JP5701314B2 - 中心から段階的に配置されたチャンバを有するマルチユニット血液プロセッサ - Google Patents
中心から段階的に配置されたチャンバを有するマルチユニット血液プロセッサ Download PDFInfo
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- JP5701314B2 JP5701314B2 JP2012543121A JP2012543121A JP5701314B2 JP 5701314 B2 JP5701314 B2 JP 5701314B2 JP 2012543121 A JP2012543121 A JP 2012543121A JP 2012543121 A JP2012543121 A JP 2012543121A JP 5701314 B2 JP5701314 B2 JP 5701314B2
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- bag
- separation
- component
- tube
- rotor
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004369 blood Anatomy 0.000 title description 36
- 239000008280 blood Substances 0.000 title description 36
- 238000000926 separation method Methods 0.000 claims description 108
- 239000007788 liquid Substances 0.000 claims description 20
- 239000002131 composite material Substances 0.000 claims description 14
- 238000012545 processing Methods 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 claims description 2
- 239000000306 component Substances 0.000 description 86
- 210000004027 cell Anatomy 0.000 description 35
- 239000012530 fluid Substances 0.000 description 31
- 210000003743 erythrocyte Anatomy 0.000 description 18
- 210000001772 blood platelet Anatomy 0.000 description 14
- 239000012503 blood component Substances 0.000 description 13
- 238000012546 transfer Methods 0.000 description 13
- 238000000034 method Methods 0.000 description 11
- 238000004140 cleaning Methods 0.000 description 10
- 238000005534 hematocrit Methods 0.000 description 8
- 239000002699 waste material Substances 0.000 description 7
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000003466 welding Methods 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 4
- 210000000601 blood cell Anatomy 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 206010033307 Overweight Diseases 0.000 description 2
- 102000029797 Prion Human genes 0.000 description 2
- 108091000054 Prion Proteins 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 210000004180 plasmocyte Anatomy 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 241000239290 Araneae Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
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- 230000017531 blood circulation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
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- 239000000725 suspension Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
- B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
- A61M2202/0437—Blood stem cells
Description
Claims (7)
- 少なくとも2つの体積に分けられた複合液体を少なくとも第1の成分と第2の成分とに分離する装置であって、
回転軸(68)を中心として回転するように適合された遠心分離機ロータ(64)と、
少なくとも1つの成分バッグ(14、16)と少なくとも1つの補助バッグ(44)とを有するバッグ(14、16、44)セットに流体的に相互接続され且つある体積の複合液体を含む分離バッグ(12)を受容するように適合された複数の分離セル(78)と、
前記少なくとも1つの成分バッグ(14、16)を受容する複数のキャビティ(154)と、
前記バッグ(14、16)に接続するチューブ(18、32、36、46)と係合するように適合された複数の弁(128、130、132)と、
少なくとも1つの前記補助バッグ(44)を受容する複数のウェル部(156)と、
を備え、
前記複数の分離セル(78)は、高遠心力領域内において前記回転軸(68)から半径方向外側に配置され、
前記複数のキャビティ(154)は、中間遠心力領域において、前記回転軸(68)から半径方向外側に且つ前記複数の分離セル(78)から半径方向内側に配置され、
前記複数の弁(128、130、132)は、前記キャビティ(154)から半径方向内側に配置され、
前記複数のウェル部(156)は、前記複数のキャビティ(154)の位置に対する低遠心力領域において、前記回転軸(68)から半径方向外側に且つ前記複数のキャビティ(154)から半径方向内側に配置され、
前記複数の分離セル(78)のうちの1つ、前記複数のキャビティ(154)のうちの1つ、及び前記複数のウェル部(156)のうちの1つは、チューブ接続されたバッグセットを受容する処理セットとして、互いに関連づけられることを特徴とする装置。 - 請求項1記載の装置において、前記ウェル部は、前記弁のうち少なくともいくつかの弁よりも前記回転軸へより近接していることを特徴とする装置。
- 請求項1記載の装置において、前記ウェル部は矩形であることを特徴とする装置。
- 請求項1記載の装置において、前記ウェル部は円筒形であることを特徴とする装置。
- 請求項1記載の装置において、前記処理セットは、前記回転軸を中心として対称に配置されることを特徴とする装置。
- 請求項5記載の装置において、前記ロータは、半径方向に延在する支持アームによって支持されたコアを備え、前記支持アームは、分離セルと、隣接する1組の弁との間にキャビティを規定することを特徴とする装置。
- 請求項6記載の装置において、前記ウェル部は、前記コアに配置されることを特徴とする装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26748909P | 2009-12-08 | 2009-12-08 | |
US61/267,489 | 2009-12-08 | ||
PCT/US2010/056098 WO2011071643A1 (en) | 2009-12-08 | 2010-11-10 | Multi-unit blood processor with progressively centered chambers |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013512759A JP2013512759A (ja) | 2013-04-18 |
JP5701314B2 true JP5701314B2 (ja) | 2015-04-15 |
Family
ID=43414759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012543121A Active JP5701314B2 (ja) | 2009-12-08 | 2010-12-03 | 中心から段階的に配置されたチャンバを有するマルチユニット血液プロセッサ |
Country Status (7)
Country | Link |
---|---|
US (1) | US20110136650A1 (ja) |
EP (1) | EP2509655B1 (ja) |
JP (1) | JP5701314B2 (ja) |
CN (1) | CN102655895B (ja) |
ES (1) | ES2473970T3 (ja) |
RU (1) | RU2553383C2 (ja) |
WO (1) | WO2011071643A1 (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9327296B2 (en) | 2012-01-27 | 2016-05-03 | Fenwal, Inc. | Fluid separation chambers for fluid processing systems |
AU2013337284B2 (en) * | 2012-11-05 | 2018-03-08 | Haemonetics Corporation | Continuous flow separation chamber |
US8803090B2 (en) | 2012-11-09 | 2014-08-12 | Fenwal, Inc. | Citrate detector for blood processing system |
US10258927B2 (en) | 2012-12-14 | 2019-04-16 | Chong Zheng | Centrifugal dynamic filtering apparatus and cell separation system using same |
JP5925962B2 (ja) * | 2012-12-14 | 2016-05-25 | 鄭▲ちゅう▼ZHENG Chong | 遠心動的濾過装置及びそれを用いた細胞分離システム |
US20160017287A1 (en) * | 2013-03-04 | 2016-01-21 | Swiss Stem Cell Foundation | System for extraction of cells from a sample of tissue |
DE202014101503U1 (de) * | 2014-03-31 | 2015-07-06 | Grass Gmbh & Co. Kg | Vorrichtung zur Bewegungsdämpfung |
WO2016134317A1 (en) * | 2015-02-20 | 2016-08-25 | Terumo Bct, Inc. | Composite liquid bag system holder |
EP3124063B1 (en) | 2015-07-29 | 2019-04-10 | Fenwal, Inc. | Five-port blood separation chamber and methods of using the same |
WO2018102823A1 (en) | 2016-12-02 | 2018-06-07 | Terumo Bct, Inc | Composite fluid separation |
IT201700105911A1 (it) * | 2017-09-21 | 2019-03-21 | Menarini Silicon Biosystems Spa | Metodo ed apparato per la riduzione del volume di un campione |
WO2020006418A2 (en) * | 2018-06-29 | 2020-01-02 | Terumo Bct, Inc | Composite fluid bag system holder |
JP6805393B1 (ja) * | 2019-03-19 | 2020-12-23 | テルモ株式会社 | 血液バッグシステム |
CN115025892B (zh) * | 2022-05-10 | 2023-10-24 | 深圳市普康电子有限公司 | 一种血液检测的离心装置 |
Family Cites Families (14)
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SE319326B (ja) * | 1964-01-03 | 1970-01-12 | H Unger | |
JPS50107565A (ja) * | 1974-01-29 | 1975-08-25 | ||
DE2408206A1 (de) * | 1974-02-21 | 1975-09-04 | Heraeus Christ Gmbh | Behaelter fuer biologische fluessigkeiten zum einsatz in zentrifugen |
US4111355A (en) * | 1977-06-15 | 1978-09-05 | Beckman Instruments, Inc. | Multi-compartment centrifuge rotor liner |
SU1123726A1 (ru) * | 1983-01-24 | 1984-11-15 | Специальное Конструкторское Бюро Биофизической Аппаратуры | Устройство дл обработки крови |
SE9700495D0 (sv) * | 1997-02-12 | 1997-02-12 | Omega Medicinteknik Ab | Metod och rundpåsesystem samt centrifug för behandling av blod |
US20020020680A1 (en) * | 2000-06-20 | 2002-02-21 | Glen Jorgensen | Blood component preparation (BCP) device and method of use thereof |
WO2001097943A1 (en) * | 2000-06-20 | 2001-12-27 | Medicept, Inc. | Blood component preparation (bcp) device and method of use thereof |
AU2002230652A1 (en) * | 2000-11-02 | 2002-05-15 | Gambro, Inc | Fluid separation devices, systems and methods |
AU2006262692B2 (en) * | 2005-06-22 | 2010-12-09 | Caridianbct, Inc. | Apparatus and method for separating discrete volumes of a composite liquid |
US8173027B2 (en) * | 2006-09-06 | 2012-05-08 | Terumo Bct, Inc. | Method of separating a composite liquid into at least two components |
EP2077871A2 (en) * | 2006-10-20 | 2009-07-15 | CaridianBCT Biotechnologies, LLC | Methods for washing a red blood cell component and for removing prions therefrom |
WO2008105972A1 (en) * | 2007-02-26 | 2008-09-04 | Caridianbct, Inc. | Apparatus for separating a composite liquid with process control on a centrifuge rotor |
RU67479U1 (ru) * | 2007-05-29 | 2007-10-27 | Открытое акционерное общество "Научно-исследовательский технологический институт "НИТИ-ТЕСАР" (ОАО "НИТИ-ТЕСАР") | Установка очистки жидкостей |
-
2010
- 2010-11-10 US US12/943,650 patent/US20110136650A1/en not_active Abandoned
- 2010-11-10 RU RU2012128518/14A patent/RU2553383C2/ru active
- 2010-11-10 WO PCT/US2010/056098 patent/WO2011071643A1/en active Application Filing
- 2010-11-10 CN CN201080055629.6A patent/CN102655895B/zh active Active
- 2010-11-10 EP EP10781764.5A patent/EP2509655B1/en active Active
- 2010-11-10 ES ES10781764.5T patent/ES2473970T3/es active Active
- 2010-12-03 JP JP2012543121A patent/JP5701314B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
JP2013512759A (ja) | 2013-04-18 |
EP2509655A1 (en) | 2012-10-17 |
WO2011071643A1 (en) | 2011-06-16 |
CN102655895B (zh) | 2015-05-13 |
ES2473970T3 (es) | 2014-07-08 |
RU2553383C2 (ru) | 2015-06-10 |
CN102655895A (zh) | 2012-09-05 |
RU2012128518A (ru) | 2014-01-20 |
US20110136650A1 (en) | 2011-06-09 |
EP2509655B1 (en) | 2014-05-07 |
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