JP5764072B2 - 改変非細胞毒性プロテアーゼ - Google Patents
改変非細胞毒性プロテアーゼ Download PDFInfo
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- JP5764072B2 JP5764072B2 JP2011550638A JP2011550638A JP5764072B2 JP 5764072 B2 JP5764072 B2 JP 5764072B2 JP 2011550638 A JP2011550638 A JP 2011550638A JP 2011550638 A JP2011550638 A JP 2011550638A JP 5764072 B2 JP5764072 B2 JP 5764072B2
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- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Neurology (AREA)
- General Engineering & Computer Science (AREA)
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- Molecular Biology (AREA)
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- Gastroenterology & Hepatology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0903006.5 | 2009-02-23 | ||
| GBGB0903006.5A GB0903006D0 (en) | 2009-02-23 | 2009-02-23 | Modified non-cytotoxic proteases |
| PCT/GB2009/002892 WO2010094905A1 (en) | 2009-02-23 | 2009-12-16 | Modified non-cytotoxic proteases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518403A JP2012518403A (ja) | 2012-08-16 |
| JP2012518403A5 JP2012518403A5 (enExample) | 2013-02-14 |
| JP5764072B2 true JP5764072B2 (ja) | 2015-08-12 |
Family
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|---|---|---|---|
| JP2011550638A Expired - Fee Related JP5764072B2 (ja) | 2009-02-23 | 2009-12-16 | 改変非細胞毒性プロテアーゼ |
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| EP (1) | EP2398495B2 (enExample) |
| JP (1) | JP5764072B2 (enExample) |
| AU (1) | AU2009340404B2 (enExample) |
| CA (1) | CA2753101C (enExample) |
| ES (1) | ES2537338T5 (enExample) |
| GB (1) | GB0903006D0 (enExample) |
| WO (1) | WO2010094905A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9617671D0 (en) * | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
| US8012491B2 (en) * | 1996-08-23 | 2011-09-06 | Syntaxin, Ltd. | Recombinant toxin fragments |
| AU2015261716B2 (en) * | 2010-05-20 | 2018-01-04 | Allergan, Inc. | Degradable clostridial toxins |
| BR112012029666A2 (pt) | 2010-05-20 | 2020-10-06 | Allergan, Inc. | toxinas clostridiais degradáveis |
| EP3202903B1 (en) | 2010-12-22 | 2020-02-12 | President and Fellows of Harvard College | Continuous directed evolution |
| GB201108108D0 (en) | 2011-05-16 | 2011-06-29 | Syntaxin Ltd | Therapeutic fusion proteins |
| WO2013017522A1 (en) * | 2011-08-04 | 2013-02-07 | Merz Pharma Gmbh & Co. Kgaa | Alteration of proteolytic cleavage of botulinum neurotoxins |
| GB201219602D0 (en) * | 2012-10-31 | 2012-12-12 | Syntaxin Ltd | Recombinant clostridium botulinum neurotoxins |
| WO2014117148A1 (en) | 2013-01-28 | 2014-07-31 | New York University | Treatment methods using atoxic neurotoxin derivatives |
| GB201312295D0 (en) * | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Suppression of itch |
| GB201312317D0 (en) | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Cationic neurotoxins |
| EP3097196B1 (en) | 2014-01-20 | 2019-09-11 | President and Fellows of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| US10920208B2 (en) | 2014-10-22 | 2021-02-16 | President And Fellows Of Harvard College | Evolution of proteases |
| WO2016110662A1 (en) | 2015-01-09 | 2016-07-14 | Ipsen Bioinnovation Limited | Cationic neurotoxins |
| US11299729B2 (en) | 2015-04-17 | 2022-04-12 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| US10392674B2 (en) | 2015-07-22 | 2019-08-27 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
| US11524983B2 (en) | 2015-07-23 | 2022-12-13 | President And Fellows Of Harvard College | Evolution of Bt toxins |
| US10612011B2 (en) | 2015-07-30 | 2020-04-07 | President And Fellows Of Harvard College | Evolution of TALENs |
| GB201517450D0 (en) | 2015-10-02 | 2015-11-18 | Ipsen Biopharm Ltd | Method |
| WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| GB201607901D0 (en) * | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
| EP3263710A1 (en) | 2016-07-01 | 2018-01-03 | Ipsen Biopharm Limited | Production of activated clostridial neurotoxins |
| JP2020519267A (ja) * | 2017-05-12 | 2020-07-02 | セレクティスＣｅｌｌｅｃｔｉｓ | より安全な細胞免疫療法のためのプロテアーゼベースの切り替えキメラ抗原受容体 |
| US11447809B2 (en) | 2017-07-06 | 2022-09-20 | President And Fellows Of Harvard College | Evolution of tRNA synthetases |
| US12060553B2 (en) | 2017-08-25 | 2024-08-13 | President And Fellows Of Harvard College | Evolution of BoNT peptidases |
| US11624130B2 (en) | 2017-09-18 | 2023-04-11 | President And Fellows Of Harvard College | Continuous evolution for stabilized proteins |
| BR112020006827A2 (pt) | 2018-01-29 | 2020-10-06 | Ipsen Biopharm Limited | neurotoxinas botulínicas clivando snare não neuronal |
| US11913044B2 (en) | 2018-06-14 | 2024-02-27 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
| GB201815844D0 (en) | 2018-09-28 | 2018-11-14 | Ipsen Biopharm Ltd | Therapeutic & comestic uses of botulinum neurotoxin serotype e |
| GB201815817D0 (en) | 2018-09-28 | 2018-11-14 | Ispen Biopharm Ltd | Clostridial neurotoxins comprising and exogenous activation loop |
| KR102174197B1 (ko) | 2019-06-12 | 2020-11-04 | 주식회사 앤씨비아이티 | 생산성이 향상된 비독성 프로테아제 |
| US12655182B2 (en) | 2019-07-15 | 2026-06-16 | President And Fellows Of Harvard College | Evolved botulinum neurotoxins and uses thereof |
| WO2022133266A1 (en) * | 2020-12-18 | 2022-06-23 | The Broad Institute, Inc. | Evolution of botulinum neurotoxin proteases |
| CN114957482B (zh) * | 2021-02-26 | 2024-09-24 | 重庆誉颜制药有限公司 | 一种经修饰的神经毒素的单链多肽及其用途 |
| GB202103372D0 (en) | 2021-03-11 | 2021-04-28 | Ipsen Biopharm Ltd | Modified clostridial neurotoxins |
| GB202104294D0 (en) | 2021-03-26 | 2021-05-12 | Ipsen Biopharm Ltd | Clostridial neurotoxins comprising an exogenous activation loop |
| GB202214232D0 (en) | 2022-09-28 | 2022-11-09 | Ispen Biopharm Ltd | Clostridial neurotoxins comprising an activating exogenous protease cleavage site |
| GB202214229D0 (en) | 2022-09-28 | 2022-11-09 | Ipsen Biopharm Ltd | Clostridial neurotoxins comprising an activating endosomal protease cleavage site |
| EP4593873A1 (en) | 2022-09-30 | 2025-08-06 | Ipsen Biopharm Limited | Clostridial neurotoxin for use in a treatment of bladder pain syndrome |
| GB202318884D0 (en) | 2023-12-11 | 2024-01-24 | Ipsen Biopharm Ltd | Formulation |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2267008B1 (en) | 1999-08-25 | 2014-07-02 | Allergan, Inc. | Activatable recombinant neurotoxins |
| GB9921592D0 (en) | 1999-09-13 | 1999-11-17 | Microbiological Res Authority | Preparation of highly pure toxin fragments |
| US20080038274A1 (en) * | 1999-09-23 | 2008-02-14 | Foster Keith A | Inhibition of secretion from non-neuronal cells |
| US7273722B2 (en) | 2000-11-29 | 2007-09-25 | Allergan, Inc. | Neurotoxins with enhanced target specificity |
| GB0321344D0 (en) * | 2003-09-11 | 2003-10-15 | Health Prot Agency | Re-targeted toxin conjugates |
| US6991789B2 (en) * | 2004-06-29 | 2006-01-31 | Allergas, Inc. | Methods of modulating intracellular degradation rates of toxins |
| US20060024331A1 (en) | 2004-08-02 | 2006-02-02 | Ester Fernandez-Salas | Toxin compounds with enhanced membrane translocation characteristics |
| EP1982997B1 (en) | 2004-09-01 | 2012-08-08 | Allergan, Inc. | Degradable clostridial toxins |
| GB0426397D0 (en) | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
| BRPI0915142A8 (pt) | 2008-06-12 | 2018-01-02 | Syntaxin Ltd | Polipeptídeos, ácido nucleico e usos dos mesmos |
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2009
- 2009-02-23 GB GBGB0903006.5A patent/GB0903006D0/en not_active Ceased
- 2009-12-16 WO PCT/GB2009/002892 patent/WO2010094905A1/en not_active Ceased
- 2009-12-16 US US13/202,696 patent/US9849163B2/en active Active
- 2009-12-16 EP EP09799683.9A patent/EP2398495B2/en active Active
- 2009-12-16 CA CA2753101A patent/CA2753101C/en not_active Expired - Fee Related
- 2009-12-16 JP JP2011550638A patent/JP5764072B2/ja not_active Expired - Fee Related
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- 2009-12-16 AU AU2009340404A patent/AU2009340404B2/en not_active Ceased
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2016
- 2016-04-28 US US15/141,268 patent/US10744190B2/en active Active
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| CA2753101C (en) | 2019-02-19 |
| US20120128649A1 (en) | 2012-05-24 |
| ES2537338T3 (es) | 2015-06-05 |
| CA2753101A1 (en) | 2010-08-26 |
| US20160279208A1 (en) | 2016-09-29 |
| JP2012518403A (ja) | 2012-08-16 |
| EP2398495B2 (en) | 2018-07-11 |
| GB0903006D0 (en) | 2009-04-08 |
| US10744190B2 (en) | 2020-08-18 |
| ES2537338T5 (es) | 2018-11-21 |
| EP2398495B1 (en) | 2015-04-29 |
| WO2010094905A1 (en) | 2010-08-26 |
| EP2398495B8 (en) | 2015-06-17 |
| EP2398495A1 (en) | 2011-12-28 |
| US9849163B2 (en) | 2017-12-26 |
| AU2009340404A1 (en) | 2011-09-08 |
| AU2009340404B2 (en) | 2016-01-14 |
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