JP5632581B2 - 結腸直腸癌の予後予測 - Google Patents

結腸直腸癌の予後予測 Download PDF

Info

Publication number
JP5632581B2
JP5632581B2 JP2008547140A JP2008547140A JP5632581B2 JP 5632581 B2 JP5632581 B2 JP 5632581B2 JP 2008547140 A JP2008547140 A JP 2008547140A JP 2008547140 A JP2008547140 A JP 2008547140A JP 5632581 B2 JP5632581 B2 JP 5632581B2
Authority
JP
Japan
Prior art keywords
expression
gene
data
prognostic
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008547140A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009521215A5 (enExample
JP2009521215A (ja
Inventor
フジャルマー ネカルダ
フジャルマー ネカルダ
ヤン フリーデリヒス
ヤン フリーデリヒス
ベルンハルト ホルツマン
ベルンハルト ホルツマン
ロベルト ローゼンベルク
ロベルト ローゼンベルク
アンソニー エドマンド リーヴ
アンソニー エドマンド リーヴ
マイケル アラン ブラック
マイケル アラン ブラック
ジョン リンゼイ マコール
ジョン リンゼイ マコール
ユー シン リン
ユー シン リン
ロバート クレイグ ポロック
ロバート クレイグ ポロック
Original Assignee
パシフィック エッジ バイオテクノロジー リミティド
パシフィック エッジ バイオテクノロジー リミティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by パシフィック エッジ バイオテクノロジー リミティド, パシフィック エッジ バイオテクノロジー リミティド filed Critical パシフィック エッジ バイオテクノロジー リミティド
Publication of JP2009521215A publication Critical patent/JP2009521215A/ja
Publication of JP2009521215A5 publication Critical patent/JP2009521215A5/ja
Application granted granted Critical
Publication of JP5632581B2 publication Critical patent/JP5632581B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/30—Microarray design
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
JP2008547140A 2005-12-23 2006-12-22 結腸直腸癌の予後予測 Expired - Fee Related JP5632581B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ544432 2005-12-23
NZ544432A NZ544432A (en) 2005-12-23 2005-12-23 Prognosis prediction for colorectal cancer using a prognositc signature comprising markers ME2 and FAS
PCT/NZ2006/000343 WO2007073220A1 (en) 2005-12-23 2006-12-22 Prognosis prediction for colorectal cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014103714A Division JP6218141B2 (ja) 2005-12-23 2014-05-19 結腸直腸癌の予後予測

Publications (3)

Publication Number Publication Date
JP2009521215A JP2009521215A (ja) 2009-06-04
JP2009521215A5 JP2009521215A5 (enExample) 2013-01-10
JP5632581B2 true JP5632581B2 (ja) 2014-11-26

Family

ID=38188869

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2008547140A Expired - Fee Related JP5632581B2 (ja) 2005-12-23 2006-12-22 結腸直腸癌の予後予測
JP2014103714A Expired - Fee Related JP6218141B2 (ja) 2005-12-23 2014-05-19 結腸直腸癌の予後予測
JP2015257292A Expired - Fee Related JP6058780B2 (ja) 2005-12-23 2015-12-28 結腸直腸癌の予後予測

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014103714A Expired - Fee Related JP6218141B2 (ja) 2005-12-23 2014-05-19 結腸直腸癌の予後予測
JP2015257292A Expired - Fee Related JP6058780B2 (ja) 2005-12-23 2015-12-28 結腸直腸癌の予後予測

Country Status (10)

Country Link
US (3) US10422005B2 (enExample)
EP (3) EP2371972B1 (enExample)
JP (3) JP5632581B2 (enExample)
KR (3) KR101530689B1 (enExample)
CN (1) CN101389957B (enExample)
AU (1) AU2006328023B2 (enExample)
CA (2) CA3015335A1 (enExample)
ES (3) ES2525219T3 (enExample)
NZ (3) NZ544432A (enExample)
WO (1) WO2007073220A1 (enExample)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2783348B1 (fr) * 1998-09-15 2000-10-13 Alstom Technology Methode de discrimination entre un arc interne et un arc de coupure dans un disjoncteur de moyenne ou de haute tension
EP2947160B1 (en) 2004-04-09 2017-07-12 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
NZ593226A (en) 2006-01-11 2012-10-26 Genomic Health Inc Gene expression markers (efnb2) for colorectal cancer prognosis
ES2599816T3 (es) * 2006-07-21 2017-02-03 Epigenomics Ag Métodos relacionados con el gen GLI3 para la detección de cáncer colorrectal
DE102006035393A1 (de) * 2006-11-02 2008-05-15 Signature Diagnostics Ag Prognostische Marker für die Klassifizierung des dreijährigen progessionsfreien Überlebens von Patienten mit Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
US20090076734A1 (en) 2007-03-22 2009-03-19 Torres-Roca Javier F Gene Signature for the Prediction of Radiation Therapy Response
US20080234946A1 (en) * 2007-03-22 2008-09-25 University Of South Florida Predictive radiosensitivity network model
EP2544006A1 (en) * 2007-06-04 2013-01-09 Diagnoplex Biomarker combinations for colorectal cancer
NZ562237A (en) * 2007-10-05 2011-02-25 Pacific Edge Biotechnology Ltd Proliferation signature and prognosis for gastrointestinal cancer
ES2332557B1 (es) 2007-12-04 2011-02-02 Universidad Autonoma De Madrid Huella genomica para el pronostico de la evolucion de adenocarcinoma colorectal.
CN104376147B (zh) * 2009-02-02 2018-07-17 罗格斯新泽西州立大学 基于图像的风险分数的图像分析系统
NZ596054A (en) 2009-05-01 2013-07-26 Genomic Health Inc Gene expression profile algorithm and test for likelihood of recurrence of colorectal cancer and response to chemotherapy
EP2454596B1 (en) 2009-07-16 2014-06-11 Roche Diagnostics GmbH Flap endonuclease-1 as a marker for cancer
US8445271B2 (en) 2010-05-03 2013-05-21 Enzo Life Sciences, Inc. Processes and kits for determining multi-drug resistance of cells
WO2011140662A1 (en) * 2010-05-13 2011-11-17 The Royal Institution For The Advancement Of Learning / Mcgill University Cux1 signature for determination of cancer clinical outcome
JP5916718B2 (ja) * 2010-06-04 2016-05-11 ビオメリューＢｉｏｍｅｒｉｅｕｘ 結腸直腸癌の予後判定のための方法及びキット
US9539323B2 (en) 2010-08-06 2017-01-10 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for malic enzyme 2 (ME2) as a target for cancer therapy
KR101401561B1 (ko) * 2010-12-30 2014-06-11 주식회사 바이오인프라 복합 바이오마커를 활용한 암 진단 정보 생성 방법, 및 암 진단 예측 시스템 장치
US20120184454A1 (en) * 2011-01-14 2012-07-19 Kalady Matthew F Gene signature is associated with early stage rectal cancer recurrence
CN102183662A (zh) * 2011-03-22 2011-09-14 浙江大学 一种大肠癌预后预测模型的建立方法
CA2857073A1 (en) * 2011-11-28 2013-06-06 Institucio Catalana De Recerca I Estudis Avancats Methods and kits for the prognosis of colorectal cancer
US9977033B2 (en) * 2012-09-11 2018-05-22 The Board Of Regents Of The University Of Texas System Methods for assessing cancer recurrence
KR20160045547A (ko) 2014-10-17 2016-04-27 에스케이텔레콤 주식회사 췌장암 진단용 조성물 및 이를 이용한 췌장암 진단방법
CN105021828B (zh) * 2015-07-20 2017-07-28 上海交通大学医学院附属新华医院 通过检测三期结直肠肿瘤患者血清预测肿瘤患者预后
SG11201806609TA (en) 2016-02-02 2018-09-27 Guardant Health Inc Cancer evolution detection and diagnostic
WO2017143322A1 (en) 2016-02-18 2017-08-24 University Of South Florida Materials and methods for detecting cancer based on urinary levels of rhamm
US20190242875A1 (en) 2016-05-10 2019-08-08 National University Corporation Tokyo Medical And Dental University Expression Inhibitor of Inflammation Promoting Factor, Screening Method for Active Ingredient Thereof, Expression Cassette Useful for Said Method, Diagnostic Agent and Diagnosis Method
US11164082B2 (en) 2017-02-28 2021-11-02 Anixa Diagnostics Corporation Methods for using artificial neural network analysis on flow cytometry data for cancer diagnosis
US9934364B1 (en) 2017-02-28 2018-04-03 Anixa Diagnostics Corporation Methods for using artificial neural network analysis on flow cytometry data for cancer diagnosis
US10360499B2 (en) * 2017-02-28 2019-07-23 Anixa Diagnostics Corporation Methods for using artificial neural network analysis on flow cytometry data for cancer diagnosis
WO2018231772A1 (en) 2017-06-13 2018-12-20 Bostongene Corporation Systems and methods for identifying responders and non-responders to immune checkpoint blockade therapy
EP3719124A4 (en) 2017-11-09 2021-09-01 National University Corporation Tokyo Medical and Dental University CANCER-PROMOTING EXPRESSION INHIBITOR, SCREENING METHOD FOR ACTIVE SUBSTANCE, USEFUL EXPRESSION CASSETTE IN SUCH METHOD, DIAGNOSIS DRUG AND DIAGNOSIS METHOD
WO2019154884A1 (en) * 2018-02-07 2019-08-15 Ecole Polytechnique Federale De Lausanne (Epfl) Method for determining cancer invasiveness and patient prognosis
WO2019173233A1 (en) * 2018-03-05 2019-09-12 Anixa Diagnostics Corporation Methods for using artificial neural network analysis on flow cytometry data for cancer diagnosis
TW202018727A (zh) 2018-11-09 2020-05-16 財團法人工業技術研究院 整體式學習預測方法與系統
CN111321221B (zh) * 2018-12-14 2022-09-23 中国医学科学院肿瘤医院 用于预测直肠癌局部切除手术后复发风险的组合物、微阵列和计算机系统
CN109599181B (zh) * 2019-01-09 2021-04-16 中国医学科学院肿瘤医院 一种在治疗前针对t3-larc患者的生存预测系统及预测方法
CA3128973A1 (en) 2019-03-04 2020-09-10 Bhaskar Bhattacharyya Data compression and communication using machine learning
CN109811057B (zh) * 2019-03-27 2022-02-22 中山大学附属第六医院 缺氧相关基因在结直肠癌预测系统中的应用
CN109762907B (zh) * 2019-03-27 2022-02-22 中山大学附属第六医院 缺氧相关基因在预测i/ii期结直肠癌的试剂盒中的应用
US11154240B2 (en) 2019-04-02 2021-10-26 Kpn Innovations Llc Methods and systems for utilizing diagnostics for informed vibrant constitutional guidance
CN110246591B (zh) * 2019-07-15 2021-11-05 中国中医科学院西苑医院 一种中医药治疗人群的预后预测系统
CN112342295A (zh) * 2019-08-06 2021-02-09 中山大学孙逸仙纪念医院 一种检测人结直肠癌的肿瘤标志物及其应用
CN110791565B (zh) * 2019-09-29 2021-09-03 浙江大学 一种用于ii期结直肠癌复发预测的预后标记基因及随机生存森林模型
WO2021119761A1 (en) 2019-12-20 2021-06-24 Hudson Institute of Medical Research Cxcl10 binding proteins and uses thereof
US12020417B2 (en) * 2020-04-24 2024-06-25 Camtek Ltd. Method and system for classifying defects in wafer using wafer-defect images, based on deep learning
US11289206B2 (en) 2020-06-02 2022-03-29 Kpn Innovations, Llc. Artificial intelligence methods and systems for constitutional analysis using objective functions
US12176108B2 (en) 2020-06-02 2024-12-24 Kpn Innovations Llc Artificial intelligence methods and systems for constitutional analysis using objective functions
US11211158B1 (en) 2020-08-31 2021-12-28 Kpn Innovations, Llc. System and method for representing an arranged list of provider aliment possibilities
CN112301131B (zh) * 2020-11-13 2021-10-26 中国医学科学院基础医学研究所 Rnf138作为预测结直肠癌对sc75741治疗敏感性的生物标志物的应用
CN113591919B (zh) * 2021-06-29 2023-07-21 复旦大学附属中山医院 基于ai对早期肝细胞癌术后复发预后的分析方法及系统
WO2023128419A1 (ko) * 2021-12-31 2023-07-06 주식회사 이노제닉스 대장암 및 대장 용종 또는 진행 선종의 선별 방법 및 그 응용
IT202200001817A1 (it) 2022-02-02 2023-08-02 Aizoon S R L Procedimento per la prognosi di una malattia in seguito ad un trattamento terapeutico, relativo sistema e prodotto informatico
CN114652814B (zh) * 2022-03-11 2023-02-03 郑州大学第一附属医院 一种免疫检查点抑制剂及应用
IT202200005861A1 (it) 2022-03-24 2023-09-24 Aizoon S R L Procedimento per stimare una variabile di interesse associata ad una data malattia in funzione di una pluralità di diversi dati omici, relativo dispositivo e prodotto informatico
CA3207405A1 (en) 2022-07-25 2024-01-25 Aizoon S.r.l. Method for providing a clinical decision support, corresponding system for providing a clinical decision support, and computer program product
WO2024138106A1 (en) * 2022-12-23 2024-06-27 The Wistar Institute Of Anatomy And Biology Compositions and methods for identification of hypomorphic p53 variants
CN115938590B (zh) * 2023-02-09 2023-05-02 四川大学华西医院 结直肠癌术后lars预测模型的构建方法及预测系统
CN117947166B (zh) * 2024-01-30 2025-08-29 复旦大学附属肿瘤医院 用于肠癌预后的标志物组、产品、系统及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582908B2 (en) * 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
GB9805918D0 (en) * 1998-03-19 1998-05-13 Nycomed Amersham Plc Sequencing by hybridisation
JP2004510951A (ja) * 1999-03-15 2004-04-08 イオス　バイオテクノロジー，インコーポレイティド 結腸直腸癌を診断する新規の方法、組成物、結腸直腸癌調節のためのスクリーニング法
WO2002006867A2 (en) 2000-07-18 2002-01-24 Kvh Industries, Inc. Method of incorporating optical material into an optical fiber
US20030077568A1 (en) * 2000-09-15 2003-04-24 Gish Kurt C. Methods of diagnosis of colorectal cancer, compositions and methods of screening for colorectal cancer modulators
AU2002252144A1 (en) * 2001-02-27 2002-09-12 Case Western Reserve University Novel methods of diagnosis of metastatic colorectal cancer, compositions and methods of screening for modulators of metastatic colorectal cancer
US20040191782A1 (en) * 2003-03-31 2004-09-30 Yixin Wang Colorectal cancer prognostics
US20070117164A1 (en) 2003-04-08 2007-05-24 Raskov Hans H Method for detection of colorectal cancer in human samples
KR20060031809A (ko) * 2003-06-09 2006-04-13 더 리젠츠 오브 더 유니버시티 오브 미시간 암 치료 및 진단용 조성물 및 방법
US20050048494A1 (en) * 2003-08-28 2005-03-03 Yixin Wang Colorectal cancer prognostics
CA2592504A1 (en) * 2003-12-27 2005-07-14 Aros Applied Biotechnology Aps Classification of cancer

Also Published As

Publication number Publication date
EP1977237A4 (en) 2009-03-11
KR101562644B1 (ko) 2015-10-23
JP6058780B2 (ja) 2017-01-11
US20090181384A1 (en) 2009-07-16
KR101530689B1 (ko) 2015-06-22
US20200140955A1 (en) 2020-05-07
CN101389957A (zh) 2009-03-18
EP2392678A3 (en) 2012-03-21
CA2640352C (en) 2018-10-02
EP2371972A1 (en) 2011-10-05
US11180815B2 (en) 2021-11-23
NZ544432A (en) 2009-07-31
KR20130105764A (ko) 2013-09-25
ES2525219T3 (es) 2014-12-19
JP2014193172A (ja) 2014-10-09
EP2392678A2 (en) 2011-12-07
KR20080102360A (ko) 2008-11-25
ES2484702T3 (es) 2014-08-12
JP6218141B2 (ja) 2017-10-25
ES2536233T3 (es) 2015-05-21
EP2371972B1 (en) 2014-04-23
CN101389957B (zh) 2013-08-21
EP1977237A1 (en) 2008-10-08
EP1977237B1 (en) 2014-09-10
KR20150005726A (ko) 2015-01-14
CA3015335A1 (en) 2007-06-28
NZ597363A (en) 2013-08-30
NZ586616A (en) 2012-04-27
KR101579934B1 (ko) 2015-12-28
WO2007073220A1 (en) 2007-06-28
AU2006328023B2 (en) 2013-09-26
WO2007073220A9 (en) 2007-11-08
US20160068916A1 (en) 2016-03-10
CA2640352A1 (en) 2007-06-28
US10422005B2 (en) 2019-09-24
JP2009521215A (ja) 2009-06-04
AU2006328023A1 (en) 2007-06-28
JP2016052329A (ja) 2016-04-14
EP2392678B1 (en) 2015-02-11

Similar Documents

Publication Publication Date Title
JP6058780B2 (ja) 結腸直腸癌の予後予測
JP6824923B2 (ja) 胃腸癌での増殖の徴候及び予後
JP6404304B2 (ja) メラノーマ癌の予後予測
NZ555353A (en) TNF antagonists
HK1145342B (en) Prognosis prediction for melanoma cancer

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20091221

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120514

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120813

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120822

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20121114

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121217

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130315

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130325

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130617

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140120

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140519

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140620

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20140725

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140910

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20141010

R150 Certificate of patent or registration of utility model

Ref document number: 5632581

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees