JP5704993B2 - Control device, control method, and control program for optical coherence tomographic image generation apparatus - Google Patents

Description

  The present invention relates to an optical coherence tomographic image generation apparatus, and more particularly to a control apparatus, a control method, and a control program for an optical coherence tomographic image generation apparatus.

  2. Description of the Related Art Conventionally, an optical coherence tomographic image generation apparatus (Optical Coherence Tomography: hereinafter referred to as an OCT apparatus) is applied in ophthalmic medicine such as tomographic measurement of an eyeball cornea or a retina in the field of a living body. OCT is a method that enables non-invasive and non-contact diagnosis by irradiating a living tissue with light. Diagnostic methods other than OCT include CT (Computed Tomography) with a resolution of 200 microns or less, MRI (Magnetic Resonance Imaging) with a resolution of 800 microns or less, and PET (Positron Emission Tomography) with a resolution of 1000 microns or less. Can achieve a resolution of several to several tens of microns, which is much better than these, and can display high-definition images with high resolution. This OCT method is broadly divided into TD (Time Domain) -OCT and FD (Frequency Domain) -OCT. The latter FD-OCT includes SD (Spectrum Domain) -OCT and SS (Swept Source) -OCT. It is known that it is classified into

For example, SS-OCT is a method of specifying an optical path length by using a laser light source capable of continuously sweeping a wavelength (wave number), subjecting spectrum information acquired by a detector to FFT (Fast Fourier Transform) processing. SS-OCT has features such as higher resolution and measurement in real time without exposure compared to, for example, X-ray imaging apparatuses and CT apparatuses that are widely used in dentistry.
In addition, the TD-OCT described above has been tried for dental use, but since SS-OCT can acquire data with higher sensitivity and higher speed than TD-OCT, motion artifact (ghost due to body movement) It is characterized by being strong.

The OCT apparatus obtains one tomographic image as a direction perpendicular to the laser irradiation direction (vertical direction or depth direction of the subject) to the front of the subject, and the width direction (left and right direction of the subject) and depth. Since two-dimensional mechanical scanning in the direction (front-rear direction of the subject) is necessary, there is a problem that imaging and thus diagnosis takes time.
In an OCT apparatus for ophthalmology, a technique for acquiring a schematic image of a subject before capturing a detailed image used for diagnosis is known (see Patent Document 1).
The imaging apparatus described in Patent Literature 1 includes a cross-sectional image acquisition unit realized by an OCT apparatus, and a front image acquisition unit realized by a fundus camera for acquiring a front image, an SLO (Scanning Laser Ophthalmoscope), and the like. The front image acquisition unit acquires a schematic image of the subject. This imaging apparatus displays a front image (fundus surface image), which is a schematic image of a subject, and a cross-sectional image (tomographic image) side by side on a GUI (Graphical User Interface) screen. Then, the photographing position of the subject to be subjected to detailed photographing is set in the schematic image (front image).

  In the field of dentistry, the dental optical diagnostic device handpiece is provided with OCT means, and the means for positioning the optical diagnostic location of the tooth part is an imaging method using a camera, and an imaging camera for acquiring a surface image is provided inside. (See Patent Document 2). Therefore, a camera image can be used for prior positioning.

JP 2010-142428 A Utility Model Registration No. 3118718

  However, the conventional OCT apparatus can display a tomographic image and an image showing the tomographic position side by side, but the user designates a desired tomographic position in the image showing the tomographic position, and the tomographic image at the designated tomographic position. Could not be displayed side by side with an image showing the position of the fault. In addition, when a surface image or front image of a subject is simply used as an image showing the tomographic position of the photographed subject, an image acquired by photographing (main photographing) for measuring a detailed image used for diagnosis is a tomographic image. Nevertheless, since the image acquired in advance is a surface image, there is a problem that it takes time until a desired tomographic image used for diagnosis can be acquired.

  Therefore, an object of the present invention is to provide a control device, a control method, and a control program for an optical coherence tomographic image generation apparatus that can solve the above-described problems and can acquire a desired tomographic image of a subject at high speed. .

In order to solve the above problems, a control device of an optical coherence tomographic image generation device according to the present invention includes an optical unit including a light source that periodically irradiates a subject with laser light and a detector that detects internal information of the subject. Including a scanning mechanism for two-dimensionally scanning the laser light, a probe for guiding the laser light from the optical unit to the subject and guiding the light reflected by the subject to the optical unit, and the scanning in synchronization with the laser light. Control including a control device that performs imaging by controlling a mechanism and generates a light coherence tomographic image of the subject from data obtained by converting a detection signal of the detector, and a display device that displays the optical coherence tomographic image A control unit of an optical coherence tomographic image generation apparatus comprising a unit, and performs imaging in a predetermined imaging mode based on an external input A shadow control unit; and an image processing unit that performs image processing on the detection signal acquired by photographing, wherein the image processing unit is a two-dimensional image of a scan plane in a direction perpendicular to the optical axis of the subject. and the said surface of the object information which the laser beam is irradiated, by summing the depth direction of the data of the three-dimensional image of the object What direction information and are combined image der along the optical axis in the subject On- face image generation means for generating an on-face image that is the obtained two-dimensional image, and a tomographic position line that draws and superimposes the tomographic position of the optical coherence tomographic image in a line on the on-face image displayed on the display device An instruction for selection and movement with respect to the line of the tomographic position displayed on the display device and the generation means, and based on the information of the selected and moved line, An optical interference tomographic image generating means from the output unit of converting the detection signal data to generate said optical coherent tomography, comprising a, acquired by the probe in the scanning mode that does not assume data storage of the detection signal obtained by photographing The on-face image generated by performing image processing on the information and the optical coherence tomographic image of the tomographic position designated by the line on the on- face image are displayed on the display device as a real-time image .

  According to such a configuration, the control device of the optical coherence tomographic image generation device uses the on-face image generation unit of the image processing unit to obtain information on the surface of the subject along the optical axis of the subject as a two-dimensional image of the scan surface. An on-face image, which is an image combined with direction information, is generated. This on-face image is generated using not only information on the outer surface of the subject but also internal information as data obtained by image processing of a signal detected by OCT. Therefore, an on-face image can be used for measurement and diagnosis. Further, the control device of the optical coherence tomographic image generation apparatus draws and superimposes the tomographic position of the optical coherent tomographic image in a line shape on the on-face image by the tomographic position line generation unit of the image processing unit. Thereby, an on-face image can be used as an image showing a tomographic position. In addition, the control device of the optical coherence tomographic image generation device receives an instruction for selection and movement of the displayed line of the tomographic position by the optical coherence tomographic image generation unit of the image processing unit, and the light at the tomographic position specified by the line Generate coherent tomographic images. Here, the selection and movement instructions for the line are performed by the user on the GUI screen using a pointing device or the like. Further, according to such a configuration, it is not necessary to provide a member such as a dedicated camera for acquiring an image showing the tomographic position in the optical coherent tomographic image generation device. Therefore, for example, there is no need to provide a CCD camera, a CMOS camera, or the like in the probe, so that the probe can be reduced in size.

  In the control apparatus for an optical coherence tomographic image generation device according to the present invention, the on-face image generation unit generates a 3D image of the subject in the process of generating the on-face image, and the tomographic position line generation unit includes: The tomographic position of the optical coherent tomographic image is drawn in a line and superimposed on the 3D image of the subject displayed on the display device in synchronization with the line displayed on the on-face image, and the optical coherent tomographic image The generation unit receives an instruction to select and move the line at the tomographic position in the 3D image displayed on the display device, and converts the detection signal of the detector based on information on the selected and moved line Generating the optical coherence tomographic image from the data, and superimposing the image on the tomographic plane along the line of the 3D image exposed by cutting out the 3D image. Masui.

  According to this configuration, the control device of the optical coherence tomographic image generation device displays the same line on the 3D image in synchronization with the line indicating the tomographic position on the on-face image. When the line on the 3D image is moved, the control device generates a tomographic image at the destination tomographic position and displays the tomographic image on the 3D image so as to be visible. In other words, the optical coherence tomographic image is displayed on a cross-section exposed by cutting out a part of the 3D image of the subject. Therefore, the user can intuitively understand which tomographic plane of which part of the subject is the displayed optical coherence tomographic image, and the operability is improved.

  Further, the control device of the optical coherence tomographic image generation device according to the present invention is based on the data stored in the storage unit as data obtained by converting the detection signal of the detector when the image processing unit images the subject. Preferably, the image processing apparatus further includes a rendering unit that creates a 3D image of the subject by rendering.

  According to such a configuration, the control device of the optical coherence tomographic image generation device can display a 3D image of the subject on the display device in addition to the on-face image and the optical coherence tomographic image, which are images showing the tomographic position. . Therefore, the user can intuitively understand which tomographic plane of which part of the subject is the displayed optical coherence tomographic image, and the operability is improved.

  Further, in the control apparatus for an optical coherence tomographic image generation device according to the present invention, the imaging control unit causes the scanning mechanism to scan the imaging target range of the subject at a predetermined pitch in order to measure internal information of the subject. First shooting control means for starting shooting when it is determined that an input of an instruction has been received, and ending shooting at a shooting time corresponding to the predetermined pitch; and for the scanning mechanism, the shooting target range is coarser than the predetermined pitch. A second shooting control unit that starts shooting when it is determined that an input of a preview instruction for scanning at a pitch has been received and ends shooting when it is determined that an input of an instruction to release the preview instruction is received; Is preferred.

  According to such a configuration, the control device of the optical coherence tomographic image generation apparatus starts photographing the subject when the first photographing control unit receives an input of a measurement instruction, and the scanning mechanism scans at a predetermined pitch. The acquired detection signal is image-processed by the image processing means, thereby displaying an optical coherence tomographic image of the subject on the display device with a predetermined resolution. At this time, since the photographing is finished with the photographing time corresponding to the scanning pitch of the scanning mechanism, the still image of the optical coherence tomographic image is displayed on the display device after the photographing is finished. In addition, the control device of the optical coherence tomographic image generation device starts photographing the subject when the second photographing control unit receives an input of a preview instruction, and the scanning mechanism obtains by scanning at a pitch coarser than a predetermined pitch. The detected signal is subjected to image processing by image processing means, so that an optical coherence tomographic image of the subject is displayed on the display device at a resolution lower than the predetermined resolution. At this time, the optical coherence tomographic image displayed by the preview instruction uses the detection signals scanned at a coarser pitch than the optical coherence tomographic image displayed by the measurement instruction, and therefore can be displayed at high speed. Further, since the low-resolution optical coherence tomographic image is continuously photographed and processed until an input of an instruction to cancel the preview instruction is received, the photographed optical coherent tomographic image can be displayed as a real-time moving image. Note that the resolution does not change in the direction along the optical axis of the subject.

  Further, the control device of the optical coherence tomographic image generation device according to the present invention is configured so that the control unit is communicably connected to the imaging control unit in a wired or wireless manner in a configuration for receiving the input of the preview instruction and the imaging instruction. The foot controller has a first switch and a second switch, and when the user operates the first switch or the second switch with a foot, A first switch signal or a second switch signal corresponding to the switch is notified to the photographing control means, and the second photographing control means receives the input of the first switch signal from the foot controller. When it is determined that the input of the preview instruction has been received, and the input of the second switch signal is received, It is determined that an input of an instruction to cancel the view instruction has been received, and it is determined that the first imaging control unit has received an input of the measurement instruction when receiving the input of the second switch signal from the foot controller. It is preferable.

  According to such a configuration, the control device of the optical coherence tomographic image generation device determines that the input of the preview instruction has been received by the second imaging control unit when the user operates the first switch of the foot controller with his / her foot. . Further, when the user operates the second switch of the foot controller with his / her foot, the first photographing control means determines that the preview instruction is canceled and the measurement instruction input is accepted. This allows the user to input a preview instruction or a measurement instruction by stepping on the foot controller even if both hands are blocked when the diagnostic probe unit is brought into contact with the patient during imaging. Or enter. Therefore, the operability is improved.

According to another aspect of the present invention, there is provided a method for controlling an optical coherence tomographic image generation apparatus, comprising: an optical unit including a light source that periodically irradiates a subject with laser light; a detector that detects internal information of the subject; Including a scanning mechanism that performs two-dimensional scanning, a probe that guides laser light from the optical unit to the subject and guides light reflected from the subject to the optical unit, and controls the scanning mechanism in synchronization with the laser light. And a control unit including a control unit that performs control to generate an optical coherence tomographic image of the subject from data obtained by converting the detection signal of the detector and a display unit that displays the optical coherence tomographic image. A method for controlling an optical coherence tomographic image generation device, wherein the control device performs imaging in a predetermined imaging mode based on an input from outside. An image processing step for performing image processing on the detection signal acquired by photographing, and the image processing step is performed as a two-dimensional image of a scan plane in a direction perpendicular to the optical axis of the subject. and information of the irradiated surface of the object was determined by summing the depth direction of the data of the three-dimensional image of the object What direction information and are combined image der along the optical axis in the object 2 An on- face image generation step of generating an on-face image that is a three- dimensional image, and a tomographic position line generation step of drawing and superimposing a tomographic position of the optical coherence tomographic image in a line on the on-face image displayed on the display device; , Receiving an instruction for selection and movement with respect to the line of the tomographic position displayed on the display device, and based on the information of the selected and moved line, In output device of an optical interference tomographic image generating step of generating the optical coherent tomography detection signal from the converted data, have a, the probe in the scanning mode that does not assume data storage of the detection signal obtained by photographing The on-face image generated by performing image processing on the acquired information and the optical coherence tomographic image at the tomographic position designated by the line on the on- face image are displayed on the display device as a real-time image .

  According to such a procedure, the control method of the optical coherence tomographic image generation apparatus is configured to follow the information on the surface of the subject and the optical axis of the subject as a two-dimensional image of the scan surface in the on-face image generation step of the image processing step. An on-face image, which is an image combined with information on the selected direction, is generated. Then, in the tomographic position line generation step, the tomographic position of the optical coherent tomographic image is drawn in a line shape and superimposed on the on-face image. Then, in the optical coherence tomographic image generation step, an instruction to select and move the displayed line is received, and an optical coherent tomographic image of the tomographic position designated by the line is generated. Here, unlike the simple surface image and the front image, the on-face image is generated using not only the information on the outer surface of the subject but also the internal information, so that it can be used for measurement and diagnosis. In addition, the user can instruct the selection and movement of the line by using a pointing device or the like on the GUI screen. Therefore, the user can designate a desired tomographic position by selecting and moving the line superimposed on the Onface image. Thereby, the user can quickly find a desired tomographic plane as an image of the tomographic plane of the subject, and can acquire a high-resolution desired tomographic image at high speed using the information.

  An optical coherence tomographic image generation device control program according to the present invention is a program for causing a computer to function as each unit of the control device of the optical coherence tomographic image generation device. By being configured in this way, a computer in which this program is installed can realize each function based on this program.

  According to the present invention, the control device of the optical coherence tomographic image generation device can acquire a desired tomographic image of a subject at high speed. In addition, according to the present invention, the operability is improved for the user, and the tomographic position of the optical coherence tomographic image displayed on the screen of the display device can be easily grasped.

1A and 1B are external views of an optical coherence tomographic image generation apparatus according to an embodiment of the present invention, in which FIG. 1A shows a single joint arm type and FIG. It is a block diagram which shows typically the unit structure of the optical coherence tomographic image generation apparatus which concerns on embodiment of this invention. It is a block diagram which shows the function of the OCT control apparatus which concerns on embodiment of this invention. It is explanatory drawing of imaging | photography by the optical coherence tomographic image generation apparatus which concerns on embodiment of this invention, Comprising: (a) is a figure which shows the kind of recording area, (b) is the schematic of the optical path of the laser beam inside a diagnostic probe Respectively. It is explanatory drawing of the production | generation process of the OCT image by the OCT control apparatus which concerns on embodiment of this invention. It is a flowchart which shows the flow of the arithmetic processing for the OCT control apparatus which concerns on embodiment of this invention to display an OCT image. It is a flowchart which shows the flow of the arithmetic processing for the OCT control apparatus which concerns on embodiment of this invention to display an on-face image. It is an example of the timing chart of the image processing by the OCT control apparatus which concerns on embodiment of this invention, Comprising: (a) is a scanning trigger of a light source output, (b) is a start trigger of DA conversion circuit output, (c) and (d ) Indicates analog output voltages in the X and Y directions by the galvanomirror control circuit, and (e) indicates a clock for generating an OCT image. It is a figure which shows the example of a screen display of the image information acquired by the preview imaging | photography of the OCT control apparatus which concerns on embodiment of this invention. It is a figure which shows the example of a screen display of the image information acquired by the main imaging | photography of the OCT control apparatus which concerns on embodiment of this invention.

  DESCRIPTION OF EMBODIMENTS Hereinafter, an embodiment for implementing an apparatus of the present invention (hereinafter referred to as “embodiment”) will be described in detail with reference to the drawings. In the following, 1. 1. Outline of OCT apparatus configuration 2. Configuration of OCT control device 3. Operation of OCT controller This will be described in detail in each chapter of screen display examples of the display device.

[1. Overview of OCT system configuration]
The outline of the configuration of the OCT apparatus (optical coherence tomographic image generation apparatus) will be described with reference to FIG. 1 and FIG. 2, assuming that a subject to be imaged by the OCT apparatus is a tooth to be diagnosed by a dental patient. As shown in FIGS. 1 and 2, the OCT apparatus 1 mainly includes an optical unit section (optical unit) 10, a diagnostic probe section (probe) 30, and a control unit section (control unit) 50.

<Optical unit section>
The optical unit (optical unit) 10 includes a light source, an optical system, and a detection unit to which each method of general optical coherence tomography can be applied. As shown in FIG. 2, the optical unit 10 includes a light source 11 that periodically irradiates a sample (subject) S with laser light, a detector (detector) 23 that detects internal information of the sample S, and a light source 11. An optical fiber and various optical components provided in the optical path between the detector 23 and the like are provided.

Here, an outline of the optical unit unit 10 will be described.
The light emitted from the light source 11 is divided into measurement light and reference light by a coupler 12 which is a light dividing means. The measurement light enters the diagnostic probe unit 30 from the circulator 14 of the sample arm 13. This measurement light is condensed on the sample S by the condenser lens 34 through the collimator lens 32 and the galvanometer mirror (scanning mechanism) 33 when the shutter 31 of the diagnostic probe unit 30 is open, and is collected again after being scattered and reflected there. It returns to the circulator 14 of the sample arm 13 through the optical lens 34, the galvanometer mirror 33, and the collimator lens 32. The returned measurement light is input to the detector 23 via the coupler 16.

  On the other hand, the reference light separated by the coupler 12 passes through the collimator lens 19 from the circulator 18 of the reference arm 17 and is condensed on the reference mirror 21 by the condenser lens 20, and after being reflected there, is again collected into the condenser lens 20 and the collimator lens 19. After that, the flow returns to the circulator 18. The returned reference light is input to the detector 23 via the coupler 16. That is, since the coupler 16 combines the measurement light scattered and reflected by the sample S and the reference light reflected by the reference mirror 21, the detector 23 detects the light (interference light) interfered by the combination. It can be detected as internal information of the sample S. Note that the polarization controller 15 of the sample arm 13 and the polarization controller 22 of the reference arm 17 are each installed to return the polarized light generated inside the OCT apparatus 1 including the diagnostic probe unit 30 to a state with less polarization. ing.

As the light source 11, for example, a laser light source for SS-OCT method can be used.
In this case, it is preferable that the light source 11 has a performance with a center wavelength of 1310 nm, a sweep wavelength width of 100 nm, a sweep speed of 50 kHz, and a coherence distance (coherent length) of 14 mm. Here, the coherent distance corresponds to a distance when the attenuation of the power spectrum is 6 dB. The coherent distance is preferably a highly coherent distance of 10 mm or more and less than 48 mm, but is not limited thereto. For example, when the subject is a molar, it is preferable to acquire data at a deeper position in the depth direction (optical axis direction), and if it is 10 mm or more, it is possible to photograph a tooth-specific item (such as caries). is there. Although an OCT apparatus equipped with a light source having a coherence distance of 48 mm or more is theoretically possible, this light source is an SS-OCT system that sweeps the wave number (wavelength) stepwise, so that the sweep speed and resolution are reduced. If the overall performance including the above is required for this light source, it is difficult to manufacture the light source itself, so it is realistic to set the coherence distance to less than 48 mm.

<Diagnostic probe part>
The diagnostic probe unit (probe) 30 includes a galvanometer mirror (scanning mechanism) 33 that two-dimensionally scans the laser beam, guides the laser beam from the optical unit unit 10 to the sample S, and reflects the light reflected by the sample S to the optical unit. It leads to the part 10.

  The diagnostic probe unit 30 is connected to the optical unit unit 10 and the control unit unit 50 by a cable 60 (see FIG. 1). The cable 60 includes an optical fiber connected to the optical unit unit 10 and a communication line connected to the control unit unit 50.

  At times other than during imaging, the diagnostic probe unit 30 is attached to the tip of the single joint arm 70 extending in the horizontal direction from the lower side of the display device 54 disposed at the upper portion of the OCT apparatus 1 as shown in FIG. Hold it in the holder. Thereby, at the time of accommodation, even if it is the long cable 60, it can accommodate without twisting a cable, and a storage space can be reduced.

  On the other hand, at the time of imaging, the user removes and grasps the diagnostic probe unit 30 from the holder of the single joint arm 70 and brings the diagnostic probe unit 30 into contact with the patient to prevent camera shake. At this time, the foot controller 80 (see FIG. 1) connected to the control unit 50 in a wired or wireless manner can be used to operate the photographing start button even if both hands of the user are blocked.

  When the OCT apparatus 1A shown in FIG. 1B is not in the middle of imaging, the diagnostic probe unit 30 includes an articulated arm 70A that extends horizontally from the upper side of the display device 54 disposed on the OCT apparatus 1A. The OCT apparatus 1 is the same as the OCT apparatus 1 shown in FIG. 1A except that it can be held by the tip holder. The articulated arm 70A has a longer length from the base end to the distal end holder than the single articulated arm 70, and is arranged at a higher position from the floor. Therefore, the drooping of the cable 60 can be reduced. As a merit that the cable 60 does not reach the floor in this way, a sanitary point can be mentioned. This also improves operability and prevents the cable 60 that has dropped from being stepped on by mistake.

  Specifically, as shown in FIG. 4B, the galvano mirror 33 provided in the diagnostic probe unit 30 is provided with an X-direction galvanometer mirror 33X and a Y-direction galvanometer mirror 33Y. Laser light emitted from the light source 11 is applied to the sample S (see FIG. 2; the same applies hereinafter) via the X-direction galvanometer mirror 33X and the Y-direction galvanometer mirror 33Y, and the nozzle tip of the diagnostic probe unit 30 (FIG. 4). The detector 23 obtains internal information in the depth direction (A direction) that proceeds inward from the surface of the sample S facing the left end in (b). As will be described later, data in the A direction consisting of 1152 points (hereinafter referred to as A line data) is acquired in one scan, and then image processing (FFT processing) of frequency analysis is performed to perform FFT processing of the data in the A direction. As a result, each data of 1024 points (hereinafter referred to as A line (1024 points FFT)) is acquired.

  Here, the X direction and the Y direction refer to the lateral direction (X axis direction, X axis direction, Y) on the surface of the sample S (see FIG. 4A) that the nozzle tip of the diagnostic probe unit 30 (the left end in FIG. 4B) faces directly. This corresponds to the horizontal direction in FIG. 4A and the vertical direction (Y-axis direction, vertical direction in FIG. 4A).

  The X-direction galvanometer mirror 33X is provided on the collimator lens 32 side. The X-direction galvanometer mirror 33X rotates a mirror surface (A-V plane) by motor drive with the A direction as an axis. At this time, the direction of the acquired data is data in the horizontal direction (X-axis direction) on the surface of the sample S, and is data in the B direction. If the operation rotation angle of the galvano mirror is, for example, -3 ° to + 3 ° and 128-point B-direction data is required, 158-point B-direction data (hereinafter referred to as B-line data) is acquired as described later. .

  The Y-direction galvanometer mirror 33Y is provided on the condensing lens 34 side, and rotates the mirror surface (BV plane) by motor drive with the B direction as an axis. At this time, the direction of the acquired data is data in the vertical direction (Y-axis direction) on the surface of the sample S, and is data in the V direction (hereinafter referred to as V line data).

<Control unit section>
As shown in FIG. 2, the control unit unit (control unit) 50 includes an AD conversion circuit 51, a DA conversion circuit 52, a galvano mirror control circuit 53, a display device 54, and an OCT control device 100.

  The AD conversion circuit 51 converts an analog output signal of the detector (detector) 23 into a digital signal. In the present embodiment, the AD conversion circuit 51 starts acquisition of a signal in synchronization with a trigger output from the laser output device that is the light source 11, and the timing of the clock signal ck that is also output from the laser output device. At the same time, the analog output signal of the detector (detector) 23 is acquired and converted into a digital signal. This digital signal is input to the OCT controller 100.

  The DA conversion circuit 52 converts the digital output signal of the OCT control apparatus 100 into an analog signal. In the present embodiment, the DA conversion circuit 52 converts the digital signal of the OCT control device 100 into an analog signal in synchronization with a trigger output from the laser output device that is the light source 11. This analog signal is input to the galvanometer mirror control circuit 53.

  The galvanometer mirror control circuit 53 is a driver that controls the galvanometer mirror 33 of the diagnostic probe unit 30. The galvano mirror control circuit 53 drives the motor of the X direction galvano mirror 33X or the Y direction galvano mirror 33Y in synchronization with the output period of the laser emitted from the light source 11 based on the analog output signal of the OCT control device 100. Alternatively, a motor drive signal for stopping is output.

  The galvano mirror control circuit 53 performs processing for changing the angle of the mirror surface by rotating the axis of the X direction galvano mirror 33X, and processing for changing the angle of the mirror surface by rotating the axis of the Y direction galvano mirror 33Y. Do it at different times. These processes of the galvanometer mirror control circuit 53 are simply referred to as galvanometer mirror X and Y axis changes. An example of timing for changing the galvanometer mirror X and Y axes will be described later.

  The display device 54 displays an optical coherence tomographic image (hereinafter referred to as an OCT image) generated by the OCT control device 100. The display device 54 includes, for example, a liquid crystal display (LCD), an EL (Electronic Luminescence), a CRT (Cathode Ray Tube), a PDP (Plasma Display Panel), and the like.

  The OCT control apparatus 100 is a control apparatus for the OCT apparatus 1 and performs imaging by controlling the galvanometer mirror 33 in synchronization with the laser beam, and also converts the detection signal of the detector 23 into an OCT image of the sample S. The control which produces | generates is performed.

[2. Configuration of OCT controller]
As shown in FIG. 3, the OCT control apparatus 100 includes a computer including an input / output unit 110, a storage unit 120, and a calculation unit 130, and a program installed in the computer.

The input / output unit 110 is an interface that transmits and receives various types of information to and from the outside.
The storage unit 120 stores prestored data such as the above-described program, patient personal information 122 input from the input device M such as a mouse, calculation processing results (for example, image information 123) by the calculation unit 130, and other various types of information. For this purpose, a memory such as a RAM (Random Access Memory) and a ROM (Read Only Memory), a hard disk, and the like are provided.

  The calculation means 130 is composed of, for example, a CPU (Central Processing Unit), a GPU (Graphics Processing Unit), and the like, and includes a photographing control means 140, an image processing means 150, and a file creation processing means 160.

  The imaging control unit 140 performs imaging in a predetermined imaging mode based on an external input. The imaging control unit 140 includes a first imaging control unit 141, a second imaging control unit 142, and a scanning area selection control unit. 143.

  The first imaging control unit 141 starts imaging when it is determined that an input of a measurement instruction for scanning the imaging target range of the sample S at a predetermined pitch is received by the galvanometer mirror 33 in order to measure the internal information of the sample S. Control for ending the shooting at the shooting time corresponding to the predetermined pitch is performed. The first photographing control unit 141 causes the image processing unit 150 to perform image processing on the detection signal acquired by photographing. Based on this measurement instruction, the image processing means 150 performs image processing on the detection signal obtained by scanning the galvano mirror 33 at a predetermined pitch, thereby displaying the optical coherence tomographic image of the sample S on the display device 54 at a predetermined resolution. can do. The mode that operates according to this measurement instruction is one of the predetermined shooting modes.

In the present embodiment, the imaging mode includes three measurement modes of 200 measurement, 300 measurement, and 400 measurement as an example when the light source 11 has a sweep speed of 50 kHz.
At the time of 200 measurement, A line data is acquired at a point of 200 × 200 pixels corresponding to the surface of the sample S, and the image information is displayed.
At the time of 300 measurement, A line data is acquired at a point of 300 × 300 pixels corresponding to the surface of the sample S, and the image information is displayed.
At 400 measurement, A line data is acquired at a point of 400 × 400 pixels corresponding to the surface of the sample S, and the image information is displayed.
Here, the detection signal acquired by photographing in one of the measurement modes is subjected to image processing by the image processing means 150.

  The second shooting control unit 142 starts shooting when it determines that it has received an input of a preview instruction to cause the galvano mirror 33 to scan the shooting target range at a pitch coarser than the predetermined pitch, and inputs an instruction to cancel the preview instruction When it is determined that an image has been received, control for ending the shooting is performed. The second photographing control unit 142 causes the image processing unit 150 to perform image processing on the detection signal acquired by photographing. Based on the preview instruction, the detection signal obtained by scanning the galvano mirror 33 at a pitch coarser than the predetermined pitch is subjected to image processing by the image processing means 150, whereby the sample S is scanned at a resolution lower than the predetermined resolution. The optical coherence tomographic image can be displayed on the display device 54. Note that the low-resolution image displayed by the preview instruction is the same as the resolution in the measurement mode in the direction along the optical axis in the sample S (data in the A direction). The mode that operates in response to the preview instruction is one of predetermined shooting modes.

Hereinafter, this mode is referred to as a preview mode.
In the present embodiment, the preview mode acquires A line data at points of, for example, 128 × 128 pixels corresponding to the surface of the sample S when the light source 11 has a sweep speed of 50 kHz, and displays the image information. In the present embodiment, the preview mode is terminated when any of the measurement modes is entered by the above-described measurement instruction. That is, the instruction to cancel the preview instruction is also used as the measurement instruction.

  Although details will be described later, in this embodiment, the operation button “Preview” (see FIG. 9) or the operation button “Measure” (see FIG. 9) on the GUI screen is clicked with the input device M such as a mouse. A preview instruction or a measurement instruction can be input to the imaging control unit 140.

  In the present embodiment, a preview instruction or a measurement instruction can be input to the imaging control unit 140 from the foot controller 80 that is connected to the control unit 50 so as to be wired or wirelessly communicable. Specifically, the foot controller 80 has a first switch and a second switch, and corresponds to any one of the switches when the user operates the first switch or the second switch with a foot. The first switch signal or the second switch signal is notified to the imaging control means 140. As a result, when receiving the first switch signal from the foot controller 80, the second imaging control unit 142 determines that the preview instruction input has been received, and when receiving the second switch signal input. It is determined that an instruction to cancel the preview instruction has been received. The first imaging control unit 141 determines that the input of the measurement instruction has been received when the input of the second switch signal is received from the foot controller 80. At the time of actual photographing, the user needs to bring the diagnostic probe unit 30 into contact with the patient in order to prevent camera shake, etc., but the user's hands are blocked by controlling the foot controller 80 in this way. Even if the foot controller 80 is stepped on with a foot, a preview instruction or a measurement instruction can be input.

The foot controller 80 may be, for example, a parallel type in which two pedals (general foot switches) that can be switched on / off operated with a foot are arranged in parallel corresponding to the first and second switches, respectively. good it may be of two-stage depression method also serves as a second switch and the first switch contact in one pedal operated by a foot (foot switch).
In the case of the parallel system, the user depresses the foot switch in accordance with each operation of the preview instruction and the measurement instruction.
In the case of the two-step depression method, when the user depresses the foot switch by one step, a first switch signal corresponding to the depression is notified to the imaging control means 140. In addition, when the user steps deeper than the first step, the second switch signal is notified to the imaging control unit 140. Hereinafter, the foot controller 80 will be described as being a two-step depression method.

  The scanning area selection control unit 143 accepts an input of an area selected by the user from a plurality of areas having different predetermined areas as the imaging target range of the sample S, and the galvano mirror 33 according to the accepted area. The control for selecting the scanning range is performed. The scanning area selection control unit 143 outputs a control signal (analog signal) synchronized with the output period of the laser emitted from the light source 11 to the galvanometer mirror control circuit 53.

  In the example shown in FIG. 4A, as the range scanned by the galvanometer mirror 33, the surface of the sample S is the narrowest range (S: small), the middle range (M: middle), and the widest range (L: large). ) Can be selected from three stages. In this case, the operation rotation angles of the X-direction galvanometer mirror 33X and the Y-direction galvanometer mirror 33Y are set in a range of, for example, -1 ° to + 1 °, a range of -2 ° to + 2 °, and a range of -3 ° to + 3 °. By doing so, it is possible to designate a recording area in three stages of SML. According to the S shooting corresponding to the narrowest range, it is possible to acquire a higher resolution image than the image acquired during the L shooting corresponding to the widest range. For example, when the measurement mode at the time of 400 measurement (400 × 400 pixel points) is selected, in the range S where the scanning area is the narrowest, 400 × 400 pixel imaging is performed in the range of the operation rotation angle of −1 ° to + 1 °. Become. In the measurement mode at the time of 400 measurement, when the range L having the widest scanning area is selected, 400 × 400 pixels are imaged in the operation rotation angle range of −3 ° to + 3 °. That is, in the narrowest range S, the number of pixels per unit area is larger than that in the widest range L, and a high-resolution image can be obtained. Therefore, it is possible to display the targeted region of interest at a higher resolution by photographing in the widest range L, determining the target of the region of interest in the subject, and then narrowing down in the narrowest range S.

The image processing means 150 performs image processing on the detection signal acquired by photographing.
The image processing unit 150 obtains an OCT image of the tomographic plane in the direction along the optical axis in the sample S and a two-dimensional image of the scan plane in the direction perpendicular to the optical axis of the sample S from the data acquired by photographing the sample S. And a 3D image of the sample S are generated, and control is performed to display each generated image as image information of the sample S on a one-screen display of the display device 54. For this purpose, as shown in FIG. 3, the image processing unit 150 includes an on-face image generation unit 151, an OCT image generation unit 152, a rendering unit 153, and a tomographic position line generation unit 154.

The on-face image generation means 151 includes information on the surface of the sample S irradiated with the laser light and the light in the sample S as a two-dimensional image of the scan plane in the direction (B direction, V direction) perpendicular to the optical axis in the sample S. An on-face image, which is an image combined with information in a direction along the axis (direction A), is generated.
In the present embodiment, the on-face image generation unit 151 averages the values indicated by the respective data (A-line data described later) in the direction along the optical axis in the sample S acquired by photographing the sample S. The on-face image is generated by obtaining each of the two-dimensional directions scanned by the galvanometer mirror 33. The generated on-face image is displayed on the display device 54. The process flow for generating an on-face image will be described later. As will be described later, a 3D image of the sample S is generated in the process of generating the on-face image.

  The OCT image generation unit 152 generates an OCT image (optical coherence tomographic image) of a tomographic plane in the direction along the optical axis in the sample S from data acquired by photographing the sample S. The generated OCT image is displayed on the display device 54. The process flow for generating the OCT image will be described later.

The rendering unit 153 creates a 3D image of the designated sample S from the data stored in the storage unit 120 after shooting, and displays the 3D image on the display device 54.
The tomographic position line generation unit 154 draws and superimposes the tomographic position of the OCT image in a line on the on-face image displayed on the display device 54.
In the present embodiment, the OCT image generation unit 152 receives an instruction to select and move the tomographic position line 901 generated by the tomographic position line generation unit 154 (see the lower screen in the center of FIG. 9), and selects and moves. Based on the line information, an OCT image (see the upper screen in the center of FIG. 9) is generated from the data obtained by converting the detection signal of the detector 23.

Further, in the present embodiment, the tomographic position line generation unit 154 performs 3D of the sample S displayed on the display device 54 in synchronization with the line 901 (see the lower screen in the center of FIG. 9) displayed on the Onface image. The tomographic position of the OCT image is drawn and superimposed on the image in a line (see the screen on the left side of FIG. 9).
In the 3D image displayed on the display device 54, the OCT image generation unit 152 receives an instruction to select and move the line 901 at the tomographic position, and outputs a detection signal from the detector 23 based on the information on the selected and moved line. An OCT image is generated from the converted data, and is superimposed on a tomographic plane along the line 901 of the 3D image that is exposed by cutting out the 3D image (see the screen on the left side of FIG. 9).

  The file creation processing unit 160, before photographing the sample S, which is a tooth to be diagnosed by the patient, the patient's personal information input by the user from the input device M such as a mouse or the patient's tooth number to be photographed. A patient file 121 including personal information 122 is created. The mode that operates by this input operation is the input mode.

  The file creation processing unit 160 stores the patient personal information 122 input before imaging and the captured image information 123 in the storage unit 120 in association with the patient file 121 in accordance with the saving operation by the user. The mode that operates in this saving operation is the saving mode. The number of stored patient files 121 is arbitrary.

  The file creation processing unit 160 searches the captured image information 123 stored in the patient file 121 and displays the image information 123 on the display device 54 in accordance with a search operation by the user. A mode that operates in this search operation is a search mode.

[3. Operation of OCT controller]
<Operation mode>
The outline of the operation mode of the OCT control apparatus 100 of this embodiment is demonstrated.
≪Preview mode≫
The OCT control apparatus 100 starts imaging when it is determined that an input of a preview instruction is received from the outside, and ends imaging when it is determined that an input of a measurement instruction is received. In addition, the OCT control apparatus 100 performs image processing on the detection signal acquired by photographing in the preview mode. An example of screen display on the display device 54 is shown in FIG. Although details will be described later, FIG. 9 shows an online screen. Here, online means that the line of the diagnostic probe unit 30 -the optical unit unit 10 -the control unit unit 50 -the display device 54 is connected, and the information acquired by the diagnostic probe unit 30 is displayed on the display device 54 in real time as it is. Means that.

≪Measurement mode≫
The OCT control apparatus 100 starts imaging when it is determined that an input of a measurement instruction is received from the outside, and ends imaging at an imaging time corresponding to a predetermined resolution. In addition, the OCT control apparatus 100 performs image processing on the detection signal acquired by imaging in the measurement mode. Examples of screen display on the display device 54 are shown in FIGS. Although details will be described later, FIG. 9 shows an online screen, and FIG. 10 shows an offline screen. Here, offline means that the information acquired by the diagnostic probe unit 30 is not displayed on the display device 54 as it is, but the information acquired online and stored in the storage unit 120 is temporarily removed from the online, , Which means reading out and displaying on the display device 54.

≪Other modes≫
The input mode is an operation mode performed before the preview mode or the measurement mode. In the input mode, the OCT control apparatus 100 receives input of patient personal information 122 such as patient personal information and a tooth number to be imaged from the outside, and creates a patient file 121.
The storage mode is an operation mode performed after the measurement mode. In the storage mode, the OCT control apparatus 100 receives an input of an operation for storing image information from the outside, and associates the patient personal information 122 with the captured image information 123 in the patient file 121.
The search mode is an operation mode performed after the storage mode. In the search mode, the OCT control apparatus 100 accepts an input of an operation for searching for image information from the outside, extracts desired image information 123 from the patient file 121 stored in the storage unit 120, and displays it on the display device 54. .

<Overview of stereoscopic scanning>
A procedure in which the OCT control apparatus 100 generates a two-dimensional OCT image and further performs a stereoscopic scan will be described with reference to FIGS. 5 and 6 (see FIG. 3 as appropriate).
The patient's teeth (sample S) are positioned in advance. Further, based on the user's operation, the scanning area selection control unit 143 determines the range to be scanned by the galvano mirror 33 from, for example, the ranges S, M, and L shown in FIG.

  The A line, the B line, and the V line shown in FIGS. 5A and 5B indicate directions along the A axis, the B axis, and the V axis of the diagnostic probe unit 30 shown in FIG. 4B. ing. 5A corresponds to data indicating tomographic information (internal information) in the depth direction from the surface of the sample S, and B line corresponds to data indicating internal information in the width direction of the sample S. To do. The V line shown in FIG. 5B corresponds to data indicating internal information of the sample S in the depth direction. If each data of A line, B line, and V line in a predetermined range is acquired, one volume of solid (3D) can be scanned.

  The OCT image generation means 152 of the image processing means 150 acquires A line data (step S1). The galvano mirror control circuit 53 appropriately changes the galvano mirror X and Y axes under the control of the scanning area selection control means 143 (step S2). An example of timing will be described later.

Then, the OCT image generation unit 152 determines whether or not one volume of A line data has been acquired (step S3) . When the A line data for one volume has not yet been acquired (step S3: No), the OCT image generation unit 152 returns to step S1. On the other hand, when one volume of A line data has been acquired (step S3: Yes), the OCT image generation unit 152 performs window processing (step S4). Subsequently, the OCT image generation unit 152 performs an FFT operation (step S5).

<Specific examples of stereoscopic scanning>
Hereinafter, a specific example of stereoscopic scanning will be described.
In the present embodiment, for example, A line data of 1152 points is acquired. In this case, assuming a cubic virtual space (one side L) aligned with the position of the sample S positioned at the nozzle tip of the diagnostic probe unit 30, the 0th point indicating the nozzle-side outermost surface of the virtual space has a waveform. 1152 point A line data is acquired with the 1151st point indicating the data start point and the outermost surface on the depth side of the virtual space as the end point of the waveform data. Note that each point does not indicate a depth position.

  Then, in order to minimize the influence due to the limited amount of recorded data, a window function is applied to the time domain measurement signal (window processing is performed). Thereby, a continuous waveform without a rapid transition is obtained.

  In order to perform frequency analysis (FFT processing) on the A-line data, and to smooth the shape of the spectrum after the FFT processing, zero suppression is performed on the A-line data of 1152 points and 2048 points. Data. That is, 896 points are added to A line data of 1152 points, and the amplitude of the waveform at each added point is treated as 0.

  Then, 1024 frequency components are obtained by performing frequency analysis (FFT processing) on the continuous waveform of 2048 points. As a result of frequency analysis, it is found that a reflector or scatterer exists at a shallow position when a low frequency component is included in the waveform data, and a deep position when a high frequency component is included in the waveform data. .

  When the Y-direction galvanometer mirror 33Y has a predetermined rotation angle, the axis of the X-direction galvanometer mirror 33X is slightly rotated to shift the laser irradiation position in the lateral direction (X-axis direction) along the B line. Get line data. This is repeated the same number of times as a predetermined number of points (for example, 128 points) for the B line, and a three-dimensional slice image (A, B line data) is acquired.

  Here, the stereoscopic slice image can be generated by converting the 1024 amplitude intensities of the A line into luminance values for 1024 pixels. When the luminance value is expressed by 12 bits, for example, it is a numerical value of 0 to 4095, and any one of 0 to 4095 may be assigned to 1024 amplitude intensities.

  Further, the axis of the Y-direction galvanometer mirror 33Y is slightly rotated, the laser irradiation position is shifted in the vertical direction (Y-axis direction) along the V line, and slice images (A and B line data) are acquired. Go. This is repeated the same number of times as a predetermined number of points (for example, 128 points) on the V line, and solid data is obtained.

  As a predetermined number of points for the B line and the V line, for example, 128 points can be selected during preview, and 200 points, 300 points, and 400 points can be selected during measurement.

<Onface image generation processing>
Here, the on-face image generation processing will be described with reference to FIG.
Since each process of step S11-S15 is the same as each process of step S1-S5, description is abbreviate | omitted. Subsequently, the on-face image generation unit 151 of the image processing unit 150 adds the A line data (step S16). Here, as a result of FFT processing of the A line data, for example, when 1024 frequency components are obtained, a sum total of all 1024 frequency components is obtained.

  Then, the on-face image generation means 151 averages the sum of the A line data (step S17). Here, for example, when 1024 frequency components are obtained, the sum of A line data is divided by 1024 to obtain an average value. The averaging process of the frequency components in steps S16 and S17 is performed on an image (B × V line data) of a two-dimensional plane formed by the width direction (B line) of the sample S and the depth direction (V line) of the sample S. This corresponds to a process for obtaining one pixel value (see FIGS. 5A and 5B).

  Then, the on-face image generation means 151 determines whether or not the frequency component averaging processing has been completed for the B × V line data (step S18). If the processing has not been completed for the B × V line data (step S18: No), the on-face image generation unit 151 returns to step S16. On the other hand, when the processing is completed for the B × V line data (step S18: Yes), the on-face image generation unit 151 ends the process. For example, during preview, an on-face image with a resolution of 128 × 128 pixels is generated. Further, for example, when measuring 400 × 400, an on-face image having a resolution of 400 × 400 pixels is generated.

<Specific example of image processing timing>
Here, a specific example of image processing timing will be described with reference to FIG.
FIG. 8 is an example of a timing chart of image processing by the OCT control apparatus 100 according to the embodiment of the present invention.
FIG. 8A shows a scanning trigger (trigger: see FIG. 2) output from the light source 11.
FIG. 8B shows a start trigger (analog output) output from the DA conversion circuit 52, and has the same pulse waveform as that in FIG.
FIG. 8C shows the analog output voltage in the X direction output from the galvano mirror control circuit 53 to the X direction galvano mirror 33X.
FIG. 8D shows the analog output voltage in the Y direction output from the galvano mirror control circuit 53 to the Y direction galvano mirror 33Y.
FIG. 8E shows a clock (ck: see FIG. 2) output from the light source 11 for generating an OCT image.

  In this example, the sweep speed of the light source 11 is 50 kHz, and in synchronization with this, slight movement (rotation) and stop of the axis of the X-direction galvanometer mirror 33X are repeatedly performed at 50 kHz (pulse period 20 us). did. Note that us represents microseconds.

Preview or measurement is started at time S shown in FIG.
Waiting for a period of 15 pulses after the start, stereoscopic scanning starts at the time A shown in FIG. 8A, and one volume stereoscopic scanning ends at the time B shown in FIG. 8A. To do. At the time of measurement, the measurement ends at time B. At the time of preview, the process is repeated after returning to the time A after the time B.

  As shown in FIG. 8C, the analog output voltage in the X direction is −Vx at the time of A, becomes + Vx at the time of the 158th pulse from the time of A (mirror outward path), and then the 30th pulse. -Vx again at the time of (mirror return path). Thereafter, the processing is repeated until the one-dimensional stereoscopic scanning is completed.

  158 pulses shown in FIG. 8C correspond to 128 points on the B line. The reason why 158 points of data are acquired by 30 points more than the required 128 points is as follows. That is, since the amount of change in position at both ends where the galvano mirror 33 is at the maximum swing angle is very small, the data at 15 points at both ends cannot be put to practical use.

  Note that when measuring 200 points on the B line, it becomes + Vx at the time of the 230th pulse, at time of the 330th pulse when measuring 300 points, and at the time of the 430th pulse when measuring 400 points.

  Also, the reason why the mirror return path is moved in a shorter time than the mirror return path is because data on the mirror return path is not used. At this time, the operating speed of the galvanometer mirror 33 is limited (for example, a maximum of 100 Hz for oscillating ± 30 °), and therefore it is necessary to return the galvanometer mirror 33 at such a speed as not to break.

  As shown in FIG. 8D, the analog output voltage in the Y direction is −Vy from the time A to the time of the 158th pulse, and slightly changes at the 159th pulse (after the B line scan). Similarly, it slightly changes after the B-line scan, and becomes + Vy (mirror forward) at a predetermined time before the time when the one-dimensional stereoscopic scan is finished (30 pulses before time B), and then again at the time of the 30th pulse. -Vy (mirror return).

  As shown in FIG. 8E, in order to generate an image, data is sampled at 50 kHz (pulse period 20 us) from time A to time B. Then, for example, a slice image of the first frame is generated in a 128-pulse period in the mirror forward path (158 pulse period) from time A (imaging (first frame)). As described above, the acquired data for the period of 15 pulses before and after is not used. Similarly, a slice image of each frame is generated when scanning the B line. In this example, a 128-frame slice image is generated as V-line data.

[4. Screen display example of display device]
<Online screen>
Here, a specific example of the online screen will be described with reference to FIG.
In this online screen, a 3D screen arranged on the left side of FIG. 9, an on-face screen arranged on the lower center side of FIG. 9, and an OCT screen arranged on the upper center side of FIG. 9 are displayed as image information.

  In the example illustrated in FIG. 9, a virtual space of a cube is assumed in accordance with the position of the sample S (molar tooth) positioned at the nozzle tip of the diagnostic probe unit 30. For example, on an on-face screen, each surface of the cube is represented by an S-plane (on-face image sample S surface: upper surface), an A-plane (front surface viewed from the on-face image sample S-plane), and a P-plane (on-face image sample S). Rear surface viewed from the surface), R surface (right side when looking forward from the sample S surface of the Onface image), L surface (left side when looking forward from the Sample S surface of the Onface image), I surface ( The opposite surface of the sample S surface of the on-face image: the lower surface).

  The on-face screen displays an on-face image in which information on the surface of the sample S viewed from the S-plane (sample S-plane of the on-face image) and information on the depth direction of the sample S are combined. On-face images also show internal information that is not originally visible on the outer surface.

  The OCT screen is a plane parallel to the A plane (the front surface as viewed from the sample S surface of the Onface image), and is an OCT image of a cut surface (tomographic plane) cut by a line 901 indicated by a horizontal line arranged in the Onface image. Is displayed. In the example of FIG. 9, an image of the tomographic plane in the direction of viewing the P plane from the A plane is displayed as an OCT image. Conversely, an image of a tomographic plane in the direction of viewing the A plane from the P plane may be displayed as an OCT image. The line 901 can be moved by an operation on a GUI (graphical user interface). Specifically, the slider 902 displayed as a bar between the Onface screen and the OCT screen can be moved by dragging and dropping with, for example, a mouse (input device M). That is, by moving the mouse while pressing the mouse button, the slider 902 is moved, and when the operation of the slider 902 is terminated by releasing the mouse button, the mouse button is released. The OCT image on the tomographic plane corresponding to the position of the line on the on-face screen is displayed on the OCT screen. Alternatively, the line 901 itself can be moved by dragging and dropping with a mouse, and a tomographic plane corresponding to the position of the line can be displayed. Since the on-face image is a monochrome image, it is preferable to display the lines on the on-face screen in red or the like.

The 3D screen designates the A, P, S, I, R, and L planes of “Camera Angle” on the right side of the online screen, thereby displaying a stereoscopic image viewed from a desired plane in real time. The illustrated example is a front left image of the sample S viewed from the S plane (sample S plane of the on-face image). The line 901 displayed on the 3D screen is synchronized with the line 901 displayed on the on-face image. That is, the tomography on the line 901 displayed on the 3D screen is displayed on the OCT screen (screen on the A plane). When the line 901 displayed on the 3D screen is moved by dragging and dropping with the mouse, the OCT image displayed on the OCT screen (screen on the A side) changes.
Further, the tomographic image on the line 901 of the 3D screen can be displayed as it is on the 3D screen. This is because the data on the A plane side is deleted from the tomographic plane (cut plane) along the line 901 in a state where the sample S is cut on the line 901 on the 3D screen, and the OCT image of the cut plane and the remaining P It corresponds to what is displayed in combination with the 3D image of the surface side portion.

Various information such as patient personal information is displayed on the left side of the upper part of the online screen.
On the upper right side of the online screen, “Preview”, “Measure”, “400 × 400”, “ZeroAdj”, “Save”, “Setting”, “Exit”, and the like are arranged as operation buttons.

  “Preview” indicates a button for inputting a preview instruction. When this button is pressed, the respective images are displayed in real time on the 3D screen, the on-face screen, and the OCT screen. For example, the 3D image is updated approximately every 1 second. If the nozzle tip of the diagnostic probe unit 30 is moved, the image information (preview image) that follows it can be acquired. Note that the preview image is not premised on storage.

  “Measure” indicates a button for inputting a measurement instruction. When the “Measure” button is pressed during the preview, the preview instruction is canceled and the main shooting is started. The shooting is automatically completed at the shooting time corresponding to the resolution selected at that time. The main photographing is photographing premised on preservation, and is performed with the sample S fixed. Here, “fixed” means that the nozzle tip of the diagnostic probe unit 30 is brought into contact with the sample S. At this time, for example, the patient may stay still. In the case of a resolution of “400 × 400”, the main shooting is completed in about 3 seconds, and when the resolution is lower than that, the shooting is completed in less than 3 seconds.

  “400 × 400” indicates a button for inputting a resolution. This button is “128 × 128” during preview. When the button is pressed before measurement, one of resolutions “200 × 200”, “300 × 300”, and “400 × 400” can be selected from the pull-down menu.

  “ZeroAdj” is used to perform initialization zero point correction in which the shutter 31 (see FIG. 2) of the diagnostic probe unit 30 is closed and noise of the optical system is measured as background data during calibration before data recording. Indicates a button. The OCT image generation unit 152 reduces the influence of noise by subtracting background data from recorded data during data scanning. If it is performed at the time of preview, it is not necessary to perform it at the time of measurement.

  “Save” indicates a button for saving scanned data as binary data at the time of measurement. The data stored here can be read and displayed on an offline screen described later. Before the preview, a patient file 121 (see FIG. 3) is created and patient personal information 122 is input. The patient personal information includes the tooth number of the part to be imaged in addition to the name and the like. On the premise of this prior input, the “Save” button can be pressed to associate the corresponding image information 123 with the patient file 121 (see FIG. 3).

  When a measurement instruction is input to the imaging control unit 140 by the foot controller 80, the screen of the display device 54 transitions to a screen (screen of the save operation page) displayed when the “Save” button is pressed after the main imaging is completed. To do. Then, on the screen of the save operation page, a message inquiring to save the captured image information, and a “Yes” button and a “No” button are displayed. When the user depresses the pedal of the foot controller 80 by one step, either “Yes” or “No” is selected. Here, for example, when “Yes” is selected, when the user depresses the pedal of the foot controller 80 by another step, that is, a total of two steps, the image information storage instruction is fixed.

If the user first depresses the pedal by one step and releases his / her foot when “Yes” is selected, the pedal returns to the original position and the current selection “Yes” is not confirmed. When the user depresses the pedal of the foot controller 80 again by one step, the display is changed to “No”. Hereinafter, similarly, “Yes” and “No” before confirmation can be switched.
When the parallel system is adopted instead of the two-step depression system, the user depresses each foot switch corresponding to “Yes” and “No”. Here, each of the foot switches corresponding to “Yes” and “No” can also function as a switch that outputs the first and second switch signals, but a dedicated foot switch is used for the foot controller 80. It may be provided separately.

  “Setting” indicates a button for inputting a range to be scanned by the galvanometer mirror 33. When this button is pressed, one of three areas S, M, and L can be selected from the pull-down menu. Based on the operation data input at this time, the scanning area selection control unit 143 (see FIG. 3) determines a range to be scanned by the galvanometer mirror 33.

  “Exit” indicates a button for exiting the online screen and returning to the previous screen or the top screen.

On the right side of the online screen, a slider for adjusting the settings of the 3D screen, all screen displays, images displayed on the A screen, and the like is displayed as a bar.
“Window Width” is a bar for determining the adjustment range of contrast.
“Window Level” is a bar for determining the median value of Window Width.
“Gamma” is a bar for emphasizing weak signals so that the contrast can be adjusted. In the example shown in the figure, a state in which “3D screen” is designated and adjustment is performed using the lower slider is shown.

<Offline screen>
Here, a specific example of the offline screen will be described with reference to FIG.
The OCT screen arranged at the upper left center of FIG. 10 shows a tomographic image cut along a cross section parallel to the S plane (sample S plane of the on-face image). By moving the slider displayed on the lower side of the OCT screen, an image parallel to the scan plane corresponding to any depth position of the A line (1024-point FFT) (any of 1024 images) Can be displayed.
The OCT screen arranged at the lower left center of FIG. 10 shows a tomographic image cut by a cross section parallel to the A plane. By moving a slider displayed as a bar on the lower side of the OCT screen, a slice image (A, B line data) corresponding to any position of the V line (400 points) can be displayed.
The OCT screen arranged at the upper right corner of FIG. 10 shows a tomographic image cut by a cross section parallel to the L plane. By moving the slider displayed on the lower side of the OCT screen, a slice image (A, V line data) corresponding to any position of the B line (400 points) can be displayed.
The on-face screen arranged in the lower right center of FIG. 10 displays an on-face image viewed from the S plane (sample S plane of the on-face image).

On the left side of FIG. 10, a 3D screen rendered from saved data is displayed. On this 3D screen, three lines that can be moved by an operation on the GUI are displayed. Line 901 is similar to line 901 shown in FIG. That is, the cross-sectional tomographic position is perpendicular to the direction from the A plane to the P plane. This cross section corresponds to the OCT screen (A surface) arranged at the lower left center of FIG.
The line 1001 is orthogonal to the line 901 when viewed from the S plane (the sample S plane of the Onface image). That is, the cross-sectional tomographic position is perpendicular to the direction from the L plane to the R plane. This cross section corresponds to the OCT screen (L plane) arranged at the upper right of the center of FIG. The direction from the R plane to the L plane may be used.
The line 1002 is a straight line at a position rotated by 45 degrees from the line 901 and the line 1001 when viewed from the S plane (sample S plane of the on-face image). Although the screen about this cross section is omitted in FIG. 10, it is a known tomographic display surface used in CT (Computed Tomography) or the like.
A tomographic image of a corresponding screen (A screen, L screen, etc.) is displayed by moving these three lines (901, 1001, 1002) on the 3D screen.

On the left side of the upper part of the offline screen, various information such as patient personal information is displayed.
In the center of the off-line the top of the screen, shooting date and shooting sites are displayed.
On the right side of the upper part of the offline screen, “Export”, “Exit” and the like are arranged as operation buttons.
“Export” indicates a button for converting and outputting image data.
“Exit” indicates a button for exiting the offline screen and returning to the previous screen or the top screen.

  According to the present embodiment, the OCT control apparatus 100 displays a low resolution OCT image in the preview mode and displays a high resolution OCT image in the measurement mode. Therefore, for example, an OCT image used for measurement or diagnosis can be acquired in advance in a preview mode with a coarse resolution. Further, in the preview mode, the OCT image that has been photographed and processed can be displayed as a real-time moving image, so that different resolution OCT images can be easily displayed repeatedly. Accordingly, the user can quickly find a desired tomographic plane as an image of the tomographic plane of the sample S, and can acquire a high-resolution desired tomographic image of the sample S at high speed using the information.

  As mentioned above, although embodiment of this invention was described, this invention is not limited to this, It can implement in the range which does not change the meaning. For example, in the preview mode, the OCT control apparatus 100 starts imaging when it is determined that an input of a preview instruction is received from the outside, and ends imaging when it is determined that an input of a measurement instruction is received. Of course, a preview instruction cancel instruction may be issued separately from the measurement instruction input.

Further, the present invention is not limited to the performance of the laser used in the light source 11 as a highly coherent one having a coherence distance (coherent length) of 10 mm or more.
Moreover, although this embodiment demonstrated using SS-OCT system, you may use SD-OCT and TD-OCT.
4B, the nozzle tip shown in FIG. 4B is preferably used when the sample S is an anterior tooth. When the sample S is a molar, a member capable of reflecting laser light at a right angle is used. It is preferable to attach to the nozzle tip.
In the present invention, the subject is not limited to a tooth. Further, the present invention may be applied to medical equipment other than dentistry, non-destructive inspection, and the like.

1,1A OCT device (optical coherence tomographic image generator)
10 Optical unit (optical unit)
DESCRIPTION OF SYMBOLS 11 Light source 12 Coupler 13 Sample arm 14 Circulator 15 Polarization controller 16 Coupler 17 Reference arm 18 Circulator 19 Collimator lens 20 Condensing lens 21 Reference mirror 22 Polarization controller 23 Detector (detector)
30 Diagnostic probe section (probe)
31 Shutter 32 Collimator lens 33 Galvano mirror (scanning mechanism)
33X X direction galvanometer mirror 33Y Y direction galvanometer mirror 34 Condensing lens 50 Control unit (control unit)
51 AD conversion circuit 52 DA conversion circuit 53 Galvano mirror control circuit 54 Display device 60 Cable 70 Single joint arm 70A Articulated arm 80 Foot controller 100 OCT control device 110 Input / output means 120 Storage means 121 Patient file 122 Patient personal information 123 Image information DESCRIPTION OF SYMBOLS 130 Calculation means 140 Imaging | photography control means 141 1st imaging | photography control means 142 2nd imaging | photography control means 143 Scanning area selection control means 150 Image processing means 151 On-face image generation means 152 OCT image generation means 153 Rendering means 154 Tomographic position line generation means 160 File Creation processing means M Input device S Sample (subject)

Claims (7)

An optical unit that includes a light source that periodically irradiates a subject with laser light and a detector that detects internal information of the subject, and a scanning mechanism that two-dimensionally scans the laser light. A probe that guides light reflected by the subject to the optical unit and a probe that guides the light reflected by the subject to the optical unit, and controls the scanning mechanism in synchronization with the laser light to perform imaging and convert the detection signal of the detector from the data A control device that performs control to generate an optical coherence tomographic image of a subject and a control unit that includes a display device that displays the optical coherence tomographic image, the control device of an optical coherence tomographic image generation device comprising:
Shooting control means for shooting in a predetermined shooting mode based on an external input;
Image processing means for image processing the detection signal acquired by photographing;
With
The image processing means includes
As a two-dimensional image of the scan plane in the direction perpendicular to the optical axis of the subject, an image in which information on the surface of the subject irradiated with the laser light and information on the direction along the optical axis in the subject are combined. and omphacite image generating means for generating omphacite image is a two-dimensional image obtained by summing the depth direction of the data of the three-dimensional image of the object I Oh,
A tomographic position line generation unit that draws and superimposes the tomographic position of the optical coherence tomographic image in a line on the on-face image displayed on the display device;
An instruction to select and move the line of the tomographic position displayed on the display device is received, and the optical coherence tomographic image is generated from data obtained by converting the detection signal of the detector based on the information of the selected and moved line Optical coherence tomographic image generating means for
Equipped with a,
The on-face image generated by performing image processing on the information acquired by the probe in an imaging mode not premised on the storage of detection signal data obtained by imaging, and the light at the tomographic position specified by the line on the on-face image An apparatus for controlling an optical coherence tomographic image generation apparatus, wherein the coherence tomographic image is displayed on the display device as a real-time image . The on-face image generation means generates a 3D image of the subject in the process of generating the on-face image,
The tomographic position line generation means draws the tomographic position of the optical coherent tomographic image in a line on the 3D image of the subject displayed on the display device in synchronization with the line displayed on the on-face image. Superimposed,
The optical coherent tomographic image generation means receives an instruction to select and move the line at the tomographic position in the 3D image displayed on the display device, and based on the information on the selected and moved line, the detector The optical coherence tomographic image is generated from data obtained by converting a detection signal, and is superimposed on a tomographic plane along the line of the 3D image exposed by cutting out the 3D image. The control apparatus of the optical coherence tomographic image generation apparatus of description. The image processing means includes
The apparatus further comprises: rendering means for rendering a 3D image of the subject by rendering from the data stored in the storage means as data obtained by converting the detection signal of the detector when the subject is photographed. The control apparatus of the optical coherence tomographic image generation apparatus of Claim 1 or Claim 2. The photographing control means includes
Shooting is started when it is determined that the scanning mechanism has received an input of a measurement instruction for scanning the shooting target range of the subject at a predetermined pitch in order to measure internal information of the subject, and a shooting time corresponding to the predetermined pitch First shooting control means for ending shooting at;
When it is determined that an input of a preview instruction for allowing the scanning mechanism to scan the imaging target range at a pitch coarser than the predetermined pitch is received, and an input of an instruction for canceling the preview instruction is received. Second shooting control means for ending shooting at the same time;
The control apparatus for an optical coherence tomographic image generation apparatus according to any one of claims 1 to 3, further comprising:   The control unit includes a foot controller that is communicably connected to the photographing control unit in a wired or wireless manner. The foot controller includes a first switch and a second switch, and a user can use his / her foot. When the first switch or the second switch is operated, the first switch signal or the second switch signal is notified to the photographing control unit corresponding to any one of the switches, and the second switch The imaging control means determines that the input of the preview instruction is received when receiving the input of the first switch signal from the foot controller, and the preview instruction when receiving the input of the second switch signal. The first photographing control means determines that the input of an instruction to cancel the image is received, and the first photographing control means receives the second switch from the foot controller. Upon receiving an input of the switch signal, the control apparatus for an optical interference tomographic image generating apparatus according to claim 4, characterized in that to determine that accepts the input of the measurement instruction. An optical unit that includes a light source that periodically irradiates a subject with laser light and a detector that detects internal information of the subject, and a scanning mechanism that two-dimensionally scans the laser light. A probe that guides light reflected by the subject to the optical unit and a probe that guides the light reflected by the subject to the optical unit, and controls the scanning mechanism in synchronization with the laser light to perform imaging and convert the detection signal of the detector from the data A control method of an optical coherence tomographic image generation apparatus comprising: a control device that performs control to generate an optical coherence tomographic image of a subject; and a control unit that includes a display device that displays the optical coherence tomographic image,
The controller is
A step of shooting in a predetermined shooting mode based on an external input;
An image processing step of performing image processing on the detection signal acquired by photographing,
The image processing step includes
As a two-dimensional image of the scan plane in the direction perpendicular to the optical axis of the subject, an image in which information on the surface of the subject irradiated with the laser light and information on the direction along the optical axis in the subject are combined. and omphacite picture generating step of generating omphacite images are two-dimensional image obtained by summing the data in the depth direction of the 3-dimensional image of the object I Oh,
A tomographic position line generation step of drawing and superimposing a tomographic position of the optical coherence tomographic image in a line on the on-face image displayed on the display device;
An instruction to select and move the line of the tomographic position displayed on the display device is received, and the optical coherence tomographic image is generated from data obtained by converting the detection signal of the detector based on the information of the selected and moved line Optical coherence tomographic image generation step,
I have a,
The on-face image generated by performing image processing on the information acquired by the probe in an imaging mode not premised on the storage of detection signal data obtained by imaging, and the light at the tomographic position specified by the line on the on-face image A method for controlling an optical coherence tomographic image generation apparatus, comprising displaying an coherent tomographic image on the display device as a real-time image .   An optical coherence tomographic image generation device control program for causing a computer to function as each means of the control device of the optical coherence tomographic image generation device according to any one of claims 1 to 5.

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