CA3015335A1 - Prognosis prediction for colorectal cancer - Google Patents
Prognosis prediction for colorectal cancerInfo
- Publication number
- CA3015335A1 CA3015335A1 CA3015335A CA3015335A CA3015335A1 CA 3015335 A1 CA3015335 A1 CA 3015335A1 CA 3015335 A CA3015335 A CA 3015335A CA 3015335 A CA3015335 A CA 3015335A CA 3015335 A1 CA3015335 A1 CA 3015335A1
- Authority
- CA
- Canada
- Prior art keywords
- fas
- dlgap4
- rbm25
- wars
- tyms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000001333 Colorectal Neoplasms Diseases 0.000 title claims abstract description 64
- 238000004393 prognosis Methods 0.000 title claims abstract description 61
- 206010009944 Colon cancer Diseases 0.000 title claims abstract description 59
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 151
- 238000000034 method Methods 0.000 claims abstract description 139
- 108090000623 proteins and genes Proteins 0.000 claims description 243
- 230000014509 gene expression Effects 0.000 claims description 150
- 239000000523 sample Substances 0.000 claims description 130
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims description 104
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 claims description 102
- 101000610019 Homo sapiens Protocadherin beta-11 Proteins 0.000 claims description 93
- 102100037983 Disks large-associated protein 4 Human genes 0.000 claims description 84
- 101000951335 Homo sapiens Disks large-associated protein 4 Proteins 0.000 claims description 84
- 101000964894 Bos taurus 14-3-3 protein zeta/delta Proteins 0.000 claims description 79
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims description 79
- 101000914155 Homo sapiens Cadherin EGF LAG seven-pass G-type receptor 1 Proteins 0.000 claims description 61
- 101001016790 Homo sapiens NAD-dependent malic enzyme, mitochondrial Proteins 0.000 claims description 61
- 102000004169 proteins and genes Human genes 0.000 claims description 52
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 46
- 230000000306 recurrent effect Effects 0.000 claims description 39
- 238000004458 analytical method Methods 0.000 claims description 32
- 239000003550 marker Substances 0.000 claims description 25
- 238000012706 support-vector machine Methods 0.000 claims description 19
- 108091034117 Oligonucleotide Proteins 0.000 claims description 12
- 206010038111 Recurrent cancer Diseases 0.000 claims description 12
- 239000002299 complementary DNA Substances 0.000 claims description 12
- 230000003247 decreasing effect Effects 0.000 claims description 12
- 239000000758 substrate Substances 0.000 claims description 11
- 108020004999 messenger RNA Proteins 0.000 claims description 9
- 230000001105 regulatory effect Effects 0.000 claims description 9
- 238000013528 artificial neural network Methods 0.000 claims description 6
- 230000007423 decrease Effects 0.000 claims description 6
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 5
- 238000011272 standard treatment Methods 0.000 claims description 5
- 238000011529 RT qPCR Methods 0.000 claims description 4
- 239000002773 nucleotide Substances 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 3
- 125000003729 nucleotide group Chemical group 0.000 claims description 3
- 230000002441 reversible effect Effects 0.000 claims description 3
- 238000007619 statistical method Methods 0.000 claims description 3
- 238000007636 ensemble learning method Methods 0.000 claims description 2
- 238000003018 immunoassay Methods 0.000 claims description 2
- 102100040142 Protocadherin beta-11 Human genes 0.000 claims 2
- 201000011510 cancer Diseases 0.000 abstract description 54
- 230000004083 survival effect Effects 0.000 abstract description 22
- 238000011282 treatment Methods 0.000 abstract description 19
- 230000007774 longterm Effects 0.000 abstract description 6
- 239000000203 mixture Substances 0.000 abstract description 4
- 230000002068 genetic effect Effects 0.000 abstract description 3
- 238000011277 treatment modality Methods 0.000 abstract description 2
- -1 large bowel) Diseases 0.000 description 154
- 102100032457 NAD-dependent malic enzyme, mitochondrial Human genes 0.000 description 92
- 102100027478 RNA-binding protein 25 Human genes 0.000 description 86
- 101000580720 Homo sapiens RNA-binding protein 25 Proteins 0.000 description 85
- 101000640976 Homo sapiens Tryptophan-tRNA ligase, cytoplasmic Proteins 0.000 description 81
- 102100034300 Tryptophan-tRNA ligase, cytoplasmic Human genes 0.000 description 81
- 101000809797 Homo sapiens Thymidylate synthase Proteins 0.000 description 74
- 102100038618 Thymidylate synthase Human genes 0.000 description 74
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 description 72
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 description 72
- 101000705759 Homo sapiens Proteasome activator complex subunit 2 Proteins 0.000 description 72
- 102100031299 Proteasome activator complex subunit 2 Human genes 0.000 description 72
- 102100041013 Glia maturation factor beta Human genes 0.000 description 71
- 101001039387 Homo sapiens Glia maturation factor beta Proteins 0.000 description 71
- 102100021769 Mitochondrial 2-oxoglutarate/malate carrier protein Human genes 0.000 description 71
- 108091006417 SLC25A11 Proteins 0.000 description 71
- 102100025279 C-X-C motif chemokine 11 Human genes 0.000 description 64
- 102100036170 C-X-C motif chemokine 9 Human genes 0.000 description 64
- 101000858060 Homo sapiens C-X-C motif chemokine 11 Proteins 0.000 description 64
- 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 description 64
- 108010044012 STAT1 Transcription Factor Proteins 0.000 description 62
- 102100029904 Signal transducer and activator of transcription 1-alpha/beta Human genes 0.000 description 62
- 101001023513 Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Proteins 0.000 description 61
- 102100035383 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Human genes 0.000 description 61
- 101000985328 Homo sapiens Methenyltetrahydrofolate cyclohydrolase Proteins 0.000 description 59
- 102100028687 Methenyltetrahydrofolate cyclohydrolase Human genes 0.000 description 59
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 56
- 102100034769 Thioredoxin-dependent peroxide reductase, mitochondrial Human genes 0.000 description 55
- 101001090050 Homo sapiens Thioredoxin-dependent peroxide reductase, mitochondrial Proteins 0.000 description 54
- 102100033985 Heterogeneous nuclear ribonucleoprotein D0 Human genes 0.000 description 53
- 101001017535 Homo sapiens Heterogeneous nuclear ribonucleoprotein D0 Proteins 0.000 description 53
- 101000587430 Homo sapiens Serine/arginine-rich splicing factor 2 Proteins 0.000 description 51
- 108091006262 SLC4A4 Proteins 0.000 description 51
- 102100029666 Serine/arginine-rich splicing factor 2 Human genes 0.000 description 51
- 102000006633 Sodium-Bicarbonate Symporters Human genes 0.000 description 51
- 102000005233 Eukaryotic Initiation Factor-4E Human genes 0.000 description 48
- 108060002636 Eukaryotic Initiation Factor-4E Proteins 0.000 description 48
- 102100026753 Lymphokine-activated killer T-cell-originated protein kinase Human genes 0.000 description 45
- 101000762967 Homo sapiens Lymphokine-activated killer T-cell-originated protein kinase Proteins 0.000 description 44
- 102100026152 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon Human genes 0.000 description 41
- 101000691569 Homo sapiens 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon Proteins 0.000 description 41
- 229920001184 polypeptide Polymers 0.000 description 40
- 101001122801 Homo sapiens Pre-mRNA-processing factor 17 Proteins 0.000 description 38
- 102100028730 Pre-mRNA-processing factor 17 Human genes 0.000 description 38
- 102000004196 processed proteins & peptides Human genes 0.000 description 38
- 201000010099 disease Diseases 0.000 description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 31
- 101000766035 Homo sapiens tRNA (guanine(37)-N1)-methyltransferase Proteins 0.000 description 30
- 102100026250 tRNA (guanine(37)-N1)-methyltransferase Human genes 0.000 description 30
- 210000001519 tissue Anatomy 0.000 description 29
- 102100035654 Cathepsin S Human genes 0.000 description 28
- 102100020880 Kit ligand Human genes 0.000 description 27
- 101000947086 Homo sapiens Cathepsin S Proteins 0.000 description 26
- 101000576901 Homo sapiens Serine/threonine-protein kinase MRCK alpha Proteins 0.000 description 26
- 102100025352 Serine/threonine-protein kinase MRCK alpha Human genes 0.000 description 26
- 238000002493 microarray Methods 0.000 description 26
- 102100040877 E3 ubiquitin-protein ligase MARCHF5 Human genes 0.000 description 25
- 101001039881 Homo sapiens E3 ubiquitin-protein ligase MARCHF5 Proteins 0.000 description 25
- 101000716729 Homo sapiens Kit ligand Proteins 0.000 description 25
- 101001038300 Homo sapiens Protein ERGIC-53 Proteins 0.000 description 25
- 101000945477 Homo sapiens Thymidine kinase, cytosolic Proteins 0.000 description 25
- 102100040252 Protein ERGIC-53 Human genes 0.000 description 25
- 102100034838 Thymidine kinase, cytosolic Human genes 0.000 description 25
- 239000013615 primer Substances 0.000 description 25
- 108090000067 ADP-Ribosylation Factor 6 Proteins 0.000 description 24
- 101001006878 Homo sapiens Kelch-like protein 24 Proteins 0.000 description 24
- 102100027794 Kelch-like protein 24 Human genes 0.000 description 24
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 24
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 24
- 102000034257 ADP-Ribosylation Factor 6 Human genes 0.000 description 23
- 102100027573 ATP synthase subunit alpha, mitochondrial Human genes 0.000 description 23
- 108020004414 DNA Proteins 0.000 description 23
- 101001046554 Dictyostelium discoideum Thymidine kinase 1 Proteins 0.000 description 23
- 101000936262 Homo sapiens ATP synthase subunit alpha, mitochondrial Proteins 0.000 description 23
- 101001055333 Homo sapiens Intraflagellar transport protein 20 homolog Proteins 0.000 description 23
- 102100026220 Intraflagellar transport protein 20 homolog Human genes 0.000 description 23
- 102100030267 Serine/threonine-protein kinase PLK4 Human genes 0.000 description 23
- 102100035115 Testin Human genes 0.000 description 23
- 238000012360 testing method Methods 0.000 description 23
- 102100029234 Histone-lysine N-methyltransferase NSD2 Human genes 0.000 description 22
- 101000634048 Homo sapiens Histone-lysine N-methyltransferase NSD2 Proteins 0.000 description 22
- 101000582914 Homo sapiens Serine/threonine-protein kinase PLK4 Proteins 0.000 description 22
- 102100033095 Translation factor GUF1, mitochondrial Human genes 0.000 description 22
- 210000004027 cell Anatomy 0.000 description 22
- 238000002790 cross-validation Methods 0.000 description 22
- 101001071076 Homo sapiens Translation factor GUF1, mitochondrial Proteins 0.000 description 21
- 102100034582 E3 ubiquitin/ISG15 ligase TRIM25 Human genes 0.000 description 20
- 102100030385 Granzyme B Human genes 0.000 description 20
- 101000848655 Homo sapiens E3 ubiquitin/ISG15 ligase TRIM25 Proteins 0.000 description 20
- 101001009603 Homo sapiens Granzyme B Proteins 0.000 description 20
- 101000809257 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 4 Proteins 0.000 description 20
- 102100038463 Ubiquitin carboxyl-terminal hydrolase 4 Human genes 0.000 description 20
- 230000027455 binding Effects 0.000 description 20
- 102100033175 Ethanolamine kinase 1 Human genes 0.000 description 19
- 102100025989 Glyoxalase domain-containing protein 4 Human genes 0.000 description 19
- 101000857136 Homo sapiens Glyoxalase domain-containing protein 4 Proteins 0.000 description 19
- 239000003446 ligand Substances 0.000 description 19
- 238000010200 validation analysis Methods 0.000 description 19
- 102100026980 Exocyst complex component 5 Human genes 0.000 description 18
- 102100034553 Fanconi anemia group J protein Human genes 0.000 description 18
- 101000851032 Homo sapiens Ethanolamine kinase 1 Proteins 0.000 description 18
- 101000911703 Homo sapiens Exocyst complex component 5 Proteins 0.000 description 18
- 101000848171 Homo sapiens Fanconi anemia group J protein Proteins 0.000 description 18
- 108010071034 Retinoblastoma-Binding Protein 4 Proteins 0.000 description 18
- 102000007508 Retinoblastoma-Binding Protein 4 Human genes 0.000 description 18
- 102100038069 Interferon regulatory factor 8 Human genes 0.000 description 17
- 238000013459 approach Methods 0.000 description 17
- 238000007418 data mining Methods 0.000 description 17
- 102000040430 polynucleotide Human genes 0.000 description 17
- 108091033319 polynucleotide Proteins 0.000 description 17
- 238000012549 training Methods 0.000 description 17
- 102100032951 Condensin complex subunit 2 Human genes 0.000 description 16
- 102100036448 Endothelial PAS domain-containing protein 1 Human genes 0.000 description 16
- 101000942617 Homo sapiens Condensin complex subunit 2 Proteins 0.000 description 16
- 101001032345 Homo sapiens Interferon regulatory factor 8 Proteins 0.000 description 16
- 101000615933 Homo sapiens Phosphoserine aminotransferase Proteins 0.000 description 16
- 102100021768 Phosphoserine aminotransferase Human genes 0.000 description 16
- 108010018033 endothelial PAS domain-containing protein 1 Proteins 0.000 description 16
- 238000010606 normalization Methods 0.000 description 16
- 239000002157 polynucleotide Substances 0.000 description 16
- 230000008569 process Effects 0.000 description 16
- 239000000047 product Substances 0.000 description 16
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 description 15
- 108010012236 Chemokines Proteins 0.000 description 15
- 102100035688 Guanylate-binding protein 1 Human genes 0.000 description 15
- 108010047613 PTB-Associated Splicing Factor Proteins 0.000 description 15
- 102100032015 Serine/threonine-protein kinase tousled-like 1 Human genes 0.000 description 15
- 102100027780 Splicing factor, proline- and glutamine-rich Human genes 0.000 description 15
- 238000009396 hybridization Methods 0.000 description 15
- 230000035945 sensitivity Effects 0.000 description 15
- 102000019034 Chemokines Human genes 0.000 description 14
- 102100032978 Condensin-2 complex subunit D3 Human genes 0.000 description 14
- 102100029588 Deoxycytidine kinase Human genes 0.000 description 14
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 description 14
- 101000942612 Homo sapiens Condensin-2 complex subunit D3 Proteins 0.000 description 14
- 101000795624 Homo sapiens Pre-rRNA-processing protein TSR1 homolog Proteins 0.000 description 14
- 101000637839 Homo sapiens Serine/threonine-protein kinase tousled-like 1 Proteins 0.000 description 14
- 102100031564 Pre-rRNA-processing protein TSR1 homolog Human genes 0.000 description 14
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 14
- 230000000694 effects Effects 0.000 description 14
- 102100037488 G2 and S phase-expressed protein 1 Human genes 0.000 description 13
- 101001026457 Homo sapiens G2 and S phase-expressed protein 1 Proteins 0.000 description 13
- 101000957259 Homo sapiens Mitotic spindle assembly checkpoint protein MAD2A Proteins 0.000 description 13
- 101000652226 Homo sapiens Suppressor of cytokine signaling 6 Proteins 0.000 description 13
- 102100038792 Mitotic spindle assembly checkpoint protein MAD2A Human genes 0.000 description 13
- 102100031081 Serine/threonine-protein kinase Chk1 Human genes 0.000 description 13
- 102100030529 Suppressor of cytokine signaling 7 Human genes 0.000 description 13
- 210000000349 chromosome Anatomy 0.000 description 13
- 239000012634 fragment Substances 0.000 description 13
- 238000003757 reverse transcription PCR Methods 0.000 description 13
- 102100034192 Guanine nucleotide exchange factor MSS4 Human genes 0.000 description 12
- 101000777293 Homo sapiens Serine/threonine-protein kinase Chk1 Proteins 0.000 description 12
- 101000874827 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) Dephospho-CoA kinase Proteins 0.000 description 12
- 238000003753 real-time PCR Methods 0.000 description 12
- 101001134268 Homo sapiens Guanine nucleotide exchange factor MSS4 Proteins 0.000 description 11
- 101001001336 Homo sapiens Guanylate-binding protein 1 Proteins 0.000 description 11
- 101710104492 NUP210 Proteins 0.000 description 11
- 102100035570 Nuclear pore membrane glycoprotein 210 Human genes 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 11
- 230000028993 immune response Effects 0.000 description 11
- 102100025593 Calmodulin-regulated spectrin-associated protein 2 Human genes 0.000 description 10
- 102100033720 DNA replication licensing factor MCM6 Human genes 0.000 description 10
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 10
- 102100022107 Holliday junction recognition protein Human genes 0.000 description 10
- 101000932961 Homo sapiens Calmodulin-regulated spectrin-associated protein 2 Proteins 0.000 description 10
- 101001018484 Homo sapiens DNA replication licensing factor MCM6 Proteins 0.000 description 10
- 101001045907 Homo sapiens Holliday junction recognition protein Proteins 0.000 description 10
- 101000929583 Homo sapiens N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 Proteins 0.000 description 10
- 102100036658 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 Human genes 0.000 description 10
- 239000000427 antigen Substances 0.000 description 10
- 108091007433 antigens Proteins 0.000 description 10
- 102000036639 antigens Human genes 0.000 description 10
- 230000001419 dependent effect Effects 0.000 description 10
- 230000006870 function Effects 0.000 description 10
- 102100027310 Bromodomain adjacent to zinc finger domain protein 1A Human genes 0.000 description 9
- 102100025277 C-X-C motif chemokine 13 Human genes 0.000 description 9
- 101000937778 Homo sapiens Bromodomain adjacent to zinc finger domain protein 1A Proteins 0.000 description 9
- 101000858064 Homo sapiens C-X-C motif chemokine 13 Proteins 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 9
- 238000013461 design Methods 0.000 description 9
- 239000002987 primer (paints) Substances 0.000 description 9
- 101000998629 Homo sapiens Importin subunit beta-1 Proteins 0.000 description 8
- 102100033258 Importin subunit beta-1 Human genes 0.000 description 8
- 239000012190 activator Substances 0.000 description 8
- 230000035755 proliferation Effects 0.000 description 8
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 7
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 description 7
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 7
- 230000003321 amplification Effects 0.000 description 7
- 238000003491 array Methods 0.000 description 7
- 238000010276 construction Methods 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 238000003199 nucleic acid amplification method Methods 0.000 description 7
- 102000005962 receptors Human genes 0.000 description 7
- 108020003175 receptors Proteins 0.000 description 7
- 238000001356 surgical procedure Methods 0.000 description 7
- 239000011701 zinc Substances 0.000 description 7
- 229910052725 zinc Inorganic materials 0.000 description 7
- 101150092328 22 gene Proteins 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 102100022002 CD59 glycoprotein Human genes 0.000 description 6
- 206010027476 Metastases Diseases 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000000692 Student's t-test Methods 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 239000000975 dye Substances 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 238000012353 t test Methods 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 101150040471 19 gene Proteins 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 102000003960 Ligases Human genes 0.000 description 5
- 108090000364 Ligases Proteins 0.000 description 5
- 101710163270 Nuclease Proteins 0.000 description 5
- 108010029485 Protein Isoforms Proteins 0.000 description 5
- 102000001708 Protein Isoforms Human genes 0.000 description 5
- 210000001744 T-lymphocyte Anatomy 0.000 description 5
- 102000040945 Transcription factor Human genes 0.000 description 5
- 108091023040 Transcription factor Proteins 0.000 description 5
- 230000002159 abnormal effect Effects 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 210000001072 colon Anatomy 0.000 description 5
- 230000000875 corresponding effect Effects 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 238000002372 labelling Methods 0.000 description 5
- 238000012423 maintenance Methods 0.000 description 5
- 230000009401 metastasis Effects 0.000 description 5
- 238000012775 microarray technology Methods 0.000 description 5
- 238000000746 purification Methods 0.000 description 5
- 210000004881 tumor cell Anatomy 0.000 description 5
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 4
- 239000004475 Arginine Substances 0.000 description 4
- 102100039534 Calcium-activated chloride channel regulator 4 Human genes 0.000 description 4
- 201000009030 Carcinoma Diseases 0.000 description 4
- 102100037078 Complement component 1 Q subcomponent-binding protein, mitochondrial Human genes 0.000 description 4
- 102000053602 DNA Human genes 0.000 description 4
- 101710169507 DNA-binding protein REB1 Proteins 0.000 description 4
- 101710088194 Dehydrogenase Proteins 0.000 description 4
- 102100031780 Endonuclease Human genes 0.000 description 4
- 102100035099 General transcription factor 3C polypeptide 5 Human genes 0.000 description 4
- 102100032610 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Human genes 0.000 description 4
- 101710110781 Guanylate-binding protein 1 Proteins 0.000 description 4
- 101000888577 Homo sapiens Calcium-activated chloride channel regulator 4 Proteins 0.000 description 4
- 101000596761 Homo sapiens General transcription factor 3C polypeptide 5 Proteins 0.000 description 4
- 101001014590 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Proteins 0.000 description 4
- 101001014594 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Proteins 0.000 description 4
- 101000896484 Homo sapiens Mitotic checkpoint protein BUB3 Proteins 0.000 description 4
- 101001014610 Homo sapiens Neuroendocrine secretory protein 55 Proteins 0.000 description 4
- 101000711744 Homo sapiens Non-secretory ribonuclease Proteins 0.000 description 4
- 101001081953 Homo sapiens Phosphoribosylaminoimidazole carboxylase Proteins 0.000 description 4
- 101000797903 Homo sapiens Protein ALEX Proteins 0.000 description 4
- 101000668165 Homo sapiens RNA-binding motif, single-stranded-interacting protein 1 Proteins 0.000 description 4
- 101000893674 Homo sapiens Ras GTPase-activating protein-binding protein 2 Proteins 0.000 description 4
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 description 4
- 101000761737 Homo sapiens Ubiquitin-conjugating enzyme E2 L3 Proteins 0.000 description 4
- 101000818532 Homo sapiens Zinc finger and BTB domain-containing protein 20 Proteins 0.000 description 4
- 238000010824 Kaplan-Meier survival analysis Methods 0.000 description 4
- 102100021718 Mitotic checkpoint protein BUB3 Human genes 0.000 description 4
- 102100034217 Non-secretory ribonuclease Human genes 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 102100027330 Phosphoribosylaminoimidazole carboxylase Human genes 0.000 description 4
- 108091000080 Phosphotransferase Proteins 0.000 description 4
- 208000037062 Polyps Diseases 0.000 description 4
- 102000015097 RNA Splicing Factors Human genes 0.000 description 4
- 108010039259 RNA Splicing Factors Proteins 0.000 description 4
- 238000002123 RNA extraction Methods 0.000 description 4
- 102100039692 RNA-binding motif, single-stranded-interacting protein 1 Human genes 0.000 description 4
- 102100040857 Ras GTPase-activating protein-binding protein 2 Human genes 0.000 description 4
- 108010038036 Receptor Activator of Nuclear Factor-kappa B Proteins 0.000 description 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 4
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 4
- 108010006785 Taq Polymerase Proteins 0.000 description 4
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 4
- 102100024861 Ubiquitin-conjugating enzyme E2 L3 Human genes 0.000 description 4
- 102100021146 Zinc finger and BTB domain-containing protein 20 Human genes 0.000 description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 150000001556 benzimidazoles Chemical class 0.000 description 4
- 238000001574 biopsy Methods 0.000 description 4
- 230000034303 cell budding Effects 0.000 description 4
- 230000002950 deficient Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000003046 intermediate neglect of differential overlap Methods 0.000 description 4
- 238000010208 microarray analysis Methods 0.000 description 4
- 230000002438 mitochondrial effect Effects 0.000 description 4
- 102000020233 phosphotransferase Human genes 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 230000003252 repetitive effect Effects 0.000 description 4
- 239000001509 sodium citrate Substances 0.000 description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
- 238000013519 translation Methods 0.000 description 4
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 4
- JVICQEYUDFKRNP-UHFFFAOYSA-N 1h-indol-2-amine;1h-pyrrole Chemical compound C=1C=CNC=1.C1=CC=C2NC(N)=CC2=C1 JVICQEYUDFKRNP-UHFFFAOYSA-N 0.000 description 3
- 102100022644 26S proteasome regulatory subunit 4 Human genes 0.000 description 3
- 102100035988 60S ribosomal protein L39 Human genes 0.000 description 3
- 102100024642 ATP-binding cassette sub-family C member 9 Human genes 0.000 description 3
- 102100030762 Apolipoprotein L1 Human genes 0.000 description 3
- 101150060120 C1qbp gene Proteins 0.000 description 3
- 102100024311 COMM domain-containing protein 2 Human genes 0.000 description 3
- 102100029184 Calmodulin regulator protein PCP4 Human genes 0.000 description 3
- 108020004635 Complementary DNA Proteins 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 102100034560 Cytosol aminopeptidase Human genes 0.000 description 3
- 102100030960 DNA replication licensing factor MCM2 Human genes 0.000 description 3
- 102000016680 Dioxygenases Human genes 0.000 description 3
- 108010028143 Dioxygenases Proteins 0.000 description 3
- 206010061818 Disease progression Diseases 0.000 description 3
- 102100037980 Disks large-associated protein 5 Human genes 0.000 description 3
- 102000001398 Granzyme Human genes 0.000 description 3
- 108060005986 Granzyme Proteins 0.000 description 3
- 102100030386 Granzyme A Human genes 0.000 description 3
- 101000619137 Homo sapiens 26S proteasome regulatory subunit 4 Proteins 0.000 description 3
- 101000760581 Homo sapiens ATP-binding cassette sub-family C member 9 Proteins 0.000 description 3
- 101000909581 Homo sapiens COMM domain-containing protein 2 Proteins 0.000 description 3
- 101000988362 Homo sapiens Calmodulin regulator protein PCP4 Proteins 0.000 description 3
- 101000583807 Homo sapiens DNA replication licensing factor MCM2 Proteins 0.000 description 3
- 101000951365 Homo sapiens Disks large-associated protein 5 Proteins 0.000 description 3
- 101001009599 Homo sapiens Granzyme A Proteins 0.000 description 3
- 101001081176 Homo sapiens Hyaluronan mediated motility receptor Proteins 0.000 description 3
- 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 description 3
- 101001046683 Homo sapiens Integrin alpha-L Proteins 0.000 description 3
- 101001055145 Homo sapiens Interleukin-2 receptor subunit beta Proteins 0.000 description 3
- 101000938676 Homo sapiens Liver carboxylesterase 1 Proteins 0.000 description 3
- 101000869517 Homo sapiens Phosphatidylinositol-3-phosphatase SAC1 Proteins 0.000 description 3
- 101000728117 Homo sapiens Plasma membrane calcium-transporting ATPase 4 Proteins 0.000 description 3
- 101000802948 Homo sapiens Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Proteins 0.000 description 3
- 101001093181 Homo sapiens Short coiled-coil protein Proteins 0.000 description 3
- 101000617830 Homo sapiens Sterol O-acyltransferase 1 Proteins 0.000 description 3
- 101000955100 Homo sapiens WD repeat-containing protein 44 Proteins 0.000 description 3
- 101000976610 Homo sapiens Zinc finger protein 410 Proteins 0.000 description 3
- 102100027735 Hyaluronan mediated motility receptor Human genes 0.000 description 3
- 102100035692 Importin subunit alpha-1 Human genes 0.000 description 3
- 102100032818 Integrin alpha-4 Human genes 0.000 description 3
- 102100022339 Integrin alpha-L Human genes 0.000 description 3
- 102100026879 Interleukin-2 receptor subunit beta Human genes 0.000 description 3
- 102100030817 Liver carboxylesterase 1 Human genes 0.000 description 3
- 108010052285 Membrane Proteins Proteins 0.000 description 3
- 108060004795 Methyltransferase Proteins 0.000 description 3
- 108700020796 Oncogene Proteins 0.000 description 3
- 102000005877 Peptide Initiation Factors Human genes 0.000 description 3
- 108010044843 Peptide Initiation Factors Proteins 0.000 description 3
- 102100028467 Perforin-1 Human genes 0.000 description 3
- 102100032286 Phosphatidylinositol-3-phosphatase SAC1 Human genes 0.000 description 3
- 102100029743 Plasma membrane calcium-transporting ATPase 4 Human genes 0.000 description 3
- 102100024447 Prostaglandin E2 receptor EP3 subtype Human genes 0.000 description 3
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 3
- 102100022851 Rab5 GDP/GTP exchange factor Human genes 0.000 description 3
- 102000004389 Ribonucleoproteins Human genes 0.000 description 3
- 108010081734 Ribonucleoproteins Proteins 0.000 description 3
- 108091006207 SLC-Transporter Proteins 0.000 description 3
- 102000037054 SLC-Transporter Human genes 0.000 description 3
- 102100036292 Short coiled-coil protein Human genes 0.000 description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 102100021993 Sterol O-acyltransferase 1 Human genes 0.000 description 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
- 102100028787 Tumor necrosis factor receptor superfamily member 11A Human genes 0.000 description 3
- 102100038961 WD repeat-containing protein 44 Human genes 0.000 description 3
- 102100023547 Zinc finger protein 410 Human genes 0.000 description 3
- UOYTVCUZCIJKDW-HJZCUYRDSA-N [2-[[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]amino]-1H-imidazol-5-yl]phosphonic acid Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)OC1NC1=NC(P(O)(O)=O)=CN1 UOYTVCUZCIJKDW-HJZCUYRDSA-N 0.000 description 3
- 150000001413 amino acids Chemical group 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229940093530 coenzyme a Drugs 0.000 description 3
- 108010057108 condensin complexes Proteins 0.000 description 3
- 230000002596 correlated effect Effects 0.000 description 3
- 230000005750 disease progression Effects 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000003364 immunohistochemistry Methods 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 108010011989 karyopherin alpha 2 Proteins 0.000 description 3
- 210000001165 lymph node Anatomy 0.000 description 3
- 238000010801 machine learning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 201000001441 melanoma Diseases 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 238000003752 polymerase chain reaction Methods 0.000 description 3
- 102000016914 ras Proteins Human genes 0.000 description 3
- 210000000664 rectum Anatomy 0.000 description 3
- 239000013074 reference sample Substances 0.000 description 3
- 238000010839 reverse transcription Methods 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 238000000528 statistical test Methods 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- 102000003390 tumor necrosis factor Human genes 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 102100036659 26S proteasome non-ATPase regulatory subunit 9 Human genes 0.000 description 2
- 102100023900 3'-5' RNA helicase YTHDC2 Human genes 0.000 description 2
- 102100037563 40S ribosomal protein S2 Human genes 0.000 description 2
- 101150015144 88 gene Proteins 0.000 description 2
- 102100020969 ATP-binding cassette sub-family E member 1 Human genes 0.000 description 2
- 101710159080 Aconitate hydratase A Proteins 0.000 description 2
- 101710159078 Aconitate hydratase B Proteins 0.000 description 2
- 208000003200 Adenoma Diseases 0.000 description 2
- 102100022476 Adenosylhomocysteinase 3 Human genes 0.000 description 2
- 102100022299 All trans-polyprenyl-diphosphate synthase PDSS1 Human genes 0.000 description 2
- 108091093088 Amplicon Proteins 0.000 description 2
- 108010052469 Apolipoprotein L1 Proteins 0.000 description 2
- 102100038110 Arylamine N-acetyltransferase 2 Human genes 0.000 description 2
- 241000972773 Aulopiformes Species 0.000 description 2
- 102000007697 B7-2 Antigen Human genes 0.000 description 2
- 108010021800 B7-2 Antigen Proteins 0.000 description 2
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 2
- 102100022526 Bone morphogenetic protein 5 Human genes 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 101001110283 Canis lupus familiaris Ras-related C3 botulinum toxin substrate 1 Proteins 0.000 description 2
- 102000003846 Carbonic anhydrases Human genes 0.000 description 2
- 108090000209 Carbonic anhydrases Proteins 0.000 description 2
- 108010078791 Carrier Proteins Proteins 0.000 description 2
- 102100038099 Cell division cycle protein 20 homolog Human genes 0.000 description 2
- 102100031214 Centromere protein N Human genes 0.000 description 2
- 108010062745 Chloride Channels Proteins 0.000 description 2
- 102000011045 Chloride Channels Human genes 0.000 description 2
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 description 2
- 102100025191 Cyclin-A2 Human genes 0.000 description 2
- 102100024112 Cyclin-T2 Human genes 0.000 description 2
- 102100035406 Cysteine desulfurase, mitochondrial Human genes 0.000 description 2
- 101710199286 Cytosol aminopeptidase Proteins 0.000 description 2
- 102100037753 DEP domain-containing protein 1A Human genes 0.000 description 2
- 238000000018 DNA microarray Methods 0.000 description 2
- 102100033072 DNA replication ATP-dependent helicase DNA2 Human genes 0.000 description 2
- 101000760085 Daucus carota 21 kDa protein Proteins 0.000 description 2
- AHCYMLUZIRLXAA-SHYZEUOFSA-N Deoxyuridine 5'-triphosphate Chemical compound O1[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C[C@@H]1N1C(=O)NC(=O)C=C1 AHCYMLUZIRLXAA-SHYZEUOFSA-N 0.000 description 2
- 206010061819 Disease recurrence Diseases 0.000 description 2
- 102100021650 ER membrane protein complex subunit 1 Human genes 0.000 description 2
- 102100032670 Endophilin-B1 Human genes 0.000 description 2
- 101000685117 Enteroctopus dofleini S-crystallin 1 Proteins 0.000 description 2
- 108700039887 Essential Genes Proteins 0.000 description 2
- 102100026059 Exosome complex component RRP45 Human genes 0.000 description 2
- 102100033139 Exportin-7 Human genes 0.000 description 2
- 102100035261 FYN-binding protein 1 Human genes 0.000 description 2
- 102100023374 Forkhead box protein M1 Human genes 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 102100025413 Formyltetrahydrofolate synthetase Human genes 0.000 description 2
- 102100032340 G2/mitotic-specific cyclin-B1 Human genes 0.000 description 2
- 102100033201 G2/mitotic-specific cyclin-B2 Human genes 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102100028541 Guanylate-binding protein 2 Human genes 0.000 description 2
- 102100022128 High mobility group protein B2 Human genes 0.000 description 2
- 102100022130 High mobility group protein B3 Human genes 0.000 description 2
- 102100024501 Histone H3-like centromeric protein A Human genes 0.000 description 2
- 101001136710 Homo sapiens 26S proteasome non-ATPase regulatory subunit 9 Proteins 0.000 description 2
- 101000976336 Homo sapiens 3'-5' RNA helicase YTHDC2 Proteins 0.000 description 2
- 101000716179 Homo sapiens 60S ribosomal protein L39 Proteins 0.000 description 2
- 101000783786 Homo sapiens ATP-binding cassette sub-family E member 1 Proteins 0.000 description 2
- 101000884399 Homo sapiens Arylamine N-acetyltransferase 2 Proteins 0.000 description 2
- 101001023837 Homo sapiens Cysteine desulfurase, mitochondrial Proteins 0.000 description 2
- 101000950642 Homo sapiens DEP domain-containing protein 1A Proteins 0.000 description 2
- 101000927313 Homo sapiens DNA replication ATP-dependent helicase DNA2 Proteins 0.000 description 2
- 101001018431 Homo sapiens DNA replication licensing factor MCM7 Proteins 0.000 description 2
- 101000896333 Homo sapiens ER membrane protein complex subunit 1 Proteins 0.000 description 2
- 101000781458 Homo sapiens Exportin-7 Proteins 0.000 description 2
- 101001022163 Homo sapiens FYN-binding protein 1 Proteins 0.000 description 2
- 101001045791 Homo sapiens High mobility group protein B2 Proteins 0.000 description 2
- 101001045794 Homo sapiens High mobility group protein B3 Proteins 0.000 description 2
- 101001015059 Homo sapiens Integrin beta-5 Proteins 0.000 description 2
- 101000971797 Homo sapiens KH homology domain-containing protein 4 Proteins 0.000 description 2
- 101001139117 Homo sapiens Krueppel-like factor 7 Proteins 0.000 description 2
- 101001018097 Homo sapiens L-selectin Proteins 0.000 description 2
- 101001000302 Homo sapiens Max-interacting protein 1 Proteins 0.000 description 2
- 101000896657 Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 Proteins 0.000 description 2
- 101001108926 Homo sapiens Nuclear pore complex protein Nup160 Proteins 0.000 description 2
- 101000693243 Homo sapiens Paternally-expressed gene 3 protein Proteins 0.000 description 2
- 101000987581 Homo sapiens Perforin-1 Proteins 0.000 description 2
- 101000887199 Homo sapiens Polyamine-transporting ATPase 13A3 Proteins 0.000 description 2
- 101001015936 Homo sapiens Probable rRNA-processing protein EBP2 Proteins 0.000 description 2
- 101001117517 Homo sapiens Prostaglandin E2 receptor EP3 subtype Proteins 0.000 description 2
- 101000597932 Homo sapiens Protein numb homolog Proteins 0.000 description 2
- 101000919980 Homo sapiens Protoheme IX farnesyltransferase, mitochondrial Proteins 0.000 description 2
- 101001077400 Homo sapiens Ras-related protein Rab-6A Proteins 0.000 description 2
- 101000582412 Homo sapiens Replication factor C subunit 5 Proteins 0.000 description 2
- 101000654257 Homo sapiens SCY1-like protein 2 Proteins 0.000 description 2
- 101000609920 Homo sapiens Sister chromatid cohesion protein PDS5 homolog A Proteins 0.000 description 2
- 101000689199 Homo sapiens Src-like-adapter Proteins 0.000 description 2
- 101000633445 Homo sapiens Structural maintenance of chromosomes protein 2 Proteins 0.000 description 2
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 description 2
- 101000738335 Homo sapiens T-cell surface glycoprotein CD3 zeta chain Proteins 0.000 description 2
- 101000838456 Homo sapiens Tubulin alpha-1B chain Proteins 0.000 description 2
- 101000954800 Homo sapiens WD repeat domain phosphoinositide-interacting protein 3 Proteins 0.000 description 2
- 101000782174 Homo sapiens WD repeat-containing protein 82 Proteins 0.000 description 2
- 101000781876 Homo sapiens Zinc finger protein 518A Proteins 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 102100034415 Inorganic pyrophosphatase 2, mitochondrial Human genes 0.000 description 2
- 102100033010 Integrin beta-5 Human genes 0.000 description 2
- 102100036981 Interferon regulatory factor 1 Human genes 0.000 description 2
- 102100021449 KH homology domain-containing protein 4 Human genes 0.000 description 2
- 102100020692 Krueppel-like factor 7 Human genes 0.000 description 2
- 102100033467 L-selectin Human genes 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 206010024612 Lipoma Diseases 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 102000018697 Membrane Proteins Human genes 0.000 description 2
- 102000016397 Methyltransferase Human genes 0.000 description 2
- 102100021691 Mitotic checkpoint serine/threonine-protein kinase BUB1 Human genes 0.000 description 2
- 102100035971 Molybdopterin molybdenumtransferase Human genes 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 238000000636 Northern blotting Methods 0.000 description 2
- 102100021510 Nuclear pore complex protein Nup160 Human genes 0.000 description 2
- 102100025372 Nuclear pore complex protein Nup98-Nup96 Human genes 0.000 description 2
- 108090000163 Nuclear pore complex proteins Proteins 0.000 description 2
- 102100037826 Nucleoporin NDC1 Human genes 0.000 description 2
- BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 description 2
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 2
- 108010038807 Oligopeptides Proteins 0.000 description 2
- 102000015636 Oligopeptides Human genes 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 102000025443 POZ domain binding proteins Human genes 0.000 description 2
- 108091014659 POZ domain binding proteins Proteins 0.000 description 2
- 101150117667 PPP1R14D gene Proteins 0.000 description 2
- 102100025757 Paternally-expressed gene 3 protein Human genes 0.000 description 2
- 102100038809 Peptidyl-prolyl cis-trans isomerase FKBP9 Human genes 0.000 description 2
- 102100034850 Peptidyl-prolyl cis-trans isomerase G Human genes 0.000 description 2
- 108010064209 Phosphoribosylglycinamide formyltransferase Proteins 0.000 description 2
- 102100039916 Polyamine-transporting ATPase 13A3 Human genes 0.000 description 2
- 208000008691 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 2
- 102100032223 Probable rRNA-processing protein EBP2 Human genes 0.000 description 2
- 102000001253 Protein Kinase Human genes 0.000 description 2
- 102100036985 Protein numb homolog Human genes 0.000 description 2
- 102100024202 Protein phosphatase 1 regulatory subunit 14D Human genes 0.000 description 2
- 102100038675 Protein phosphatase 1D Human genes 0.000 description 2
- 102100030729 Protoheme IX farnesyltransferase, mitochondrial Human genes 0.000 description 2
- 102100027511 RANBP2-like and GRIP domain-containing protein 2 Human genes 0.000 description 2
- 102100027504 RANBP2-like and GRIP domain-containing protein 8 Human genes 0.000 description 2
- 238000010802 RNA extraction kit Methods 0.000 description 2
- 239000013614 RNA sample Substances 0.000 description 2
- 102000044126 RNA-Binding Proteins Human genes 0.000 description 2
- 101710105008 RNA-binding protein Proteins 0.000 description 2
- 102100025219 Ras-related protein Rab-6A Human genes 0.000 description 2
- 208000015634 Rectal Neoplasms Diseases 0.000 description 2
- 102000018779 Replication Protein C Human genes 0.000 description 2
- 108010027647 Replication Protein C Proteins 0.000 description 2
- 102100030541 Replication factor C subunit 5 Human genes 0.000 description 2
- 101710203837 Replication-associated protein Proteins 0.000 description 2
- 201000000582 Retinoblastoma Diseases 0.000 description 2
- 108010083644 Ribonucleases Proteins 0.000 description 2
- 102000006382 Ribonucleases Human genes 0.000 description 2
- 102100031698 SCY1-like protein 2 Human genes 0.000 description 2
- 102100029214 SLAM family member 8 Human genes 0.000 description 2
- 108091006629 SLC13A2 Proteins 0.000 description 2
- 102100035728 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Human genes 0.000 description 2
- 108020004682 Single-Stranded DNA Proteins 0.000 description 2
- 102100039166 Sister chromatid cohesion protein PDS5 homolog A Human genes 0.000 description 2
- 102100032929 Son of sevenless homolog 1 Human genes 0.000 description 2
- 102100030435 Sp110 nuclear body protein Human genes 0.000 description 2
- 102100021915 Sperm-associated antigen 5 Human genes 0.000 description 2
- 102100024519 Src-like-adapter Human genes 0.000 description 2
- 108010039445 Stem Cell Factor Proteins 0.000 description 2
- 108010090804 Streptavidin Proteins 0.000 description 2
- 102100029540 Structural maintenance of chromosomes protein 2 Human genes 0.000 description 2
- 108010002687 Survivin Proteins 0.000 description 2
- 102100035604 Synaptopodin Human genes 0.000 description 2
- 102100038721 T-box transcription factor TBX2 Human genes 0.000 description 2
- 102100027208 T-cell antigen CD7 Human genes 0.000 description 2
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 description 2
- 102100037906 T-cell surface glycoprotein CD3 zeta chain Human genes 0.000 description 2
- 102100035101 Transcription factor 7-like 2 Human genes 0.000 description 2
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 description 2
- 102000004243 Tubulin Human genes 0.000 description 2
- 108090000704 Tubulin Proteins 0.000 description 2
- 102100028969 Tubulin alpha-1B chain Human genes 0.000 description 2
- 102100037932 Ubiquitin D Human genes 0.000 description 2
- 102100029779 Ubiquitin-associated protein 1 Human genes 0.000 description 2
- 102100037049 WD repeat domain phosphoinositide-interacting protein 3 Human genes 0.000 description 2
- 102100036550 WD repeat-containing protein 82 Human genes 0.000 description 2
- 102100022222 Y-box-binding protein 2 Human genes 0.000 description 2
- 102100023442 Zinc finger protein 148 Human genes 0.000 description 2
- 102100028422 Zinc finger protein 304 Human genes 0.000 description 2
- 102100024719 Zinc finger protein 345 Human genes 0.000 description 2
- 102100036690 Zinc finger protein 518A Human genes 0.000 description 2
- 102100040803 Zymogen granule membrane protein 16 Human genes 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 208000009956 adenocarcinoma Diseases 0.000 description 2
- 238000000540 analysis of variance Methods 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 238000013473 artificial intelligence Methods 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 102100035161 c-Myc-binding protein Human genes 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 238000004422 calculation algorithm Methods 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 230000021164 cell adhesion Effects 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000022131 cell cycle Effects 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 239000002975 chemoattractant Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 201000007571 cloacogenic carcinoma Diseases 0.000 description 2
- 238000007621 cluster analysis Methods 0.000 description 2
- 239000005516 coenzyme A Substances 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 229950006137 dexfosfoserine Drugs 0.000 description 2
- 229960000633 dextran sulfate Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 238000010195 expression analysis Methods 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 238000011223 gene expression profiling Methods 0.000 description 2
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
- 229940099552 hyaluronan Drugs 0.000 description 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000004807 localization Effects 0.000 description 2
- 238000001325 log-rank test Methods 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 238000010841 mRNA extraction Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000036456 mitotic arrest Effects 0.000 description 2
- 238000010369 molecular cloning Methods 0.000 description 2
- 230000004899 motility Effects 0.000 description 2
- 230000009826 neoplastic cell growth Effects 0.000 description 2
- 239000002751 oligonucleotide probe Substances 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 2
- 238000007781 pre-processing Methods 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- 108060006633 protein kinase Proteins 0.000 description 2
- 230000000171 quenching effect Effects 0.000 description 2
- 108010014186 ras Proteins Proteins 0.000 description 2
- 238000010188 recombinant method Methods 0.000 description 2
- 235000019515 salmon Nutrition 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 230000009897 systematic effect Effects 0.000 description 2
- 210000001550 testis Anatomy 0.000 description 2
- 230000001131 transforming effect Effects 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- NFBQIWJDUKFHJP-SQOUGZDYSA-N (2r,3s,4r,5r)-3,4,5,6-tetrahydroxy-2-phosphonooxyhexanoic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](C(O)=O)OP(O)(O)=O NFBQIWJDUKFHJP-SQOUGZDYSA-N 0.000 description 1
- NWGZOALPWZDXNG-LURJTMIESA-N (2s)-5-(diaminomethylideneamino)-2-(dimethylamino)pentanoic acid Chemical compound CN(C)[C@H](C(O)=O)CCCNC(N)=N NWGZOALPWZDXNG-LURJTMIESA-N 0.000 description 1
- PJOHVEQSYPOERL-SHEAVXILSA-N (e)-n-[(4r,4as,7ar,12br)-3-(cyclopropylmethyl)-9-hydroxy-7-oxo-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-4a-yl]-3-(4-methylphenyl)prop-2-enamide Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)N[C@]1(CCC(=O)[C@@H]2O3)[C@H]4CC5=CC=C(O)C3=C5[C@]12CCN4CC1CC1 PJOHVEQSYPOERL-SHEAVXILSA-N 0.000 description 1
- 101150084750 1 gene Proteins 0.000 description 1
- 101150066838 12 gene Proteins 0.000 description 1
- CKTSBUTUHBMZGZ-SHYZEUOFSA-N 2'‐deoxycytidine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 CKTSBUTUHBMZGZ-SHYZEUOFSA-N 0.000 description 1
- KXSKAZFMTGADIV-UHFFFAOYSA-N 2-[3-(2-hydroxyethoxy)propoxy]ethanol Chemical compound OCCOCCCOCCO KXSKAZFMTGADIV-UHFFFAOYSA-N 0.000 description 1
- 101710186725 2-acylglycerol O-acyltransferase 2 Proteins 0.000 description 1
- KZMAWJRXKGLWGS-UHFFFAOYSA-N 2-chloro-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-n-(3-methoxypropyl)acetamide Chemical compound S1C(N(C(=O)CCl)CCCOC)=NC(C=2C=CC(OC)=CC=2)=C1 KZMAWJRXKGLWGS-UHFFFAOYSA-N 0.000 description 1
- PMWATMXOQQZNBX-DKBZLLMOSA-N 2-methylcrotonoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(/C)=C/C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 PMWATMXOQQZNBX-DKBZLLMOSA-N 0.000 description 1
- 101150033839 4 gene Proteins 0.000 description 1
- QYNUQALWYRSVHF-ABLWVSNPSA-N 5,10-methylenetetrahydrofolic acid Chemical compound C1N2C=3C(=O)NC(N)=NC=3NCC2CN1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QYNUQALWYRSVHF-ABLWVSNPSA-N 0.000 description 1
- 101150039504 6 gene Proteins 0.000 description 1
- OQRXBXNATIHDQO-UHFFFAOYSA-N 6-chloropyridine-3,4-diamine Chemical compound NC1=CN=C(Cl)C=C1N OQRXBXNATIHDQO-UHFFFAOYSA-N 0.000 description 1
- 101150030286 71 gene Proteins 0.000 description 1
- 101150026888 84 gene Proteins 0.000 description 1
- 101150055707 98 gene Proteins 0.000 description 1
- 102100039900 ADP-ribosylation factor 6 Human genes 0.000 description 1
- 102100040190 ADP-ribosylation factor-binding protein GGA2 Human genes 0.000 description 1
- 102100033938 AP-1 complex subunit gamma-1 Human genes 0.000 description 1
- 102100034481 AP-1 complex-associated regulatory protein Human genes 0.000 description 1
- 108010004483 APOBEC-3G Deaminase Proteins 0.000 description 1
- 102100023388 ATP-dependent RNA helicase DHX15 Human genes 0.000 description 1
- 108091006112 ATPases Proteins 0.000 description 1
- 102100022117 Abnormal spindle-like microcephaly-associated protein Human genes 0.000 description 1
- 108010005254 Activating Transcription Factors Proteins 0.000 description 1
- 102000005869 Activating Transcription Factors Human genes 0.000 description 1
- 206010001233 Adenoma benign Diseases 0.000 description 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 1
- 101710187713 Adenosylhomocysteinase 3 Proteins 0.000 description 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 101710188695 Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 description 1
- 102100024296 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Human genes 0.000 description 1
- 108091029845 Aminoallyl nucleotide Proteins 0.000 description 1
- 206010059313 Anogenital warts Diseases 0.000 description 1
- 102100030343 Antigen peptide transporter 2 Human genes 0.000 description 1
- 208000007860 Anus Neoplasms Diseases 0.000 description 1
- 101710095342 Apolipoprotein B Proteins 0.000 description 1
- 102100040202 Apolipoprotein B-100 Human genes 0.000 description 1
- 102100030766 Apolipoprotein L3 Human genes 0.000 description 1
- 101100389644 Arabidopsis thaliana ERF8 gene Proteins 0.000 description 1
- 101100125899 Arabidopsis thaliana ILK1 gene Proteins 0.000 description 1
- 101100404726 Arabidopsis thaliana NHX7 gene Proteins 0.000 description 1
- 101100465057 Arabidopsis thaliana PRK2 gene Proteins 0.000 description 1
- 101100048046 Arabidopsis thaliana UGT84A2 gene Proteins 0.000 description 1
- 102100023245 Asparagine-tRNA ligase, cytoplasmic Human genes 0.000 description 1
- 102000003924 Asparagine-tRNA ligases Human genes 0.000 description 1
- 108090000314 Asparagine-tRNA ligases Proteins 0.000 description 1
- 241000713838 Avian myeloblastosis virus Species 0.000 description 1
- 102100032430 B-cell CLL/lymphoma 7 protein family member C Human genes 0.000 description 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
- 108700020463 BRCA1 Proteins 0.000 description 1
- 101150072950 BRCA1 gene Proteins 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 108010049976 Bone Morphogenetic Protein 5 Proteins 0.000 description 1
- 102100024486 Borealin Human genes 0.000 description 1
- 101100237637 Bos taurus APOL gene Proteins 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 208000013165 Bowen disease Diseases 0.000 description 1
- 208000019337 Bowen disease of the skin Diseases 0.000 description 1
- 102100025401 Breast cancer type 1 susceptibility protein Human genes 0.000 description 1
- 102000001805 Bromodomains Human genes 0.000 description 1
- 108050009021 Bromodomains Proteins 0.000 description 1
- 102100027156 Butyrophilin subfamily 2 member A2 Human genes 0.000 description 1
- 102100027154 Butyrophilin subfamily 3 member A3 Human genes 0.000 description 1
- 108010017533 Butyrophilins Proteins 0.000 description 1
- 102000004555 Butyrophilins Human genes 0.000 description 1
- 102100032367 C-C motif chemokine 5 Human genes 0.000 description 1
- 108090000342 C-Type Lectins Proteins 0.000 description 1
- 102000003930 C-Type Lectins Human genes 0.000 description 1
- 102100026197 C-type lectin domain family 2 member D Human genes 0.000 description 1
- 102000010910 CD28 Antigens Human genes 0.000 description 1
- 108010062433 CD28 Antigens Proteins 0.000 description 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 1
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 1
- 108700020472 CDC20 Proteins 0.000 description 1
- 101150047144 CDC28 gene Proteins 0.000 description 1
- 101150018198 COX1 gene Proteins 0.000 description 1
- 101150043980 COXI gene Proteins 0.000 description 1
- 108090000312 Calcium Channels Proteins 0.000 description 1
- 102000003922 Calcium Channels Human genes 0.000 description 1
- 102100039901 Calcyclin-binding protein Human genes 0.000 description 1
- 101710194360 Calcyclin-binding protein Proteins 0.000 description 1
- 102000000584 Calmodulin Human genes 0.000 description 1
- 108010041952 Calmodulin Proteins 0.000 description 1
- 108090000489 Carboxy-Lyases Proteins 0.000 description 1
- 208000009458 Carcinoma in Situ Diseases 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010076667 Caspases Proteins 0.000 description 1
- 102000011727 Caspases Human genes 0.000 description 1
- 108090000624 Cathepsin L Proteins 0.000 description 1
- 102400001321 Cathepsin L Human genes 0.000 description 1
- 108090000613 Cathepsin S Proteins 0.000 description 1
- 101150023302 Cdc20 gene Proteins 0.000 description 1
- 102000011068 Cdc42 Human genes 0.000 description 1
- 102100027835 Cell death regulator Aven Human genes 0.000 description 1
- 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 description 1
- 108010076303 Centromere Protein A Proteins 0.000 description 1
- 101710084071 Centromere protein N Proteins 0.000 description 1
- 102100034790 Centrosomal protein of 76 kDa Human genes 0.000 description 1
- 102100035696 Centrosome-associated protein 350 Human genes 0.000 description 1
- 101710101089 Centrosome-associated protein 350 Proteins 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 241000195585 Chlamydomonas Species 0.000 description 1
- 241000251730 Chondrichthyes Species 0.000 description 1
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 1
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 1
- 102000008868 Chromatin Assembly Factor-1 Human genes 0.000 description 1
- 108010088529 Chromatin Assembly Factor-1 Proteins 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 108091005769 Clathrin adaptor proteins Proteins 0.000 description 1
- 102000035183 Clathrin adaptor proteins Human genes 0.000 description 1
- 241000252203 Clupea harengus Species 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 102100023755 Coiled-coil domain-containing protein 192 Human genes 0.000 description 1
- 102100034953 Coiled-coil domain-containing protein 68 Human genes 0.000 description 1
- 102100032355 Coiled-coil domain-containing protein 92 Human genes 0.000 description 1
- 206010048832 Colon adenoma Diseases 0.000 description 1
- 102000016917 Complement C1 Human genes 0.000 description 1
- 108010028774 Complement C1 Proteins 0.000 description 1
- 102100032952 Condensin complex subunit 3 Human genes 0.000 description 1
- 206010053138 Congenital aplastic anaemia Diseases 0.000 description 1
- 101000785223 Crocosmia x crocosmiiflora Myricetin 3-O-glucosyl 1,2-rhamnoside 6'-O-caffeoyltransferase AT1 Proteins 0.000 description 1
- 102000052581 Cullin Human genes 0.000 description 1
- 108700020475 Cullin Proteins 0.000 description 1
- 102100023583 Cyclic AMP-dependent transcription factor ATF-6 alpha Human genes 0.000 description 1
- 102000016736 Cyclin Human genes 0.000 description 1
- 108050006400 Cyclin Proteins 0.000 description 1
- 108010060273 Cyclin A2 Proteins 0.000 description 1
- 108010060385 Cyclin B1 Proteins 0.000 description 1
- 108010060387 Cyclin B2 Proteins 0.000 description 1
- 108010068106 Cyclin T Proteins 0.000 description 1
- 108010017222 Cyclin-Dependent Kinase Inhibitor p57 Proteins 0.000 description 1
- 102000004480 Cyclin-Dependent Kinase Inhibitor p57 Human genes 0.000 description 1
- 102100034770 Cyclin-dependent kinase inhibitor 3 Human genes 0.000 description 1
- 101710157591 Cyclin-dependent kinase inhibitor 3 Proteins 0.000 description 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 description 1
- 102000003903 Cyclin-dependent kinases Human genes 0.000 description 1
- 102100032522 Cyclin-dependent kinases regulatory subunit 2 Human genes 0.000 description 1
- 101710173551 Cysteine proteinase 1, mitochondrial Proteins 0.000 description 1
- 102100030878 Cytochrome c oxidase subunit 1 Human genes 0.000 description 1
- 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 1
- 108090000365 Cytochrome-c oxidases Proteins 0.000 description 1
- 102100038076 DNA dC->dU-editing enzyme APOBEC-3G Human genes 0.000 description 1
- 102100039524 DNA endonuclease RBBP8 Human genes 0.000 description 1
- 102100024829 DNA polymerase delta catalytic subunit Human genes 0.000 description 1
- 102100029910 DNA polymerase epsilon subunit 2 Human genes 0.000 description 1
- 239000003155 DNA primer Substances 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 102100033587 DNA topoisomerase 2-alpha Human genes 0.000 description 1
- 102000052510 DNA-Binding Proteins Human genes 0.000 description 1
- 101710096438 DNA-binding protein Proteins 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 102100021790 Delta-sarcoglycan Human genes 0.000 description 1
- CKTSBUTUHBMZGZ-UHFFFAOYSA-N Deoxycytidine Natural products O=C1N=C(N)C=CN1C1OC(CO)C(O)C1 CKTSBUTUHBMZGZ-UHFFFAOYSA-N 0.000 description 1
- 102100030074 Dickkopf-related protein 1 Human genes 0.000 description 1
- 101100011517 Drosophila melanogaster ELOVL gene Proteins 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 102100023274 Dual specificity mitogen-activated protein kinase kinase 4 Human genes 0.000 description 1
- 102100036109 Dual specificity protein kinase TTK Human genes 0.000 description 1
- 102100024827 Dynamin-1-like protein Human genes 0.000 description 1
- 108010069091 Dystrophin Proteins 0.000 description 1
- 102000001039 Dystrophin Human genes 0.000 description 1
- 102100021766 E3 ubiquitin-protein ligase RNF138 Human genes 0.000 description 1
- 101710162546 E3 ubiquitin-protein ligase RNF138 Proteins 0.000 description 1
- 102100038662 E3 ubiquitin-protein ligase SMURF2 Human genes 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102100039249 Elongation of very long chain fatty acids protein 6 Human genes 0.000 description 1
- 108050007786 Elongation of very long chain fatty acids protein 6 Proteins 0.000 description 1
- 101000600890 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) G2-specific protein kinase nimA Proteins 0.000 description 1
- 101710180995 Endonuclease 1 Proteins 0.000 description 1
- 102100027847 Endonuclease ZRANB3 Human genes 0.000 description 1
- 101710082519 Endonuclease ZRANB3 Proteins 0.000 description 1
- 108010042407 Endonucleases Proteins 0.000 description 1
- 101710197295 Endophilin-B1 Proteins 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 102100039607 Erlin-1 Human genes 0.000 description 1
- 101710201312 Ethanolamine kinase 1 Proteins 0.000 description 1
- 101710120484 Exosome complex component RRP45 Proteins 0.000 description 1
- 208000010368 Extramammary Paget Disease Diseases 0.000 description 1
- 108010066805 F-Box Proteins Proteins 0.000 description 1
- 102000018700 F-Box Proteins Human genes 0.000 description 1
- 102100024516 F-box only protein 5 Human genes 0.000 description 1
- 102100039837 F-box/LRR-repeat protein 14 Human genes 0.000 description 1
- 101150064015 FAS gene Proteins 0.000 description 1
- 201000004939 Fanconi anemia Diseases 0.000 description 1
- 102100031106 Fatty acid hydroxylase domain-containing protein 2 Human genes 0.000 description 1
- 101150111119 Fem1c gene Proteins 0.000 description 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 description 1
- 240000008168 Ficus benjamina Species 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 108010008599 Forkhead Box Protein M1 Proteins 0.000 description 1
- 108010080982 Formate-tetrahydrofolate ligase Proteins 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- 102100025361 G-protein coupled receptor 161 Human genes 0.000 description 1
- 102000019448 GART Human genes 0.000 description 1
- 102000013446 GTP Phosphohydrolases Human genes 0.000 description 1
- 102100037880 GTP-binding protein REM 1 Human genes 0.000 description 1
- 108091006109 GTPases Proteins 0.000 description 1
- 102100040510 Galectin-3-binding protein Human genes 0.000 description 1
- 108010010038 Gamma-protocadherins Proteins 0.000 description 1
- 208000000321 Gardner Syndrome Diseases 0.000 description 1
- 206010064571 Gene mutation Diseases 0.000 description 1
- 241000976806 Genea <ascomycete fungus> Species 0.000 description 1
- 102100036530 General transcription factor 3C polypeptide 4 Human genes 0.000 description 1
- 102100032864 General transcription factor IIH subunit 2 Human genes 0.000 description 1
- 102100033264 Geranylgeranyl transferase type-1 subunit beta Human genes 0.000 description 1
- 102000004038 Glia Maturation Factor Human genes 0.000 description 1
- 108090000495 Glia Maturation Factor Proteins 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 108010056771 Glucosidases Proteins 0.000 description 1
- 102000004366 Glucosidases Human genes 0.000 description 1
- 101710104589 Guanine nucleotide exchange factor MSS4 Proteins 0.000 description 1
- 101710110789 Guanylate-binding protein 2 Proteins 0.000 description 1
- 102100028543 Guanylate-binding protein 3 Human genes 0.000 description 1
- 102100039335 HAUS augmin-like complex subunit 5 Human genes 0.000 description 1
- 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 description 1
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 description 1
- 102100033079 HLA class II histocompatibility antigen, DM alpha chain Human genes 0.000 description 1
- 102100040505 HLA class II histocompatibility antigen, DR alpha chain Human genes 0.000 description 1
- 108010050568 HLA-DM antigens Proteins 0.000 description 1
- 108010067802 HLA-DR alpha-Chains Proteins 0.000 description 1
- 208000002927 Hamartoma Diseases 0.000 description 1
- 102000008015 Hemeproteins Human genes 0.000 description 1
- 108010020382 Hepatocyte Nuclear Factor 1-alpha Proteins 0.000 description 1
- 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 description 1
- 102100027706 Heterogeneous nuclear ribonucleoprotein D-like Human genes 0.000 description 1
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 description 1
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 1
- 102100023919 Histone H2A.Z Human genes 0.000 description 1
- 102100021467 Histone acetyltransferase type B catalytic subunit Human genes 0.000 description 1
- 108010033040 Histones Proteins 0.000 description 1
- 102100030234 Homeobox protein cut-like 1 Human genes 0.000 description 1
- 101001098029 Homo sapiens 40S ribosomal protein S2 Proteins 0.000 description 1
- 101000684275 Homo sapiens ADP-ribosylation factor 3 Proteins 0.000 description 1
- 101001037082 Homo sapiens ADP-ribosylation factor-binding protein GGA2 Proteins 0.000 description 1
- 101000779234 Homo sapiens AP-1 complex subunit gamma-1 Proteins 0.000 description 1
- 101000779216 Homo sapiens AP-1 complex-associated regulatory protein Proteins 0.000 description 1
- 101100323521 Homo sapiens APOL1 gene Proteins 0.000 description 1
- 101000907886 Homo sapiens ATP-dependent RNA helicase DHX15 Proteins 0.000 description 1
- 101000900939 Homo sapiens Abnormal spindle-like microcephaly-associated protein Proteins 0.000 description 1
- 101000822527 Homo sapiens Adenosylhomocysteinase 3 Proteins 0.000 description 1
- 101000902409 Homo sapiens All trans-polyprenyl-diphosphate synthase PDSS1 Proteins 0.000 description 1
- 101000793443 Homo sapiens Apolipoprotein L3 Proteins 0.000 description 1
- 101000624939 Homo sapiens Asparagine-tRNA ligase, cytoplasmic Proteins 0.000 description 1
- 101000798476 Homo sapiens B-cell CLL/lymphoma 7 protein family member C Proteins 0.000 description 1
- 101000899388 Homo sapiens Bone morphogenetic protein 5 Proteins 0.000 description 1
- 101000762405 Homo sapiens Borealin Proteins 0.000 description 1
- 101000984925 Homo sapiens Butyrophilin subfamily 2 member A2 Proteins 0.000 description 1
- 101000984916 Homo sapiens Butyrophilin subfamily 3 member A3 Proteins 0.000 description 1
- 101000978381 Homo sapiens C-C motif chemokine 14 Proteins 0.000 description 1
- 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 description 1
- 101000912615 Homo sapiens C-type lectin domain family 2 member D Proteins 0.000 description 1
- 101000698131 Homo sapiens Cell death regulator Aven Proteins 0.000 description 1
- 101000884317 Homo sapiens Cell division cycle protein 20 homolog Proteins 0.000 description 1
- 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 description 1
- 101000776412 Homo sapiens Centromere protein N Proteins 0.000 description 1
- 101000945840 Homo sapiens Centrosomal protein of 76 kDa Proteins 0.000 description 1
- 101000978235 Homo sapiens Coiled-coil domain-containing protein 192 Proteins 0.000 description 1
- 101000946607 Homo sapiens Coiled-coil domain-containing protein 68 Proteins 0.000 description 1
- 101000797732 Homo sapiens Coiled-coil domain-containing protein 92 Proteins 0.000 description 1
- 101000710846 Homo sapiens Condensin complex subunit 1 Proteins 0.000 description 1
- 101000942622 Homo sapiens Condensin complex subunit 3 Proteins 0.000 description 1
- 101000905751 Homo sapiens Cyclic AMP-dependent transcription factor ATF-6 alpha Proteins 0.000 description 1
- 101000934320 Homo sapiens Cyclin-A2 Proteins 0.000 description 1
- 101000910484 Homo sapiens Cyclin-T2 Proteins 0.000 description 1
- 101000868333 Homo sapiens Cyclin-dependent kinase 1 Proteins 0.000 description 1
- 101000942317 Homo sapiens Cyclin-dependent kinases regulatory subunit 2 Proteins 0.000 description 1
- 101000924389 Homo sapiens Cytosol aminopeptidase Proteins 0.000 description 1
- 101000746134 Homo sapiens DNA endonuclease RBBP8 Proteins 0.000 description 1
- 101000909198 Homo sapiens DNA polymerase delta catalytic subunit Proteins 0.000 description 1
- 101000864190 Homo sapiens DNA polymerase epsilon subunit 2 Proteins 0.000 description 1
- 101000616408 Homo sapiens Delta-sarcoglycan Proteins 0.000 description 1
- 101000864646 Homo sapiens Dickkopf-related protein 1 Proteins 0.000 description 1
- 101001115395 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Proteins 0.000 description 1
- 101000659223 Homo sapiens Dual specificity protein kinase TTK Proteins 0.000 description 1
- 101000909218 Homo sapiens Dynamin-1-like protein Proteins 0.000 description 1
- 101000664952 Homo sapiens E3 ubiquitin-protein ligase SMURF2 Proteins 0.000 description 1
- 101000654648 Homo sapiens Endophilin-B1 Proteins 0.000 description 1
- 101000814010 Homo sapiens Erlin-1 Proteins 0.000 description 1
- 101001055965 Homo sapiens Exosome complex component RRP45 Proteins 0.000 description 1
- 101001052797 Homo sapiens F-box only protein 5 Proteins 0.000 description 1
- 101000885595 Homo sapiens F-box/LRR-repeat protein 14 Proteins 0.000 description 1
- 101001066086 Homo sapiens Fatty acid hydroxylase domain-containing protein 2 Proteins 0.000 description 1
- 101000907578 Homo sapiens Forkhead box protein M1 Proteins 0.000 description 1
- 101000857756 Homo sapiens G-protein coupled receptor 161 Proteins 0.000 description 1
- 101000868643 Homo sapiens G2/mitotic-specific cyclin-B1 Proteins 0.000 description 1
- 101000713023 Homo sapiens G2/mitotic-specific cyclin-B2 Proteins 0.000 description 1
- 101001095995 Homo sapiens GTP-binding protein REM 1 Proteins 0.000 description 1
- 101000967904 Homo sapiens Galectin-3-binding protein Proteins 0.000 description 1
- 101000714252 Homo sapiens General transcription factor 3C polypeptide 4 Proteins 0.000 description 1
- 101000655398 Homo sapiens General transcription factor IIH subunit 2 Proteins 0.000 description 1
- 101001071129 Homo sapiens Geranylgeranyl transferase type-1 subunit beta Proteins 0.000 description 1
- 101001058858 Homo sapiens Guanylate-binding protein 2 Proteins 0.000 description 1
- 101001035821 Homo sapiens HAUS augmin-like complex subunit 5 Proteins 0.000 description 1
- 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 description 1
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 description 1
- 101001081145 Homo sapiens Heterogeneous nuclear ribonucleoprotein D-like Proteins 0.000 description 1
- 101000905054 Homo sapiens Histone H2A.Z Proteins 0.000 description 1
- 101000981071 Homo sapiens Histone H3-like centromeric protein A Proteins 0.000 description 1
- 101000726740 Homo sapiens Homeobox protein cut-like 1 Proteins 0.000 description 1
- 101001083553 Homo sapiens Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Proteins 0.000 description 1
- 101000994880 Homo sapiens Inorganic pyrophosphatase 2, mitochondrial Proteins 0.000 description 1
- 101000598002 Homo sapiens Interferon regulatory factor 1 Proteins 0.000 description 1
- 101000833614 Homo sapiens Interferon-inducible protein AIM2 Proteins 0.000 description 1
- 101001008953 Homo sapiens Kinesin-like protein KIF11 Proteins 0.000 description 1
- 101001008951 Homo sapiens Kinesin-like protein KIF15 Proteins 0.000 description 1
- 101001091231 Homo sapiens Kinesin-like protein KIF18A Proteins 0.000 description 1
- 101000605743 Homo sapiens Kinesin-like protein KIF23 Proteins 0.000 description 1
- 101001138020 Homo sapiens La-related protein 4 Proteins 0.000 description 1
- 101001039207 Homo sapiens Low-density lipoprotein receptor-related protein 8 Proteins 0.000 description 1
- 101001039035 Homo sapiens Lutropin-choriogonadotropic hormone receptor Proteins 0.000 description 1
- 101001090688 Homo sapiens Lymphocyte cytosolic protein 2 Proteins 0.000 description 1
- 101001051291 Homo sapiens Lysosomal-associated transmembrane protein 5 Proteins 0.000 description 1
- 101000634835 Homo sapiens M1-specific T cell receptor alpha chain Proteins 0.000 description 1
- 101000763322 Homo sapiens M1-specific T cell receptor beta chain Proteins 0.000 description 1
- 101000969581 Homo sapiens MOB kinase activator 1A Proteins 0.000 description 1
- 101000581533 Homo sapiens Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Proteins 0.000 description 1
- 101000794228 Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Proteins 0.000 description 1
- 101001074975 Homo sapiens Molybdopterin molybdenumtransferase Proteins 0.000 description 1
- 101000866805 Homo sapiens Non-histone chromosomal protein HMG-17 Proteins 0.000 description 1
- 101000663003 Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Proteins 0.000 description 1
- 101001121654 Homo sapiens Nuclear pore complex protein Nup50 Proteins 0.000 description 1
- 101000721835 Homo sapiens Nuclear pore complex protein Nup98-Nup96 Proteins 0.000 description 1
- 101001109685 Homo sapiens Nuclear receptor subfamily 5 group A member 2 Proteins 0.000 description 1
- 101000991410 Homo sapiens Nucleolar and spindle-associated protein 1 Proteins 0.000 description 1
- 101001024723 Homo sapiens Nucleoporin NDC1 Proteins 0.000 description 1
- 101001074395 Homo sapiens PRELI domain containing protein 3B Proteins 0.000 description 1
- 101000915565 Homo sapiens Palmitoyltransferase ZDHHC3 Proteins 0.000 description 1
- 101001060736 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP1B Proteins 0.000 description 1
- 101001031398 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP9 Proteins 0.000 description 1
- 101001091194 Homo sapiens Peptidyl-prolyl cis-trans isomerase G Proteins 0.000 description 1
- 101001124867 Homo sapiens Peroxiredoxin-1 Proteins 0.000 description 1
- 101000595746 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Proteins 0.000 description 1
- 101000595918 Homo sapiens Phospholipase A and acyltransferase 4 Proteins 0.000 description 1
- 101001133656 Homo sapiens Plasminogen activator inhibitor 1 RNA-binding protein Proteins 0.000 description 1
- 101000610107 Homo sapiens Pre-B-cell leukemia transcription factor 1 Proteins 0.000 description 1
- 101000864677 Homo sapiens Probable ATP-dependent RNA helicase DHX40 Proteins 0.000 description 1
- 101000983583 Homo sapiens Procathepsin L Proteins 0.000 description 1
- 101000705756 Homo sapiens Proteasome activator complex subunit 1 Proteins 0.000 description 1
- 101001136888 Homo sapiens Proteasome subunit alpha type-3 Proteins 0.000 description 1
- 101001124667 Homo sapiens Proteasome subunit alpha type-5 Proteins 0.000 description 1
- 101001090813 Homo sapiens Proteasome subunit alpha type-6 Proteins 0.000 description 1
- 101001136981 Homo sapiens Proteasome subunit beta type-9 Proteins 0.000 description 1
- 101000761460 Homo sapiens Protein CASP Proteins 0.000 description 1
- 101000817237 Homo sapiens Protein ECT2 Proteins 0.000 description 1
- 101000583797 Homo sapiens Protein MCM10 homolog Proteins 0.000 description 1
- 101000990964 Homo sapiens Protein MIS12 homolog Proteins 0.000 description 1
- 101000979599 Homo sapiens Protein NKG7 Proteins 0.000 description 1
- 101001133654 Homo sapiens Protein PALS1 Proteins 0.000 description 1
- 101001074602 Homo sapiens Protein PIMREG Proteins 0.000 description 1
- 101000620365 Homo sapiens Protein TMEPAI Proteins 0.000 description 1
- 101000742054 Homo sapiens Protein phosphatase 1D Proteins 0.000 description 1
- 101000601993 Homo sapiens Protocadherin gamma-C3 Proteins 0.000 description 1
- 101000579957 Homo sapiens RANBP2-like and GRIP domain-containing protein 8 Proteins 0.000 description 1
- 101000668168 Homo sapiens RNA-binding motif, single-stranded-interacting protein 3 Proteins 0.000 description 1
- 101000620856 Homo sapiens Rab5 GDP/GTP exchange factor Proteins 0.000 description 1
- 101000926086 Homo sapiens Rap1 GTPase-GDP dissociation stimulator 1 Proteins 0.000 description 1
- 101001110313 Homo sapiens Ras-related C3 botulinum toxin substrate 2 Proteins 0.000 description 1
- 101001130437 Homo sapiens Ras-related protein Rap-2b Proteins 0.000 description 1
- 101000650344 Homo sapiens RecQ-mediated genome instability protein 1 Proteins 0.000 description 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 1
- 101000849747 Homo sapiens Regulation of nuclear pre-mRNA domain-containing protein 1A Proteins 0.000 description 1
- 101000630197 Homo sapiens Rho GTPase-activating protein SYDE1 Proteins 0.000 description 1
- 101000575639 Homo sapiens Ribonucleoside-diphosphate reductase subunit M2 Proteins 0.000 description 1
- 101000873502 Homo sapiens S-adenosylmethionine decarboxylase proenzyme Proteins 0.000 description 1
- 101000633782 Homo sapiens SLAM family member 8 Proteins 0.000 description 1
- 101000835998 Homo sapiens SRA stem-loop-interacting RNA-binding protein, mitochondrial Proteins 0.000 description 1
- 101000879761 Homo sapiens Sarcospan Proteins 0.000 description 1
- 101000851593 Homo sapiens Separin Proteins 0.000 description 1
- 101000700735 Homo sapiens Serine/arginine-rich splicing factor 7 Proteins 0.000 description 1
- 101000649929 Homo sapiens Serine/threonine-protein kinase VRK1 Proteins 0.000 description 1
- 101000929936 Homo sapiens Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Proteins 0.000 description 1
- 101000828971 Homo sapiens Signal peptidase complex subunit 3 Proteins 0.000 description 1
- 101000713305 Homo sapiens Sodium-coupled neutral amino acid transporter 1 Proteins 0.000 description 1
- 101000618133 Homo sapiens Sperm-associated antigen 5 Proteins 0.000 description 1
- 101000703512 Homo sapiens Sphingosine-1-phosphate phosphatase 1 Proteins 0.000 description 1
- 101000658071 Homo sapiens Splicing factor U2AF 65 kDa subunit Proteins 0.000 description 1
- 101000825933 Homo sapiens Structural maintenance of chromosomes flexible hinge domain-containing protein 1 Proteins 0.000 description 1
- 101000659054 Homo sapiens Synaptopodin Proteins 0.000 description 1
- 101000634836 Homo sapiens T cell receptor alpha chain MC.7.G5 Proteins 0.000 description 1
- 101000763321 Homo sapiens T cell receptor beta chain MC.7.G5 Proteins 0.000 description 1
- 101000634866 Homo sapiens TRAF-type zinc finger domain-containing protein 1 Proteins 0.000 description 1
- 101000800055 Homo sapiens Testican-1 Proteins 0.000 description 1
- 101000680015 Homo sapiens Thioredoxin-related transmembrane protein 1 Proteins 0.000 description 1
- 101000796134 Homo sapiens Thymidine phosphorylase Proteins 0.000 description 1
- 101000596771 Homo sapiens Transcription factor 7-like 2 Proteins 0.000 description 1
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 description 1
- 101000679343 Homo sapiens Transformer-2 protein homolog beta Proteins 0.000 description 1
- 101000836150 Homo sapiens Transforming acidic coiled-coil-containing protein 3 Proteins 0.000 description 1
- 101000635958 Homo sapiens Transforming growth factor beta-2 proprotein Proteins 0.000 description 1
- 101000638204 Homo sapiens Transmembrane emp24 domain-containing protein 5 Proteins 0.000 description 1
- 101000763433 Homo sapiens Transmembrane protein 204 Proteins 0.000 description 1
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 description 1
- 101000641003 Homo sapiens Tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 description 1
- 101001094573 Homo sapiens U1 small nuclear ribonucleoprotein C Proteins 0.000 description 1
- 101000841477 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 14 Proteins 0.000 description 1
- 101000939255 Homo sapiens Ubiquitin-associated protein 1 Proteins 0.000 description 1
- 101000644689 Homo sapiens Ubiquitin-conjugating enzyme E2 K Proteins 0.000 description 1
- 101000761740 Homo sapiens Ubiquitin/ISG15-conjugating enzyme E2 L6 Proteins 0.000 description 1
- 101000671638 Homo sapiens Vesicle transport protein USE1 Proteins 0.000 description 1
- 101000639146 Homo sapiens Vesicle-associated membrane protein 4 Proteins 0.000 description 1
- 101000775932 Homo sapiens Vesicle-associated membrane protein-associated protein B/C Proteins 0.000 description 1
- 101000983936 Homo sapiens Voltage-dependent L-type calcium channel subunit beta-3 Proteins 0.000 description 1
- 101000955064 Homo sapiens WAP four-disulfide core domain protein 1 Proteins 0.000 description 1
- 101000771675 Homo sapiens WD repeat and HMG-box DNA-binding protein 1 Proteins 0.000 description 1
- 101000823778 Homo sapiens Y-box-binding protein 2 Proteins 0.000 description 1
- 101000744718 Homo sapiens YTH domain-containing family protein 3 Proteins 0.000 description 1
- 101000916514 Homo sapiens Zinc finger CCCH-type antiviral protein 1 Proteins 0.000 description 1
- 101000759255 Homo sapiens Zinc finger protein 148 Proteins 0.000 description 1
- 101000723909 Homo sapiens Zinc finger protein 304 Proteins 0.000 description 1
- 101000760246 Homo sapiens Zinc finger protein 345 Proteins 0.000 description 1
- 101000964559 Homo sapiens Zymogen granule membrane protein 16 Proteins 0.000 description 1
- 101001022836 Homo sapiens c-Myc-binding protein Proteins 0.000 description 1
- 101001039684 Homo sapiens mRNA cap guanine-N7 methyltransferase Proteins 0.000 description 1
- 101000963221 Homo sapiens mRNA guanylyltransferase Proteins 0.000 description 1
- 101000828889 Homo sapiens tRNA modification GTPase GTPBP3, mitochondrial Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 241000701806 Human papillomavirus Species 0.000 description 1
- 102100030358 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Human genes 0.000 description 1
- 101150050155 ILK gene Proteins 0.000 description 1
- 108010042653 IgA receptor Proteins 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 208000025814 Inflammatory myopathy with abundant macrophages Diseases 0.000 description 1
- 101710124906 Inorganic pyrophosphatase 2, mitochondrial Proteins 0.000 description 1
- 229930010555 Inosine Natural products 0.000 description 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
- 108010041012 Integrin alpha4 Proteins 0.000 description 1
- 102100020944 Integrin-linked protein kinase Human genes 0.000 description 1
- 108090000890 Interferon regulatory factor 1 Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102100024064 Interferon-inducible protein AIM2 Human genes 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 108091092195 Intron Proteins 0.000 description 1
- 102000004195 Isomerases Human genes 0.000 description 1
- 108090000769 Isomerases Proteins 0.000 description 1
- 108010062228 Karyopherins Proteins 0.000 description 1
- 102000011781 Karyopherins Human genes 0.000 description 1
- 102000010638 Kinesin Human genes 0.000 description 1
- 108010063296 Kinesin Proteins 0.000 description 1
- 102100027629 Kinesin-like protein KIF11 Human genes 0.000 description 1
- 102100027630 Kinesin-like protein KIF15 Human genes 0.000 description 1
- 102100034895 Kinesin-like protein KIF18A Human genes 0.000 description 1
- 102100038406 Kinesin-like protein KIF23 Human genes 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 101710205833 La protein homolog Proteins 0.000 description 1
- 102100020861 La-related protein 4 Human genes 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 1
- 108010015340 Low Density Lipoprotein Receptor-Related Protein-1 Proteins 0.000 description 1
- 102100040705 Low-density lipoprotein receptor-related protein 8 Human genes 0.000 description 1
- 102100022742 Lupus La protein Human genes 0.000 description 1
- 101710088635 Lupus La protein homolog Proteins 0.000 description 1
- 102100040788 Lutropin-choriogonadotropic hormone receptor Human genes 0.000 description 1
- 102100034709 Lymphocyte cytosolic protein 2 Human genes 0.000 description 1
- 102100024625 Lysosomal-associated transmembrane protein 5 Human genes 0.000 description 1
- 102100021437 MOB kinase activator 1A Human genes 0.000 description 1
- 101150079116 MT-CO1 gene Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 108700018351 Major Histocompatibility Complex Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 101710159527 Maturation protein A Proteins 0.000 description 1
- 101710091157 Maturation protein A2 Proteins 0.000 description 1
- 102100037106 Merlin Human genes 0.000 description 1
- 108010010685 Methenyltetrahydrofolate cyclohydrolase Proteins 0.000 description 1
- 102100027320 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Human genes 0.000 description 1
- 102100030144 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Human genes 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 108010028277 Myosin Type I Proteins 0.000 description 1
- 101710202061 N-acetyltransferase Proteins 0.000 description 1
- 101710108550 NAD-dependent malic enzyme, mitochondrial Proteins 0.000 description 1
- 108010086428 NADH Dehydrogenase Proteins 0.000 description 1
- 102000006746 NADH Dehydrogenase Human genes 0.000 description 1
- 108020001028 NR5 subfamily Proteins 0.000 description 1
- 102100036942 Nck-associated protein 1-like Human genes 0.000 description 1
- 101710199621 Nck-associated protein 1-like Proteins 0.000 description 1
- 101100445008 Nematostella vectensis etnk gene Proteins 0.000 description 1
- 108010085839 Neurofibromin 2 Proteins 0.000 description 1
- 102000007517 Neurofibromin 2 Human genes 0.000 description 1
- 101710138657 Neurotoxin Proteins 0.000 description 1
- 102100031346 Non-histone chromosomal protein HMG-17 Human genes 0.000 description 1
- 102100037669 Non-receptor tyrosine-protein kinase TNK1 Human genes 0.000 description 1
- 102000007999 Nuclear Proteins Human genes 0.000 description 1
- 108010089610 Nuclear Proteins Proteins 0.000 description 1
- 102100025447 Nuclear pore complex protein Nup50 Human genes 0.000 description 1
- 102100022669 Nuclear receptor subfamily 5 group A member 2 Human genes 0.000 description 1
- 102100030991 Nucleolar and spindle-associated protein 1 Human genes 0.000 description 1
- 101710093525 Nucleoporin NDC1 Proteins 0.000 description 1
- 108010026867 Oligo-1,6-Glucosidase Proteins 0.000 description 1
- 102000002131 PAS domains Human genes 0.000 description 1
- 108050009469 PAS domains Proteins 0.000 description 1
- 238000009004 PCR Kit Methods 0.000 description 1
- 238000010222 PCR analysis Methods 0.000 description 1
- 239000012807 PCR reagent Substances 0.000 description 1
- 108010014971 PDZ-binding kinase Proteins 0.000 description 1
- 108091007960 PI3Ks Proteins 0.000 description 1
- 102100036156 PRELI domain containing protein 3B Human genes 0.000 description 1
- 102100028620 Palmitoyltransferase ZDHHC3 Human genes 0.000 description 1
- 101000669384 Papaver somniferum Reticuline N-methyltransferase Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 101710147136 Peptidyl-prolyl cis-trans isomerase FKBP9 Proteins 0.000 description 1
- 101710111200 Peptidyl-prolyl cis-trans isomerase G Proteins 0.000 description 1
- 108010056995 Perforin Proteins 0.000 description 1
- KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 description 1
- 102000007456 Peroxiredoxin Human genes 0.000 description 1
- 108010012822 Peroxiredoxin III Proteins 0.000 description 1
- 102100029139 Peroxiredoxin-1 Human genes 0.000 description 1
- 206010034764 Peutz-Jeghers syndrome Diseases 0.000 description 1
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 description 1
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 description 1
- 102100036056 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Human genes 0.000 description 1
- 102100035200 Phospholipase A and acyltransferase 4 Human genes 0.000 description 1
- 102000015082 Phosphoribosylglycinamide formyltransferase Human genes 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 1
- 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 description 1
- 102100034055 Plasminogen activator inhibitor 1 RNA-binding protein Human genes 0.000 description 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
- 102100037596 Platelet-derived growth factor subunit A Human genes 0.000 description 1
- 102100040171 Pre-B-cell leukemia transcription factor 1 Human genes 0.000 description 1
- 102100030094 Probable ATP-dependent RNA helicase DHX40 Human genes 0.000 description 1
- 101710146427 Probable tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 description 1
- 102100026534 Procathepsin L Human genes 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 102100021923 Prolow-density lipoprotein receptor-related protein 1 Human genes 0.000 description 1
- 102100034014 Prolyl 3-hydroxylase 3 Human genes 0.000 description 1
- 101710125002 Prostaglandin E2 receptor EP3 subtype Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100031300 Proteasome activator complex subunit 1 Human genes 0.000 description 1
- 102100035908 Proteasome subunit alpha type-3 Human genes 0.000 description 1
- 102100029270 Proteasome subunit alpha type-5 Human genes 0.000 description 1
- 102100034664 Proteasome subunit alpha type-6 Human genes 0.000 description 1
- 102100035764 Proteasome subunit beta type-9 Human genes 0.000 description 1
- 101800004937 Protein C Proteins 0.000 description 1
- 102100040437 Protein ECT2 Human genes 0.000 description 1
- 102100030962 Protein MCM10 homolog Human genes 0.000 description 1
- 102100030327 Protein MIS12 homolog Human genes 0.000 description 1
- 102100023370 Protein NKG7 Human genes 0.000 description 1
- 102100034054 Protein PALS1 Human genes 0.000 description 1
- 102100036258 Protein PIMREG Human genes 0.000 description 1
- 102100022429 Protein TMEPAI Human genes 0.000 description 1
- 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 description 1
- 102100037277 Protein fem-1 homolog C Human genes 0.000 description 1
- 101710105658 Protein phosphatase 1D Proteins 0.000 description 1
- 108700020978 Proto-Oncogene Proteins 0.000 description 1
- 102000052575 Proto-Oncogene Human genes 0.000 description 1
- 102100037560 Protocadherin gamma-C3 Human genes 0.000 description 1
- 206010056626 Pseudopolyp Diseases 0.000 description 1
- 102100036286 Purine nucleoside phosphorylase Human genes 0.000 description 1
- 102100039156 Queuine tRNA-ribosyltransferase catalytic subunit 1 Human genes 0.000 description 1
- 108010005730 R-SNARE Proteins Proteins 0.000 description 1
- 102000005917 R-SNARE Proteins Human genes 0.000 description 1
- 101710172027 RANBP2-like and GRIP domain-containing protein 8 Proteins 0.000 description 1
- 230000004570 RNA-binding Effects 0.000 description 1
- 101710089258 RNA-binding motif protein 25 Proteins 0.000 description 1
- 102100039689 RNA-binding motif, single-stranded-interacting protein 3 Human genes 0.000 description 1
- 101710205948 RNA-binding protein 25 Proteins 0.000 description 1
- 238000011530 RNeasy Mini Kit Methods 0.000 description 1
- 102000002024 Rabaptin Human genes 0.000 description 1
- 108050009305 Rabaptin Proteins 0.000 description 1
- 102100034329 Rap1 GTPase-GDP dissociation stimulator 1 Human genes 0.000 description 1
- 102000003901 Ras GTPase-activating proteins Human genes 0.000 description 1
- 108090000231 Ras GTPase-activating proteins Proteins 0.000 description 1
- 102100022129 Ras-related C3 botulinum toxin substrate 2 Human genes 0.000 description 1
- 102100031421 Ras-related protein Rap-2b Human genes 0.000 description 1
- 102100027431 RecQ-mediated genome instability protein 1 Human genes 0.000 description 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 1
- 102100033797 Regulation of nuclear pre-mRNA domain-containing protein 1A Human genes 0.000 description 1
- 102100026203 Rho GTPase-activating protein SYDE1 Human genes 0.000 description 1
- 108091078243 Rho family Proteins 0.000 description 1
- 102000042463 Rho family Human genes 0.000 description 1
- 102100026006 Ribonucleoside-diphosphate reductase subunit M2 Human genes 0.000 description 1
- 108091028664 Ribonucleotide Proteins 0.000 description 1
- 108010041388 Ribonucleotide Reductases Proteins 0.000 description 1
- 102000000505 Ribonucleotide Reductases Human genes 0.000 description 1
- 108090000904 Ribosomal protein S2 Proteins 0.000 description 1
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 description 1
- 102100035914 S-adenosylmethionine decarboxylase proenzyme Human genes 0.000 description 1
- 102000014400 SH2 domains Human genes 0.000 description 1
- 108050003452 SH2 domains Proteins 0.000 description 1
- 102100024865 SH3 domain-binding protein 2 Human genes 0.000 description 1
- 101710161468 SH3 domain-binding protein 2 Proteins 0.000 description 1
- 102000000395 SH3 domains Human genes 0.000 description 1
- 108050008861 SH3 domains Proteins 0.000 description 1
- 101710083288 SLAM family member 8 Proteins 0.000 description 1
- 102000008935 SMN Complex Proteins Human genes 0.000 description 1
- 108010049037 SMN Complex Proteins Proteins 0.000 description 1
- 108700022176 SOS1 Proteins 0.000 description 1
- 102100025491 SRA stem-loop-interacting RNA-binding protein, mitochondrial Human genes 0.000 description 1
- 101100501251 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ELO3 gene Proteins 0.000 description 1
- 101001050208 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Putative ATP-dependent RNA helicase ECM32 Proteins 0.000 description 1
- 101100197320 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) RPL35A gene Proteins 0.000 description 1
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 description 1
- 101800001700 Saposin-D Proteins 0.000 description 1
- 108010083379 Sarcoglycans Proteins 0.000 description 1
- 102000006308 Sarcoglycans Human genes 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 102000011265 Sarcospan Human genes 0.000 description 1
- 102100037329 Sarcospan Human genes 0.000 description 1
- 108050001531 Sarcospan Proteins 0.000 description 1
- 101100010298 Schizosaccharomyces pombe (strain 972 / ATCC 24843) pol2 gene Proteins 0.000 description 1
- 102100036750 Separin Human genes 0.000 description 1
- 102100029287 Serine/arginine-rich splicing factor 7 Human genes 0.000 description 1
- 101710177328 Serine/threonine-protein kinase Chk1 Proteins 0.000 description 1
- 101710183229 Serine/threonine-protein kinase PLK4 Proteins 0.000 description 1
- 102100028235 Serine/threonine-protein kinase VRK1 Human genes 0.000 description 1
- 101710098564 Serine/threonine-protein kinase tousled-like 1 Proteins 0.000 description 1
- 102000009105 Short Chain Dehydrogenase-Reductases Human genes 0.000 description 1
- 108010048287 Short Chain Dehydrogenase-Reductases Proteins 0.000 description 1
- 102100035766 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 description 1
- 102100023789 Signal peptidase complex subunit 3 Human genes 0.000 description 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
- 101150045565 Socs1 gene Proteins 0.000 description 1
- 101710146001 Son of sevenless homolog 1 Proteins 0.000 description 1
- 101150100839 Sos1 gene Proteins 0.000 description 1
- 101710163792 Sp110 nuclear body protein Proteins 0.000 description 1
- 108010023876 Sp3 Transcription Factor Proteins 0.000 description 1
- 108010019965 Spectrin Proteins 0.000 description 1
- 102000005890 Spectrin Human genes 0.000 description 1
- 101710098571 Sperm-associated antigen 5 Proteins 0.000 description 1
- 102100030684 Sphingosine-1-phosphate phosphatase 1 Human genes 0.000 description 1
- 102100035040 Splicing factor U2AF 65 kDa subunit Human genes 0.000 description 1
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 description 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 description 1
- 101000697584 Streptomyces lavendulae Streptothricin acetyltransferase Proteins 0.000 description 1
- 102100022770 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 Human genes 0.000 description 1
- 102100027918 Sucrase-isomaltase, intestinal Human genes 0.000 description 1
- 108700027336 Suppressor of Cytokine Signaling 1 Proteins 0.000 description 1
- 102100024779 Suppressor of cytokine signaling 1 Human genes 0.000 description 1
- 101710119889 Synaptopodin Proteins 0.000 description 1
- 102100029454 T cell receptor alpha chain MC.7.G5 Human genes 0.000 description 1
- 102100026967 T cell receptor beta chain MC.7.G5 Human genes 0.000 description 1
- 108010029625 T-Box Domain Protein 2 Proteins 0.000 description 1
- 101710167702 T-box transcription factor TBX2 Proteins 0.000 description 1
- 102100029451 TRAF-type zinc finger domain-containing protein 1 Human genes 0.000 description 1
- 102100040128 TRAF3-interacting JNK-activating modulator Human genes 0.000 description 1
- 101710099675 TRAF3-interacting JNK-activating modulator Proteins 0.000 description 1
- 101800000849 Tachykinin-associated peptide 2 Proteins 0.000 description 1
- 102100033390 Testican-1 Human genes 0.000 description 1
- 102000011362 Thioredoxin domains Human genes 0.000 description 1
- 108050001669 Thioredoxin domains Proteins 0.000 description 1
- 102100022169 Thioredoxin-related transmembrane protein 1 Human genes 0.000 description 1
- 108010022394 Threonine synthase Proteins 0.000 description 1
- 102100031372 Thymidine phosphorylase Human genes 0.000 description 1
- 102000005497 Thymidylate Synthase Human genes 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 101710183280 Topoisomerase Proteins 0.000 description 1
- 101710158136 Trans-prenyltransferase Proteins 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 108700011001 Transcription Factor 7-Like 2 Proteins 0.000 description 1
- 102100022425 Transcription factor Sp3 Human genes 0.000 description 1
- 108010033576 Transferrin Receptors Proteins 0.000 description 1
- 102100022572 Transformer-2 protein homolog beta Human genes 0.000 description 1
- 108010009583 Transforming Growth Factors Proteins 0.000 description 1
- 102000009618 Transforming Growth Factors Human genes 0.000 description 1
- 102100027048 Transforming acidic coiled-coil-containing protein 3 Human genes 0.000 description 1
- 102100030737 Transforming growth factor beta-2 proprotein Human genes 0.000 description 1
- 102100032105 Transmembrane emp24 domain-containing protein 5 Human genes 0.000 description 1
- 102100027027 Transmembrane protein 204 Human genes 0.000 description 1
- 108010020713 Tth polymerase Proteins 0.000 description 1
- 108010046308 Type II DNA Topoisomerases Proteins 0.000 description 1
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 description 1
- 102100034298 Tyrosine-tRNA ligase, cytoplasmic Human genes 0.000 description 1
- 102100025336 Tyrosine-tRNA ligase, mitochondrial Human genes 0.000 description 1
- 101710107268 Tyrosine-tRNA ligase, mitochondrial Proteins 0.000 description 1
- 102100035136 U1 small nuclear ribonucleoprotein C Human genes 0.000 description 1
- 108090000848 Ubiquitin Proteins 0.000 description 1
- 102000044159 Ubiquitin Human genes 0.000 description 1
- 101710138219 Ubiquitin D Proteins 0.000 description 1
- 102100029163 Ubiquitin carboxyl-terminal hydrolase 14 Human genes 0.000 description 1
- 102000003431 Ubiquitin-Conjugating Enzyme Human genes 0.000 description 1
- 108060008747 Ubiquitin-Conjugating Enzyme Proteins 0.000 description 1
- 108010066496 Ubiquitin-Specific Proteases Proteins 0.000 description 1
- 102000018390 Ubiquitin-Specific Proteases Human genes 0.000 description 1
- 101710101253 Ubiquitin-associated protein 1 Proteins 0.000 description 1
- 102100020696 Ubiquitin-conjugating enzyme E2 K Human genes 0.000 description 1
- 102100024843 Ubiquitin/ISG15-conjugating enzyme E2 L6 Human genes 0.000 description 1
- 102100026776 Unconventional myosin-Ib Human genes 0.000 description 1
- 101100472987 Ustilago sphaerogena RNU2 gene Proteins 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- 102100040106 Vesicle transport protein USE1 Human genes 0.000 description 1
- 102100031489 Vesicle-associated membrane protein 4 Human genes 0.000 description 1
- 102100032026 Vesicle-associated membrane protein-associated protein B/C Human genes 0.000 description 1
- 208000014070 Vestibular schwannoma Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 102100025838 Voltage-dependent L-type calcium channel subunit beta-3 Human genes 0.000 description 1
- 102100038968 WAP four-disulfide core domain protein 1 Human genes 0.000 description 1
- 102100029469 WD repeat and HMG-box DNA-binding protein 1 Human genes 0.000 description 1
- 238000001793 Wilcoxon signed-rank test Methods 0.000 description 1
- 208000006254 Wolf-Hirschhorn Syndrome Diseases 0.000 description 1
- 241000269368 Xenopus laevis Species 0.000 description 1
- 101710100133 Y-box-binding protein 2 Proteins 0.000 description 1
- 102100039674 YTH domain-containing family protein 3 Human genes 0.000 description 1
- 102100039102 ZW10 interactor Human genes 0.000 description 1
- 101710177447 ZW10 interactor Proteins 0.000 description 1
- 102100028882 Zinc finger CCCH-type antiviral protein 1 Human genes 0.000 description 1
- 101710145443 Zinc finger protein 148 Proteins 0.000 description 1
- 101710146816 Zinc finger protein 304 Proteins 0.000 description 1
- 101710146967 Zinc finger protein 345 Proteins 0.000 description 1
- OGQICQVSFDPSEI-UHFFFAOYSA-N Zorac Chemical compound N1=CC(C(=O)OCC)=CC=C1C#CC1=CC=C(SCCC2(C)C)C2=C1 OGQICQVSFDPSEI-UHFFFAOYSA-N 0.000 description 1
- 101710186263 Zymogen granule membrane protein 16 Proteins 0.000 description 1
- IJVSLWIGTVPSKZ-HJZCUYRDSA-N [(2-amino-2-oxoethyl)-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]amino]phosphonic acid Chemical compound NC(=O)CN(P(O)(O)=O)C1O[C@H](CO)[C@@H](O)[C@H]1O IJVSLWIGTVPSKZ-HJZCUYRDSA-N 0.000 description 1
- ZPCCSZFPOXBNDL-ZSTSFXQOSA-N [(4r,5s,6s,7r,9r,10r,11e,13e,16r)-6-[(2s,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2r,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoe Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]([C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)OC(C)=O)[C@H]1CC[C@H](N(C)C)[C@@H](C)O1 ZPCCSZFPOXBNDL-ZSTSFXQOSA-N 0.000 description 1
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 208000004064 acoustic neuroma Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- YDGMGEXADBMOMJ-UHFFFAOYSA-N asymmetrical dimethylarginine Natural products CN(C)C(N)=NCCCC(N)C(O)=O YDGMGEXADBMOMJ-UHFFFAOYSA-N 0.000 description 1
- 239000005441 aurora Substances 0.000 description 1
- 238000003705 background correction Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 238000003766 bioinformatics method Methods 0.000 description 1
- 230000007321 biological mechanism Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 101710193923 c-Myc-binding protein Proteins 0.000 description 1
- AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 108010051348 cdc42 GTP-Binding Protein Proteins 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000029664 classic familial adenomatous polyposis Diseases 0.000 description 1
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 201000010989 colorectal carcinoma Diseases 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000010219 correlation analysis Methods 0.000 description 1
- 208000017563 cutaneous Paget disease Diseases 0.000 description 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000000432 density-gradient centrifugation Methods 0.000 description 1
- 239000005547 deoxyribonucleotide Substances 0.000 description 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- NRUQNUIWEUZVLI-UHFFFAOYSA-O diethanolammonium nitrate Chemical compound [O-][N+]([O-])=O.OCC[NH2+]CCO NRUQNUIWEUZVLI-UHFFFAOYSA-O 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 150000008195 galaktosides Chemical class 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 108010024999 gephyrin Proteins 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 102000009543 guanyl-nucleotide exchange factor activity proteins Human genes 0.000 description 1
- 108040001860 guanyl-nucleotide exchange factor activity proteins Proteins 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 235000019514 herring Nutrition 0.000 description 1
- 108010030457 histone acetyltransferase type B complex Proteins 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000005745 host immune response Effects 0.000 description 1
- 208000017819 hyperplastic polyp Diseases 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 238000012308 immunohistochemistry method Methods 0.000 description 1
- 238000010324 immunological assay Methods 0.000 description 1
- 201000004933 in situ carcinoma Diseases 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000030214 innervation Effects 0.000 description 1
- 229960003786 inosine Drugs 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 108010051621 interferon regulatory factor-8 Proteins 0.000 description 1
- 108010028930 invariant chain Proteins 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 208000020123 juvenile polyp Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 201000010260 leiomyoma Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004901 leucine-rich repeat Anatomy 0.000 description 1
- 208000002741 leukoplakia Diseases 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 238000007477 logistic regression Methods 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000001581 lymphogranuloma venereum Diseases 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 102100040949 mRNA cap guanine-N7 methyltransferase Human genes 0.000 description 1
- 102100039604 mRNA guanylyltransferase Human genes 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 208000004141 microcephaly Diseases 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000002581 neurotoxin Substances 0.000 description 1
- 231100000618 neurotoxin Toxicity 0.000 description 1
- 108010054452 nuclear pore complex protein 98 Proteins 0.000 description 1
- 108010009099 nucleoside phosphorylase Proteins 0.000 description 1
- 238000002515 oligonucleotide synthesis Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 108010023005 oxoglutarate translocator Proteins 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 229930192851 perforin Natural products 0.000 description 1
- 108030002458 peroxiredoxin Proteins 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 102000030592 phosphoserine aminotransferase Human genes 0.000 description 1
- 108010088694 phosphoserine aminotransferase Proteins 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 108010017843 platelet-derived growth factor A Proteins 0.000 description 1
- 229920003195 poly(n-butyl isocyanate) Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000513 principal component analysis Methods 0.000 description 1
- 230000001915 proofreading effect Effects 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 108020000494 protein-tyrosine phosphatase Proteins 0.000 description 1
- 238000000575 proteomic method Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 108010061997 queuine tRNA-ribosyltransferase Proteins 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 108090000064 retinoic acid receptors Proteins 0.000 description 1
- 102000003702 retinoic acid receptors Human genes 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 108010047866 ribonucleotide reductase M2 Proteins 0.000 description 1
- 108010025387 ribosomal protein L39 Proteins 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 101150024074 rub1 gene Proteins 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000010187 selection method Methods 0.000 description 1
- 238000003196 serial analysis of gene expression Methods 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- PVGBHEUCHKGFQP-UHFFFAOYSA-N sodium;n-[5-amino-2-(4-aminophenyl)sulfonylphenyl]sulfonylacetamide Chemical compound [Na+].CC(=O)NS(=O)(=O)C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 PVGBHEUCHKGFQP-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 102100023793 tRNA modification GTPase GTPBP3, mitochondrial Human genes 0.000 description 1
- 101710116778 tRNA modification GTPase gtpbp3, mitochondrial Proteins 0.000 description 1
- 229960000565 tazarotene Drugs 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 102000004217 thyroid hormone receptors Human genes 0.000 description 1
- 108090000721 thyroid hormone receptors Proteins 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 208000022271 tubular adenoma Diseases 0.000 description 1
- 208000022158 tubulovillous adenoma Diseases 0.000 description 1
- 239000000439 tumor marker Substances 0.000 description 1
- 108010087967 type I signal peptidase Proteins 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/30—Microarray design
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ544432 | 2005-12-23 | ||
| NZ544432A NZ544432A (en) | 2005-12-23 | 2005-12-23 | Prognosis prediction for colorectal cancer using a prognositc signature comprising markers ME2 and FAS |
| CA2640352A CA2640352C (en) | 2005-12-23 | 2006-12-22 | Prognosis prediction for colorectal cancer |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2640352A Division CA2640352C (en) | 2005-12-23 | 2006-12-22 | Prognosis prediction for colorectal cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3015335A1 true CA3015335A1 (en) | 2007-06-28 |
Family
ID=38188869
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3015335A Abandoned CA3015335A1 (en) | 2005-12-23 | 2006-12-22 | Prognosis prediction for colorectal cancer |
| CA2640352A Expired - Fee Related CA2640352C (en) | 2005-12-23 | 2006-12-22 | Prognosis prediction for colorectal cancer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2640352A Expired - Fee Related CA2640352C (en) | 2005-12-23 | 2006-12-22 | Prognosis prediction for colorectal cancer |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10422005B2 (enExample) |
| EP (3) | EP2371972B1 (enExample) |
| JP (3) | JP5632581B2 (enExample) |
| KR (3) | KR101530689B1 (enExample) |
| CN (1) | CN101389957B (enExample) |
| AU (1) | AU2006328023B2 (enExample) |
| CA (2) | CA3015335A1 (enExample) |
| ES (3) | ES2525219T3 (enExample) |
| NZ (3) | NZ544432A (enExample) |
| WO (1) | WO2007073220A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2783348B1 (fr) * | 1998-09-15 | 2000-10-13 | Alstom Technology | Methode de discrimination entre un arc interne et un arc de coupure dans un disjoncteur de moyenne ou de haute tension |
| EP2947160B1 (en) | 2004-04-09 | 2017-07-12 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
| NZ593226A (en) | 2006-01-11 | 2012-10-26 | Genomic Health Inc | Gene expression markers (efnb2) for colorectal cancer prognosis |
| ES2599816T3 (es) * | 2006-07-21 | 2017-02-03 | Epigenomics Ag | Métodos relacionados con el gen GLI3 para la detección de cáncer colorrectal |
| DE102006035393A1 (de) * | 2006-11-02 | 2008-05-15 | Signature Diagnostics Ag | Prognostische Marker für die Klassifizierung des dreijährigen progessionsfreien Überlebens von Patienten mit Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben |
| US20090076734A1 (en) | 2007-03-22 | 2009-03-19 | Torres-Roca Javier F | Gene Signature for the Prediction of Radiation Therapy Response |
| US20080234946A1 (en) * | 2007-03-22 | 2008-09-25 | University Of South Florida | Predictive radiosensitivity network model |
| EP2544006A1 (en) * | 2007-06-04 | 2013-01-09 | Diagnoplex | Biomarker combinations for colorectal cancer |
| NZ562237A (en) * | 2007-10-05 | 2011-02-25 | Pacific Edge Biotechnology Ltd | Proliferation signature and prognosis for gastrointestinal cancer |
| ES2332557B1 (es) | 2007-12-04 | 2011-02-02 | Universidad Autonoma De Madrid | Huella genomica para el pronostico de la evolucion de adenocarcinoma colorectal. |
| CN104376147B (zh) * | 2009-02-02 | 2018-07-17 | 罗格斯新泽西州立大学 | 基于图像的风险分数的图像分析系统 |
| NZ596054A (en) | 2009-05-01 | 2013-07-26 | Genomic Health Inc | Gene expression profile algorithm and test for likelihood of recurrence of colorectal cancer and response to chemotherapy |
| EP2454596B1 (en) | 2009-07-16 | 2014-06-11 | Roche Diagnostics GmbH | Flap endonuclease-1 as a marker for cancer |
| US8445271B2 (en) | 2010-05-03 | 2013-05-21 | Enzo Life Sciences, Inc. | Processes and kits for determining multi-drug resistance of cells |
| WO2011140662A1 (en) * | 2010-05-13 | 2011-11-17 | The Royal Institution For The Advancement Of Learning / Mcgill University | Cux1 signature for determination of cancer clinical outcome |
| JP5916718B2 (ja) * | 2010-06-04 | 2016-05-11 | ビオメリューBiomerieux | 結腸直腸癌の予後判定のための方法及びキット |
| US9539323B2 (en) | 2010-08-06 | 2017-01-10 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for malic enzyme 2 (ME2) as a target for cancer therapy |
| KR101401561B1 (ko) * | 2010-12-30 | 2014-06-11 | 주식회사 바이오인프라 | 복합 바이오마커를 활용한 암 진단 정보 생성 방법, 및 암 진단 예측 시스템 장치 |
| US20120184454A1 (en) * | 2011-01-14 | 2012-07-19 | Kalady Matthew F | Gene signature is associated with early stage rectal cancer recurrence |
| CN102183662A (zh) * | 2011-03-22 | 2011-09-14 | 浙江大学 | 一种大肠癌预后预测模型的建立方法 |
| CA2857073A1 (en) * | 2011-11-28 | 2013-06-06 | Institucio Catalana De Recerca I Estudis Avancats | Methods and kits for the prognosis of colorectal cancer |
| US9977033B2 (en) * | 2012-09-11 | 2018-05-22 | The Board Of Regents Of The University Of Texas System | Methods for assessing cancer recurrence |
| KR20160045547A (ko) | 2014-10-17 | 2016-04-27 | 에스케이텔레콤 주식회사 | 췌장암 진단용 조성물 및 이를 이용한 췌장암 진단방법 |
| CN105021828B (zh) * | 2015-07-20 | 2017-07-28 | 上海交通大学医学院附属新华医院 | 通过检测三期结直肠肿瘤患者血清预测肿瘤患者预后 |
| SG11201806609TA (en) | 2016-02-02 | 2018-09-27 | Guardant Health Inc | Cancer evolution detection and diagnostic |
| WO2017143322A1 (en) | 2016-02-18 | 2017-08-24 | University Of South Florida | Materials and methods for detecting cancer based on urinary levels of rhamm |
| US20190242875A1 (en) | 2016-05-10 | 2019-08-08 | National University Corporation Tokyo Medical And Dental University | Expression Inhibitor of Inflammation Promoting Factor, Screening Method for Active Ingredient Thereof, Expression Cassette Useful for Said Method, Diagnostic Agent and Diagnosis Method |
| US11164082B2 (en) | 2017-02-28 | 2021-11-02 | Anixa Diagnostics Corporation | Methods for using artificial neural network analysis on flow cytometry data for cancer diagnosis |
| US9934364B1 (en) | 2017-02-28 | 2018-04-03 | Anixa Diagnostics Corporation | Methods for using artificial neural network analysis on flow cytometry data for cancer diagnosis |
| US10360499B2 (en) * | 2017-02-28 | 2019-07-23 | Anixa Diagnostics Corporation | Methods for using artificial neural network analysis on flow cytometry data for cancer diagnosis |
| WO2018231772A1 (en) | 2017-06-13 | 2018-12-20 | Bostongene Corporation | Systems and methods for identifying responders and non-responders to immune checkpoint blockade therapy |
| EP3719124A4 (en) | 2017-11-09 | 2021-09-01 | National University Corporation Tokyo Medical and Dental University | CANCER-PROMOTING EXPRESSION INHIBITOR, SCREENING METHOD FOR ACTIVE SUBSTANCE, USEFUL EXPRESSION CASSETTE IN SUCH METHOD, DIAGNOSIS DRUG AND DIAGNOSIS METHOD |
| WO2019154884A1 (en) * | 2018-02-07 | 2019-08-15 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method for determining cancer invasiveness and patient prognosis |
| WO2019173233A1 (en) * | 2018-03-05 | 2019-09-12 | Anixa Diagnostics Corporation | Methods for using artificial neural network analysis on flow cytometry data for cancer diagnosis |
| TW202018727A (zh) | 2018-11-09 | 2020-05-16 | 財團法人工業技術研究院 | 整體式學習預測方法與系統 |
| CN111321221B (zh) * | 2018-12-14 | 2022-09-23 | 中国医学科学院肿瘤医院 | 用于预测直肠癌局部切除手术后复发风险的组合物、微阵列和计算机系统 |
| CN109599181B (zh) * | 2019-01-09 | 2021-04-16 | 中国医学科学院肿瘤医院 | 一种在治疗前针对t3-larc患者的生存预测系统及预测方法 |
| CA3128973A1 (en) | 2019-03-04 | 2020-09-10 | Bhaskar Bhattacharyya | Data compression and communication using machine learning |
| CN109811057B (zh) * | 2019-03-27 | 2022-02-22 | 中山大学附属第六医院 | 缺氧相关基因在结直肠癌预测系统中的应用 |
| CN109762907B (zh) * | 2019-03-27 | 2022-02-22 | 中山大学附属第六医院 | 缺氧相关基因在预测i/ii期结直肠癌的试剂盒中的应用 |
| US11154240B2 (en) | 2019-04-02 | 2021-10-26 | Kpn Innovations Llc | Methods and systems for utilizing diagnostics for informed vibrant constitutional guidance |
| CN110246591B (zh) * | 2019-07-15 | 2021-11-05 | 中国中医科学院西苑医院 | 一种中医药治疗人群的预后预测系统 |
| CN112342295A (zh) * | 2019-08-06 | 2021-02-09 | 中山大学孙逸仙纪念医院 | 一种检测人结直肠癌的肿瘤标志物及其应用 |
| CN110791565B (zh) * | 2019-09-29 | 2021-09-03 | 浙江大学 | 一种用于ii期结直肠癌复发预测的预后标记基因及随机生存森林模型 |
| WO2021119761A1 (en) | 2019-12-20 | 2021-06-24 | Hudson Institute of Medical Research | Cxcl10 binding proteins and uses thereof |
| US12020417B2 (en) * | 2020-04-24 | 2024-06-25 | Camtek Ltd. | Method and system for classifying defects in wafer using wafer-defect images, based on deep learning |
| US11289206B2 (en) | 2020-06-02 | 2022-03-29 | Kpn Innovations, Llc. | Artificial intelligence methods and systems for constitutional analysis using objective functions |
| US12176108B2 (en) | 2020-06-02 | 2024-12-24 | Kpn Innovations Llc | Artificial intelligence methods and systems for constitutional analysis using objective functions |
| US11211158B1 (en) | 2020-08-31 | 2021-12-28 | Kpn Innovations, Llc. | System and method for representing an arranged list of provider aliment possibilities |
| CN112301131B (zh) * | 2020-11-13 | 2021-10-26 | 中国医学科学院基础医学研究所 | Rnf138作为预测结直肠癌对sc75741治疗敏感性的生物标志物的应用 |
| CN113591919B (zh) * | 2021-06-29 | 2023-07-21 | 复旦大学附属中山医院 | 基于ai对早期肝细胞癌术后复发预后的分析方法及系统 |
| WO2023128419A1 (ko) * | 2021-12-31 | 2023-07-06 | 주식회사 이노제닉스 | 대장암 및 대장 용종 또는 진행 선종의 선별 방법 및 그 응용 |
| IT202200001817A1 (it) | 2022-02-02 | 2023-08-02 | Aizoon S R L | Procedimento per la prognosi di una malattia in seguito ad un trattamento terapeutico, relativo sistema e prodotto informatico |
| CN114652814B (zh) * | 2022-03-11 | 2023-02-03 | 郑州大学第一附属医院 | 一种免疫检查点抑制剂及应用 |
| IT202200005861A1 (it) | 2022-03-24 | 2023-09-24 | Aizoon S R L | Procedimento per stimare una variabile di interesse associata ad una data malattia in funzione di una pluralità di diversi dati omici, relativo dispositivo e prodotto informatico |
| CA3207405A1 (en) | 2022-07-25 | 2024-01-25 | Aizoon S.r.l. | Method for providing a clinical decision support, corresponding system for providing a clinical decision support, and computer program product |
| WO2024138106A1 (en) * | 2022-12-23 | 2024-06-27 | The Wistar Institute Of Anatomy And Biology | Compositions and methods for identification of hypomorphic p53 variants |
| CN115938590B (zh) * | 2023-02-09 | 2023-05-02 | 四川大学华西医院 | 结直肠癌术后lars预测模型的构建方法及预测系统 |
| CN117947166B (zh) * | 2024-01-30 | 2025-08-29 | 复旦大学附属肿瘤医院 | 用于肠癌预后的标志物组、产品、系统及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582908B2 (en) * | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| GB9805918D0 (en) * | 1998-03-19 | 1998-05-13 | Nycomed Amersham Plc | Sequencing by hybridisation |
| JP2004510951A (ja) * | 1999-03-15 | 2004-04-08 | イオス バイオテクノロジー,インコーポレイティド | 結腸直腸癌を診断する新規の方法、組成物、結腸直腸癌調節のためのスクリーニング法 |
| WO2002006867A2 (en) | 2000-07-18 | 2002-01-24 | Kvh Industries, Inc. | Method of incorporating optical material into an optical fiber |
| US20030077568A1 (en) * | 2000-09-15 | 2003-04-24 | Gish Kurt C. | Methods of diagnosis of colorectal cancer, compositions and methods of screening for colorectal cancer modulators |
| AU2002252144A1 (en) * | 2001-02-27 | 2002-09-12 | Case Western Reserve University | Novel methods of diagnosis of metastatic colorectal cancer, compositions and methods of screening for modulators of metastatic colorectal cancer |
| US20040191782A1 (en) * | 2003-03-31 | 2004-09-30 | Yixin Wang | Colorectal cancer prognostics |
| US20070117164A1 (en) | 2003-04-08 | 2007-05-24 | Raskov Hans H | Method for detection of colorectal cancer in human samples |
| KR20060031809A (ko) * | 2003-06-09 | 2006-04-13 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 암 치료 및 진단용 조성물 및 방법 |
| US20050048494A1 (en) * | 2003-08-28 | 2005-03-03 | Yixin Wang | Colorectal cancer prognostics |
| CA2592504A1 (en) * | 2003-12-27 | 2005-07-14 | Aros Applied Biotechnology Aps | Classification of cancer |
-
2005
- 2005-12-23 NZ NZ544432A patent/NZ544432A/en unknown
-
2006
- 2006-12-22 ES ES06835771.4T patent/ES2525219T3/es active Active
- 2006-12-22 CA CA3015335A patent/CA3015335A1/en not_active Abandoned
- 2006-12-22 AU AU2006328023A patent/AU2006328023B2/en not_active Ceased
- 2006-12-22 KR KR1020137023872A patent/KR101530689B1/ko not_active Expired - Fee Related
- 2006-12-22 NZ NZ597363A patent/NZ597363A/xx unknown
- 2006-12-22 KR KR1020147036584A patent/KR101579934B1/ko not_active Expired - Fee Related
- 2006-12-22 ES ES11172410.0T patent/ES2484702T3/es active Active
- 2006-12-22 ES ES11172587.5T patent/ES2536233T3/es active Active
- 2006-12-22 EP EP11172410.0A patent/EP2371972B1/en not_active Not-in-force
- 2006-12-22 KR KR1020087018020A patent/KR101562644B1/ko not_active Expired - Fee Related
- 2006-12-22 WO PCT/NZ2006/000343 patent/WO2007073220A1/en not_active Ceased
- 2006-12-22 EP EP11172587.5A patent/EP2392678B1/en not_active Not-in-force
- 2006-12-22 NZ NZ586616A patent/NZ586616A/en unknown
- 2006-12-22 JP JP2008547140A patent/JP5632581B2/ja not_active Expired - Fee Related
- 2006-12-22 CN CN2006800529023A patent/CN101389957B/zh not_active Expired - Fee Related
- 2006-12-22 CA CA2640352A patent/CA2640352C/en not_active Expired - Fee Related
- 2006-12-22 EP EP06835771.4A patent/EP1977237B1/en not_active Not-in-force
-
2008
- 2008-06-20 US US12/214,782 patent/US10422005B2/en not_active Expired - Fee Related
-
2014
- 2014-05-19 JP JP2014103714A patent/JP6218141B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-21 US US14/860,024 patent/US20160068916A1/en not_active Abandoned
- 2015-12-28 JP JP2015257292A patent/JP6058780B2/ja not_active Expired - Fee Related
-
2019
- 2019-08-27 US US16/552,737 patent/US11180815B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11180815B2 (en) | Methods for treating colorectal cancer using prognostic genetic markers | |
| AU2008253836B2 (en) | Prognosis prediction for melanoma cancer | |
| AU2018200973B2 (en) | Prognosis prediction for colorectal cancer | |
| NZ555353A (en) | TNF antagonists | |
| AU2013263832B2 (en) | Prognosis prediction for colorectal cancer | |
| HK1127125B (en) | Prognosis prediction for colorectal cancer | |
| HK1127125A (en) | Prognosis prediction for colorectal cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20180824 |
|
| FZDE | Discontinued |
Effective date: 20211110 |