JP5771437B2 - Living body electrode - Google Patents

Description

  The present invention relates to an electrode for living body typified by an epidural electrode, and is particularly suitable as an epidural electrode to be inserted into the skull of an animal.

As a method for acquiring information in the brain, it is known to place information on the scalp and measure information in the brain. That is, there is a method of measuring an intracerebral signal in the skull via a skull, skin, or the like. However, when passing through the skull, skin, etc., weak intracranial signals attenuated, resulting in low spatial resolution, making accurate measurement difficult.
Therefore, conventionally, craniotomy was performed, epidural electrodes were placed directly on the brain, and signals within the brain that were weak were measured to improve spatial resolution and reduce signal attenuation (Patent Literature). 1).

  Generally, the epidural electrode has a plurality of electrodes such as platinum fixed on one side of an electrode sheet formed of silicone or the like. With these epidural electrodes, it is possible to directly measure intracranial signals in the skull, test brain functions by electrically stimulating the brain, and treat intractable pain and involuntary movements It is said that. Therefore, experiments using such epidural electrodes are attracting attention in the medical field.

JP 2007-181523 A

  Since the above-described epidural electrode uses a relatively hard substrate such as silicone, it is necessary to accurately match the shape of the brain using a CT scan or the like. However, for example, in the case of small rodent animals such as experimental mice, the brain itself is small, so it is necessary to produce electrodes strictly in accordance with the shape of the brain, and it is also necessary to simultaneously reduce the electrode area. In addition, the head is opened, and electrodes are placed directly on the brain, which is invasive. That is, in order to measure healthy animals, it is necessary to make the craniotomy area as small as possible.

  Accordingly, the present invention has been made to solve the above problems, and provides a living body mounting electrode that can be installed even in a small space such as in the skull of a small animal such as a rodent and is not affected by the shape of the brain. It is.

In order to solve the above-described problem, the derived invention according to claim 1 is a living body mounting electrode that is installed at least in part in the cranium, and receives and / or receives a weak electric signal flowing in the cranium. The electrode unit includes an electrode unit that transmits a weak electrical signal in the cranium, a connector unit that can be electrically connected to an external device, and a transmission unit that electrically connects the electrode unit and the connector unit. Has electrode wiring connected to each electrode terminal, and the electrode wiring connected to the electrode terminal arranged on the tip side of the electrode portion has a width of the rear row. Passing between the electrode terminals adjacent in the direction, the electrode portion has flexibility, the electrode wiring is disposed on the flexible substrate, and the surface of the substrate and The electrode arranged on the back surface The child is provided with electrode terminal layers on the front and back sides of the substrate, the electrode terminal layer on the front surface side of the substrate and the electrode terminal layer on the back surface side of the substrate are formed in communication, and the surface on the back surface side of the electrode terminal is an insulating layer It is the electrode for biological mounting | wearing characterized by being covered with .
That is, according to the first aspect of the present invention, at least a part of the living body mounting electrode installed in the skull receives a weak electric signal flowing in the skull and / or transmits a weak electric signal in the skull. An electrode portion to be electrically connected, a connector portion that can be electrically connected to an external device, and a transmission portion that electrically connects the electrode portion to the connector portion. There is an electrode wiring that is distributed with spread and connected to each electrode terminal, and the electrode wiring connected to the electrode terminal arranged on the tip side of the electrode section is between the electrode terminals adjacent in the width direction of the rear row. It passes, and the electrode part has flexibility.

  As used herein, “distributed with a planar spread” includes one in which two electrode terminals are arranged.

  According to such a configuration, since the electrode wiring connected to the electrode terminal arranged on the front end side of the electrode portion passes between the electrode terminals adjacent in the width direction of the rear row, in the electrode insertion direction. On the other hand, the space for electrode wiring can be omitted. Since the electrode portion is flexible and can be bent or bent, it can be installed in accordance with the shape of the brain and does not require a strict design.

  The invention according to claim 2 is the living body mounting electrode according to claim 1, wherein the electrode wiring is arranged closer to the transmission part than the electrode terminal arranged on the tip side of the electrode part. .

  According to such a configuration, since the electrode wiring is arranged closer to the transmission part than the electrode terminal arranged on the distal end side of the electrode part, even if it contacts the skull, it is difficult to disconnect. Further, since no electrode wiring is arranged at the distal end in the insertion direction, no extra space is created at the distal end in the insertion direction.

The invention of claim 1 described above, the electrode wiring is disposed over a flexible substrate, and, you characterized in that arranged on the front and back surfaces of the substrate.

According to this configuration, since the electrode wiring is arranged on the flexible substrate, the electrode can be positioned in the brain by bending the substrate. Moreover, since it is distribute | arranged on the surface and back surface of a board | substrate, the space required for installing electrode wiring can be abbreviate | omitted.
In the invention according to claim 3, the electrode wiring is provided on both surfaces of the substrate, and one electrode wiring on the front surface side of the substrate and one electrode wiring on the back surface side of the substrate overlap in the thickness direction. The living body mounting electrode according to claim 1, wherein one electrode wiring on the front surface side of the substrate is connected to an electrode terminal different from the one electrode wiring on the back surface side of the substrate. It is.

  The invention according to claim 4 is the living body mounting electrode according to any one of claims 1 to 3, wherein the electrode terminal is circular.

  According to such a configuration, since the electrode terminal is circular, the area is easily defined and analysis is easy.

  The invention according to claim 5 is the living body mounting electrode according to any one of claims 1 to 4, wherein an insulating layer is provided on an upper surface of the electrode wiring.

  According to such a configuration, noise is difficult to detect because the insulating layer is provided on the upper surface of the electrode wiring.

  According to the present invention, since the electrode wiring connected to the electrode terminal arranged on the tip side of the electrode portion passes between the electrode terminals adjacent in the width direction of the rear row, On the other hand, the space for electrode wiring can be omitted. Since the electrode portion is flexible and can be bent or bent, it can be installed in accordance with the shape of the brain and does not require a strict design.

It is explanatory drawing which shows the epidural electrode which concerns on 1st Embodiment of this invention. It is an enlarged view which shows the electrode area | region of FIG. It is a partially broken perspective view which shows the electrode area | region of FIG. It is the partial cross section exploded perspective view which expressed typically the layer composition of the electrode field. It is a partially broken perspective view which shows the connector area | region of FIG. It is the partial cross-section exploded perspective view which expressed typically the layer composition of the transmission field. It is an enlarged view which shows the epidural electrode of FIG. It is explanatory drawing which shows the epidural electrode which concerns on 2nd Embodiment of this invention. It is explanatory drawing which shows the epidural electrode which concerns on 3rd Embodiment of this invention. It is explanatory drawing which shows the epidural electrode which concerns on 4th Embodiment of this invention.

Hereinafter, embodiments of the present invention will be described in detail.
The living body mounting electrode of the present embodiment is specifically an epidural electrode 1 which is bent and inserted into the skull of an animal such as a rat. When viewed from above, the epidural electrode 1 has a dumbbell shape as shown in FIG. That is, the area of both end portions is large and the intermediate portion is thin. The epidural electrode 1 includes an electrode region 20 that includes an electrode terminal 10 that receives a weak electric signal flowing in the skull and / or transmits a weak electric signal in the skull, and the weak electric signal. A transmission region 21 having an electrode wiring 12 for transmitting the signal to the outside of the cranium, and a connector region 22 having a connection terminal 11 that can be electrically connected to an external device (not shown).

For convenience of explanation, the entire layer configuration of the epidural electrode 1 will be described prior to the characteristic configuration of the epidural electrode 1 of the present embodiment.
In the following description, a measurement surface (front surface) that actually contacts a brain or nerve and measures a weak current is distinguished from a protective surface (back surface) that does not contribute to the measurement. The measurement surface and the protective surface have the same basic laminated structure, but are slightly different in shape and arrangement. In the drawing, the electrode wiring 12a positioned on the front surface side of the substrate 2 is represented by a solid line, and the electrode wiring 12b positioned on the back surface side of the substrate 2 is represented by a broken line.

The layer configuration of the epidural electrode 1 of the present invention is substantially the same in any region. The epidural electrode 1 has a flexible substrate 2 at the center, and electrode wiring layers 3 are provided on both sides thereof as shown in FIGS. And the electrode wiring layer 3 or the connection terminal layer 7 is laminated | stacked, and the insulating layer 5 is provided in the outer side.
For convenience, the surface side (upper side in the drawing) of the electrode wiring layer 3 as shown in FIG. 4 is referred to as an electrode wiring layer 3a, and the back side (lower side in the drawing) is referred to as an electrode wiring layer 3b. Similarly, the front side is referred to as electrode terminal layer 6a, connect terminal layer 7a, insulating layer 5a, and the back side is referred to as electrode terminal layer 6b, connect terminal layer 7b, and insulating layer 5b.
The electrode wiring layer 3a on the front side is constituted by a line group and is distributed on one surface of the substrate 2, and connects about half of the electrode terminal layers 6a and about half of the connect terminal layers 7a. Further, the back side electrode wiring layer 3b is composed of a line group and distributed on the other side of the substrate 2, and connects the remaining half of the electrode terminal layers 6b and the remaining half of the connection terminal layers 7b. ing.

  Hereinafter, each part structure is demonstrated.

The substrate 2 is made of a flexible and flexible material such as polyimide resin, parylene resin, or silicone resin. The thickness of the substrate 2 is preferably 5 μm to 100 μm, and particularly preferably 12 μm to 50 μm.
The substrate 2 can be bent freely in all three regions of the electrode region 20, the transmission region 21, and the connector region 22.

The electrode wiring layer 3 is a layer formed of a metal whose main material is a high conductivity substance such as gold, silver, platinum, or copper. Here, the “main material” represents a state occupying 95% or more of the contained components.
The thickness of the electrode wiring layer 3 is preferably 5 μm to 30 μm. More preferably, it is 10 μm to 25 μm, and particularly preferably 15 μm to 20 μm.
In principle, the electrode wiring layer 3a on the measurement surface (front surface) is provided at a position corresponding to each other with the electrode wiring layer 3b on the protection surface (back surface) and the substrate 2 interposed therebetween as shown in FIG. That is, in principle, the electrode wiring layer 3b exists above the electrode wiring layer 3a.

The insulating layers 5a and 5b are thin film layers called coverlays among those skilled in the art such as Kapton and do not pass current. The insulating layers 5 a and 5 b can be bent in accordance with the bending of the substrate 2.
As shown in FIGS. 3 to 5, the insulating layer 5 is provided on the measurement surface (surface) so as to cover the electrode wiring layer 3 and the substrate 2 while avoiding the electrode terminal layer 6 a and the connect terminal layer 7. The protective surface (back surface) covers the electrode wiring layer 3 a, the electrode terminal layer 6 a, the connect terminal layer 7 a, and the exposed surface of the substrate 2. That is, on the measurement surface, the electrode terminal layer 6a is exposed, and the electrode terminal 10 is not covered with the insulating layer 5. On the other hand, the protective surface covers the insulating layer 5 over the entire surface. Therefore, it is possible to prevent noise from the protective surface side from being applied to the electric signal.
The thickness of the insulating layer 5 is preferably 5 μm to 30 μm. More preferably, it is 7.5 μm to 20 μm. A thickness of 10 μm to 15 μm is particularly preferable.

The electrode terminal 10 is made of a material having high conductivity. For example, the main material is gold, platinum, copper, or the like. In particular, from the viewpoint of biocompatibility, it is preferable to use gold as the main material.
The thickness of the electrode terminal 10 is preferably 10 μm to 60 μm. More preferably, it is 20 μm to 50 μm. A thickness of 30 to 40 μm is particularly preferable.
In the present embodiment, the electrode terminal 10 is formed by providing electrode terminal layers 6 a and 6 b on the front and back of the substrate 2 and bonding them together. That is, the electrode terminal layer 6a on the measurement surface is provided at a position corresponding to each other across the substrate 2 and the electrode terminal layer 6b on the protection surface as shown in FIGS. That is, the electrode terminal layer 6b exists above the electrode terminal layer 6a.
The electrode terminal layer 6a on the measurement surface and the electrode terminal layer 6b on the protection surface are partially in communication. In the present embodiment, communication is made along the through hole 15.

The connection terminal layer 7 is a layer formed of a metal whose main material is high conductivity, such as gold, silver, platinum, and copper. The thickness of the connection terminal layer 7 is preferably 5 μm to 50 μm. More preferably, the thickness is 10 μm to 30 μm. It is particularly preferable that the thickness is 15 μm to 20 μm.
As shown in FIG. 5, the connection terminal layer 7a on the measurement surface is provided at a position corresponding to each other with the connection terminal layer 7b on the protection surface and the substrate 2 interposed therebetween. That is, the connect terminal layer 7b exists above the connect terminal layer 7a.

  The electrode wiring layers 3a and 3b, the electrode terminal layers 6a and 6b, and the connection terminal layers 7a and 7b are formed by a known method such as a printing method, a vacuum deposition method, or a sputtering method.

  Subsequently, the configuration of the epidural electrode 1 of the present embodiment will be described separately for each region.

First, the electrode region 20 will be described.
The electrode region 20 has a substantially rectangular outer shape, and has a plurality of electrode terminals 10 and a plurality of electrode wirings 12 as shown in FIGS. The electrode wiring 12 connects the electrode terminal 10 and the connection terminal 11 in the connector region 22 and is a portion where the above-described electrode wiring layer 3 is laminated.
The length of the electrode region 20 in the width direction decreases from the proximal end (transmission region 21 side) to the distal end as shown in FIGS. And the external shape of the electrode area | region 20 is carrying out the shape along the outer peripheral surface of the electrode terminal 10 located outside.
The electrode terminal 10 is a portion in which the above-described electrode terminal layers 6a and 6b are laminated, and is formed by connecting the electrode terminal layers 6a and 6b on the front surface and the back surface. That is, the surface of the electrode terminal 10 on the measurement surface is exposed from the insulating layer 5, and the surface of the electrode terminal 10 on the protective surface is covered with the insulating layer 5.
The electrode terminal 10 has a circular shape, and a through hole 15 penetrating from the measurement surface to the protection surface is provided at the center thereof. The diameter of the electrode terminal 10 is smaller than the diameter of the connection terminal 11. Specifically, the diameter of the electrode terminal 10 is preferably 10 μm to 600 μm, and more preferably 30 μm to 300 μm. A thickness of 50 μm to 100 μm is particularly preferable. The through-hole 15 can be inserted with a portion of a deep brain layer electrode (not shown) that can be inserted into the deep brain portion. The inner diameter of the through hole 15 is preferably 5 μm to 300 μm, and more preferably 20 μm to 200 μm. A thickness of 50 μm to 100 μm is particularly preferable.

A plurality of electrode terminals 10 are provided in the electrode region 20 and distributed with a planar spread. In the present embodiment, the electrode terminals 10 are arranged in parallel from the tip of the electrode region 20 toward the transmission region 21 as shown in FIG. The adjacent electrode terminals 10 are arranged at equal intervals with a predetermined interval. The distance L between the centers of the electrode terminals 10 adjacent in the column direction is longer than the length l in the width direction (left and right) of the electrode wiring 12 as shown in FIG. That is, the electrode wiring 12 can be laid between the adjacent electrode terminals 10. In the present embodiment, the distance between the centers of the adjacent electrode terminals 10 is equal in both the row direction and the column direction. That is, all the electrode terminals 10 are arranged at equal intervals.
The distance L between the centers of the adjacent electrode terminals 10 is not particularly limited as long as it is not less than the length l in the width direction of the electrode wiring 12, but for example, 0.1 mm is used when measuring small animals such as rodents. To 10 mm, and more preferably 0.2 mm to 5 mm. Particularly preferred is 0.5 mm to 1.5 mm.

  The number of electrode terminals 10 is equal to the number of connect terminals 11 as shown in FIG. The number of rows of electrode terminals 10 is equal to or greater than the number of rows of connect terminals 11. Further, the number of electrode terminals 10 decreases from the distal end (upper) of the electrode region 20 toward the proximal end (lower) of the electrode region 20. Specifically, the electrode terminals 10 are arranged in three rows at equal intervals, the front electrode electrode 10 is three, the second electrode terminal 10 is four, the third electrode terminal 10 is Five are arranged. That is, the number of electrode terminals 10 decreases in the order of 5, 4, 3 from the base end to the tip end.

  When any one of the electrode terminals 10 is used as a reference electrode, it is preferable to use the electrode terminal 10 located outside the electrode region 20. In other words, it is preferable to use one of the electrode terminals 10 positioned at the end of the electrode region 20 as the reference electrode. The “end” here means the vicinity of the outline.

Here, the positional relationship between the electrode terminal 10 and the electrode wiring 12 in the electrode region 20 will be described mainly with reference to FIGS.
The electrode wiring 12 is provided across the electrode terminals 10. As shown in FIG. 2, there is no electrode wiring 12 on the distal end side of the electrode terminal 10 located at the most distal end (upward) in the row direction in the electrode terminal 10. That is, the electrode wiring 12 does not exist at the tip end side of the electrode region 20, and only the substrate 2 and the insulating layer 5 exist at that portion as shown in FIGS.
The electrode wiring 12 connected to the electrode terminal 10 located at the forefront of the electrode region 20 is located in a subsequent row and passes between the electrode terminals 10 adjacent in the width direction. Specifically, the electrode wiring 12 passes through the midpoint between the electrode terminals 10 adjacent in the column direction of the subsequent row. Any one of the electrode terminals 10 located in the front row is connected to the electrode wiring 12a on the measurement surface, and any one of the electrode terminals 10 located in the front row is connected to the electrode wiring 12b on the protection surface. Has been.
Further, the electrode wiring 12 is provided over three regions of the electrode region 20, the transmission region 21, and the connector region 22 as shown in FIG. 1. An electrode terminal 10 is connected to one end of the electrode wiring 12, and a connect terminal 11 is connected to the other end. The electrode terminal 10 and the electrode wiring 12 are welded together. The connection terminal 11 and the electrode wiring 12 are welded together.
The number of electrode wirings 12a on the measurement surface of the substrate 2 is equal to the number of electrode wirings 12b on the protective surface of the substrate 2.
Then, the electrode wiring layer 3a on the measurement surface side and the electrode wiring 3b on the measurement surface side overlap in the thickness direction in the vicinity of the end portion on the transmission region 21 side as shown in FIG. That is, as shown in FIG. 2, the electrode wiring 12a on the measurement surface side and the electrode wiring 12b on the protection surface side that are bent in most of the electrode region 20 overlap on the same projection surface in the vicinity of the end portion on the transmission region 21 side. Yes.

Next, the transmission area 21 will be described.
The transmission region 21 has a substantially rectangular shape whose long side is directed in the longitudinal direction, and has a long shape. A plurality of electrode wirings 12 are arranged in the transmission region 21 as shown in FIG. 1, and the electrode wirings 12 face the longitudinal direction. The respective electrode wirings 12 are arranged parallel to each other in the longitudinal direction as shown in FIG. 6, and are located at equal intervals. The number of electrode wirings 12 is equal to the number of electrode terminals 10. Further, the number of electrode wirings 12a on the measurement surface is equal to the number of electrode wirings 12b on the protective surface. The distance between the electrode wirings 12 is not particularly limited, but is preferably 1 μm to 1 mm, more preferably 5 μm to 0.5 mm, and more preferably 0.01 mm in order to make the transmission region 21 flexible and flexible. To 0.2 mm is particularly preferred. Since the transmission region 21 is flexibly flexible, the electrode wiring 12 can be easily routed, and a plurality of electrodes can be placed in the brain by making a small hole in the skull.

  The electrode wiring layer 3a on the measurement surface side and the electrode wiring 3b on the protection surface side overlap in the thickness direction in the entire transmission region 21 as shown in FIG. The electrode wiring 12a on the measurement surface side and the electrode wiring 12b on the protection surface side overlap the entire projection area 21 on the same projection surface.

Subsequently, the connector region 22 will be described.
The connector region 22 has a substantially rectangular shape with the long side facing the width direction. The connector region 22 extends in the width direction from the transmission region 21 side to the rear of the connector region 22.
In the connector region 22, a plurality of connect terminals 11 are arranged as shown in FIG. The connection terminal 11 is a portion where the connection terminal layer 7 is laminated. Adjacent connection terminals 11 are arranged at equal intervals. The connection terminals 11 are arranged in parallel in the row direction, and are also arranged in parallel in the column direction.
The number of connection terminals 11 is equal to the number of electrode terminals 10 in the electrode region 20. Specifically, the connect terminals 11 are arranged in 2 rows and 5 columns, and each is connected to the electrode wiring 12. In addition, the connection terminal 11 is provided with a connection hole 16 that can be connected to a terminal of an external device in the center, and can be connected to an external device (not shown). Further, the board area occupying the connector region 22 is larger than the board area occupying the electrode region 20.

Here, the positional relationship between the connection terminal 11 and the electrode wiring 12 in the connector region 22 will be described mainly with reference to FIGS.
The connector region 22 has substantially the same configuration as the electrode region 20.
That is, the electrode wiring 12 is provided across the connection terminals 11. There is no electrode wiring 12 on the rear end side of the connection terminal 11 in the last row. The electrode wiring 12 is bent along the shape of the connection terminal 11. The electrode wiring 12 passes through a midpoint between the connection terminals 11 adjacent in the column direction. The electrode wiring 12 is arranged on both the front surface and the back surface of at least one of the group of connection terminals 11 in the column direction.
Then, the connection terminal 11 on the measurement surface side and the connection terminal 11 on the measurement surface side overlap with each other in the thickness direction in the vicinity of the end portion on the transmission region 21 side, like the electrode terminal 10 in the electrode region 20. That is, in most of the connector region 22, the bent electrode wiring 12a on the measurement surface side and the electrode wiring 12b on the protection surface side overlap on the same projection surface in the vicinity of the end portion on the transmission region 21 side.

  If the epidural electrode 1 of this embodiment is used, the electrode wiring 12 connected to the electrode terminal 10 arranged on the front end side of the electrode region 20 is between the electrode terminals 10 adjacent in the width direction of the rear row. Since it passes, the space of the electrode wiring 12 can be omitted with respect to the insertion direction of the electrode. Since the electrode region 20 can be bent, it can be bent in accordance with the shape of the brain, and a strict design is not required. Further, since the electrode terminal 10 has a through hole 15 into which a part of the deep brain electrode can be inserted, by measuring the electrode terminal 10 and the deep brain electrode in combination, both the brain surface and the deep brain region can be measured. It can be measured simultaneously.

  In the above-described embodiment, twelve electrode terminals 10 are used. However, the present invention is not limited to this, and is not limited to the number of rows, the number of columns, or the number. For example, as shown in FIG. 8, from the tip (upper) of the electrode region 20 toward the base end (lower) of the electrode region 20, there are three, four, five, six, etc., compared to the first embodiment The number of lines may be increased (second embodiment).

  In the above-described embodiment, the electrode wiring layer 3 or the electrode terminal layer 6 or the connect terminal layer 7 is laminated on both surfaces of the substrate 2, but the present invention is not limited to this, and the substrate 2 as shown in FIG. You may laminate | stack only on one side (3rd Embodiment).

  In the above-described embodiment, the electrode terminals 10 are evenly distributed on the front surface of the electrode region 20, but the present invention is not limited to this, and the brain is approximately at the center of the electrode region 20 as shown in FIG. You may provide the insertion hole 100 which can insert a deep part electrode intensively (4th Embodiment).

  In the above-described embodiment, the electrode wiring layer 3 is provided at a corresponding position with the substrate 2 interposed therebetween, but the present invention is not limited to this, and the electrode wiring layer 3 may be shifted in the width direction. By shifting, disconnection of the electrode wiring can be prevented.

  In the above-described embodiment, the through hole 15 is provided in the center of the electrode terminal 10, but the present invention is not limited to this, and the through hole 15 may not be provided.

  Further, a plurality of electrode wiring layers 3, electrode terminal layers 6, or connect terminal layers 7 may be laminated. That is, the insulating layer 5 may be laminated after the electrode wiring layer 3 or the electrode terminal layer 6 or the connect terminal layer 7 is laminated.

  In the above-described embodiment, the epidural electrode has been described as a specific example of the living body mounting electrode. However, the present invention is not limited to this, and any electrode may be used as long as at least a part thereof is placed in the skull. For example, a subdural electrode may be used.

DESCRIPTION OF SYMBOLS 1 Epidural outer electrode 2 Board | substrate 5 Insulating layer 10 Electrode terminal 12 Electrode wiring 20 Electrode area | region (electrode part)
21 Transmission area (transmission part)
22 Connector area (connector part)

Claims (5)

In the electrode for living body mounting in which at least a part is installed in the skull,
An electrode for receiving a weak electric signal flowing in the skull and / or transmitting a weak electric signal in the skull;
A connector that can be electrically connected to an external device;
A transmission part for electrically connecting the electrode part and the connector part;
In the electrode portion, there are electrode wirings in which a plurality of electrode terminals are distributed with a planar spread and connected to each electrode terminal,
The electrode wiring connected to the electrode terminal arranged on the tip side of the electrode part passes between the electrode terminals adjacent in the width direction of the rear row,
The electrode part has flexibility ,
The electrode wiring is disposed on a flexible substrate, and is disposed on the front surface and the back surface of the substrate,
The electrode terminal is provided with an electrode terminal layer on the front and back of the substrate, the electrode terminal layer on the front surface side of the substrate and the electrode terminal layer on the back surface side of the substrate are formed in communication with each other,
An electrode for living body mounting, wherein the back surface of the electrode terminal is covered with an insulating layer .   The living body mounting electrode according to claim 1, wherein an electrode wiring is arranged closer to the transmitting portion than an electrode terminal arranged on the distal end side of the electrode portion. The electrode wiring is provided on both sides of the substrate,
One electrode wiring on the front side of the substrate and one electrode wiring on the back side of the substrate overlap in the thickness direction,
The living body mounting electrode according to claim 1 , wherein one electrode wiring on the front surface side of the substrate is connected to an electrode terminal different from one electrode wiring on the back surface side of the substrate .   The living body mounting electrode according to any one of claims 1 to 3, wherein the electrode terminal is circular.   The living body mounting electrode according to any one of claims 1 to 4, wherein an insulating layer is provided on an upper surface of the electrode wiring.

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