JP5586161B2 - Liquid oral composition - Google Patents

Description

  The present invention relates to a liquid oral composition having good appearance properties with suppressed turbidity, while containing an extract of the genus Oleaceae.

  It is known that oral symptoms and diseases such as caries (decayed teeth), bad breath, periodontal disease, gingivitis, and alveolar pyorrhea are caused by dental plaque. For example, the caries generation mechanism is considered as follows. In other words, bacteria such as lactic acid bacteria and mutans streptococci adhere to the pecyl layer on the surface of the teeth and adhere to food-derived sucrose by the action of glucosyltransferase (hereinafter referred to as “GTase”) secreted by the bacteria. Dental plaque is formed by denaturing the polysaccharide and firmly adhering to the tooth surface while growing. The bacteria contained in the plaque metabolize the saccharide, and the acid produced as a metabolite decalcifies the tooth enamel surface, thereby causing caries.

  Today, it is considered effective to inhibit the formation of plaque by inhibiting the action of GTase as one measure for preventing oral symptoms and diseases caused by dental plaque. Therefore, in recent years, substances having a GTase inhibitory action have been vigorously developed, and various plant extracts having a GTase inhibitory action have been reported (for example, see Patent Documents 1 and 2). On the other hand, many plant extracts that have been reported to have a GTase inhibitory action cannot be put to practical use because the GTase inhibitory action is not sufficient. However, it is known that the extract of the genus Ranaaceae is superior in GTase inhibitory action and can effectively exhibit plaque formation inhibitory effect in the oral cavity. (See Patent Document 2).

  Thus, the current situation is that the problems and the stability of the preparation when the extract of the plant of the genus Rubiaceae is used as a composition for oral cavity are not sufficiently studied.

Japanese Patent Laid-Open No. 4-95020 JP 2006-306844 A

  The inventors of the present invention have examined oral compositions containing an extract of the genus Rubiaceae, which is turbid when the extract of the genus Rabbitaceae is added to an aqueous solution. It has been newly found that a liquid oral composition containing the above has a problem in terms of appearance properties. Furthermore, the present inventors have newly found that the above-mentioned turbidity becomes remarkable in a liquid oral composition containing an extract of the plant of the genus Rabbitaceae in the high temperature condition. Therefore, there is an urgent need to solve the above-mentioned problems in actually commercializing and supplying a liquid oral composition containing an extract of the plant of the genus Rubiaceae.

  That is, an object of the present invention is to provide a liquid oral composition that has good appearance properties while preventing turbidity while containing an extract of the plant of the genus Rabbitaceae.

  As a result of diligent studies to solve the above-mentioned problems, the present inventors surprisingly formulated a combination of a specific nonionic surfactant and an alcohol-based solvent together with an extract of the genus Acrobaceae evening primrose. And when the compounding ratio of these compounding components satisfied a predetermined range, it has been found that a liquid oral composition having good appearance properties can be obtained while suppressing turbidity while containing the extract. The present invention has been completed by further studies based on this finding.

That is, this invention provides the composition for liquid oral cavity of the following aspect:
Item 1. (A) An extract of the genus Oenaceae, (B) Polyoxyethylene hydrogenated castor oil, polyoxyethylene (20) polyoxypropylene (4) cetyl ether, polyoxyethylene (20) polyoxypropylene (6) decyl Tetradecyl ether, and at least one nonionic surfactant selected from the group consisting of polyoxyethylene (30) polyoxypropylene (6) decyl tetradecyl ether, and (C) an alcohol solvent,
The component (B) is 4 parts by weight or more and the component (C) is 8 parts by weight or more per 1 part by weight of the component (A).
Furthermore, the liquid oral cavity composition characterized by the total amount of said (B) component and (C) component being 45 weight part or more per 1 weight part of said (A) component.
Item 2. The liquid oral cavity composition of Claim 1 or 2 whose compounding ratio of the said (A) component is 0.01 to 2 weight%.
Item 3. Item 3. The liquid oral composition according to Item 1 or 2, wherein the component (C) is at least one selected from the group consisting of glycerin, propylene glycol, and ethanol.
Item 4. Item 4. The composition for liquid oral cavity according to any one of Items 1 to 3, wherein the component (A) is an extract of seeds of the plant of the genus Ranunculaceae.
Item 5. Item 5. The liquid oral composition according to any one of Items 1 to 4, which is a mouthwash or a liquid dentifrice.

  According to the composition for liquid oral cavity of the present invention, the turbidity is suppressed while containing an extract of the plant of the genus Rubiaceae, which can exhibit good appearance properties. Furthermore, since the liquid oral composition of the present invention can suppress the occurrence of turbidity even at high temperatures, it is also excellent in terms of high-temperature stability. As described above, the liquid oral composition of the present invention has a good appearance property, and can effectively exert the plaque formation inhibitory effect based on the GTase inhibitory action of the extract. It is highly useful as a technique for commercializing liquid oral preparations using extracts.

It is a figure which shows the parameter | index of the criterion used when evaluating the external appearance property of the composition for oral cavity in Test example 1-4.

  The liquid oral composition of the present invention comprises (A) an extract of the plant of the genus Rhizoaceae, (B) a specific nonionic surfactant, and (C) an alcohol-based solvent at a blending ratio in a predetermined range. It is characterized by this. Hereinafter, the liquid oral cavity composition of the present invention will be described in detail.

(A) Extract of red clover family primrose genus plant The liquid oral composition of the present invention is an extract of a red clover family primrose genus plant as a GTase inhibitor (hereinafter sometimes simply referred to as component (A)). contains.

The plant of the genus Rabbitaceae is not particularly limited, and examples thereof include Oenothera biennis , Oenothera striata , Oenotheraerythrosepala , and Oenothera laciniata . Of these, the evening primrose is preferable.

  The extract of the genus Oenothera spp. Is not limited as long as it is extracted from the whole plant of the plant or a part of the plant such as seeds, roots, stems, leaves, and florets. Extracted from plant seeds.

  Moreover, a polar solvent is mentioned as a preferable extraction solvent used for the extraction of the extract of the Rabbitaceae evening primrose plant. Examples of such polar solvents include water; lower alcohols having 1 to 5 carbon atoms such as methanol, ethanol, propanol, isopropyl alcohol, and butanol; polyhydric alcohols such as 1,3-butylene glycol, glycerin, and polyethylene glycol. Acetone; ethyl ether; ethyl acetate; methyl acetate and the like. These extraction solvents may be used alone or in combination of two or more. The extraction solvent is preferably water, a lower alcohol having 1 to 5 carbon atoms, and a mixed liquid of water having a lower alcohol having 1 to 5 carbon atoms and water; more preferably water, ethanol, and a mixed liquid of ethanol and water; Is a mixture of ethanol and water. When a mixed solution of lower alcohol having 1 to 5 carbon atoms and water is used as the extraction solvent, the content ratio of the lower alcohol to the total weight of the mixed solution is, for example, 0.0001 to 99.9% by weight, preferably Is a ratio of 40 to 99.9% by weight, more preferably 50 to 90% by weight.

  The extract of the genus Rhizophoraceae is obtained by extracting the plant part to be extracted as it is or after drying, shredded, crushed, pressed, boiled or fermented with the above extraction solvent. It is done. As the extraction method, a commonly used extraction method for plant extracts can be employed, and specifically, immersion methods such as cold immersion and digestion; a method of stirring under heating; or a percolation method, etc. Is exemplified.

  In addition, prior to extraction of the plant of the genus Ranunculaceae with an extraction solvent, as a pretreatment, a depolarization treatment is performed in advance by using a nonpolar organic solvent such as a pressing method or hexane, and an extra portion is removed from the plant during the extraction treatment. It is desirable to prevent the extraction of fresh lipids.

  The extract of the plant of the genus Rubiaceae obtained by the above extraction method is in a liquid state, and in the present invention, the extract may be used in a liquid state, and if necessary, subjected to treatment such as concentration and drying. It may be used as a concentrate or a dry product. Further, after concentration or drying, the concentrated or dried product may be used after being purified by washing with an insoluble solvent, or may be used by further dissolving or suspending it in an appropriate solvent. It is also possible to obtain and purify a fraction having GTase inhibitory activity using the obtained extract using a conventional purification method such as a countercurrent distribution method or liquid chromatography. .

  In addition, for convenience, a commercially available extract may be used as an extract of the plant belonging to the genus Pinaceae. Specific examples of commercially available extracts of the genus Rhizopus genus are evening primrose extract-P (manufactured by Oriza Yuka Co., Ltd.), evening primrose extract-PC (manufactured by Oriza Yuka Co., Ltd.), and evening primrose extract. -WSPS (manufactured by Oriza Oil & Chemical Co., Ltd.), evening primrose extract-PH (manufactured by Oriza Oil & Chemical Co., Ltd.), evening primrose extract-WSPH (manufactured by Oriza Oil & Chemical Co., Ltd.), evening primrose extract-LC (manufactured by Oriza Oil & Chemical Co., Ltd.), Examples include Luna White B (Ichimaru Falcos Co., Ltd.). All of the extracts of the genus Ranunculaceae exemplified here are extracts produced from the seeds of evening primrose.

(B) Nonionic surfactant In the liquid oral composition of the present invention, as the nonionic surfactant, polyoxyethylene hydrogenated castor oil, polyoxyethylene (20) polyoxypropylene (4) cetyl ether, polyoxyethylene At least one selected from the group consisting of oxyethylene (20) polyoxypropylene (6) decyl tetradecyl ether and polyoxyethylene (30) polyoxypropylene (6) decyl tetradecyl ether (hereinafter simply referred to as (B) It may be described as an ingredient).

  For the polyoxyethylene hydrogenated castor oil used as the component (B), the average number of moles of ethylene oxide added is not particularly limited. For example, polyoxyethylene (5) hydrogenated castor oil, polyoxyethylene ( 10) hydrogenated castor oil, polyoxyethylene (20) hydrogenated castor oil, polyoxyethylene (30) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (50) hydrogenated castor oil, polyoxyethylene ( 60) hydrogenated castor oil, polyoxyethylene (80) hydrogenated castor oil, polyoxyethylene (100) hydrogenated castor oil, and the like can be used. Among these, from the viewpoint of more effectively preventing turbidity of the liquid oral composition, preferably polyoxyethylene (20) hardened castor oil, polyoxyethylene (30) hardened castor oil, polyoxyethylene (40) hardened Castor oil, polyoxyethylene (50) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil, polyoxyethylene (80) hydrogenated castor oil, polyoxyethylene (100) hydrogenated castor oil, and more preferably Examples include oxyethylene (40) hydrogenated castor oil, polyoxyethylene (50) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil, polyoxyethylene (80) hydrogenated castor oil, and polyoxyethylene (100) hydrogenated castor oil. Particularly preferred are polyoxyethylene (60) hydrogenated castor oil and polyoxyethylene (100) hydrogenated castor oil. These polyoxyethylene hydrogenated castor oils may be used individually by 1 type, and may be used in combination of 2 or more type.

  Further, in the composition for liquid oral cavity of the present invention, as component (B), polyoxyethylene hydrogenated castor oil, polyoxyethylene (20) polyoxypropylene (4) cetyl ether, and polyoxyethylene (20) polyoxypropylene (6) Decyl tetradecyl ether and polyoxyethylene (30) polyoxypropylene (6) Decyl tetradecyl ether may be used alone or in combination of two or more thereof. May be used.

  From the viewpoint of more effectively suppressing the turbidity of the liquid oral composition, the component (B) preferably includes polyoxyethylene hydrogenated castor oil, and more preferably includes polyoxyethylene (60) hydrogenated castor oil. .

  In addition, when two or more kinds of nonionic surfactants are used as the component (B), the combination mode is not particularly limited. However, as an example of a suitable combination, two or more kinds of polyoxyethylene cured castors are used. Oil combination, particularly preferably polyoxyethylene (60) hydrogenated castor oil (hereinafter sometimes referred to as (Ba) component) and polyoxyethylene (100) hydrogenated castor oil (hereinafter referred to as (Bb) component) And a combination thereof may be exemplified. When the (Ba) component and the (Bb) component are used in combination as the (B) component, the mixing ratio is not particularly limited, but as an example, there is 1 (Bb) component per 100 parts by weight of the (Ba) component. An example is 10000 parts by weight, preferably 10 to 1000 parts by weight.

  Furthermore, as an example of other suitable combinations when two or more kinds of nonionic surfactants are used as the component (B), polyoxyethylene hydrogenated castor oil (hereinafter referred to as the component (B1) may be used. And polyoxyethylene (20) polyoxypropylene (4) cetyl ether, polyoxyethylene (20) polyoxypropylene (6) decyl tetradecyl ether, and polyoxyethylene (30) polyoxypropylene (6) decyl A combination with at least one of tetradecyl ethers (hereinafter sometimes referred to as component (B2)) is exemplified. When (B) component is used in combination with (B1) component and (B2) component, the mixing ratio is not particularly limited. As an example, per 100 parts by weight of (B1) component, (B2) component is the total amount. 1 to 10000 parts by weight, preferably 10 to 1000 parts by weight.

(C) Alcohol-based solvent The liquid oral composition of the present invention contains an alcohol-based solvent (hereinafter sometimes simply referred to as the component (C)). The alcohol solvent used in the present invention is not particularly limited as long as it is pharmaceutically acceptable, and water-soluble alcohol solvents such as lower alcohols and polyhydric alcohols can be used. Specific examples of alcohol solvents include lower alcohols having 2 to 5 carbon atoms such as ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, tert-butanol, n-pentanol; glycerin, propylene glycol, butylene Examples thereof include polyhydric alcohols such as glycol, hexylene glycol and diethylene glycol. Among these, from the viewpoint of more effectively suppressing the turbidity of the liquid oral composition, ethanol, glycerin, propylene glycol, butylene glycol, and diethylene glycol are preferable, and ethanol, glycerin, and propylene glycol are more preferable. It is done.

  These alcohol solvents may be used alone or in combination of two or more.

In particular, in the present invention, when two or more alcohol solvents are used in combination as the component (C), the turbidity suppressing effect of the liquid oral composition may be enhanced. The combination of alcohol solvents that can enhance the turbidity-suppressing effect of the liquid oral composition is a combination of a lower alcohol and a polyhydric alcohol; preferably a combination of ethanol and glycerin; more preferably ethanol, glycerin, and propylene glycol The combination of is illustrated. Thus, when combining 2 or more types of alcohol solvents, the mixing ratio is not particularly limited, but the following ranges are exemplified as an example.
Combination of lower alcohol and polyhydric alcohol:
1 to 10000 parts by weight of polyhydric alcohol per 100 parts by weight of lower alcohol, preferably 10 to 1000 parts by weight Combination of ethanol and glycerin:
1 to 10000 parts by weight, preferably 10 to 1000 parts by weight of glycerin per 100 parts by weight of ethanol. Combination of ethanol, glycerin and propylene glycol:
1 to 10,000 parts by weight of glycerin and 1 to 10,000 parts by weight of propylene glycol per 100 parts by weight of ethanol; preferably 10 to 1000 parts by weight of glycerin and 10 to 1000 parts by weight of propylene glycol.

(A)-(C) component blending ratio and each blending proportion The liquid oral composition of the present invention comprises (B) component at least 4 parts by weight and (C) component per 1 part by weight of component (A). The ratio is 8 parts by weight or more. From the viewpoint of suppressing turbidity and further maintaining turbidity under high temperature conditions to maintain a stable solubilized state, 4 parts by weight or more of (B) component per 1 part by weight of (A) component and ( C) component is 8 parts by weight or more, preferably (B) component is 4 to 8992 parts by weight and (C) component is 8 to 8996 parts by weight, more preferably (B) component is 4 to 1992 parts by weight and (C) A ratio in which the component is 8 to 1996 parts by weight is mentioned.

  The composition for liquid oral cavity of the present invention satisfies the ratio that the total amount of the component (B) and the component (C) is 45 parts by weight or more per 1 part by weight of the component (A). In particular, from the viewpoint of maintaining the state in which turbidity is suppressed even under high temperature conditions and providing high-temperature stability of appearance properties, (B) component and (C) component per 1 part by weight of component (A). The total amount is 50 to 9000 parts by weight, more preferably 54 to 2000 parts by weight.

  By including the components (A) to (C) in the ratios described above, it becomes possible to obtain a liquid oral composition in which turbidity is suppressed while containing the component (A) that tends to induce turbidity. . In addition, the weight of the component (A) shown here is a value converted to the dry weight of the extract of the plant of the genus Aceraceae.

  In the composition for liquid oral cavity of the present invention, the blending ratio of the component (A) may be within a range that effectively exhibits the plaque formation inhibitory effect based on the GTase inhibitory action of the component (A). Component (A) is contained in an amount of 0.001% by weight or more, preferably 0.01-2% by weight, more preferably 0.05-2% by weight, based on the total amount of the oral composition. desirable. In general, the higher the blending ratio of the component (A) in the aqueous solution, the more the turbidity at the time of preparation becomes more pronounced, and the occurrence of turbidity under high temperature conditions tends to become obvious, but the liquid oral composition of the present invention According to the product, the component (A) has a high blending ratio of 0.1 to 2% by weight (preferably 0.1 to 1.5% by weight, more preferably 0.5 to 1.5% by weight). However, there is an advantage that the white turbidity at the time of preparation can be remarkably suppressed, and further, the occurrence of white turbidity under high temperature conditions can be effectively suppressed. The unit “% by weight” of the blending ratio of the component (A) shown here is a value converted to the dry weight of the extract of the genus Acanthaceae.

  Further, the blending ratio of the component (B) in the composition for liquid oral cavity of the present invention is appropriately set within the range satisfying the ratio of the components (A) to (C) described above, but as an example, the liquid oral cavity The total amount of component (B) is 0.004% by weight or more, preferably 0.04 to 90% by weight, and more preferably 0.2 to 89% by weight.

  Further, the blending ratio of the component (C) in the liquid oral cavity composition of the present invention is appropriately set within the range satisfying the ratio of the components (A) to (C) described above. As an example, the liquid oral cavity The total amount of component (C) is 0.008% by weight or more, preferably 0.08 to 90% by weight, and more preferably 0.4 to 89% by weight.

Other Compounding Components The liquid oral composition of the present invention contains water as a carrier in addition to the components (A) to (C). In other words, in the composition for liquid oral cavity of the present invention, the balance other than the components (A) to (C) and the components added as necessary is water. The water used in the liquid oral cavity composition of the present invention may be any of purified water, ion exchange water, ultrapure water, tap water and the like. Specifically, the mixing ratio of water is 10 to 99% by weight, preferably 20 to 99% by weight, more preferably 30 to 95% by weight, based on the total amount of the liquid oral composition.

Further, in the liquid oral composition of the present invention, in addition to the components (A) to (C), an antibacterial agent for oral bacteria and other GTase, if necessary, within a range not impairing the effects of the present invention. Inhibitors may be combined and blended. By using such an antibacterial agent and a GTase inhibitor in combination, the anti-cariogenic effect and the plaque formation inhibitory effect based on the component (A) can be additively or synergistically enhanced. Examples of such antibacterial agents include chlorhexidine hydrochloride, cetylpyridinium chloride, sorbic acid, hinokitiol, isopropylmethylphenol, decalinium chloride, triclosan, chlorhexidine hydrochloride, potassium iodide and the like. Other GTase inhibitors include, for example, Vitis plant extracts, dextranase, mutanase, sodium monofluorophosphate, sodium fluoride, stannous fluoride, tastein, tannins , Ellagic acid, polyphenol, oolong tea extract, green tea extract, assembly, Taiso, fennel, glaze, gentian, senso, rye gall, yellow ream and the like.

  Furthermore, in addition to the above components, the liquid oral composition of the present invention can also be blended with components that are usually used in oral compositions as needed, as long as the effects of the present invention are not impaired. . Examples of such components include abrasives, binders, thickeners, foaming agents, fragrances, flavoring agents, sweeteners, preservatives, anti-inflammatory agents, disinfectants, other antibacterial agents, pigments, and thickeners. , Buffers, other surfactants, pH adjusters, antioxidants, and the like.

Method for Producing Liquid Oral Composition The liquid oral composition of the present invention is produced by mixing predetermined amounts of the components (A) to (C) and, if necessary, predetermined amounts of other components with water. be able to. In the production of the liquid oral composition of the present invention, the mixing order of each formulation component is not particularly limited, in order to more effectively suppress turbidity during the preparation of the liquid oral composition, Component (A) is mixed with part or all of component (C), and the resulting mixture of component (A) and component (C) is mixed with component (B), water, and if necessary, component (C). It is desirable to prepare by mixing the remainder.

Application and form of liquid oral composition The liquid oral composition of the present invention can effectively exert the plaque formation inhibitory effect based on the GTase inhibitory action of the component (A) when applied to the oral cavity. Therefore, it can be used for the purpose of preventing oral diseases and symptoms such as caries, bad breath, periodontal disease, and alveolar pyorrhea. In particular, the composition for oral cavity of the present invention has an excellent anti-cariogenic effect and is suitable for use for the purpose of preventing caries.

Further, since the liquid oral composition of the present invention is liquid, the liquid oral preparation in the form of a mouthwash (mouth wash), liquid dentifrice, mouth rinse, gargle, mouth freshener (mouse spray, etc.) and the like. Offered as.
Among these, a mouthwash and a liquid dentifrice are mentioned as a suitable example.

  Hereinafter, the present invention will be described in detail based on examples, but the present invention is not limited thereto. In the examples, “POE” is an abbreviation for polyoxyethylene, and “POP” is an abbreviation for polyoxypropylene.

Test example 1
Oral compositions (Example 1-11 and Comparative Example 1-7) described in Tables 1 and 2 were prepared. That is, after mixing (A) component and (C) component, the composition for oral cavity was prepared by adding and mixing (B) component and water.

The appearance properties immediately after preparation of each oral composition were evaluated according to the following criteria. Furthermore, each composition for oral cavity was preserve | saved for 30 days under light-shielding conditions at 50 degreeC, and the external appearance property after a preservation | save was also evaluated according to the following criteria. Furthermore, based on the evaluation results of appearance properties immediately after preparation and after storage at 50 ° C. for 30 days, comprehensive evaluation was performed according to the following criteria.
<Criteria for appearance properties>
○: Turbidity is not recognized with the naked eye.
Δ: Slight turbidity is observed with the naked eye.
X: Obvious turbidity is recognized with the naked eye.
For reference, FIG. 1 shows an index of the above determination criterion.
<Criteria for comprehensive evaluation>
A: No turbidity is observed at all immediately after preparation and after storage at 50 ° C. for 30 days.
○: No turbidity was observed immediately after preparation, and slight turbidity was observed after storage at 50 ° C. for 30 days.
Δ: Turbidity is not observed immediately after preparation, but turbidity is observed after storage at 50 ° C. for 30 days.
X: Turbidity is observed both immediately after preparation and after storage at 50 ° C. for 30 days.

  The results are shown in Tables 1 and 2. From this result, when the total amount of polyoxyethylene (60) hydrogenated castor oil and alcohol solvent is contained in a ratio of 45 parts by weight or more per 1 part by weight of the extract of evening primrose, The composition did not become cloudy and had good appearance properties (see Example 1-11). In addition, when the total amount of polyoxyethylene (60) hydrogenated castor oil and alcoholic solvent is 50 parts by weight or more per 1 part by weight of evening primrose extract, not only immediately after preparation, but also severe test Even after (30 days at 50 ° C.), good appearance properties could be maintained without causing turbidity. On the other hand, when the total amount of polyoxyethylene (60) hydrogenated castor oil and alcoholic solvent is less than 45 parts by weight per 1 part by weight of evening primrose extract, turbidity is observed immediately after preparation, and a severe test (50 After 30 days), turbidity became prominent (see Comparative Example 1-7).

Test example 2
Oral compositions (Examples 12-19 and Comparative Examples 8-25) described in Table 3-5 were prepared. That is, after mixing (A) component and (C) component, the composition for oral cavity was prepared by adding and mixing (B) component or another surfactant, and water.

  Immediately after the preparation of each oral composition and after 30 days storage at 50 ° C., the appearance properties were evaluated in the same manner as in Test Example 1 above.

  The results are shown in Table 3-5. From this result, as a surfactant, polyoxyethylene (60) hydrogenated castor oil, polyoxyethylene (100) hydrogenated castor oil, polyoxyethylene (20) polyoxypropylene (4) cetyl ether, polyoxyethylene (20) Polyoxypropylene (6) decyl tetradecyl ether and polyoxyethylene (30) polyoxypropylene (6) decyl tetradecyl ether were selected, and the total amount of these surfactants and alcoholic solvent was extracted from evening primrose It was confirmed that turbidity during preparation can be suppressed by setting the conditions to 45 parts by weight or more per part by weight (see Examples 12-19). On the other hand, when other surfactant was used, even if the said conditions were satisfied, it turned out that the turbidity at the time of preparation cannot be suppressed (refer comparative example 8-25).

Test example 3
Oral compositions described in Table 6 (Examples 20-27 and Comparative Examples 26-29) were prepared. That is, after mixing (A) component and (C) component, (B) component and water were added and mixed, and the composition for oral cavity was prepared.

  Immediately after the preparation of each oral composition and after 30 days storage at 50 ° C., the appearance properties were evaluated in the same manner as in Test Example 1 above.

  The results are shown in Table 6. This result also showed the same tendency as Test Example 1-2. In addition, it is possible to use a ratio of 4 parts by weight or more of polyoxyethylene (60) hydrogenated castor oil and 8 parts by weight or more of alcoholic solvent per 1 part by weight of the extract of evening primrose as a surfactant. It was also confirmed that it is effective in suppressing the occurrence of turbidity during storage at high temperatures.

Test example 4
The composition for oral cavity described in Table 7 (Examples 28-31) was prepared. That is, after mixing (A) component and (C) component, (B) component and water were added and mixed, and the composition for oral cavity was prepared.

  Immediately after the preparation of each oral composition and after 30 days storage at 50 ° C., the appearance properties were evaluated in the same manner as in Test Example 1 above.

  The results are shown in Table 7. This result also showed the same tendency as Test Example 1-2. In particular, from this result, even when the evening primrose extract has a high blending ratio of 1% by weight or 1.5% by weight, by blending a specific nonionic surfactant and an alcohol-based agent at a specific ratio It was revealed that turbidity during preparation can be suppressed and the occurrence of turbidity during storage at high temperatures can be reduced.

Test Example 5
Oral compositions described in Table 8 (Comparative Examples 30-41) were prepared in the same manner as in Test Example 1. Further, the appearance properties of each oral composition immediately after preparation and after storage at 50 ° C. for 30 days were evaluated by the same method as in Test Example 1.

  The results are shown in Table 8. From these results, it was confirmed that turbidity was observed both immediately after preparation and after storage at 50 ° C. for 30 days when either (B) component or (C) component was not blended.

Test Example 6
As evening primrose extract, evening primrose extract-WSPS (manufactured by Oriza Oil Chemical Co., Ltd.), evening primrose extract-PH (manufactured by Oriza Oil Chemical Co., Ltd.), evening primrose extract-WSPH (manufactured by Oriza Oil Chemical Co., Ltd.), evening primrose extract-LC (Oriza oil) When the same test as in Test Example 1-5 was performed using Yuka Kagaku Co., Ltd.) and Luna White B (manufactured by Ichimaru Falcos Co., Ltd.), the same tendency as in Test Example 1-5 was obtained. Obtained.

Claims (6)

(A) An extract of the genus Oenaceae, (B) Polyoxyethylene hydrogenated castor oil, polyoxyethylene (20) polyoxypropylene (4) cetyl ether, polyoxyethylene (20) polyoxypropylene (6) decyl Liquid oral cavity containing tetradecyl ether and at least one nonionic surfactant selected from the group consisting of polyoxyethylene (30) polyoxypropylene (6) decyl tetradecyl ether, and (C) an alcohol-based solvent A composition for
The blending ratio of the component (A) is 0.001 to 1.5% by weight,
The blending ratio of the component (B) is 2 to 90% by weight,
The blending ratio of the component (C) is 0.008 to 90% by weight,
The component (B) is 4 parts by weight or more and the component (C) is 8 parts by weight or more per 1 part by weight of the component (A).
Furthermore, the component (A) 1 part by weight per the total amount of component (B) and (C) component Ri der than 50 parts by weight,
Component (C) is at least one water-soluble alcohol solvent der wherein Rukoto selected from the group consisting of lower alcohols and polyhydric alcohols, liquid oral composition. The composition for liquid oral cavity according to claim 1, wherein the blending ratio of the component (A) is 0.5 to 1.5% by weight. The liquid oral cavity composition of Claim 1 or 2 whose said (B) component is 14 weight part or more per 1 weight part of said (A) component. The liquid oral cavity composition according to any one of claims 1 to 3, wherein the component (C) is at least one selected from the group consisting of glycerin, propylene glycol, and ethanol. The composition for liquid oral cavity according to any one of claims 1 to 4, wherein the component (A) is an extract of seeds of the plant of the genus Rubiaceae. The composition for liquid oral cavity according to any one of claims 1 to 5, which is a mouthwash or a liquid dentifrice.

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