JP5644001B2 - Compact high-temperature high-pressure water microreactor - Google Patents

Description

  The present invention relates to a high-temperature / high-pressure water microreactor apparatus, and more particularly to a new compact high-temperature / high-pressure water microreactor that realizes downsizing a large-sized high-temperature / high-pressure water reactor. The present invention provides an ultra-compact high-temperature high-pressure water microreactor that can be suitably used for a chemical synthesis method using high-temperature high-pressure water containing supercritical water.

  Conventionally, various organic reaction examples for synthesizing various organic compounds using high-temperature and high-pressure water such as supercritical water have been reported. For example, using supercritical water, ε-caprolactam, propanol, pinacolone or pinacholine , Alcohol and carboxylic acid, cyclohexane, benzoic acid, phenol, amino acid (β-alanine, etc.), acrolein, amide (N-acylation), nitro compound, halide dehalogenated compound, olefin cyclized compound, etc. Has been proposed (Patent Documents 1 to 10).

  Many of these organic reaction examples are carried out by a batch method using a conventional large-sized high-temperature high-pressure water reactor. For example, the number of synthesis steps is large, and there is a barrier to cost reduction. In addition, there are problems such as difficulty in stable supply, much time for synthesis, precise reaction control, suppression of side reactions, and low-volume production of various products. Was strongly requested.

JP 2009-063422 A JP 2009-062341 A JP 2008-292018 A JP 2009-132663 A JP 2008-255015 A JP 2008-128255 A JP 2007-330964 A Japanese Patent Application Laid-Open No. 2007-291096 JP 2007-297338 A JP 2007-269766 A

  Under such circumstances, the present inventors have considered 1) precise reaction control, suppression of side reactions, 2) reduction of catalysts (noble metals, etc.), omission of protective group modification, interface As a result of intensive research aimed at developing a new compact continuous synthesizer capable of reducing the active agent, simplifying the separation, 3) building an environment-friendly high-efficiency process, etc. The present inventors have succeeded in developing a small continuous synthesizer using a reaction field, and have completed the present invention.

  An object of the present invention is to provide a small continuous synthesizer using a high-temperature and high-pressure water microreactor reaction field. In addition, the present invention makes it possible to achieve precise reaction control, suppression of side reactions, reduction of catalysts (noble metals, etc.), omission of protective group modification, reduction of surfactants, simplification of separation, and the like. An object of the present invention is to provide a new ultra-compact high-temperature high-pressure water microreactor that enables construction of an environment-friendly and highly efficient process. Another object of the present invention is to provide a continuous, high-temperature, high-pressure water microreactor that is a power-saving desktop factory that enables on-side on-demand production and production of high-value-added, small-quantity, multi-product substances. It is what.

The present invention for solving the above-described problems comprises the following technical means.
(1) Super high-speed heating / cooling of 0 to 1 second or less is possible. It is packaged in a package of 1 m ³ or less with a built-in microreactor. Power consumption is 2000 Wh or less. A compact high-temperature high-pressure water microreactor that can be used for organic reactions that synthesize organic compounds using high-temperature and high-pressure water containing critical water,
Reaction unit composed of a liquid feeding unit, a mixing unit, a heating unit, and a microreactor for cooling, for high-temperature and high-pressure water feeding, for substrate feeding, and for catalyst feeding, to be applied to a reaction system using an aqueous medium, cooling Part, further having an operation control part,
A plurality of microreactors can communicate with each other, and 1) a microreactor unit comprising a microreaction tube formed by superposing and forming a tube-like groove having a micro-size channel diameter on the surface of a substrate, or 2) It is composed of a microreactor unit consisting of a tube coil in which a groove is formed on the surface of the microtube and a coiled heater is wound around the groove.
The microreactor unit comprising the microreactor tube of 1) above is placed in a state where it can be heated in contact with the heating unit, and each microreactor unit can be heated by the respective heating unit in contact with them. Or it is installed variably in a part,
The microreactor unit composed of the tube coil of 2) is arranged so that the heating temperature of each tube coil can be changed by changing the heating temperature condition of each coil-shaped heater,
A compact high-temperature and high-pressure water microreactor characterized by having a modular structure with the microreactor unit as a basic unit.
(2) The above-mentioned microreactor is formed by connecting a plurality of microreactor units composed of microreaction tubes formed by forming tube-like grooves having a micro-size channel diameter on the surface of the base material and overlapping them. The compact high-temperature high-pressure water microreactor according to (1), which has a configuration and a structure in which a flow path length is adjustable.
(3) The whole or part of the microreactor is configured to be heated by a heating unit that is installed so as to be capable of being heated with respect to the microreactor and in which the heating temperature condition can be set to be variable in part or in part. ) Or the small high-temperature high-pressure water microreactor according to (2).
(4) The compact high-temperature and high-pressure water microreactor according to (1), wherein the ultrafast heating / cooling is ultrafast heating / cooling of 0.01 seconds or less.
(5) The small-sized high-temperature / high-pressure water microreactor according to (1), wherein the operation control unit includes a notebook PC.
(6) The small-sized high-temperature / high-pressure water microreactor according to (1), wherein the cooling unit includes an air-cooled cooler.
(7) The small-sized high-temperature / high-pressure water microreactor according to (1), wherein the mixing unit is composed of a micromixer.
(8) The small high-temperature high-pressure water microreactor according to (1), wherein the pump in the liquid feeding part is a syringe pump or a reciprocating pump.

Next, the present invention will be described in more detail.
The small high-temperature high-pressure water microreactor of the present invention is composed of a liquid feeding part, a mixing part, a heating part, a reaction part composed of a microreactor, a cooling part, a pressure control part, and an operation control part of the apparatus, These are packaged in a compact package of 1 m ³ or less, can be operated by obtaining power from a household 100V outlet, and are characterized by power consumption of 2000 Wh or less. The compact size, power source, and power consumption can be appropriately designed and changed within the same range.

  The specification example and the production example of the compact high-temperature high-pressure water microreactor of the present invention will be described. As an outline of the apparatus, the apparatus comprises a reaction unit composed of three pumps, a heating unit, and a microreactor, a cooling unit, a pressure This is a compact high-temperature / high-pressure water micro apparatus in which the controller and the operation control unit of the apparatus are all housed in one unit, and the size is exemplified by a compact apparatus of W500 × H350 × D450. Display and control of each part can be done with a notebook computer. It is preferable that the three pumps have a structure that can be pulled out in consideration of maintainability. The reaction unit composed of the heating unit and the microreactor can be housed in a compact heat insulating unit in which these are integrated in consideration of operability and maintenance.

  Next, the characteristics of the pump unit will be described. A highly functional and compact three-head type pump is illustrated in order to easily arrange three pumps in the apparatus. In a general two-head type pump, the fluctuation of the load on the motor becomes large because of the cam structure for suppressing the pulsation on the discharge side. In a device that requires a high pressure, such as the device of the present invention, normally a powerful motor is inevitably required, and as a result, an increase in the size of the pump is inevitable.

  On the other hand, the three-head pump has a small load variation and is suitable for downsizing. As for the pulsation, the waveform of one head is similar to a sine wave, and the three heads perform liquid feeding with a phase difference of 120 °. Therefore, the pulsation is originally very small. By combining a high-performance damper in addition to this quality, the pulsation on the discharge side becomes 2 to 3% or less in the high pressure region. Furthermore, the waveform of the three-head format is exactly the same on the suction side as on the discharge side, and continuous suction with low pulsation is possible on the suction side.

  The apparatus according to the present invention has a configuration in which sufficient consideration is given to maintainability. As a consumable part of the pump, a plunger seal is the most frequently replaced. Therefore, it is preferable that the present pump has a configuration in which the seal portion is exposed as soon as the head is removed, and the replacement is very easy for the user. Further, examples of the sealing material include those having optimum durability with respect to the solvent used, such as high-density polyethylene or Teflon (registered trademark) containing carbon graphite.

  The check valve has two stages for each of the suction side and the discharge side, eliminating the machine difference between the heads and ensuring the function of the second stage even if a problem occurs in the first stage. It can be so. Thus, in the present invention, the pump is preferably configured with a three-head pump.

  Next, the heating unit will be described. As a small heater, a small heater using a small and high-performance cartridge heater is used. The microtube is securely fixed from above and below, and the microtube and the heating metal are brought into close contact with each other to improve the heat conduction efficiency. It is preferable to use five cartridge heaters of the high temperature type (maximum operating temperature 850 ° C.). In consideration of temperature rise and cooling, it is preferable that the design has a small heat capacity and the size is 9 cm × 15 cm × 3 cm, and the size is further reduced.

  Heater and microheater are placed in a heat insulation box made of stainless steel (inside ceramic fiber). In consideration of chemical resistance, etc., the surface is made of stainless steel. In addition, a method is used in which the internal atmosphere is released outside by using an air-cooled cooling fan during internal cooling.

  As a small micro heater, the same structure as the small heater is adopted. Considering temperature rise and cooling, the heat capacity is small, and the size is 3.6 cm × 7.6 cm × 2 cm. A structure is used in which the reaction length can be easily changed by modularizing and connecting the same components.

Basically, for example, a joint made by Swagelok is used as the four-way joint, but an irregular four-way joint is used for more efficient space-saving mixing and temperature measurement. In consideration of small size and energy saving, a small air-cooled cooler that combines an aluminum alloy plate, an aluminum heat sink, and a cooling fan is used as the cooling unit. The size is 10 cm × 20 cm × 10 cm, and for example, four fans are used so as to have a capacity of 4 m ³ / min.

  As a feature of the pressure adjusting unit, a pressure adjusting valve using a small and powerful solenoid valve is used. A signal from the pressure sensor is fed back, and the pressure is kept at a set pressure while the needle valve is operated at high speed by a solenoid. The tip of the needle is a flat seal to minimize leakage due to the generated solid matter.

  The dead volume inside the valve is minimized as much as possible in order to take out the resulting composite without stagnation. As for the pressure sensor, a sensor with an internal volume of 4 μl or less is prepared to eliminate the contamination that tends to occur in the general sensor section.

  As a feature of the operation control unit of the apparatus, control by a notebook PC is used in consideration of control flexibility. Communication from the PC is performed by a USB cable, and a microcomputer board for distributing control to the apparatus main body is built in. The image on the operation screen displays the entire flow path, and performs real-time display such as flow rate / temperature in the vicinity of each functional part. When setting a numerical value, clicking the icon of each unit opens a pop-up menu, which becomes an input screen.

  In addition, the display of each flow rate / temperature and the like is taken into the PC as data and can be displayed in a graph or numerical value. The capture interval can be continuously captured in units of 10 seconds for a maximum of 12 hours. When trouble such as clogging of the flow path occurs, a pressure upper limiter is provided for each of the pumps P1 to P3, and the pump stops when the set pressure is exceeded. Also, any key on the PC is set as an emergency stop button, and if an abnormality occurs in the apparatus, all units except P1 including the pump / heater are forcibly stopped. Only P1 is excluded because the entire system is cooled.

  The high temperature / high pressure water / micro space concerted reaction field system of the high temperature / high pressure water microreactor of the present invention will be conceptually described. As shown in FIG. 1, conventional chemical reaction control (complex catalyst), biological In contrast to reaction control (enzymes, etc.), the apparatus of the present invention performs reaction control by hardware and software fusion and generates and reacts reactive species efficiently and quickly and precisely by temperature, pressure, and space-time control. It is possible to synthesize substances ideally, and by using the high-temperature and high-pressure water microreactor of the present invention, it is possible to convert compound A into target substance B by temperature / pressure control on the order of μ seconds. is there.

  By using the apparatus of the present invention, as shown in the reaction temperature profile capable of ultra-high speed heating / cooling (on the order of 0.01 seconds) in FIG. Environmentally friendly with an aqueous medium that enables control of target reactions and suppression of side reactions, 2) reduction of catalysts (noble metals, etc.), omission of protective group modification, reduction of surfactants, simplification of separation, etc. A highly efficient process can be constructed.

  Next, FIG. 3 shows a flow chart of the control system of the high-temperature high-pressure water microreactor of the present invention. In the apparatus control system flow diagram of FIG. 3, the keys of the notebook PC are used to set the flow rate (P1, P2, P3), limiter pressure setting (P1, P2, P3), operating pressure setting (V1), temperature setting (H1, H2). , C1), pressure display (V1, P1, P2, P3), temperature display (H1, H2, C1, T1, T2, T3), heater / block temperature display (H1, H2, C1), Check.

  Next, FIG. 5 shows a flowchart of the entire high-temperature / high-pressure water micro apparatus of the present invention. The apparatus of the present invention has a high-temperature high-pressure water pump, a substrate pump, other substrate pumps, and a small heater for rapid temperature increase downstream of the high-temperature high-pressure water pump. The reaction product is introduced into a reaction section composed of a reactor, a predetermined reaction is performed in the microreactor, the reaction product is rapidly cooled with an air-cooled small cooler, and the reaction product is recovered. The apparatus of the present invention has the greatest feature especially in that it has succeeded in constructing a specific microreactor required for constructing a small high-temperature high-pressure water microreactor.

  FIG. 6 shows an external view of a small microreactor used in the present invention. In the microreactor, a microreaction tube formed by forming a micro-sized groove on the surface of a base material and stacking them is used as a basic unit of a microreactor unit formed in a meandering shape. Or it is configured by connecting a plurality. The flow path length of the microreactor is designed such that the shape and structure of the microreactor tube of the microreactor unit of the basic unit is arbitrarily configured, the number of connections of the microreactor unit is increased or decreased, the microreactor unit Can be arbitrarily set by modularizing and stacking them vertically or in any direction, changing the connection method of the microreactor units, and the like. In this case, the connection method of the micro reaction tube is not particularly limited.

  FIG. 7 shows a configuration example of a microreactor configured by connecting three microreactor units. The number of connected microreactor units is not limited to three, and any number of microreactor units may be connected as necessary, and they can be arranged as modules in the vertical direction. These microreactors are installed in a state where they can be heated in contact with the heating section. It is important that each microreactor unit is installed in such a manner that the heating temperature can be appropriately varied in all or part of the microreactor by the respective heating units in contact with the microreactor units. It is possible to partially set an arbitrary heating temperature condition. The reaction unit composed of the heater of the heating unit and the microreactor can be configured as a compact heat insulating unit structure by arbitrarily combining a connectable heater and a connectable microreactor unit.

  The apparatus of the present invention can be connected by modularizing the microreactor unit constituting the microreactor as a basic unit, the heating temperature corresponding to each unit, or the whole or part of the unit. It was possible to carry out the reaction by setting the conditions arbitrarily, to be able to arbitrarily adjust the length of the micro reaction tube according to the type of chemical reaction, and by these, ultra-fast heating and cooling ( The most characteristic part is that it enables precise reaction control and suppression of side reactions as shown in the reaction temperature profile of FIG. It is.

As the above-described microreactor, as shown in FIG. 9, it is also possible to appropriately use a tube coil in which a groove is formed on the surface of the microtube and a coiled heater is wound around the groove. In this case, the tube coil and multiple installation, by changing the heating temperature Dodo conditions of each coil heaters, it is possible to change the heating temperature of each tube coil appropriately.

FIG. 8 shows a configuration example of a microline for introducing a mixture obtained by mixing high-temperature and high-pressure water, a substrate solution and another substrate solution sent from each pump by a micromixer into a microreactor. . FIG. 9 shows an example of a compact high-temperature / high-pressure water microreactor specialized for the coupling reaction of the high-temperature / high-pressure water microreactor of the present invention. From the liquid feed pump, the substrate, 2 mol% PdCl ₂ + 2M NaCH aqueous solution, and high-temperature high-pressure water are fed to the microreactor consisting of a tube coil to perform the reaction, and the reaction product is rapidly cooled with a cooler and then collected in a collection container The example of a structure of the micro line which performs is shown.

The present invention has the following effects.
(1) A compact high-temperature and high-pressure water microreactor capable of ultra-high-speed heating and cooling (on the order of 0.01 seconds) can be provided.
(2) By using this device, ultra high-speed heating and cooling (on the order of 0.01 seconds) are possible, and efficient material synthesis is possible by rapid and precise temperature, pressure, and space-time control.
(3) Realize precise reaction control, suppression of side reactions, reduction of catalysts (noble metals, etc.), omission of protective group modification, reduction of surfactants, simplification of separation, etc. by using a flow-type apparatus. Can do.
(4) It is possible to provide an environment-friendly high-efficiency process using an aqueous medium.
(5) Continuous synthesis using a reaction field by a high-temperature high-pressure water microreactor is possible.
(6) Labor-saving, resource saving, low emission, and on-demand production in a multi-stage organic production process can be realized.
(7) Time control on the order of microseconds is possible.

It is explanatory drawing of a high temperature / high pressure water-micro space concerted reaction field. It is the reaction temperature profile of the high-temperature / high-pressure water microreactor of the present invention capable of ultrahigh-speed heating / cooling (on the order of 0.01 seconds). It is an apparatus control system flowchart which comprises a high temperature / high pressure water micro reactor. It is an external appearance (photograph) of a high temperature / high pressure water microreactor. It is a flowchart of the whole high temperature / high pressure water microreactor. It is an external view of a small microreactor unit. This is a microreactor module in which three small microreactor units are connected. It is an example of the line structure from a liquid feeding pump to a small microreactor. It is a structural example of the high temperature / high pressure water microreactor specialized for the coupling reaction.

  EXAMPLES Next, although this invention is demonstrated concretely based on an Example, this invention is not limited at all by the following Examples.

  In this example, a high-value-added material compact manufacturing apparatus was manufactured in which a flow-through organic reaction technique using a high-temperature and high-pressure microreactor was adapted to synthesis of an organic dye material for dye-sensitized solar cells. With this device, we have demonstrated and materialized simple manufacturing by combining high-temperature and high-pressure technology (hardware domain) and material manufacturing technology (software domain). In addition, by realizing energy-saving, high-efficiency, on-site, and on-demand manufacturing technology for demand for high-mix low-volume production, we established a distribution-type high-temperature and high-pressure water organic reaction technology.

As a specific content of this apparatus, a compact, simple and inexpensive high-temperature / high-pressure water microreactor was manufactured as a compact apparatus having a power consumption of 2000 Wh or less and 1 m ³ or less. At the same time, specific compound synthesis (organic dye material for dye-sensitized solar cells: MK-2, boasting world-class power generation efficiency among organic dyes, literature: J. Am. Chem, Soc., 2006 , 128, 14256, Chem. Mater., 2008, 20, 3993). That is, in addition to manufacturing and testing a manufacturing apparatus optimized for the existing MK-2 synthesis route, an attempt was made to develop a synthesis route suitable for the MK-2 manufacturing apparatus. As a result, a more efficient manufacturing method was established simultaneously with the development of the MK-2 high-temperature / high-pressure water micro-manufacturing device.

As the basic configuration of the apparatus, the production apparatus is composed of portions of six points below, these were raised compactly package 1 m ³ or less, to obtain the power from a household 100V outlet, the following equipment power 2000Wh It was constructed. FIG. 4 shows a photograph of the appearance of the apparatus (size of main body: not including W500 mm × H350 × D450PC).

  This small high-temperature high-pressure water reactor is composed of 1) liquid feeding section, 2) heating section, 3) reaction section composed of a microreactor, 4) cooling section, 5) pressure control section, and 6) basic operation control section. The external dimensions of the compact high-temperature high-pressure water reactor main body were: width 500 mm × height 350 mm × depth 450 mm, weight 45 kg or less, power source: AC 100 V drive, use adaptive temperature: 5 ° C. to 35 ° C.

  Next, the liquid feeding part is composed of a pump (for substrate feeding), a pump (for catalyst feeding), and a pump (for high temperature and high pressure water feeding). Head type reciprocating pump, discharge capacity: 0.01 mL / min to 5.0 mL / min, pulsation rate: within 3% (40 Mpa), maximum operating pressure: 50 MPa, size: W80 × H81 × D322, others: depending on drain valve Air venting mechanism, power switch (for emergency), and control by PC.

  Further, the pump (catalyst solution dissolution) is a system: 3-head type reciprocating pump, discharge capacity: 0.01 mL / min to 5.0 mL / min, pulsation rate: within 3% (40 Mpa), maximum operating pressure: 50 MPa, Size: W80 × H81 × D322, others: air venting mechanism by drain valve, power switch (for emergency), control by PC.

  The pump (for high temperature and high pressure water feeding) is a system: 3-head type reciprocating pump, discharge capacity: 0.05 mL / min to 20 mL / min, pulsation rate: within 3% (40 MPa), maximum working pressure: 50 MPa, Size: W80 × H81 × D322, others: air venting mechanism by drain valve, power switch (for emergency), control by PC.

  Next, the heating unit is composed of a small heater unit and a micro heater unit, which can be incorporated into a stainless steel heat insulation box, insulated with ceramic fibers, and cooled by an air cooling method when cooled. Equipped with an interface to connect with.

  Small heater part: size: 90mm x 150mm x 30mm, maximum operating temperature: 650 ° C, power consumption: 750W, maximum temperature reaching time: within 5 minutes, maximum possible flow rate: 20mL / min, maximum possible pressure: 50MPa, others : Temperature control by K thermocouple, PC control, and internal piping made from HC C-276.

The size of the micro heater is: 50 mm x 100 mm x 30 mm, maximum operating temperature: 550 ° C, power consumption: 150 W, maximum temperature arrival time: within 5 minutes, maximum possible flow rate: 30 mL / min, maximum possible pressure: 60 Mpa, reactor Long: 15cm and 100cm,
Others: Temperature control by K thermocouple, PC control.

The reaction part composed of the microreactor was based on the microreactor channel diameter: 0.5 mm × 150 mm. In the event of an emergency such as a blockage in the flow path, a pump condition limit was set, and when the set pressure was exceeded, an emergency stop was made. Furthermore, when the pressure can be set again, it can be restarted. The cooling unit is a cooling system: air cooling type (maximum air volume 3.8 m ³ / min), aluminum alloy heat sink (cooling plate), 4 fans, maximum cooling temperature: 500 ° C. → 50 ° C., power consumption: 32 W, large Length: 100 mm × 200 mm × 100 mm, others: temperature monitor by PC.

  Pressure control unit: Drive system: electromagnetic solenoid valve system, detection pressure sensor: dead volume type (content volume 4 microliters), maximum control pressure: 50 MPa, control system: pressure adjustment by solenoid via pressure sensor, others: PC Control.

Operation control unit is controlled by device type: notebook PC, control method: USB connection with the main body,
Capable of capturing measurement data (interval of 10 seconds), capturing up to 12 hours,
Control software: operating without excess or deficiency on Windows (registered trademark), with source code, control terms: flow rate, pressure, temperature.

  Other configurations are equipped with an entire emergency stop button including a heater (excluding high-temperature and high-pressure water pumps). In addition, a safety valve is provided between the high-temperature and high-pressure water pump and the small heater to protect against leakage, failure, and device safety against excessive pressurization when closed.

  As a confirmation test of the produced compact high-temperature / high-pressure water microreactor, a performance test was performed and its capability was confirmed.

As described above in detail, the present invention relates to a compact high-temperature high-pressure water microreactor, and according to the present invention, a compact high-temperature high-pressure water microreactor capable of ultra-high-speed heating / cooling (on the order of 0.01 seconds). Can be provided. By using this device, ultra-high-speed heating / cooling (on the order of 0.01 seconds) is possible, and efficient material synthesis is possible through rapid and precise temperature / pressure / time-space control. By using a flow-type apparatus, precise reaction control, suppression of side reactions, reduction of catalysts (noble metals, etc.), omission of protective group modification, reduction of surfactants, simplification of separation, and the like can be realized. The present invention is useful as providing an environmentally friendly high efficiency process with aqueous media.

Claims (8)

Super-high-speed heating / cooling of 0 to 1 second or less is possible. It is packaged in a package of 1 m ³ or less that incorporates a microreactor. Power consumption is 2000 Wh or less. A compact high-temperature high-pressure water microreactor that can be used for organic reactions to synthesize organic compounds using high-temperature high-pressure water containing
Reaction unit composed of a liquid feeding unit, a mixing unit, a heating unit, and a microreactor for cooling, for high-temperature and high-pressure water feeding, for substrate feeding, and for catalyst feeding, to be applied to a reaction system using an aqueous medium, cooling Part, further having an operation control part,
A plurality of microreactors can communicate with each other, and 1) a microreactor unit comprising a microreaction tube formed by superposing and forming a tube-like groove having a micro-size channel diameter on the surface of a substrate, or 2) It is composed of a microreactor unit consisting of a tube coil in which a groove is formed on the surface of the microtube and a coiled heater is wound around the groove.
The microreactor unit comprising the microreactor tube of 1) above is placed in a state where it can be heated in contact with the heating part, and each microreactor unit can be heated by the respective heating part in contact with them. Or it is installed variably in a part,
The microreactor unit composed of the tube coil of 2) is arranged so that the heating temperature of each tube coil can be changed by changing the heating temperature condition of each coil-shaped heater,
A compact high-temperature and high-pressure water microreactor characterized by having a modular structure with the microreactor unit as a basic unit. The microreactor has a configuration in which a plurality of microreactor units each composed of a microreaction tube formed by forming a tube-like groove having a micro-sized channel diameter on the surface of a base material and overlapping them are connected as a basic unit. The small-sized high-temperature / high-pressure water microreactor according to claim 1, wherein the flow-path length is adjustable.   The whole or part of the microreactor is configured to be heated by a heating unit that is installed so as to be capable of being heated with respect to the microreactor and in which the heating temperature condition can be set to be variable in whole or in part. Small high-temperature high-pressure water microreactor as described.   The small high-temperature high-pressure water microreactor according to claim 1, wherein the ultra-high-speed heating / cooling is ultra-high-speed heating / cooling of 0.01 seconds or less.   The small-sized high-temperature / high-pressure water microreactor according to claim 1, wherein the operation control unit is composed of a notebook PC.   The small-sized high-temperature / high-pressure water microreactor according to claim 1, wherein the cooling unit is composed of an air-cooled cooler.   The small-sized high-temperature / high-pressure water microreactor according to claim 1, wherein the mixing unit is composed of a micromixer.   The small high temperature / high pressure water microreactor according to claim 1, wherein the pump in the liquid feeding section is a syringe pump or a reciprocating pump.