JP5712659B2 - Container rotary mixer and filler slurry mixing method - Google Patents

Description

  The present invention relates to a container rotary mixer that rotates a container filled with a slurry to be mixed and mixes the slurry to be mixed in the container. Moreover, this invention relates to the method of mixing the filler slurry of a liquid chromatography using this container rotary mixer.

  As a method of mixing a liquid and powder or granules to prepare a uniform slurry, the object to be mixed is transferred from the container originally containing the object to be mixed to the container for stirring, A technique is known in which a stirring blade is inserted into a container for stirring, or a stirring blade provided in the stirring container is rotated to stir and mix an object to be stirred (Japanese Examined Patent Publication No. 61-16496). ). In addition, there is also known a method in which an object to be mixed is transferred from a container originally containing an object to be mixed to a container for stirring, and then the container for stirring is rotated and mixed (actually). Kosho 61-27620).

In these techniques, it is necessary to transfer the object to be mixed from the container that originally contained the object to be mixed to the mixing container. For this reason, in addition to the time required for the transfer, liquid and powder may spill during the transfer operation, and the powder may rise as dust in the atmosphere. If the liquid or powder is harmful to the human body or the workplace, safety protection equipment, leakage prevention equipment, etc. are required, which complicates the work and requires countermeasure costs. In addition, the amount that spills or rises as dust causes loss of raw materials, which increases the manufacturing cost.

  There is also known a technique in which a mixing container is fixed to a basket having a certain shape and size, and a mixing basket is lifted and mixed (JP-A-1-127030). In this method, since it is not necessary to transfer the object to be mixed to the mixing container, there is no leakage or soaring of the object to be mixed, but the shape and size of the container to be mixed and the shape of the basket of the agitator And it is necessary to match the size. Therefore, it is necessary to arrange the baskets according to the shape and size of the container containing the object to be mixed, so it costs not only to prepare a large number of baskets, but also requires storage space and replacement work. , Time and labor load also increase.

  By the way, conventionally, in order to fill a column of a liquid chromatography apparatus for pharmaceutical purification, a filler slurry is mixed and prepared, and this filler slurry is injected into the column. Since it is necessary to mix the filler slurry encapsulated in the container without exposing it to the atmosphere, the mixing takes time and effort. In other words, in order to mix a filler slurry for pharmaceutical refining, it is impossible to stir with a stirrer or the like and it cannot be stirred in the state exposed to the atmosphere. Shake and stir. If the amount of filler used is small and a small size container is agitated, this work effort is not significant. However, in the case of a large chromatographic column such as a 100 liter size, the 20 liter container is shaken many times and stirred, which requires significant labor. In addition, the filler is often fine particles of about several to 100 μm, and may be solid-liquid separated in a sealed container. The solid-liquid separated filler hardens and cannot be easily reslurried. If the packing material is a very soft natural material such as agarose or sepharose, there is also a problem that if the stirring bar is inserted and stirred, the packing material is damaged and there is a high risk of reducing the separation performance of the chromatography device. is there. There is also a problem that separation performance deteriorates if foreign matter is mixed in when a stir bar or the like is inserted.

Japanese Patent Publication No. 61-16496 Shoko 61-27620 JP-A-1-127030

  The present invention does not transfer the mixed slurry to the mixing container, does not insert a stirring device such as a stirring blade into the mixed slurry, and the shape and size of the container containing the mixed object is Even if it is various, the container can be installed by one fixing mechanism, and the container rotation mixer that can achieve safety, economy, work operability improvement, and space saving, and this container rotation It is an object of the present invention to provide a method for mixing a filler slurry for liquid chromatography using a mixer.

The container rotary mixer according to claim 1 is a container rotary mixer that rotates a container enclosing the slurry to be mixed and mixes the slurry to be mixed. The container rotary mixer is held by a pair of disk-shaped support plates and each support plate. A holding plate movable in the approaching direction, a container fixing means for holding the container between the holding plates, and a pair of rotations on which the container fixing means can be placed and rotated and it has a rotating means comprising a shaft, placing the container fixing means wherein the container is being sandwiched and fixed between the retaining disc on said pair of rotating shafts, thereby rotating the rotating shaft in the circumferential direction Thus, the container fixing means and the container are configured to rotate around the axis of the support plate .

According to a second aspect of the present invention, there is provided a method for mixing a filler slurry, wherein the container slurry mixer is used to mix a liquid chromatography filler slurry as the slurry to be mixed.

  According to the container rotary mixer of the present invention, the container in which the slurry to be mixed is sealed is rotated, so that the slurry to be mixed can be mixed without being exposed to the atmosphere. In the present invention, the container is fixed by the fixing means, and the fixing means is rotated. Therefore, even if the shape and size of the container are different, the container can be rotated and the mixed slurry in the container can be mixed. . Therefore, the container rotary mixer of the present invention is suitable for mixing the filler slurry for liquid chromatography.

It is a perspective view of the container fixing means of the container rotation mixer which concerns on embodiment of this invention. It is a perspective view of the container fixing means of FIG. 1 in a state where the container is fixed. It is the III-III arrow directional view of FIG.

  Hereinafter, embodiments will be described with reference to FIGS. FIG. 1 is a perspective view of a container fixing means 1 of a container rotary mixer according to an embodiment. The container fixing means 1 includes a pair of disc-shaped support plates 2 and 2 arranged in parallel and coaxially with the plate surfaces facing each other, and a holding plate which is held by the support plates 2 and 2 and arranged face-to-face 3 and 3. The outer periphery of the support board 2 is a perfect circle. The support plates 2 and 2 are connected to each other by a plurality (three in this embodiment) of tie rods 4 and nuts 5 screwed to both ends of each tie rod 4. The tie rod 4 passes through the peripheral edge of the support board 2.

  A female screw hole (not shown) penetrating through the support plate 2 in the axial direction is provided in a seat portion 2a provided in the shaft center portion of the support plate 2, and a bolt shape for supporting the holding plate is formed in the female screw hole. The support shaft 6 is screwed. A holding plate 3 is attached to the tip of the support shaft 6. A handle portion 6 a is provided at the rear end of the support shaft 6.

  After the container 10 in which the slurry to be mixed is sealed is disposed between the holding plates 3 and 3, the support shaft 6 is rotated to move one or both of the holding plates 3 and 3 toward each other. Two ways are held by the container fixing means 1. The fixing means 1 is placed on a pair of rotating shafts 7 and 7 and is held by the container fixing means 1 and the fixing means 1 by rotating the rotating shafts 7 and 7 in the circumferential direction as shown in FIG. The container 10 rotates about the axis of the fixing means 1 (the axis of the support plate 2) as shown by the arrow θ in FIG. 3, and the slurry to be mixed in the container 10 is stirred and mixed. Note that one of the rotary shafts 7 and 7 may be rotationally driven and the other may be driven and rotated, or both may be rotationally driven. In this way, the mixed slurry in the container 10 can be sufficiently mixed without being exposed to the atmosphere. According to this container rotary mixer, containers of different shapes and sizes can be fixed to the fixing means 1, and improvements in safety, economy, work operability, etc., and space saving can be achieved. Moreover, this fixing means 1 does not require a special rotation drive machine, and can be rotated using a commercially available general purpose rotary device.

  In addition, when the mixed slurry in the container 10 is a liquid chromatography filler slurry for pharmaceutical purification, the container rotary mixer is placed outside the clean room, and the contents are mixed using the container rotary mixer. It is possible to carry only the container 10 into the clean room, open the container 10 in the clean room, and inject it into the chromatography column in the clean room.

  In addition, it is preferable to provide the rubber plate which gave the concave step process to the surface which contacts the container 10 of the holding | maintenance board 3, for example. By doing so, even if the end surface of the container 10 containing the slurry to be mixed is somewhat uneven, a high holding and fixing ability can be exhibited. Examples of the concave step processing include a plurality of step portions provided concentrically with respect to the axis of the holding plate 3, but are not limited thereto. As the rubber material, soft materials such as EPDM rubber, silicone rubber, natural rubber, urethane rubber, chloroprene rubber, fluorine rubber, butadiene rubber, acrylic rubber, nitrile rubber, and isoprene rubber are suitable, but are not limited thereto. Absent.

  The holding plate 3 may be of a size that does not protrude from the periphery of the support plate 2 and does not touch the tie rod 4, and is not limited to a circular plate shape. For example, the holding plate 3 may be a square plate shape or other shapes. . Moreover, the container 10 should just be a shape which can be pinched | interposed between the holding | maintenance discs 3 and 3, and any of cylindrical shape, elliptic cylinder shape, square cylinder shape, polygonal cylinder shape, etc. may be sufficient as it.

  The material of the support board 2 and the holding board 3 can use metals, such as stainless steel, steel, and aluminum, polypropylene, a fluororesin, an acrylic resin, polysulfone, a polycarbonate, etc., However, It is not limited to these. The tie rod 7 and the support shaft 6 may be any material that can ensure strength, and stainless steel, other steel, aluminum, and the like are suitable, but are not limited thereto.

DESCRIPTION OF SYMBOLS 1 Fixing means 2 Support plate 3 Holding plate 6 Support shaft 6a Handle part 7 Rotating shaft 10 Container

Claims (2)

In a container rotary mixer that rotates a container enclosing the slurry to be mixed to mix the slurry to be mixed,
A container fixing means for holding a pair of disk-shaped support plates, and a support plate held by each support plate and movable in the approaching direction ;
The vessel securing means is placed, and have a rotating means comprising a pair rotating shaft capable of rotating,
The container fixing means in which the container is sandwiched and fixed between the holding plates is placed on the pair of rotating shafts, and the rotating shafts are rotated in the circumferential direction so that the container fixing means and the container are supported by the container. A container rotating mixer characterized by being configured to rotate about the axis of the panel . A method of mixing a filler slurry, comprising mixing a liquid chromatography filler slurry as the slurry to be mixed using the container rotary mixer according to claim 1 .

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