provided with the intention of enabling those skilled in the art to fully understand the scope of the invention by fully disclosing the specification. Throughout the specification, the same components are denoted by the same reference numerals.

  FIG. 1 is a plan view of a synthesizing apparatus incorporating a microchip unit 10 according to the first embodiment of the present invention, and FIG. 2 is a side view of the synthesizing apparatus of FIG. The microchip unit 10 can be disposable and is attached to and detached from the synthesis apparatus. In FIG. 2, the microchip unit 10 removed from the synthesizer is shown by a two-dot chain line. In this embodiment, the microchip unit 10 includes a thin plate-like microchip 1 and a pair of microchip holders 2-1 and 2-2 coupled to both ends of the microchip 1 in the width direction.

  The microchip 1 is made of, for example, a glass, ceramics, silicon, or resin substrate. A minute microchannel is formed in the microchip 1 and a sample fluid is mixed in the microchannel to cause a chemical reaction. The microchip 1 is usually composed of a rectangular thin substrate having a thickness of several millimeters. A microchannel (not shown) is formed inside the substrate. A supply port 1a for introducing a reagent, a gas for transporting the reagent, or the like is formed on the surface of the substrate. Further, a discharge port 1b for discharging a synthesized compound, a reagent, a gas for transporting the reagent, or the like discharged from the microchannel is formed on the surface of the substrate.

  As shown in FIG. 2, the microchip 1 includes a substrate main body 1-1 in which grooves constituting the micro flow path are formed, and an external covering the substrate main body 1-1 and constituting the supply port 1a and the discharge port 1b. A thin plate-like lid body 1-2 in which a connection hole is formed. The width of the groove constituting the microchannel is not particularly limited, but is 10 to 1000 micrometers. This groove is formed by, for example, drilling, laser processing, etching, or the like. The substrate body 1-1 may be further divided into two in the thickness direction: a bottom plate in which grooves constituting the microchannel are formed, and an intermediate plate surrounding the microchannel in a frame shape.

  The microchip holders 2-1 and 2-2 coupled to the ends of the microchip 1 have a rectangular parallelepiped shape. The microchip holders 2-1 and 2-2 are formed with a fitting groove 2a into which the end of the microchip 1 is inserted. The width of the fitting groove 2 a of the microchip holders 2-1 and 2-2 is the same as the thickness of the microchip 1. When the end of the microchip 1 is inserted into the fitting groove 2a, the fitting groove 2a sandwiches the microchip 1 in the thickness direction. Thereby, the adhesiveness of the inner wall surface of the fitting groove 2a of the microchip holders 2-1 and 2-2 and the surface of the microchip 1 is enhanced. Since the adhesion between the inner wall surfaces of the microchip holders 2-1 and 2-2 and the surface of the microchip 1 is enhanced, the flow path of the microchip holders 2-1 and 2-2 and the supply port of the microchip 1 The sealing property between 1a or the discharge port 1b is also improved.

  The inlet-side microchip holder 2-1 functions as a reagent supply station. The microchip holder 2-1 is formed with a portion 2b for attaching the reagent container 8 for storing the reagent and a portion 2c for attaching the syringe pump 4. That is, in the microchip holder 2-1, a first flow path 2b that can be connected to the reagent container 8 is formed, and a second flow path 2c that can be connected to the syringe pump 4 is formed. A tube of a gas supply mechanism 5 for supplying a gas for transporting the reagent is connected to the reagent container 8. The syringe pump 4 is operated by a reciprocating actuator 4a.

  A tube of an exhaust gas recovery mechanism 6 that recovers a gas for supplying a reagent is connected to the microchip holder 2-2 on the outlet side. In the microchip holder 2-2, a third flow path 2d connected to the tube is formed. Since the microchip holder 2-2 also sandwiches the microchip 1 in the thickness direction, the sealing performance between the third flow path 2d and the discharge port 1b of the microchip 1 is improved.

  The microchip holders 2-1 and 2-2 have a feature that a flow path switching mechanism 9 (shaft body 9) is mounted in the middle of the flow paths 2b to 2d. In this embodiment, the flow path switching mechanism 9 is disposed on the left and right of the microchip 1.

  A cylindrical cavity 2e is formed in the middle of the flow paths 2b to 2d of the microchip holders 2-1 and 2-2. The hollow body 2e is inserted with a shaft body 9 such as a rotary cock constituting the flow path switching mechanism. The shaft body 9 is formed with a shaft body flow path 9a extending in the direction of the center line or extending in a direction perpendicular to the center line. By rotating the shaft body 9 around its center line, the flow paths 2b to 2d of the microchip holders 2-1 and 2-2 are switched. A specific method for switching the flow paths 2b to 2d will be described later.

  Instead of forming the shaft body channel 9 a having a closed cross section in the shaft body 9, a shaft body channel constituting groove having a cross section opened on the outer peripheral surface of the shaft body 9 may be formed. In this case, a shaft body flow path is formed between the shaft body flow path constituting groove of the shaft body 9 and the side surface of the cavity 2e of the microchip holders 2-1 and 2-2.

  The synthesizer includes the microchip unit 10, a rotary actuator 3 such as a motor, a syringe pump 4, a gas supply mechanism 5 that supplies a gas for conveying a reagent, an exhaust gas recovery mechanism 6 that recovers a gas, and a microchip 1. A heating / cooling mechanism 7 for heating and cooling is provided.

  The rotary actuator 3 is connected to one end of the shaft body 9 via a coupling 3a. The shaft body 9 rotates only around its center line, and does not move in the direction of the center line like a plunger pump. For this reason, the coupling between the rotary actuator 3 and the shaft body 9 can be easily performed, and the microchip 1 and the microchip holders 2-1 and 2-2 can be quickly replaced. By connecting to the rotary actuator, the shaft body can be automatically operated remotely.

  The syringe pump 4 dispenses reagents and supplies them to the microchip 1 by aspiration and discharge. The gas supply mechanism 5 supplies a gas such as nitrogen or helium to the microchip, and performs reagent transfer, flow path purge, and the like. The exhaust gas recovery mechanism 6 is connected to the exhaust gas recovery device of the facility and recovers the exhaust gas. A heating / cooling mechanism 7 is provided below the microchip 1 to heat / cool the reaction part of the microchip 1.

  FIG. 3A-1 shows an operation diagram of the flow path switching mechanism 9 of the microchip holder 2-1, which functions as a reagent supply station. The reagent supply operation to the microchip 1 is performed as follows, for example. First, as shown in FIG. 3 (A-1), the reagent container 8 and the syringe line are opened (that is, the first channel 2b and the second channel 2c are connected), and the reagent The reagent in the container 8 is aspirated by the syringe pump 4. In this case, the reagent is not sucked up to the syringe pump 4 in order to prevent the syringe pump 4 from coming into contact with the reagent. Thereafter, the shaft body 9 is rotated 180 degrees so that the second flow path 2c and the supply port 1a of the microchip 1 are connected. When the syringe pump 4 discharges the reagent, the reagent is supplied to the microchip 1. Even if the syringe pump 4 is not used, it is also possible to store the reagent quantified in advance in the reagent container 8 and supply it directly from the reagent container 8 to the microchip 1 by gas pressure or the like.

  FIG. 3A-2 shows an example in which a reagent dispensing function is further provided to the microchip holder 2-1, which functions as a reagent supply station. In the microchip holder 2-1, tube inlet / outlet channels 2 f and 2 g that can be connected to the loop-shaped reagent dispensing tube 31 are formed. The shaft body 9 is formed with a shaft body flow path 9b connected to the tube inlet / outlet flow paths 2f and 2g. The reagent container 8 and the syringe pump 4 are connected via a reagent dispensing tube 31. When the reagent in the reagent container 8 is aspirated by the syringe pump 4, the reagent in the reagent container 8 flows into the reagent dispensing tube 31. When the shaft body 9 is rotated 180 degrees and the syringe pump 4 discharges the reagent, the reagent is dispensed onto the microchip 1.

  FIG. 4 shows another example of use of the flow path switching mechanism 9. FIG. 4B shows the shaft body 9 incorporated in the microchip holder 2-2 on the outlet side. This shaft body 9 opens and closes the single third flow path 2d by rotating around its center line. From the state where the third channel 2d shown on the left side of FIG. 4B is closed, the shaft 9 is rotated 180 degrees to open the third channel 2d shown on the right side of FIG. Can be in a state. By opening the third flow path 2d, exhaust gas can be recovered.

  FIG. 4C shows still another usage example of the flow path switching mechanism 9. In this example, the state where the discharge port 1b of the microchip 1 and the discharge flow path 2h of the microchip holder 2-2 are connected and the state where the discharge port 1b of the microchip 1 and the supply port 1a are connected are switched. Yes. First, as shown on the left side of FIG. 4C, the discharge port 1b of the microchip 1 and the discharge flow path 2h of the microchip holder 2-2 are connected. When the shaft body 9 is rotated 180 degrees, the state is switched to a state where the discharge port 1b of the microchip 1 and the supply port 1a are connected.

  FIG. 4D shows still another usage example of the flow path switching mechanism 9. In this example, two discharge channels 2i and 2j are formed in the microchip holder 2-2, and the channel connected to the discharge port 1b of the microchip 1 is switched to the two discharge channels 2i and 2j. First, as shown on the left side of FIG. 4D, the discharge port 1b of the microchip 1 and the discharge channel 2j on the right side of the microchip holder 2-2 are connected. When the shaft body is rotated 180 degrees, the state is switched to a state in which the discharge port 1b of the microchip 1 and the left discharge path 2i are connected.

  As described above, by connecting the microchip holders 2-1 and 2-2 including the flow path switching mechanism 9 to the microchip 1, it is possible to realize a small kit for the flow paths of all the liquid contact parts. For this reason, the synthesis | combination of the compound using a disposable microchip unit is attained.

  FIG. 5 shows a compound synthesis apparatus according to the second embodiment of the present invention. In this embodiment, a supply port 1 a for supplying a reagent to the microchannel is formed on the top surface of the microchip 1, and a discharge port 1 b for discharging exhaust gas is formed on the bottom surface of the microchip 1. The microchip holder 2 is provided only at one end portion (the right end portion in FIG. 5) of the microchip 1, and the flow path switching mechanism 9 is disposed above and below the microchip 1. Since the configuration of the reagent container 8, the syringe pump 4, the rotary actuator 3, the gas supply mechanism 5, and the exhaust gas recovery mechanism 6 is the same as that of the synthesis apparatus of the first embodiment, the same reference numerals are given and description thereof is omitted. . The microchip holder 2 has a first flow path 2 b connected to the reagent container 8, a second flow path 2 c connected to the tube of the syringe pump 4, and a third connected to the tube of the exhaust gas recovery mechanism 6. Channel 2d is formed.

  An example is shown below and the synthesis operation of the labeled compound for PET using the microchip 11 and the microchip holder 12 will be described in more detail. Of course, the following examples do not limit the present invention to the operation of synthesizing a labeled compound for PET.

  FIG. 6 shows a flow of a fluorine F-18 labeling reaction using the microchip 11 and the microchip holder 12. The microchip 11 includes a reagent solution supply port 13, a discharge port 14, a resin filling unit 15, and a reaction unit 16. The microchip holder 12 includes dispensing reagent solution supply channel switching cocks 17-1 to 17-4, reagent solution supply channel switching cocks 18-1 to 18-2, and a channel for switching waste / objects. Switching cocks 19-1 to 19-2 are provided. Syringe pumps 20-1 to 20-4 are connected to the microchip holder 12.

  Using the microchip 11 and the microchip holder 12, a synthesis operation of FDG (2-fluoro-2-deoxyglucose) which is a fluorine F-18 labeled compound was performed.

  O-18 concentrated water containing fluorine F-18 ions collected from the target in a vial is pumped by nitrogen gas by switching the switching cock 18-1. At this time, fluorine F-18 ions are trapped in the resin filling portion 15. Next, the potassium carbonate / cryptofix solution as an eluent is sucked by the syringe pump 20-1, the switching cock 17-1 and the switching cock 19-1 are switched, and the trapped fluorine F-18 ions are converted into the syringe pump 20-. Elution by discharging 1 is conducted to the reaction section 16. The reaction part 16 is heated and the solvent is distilled off. Next, acetonitrile is sucked by the syringe pump 20-2, the switching cock 17-2 is switched, and the syringe pump 20-2 is discharged to supply the reaction part 16. Thereafter, the solvent is distilled off while the gas is flowing and evaporated to dryness. Next, the mannose triflate solution as a precursor is sucked by the syringe pump 20-3, the switching cock 17-3 is switched, and the syringe pump 20-3 is discharged to supply the reaction unit 16. Incubate at 100 ° C. for 3 minutes. Thereafter, the solvent is distilled off while the gas is flowing, and the mixture is concentrated. Next, the sodium hydroxide aqueous solution is sucked by the syringe pump 20-4, the switching cock 17-4 is switched, and the syringe pump 20-4 is discharged to supply the reaction section 16. Allow to react for 1.5 minutes at room temperature. Thereafter, the switching cocks 18-2 and 19-2 are switched and pumped with nitrogen gas to recover the fluorine F-18 labeled FDG solution.

  An example of the synthesis operation of the C-11 labeling reaction using the microchip 21 and the microchip holder 22 will be described below. FIG. 7 shows a flow of C-11 labeling reaction using the microchip 21 and the microchip holder 22. The microchip 21 includes a gas supply port 23, a discharge port 24, a resin filling unit 25, and a reaction unit 26. The microchip holder 12 is used to switch dispensing reagent solution supply channel switching cocks 27-1 to 27-4, reagent solution and gas supply channel switching cocks 28-2 to 28-2, and switching waste / objects. Flow path switching cocks 29-1 to 29-2 are provided. Syringe pumps 30-1 to 30-4 are connected to the microchip holder 22.

  Using the microchip 21 and the microchip holder 22, a synthesis operation of methionine, which is a carbon C-11 labeled compound, was performed. In advance, the lithium aluminum hydride solution as a reducing agent is sucked by the syringe pump 30-1, the switching cock 27-1 is switched, and the syringe pump 30-1 is discharged to the reaction section 26 cooled to -10 ° C. Lead. Further, the homocysteine thiolactone solution, which is a reaction precursor, is sucked by the syringe pump 30-3, the switching cock 27-3 is switched, and the syringe pump 30-3 is discharged to guide the resin filling portion 25.

  The switching cock 28-1 is switched, and carbon C-11 carbon dioxide obtained from the target is supplied to the reaction unit 26. At this time, carbon C-11 carbon dioxide is trapped in the lithium aluminum hydride solution in the reaction section 26. Next, the solvent is distilled off while flowing the gas, and it is evaporated to dryness. Next, the hydroiodic acid solution is sucked by the syringe pump 30-2, the switching cock 27-2 is switched, and the syringe pump 30-2 is discharged to supply the reaction section 26.

  The reaction section is heated to 100 ° C. At this time, the switching cocks 29-1 and 29-2 are switched, and the generated carbon C-11 methyl iodide is distilled, guided to the resin filling section 25, trapped at room temperature, and reacted with the precursor.

  Next, the acetic acid solution is sucked by the syringe pump 30-4, the switching cock 27-4 is switched, and the syringe pump 30-4 is discharged to supply the acetic acid solution to the resin filling unit 25. Thereafter, the switching cocks 28-2 and 29-2 are switched, and water is pumped with nitrogen gas to recover the carbon C-11 labeled methionine solution.

DESCRIPTION OF SYMBOLS 1 ... Microchip 1-1 ... Microchip board | substrate body 1-2 ... Microchip cover body 1a ... Supply port 1b ... Discharge port 2, 2-1, 2-2 ... Microchip holder 2a ... Fitting groove 2b ... 1st The second flow path 2d, the third flow path 2e, the hollow portions 2f, 2g, the tube input / output flow paths 2h, 2i, 2j, the discharge flow path 3, the rotary actuator 3a, the coupling 4, the syringe pump. 5 ... Gas supply mechanism 6 ... Exhaust gas recovery mechanism 7 ... Heating / cooling mechanism 8 ... Reagent container 9 ... Flow path switching mechanism (shaft body)
9a ... Shaft channel 9b ... Shaft channel 10 ... Microchip unit


Claims (9)

  1. It has a micro flow channel for performing chemical treatment of the fluid inside, and has a supply port for introducing the fluid into the micro flow channel on the surface and a discharge port for discharging the fluid discharged from the micro flow channel. Microchip,
    A first flow path coupled to the microchip and connected to at least one of the supply port and the discharge port of the microchip, the flow path being connectable to a reagent container for storing a reagent And a microchip holder having a second flow path connectable to a syringe pump ,
    A flow path switching mechanism provided in the microchip holder, for switching the flow path of the microchip holder;
    The reagent container attached to the microchip holder;
    The syringe pump attached to the microchip holder and actuated by a reciprocating actuator;
    Equipped with a,
    A microchip unit in which the syringe pump excluding the microchip, the microchip holder, the flow path switching mechanism, the reagent container, and the reciprocating actuator is disposable.
  2. The flow path switching mechanism is accommodated in a cylindrical cavity connected to the flow path of the microchip holder, and includes a shaft body in which a shaft body flow path or a shaft body flow path constituting groove is formed,
    2. The microchip unit according to claim 1, wherein the flow path of the microchip holder is switched by rotating the shaft body around a center line thereof.
  3. Before Kiryuro switching mechanism, the microchip state for connecting said second flow path and the first flow path to the reagent toward from the reagent container into the syringe pump can move, and from the syringe pump The microchip unit according to claim 1, wherein the microchip unit is switched to a state in which the second flow path and the supply port are connected so that a reagent can be supplied to the supply port.
  4. The flow path formed in the microchip holder further comprises a tube inlet / outlet flow path connectable to a reagent dispensing tube,
    The flow path switching mechanism connects the first flow path and the second flow path so that a reagent moving from the reagent container toward the syringe pump can be dispensed into the reagent dispensing tube. And the second flow path and the supply port are connected so that the reagent dispensed in the reagent dispensing tube can be supplied from the syringe pump to the supply port of the microchip. The microchip unit according to claim 3.
  5. The microchip includes a substrate body in which grooves constituting the microchannel are formed, and a lid body that covers the substrate body and has an external connection hole that forms at least one of the supply port and the discharge port. And comprising
    The microchip holder is formed with a fitting groove into which the end of the microchip is inserted, and the fitting groove of the microchip holder sandwiches the end of the microchip in the thickness direction. The microchip unit according to any one of claims 1 to 4.
  6. A microchip unit according to claim 1;
    A gas supply mechanism for supplying a gas for conveying a fluid;
    An exhaust gas recovery mechanism for recovering the gas, and a compound synthesis apparatus using a microchip unit.
  7. A microchip unit according to claim 2;
    A rotary actuator that rotates the shaft body of the flow path switching mechanism around its center line via a coupling;
    A gas supply mechanism for supplying a gas for conveying a fluid;
    An exhaust gas recovery mechanism for recovering the gas, and a compound synthesis apparatus using a microchip unit.
  8. A microchip unit according to claim 3;
    And the reciprocating actuator for operating the syringe pump for supplying a reagent to the microchannel of the microchip,
    A gas supply mechanism for supplying a gas for transporting the reagent;
    An exhaust gas recovery mechanism for recovering the gas, and a compound synthesis apparatus using a microchip unit.
  9.   9. The compound synthesizer using a microchip unit according to claim 6, wherein the synthesizer synthesizes a labeling compound for PET (positron emission tomography).
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